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Aliases for HTR6 Gene

Aliases for HTR6 Gene

  • 5-Hydroxytryptamine Receptor 6 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled 2 3 5
  • Serotonin Receptor 6 3 4
  • 5-HT6 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 6 2
  • 5-HT6R 3
  • 5-HT-6 4

External Ids for HTR6 Gene

Previous GeneCards Identifiers for HTR6 Gene

  • GC01P019551
  • GC01P019016
  • GC01P019137
  • GC01P019461
  • GC01P019737
  • GC01P019864
  • GC01P019991
  • GC01P018237

Summaries for HTR6 Gene

Entrez Gene Summary for HTR6 Gene

  • This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

GeneCards Summary for HTR6 Gene

HTR6 (5-Hydroxytryptamine Receptor 6) is a Protein Coding gene. Diseases associated with HTR6 include Acute Stress Disorder and Amnestic Disorder. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and histamine receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for HTR6 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

Tocris Summary for HTR6 Gene

  • Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and a role in spatial learning and memory.

Gene Wiki entry for HTR6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR6 Gene

Genomics for HTR6 Gene

Regulatory Elements for HTR6 Gene

Enhancers for HTR6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTR6 on UCSC Golden Path with GeneCards custom track

Promoters for HTR6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HTR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR6 Gene

Chromosome:
1
Start:
19,665,287 bp from pter
End:
19,680,966 bp from pter
Size:
15,680 bases
Orientation:
Plus strand

Genomic View for HTR6 Gene

Genes around HTR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR6 Gene

Proteins for HTR6 Gene

  • Protein details for HTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50406-5HT6R_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 6
    Protein Accession:
    P50406
    Secondary Accessions:
    • Q13640
    • Q5TGZ1

    Protein attributes for HTR6 Gene

    Size:
    440 amino acids
    Molecular mass:
    46954 Da
    Quaternary structure:
    • Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5 (By similarity).

neXtProt entry for HTR6 Gene

Proteomics data for HTR6 Gene at MOPED

Post-translational modifications for HTR6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR6 Gene

Domains & Families for HTR6 Gene

Protein Domains for HTR6 Gene

Suggested Antigen Peptide Sequences for HTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50406

UniProtKB/Swiss-Prot:

5HT6R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR6: view

Function for HTR6 Gene

Molecular function for HTR6 Gene

GENATLAS Biochemistry:
5-hydroxytrhyptamine (serotonin) receptor,subtype 6,prominently expressed in the caudal nucleus,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).

Gene Ontology (GO) - Molecular Function for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17189269
genes like me logo Genes that share ontologies with HTR6: view
genes like me logo Genes that share phenotypes with HTR6: view

Animal Models for HTR6 Gene

MGI Knock Outs for HTR6:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR6 Gene

Localization for HTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR6 Gene COMPARTMENTS Subcellular localization image for HTR6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8522988
genes like me logo Genes that share ontologies with HTR6: view

Pathways & Interactions for HTR6 Gene

genes like me logo Genes that share pathways with HTR6: view

Gene Ontology (GO) - Biological Process for HTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HTR6: view

No data available for SIGNOR curated interactions for HTR6 Gene

Drugs & Compounds for HTR6 Gene

(108) Drugs for HTR6 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist, agonist, Target, antagonist 380
Risperidone Approved, Investigational Pharma Antagonist, antagonist SR-2A inhibitor 477
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Iloperidone Approved Pharma Antagonist, antagonist, Target Dopamine (D2) and serotonin (5HT2) receptor antagonist 0
Asenapine Approved Pharma Antagonist, antagonist, Target Inhibits adrenergic receptor/5-HT receptor 53

(8) Additional Compounds for HTR6 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-HT
Full agonist, Agonist
EMD 386088 hydrochloride
1171123-46-8
EMDT oxalate
263744-72-5
ST 1936 oxalate
1210-81-7
WAY 181187 oxalate

(5) Tocris Compounds for HTR6 Gene

Compound Action Cas Number
EMD 386088 hydrochloride Potent 5-HT6 agonist 1171123-46-8
EMDT oxalate Selective 5-HT6 agonist 263744-72-5
ST 1936 oxalate Selective, high affinity 5-HT6 agonist 1210-81-7
WAY 181187 oxalate High affinity and selective 5-HT6 agonist
WAY 208466 dihydrochloride Selective 5-HT6 agonist 1207064-61-6

(39) ApexBio Compounds for HTR6 Gene

Compound Action Cas Number
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Duloxetine HCl 136434-34-9
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
Lu AE58054 Hydrochloride 5-HT(6)R antagonist 467458-02-2
LY310762 192927-92-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
Naratriptan 143388-64-1
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Pizotifen Malate 5189-11-7
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
SB271046 209481-20-9
SB742457 5-HT6 receptor antagonist,highly selective and high affinity 607742-69-8
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR6: view

Drug Products

Transcripts for HTR6 Gene

mRNA/cDNA for HTR6 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR6 Gene

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR6 Gene

No ASD Table

Relevant External Links for HTR6 Gene

GeneLoc Exon Structure for
HTR6
ECgene alternative splicing isoforms for
HTR6

Expression for HTR6 Gene

mRNA expression in normal human tissues for HTR6 Gene

mRNA differential expression in normal tissues according to GTEx for HTR6 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x11.9), Brain - Putamen (basal ganglia) (x10.9), Brain - Caudate (basal ganglia) (x8.7), and Brain - Cortex (x4.7).

SOURCE GeneReport for Unigene cluster for HTR6 Gene Hs.22180

mRNA Expression by UniProt/SwissProt for HTR6 Gene

P50406-5HT6R_HUMAN
Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus.
genes like me logo Genes that share expression patterns with HTR6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR6 Gene

Orthologs for HTR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR6 35
  • 89.7 (n)
  • 89.77 (a)
HTR6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR6 35
  • 89.19 (n)
  • 89.65 (a)
HTR6 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr6 35
  • 86.45 (n)
  • 87.67 (a)
Htr6 16
Htr6 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR6 35
  • 98.94 (n)
  • 99.32 (a)
HTR6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr6 35
  • 88.32 (n)
  • 92.02 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR6 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR6 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR6 35
  • 69.85 (n)
  • 64.06 (a)
HTR6 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR6 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr6 35
  • 68.41 (n)
  • 66.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC568269 35
  • 65.32 (n)
  • 65.42 (a)
htr6 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6989 37
  • 33 (a)
DopR 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea ser-5 36
  • 22 (a)
ManyToMany
ser-6 36
  • 20 (a)
ManyToMany
Species with no ortholog for HTR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR6 Gene

ENSEMBL:
Gene Tree for HTR6 (if available)
TreeFam:
Gene Tree for HTR6 (if available)

Paralogs for HTR6 Gene

Paralogs for HTR6 Gene

(8) SIMAP similar genes for HTR6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR6: view

Variants for HTR6 Gene

Sequence variations from dbSNP and Humsavar for HTR6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6321 -- 19,679,341(+) CGGCC(A/G)CATCC reference, synonymous-codon
rs6322 -- 19,679,296(+) GCCGC(C/T)GTCAA reference, synonymous-codon
rs1320982 -- 19,677,450(-) AGGAA(A/G)AGGAG intron-variant
rs1883563 -- 19,680,091(+) AGTTA(C/T)TTAAC utr-variant-3-prime
rs1883564 -- 19,680,927(+) CCAGG(C/T)CTGCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR6 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV Insertion 20534489
dgv187n71 CNV Loss 21882294

Variation tolerance for HTR6 Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR6 Gene

Human Gene Mutation Database (HGMD)
HTR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR6 Gene

Disorders for HTR6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HTR6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute stress disorder
  • traumatic stress disorder
amnestic disorder
  • amnesia
schizophrenia
  • schizophrenia 12
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search HTR6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR6

Genetic Association Database (GAD)
HTR6
Human Genome Epidemiology (HuGE) Navigator
HTR6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR6
genes like me logo Genes that share disorders with HTR6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR6 Gene

Publications for HTR6 Gene

  1. Cloning, characterization, and chromosomal localization of a human 5- HT6 serotonin receptor. (PMID: 8522988) Kohen R. … Hamblin M.W. (J. Neurochem. 1996) 2 3 4 25 67
  2. Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved. (PMID: 19506838) MA … Arnt J. (Psychopharmacology (Berl.) 2009) 25 26
  3. Prefrontal executive function and D1, D3, 5-HT2A and 5-HT6 receptor gene variations in healthy adults. (PMID: 18197272) Lane H.Y. … Chang W.H. (J Psychiatry Neurosci 2008) 3 23
  4. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. (PMID: 17848919) Nasrallah H.A. (Mol. Psychiatry 2008) 25 26
  5. Risperidone-related weight gain: genetic and nongenetic predictors. (PMID: 16633140) Lane H.Y. … Chang W.H. (J Clin Psychopharmacol 2006) 3 23

Products for HTR6 Gene

Sources for HTR6 Gene

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