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HTR6 Gene

protein-coding   GIFtS: 67
GCID: GC01P019991

5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 6, G Protein-Coupled1 2     5-HT6R2
Serotonin Receptor 62 3     5-Hydroxytryptamine Receptor 62
5-HT62 3     5-HT-63
5-Hydroxytryptamine (Serotonin) Receptor 61     

External Ids:    HGNC: 53011   Entrez Gene: 33622   Ensembl: ENSG000001587487   OMIM: 6011095   UniProtKB: P504063   

Export aliases for HTR6 gene to outside databases

Previous GC identifers: GC01P019551 GC01P019016 GC01P019137 GC01P019461 GC01P019737 GC01P019864 GC01P018237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR6 Gene:
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins.
The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic
AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the
brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. (provided by
RefSeq, Aug 2013)

GeneCards Summary for HTR6 Gene:
HTR6 (5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled) is a protein-coding gene. Diseases associated with HTR6 include mood disorder, and tardive dyskinesia. GO annotations related to this gene include serotonin receptor activity and histamine receptor activity. An important paralog of this gene is TAAR6.

UniProtKB/Swiss-Prot: 5HT6R_HUMAN, P50406
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs

summary for HTR6 Gene:
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and
hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic
neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has
been localized to chromosome 1 (1p35-36).

Gene Wiki entry for HTR6 (5-HT6 receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR6 gene promoter:
         CREB   deltaCREB   NF-kappaB   NF-kappaB1   NF-AT1   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR6 promoter sequence
   Search Chromatin IP Primers for HTR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36-p35   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36-p35

HTR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019991:  view genomic region     (about GC identifiers)

Start:
19,991,780 bp from pter      End:
20,006,055 bp from pter
Size:
14,276 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT6R_HUMAN, P50406 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 6  
Size: 440 amino acids; 46954 Da
Secondary accessions: Q13640 Q5TGZ1

Explore the universe of human proteins at neXtProt for HTR6: NX_P50406

Explore proteomics data for HTR6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HTR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000862.1  
    ENSEMBL proteins: 
     ENSP00000289753  
    Reactome Protein details: P50406

    HTR6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT6 receptor
    5-Hydroxytryptamine receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002232 5HT6_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P50406

    ProtoNet protein and cluster: P50406

    1 Blocks protein domain: IPB002232 5-hydroxytryptamine 6 receptor signature

    UniProtKB/Swiss-Prot: 5HT6R_HUMAN, P50406
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT6R_HUMAN, P50406
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs

         Genatlas biochemistry entry for HTR6:
    5-hydroxytrhyptamine (serotonin) receptor,subtype 6,prominently expressed in the caudal nucleus,G protein coupled
    receptor superfamily,activating adenylate cyclase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004969histamine receptor activity TAS8522988
    GO:0004993serotonin receptor activity IEA--
    GO:0005515protein binding IPI17189269
         
    HTR6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Htr6):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism 

    HTR6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR6: Htr6tm1Lex Htr6tm1Tct

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR6

    miRNA
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    Block miRNA regulation of human, mouse, rat HTR6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HTR6:
    hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidHTR6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTR6
    Predesigned siRNA for gene silencing in human, mouse, rat HTR6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HTR6 (NM_000871)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT6R_HUMAN, P50406: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8522988
    GO:0005929cilium IEA--
    GO:0016021integral component of membrane ----
    GO:0030425dendrite IEA--

    HTR6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR6 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Transcription CREB pathway
    Development Ligand independent activation of ESR1 and ESR20.34
    Transcription CREB pathway0.34
    5CREB Pathway
    Intracellular Calcium Signaling0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR6
        Intracellular Calcium Signaling

    2 GeneGo (Thomson Reuters) Pathways for HTR6
        Development Ligand-independent activation of ESR1 and ESR2
    Transcription CREB pathway

    3 BioSystems Pathways for HTR6
        Serotonin Receptor 4/6/7 and NR3C Signaling
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR6
        Serotonin receptors
    G alpha (s) signalling events

    1 PharmGKB Pathway for HTR6
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for HTR6):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR6 (P504061, 2, 3 ENSP000002897534) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062411, 2, 3, ENSP000003576564EBI-1182222,EBI-515315 MINT-7214635 MINT-7214669 MINT-7214596 MINT-7214580 MINT-7214683 MINT-7214655 I2D: score=5 STRING: ENSP00000357656
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    GNASQ5JWF23, ENSP000003601414I2D: score=2 STRING: ENSP00000360141
    COPS5Q929053I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA--
    GO:0007210serotonin receptor signaling pathway ----
    GO:0007268synaptic transmission TAS8522988
    GO:0007420brain development IEA--

    HTR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HTR6
      Browse compounds at ApexBio 

    Compounds for HTR6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WAY 208466 dihydrochlorideSelective 5-HT6 agonist[633304-27-5]
    SB 271046 hydrochloride Orally active, selective 5-HT6 antagonist [209481-20-9]
    SB 399885 hydrochloridePotent and selective 5-HT6 antagonist[402713-80-8]
    SB 258585 hydrochloride Potent, selective 5-HT6 antagonist [209480-63-7]
    Ro 04-6790Potent and selective 5-HT6 antagonist[202466-68-0]

    1 HMDB Compound for HTR6    About this table
    CompoundSynonyms CAS #PubMed Ids
    OndansetronOndansetron (see all 4)99614-02-5--

    9 DrugBank Compounds for HTR6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dimethyltryptamine-- 61-50-7target--17239595 10715164 278843 270770
    Asenapine-- 65576-45-6targetantagonist21655346 18308814 10592235
    SertindoleSertindol [inn-spanish] (see all 2)106516-24-9targetantagonist11888555 19506838
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist17848919
    Clozapine-- 5786-21-0targetantagonist17848919
    Iloperidone-- 133454-47-4targetantagonist23272794
    Olanzapine-- 132539-06-1targetantagonist17848919
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7targetother/unknown17848919
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist17848919

    Selected IUPHAR Ligands for HTR6 (5-HT6 receptor) (see all 52)    About this table
    LigandTypeActionAffinityPubmed IDs
    methiothepin
    AntagonistAntagonist8.2 - 9.48522988 9730917 9284367
    SB399885
    AntagonistAntagonist917069795
    [125I]SB258585
    AntagonistAntagonist917069795
    SB 271046
    AntagonistAntagonist8.99925723
    E-6801
    AgonistPartial agonist8.715771424
    [3H]LSD
    AgonistFull agonist8.79284367
    WAY-181187
    AgonistAgonist8.717625499
    ergotamine
    AgonistFull agonist8 - 8.69284367 9730917
    SB357134
    AntagonistAntagonist8.511140733
    LSD
    AgonistFull agonist8.49730917

    9 Novoseek inferred chemical compound relationships for HTR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iloperidone 78.3 2 8997630 (1), 12818723 (1)
    5-carboxamidotryptamine 66.1 1 8692281 (1)
    5-hydroxytryptamine 64.6 5 8883928 (1), 15531082 (1), 12579508 (1), 8692281 (1)
    risperidone 50.4 2 16633140 (1), 14741325 (1)
    clozapine 46.4 8 11163544 (3), 10363930 (2), 7583621 (1), 7961573 (1)
    dopamine 36.4 14 7583621 (1), 12579508 (1), 19426122 (1), 18663573 (1) (see all 5)
    norepinephrine 25.3 1 12222764 (1)
    gaba 13.4 1 16489368 (1)
    nmda 7.68 3 16489368 (1), 17328523 (1)



    HTR6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR6 gene: 
    NM_000871.2  

    Unigene Cluster for HTR6:

    5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
    Hs.22180  [show with all ESTs]
    Unigene Representative Sequence: NM_000871
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000289753(uc001bcl.3)
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HTR6 (NM_000871)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR6
    Primer
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    OriGene qPCR primer pairs and template standards for HTR6
    OriGene qSTAR qPCR primer pairs in human, mouse for HTR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTR6
      QuantiTect SYBR Green Assays in human, mouse, rat HTR6
      QuantiFast Probe-based Assays in human, mouse, rat HTR6

    Additional mRNA sequence: 

    AF007141.1 AY429105.1 BC074995.2 BC074996.2 L41147.1 Z49119.1 

    1 DOTS entry:

    DT.408450 

    16 AceView cDNA sequences:

    BC074995 Z39184 L41147 NM_000871 AY429105 BC074996 AW298369 AF007141 
    AW290937 BF446062 Z49119 Z43093 BF115644 T77209 R17302 R54296 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCCTGG
    HTR6 Expression
    About this image


    HTR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Substantia Nigra   
    HTR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22180

    UniProtKB/Swiss-Prot: 5HT6R_HUMAN, P50406
    Tissue specificity: Expressed in several human brain regions, most prominently in the caudate nucleus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR6: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HTR6
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    QuantiFast Probe-based Assays in human, mouse, rat HTR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr61 , 5 5-hydroxytryptamine (serotonin) receptor 61, 5 86.45(n)1
    87.67(a)1
      4 (70.57 cM)5
    155651  NM_021358.21  NP_067333.11 
     1390611085 
    chicken
    (Gallus gallus)
    Aves HTR61 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 69.85(n)
    64.06(a)
      430019  NM_001173440.1  NP_001166911.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR66
    5-hydroxytryptamine (serotonin) receptor 6, G prot...
    53(a)
    1 ↔ 1
    GL344078.1(15346-21021)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr61 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 68.41(n)
    66.33(a)
      100493899  XM_002941959.2  XP_002942005.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5682691 5-hydroxytryptamine receptor 6-like 65.32(n)
    65.42(a)
      568269  XM_691589.5  XP_696681.5 
    worm
    (Caenorhabditis elegans)
    Secernentea ser-56
    ser-66
    Protein SER-6 (ser-6) mRNA, complete cds
    22(a)
    20(a)
    many ↔ many
    many ↔ many
    I(8384980-8386978) WBGene00008890
    IV(2960123-2964395) WBGene00021897


    ENSEMBL Gene Tree for HTR6 (if available)
    TreeFam Gene Tree for HTR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR6 gene
    TAAR62  TAAR22  ADRB12  TAAR92  TAAR82  HRH22  DRD12  TAAR12  
    ADRB22  HTR42  ADRB32  DRD52  TAAR52  
    8 SIMAP similar genes for HTR6 using alignment to 1 protein entry:     5HT6R_HUMAN:
    HTR2A    HTR4B    HTR4    ADRA1A    HRH2    ADRB3
    ADRA1B    ADRB1

    HTR6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR6 (see all 467)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125622391,2
    C,F,H--20200050(+) ACTTGC/GTGCTG 1 -- us2k14Minor allele frequency- G:0.08NA WA EA 244
    rs1900519931,2
    --20200115(+) TCAGCA/GTTATT 1 -- us2k10--------
    rs1929194471,2
    --20200194(+) GCCTTC/TGATTT 1 -- us2k10--------
    rs125690861,2
    C,F,H--20200195(+) CCTTCG/AATTTG 1 -- us2k110Minor allele frequency- A:0.11NA EA WA 636
    rs1461021561,2
    --20200248(+) ACCCCA/GTTCTC 1 -- us2k10--------
    rs1448241921,2
    C--20200284(+) TTCTC-/TTCT  
            
    TTCTT
    1 -- us2k10--------
    rs592111811,2
    C--20200355(+) TTTTT-/T/TT  
      T
    /TTTT
    GACAG
    2 -- us2k1 cds11NA 2
    rs67038421,2
    C--20200441(+) caagcG/Aattct 1 -- us2k17Minor allele frequency- A:0.08NA WA CSA 12
    rs559738321,2
    C,F--20200604(+) AAGTGA/CTGGGA 1 -- us2k13Minor allele frequency- C:0.33NA WA CSA 6
    rs1154606971,2
    C,F--20200644(+) ACTTTC/TTCTGT 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for HTR6 (19991780 - 20006055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HTR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508991CNV Insertion20534489
    dgv187n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HTR6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR6
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601109    OMIM disorders: --

    15 diseases for HTR6:    
    About MalaCards
    mood disorder    tardive dyskinesia    chronic fatigue syndrome    major depressive disorder
    headache    attention deficit hyperactivity disorder    anorexia nervosa    schizophrenia
    alzheimer's disease    migraine    bipolar disorder    parkinson's disease
    obesity    neuronitis    cerebritis


    HTR6 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HTR6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 48.3 20 11287786 (5), 10477121 (3), 15048641 (2), 12579508 (1) (see all 6)
    alzheimers disease 25.1 6 15531082 (2), 11725820 (2), 12618306 (1), 19589055 (1)
    mood disorders 22.4 2 10581475 (1)
    bipolar disorder 10.2 1 10893499 (1)

    Genetic Association Database (GAD): HTR6
    Human Genome Epidemiology (HuGE) Navigator: HTR6 (41 documents)

    Export disorders for HTR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR6 gene, integrated from 10 sources (see all 139):
    (articles sorted by number of sources associating them with HTR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, and chromosomal localization of a human 5- HT6 serotonin receptor. (PubMed id 8522988)1, 2, 3 Kohen R.... Hamblin M.W. (J. Neurochem. 1996)
    2. Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function. (PubMed id 11287786)1, 4, 9 Chiu H.J....Liu W.C. (Neuropsychobiology 2001)
    3. No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population. (PubMed id 16682118)1, 4, 9 Tochigi M....Sasaki T. (Neurosci. Lett. 2006)
    4. Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese. (PubMed id 15531082)1, 4, 9 Kan R....Wang L. (Neurosci. Lett. 2004)
    5. Lack of association between the T--&gt;C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PubMed id 11163544)1, 4, 9 Masellis M....Kennedy J.L. (Schizophr. Res. 2001)
    6. 5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country. (PubMed id 12618306)1, 4, 9 Alvarez-Alvarez M....de Pancorbo M.M. (Neurosci. Lett. 2003)
    7. Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease. (PubMed id 11725820)1, 4, 9 Thome J....RAPsler M. (J Neural Transm 2001)
    8. [Associations between six functional genes and schizophrenia]. (PubMed id 12579508)1, 4, 9 Zhang M.L....Jiang S.D. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    9. Risperidone-related weight gain: genetic and nongenetic predictors. (PubMed id 16633140)1, 4, 9 Lane H.Y....Chang W.H. (J Clin Psychopharmacol 2006)
    10. Serotonergic genes and personality traits in the Korean population. (PubMed id 14698468)1, 4, 9 Ham B.J....Lee M.S. (Neurosci. Lett. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3362 HGNC: 5301 AceView: HTR6 Ensembl:ENSG00000158748 euGenes: HUgn3362
    ECgene: HTR6 Kegg: 3362 H-InvDB: HTR6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR6 gene:
    Search GeneIP for patents involving HTR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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