HTR5A Gene
protein-coding GIFtS: 62
GCID: GC07P154862
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5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled(Previous name: 5-hydroxytryptamine (serotonin) receptor 5A )
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Aliases
for HTR5A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled1 2 | | 5-HT-5A2 3 | | 5-HT5A1 2 3 | | 5-Hydroxytryptamine (Serotonin) Receptor 5A1 | | Serotonin Receptor 5A2 3 | | 5-Hydroxytryptamine Receptor 5A2 | | 5-HT-52 3 | | |
Export aliases for HTR5A gene to outside databasesPrevious GC identifers: GC07P153085 GC07P154176 GC07P154253 GC07P154299 GC07P154492 GC07P148594 |
Summaries
for HTR5A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HTR5A:
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatricconditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptorfor 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through theregulation of intracellular Ca2+ mobilization. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins
 summary
for HTR5A: Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP
formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been
found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans
Gene Wiki entry for HTR5A (5-HT5A receptor)
|
Genomic Views
for HTR5A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007741.14 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HTR5A gene promoter:
NRSF form 1 IRF-7A Pax-4a NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR5A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR5A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.2 HGNC cytogenetic band: 7q36.1HTR5A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P154862: view genomic region
(about GC identifiers)
Start:
|
154,862,034 bp from pter |
End:
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154,877,459 bp from pter |
Size:
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15,426 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 154,090,870-154,105,804 |
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Proteins
for HTR5A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 5A Size: 357 amino acids; 40255 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M2D2Explore the universe of human proteins at neXtProt for HTR5A: NX_P47898
HTR5A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076917.1
ENSEMBL proteins: ENSP00000287907 Reactome Protein details: P47898
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
HTR5A for ontologies About GeneDecksing
HTR5A Antibody Products:
Assay Products for HTR5A: |
Protein
Domains /
Families
for HTR5A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR5A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47898ProtoNet protein and cluster: P47898 2 Blocks protein families: IPB001397 5-hydroxytryptamine 5A receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HTR5A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins Genatlas biochemistry entry for HTR5A:5-hydroxytryptamine (serotonin) receptor,subtype 5A,G protein coupled receptor superfamily,unlikely to be associatedwith autistic disorder
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR5A
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR5A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004993 | serotonin receptor activity |
IDA | 7988681 |
HTR5A for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HTR5A:
Animal Models:
Mouse knock-out Htr5atm1Rhn for HTR5A
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Htr5a):
HTR5A for phenotypes About GeneDecksing
|
Pathways & Interactions
for HTR5A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Monoamine GPCRs | | | 4 | Calcium signaling pathway | | | 5 | CREB Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR5A
2  BioSystems Pathways for HTR5A
5/8 
Reactome Pathways for HTR5A (see all 8)
2 
Kegg Pathways (Kegg details for HTR5A):
HTR5A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR5A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/145 Interacting proteins for HTR5A (ENSP000002879074) via UniProtKB, MINT, STRING, and/or I2D (see all 145)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 7988681 | | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
IEA | -- | | GO:0007210 | serotonin receptor signaling pathway |
IDA | 7988681 | | GO:0007420 | brain development |
-- | -- | | GO:0019933 | cAMP-mediated signaling |
IEA | -- |
HTR5A for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR5A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for HTR5A available from Tocris Bioscience About this table
1 HMDB Compound for HTR5A About this table
Search CenterWatch for drugs/clinical trials and news about HTR5A / 5HT5A
|
Transcripts
for HTR5A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HTR5A gene: NM_024012.3 Unigene Cluster for HTR5A: 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Hs.744621 [show with all ESTs]Unigene Representative Sequence: NM_0240122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000287907(uc003wlu.1) ENST00000486819
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR5A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR5A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HTR5A (NM_024012) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR5A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR5A |
Additional cDNA sequence: AF498985.1 AK094255.1 AK310284.1 BC112021.1 BC113468.1 2 DOTS entries: DT.91692424 DT.95257126 14 AceView cDNA sequences: BX538209 BX280849 AF498985 BM805859 Z43601 BI489745 CK003801 Z39664 AK094255 CD631835 NM_024012 CD631831 CD631833 R14905
GeneLoc Exon Structure
|
Expression
for HTR5A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAACCAGT
About this image
See HTR5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR5A
SOURCE GeneReport for Unigene cluster: Hs.744621
SABiosciences Expression via Pathway-Focused PCR Array including HTR5A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR5A
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR5A |
Orthologs
for HTR5A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR5A gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for HTR5A (if available)
TreeFam Gene Tree for HTR5A (if available) |
Paralogs
for HTR5A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HTR5A gene
- DRD42 HTR1A2 ADRA1B2 DRD22 HTR1F2 HTR72 ADRA2C2 ADRA2A2
- HTR1D2 ADRA1A2 ADRA2B2 HTR1E2 DRD32 HTR1B2 ADRA1D2
18/38 SIMAP similar genes for HTR5A using alignment to 5 protein entries: 5HT5A_HUMAN (see all proteins)
(see all similar genes):HTR2B LPAR1 HTR7 alpha 1c-adrenoceptor subtype TAAR2 HTR1F
ADORA2A ADRA1B HTR1D HTR2A OPRK1 ADRA1D
HTR1E DRD1 ADRA1A HTR1B TACR3 ADRB3
HTR5A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HTR5A
PGOHUM00000240882
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Genomic Variants
for HTR5A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HTR5A (154862034 - 154877459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HTR5A
2 CNVs: 32968 62748
1 Indel: 12977
Human Gene Mutation Database (HGMD): HTR5A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR5A |
|
Disorders
/ Diseases
for HTR5A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR5A for disorders About GeneDecksing
OMIM gene information: 601305
OMIM disorders: --
13  diseases for HTR5A: About MalaCardsattention deficit hyperactivity disorder chronic fatigue syndrome anorexia nervosa seckel syndrome
autistic disorder alcohol dependence mood disorder holoprosencephaly
hermaphroditism alcoholism pharyngitis schizophrenia
neuronitis
1 disease from the University of Copenhagen DISEASES database for HTR5A:Holoprosencephaly Genetic Association Database (GAD): HTR5A
Human Genome Epidemiology (HuGE) Navigator: HTR5A (15 documents)
Export disorders for HTR5A gene to outside databases
|
Publications
for HTR5A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HTR5A gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with HTR5A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterisation of the human 5-HT5A serotonin receptor. (PubMed id 7988681)1, 2, 3 Rees S....Lee M. (1994)
- [Alcohol dependence and polymorphisms of serotonin-related genes] (PubMed id 15581469)1, 4, 9 Gorwood P....Hamon M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)1, 4 Turecki G....Rouleau G.A. (2003)
- Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. (PubMed id 11317225)1, 4 Iwata N....Goldman D. (2001)
- Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. (PubMed id 12558985)1, 9 Noda M....Wada K. (2003)
- Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. (PubMed id 12930153)1, 9 Khorana N....Glennon R.A. (2003)
- Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. (PubMed id 11343685)1, 9 Grailhe R....Hen R. (2001)
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
- Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1 Corominas R....Cormand B. (2010)
|
External Searches for HTR5A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HTR5A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTR5A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR5A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HTR5A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HTR5A gene:
Search GeneIP for patents involving HTR5A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HTR5A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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