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Aliases for HTR7 Gene

Aliases for HTR7 Gene

  • 5-Hydroxytryptamine Receptor 7 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled) 2 3
  • 5-HT-7 3 4
  • 5-HT-X 3 4
  • 5-HT7 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled 2
  • Serotonin Receptor 7 4

External Ids for HTR7 Gene

Previous GeneCards Identifiers for HTR7 Gene

  • GC10M091383
  • GC10M091723
  • GC10M092631
  • GC10M092165
  • GC10M092490
  • GC10M086129

Summaries for HTR7 Gene

Entrez Gene Summary for HTR7 Gene

  • The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR7 Gene

HTR7 (5-Hydroxytryptamine Receptor 7) is a Protein Coding gene. Diseases associated with HTR7 include Autistic Disorder and Byssinosis. Among its related pathways are Serotonergic synapse and Circadian rythm related genes. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot for HTR7 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Tocris Summary for HTR7 Gene

  • Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation.

Gene Wiki entry for HTR7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR7 Gene

Genomics for HTR7 Gene

Regulatory Elements for HTR7 Gene

Enhancers for HTR7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G090911 1.3 Ensembl ENCODE dbSUPER 15.8 -54.3 -54315 2.1 CTCF ZNF146 ZNF792 SAP130 ZNF837 ZNF133 TEAD4 ZNF384 ZNF2 RAD21 HTR7 RPP30 GC10M090914 PIR41318
GH10G090833 1 ENCODE dbSUPER 18.8 +23.4 23419 1.1 CTCF FOXA2 PKNOX1 SIN3A ZSCAN5C ZSCAN29 PHF8 CHD1 ZEB2 FOXA1 HTR7 RPP30 PIR38191
GH10G090813 1.1 ENCODE 16.3 +44.1 44093 1.4 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS ZNF548 ZNF263 RPP30 HTR7 TNKS2 NUDT9P1 PIR38191 PIR51660
GH10G090816 0.8 Ensembl ENCODE 19.5 +40.2 40227 2.5 FOSL1 JUND ATF3 IKZF1 CEBPB HMBOX1 ZBTB33 HTR7 PIR38191 PIR51660
GH10G090751 0.7 ENCODE 17.6 +106.3 106336 0.2 SCRT1 CTCF ZNF654 TRIM22 ZFP37 REST RAD21 SCRT2 SMC3 HNF4A HTR7 RPP30 GC10M090736 GC10M090737 GC10M090738 GC10M090739 PIR51660
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR7 on UCSC Golden Path with GeneCards custom track

Promoters for HTR7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000031492 -186 1401 ZSCAN5A CTCF MXI1 SUZ12 RBBP5 BMI1 ZNF48 ZBTB40 ZFHX2 ZNF143

Genomic Location for HTR7 Gene

Chromosome:
10
Start:
90,740,818 bp from pter
End:
90,857,914 bp from pter
Size:
117,097 bases
Orientation:
Minus strand

Genomic View for HTR7 Gene

Genes around HTR7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR7 Gene

Proteins for HTR7 Gene

  • Protein details for HTR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34969-5HT7R_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 7
    Protein Accession:
    P34969
    Secondary Accessions:
    • B5BUP6
    • P78336
    • P78372
    • P78516
    • Q5VX01
    • Q5VX02
    • Q5VX03

    Protein attributes for HTR7 Gene

    Size:
    479 amino acids
    Molecular mass:
    53555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HTR7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR7 Gene

Post-translational modifications for HTR7 Gene

  • Glycosylation at posLast=55 and isoforms=2, 366
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR7 Gene

No data available for DME Specific Peptides for HTR7 Gene

Domains & Families for HTR7 Gene

Graphical View of Domain Structure for InterPro Entry

P34969

UniProtKB/Swiss-Prot:

5HT7R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR7: view

Function for HTR7 Gene

Molecular function for HTR7 Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate cyclase,unlikely to be associated with autistic disorder
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Gene Ontology (GO) - Molecular Function for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA,TAS --
GO:0030594 neurotransmitter receptor activity IBA --
GO:0051378 serotonin binding IBA --
genes like me logo Genes that share ontologies with HTR7: view
genes like me logo Genes that share phenotypes with HTR7: view

Animal Models for HTR7 Gene

MGI Knock Outs for HTR7:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR7

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR7 Gene

Localization for HTR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR7 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8226867
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR7: view

Pathways & Interactions for HTR7 Gene

genes like me logo Genes that share pathways with HTR7: view

Gene Ontology (GO) - Biological Process for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8226867
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with HTR7: view

No data available for SIGNOR curated interactions for HTR7 Gene

Drugs & Compounds for HTR7 Gene

(90) Drugs for HTR7 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methysergide Approved Pharma Antagonist, antagonist, Target 0
Ziprasidone Approved Pharma Antagonist, agonist, Target, antagonist 5-HT (serotonin)/dopamine receptor antagonist 145
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication 117
Chlorpromazine Approved, Vet_approved Pharma Antagonist, antagonist, Target, binder 18
Iloperidone Approved Pharma Antagonist, antagonist, Target Dopamine (D2) and serotonin (5HT2) receptor antagonist 0

(12) Additional Compounds for HTR7 Gene - From: HMDB, IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Br-LSD
Antagonist
5-HT
Full agonist, Agonist
N-Desmethyleletriptan
SB 269970 hydrochloride
261901-57-9

(5) Tocris Compounds for HTR7 Gene

Compound Action Cas Number
8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist; also has moderate affinity for 5-HT7 76135-31-4
AS 19 Potent 5-HT7 agonist 1000578-26-6
LP 44 High affinity 5-HT7 agonist 824958-12-5
SB 258719 hydrochloride Selective 5-HT7 antagonist 1217674-10-6
SB 269970 hydrochloride Potent and selective 5-HT7 antagonist; brain penetrant 261901-57-9

(10) ApexBio Compounds for HTR7 Gene

Compound Action Cas Number
AS 19 Potent 5-HT7 agonist 1000578-26-6
DR 4485 hydrochloride 402942-53-4
LP 12 hydrochloride 1185136-22-4
LP 20 hydrochloride 1386928-34-2
LP 44 824958-12-5
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
LY 215840 137328-52-0
Metergoline 17692-51-2
SB-269970 5-HT7 receptor antagonist 201038-74-6
SB269970 HCl 5-HT7 receptor antagonist,potent and selective 261901-57-9
genes like me logo Genes that share compounds with HTR7: view

Drug Products

Transcripts for HTR7 Gene

mRNA/cDNA for HTR7 Gene

Unigene Clusters for HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR7

Alternative Splicing Database (ASD) splice patterns (SP) for HTR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3: -

Relevant External Links for HTR7 Gene

GeneLoc Exon Structure for
HTR7
ECgene alternative splicing isoforms for
HTR7

Expression for HTR7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR7 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for HTR7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR7 Gene



Protein tissue co-expression partners for HTR7 Gene

NURSA nuclear receptor signaling pathways regulating expression of HTR7 Gene:

HTR7

SOURCE GeneReport for Unigene cluster for HTR7 Gene:

Hs.73739

mRNA Expression by UniProt/SwissProt for HTR7 Gene:

P34969-5HT7R_HUMAN
Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.

Evidence on tissue expression from TISSUES for HTR7 Gene

  • Nervous system(4.9)
  • Muscle(3.1)
  • Blood(2.9)
  • Intestine(2.9)
  • Heart(2.7)
  • Stomach(2.5)
  • Lung(2.4)
  • Adrenal gland(2.3)
  • Kidney(2.2)
  • Liver(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with HTR7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR7 Gene

Orthologs for HTR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR7 35 34
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HTR7 34 35
  • 91.49 (n)
dog
(Canis familiaris)
Mammalia HTR7 34 35
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Htr7 16 35 34
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Htr7 34
  • 90.82 (n)
oppossum
(Monodelphis domestica)
Mammalia HTR7 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR7 34 35
  • 79.17 (n)
lizard
(Anolis carolinensis)
Reptilia HTR7 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr7 34
  • 70.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia htr7-A 34
zebrafish
(Danio rerio)
Actinopterygii HTR7 (3 of 4) 35
  • 79 (a)
OneToMany
LOC562111 34
  • 73.04 (n)
HTR7 (4 of 4) 35
  • 73 (a)
OneToMany
HTR7 (2 of 4) 35
  • 66 (a)
OneToMany
HTR7 (1 of 4) 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT7 34 35
  • 55.82 (n)
CG7431 36
  • 41 (a)
CG6919 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT7 34
  • 53.69 (n)
worm
(Caenorhabditis elegans)
Secernentea ser-7 34 35
  • 49.3 (n)
M03F4.3 36
  • 39 (a)
C09B7.1a 36
  • 32 (a)
C09B7.1b 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for HTR7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR7 Gene

ENSEMBL:
Gene Tree for HTR7 (if available)
TreeFam:
Gene Tree for HTR7 (if available)

Paralogs for HTR7 Gene

Pseudogenes.org Pseudogenes for HTR7 Gene

genes like me logo Genes that share paralogs with HTR7: view

Variants for HTR7 Gene

Sequence variations from dbSNP and Humsavar for HTR7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000008358 -- 90,803,651(+) CTGAC(A/C)ATCAT intron-variant
rs1000057222 -- 90,838,352(+) CCTGC(C/T)GATAC intron-variant
rs1000058477 -- 90,745,320(+) CTTAC(A/G)TGGTA intron-variant
rs1000110615 -- 90,756,316(+) ATTCA(A/G)TTATG intron-variant
rs1000118211 -- 90,832,052(+) CAATC(C/T)CTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR7 Gene

Variant ID Type Subtype PubMed ID
dgv1338n54 CNV gain 21841781
dgv1346n54 CNV gain 21841781
dgv952n100 CNV gain 25217958
esv1923742 CNV deletion 18987734
esv2422237 CNV duplication 17116639
esv26200 CNV loss 19812545
esv2739474 CNV deletion 23290073
esv3390334 CNV insertion 20981092
esv3394038 CNV insertion 20981092
esv3624194 CNV loss 21293372
nsv1036058 CNV gain 25217958
nsv467432 CNV gain 19166990
nsv516743 CNV gain 19592680
nsv831945 CNV gain 17160897

Variation tolerance for HTR7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR7 Gene

Human Gene Mutation Database (HGMD)
HTR7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR7 Gene

Disorders for HTR7 Gene

MalaCards: The human disease database

(40) MalaCards diseases for HTR7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autistic disorder
  • autism
byssinosis
  • cotton mill fever
barbiturate dependence
psychosexual disorder
  • psychosexual disorders
functional colonic disease
  • colonic diseases, functional
- elite association - COSMIC cancer census association via MalaCards
Search HTR7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR7

Genetic Association Database (GAD)
HTR7
Human Genome Epidemiology (HuGE) Navigator
HTR7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR7
genes like me logo Genes that share disorders with HTR7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR7 Gene

Publications for HTR7 Gene

  1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PMID: 8226867) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. (PMID: 17406648) Cross S. … Veenstra-Vanderweele J. (Neuropsychopharmacology 2008) 3 22 46 64
  3. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. (PMID: 16192982) Ikeda M. … Ozaki N. (Neuropsychopharmacology 2006) 3 22 46 64
  4. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M. … Kennedy J.L. (Schizophr. Res. 2001) 3 22 46 64
  5. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. (PMID: 9084407) Heidmann D.E.A. … Hamblin M.W. (J. Neurochem. 1997) 3 4 22 64

Products for HTR7 Gene

  • Addgene plasmids for HTR7

Sources for HTR7 Gene

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