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Aliases for HTR7 Gene

Aliases for HTR7 Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled) 2 3
  • 5-HT-7 3 4
  • 5-HT-X 3 4
  • 5-HT7 3 4
  • 5-Hydroxytryptamine Receptor 7 3
  • Serotonin Receptor 7 4

External Ids for HTR7 Gene

Summaries for HTR7 Gene

Entrez Gene Summary for HTR7 Gene

  • The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR7 Gene

HTR7 (5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled) is a Protein Coding gene. Diseases associated with HTR7 include autistic disorder. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR7 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Tocris Summary for HTR7 Gene

  • Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, learning and memory and smooth muscle relaxation. The human 5-HT7 receptor gene has been localized to chromosome 10 (10q21-24).

Gene Wiki entry for HTR7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR7 Gene

Genomics for HTR7 Gene

Genomic Location for HTR7 Gene

Start:
90,740,818 bp from pter
End:
90,857,914 bp from pter
Size:
117,097 bases
Orientation:
Minus strand

Genomic View for HTR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR7 Gene

Regulatory Elements for HTR7 Gene

Proteins for HTR7 Gene

  • Protein details for HTR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34969-5HT7R_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 7
    Protein Accession:
    P34969
    Secondary Accessions:
    • B5BUP6
    • P78336
    • P78372
    • P78516
    • Q5VX01
    • Q5VX02
    • Q5VX03

    Protein attributes for HTR7 Gene

    Size:
    479 amino acids
    Molecular mass:
    53555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HTR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR7 Gene

Proteomics data for HTR7 Gene at MOPED

Post-translational modifications for HTR7 Gene

Other Protein References for HTR7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR7 Gene

Domains for HTR7 Gene

Gene Families for HTR7 Gene

HGNC:
  • HTR :5-HT (serotonin) receptors
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
IUPHAR :

UniProtKB/Swiss-Prot:

5HT7R_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P34969
genes like me logo Genes that share domains with HTR7: view

Function for HTR7 Gene

Molecular function for HTR7 Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate cyclase,unlikely to be associated with autistic disorder
UniProtKB/Swiss-Prot Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Gene Ontology (GO) - Molecular Function for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IEA --
genes like me logo Genes that share ontologies with HTR7: view
genes like me logo Genes that share phenotypes with HTR7: view

Animal Models for HTR7 Gene

MGI Knock Outs for HTR7:

miRNA for HTR7 Gene

miRTarBase miRNAs that target HTR7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR7 Gene

Localization for HTR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR7 Gene COMPARTMENTS Subcellular localization image for HTR7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8226867
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR7: view

Pathways for HTR7 Gene

genes like me logo Genes that share pathways with HTR7: view

Gene Ontology (GO) - Biological Process for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8226867
GO:0007210 serotonin receptor signaling pathway TAS 8226867
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR7: view

Compounds for HTR7 Gene

(5) Tocris Compounds for HTR7 Gene

Compound Action Cas Number
8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 [76135-31-4]
AS 19 Reported potent 5-HT7 agonist [1000578-26-6]
LP 44 High affinity 5-HT7 agonist [824958-12-5]
SB 258719 hydrochloride Selective 5-HT7 antagonist [195199-95-2]
SB 269970 hydrochloride Potent selective 5-HT7 antagonist. Brain penetrant [201038-74-6]

(1) HMDB Compounds for HTR7 Gene

Compound Synonyms Cas Number PubMed IDs
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9

(14) Drugbank Compounds for HTR7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Amisulpride
53583-79-2 target antagonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Asenapine
65576-45-6 target antagonist
Bromocriptine
  • Bromergocryptine
25614-03-3 target antagonist
Cabergoline
  • Cabergolina [Spanish]
81409-90-7 target antagonist

(50) IUPHAR Ligand for HTR7 Gene

Ligand Type Action Affinity Pubmed IDs
SB 207710 Antagonist Antagonist 10.3
cyproheptadine Antagonist Antagonist 10.2
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
[3H]5-HT Agonist Full agonist 9
(+)-LSD Agonist Full agonist 9
[3H]SB269970 Antagonist Antagonist 8.92
SB269970 Antagonist Antagonist 8.9
SB656104 Antagonist Antagonist 8.7
[3H]LSD Agonist Full agonist 8.7
E55888 Agonist Full agonist 8.6
oleamide Allosteric regulator Negative 8.6
pirenperone Antagonist Antagonist 8.5
perphenazine Antagonist Antagonist 8.1
1-naphthylpiperazine Agonist Full agonist 8
risperidone Antagonist Antagonist 7.8
ziprasidone Antagonist Antagonist 7.8
EMDT Agonist Full agonist 7.8
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
MPDT Antagonist Antagonist 7.7
2-Br-LSD Antagonist Antagonist 7.5
SB 258719 Antagonist Inverse agonist 7.5
fluperlapine Antagonist Inverse agonist 7.5
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
yohimbine Antagonist Antagonist 7.3
iloperidone Antagonist Antagonist 7.2
tryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
5-MeOT Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
cyamemazine Antagonist Antagonist 6.3
ketanserin Inhibitor Inhibition 6.3
LY344864 Agonist Full agonist 6.3
5-CT Agonist Full agonist 6.1
haloperidol Antagonist Antagonist 6.1
xanomeline Agonist Full agonist 5.9
dipropyl-5-CT Agonist Full agonist 5.8
mesulergine Antagonist Antagonist 5.7
sumatriptan Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
[3H]5-CT Agonist Agonist
chlorpromazine Channel blocker None

(16) Novoseek inferred chemical compound relationships for HTR7 Gene

Compound -log(P) Hits PubMed IDs
way 100635 82.8 3
5-hydroxytryptamine 79.2 9
gr 127935 67.5 1
metergoline 64.7 1
sumatriptan 62.1 2

(4) PharmGKB related drug/compound annotations for HTR7 Gene

Drug/compound Annotation
atorvastatin CA
hmg coa reductase inhibitors CA
pravastatin CA
simvastatin CA
genes like me logo Genes that share compounds with HTR7: view

Transcripts for HTR7 Gene

mRNA/cDNA for HTR7 Gene

Unigene Clusters for HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: -

Relevant External Links for HTR7 Gene

GeneLoc Exon Structure for
HTR7
ECgene alternative splicing isoforms for
HTR7

Expression for HTR7 Gene

mRNA expression in normal human tissues for HTR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR7 Gene

This gene is overexpressed in Testis (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR7 Gene

SOURCE GeneReport for Unigene cluster for HTR7 Gene Hs.73739

mRNA Expression by UniProt/SwissProt for HTR7 Gene

P34969-5HT7R_HUMAN
Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
genes like me logo Genes that share expressions with HTR7: view

Orthologs for HTR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR7 36
  • 99.37 (n)
  • 99.79 (a)
HTR7 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR7 36
  • 91.49 (n)
  • 95.59 (a)
HTR7 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR7 36
  • 91.28 (n)
  • 96.06 (a)
HTR7 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr7 36
  • 90.88 (n)
  • 95.63 (a)
Htr7 16
Htr7 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTR7 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr7 36
  • 90.82 (n)
  • 96.76 (a)
chicken
(Gallus gallus)
Aves HTR7 36
  • 79.17 (n)
  • 84.56 (a)
HTR7 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR7 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia htr7-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia htr7 36
  • 70.18 (n)
  • 80.58 (a)
zebrafish
(Danio rerio)
Actinopterygii HTR7 (1 of 4) 37
  • 66 (a)
OneToMany
HTR7 (2 of 4) 37
  • 66 (a)
OneToMany
HTR7 (3 of 4) 37
  • 79 (a)
OneToMany
HTR7 (4 of 4) 37
  • 73 (a)
OneToMany
LOC562111 36
  • 73.04 (n)
  • 83.66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT7 36
  • 53.69 (n)
  • 43.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 36
  • 55.82 (n)
  • 46.69 (a)
5-HT7 37
  • 29 (a)
OneToOne
CG7431 38
  • 41 (a)
CG6919 38
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea ser-7 36
  • 49.3 (n)
  • 36.53 (a)
ser-7 37
  • 27 (a)
OneToOne
C09B7.1b 38
  • 32 (a)
C09B7.1a 38
  • 32 (a)
M03F4.3 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToOne
Species with no ortholog for HTR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR7 Gene

ENSEMBL:
Gene Tree for HTR7 (if available)
TreeFam:
Gene Tree for HTR7 (if available)

Paralogs for HTR7 Gene

Pseudogenes.org Pseudogenes for HTR7 Gene

genes like me logo Genes that share paralogs with HTR7: view

Variants for HTR7 Gene

Sequence variations from dbSNP and Humsavar for HTR7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs955064 -- 90,782,742(-) TGTAC(A/C)TGTCA intron-variant
rs1045949 -- 90,740,967(-) TTGCT(A/G)AAGTG utr-variant-3-prime
rs1342085 -- 90,819,499(-) GATGA(C/T)GTACT intron-variant
rs1418212 -- 90,771,843(+) GCAAA(C/G)GCACC intron-variant
rs1418213 -- 90,741,893(+) CATAG(A/G)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR7 Gene

Variant ID Type Subtype PubMed ID
esv2422237 CNV Duplication 17116639
nsv467432 CNV Gain 19166990
nsv516743 CNV Gain 19592680
nsv831945 CNV Gain 17160897
esv1923742 CNV Deletion 18987734
esv2739474 CNV Deletion 23290073
esv26200 CNV Loss 19812545

Relevant External Links for HTR7 Gene

HapMap Linkage Disequilibrium report
HTR7
Human Gene Mutation Database (HGMD)
HTR7

Disorders for HTR7 Gene

(1) MalaCards Diseases for HTR7 Gene

Search for HTR7 Gene in MalaCards »

(2) Novoseek inferred disease relationships for HTR7 Gene

Disease -log(P) Hits PubMed IDs
migraine 32.2 1
schizophrenia 19.9 1

Relevant External Links for HTR7

Genetic Association Database (GAD)
HTR7
Human Genome Epidemiology (HuGE) Navigator
HTR7
genes like me logo Genes that share disorders with HTR7: view

No data available for UniProtKB/Swiss-Prot for HTR7 Gene

Publications for HTR7 Gene

  1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PMID: 8226867) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1993) 2 3 4 23
  2. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M. … Kennedy J.L. (Schizophr. Res. 2001) 3 23 49
  3. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. (PMID: 9084407) Heidmann D.E.A. … Hamblin M.W. (J. Neurochem. 1997) 3 4 23
  4. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. (PMID: 17406648) Cross S. … Veenstra-Vanderweele J. (Neuropsychopharmacology 2008) 3 23 49
  5. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. (PMID: 16192982) Ikeda M. … Ozaki N. (Neuropsychopharmacology 2006) 3 23 49

Products for HTR7 Gene

Sources for HTR7 Gene

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