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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR5A Gene

protein-coding   GIFtS: 62
GCID: GC07P154862

5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 5A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled1 2     5-HT5A2 3
Serotonin Receptor 5A2 3     5-Hydroxytryptamine (Serotonin) Receptor 5A1
5-HT-52 3     5-Hydroxytryptamine Receptor 5A2
5-HT-5A2 3     

External Ids:    HGNC: 53001   Entrez Gene: 33612   Ensembl: ENSG000001572197   OMIM: 6013055   UniProtKB: P478983   

Export aliases for HTR5A gene to outside databases

Previous GC identifers: GC07P153085 GC07P154176 GC07P154253 GC07P154299 GC07P154492 GC07P148594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR5A Gene:
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric
conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member
of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a
receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part
through the regulation of intracellular Ca2+ mobilization. (provided by RefSeq, Jul 2008)

GeneCards Summary for HTR5A Gene: 
HTR5A (5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR5A include autistic disorder, and seckel syndrome, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins

summary for HTR5A Gene:
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP
formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been
found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans

Gene Wiki entry for HTR5A (5-HT5A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007741.14  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR5A gene promoter:
         NRSF form 1   IRF-7A   Pax-4a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HTR5A promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.2   HGNC cytogenetic band: 7q36.1

HTR5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR5A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P154862:  view genomic region     (about GC identifiers)

Start:
154,862,034 bp from pter      End:
154,877,459 bp from pter
Size:
15,426 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 154,090,870-154,105,804     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 5A  
Size: 357 amino acids; 40255 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q2M2D2

Explore the universe of human proteins at neXtProt for HTR5A: NX_P47898

Explore proteomics data for HTR5A at MOPED 

HTR5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

HTR5A Protein Expression

REFSEQ proteins: NP_076917.1  
ENSEMBL proteins: 
 ENSP00000287907  
Reactome Protein details: P47898
Human Recombinant Protein Products for HTR5A: 
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Cloud-Clone Corp. Proteins for HTR5A 

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005791rough endoplasmic reticulum IEA--
GO:0005794Golgi apparatus IEA--
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane IEA--
GO:0016021integral to membrane ----

HTR5A for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
HTR: 5-HT (serotonin) receptors
HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

IUPHAR Guide to PHARMACOLOGY protein family classification: 5-ht5a receptor 
5-Hydroxytryptamine receptors

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR001397 5HT5A_rcpt
 IPR002231 5HT_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P47898

ProtoNet protein and cluster: P47898

2 Blocks protein domains:
IPB001397 5-hydroxytryptamine 5A receptor signature
IPB002231 5-hydroxytryptamine receptor signature


UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898
Similarity: Belongs to the G-protein coupled receptor 1 family


HTR5A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: 5HT5A_HUMAN, P47898
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins

     Genatlas biochemistry entry for HTR5A:
5-hydroxytryptamine (serotonin) receptor,subtype 5A,G protein coupled receptor superfamily,unlikely to be
associated with autistic disorder

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity ----
GO:0004993serotonin receptor activity IDA7988681
     
HTR5A for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for HTR5A:
 Synthetic lethal with c-Myc af 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Htr5a):
 behavior/neurological  normal 

HTR5A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Htr5atm1Rhn for HTR5A

   inGenious Targeting Laboratory - Custom generated mouse model solutions for HTR5A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTR5A

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miRNA
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2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR5A:
hsa-miR-433 hsa-miR-586
SwitchGear 3'UTR luciferase reporter plasmidHTR5A 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR5A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HTR5A About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
G alpha (i) signalling events0.46
2Monoamine GPCRs
Monoamine GPCRs0.79
Serotonin receptors0.36
Amine ligand-binding receptors0.79
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
4CREB Pathway
Intracellular Calcium Signaling0.50
5Circadian entrainment
Serotonergic synapse0.33

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR5A
    Intracellular Calcium Signaling

2 BioSystems Pathways for HTR5A
    GPCRs, Class A Rhodopsin-like
Monoamine GPCRs

5/8        Reactome Pathways for HTR5A (see all 8)
    GPCR downstream signaling
Signaling by GPCR
GPCR ligand binding
Class A/1 (Rhodopsin-like receptors)
Serotonin receptors


3         Kegg Pathways  (Kegg details for HTR5A):
    Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse


HTR5A for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR5A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/145 Interacting proteins for HTR5A (ENSP000002879074) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
InteractantInteraction Details
GeneCardExternal ID(s)
ADCY2ENSP000003429524STRING: ENSP00000342952
ADRA2AENSP000002801554STRING: ENSP00000280155
ADRA2BENSP000003872814STRING: ENSP00000387281
ADRA2CENSP000003860694STRING: ENSP00000386069
AGTR2ENSP000003609734STRING: ENSP00000360973
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway TAS7988681
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA--
GO:0007210serotonin receptor signaling pathway IDA7988681
GO:0007420brain development ----
GO:0007610behavior ----

HTR5A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for HTR5A available from Tocris Bioscience    About this table
CompoundAction CAS #
SB 699551Selective 5-ht5a antagonist[791789-61-2]

1 HMDB Compound for HTR5A    About this table
CompoundSynonyms CAS #PubMed Ids
Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

10/20 IUPHAR Ligands for HTR5A (5-ht5a receptor) (see all 20)    About this table 
LigandTypeActionAffinityPubmed IDs
[125I]LSD
AgonistFull agonist9.711343685
methiothepin
AntagonistAntagonist8.5 - 8.97988681 11343685
ergotamine
AntagonistAntagonist8 - 8.77988681 11343685
[3H]5-CT
AgonistFull agonist8.611343685
SB 699551
AntagonistAntagonist8.216002289
5-CT
AgonistFull agonist7.6 - 7.77988681 11343685
ritanserin
AntagonistAntagonist7.611343685
methysergide
AntagonistAntagonist77988681
5-HT
AgonistFull agonist6.7 - 6.97988681 11343685
clozapine
AntagonistAntagonist6 - 6.57988681 11343685

Search CenterWatch for drugs/clinical trials and news about HTR5A / 5HT5A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HTR5A gene: 
NM_024012.3  

Unigene Cluster for HTR5A:

5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
Hs.744621  [show with all ESTs]
Unigene Representative Sequence: NM_024012
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000287907(uc003wlu.1) ENST00000486819
miRNA
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hsa-miR-433 hsa-miR-586
SwitchGear 3'UTR luciferase reporter plasmidHTR5A 3' UTR sequence
Inhib. RNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR5A

Additional mRNA sequence: 

AF498985.1 AK094255.1 AK310284.1 BC112021.1 BC113468.1 

2 DOTS entries:

DT.91692424  DT.95257126 

14 AceView cDNA sequences:

BX280849 BX538209 AF498985 Z39664 CK003801 Z43601 AK094255 NM_024012 
BI489745 CD631835 BM805859 CD631831 CD631833 R14905 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HTR5A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAAACCAGT
HTR5A Expression
About this image


See HTR5A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR5A

SOURCE GeneReport for Unigene cluster: Hs.744621
    SABiosciences Expression via Pathway-Focused PCR Array including HTR5A: 
          G Protein Coupled Receptors 384HT in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR5A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR5A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HTR5A gene from 6/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Htr5a1 , 5 5-hydroxytryptamine (serotonin) receptor 5A1, 5 84.27(n)1
88.2(a)1
  5 (13.24 cM)5
155631  NM_008314.21  NP_032340.21 
 278419475 
chicken
(Gallus gallus)
Aves HTR5A1 5-hydroxytryptamine (serotonin) receptor 5A 77.56(n)
80(a)
  428409  XM_425970.1  XP_425970.1 
lizard
(Anolis carolinensis)
Reptilia HTR5A6
Uncharacterized protein
79(a)
1 ↔ 1
6(5482249-5492133)
zebrafish
(Danio rerio)
Actinopterygii htr5al1 5-hydroxytryptamine (serotonin) receptor 5A like 76.38(n)
82.45(a)
  368475  NM_001007121.2  NP_001007122.1 
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A3 serotonin receptor signaling pathway
G-protein more
46(a)
(best of 3)
    --
worm
(Caenorhabditis elegans)
Secernentea tyra-21 Protein TYRA-2 46.27(n)
36.65(a)
  180970  NM_001038448.1  NP_001033537.1 


ENSEMBL Gene Tree for HTR5A (if available)
TreeFam Gene Tree for HTR5A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HTR5A gene
HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  
HTR2C2  ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR1B2  
18/36 SIMAP similar genes for HTR5A using alignment to 5 protein entries:     5HT5A_HUMAN (see all proteins) (see all similar genes):
HTR2B    LPAR1    HTR7    alpha 1c-adrenoceptor subtype    TAAR2    HTR1F
ADORA2A    ADRA1B    HTR1D    HTR2A    OPRK1    ADRA1D
HTR1E    DRD1    ADRA1A    HTR1B    TACR3    ADRB3

HTR5A for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for HTR5A
PGOHUM00000240882


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/486 SNPs in HTR5A are shown (see all 486)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0357534
A colorectal cancer sample4--see VAR_0357532 R C mis40--------
rs1856282401,2
--154865273(+) TTCCAC/TGTGTA 1 -- int10--------
rs22181871,2
C,F,H--154865283(-) TGGACG/CCTCAT 1 -- int126Minor allele frequency- C:0.14NS EA NA WA CSA 2284
rs13718211,2
C,F,H--154865301(-) CCTGGC/TCTGGA 1 -- int126Minor allele frequency- T:0.21MN NS EA NA CSA WA 2264
rs18220871,2
C,F,A,H--154865454(-) TTTTAT/CAGGAA 1 -- int121Minor allele frequency- C:0.16MN NS EA NA CSA WA 1724
rs602828431,2
C--154865543(+) ACACACACA/-  
        
TATAT
1 -- int11Minor allele frequency- -:0.00NA 2
rs1124599261,2
C--154865552(+) ACACAC/TATATA 1 -- int10--------
rs1126541571,2
C--154865554(+) ACATAC/TATATA 1 -- int10--------
rs2001159791,2
C--154865560(+) ATATAC/TATATG 1 -- int10--------
rs77828281,2
A--154865575(+) tgtgtA/Gtatat 1 -- int10--------

HapMap Linkage Disequilibrium report for HTR5A (154862034 - 154877459 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for HTR5A:    About this table     
Variant IDTypeSubtypePubMed ID
esv2735525CNV Deletion23290073
nsv821049CNV Duplication20802225
nsv513740CNV Insertion21212237
nsv824406CNV Loss20364138
nsv512006CNV Loss21212237
nsv824407CNV Loss20364138
esv9298CNV Loss19470904
nsv8239CNV Loss18304495
nsv366608CNV Loss16902084


Human Gene Mutation Database (HGMD): HTR5A
SABiosciences Cancer Mutation PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for HTR5A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 601305    OMIM disorders: --

10 diseases for HTR5A:    About MalaCards
autistic disorder    seckel syndrome    chronic fatigue syndrome    holoprosencephaly
attention deficit hyperactivity disorder    mood disorder    alcohol dependence    anorexia nervosa
alcoholism    schizophrenia

1 disease from the University of Copenhagen DISEASES database for HTR5A:
Holoprosencephaly

HTR5A for disorders           About GeneDecksing

Genetic Association Database (GAD): HTR5A
Human Genome Epidemiology (HuGE) Navigator: HTR5A (15 documents)

Export disorders for HTR5A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HTR5A gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with HTR5A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and characterisation of the human 5-HT5A serotonin receptor. (PubMed id 7988681)1, 2, 3 Rees S....Lee M. (1994)
  2. [Alcohol dependence and polymorphisms of serotonin-related genes] (PubMed id 15581469)1, 4, 9 Gorwood P....Hamon M. (2004)
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
  4. Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (2010)
  5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
  6. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (2009)
  7. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
  8. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. (PubMed id 19381154)1, 4 Brezo J....Turecki G. (2009)
  9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
  10. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. (PubMed id 18079067)1, 4 Smith A.K....Rajeevan M.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3361 HGNC: 5300 AceView: HTR5A Ensembl:ENSG00000157219 euGenes: HUgn3361
ECgene: HTR5A Kegg: 3361 H-InvDB: HTR5A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HTR5A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HTR5A gene:
Search GeneIP for patents involving HTR5A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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