Aliases for HTR7 Gene
External Ids for HTR7 Gene
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
GeneCards Summary for HTR7 Gene
HTR7 (5-Hydroxytryptamine (Serotonin) Receptor 7, Adenylate Cyclase-Coupled) is a Protein Coding gene. Diseases associated with HTR7 include autistic disorder. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for HTR7 Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase
Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, learning and memory and smooth muscle relaxation. The human 5-HT7 receptor gene has been localized to chromosome 10 (10q21-24).