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Aliases for HTR7 Gene

Aliases for HTR7 Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled) 2 3
  • 5-HT-7 3 4
  • 5-HT-X 3 4
  • 5-HT7 3 4
  • 5-Hydroxytryptamine Receptor 7 3
  • Serotonin Receptor 7 4

External Ids for HTR7 Gene

Previous GeneCards Identifiers for HTR7 Gene

  • GC10M091383
  • GC10M091723
  • GC10M092631
  • GC10M092165
  • GC10M092490
  • GC10M086129

Summaries for HTR7 Gene

Entrez Gene Summary for HTR7 Gene

  • The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR7 Gene

HTR7 (5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled) is a Protein Coding gene. Diseases associated with HTR7 include autistic disorder. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR7 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Tocris Summary for HTR7 Gene

  • Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, learning and memory and smooth muscle relaxation. The human 5-HT7 receptor gene has been localized to chromosome 10 (10q21-24).

Gene Wiki entry for HTR7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR7 Gene

Genomics for HTR7 Gene

Regulatory Elements for HTR7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR7 Gene

90,740,818 bp from pter
90,857,914 bp from pter
117,097 bases
Minus strand

Genomic View for HTR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR7 Gene

Proteins for HTR7 Gene

  • Protein details for HTR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 7
    Protein Accession:
    Secondary Accessions:
    • B5BUP6
    • P78336
    • P78372
    • P78516
    • Q5VX01
    • Q5VX02
    • Q5VX03

    Protein attributes for HTR7 Gene

    479 amino acids
    Molecular mass:
    53555 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HTR7 Gene


neXtProt entry for HTR7 Gene

Proteomics data for HTR7 Gene at MOPED

Post-translational modifications for HTR7 Gene

  • Glycosylation at Asn5 and Asn66
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR7 Gene

Domains for HTR7 Gene

Gene Families for HTR7 Gene

  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
  • HTR :5-HT (serotonin) receptors

Graphical View of Domain Structure for InterPro Entry



  • P34969
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR7: view

Function for HTR7 Gene

Molecular function for HTR7 Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate cyclase,unlikely to be associated with autistic disorder
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Gene Ontology (GO) - Molecular Function for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IEA --
genes like me logo Genes that share ontologies with HTR7: view
genes like me logo Genes that share phenotypes with HTR7: view

Animal Models for HTR7 Gene

MGI Knock Outs for HTR7:

Animal Model Products

miRNA for HTR7 Gene

miRTarBase miRNAs that target HTR7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR7 Gene

Localization for HTR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HTR7 Gene COMPARTMENTS Subcellular localization image for HTR7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8226867
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR7: view

Pathways for HTR7 Gene

genes like me logo Genes that share pathways with HTR7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HTR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006939 smooth muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8226867
GO:0007210 serotonin receptor signaling pathway TAS 8226867
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR7: view

Compounds for HTR7 Gene

Compound Products

(5) Tocris Compounds for HTR7 Gene

Compound Action Cas Number
8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist; also has moderate affinity for 5-HT7 [76135-31-4]
AS 19 Potent 5-HT7 agonist [1000578-26-6]
LP 44 High affinity 5-HT7 agonist [824958-12-5]
SB 258719 hydrochloride Selective 5-HT7 antagonist [1217674-10-6]
SB 269970 hydrochloride Potent and selective 5-HT7 antagonist; brain penetrant [261901-57-9]

(2) ApexBio Compounds for HTR7 Gene

Compound Action Cas Number
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor [367514-88-3]
SB269970 HCl "5-HT7 receptor antagonist,potent and selective" [261901-57-9]

(1) HMDB Compounds for HTR7 Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-(2-Aminoethyl)-1H-indol-5-ol

(14) Drugbank Compounds for HTR7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
53583-79-2 target antagonist
  • OPC 31
129722-12-9 target antagonist
65576-45-6 target antagonist
  • Bromergocryptine
25614-03-3 target antagonist
  • Cabergolina [Spanish]
81409-90-7 target antagonist

(50) IUPHAR Ligand for HTR7 Gene

Ligand Type Action Affinity Pubmed IDs
SB 207710 Antagonist Antagonist 10.3
cyproheptadine Antagonist Antagonist 10.2
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
[3H]5-HT Agonist Full agonist 9
(+)-LSD Agonist Full agonist 9
[3H]SB269970 Antagonist Antagonist 8.92
SB269970 Antagonist Antagonist 8.9
SB656104 Antagonist Antagonist 8.7
[3H]LSD Agonist Full agonist 8.7
E55888 Agonist Full agonist 8.6
oleamide Allosteric regulator Negative 8.6
pirenperone Antagonist Antagonist 8.5
perphenazine Antagonist Antagonist 8.1
1-naphthylpiperazine Agonist Full agonist 8
risperidone Antagonist Antagonist 7.8
ziprasidone Antagonist Antagonist 7.8
EMDT Agonist Full agonist 7.8
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
MPDT Antagonist Antagonist 7.7
2-Br-LSD Antagonist Antagonist 7.5
SB 258719 Antagonist Inverse agonist 7.5
fluperlapine Antagonist Inverse agonist 7.5
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
yohimbine Antagonist Antagonist 7.3
iloperidone Antagonist Antagonist 7.2
tryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
5-MeOT Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
spiperone Antagonist Antagonist 6.7
clozapine Antagonist Antagonist 6.7
cyamemazine Antagonist Antagonist 6.3
ketanserin Inhibitor Inhibition 6.3
LY344864 Agonist Full agonist 6.3
5-CT Agonist Full agonist 6.1
haloperidol Antagonist Antagonist 6.1
xanomeline Agonist Full agonist 5.9
dipropyl-5-CT Agonist Full agonist 5.8
mesulergine Antagonist Antagonist 5.7
sumatriptan Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
[3H]5-CT Agonist Agonist
chlorpromazine Channel blocker None

(16) Novoseek inferred chemical compound relationships for HTR7 Gene

Compound -log(P) Hits PubMed IDs
way 100635 82.8 3
5-hydroxytryptamine 79.2 9
gr 127935 67.5 1
metergoline 64.7 1
sumatriptan 62.1 2

(4) PharmGKB related drug/compound annotations for HTR7 Gene

Drug/compound Annotation
atorvastatin CA
hmg coa reductase inhibitors CA
pravastatin CA
simvastatin CA
genes like me logo Genes that share compounds with HTR7: view

Transcripts for HTR7 Gene

mRNA/cDNA for HTR7 Gene

Unigene Clusters for HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -
SP3: -

Relevant External Links for HTR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR7 Gene

mRNA expression in normal human tissues for HTR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR7 Gene

This gene is overexpressed in Testis (8.8).

Protein differential expression in normal tissues for HTR7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR7 Gene

SOURCE GeneReport for Unigene cluster for HTR7 Gene Hs.73739

mRNA Expression by UniProt/SwissProt for HTR7 Gene

Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
genes like me logo Genes that share expressions with HTR7: view

Expression partners for HTR7 Gene

In Situ Assay Products

Orthologs for HTR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HTR7 35
  • 91.49 (n)
  • 95.59 (a)
HTR7 36
  • 90 (a)
(Canis familiaris)
Mammalia HTR7 35
  • 91.28 (n)
  • 96.06 (a)
HTR7 36
  • 91 (a)
(Mus musculus)
Mammalia Htr7 35
  • 90.88 (n)
  • 95.63 (a)
Htr7 16
Htr7 36
  • 94 (a)
(Pan troglodytes)
Mammalia HTR7 35
  • 99.37 (n)
  • 99.79 (a)
HTR7 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Htr7 35
  • 90.82 (n)
  • 96.76 (a)
(Monodelphis domestica)
Mammalia HTR7 36
  • 84 (a)
(Gallus gallus)
Aves HTR7 35
  • 79.17 (n)
  • 84.56 (a)
HTR7 36
  • 76 (a)
(Anolis carolinensis)
Reptilia HTR7 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr7 35
  • 70.18 (n)
  • 80.58 (a)
African clawed frog
(Xenopus laevis)
Amphibia htr7-A 35
(Danio rerio)
Actinopterygii LOC562111 35
  • 73.04 (n)
  • 83.66 (a)
HTR7 (1 of 4) 36
  • 66 (a)
HTR7 (2 of 4) 36
  • 66 (a)
HTR7 (3 of 4) 36
  • 79 (a)
HTR7 (4 of 4) 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 38 (a)
CG7431 37
  • 41 (a)
5-HT7 35
  • 55.82 (n)
  • 46.69 (a)
5-HT7 36
  • 29 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT7 35
  • 53.69 (n)
  • 43.42 (a)
(Caenorhabditis elegans)
Secernentea C09B7.1a 37
  • 32 (a)
C09B7.1b 37
  • 32 (a)
M03F4.3 37
  • 39 (a)
ser-7 35
  • 49.3 (n)
  • 36.53 (a)
ser-7 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for HTR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR7 Gene

Gene Tree for HTR7 (if available)
Gene Tree for HTR7 (if available)

Paralogs for HTR7 Gene Pseudogenes for HTR7 Gene

genes like me logo Genes that share paralogs with HTR7: view

Variants for HTR7 Gene

Sequence variations from dbSNP and Humsavar for HTR7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs955064 -- 90,782,742(-) TGTAC(A/C)TGTCA intron-variant
rs1045949 -- 90,740,967(-) TTGCT(A/G)AAGTG utr-variant-3-prime
rs1342085 -- 90,819,499(-) GATGA(C/T)GTACT intron-variant
rs1418212 -- 90,771,843(+) GCAAA(C/G)GCACC intron-variant
rs1418213 -- 90,741,893(+) CATAG(A/G)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR7 Gene

Variant ID Type Subtype PubMed ID
esv2422237 CNV Duplication 17116639
nsv467432 CNV Gain 19166990
nsv516743 CNV Gain 19592680
nsv831945 CNV Gain 17160897
esv1923742 CNV Deletion 18987734
esv2739474 CNV Deletion 23290073
esv26200 CNV Loss 19812545

Relevant External Links for HTR7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR7 Gene

Disorders for HTR7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTR7 Gene in MalaCards »

(1) Diseases for HTR7 Gene including...

(2) Novoseek inferred disease relationships for HTR7 Gene

Disease -log(P) Hits PubMed IDs
migraine 32.2 1
schizophrenia 19.9 1

Relevant External Links for HTR7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HTR7 Gene

Publications for HTR7 Gene

  1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PMID: 8226867) Bard J.A. … Weinshank R.L. (J. Biol. Chem. 1993) 2 3 4 23
  2. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PMID: 11163544) Masellis M. … Kennedy J.L. (Schizophr. Res. 2001) 3 23 48
  3. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. (PMID: 9084407) Heidmann D.E.A. … Hamblin M.W. (J. Neurochem. 1997) 3 4 23
  4. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. (PMID: 17406648) Cross S. … Veenstra-Vanderweele J. (Neuropsychopharmacology 2008) 3 23 48
  5. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. (PMID: 16192982) Ikeda M. … Ozaki N. (Neuropsychopharmacology 2006) 3 23 48

Products for HTR7 Gene

Sources for HTR7 Gene

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