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Aliases for HTR7 Gene

Aliases for HTR7 Gene

  • 5-Hydroxytryptamine Receptor 7 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled) 2 3
  • 5-HT-7 3 4
  • 5-HT-X 3 4
  • 5-HT7 3 4
  • Serotonin Receptor 7 4

External Ids for HTR7 Gene

Previous GeneCards Identifiers for HTR7 Gene

  • GC10M091383
  • GC10M091723
  • GC10M092631
  • GC10M092165
  • GC10M092490
  • GC10M086129

Summaries for HTR7 Gene

Entrez Gene Summary for HTR7 Gene

  • The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR7 Gene

HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include autistic disorder and periodic fever, menstrual cycle dependent. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR7 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Tocris Summary for HTR7 Gene

  • Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation.

Gene Wiki entry for HTR7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR7 Gene

Genomics for HTR7 Gene

Regulatory Elements for HTR7 Gene

Promoters for HTR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HTR7 on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR7 Gene

Chromosome:
10
Start:
90,740,818 bp from pter
End:
90,857,914 bp from pter
Size:
117,097 bases
Orientation:
Minus strand

Genomic View for HTR7 Gene

Genes around HTR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR7 Gene

Proteins for HTR7 Gene

  • Protein details for HTR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34969-5HT7R_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 7
    Protein Accession:
    P34969
    Secondary Accessions:
    • B5BUP6
    • P78336
    • P78372
    • P78516
    • Q5VX01
    • Q5VX02
    • Q5VX03

    Protein attributes for HTR7 Gene

    Size:
    479 amino acids
    Molecular mass:
    53555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HTR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR7 Gene

Proteomics data for HTR7 Gene at MOPED

Post-translational modifications for HTR7 Gene

  • Glycosylation at Asn 5 and Asn 66
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR7 Gene

Antibody Products

No data available for DME Specific Peptides for HTR7 Gene

Domains & Families for HTR7 Gene

Graphical View of Domain Structure for InterPro Entry

P34969

UniProtKB/Swiss-Prot:

5HT7R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR7: view

Function for HTR7 Gene

Molecular function for HTR7 Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate cyclase,unlikely to be associated with autistic disorder
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
genes like me logo Genes that share phenotypes with HTR7: view

Animal Models for HTR7 Gene

MGI Knock Outs for HTR7:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR7 Gene

Localization for HTR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR7 Gene COMPARTMENTS Subcellular localization image for HTR7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HTR7 Gene

Pathways & Interactions for HTR7 Gene

genes like me logo Genes that share pathways with HTR7: view

Gene Ontology (GO) - Biological Process for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with HTR7: view

No data available for SIGNOR curated interactions for HTR7 Gene

Drugs & Compounds for HTR7 Gene

(80) Drugs for HTR7 Gene - From: IUPHAR, DGIdb, DrugBank, PharmGKB, Novoseek, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methysergide Approved Pharma Antagonist, antagonist, Target 0
Ziprasidone Approved Pharma Antagonist, agonist, Target, antagonist 140
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Chlorpromazine Approved Pharma Antagonist, antagonist, Target, binder 13
Iloperidone Approved Pharma Antagonist, antagonist, Target Dopamine (D2) and serotonin (5HT2) receptor antagonist 0

(16) Additional Compounds for HTR7 Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Br-LSD
Antagonist
5-HT
Full agonist, Agonist
N-Desmethyleletriptan
AS 19
1000578-26-6
LP 12 hydrochloride
1185136-22-4
genes like me logo Genes that share compounds with HTR7: view

Drug Products

Transcripts for HTR7 Gene

mRNA/cDNA for HTR7 Gene

Unigene Clusters for HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: -

Relevant External Links for HTR7 Gene

GeneLoc Exon Structure for
HTR7
ECgene alternative splicing isoforms for
HTR7

Expression for HTR7 Gene

mRNA expression in normal human tissues for HTR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR7 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for HTR7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR7 Gene



SOURCE GeneReport for Unigene cluster for HTR7 Gene Hs.73739

mRNA Expression by UniProt/SwissProt for HTR7 Gene

P34969-5HT7R_HUMAN
Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
genes like me logo Genes that share expression patterns with HTR7: view

Protein tissue co-expression partners for HTR7 Gene

Primer Products

In Situ Assay Products

Orthologs for HTR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR7 36
  • 97 (a)
OneToOne
HTR7 35
  • 99.37 (n)
  • 99.79 (a)
cow
(Bos Taurus)
Mammalia HTR7 36
  • 90 (a)
OneToOne
HTR7 35
  • 91.49 (n)
  • 95.59 (a)
dog
(Canis familiaris)
Mammalia HTR7 35
  • 91.28 (n)
  • 96.06 (a)
HTR7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr7 36
  • 94 (a)
OneToOne
Htr7 16
Htr7 35
  • 90.88 (n)
  • 95.63 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR7 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr7 35
  • 90.82 (n)
  • 96.76 (a)
chicken
(Gallus gallus)
Aves HTR7 35
  • 79.17 (n)
  • 84.56 (a)
HTR7 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR7 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia htr7-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia htr7 35
  • 70.18 (n)
  • 80.58 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC562111 35
  • 73.04 (n)
  • 83.66 (a)
HTR7 (1 of 4) 36
  • 66 (a)
OneToMany
HTR7 (2 of 4) 36
  • 66 (a)
OneToMany
HTR7 (3 of 4) 36
  • 79 (a)
OneToMany
HTR7 (4 of 4) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT7 35
  • 53.69 (n)
  • 43.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 36
  • 29 (a)
OneToOne
CG6919 37
  • 38 (a)
CG7431 37
  • 41 (a)
5-HT7 35
  • 55.82 (n)
  • 46.69 (a)
worm
(Caenorhabditis elegans)
Secernentea ser-7 36
  • 27 (a)
OneToOne
C09B7.1a 37
  • 32 (a)
C09B7.1b 37
  • 32 (a)
M03F4.3 37
  • 39 (a)
ser-7 35
  • 49.3 (n)
  • 36.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for HTR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR7 Gene

ENSEMBL:
Gene Tree for HTR7 (if available)
TreeFam:
Gene Tree for HTR7 (if available)

Paralogs for HTR7 Gene

Pseudogenes.org Pseudogenes for HTR7 Gene

genes like me logo Genes that share paralogs with HTR7: view

Variants for HTR7 Gene

Sequence variations from dbSNP and Humsavar for HTR7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_012995 -
rs114969659 - 90,749,298(+) CTCGA(A/G)GGAAG reference, missense
rs33954285 - 90,743,643(-) GCCAC(A/C/G/T)GGTAT intron-variant, reference, missense
rs1045949 -- 90,740,967(-) TTGCT(A/G)AAGTG utr-variant-3-prime
rs1342085 -- 90,819,499(-) GATGA(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR7 Gene

Variant ID Type Subtype PubMed ID
esv2422237 CNV Duplication 17116639
nsv467432 CNV Gain 19166990
nsv516743 CNV Gain 19592680
nsv831945 CNV Gain 17160897
esv1923742 CNV Deletion 18987734
esv2739474 CNV Deletion 23290073
esv26200 CNV Loss 19812545

Variation tolerance for HTR7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR7 Gene

HapMap Linkage Disequilibrium report
HTR7
Human Gene Mutation Database (HGMD)
HTR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR7 Gene

Disorders for HTR7 Gene

MalaCards: The human disease database

(45) MalaCards diseases for HTR7 Gene - From: GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autistic disorder
  • autism
periodic fever, menstrual cycle dependent
  • periodic fever, menstrual cycle-dependent
coronary artery vasospasm
  • coronary artery spasm
byssinosis
  • cotton mill fever
barbiturate dependence
- elite association - COSMIC cancer census association via MalaCards
Search HTR7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR7

Genetic Association Database (GAD)
HTR7
Human Genome Epidemiology (HuGE) Navigator
HTR7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR7
genes like me logo Genes that share disorders with HTR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR7 Gene

Publications for HTR7 Gene

  1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PMID: 8226867) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. (PMID: 18308814) Shahid M. … Wong E.H. (J. Psychopharmacol. (Oxford) 2009) 23 25
  3. Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes. (PMID: 18992242) Sharif N.A. … Camras C. (Exp. Eye Res. 2009) 25 26
  4. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. (PMID: 18996971) Knight J.A. … Teitler M. (Mol. Pharmacol. 2009) 25 26
  5. Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. (PMID: 19337725) Abbas A.I. … Roth B.L. (Psychopharmacology (Berl.) 2009) 25 26

Products for HTR7 Gene

Sources for HTR7 Gene

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