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HTR7 Gene

protein-coding   GIFtS: 70
GCID: GC10M092490

5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate
Cyclase-Coupled1 2
     5-HT72 3
5-Hydroxytryptamine (Serotonin) Receptor 7 (Adenylate Cyclase-Coupled)1 2     5-Hydroxytryptamine Receptor 72
5-HT-72 3     Serotonin Receptor 73
5-HT-X2 3     

External Ids:    HGNC: 53021   Entrez Gene: 33632   Ensembl: ENSG000001486807   OMIM: 1821375   UniProtKB: P349693   

Export aliases for HTR7 gene to outside databases

Previous GC identifers: GC10M091383 GC10M091723 GC10M092631 GC10M092165 GC10M086129


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR7 Gene:
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The
serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is
a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice
variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HTR7 Gene:
HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled) is a protein-coding gene. Diseases associated with HTR7 include autistic disorder, and premature ejaculation. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT7R_HUMAN, P34969
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins that stimulate adenylate cyclase

summary for HTR7 Gene:
Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function
of these receptors includes the regulation of circadian rhythms, learning and memory and smooth muscle
relaxation. The human 5-HT7 receptor gene has been localized to chromosome 10 (10q21-24).

Gene Wiki entry for HTR7 (5-HT7 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR7 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR7 promoter sequence
   Search Chromatin IP Primers for HTR7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21-q24   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q21-q24

HTR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR7 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M092490:  view genomic region     (about GC identifiers)

Start:
92,500,575 bp from pter      End:
92,617,671 bp from pter
Size:
117,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT7R_HUMAN, P34969 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 7  
Size: 479 amino acids; 53555 Da
Secondary accessions: B5BUP6 P78336 P78372 P78516 Q5VX01 Q5VX02 Q5VX03
Alternative splicing: 3 isoforms:  P34969-1   P34969-2   P34969-3   

Explore the universe of human proteins at neXtProt for HTR7: NX_P34969

Explore proteomics data for HTR7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn66

  • See HTR7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000863.1  NP_062873.1  NP_062874.1  

    ENSEMBL proteins: 
     ENSP00000337949   ENSP00000277874   ENSP00000360784   ENSP00000360786  
    Reactome Protein details: P34969

    HTR7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HTR7
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    Novus Biologicals HTR7 Proteins
    Novus Biologicals HTR7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR7

    HTR7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HTR7
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    HTR7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HTR7
    Cloud-Clone Corp. CLIAs for HTR7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT7 receptor
    5-Hydroxytryptamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001069 5HT_7_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34969

    ProtoNet protein and cluster: P34969

    2 Blocks protein domains:
    IPB001069 5-hydroxytryptamine 7 receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT7R_HUMAN, P34969
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT7R_HUMAN, P34969
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins that stimulate adenylate cyclase

         Genatlas biochemistry entry for HTR7:
    5-hydroxytryptamine (serotonin) receptor,subtype 7,G protein coupled receptor superfamily,activating adenylate
    cyclase,unlikely to be associated with autistic disorder

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IEA--
         
    HTR7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR7:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Htr7):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  nervous system 

    HTR7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR7: Htr7tm1Mrg Htr7tm1Wtkn Htr7tm1Lex Htr7tm1Sut

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR7

    miRNA
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    miRTarBase miRNAs that target HTR7:
    hsa-mir-335-5p (MIRT016917)

    Block miRNA regulation of human, mouse, rat HTR7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTR7 (see all 28):
    hsa-miR-579 hsa-miR-640 hsa-miR-136 hsa-miR-330-5p hsa-miR-4272 hsa-miR-4263 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidHTR7 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HTR7

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): HTR7 (NM_000872)
    Sino Biological Human cDNA Clone for HTR7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HTR7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT7R_HUMAN, P34969: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8226867
    GO:0016021integral component of membrane ----

    HTR7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR7 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Transcription CREB pathway
    Development Ligand independent activation of ESR1 and ESR20.34
    Transcription CREB pathway0.34
    5CREB Pathway
    Intracellular Calcium Signaling0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR7
        Intracellular Calcium Signaling

    2 GeneGo (Thomson Reuters) Pathways for HTR7
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway

    4 BioSystems Pathways for HTR7
        Serotonin Receptor 4/6/7 and NR3C Signaling
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs


    2 Reactome Pathways for HTR7
        Serotonin receptors
    G alpha (s) signalling events

    1 PharmGKB Pathway for HTR7
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for HTR7):
        Ras signaling pathway
    Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR7: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Circadian Rhythms in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR7 (P349693 ENSP000003379494) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP2Q96D093, ENSP000003390574I2D: score=3 STRING: ENSP00000339057
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006939smooth muscle contraction IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8226867
    GO:0007210serotonin receptor signaling pathway TAS8226867
    GO:0007268synaptic transmission IEA--

    HTR7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HTR7
      Browse compounds at ApexBio 

    Compounds for HTR7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 258719 hydrochlorideSelective 5-HT7 antagonist[195199-95-2]
    AS 19Reported potent 5-HT7 agonist[1000578-26-6]
    SB 269970 hydrochloridePotent selective 5-HT7 antagonist. Brain penetrant[201038-74-6]
    LP 44High affinity 5-HT7 agonist[824958-12-5]
    8-Hydroxy-DPAT hydrobromideSelective 5-HT1A agonist. Also has moderate affinity for 5-HT7[76135-31-4]

    1 HMDB Compound for HTR7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    Selected DrugBank Compounds for HTR7 (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist17242925 7583621 10432496
    Asenapine-- 65576-45-6targetantagonist21655346 18308814
    Eletriptan-- 143322-58-1targetagonist17139284 17016423
    Amisulpride-- 53583-79-2targetantagonist19337725
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist17848919
    BromocriptineBromergocryptine (see all 10)25614-03-3targetantagonist18996971
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetantagonist18992242
    Clozapine-- 5786-21-0targetantagonist17848919
    EpinastineEpinastina [Spanish] (see all 2)80012-43-7targetantagonist10596692
    Iloperidone-- 133454-47-4targetantagonist23272794

    Selected IUPHAR Ligands for HTR7 (5-HT7 receptor) (see all 50)    About this table
    LigandTypeActionAffinityPubmed IDs
    5-CT
    AgonistFull agonist9 - 1011414657 9298538 8226867 9720804
    5-HT
    AgonistFull agonist8.1 - 9.611414657 12527336 9298538 8226867 9720804
    5-MeOT
    AgonistFull agonist8.3 - 9.511414657 9298538 8226867
    methiothepin
    AntagonistAntagonist8.4 - 9.411414657 9298538 8226867 9720804
    [3H]5-CT
    AgonistAgonist9.410807680
    [3H]5-HT
    AgonistFull agonist8.1 - 99303561 8226867
    [3H]SB269970
    AntagonistAntagonist8.9210807680
    SB269970
    AntagonistAntagonist8.6 - 8.910807680
    metergoline
    AntagonistAntagonist8.2 - 8.911414657 9298538 8226867
    SB656104
    AntagonistAntagonist8.712392747

    Selected Novoseek inferred chemical compound relationships for HTR7 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    way 100635 82.8 3 14684258 (1), 16166271 (1), 17224282 (1)
    5-hydroxytryptamine 79.2 32 10643820 (1), 16319916 (1), 19248248 (1), 19995401 (1) (see all 9)
    gr 127935 67.5 1 17224282 (1)
    metergoline 64.7 1 12930783 (1)
    sumatriptan 62.1 2 11293643 (1), 8744664 (1)
    8-hydroxy-2-(di-n-propylamino)tetralin 53.7 1 9817696 (1)
    clozapine 52.3 3 7961573 (1), 9463841 (1), 11163544 (1)
    aripiprazole 41.3 2 12784105 (1), 16395846 (1)
    dopamine 26.2 5 18308814 (1), 19426122 (1), 11212112 (1), 12815163 (1)
    acetylcholine 20.8 1 16166271 (1)

    4 PharmGKB related drug/compound annotations for HTR7 gene    About this table
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    hmg coa reductase inhibitorsCA  
    pravastatinCA  
    simvastatinCA  



    HTR7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR7 gene (3 alternative transcripts): 
    NM_000872.4  NM_019859.3  NM_019860.3  

    Unigene Cluster for HTR7:

    5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
    Hs.73739  [show with all ESTs]
    Unigene Representative Sequence: NM_019859
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336152(uc001kha.3) ENST00000277874(uc001kgz.3) ENST00000371719(uc001khb.3)
    ENST00000371721
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HTR7 (see all 28):
    hsa-miR-579 hsa-miR-640 hsa-miR-136 hsa-miR-330-5p hsa-miR-4272 hsa-miR-4263 hsa-miR-29a hsa-miR-29c
    SwitchGear 3'UTR luciferase reporter plasmidHTR7 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 3): HTR7 (NM_000872)
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      QuantiFast Probe-based Assays in human, mouse, rat HTR7

    Additional mRNA sequence: 

    AB451482.1 AK292606.1 AY493988.1 BC047526.1 L21195.1 U68487.1 U68488.1 

    3 DOTS entries:

    DT.100745199  DT.412014  DT.310676 

    Selected AceView cDNA sequences (see all 31):

    AY493988 NM_019859 NM_019860 U68488 U68487 NM_000872 BC047526 F04627 
    AA397967 AL042388 L21195 BG108256 AI359877 BI559584 BQ229408 F08412 
    BF594098 BV202561 BU633788 BI562260 R51124 AW590184 R50890 R50773 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HTR7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                    -               
    SP3:                    -               


    ECgene alternative splicing isoforms for HTR7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR7 Expression
    About this image


    HTR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    HTR7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73739

    UniProtKB/Swiss-Prot: 5HT7R_HUMAN, P34969
    Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is
    expressed at lower levels. Isoform D is a minor isoform in term of expression

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr71 , 5 5-hydroxytryptamine (serotonin) receptor 71, 5 90.88(n)1
    95.63(a)1
      19 (30.30 cM)5
    155661  NM_008315.21  NP_032341.21 
     359587345 
    chicken
    (Gallus gallus)
    Aves HTR71 5-hydroxytryptamine (serotonin) receptor 7, adenylate more 79.17(n)
    84.56(a)
      423794  NM_001174134.1  NP_001167605.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR76
    5-hydroxytryptamine (serotonin) receptor 7, adenyl...
    88(a)
    1 ↔ 1
    GL343219.1(567977-585051)
    African clawed frog
    (Xenopus laevis)
    Amphibia htr7-A2 hydroxytryptamine (serotonin) receptor 7 (adenylate more 75.08(n)    U10161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5621111 5-hydroxytryptamine receptor 7-like 73.04(n)
    83.66(a)
      562111  XM_685507.6  XP_690599.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74313
    5-HT71
    G-protein coupled receptor protein
    signaling pathway more3
    Serotonin receptor 71
    41(a)
    (best of 2)3
    55.82(n)1
    46.69(a)1
      436691  NM_001276202.11  NP_001263131.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33
    ser-71
    G-protein coupled receptor3
    ser-71
    39(a)
    (best of 3)3
    49.3(n)1
    36.53(a)1
      X(4985611-4990413)3
    1805651  NM_171637.41  NP_741730.11 


    ENSEMBL Gene Tree for HTR7 (if available)
    TreeFam Gene Tree for HTR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR7 gene
    HTR1A2  ADRA1B2  HTR1F2  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for HTR7 using alignment to 2 protein entries:     5HT7R_HUMAN (see all proteins) (see all similar genes):
    5-HT7    HTR5A    ADRA1B    HRH3    alpha 1c-adrenoceptor subtype    HTR1D
    HTR1F    HTR1E    ADRA1D    DRD5P1    HTR1B    HTR2A
    DRD1    ADRB2    HTR4    HTR4B    ADRA1A    DRD2

    HTR7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HTR7
    PGOHUM00000239681


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR7 (see all 2281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766235641,2
    C,F--86129095(+) GTCAAT/CAGTCG 3 -- ds50012Minor allele frequency- C:0.14NA EA 240
    rs1903344191,2
    --86129120(+) GCAGGA/GTAAGG 3 -- ds50010--------
    rs1825523741,2
    --86129134(+) CAATAC/TGAATC 3 -- ds50010--------
    rs18913131,2
    C,F,H--86129265(-) GTATAG/ATAAGT 3 -- ds500117Minor allele frequency- A:0.05NS EA NA WA 1644
    rs1509909021,2
    --86129286(+) CAAATC/TGAGAC 3 -- ds50010--------
    rs1395606441,2
    --86129300(+) TTTGCC/TTTCTA 3 -- ds50010--------
    rs43134831,2
    H--86129301(+) TTGCCT/ATCTAC 3 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1443354121,2
    --86129318(+) GCAAAC/TTCTTA 3 -- ds50010--------
    rs79023531,2
    C,F,H--86129378(+) GCTAAT/GGTGCC 3 -- ds500110Minor allele frequency- G:0.04NS EA NA WA 1212
    rs767934031,2
    --86129449(+) ATAAAA/GTCACT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for HTR7 (92500575 - 92617671 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HTR7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1923742CNV Deletion18987734
    esv2739474CNV Deletion23290073
    esv2422237CNV Duplication17116639
    esv26200CNV Loss19812545
    nsv831945CNV Gain17160897
    nsv467432CNV Gain19166990
    nsv516743CNV Gain19592680

    Human Gene Mutation Database (HGMD): HTR7
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182137    OMIM disorders: --

    Selected diseases for HTR7 (see all 21):    
    About MalaCards
    autistic disorder    premature ejaculation    carcinoid syndrome    irritable bowel syndrome
    substance abuse    chronic fatigue syndrome    eating disorder    headache
    constipation    migraine    cushing's syndrome    temporal lobe epilepsy
    alcohol dependence    anorexia nervosa    diarrhea    meningitis
    schizophrenia    pertussis    cholera    alzheimer's disease


    HTR7 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HTR7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 32.2 1 9523053 (1)
    schizophrenia 19.9 2 16192982 (1)

    Genetic Association Database (GAD): HTR7
    Human Genome Epidemiology (HuGE) Navigator: HTR7 (18 documents)

    Export disorders for HTR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR7 gene, integrated from 10 sources (see all 142):
    (articles sorted by number of sources associating them with HTR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. (PubMed id 8226867)1, 2, 3, 9 Bard J.A....Weinshank R.L. (J. Biol. Chem. 1993)
    2. Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization. (PubMed id 9084407)1, 2, 9 Heidmann D.E.A.... Hamblin M.W. (J. Neurochem. 1997)
    3. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. (PubMed id 16192982)1, 4, 9 Ikeda M....Ozaki N. (Neuropsychopharmacology 2006)
    4. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. (PubMed id 17406648)1, 4, 9 Cross S....Veenstra-Vanderweele J. (Neuropsychopharmacology 2008)
    5. Lack of association between the T--&gt;C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PubMed id 11163544)1, 4, 9 Masellis M....Kennedy J.L. (Schizophr. Res. 2001)
    6. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    10. Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients. (PubMed id 19233240)1, 4 Wei Z....Xing Q. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3363 HGNC: 5302 AceView: HTR7 Ensembl:ENSG00000148680 euGenes: HUgn3363
    ECgene: HTR7 Kegg: 3363 H-InvDB: HTR7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR7 gene:
    Search GeneIP for patents involving HTR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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