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HTR5A Gene

protein-coding   GIFtS: 59
GCID: GC07P154862

5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 5A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled1 2     5-HT5A2 3
Serotonin Receptor 5A2 3     5-Hydroxytryptamine (Serotonin) Receptor 5A1
5-HT-52 3     5-Hydroxytryptamine Receptor 5A2
5-HT-5A2 3     

External Ids:    HGNC: 53001   Entrez Gene: 33612   Ensembl: ENSG000001572197   OMIM: 6013055   UniProtKB: P478983   

Export aliases for HTR5A gene to outside databases

Previous GC identifers: GC07P153085 GC07P154176 GC07P154253 GC07P154299 GC07P154492 GC07P148594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR5A Gene:
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric
conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member
of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a
receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part
through the regulation of intracellular Ca2+ mobilization. (provided by RefSeq, Jul 2008)

GeneCards Summary for HTR5A Gene:
HTR5A (5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR5A include autistic disorder, and seckel syndrome. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins

summary for HTR5A Gene:
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP
formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been
found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans

Gene Wiki entry for HTR5A (5-HT5A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HTR5A gene promoter:
         NRSF form 1   IRF-7A   Pax-4a   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HTR5A promoter sequence
   Search Chromatin IP Primers for HTR5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.2   HGNC cytogenetic band: 7q36.1

HTR5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR5A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P154862:  view genomic region     (about GC identifiers)

Start:
154,862,034 bp from pter      End:
154,877,459 bp from pter
Size:
15,426 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 154,090,870-154,105,804     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 5A  
Size: 357 amino acids; 40255 Da
Secondary accessions: Q2M2D2

Explore the universe of human proteins at neXtProt for HTR5A: NX_P47898

Explore proteomics data for HTR5A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6, Asn21

  • See HTR5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076917.1  
    ENSEMBL proteins: 
     ENSP00000287907  
    Reactome Protein details: P47898

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-ht5a receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001397 5HT5A_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47898

    ProtoNet protein and cluster: P47898

    2 Blocks protein domains:
    IPB001397 5-hydroxytryptamine 5A receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT5A_HUMAN, P47898
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT5A_HUMAN, P47898
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins

         Genatlas biochemistry entry for HTR5A:
    5-hydroxytryptamine (serotonin) receptor,subtype 5A,G protein coupled receptor superfamily,unlikely to be
    associated with autistic disorder

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA7988681
         
    HTR5A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR5A:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Htr5a):
     behavior/neurological  normal 

    HTR5A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr5atm1Rhn for HTR5A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR5A
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    2 qRT-PCR Assays for microRNAs that regulate HTR5A:
    hsa-miR-433 hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidHTR5A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT5A_HUMAN, P47898: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    golgi apparatus2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    HTR5A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR5A About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR5A
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR5A
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR5A
        Serotonin receptors
    G alpha (i) signalling events


    3 Kegg Pathways  (Kegg details for HTR5A):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR5A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HTR5A: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR5A (ENSP000002879074) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS7988681
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA--
    GO:0007210serotonin receptor signaling pathway IDA7988681
    GO:0007420brain development ----
    GO:0019933cAMP-mediated signaling IEA--

    HTR5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    7 ApexBio Compounds for HTR5A     About this table
    CompoundAction CAS #
    Adoprazine5-HT1A receptor agonist properties[222551-17-9]
    Granisetron HCl5-HT3 receptor antagonist[107007-99-8]
    SB 271046 hydrochloridepotent, selective and orally active 5-HT6 receptor antagonist[209481-24-3]
    SEA0400specific Na+/Ca2+ exchange (NCX) inhibitor[223104-29-8]
    Vilazodonecombined SSRI and 5-HT1A receptor partial agonist[163521-12-8]
    Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor[508233-74-7]
    WAY-100635 maleate saltpotent and selective 5-hydroxytryptamine1A antagonist[634908-75-1]

    Compounds for HTR5A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 699551Selective 5-ht5a antagonist[791789-61-2]

    1 HMDB Compound for HTR5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    Selected IUPHAR Ligands for HTR5A (5-ht5a receptor) (see all 20)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]LSD
    AgonistFull agonist9.711343685
    methiothepin
    AntagonistAntagonist8.5 - 8.97988681 11343685
    ergotamine
    AntagonistAntagonist8 - 8.77988681 11343685
    [3H]5-CT
    AgonistFull agonist8.611343685
    SB 699551
    AntagonistAntagonist8.216002289
    5-CT
    AgonistFull agonist7.6 - 7.77988681 11343685
    ritanserin
    AntagonistAntagonist7.611343685
    methysergide
    AntagonistAntagonist77988681
    5-HT
    AgonistFull agonist6.7 - 6.97988681 11343685
    clozapine
    AntagonistAntagonist6 - 6.57988681 11343685



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR5A gene: 
    NM_024012.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287907(uc003wlu.1) ENST00000486819
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HTR5A
      QuantiFast Probe-based Assays in human, mouse, rat HTR5A

    14 AceView cDNA sequences:

    BX280849 BX538209 AF498985 CD631835 Z39664 BI489745 Z43601 AK094255 
    CK003801 NM_024012 BM805859 CD631831 CD631833 R14905 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAACCAGT
    HTR5A Expression
    About this image

    HTR5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR5A Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including HTR5A: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HTR5A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr5a1 , 5 5-hydroxytryptamine (serotonin) receptor 5A1, 5 84.22(n)1
    87.96(a)1
      5 (13.24 cM)5
    155631  NM_008314.21  NP_032340.21 
     278419475 
    chicken
    (Gallus gallus)
    Aves HTR5A1 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 77.56(n)
    80(a)
      428409  XM_425970.2  XP_425970.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR5A6
    5-hydroxytryptamine (serotonin) receptor 5A, G pro...
    79(a)
    1 ↔ 1
    6(5482249-5492133)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr5a1 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 73.19(n)
    79.82(a)
      100487444  XM_002932497.2  XP_002932543.2 
    zebrafish
    (Danio rerio)
    Actinopterygii htr5al1 5-hydroxytryptamine (serotonin) receptor 5A like 73.43(n)
    78.82(a)
      368475  NM_001007121.2  NP_001007122.1 


    ENSEMBL Gene Tree for HTR5A (if available)
    TreeFam Gene Tree for HTR5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR5A gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  
    ADRA1A2  HTR1E2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for HTR5A using alignment to 5 protein entries:     5HT5A_HUMAN (see all proteins) (see all similar genes):
    HTR2B    LPAR1    HTR7    alpha 1c-adrenoceptor subtype    TAAR2    HTR1F
    ADORA2A    ADRA1B    HTR1D    HTR2A    ADRA1D    HTR1E
    DRD1    ADRA1A    HTR1B    TACR3    ADRB3    CHRM2

    HTR5A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HTR5A
    PGOHUM00000240882


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR5A (see all 486)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357534
    A colorectal cancer sample4--see VAR_0357532 R C mis40--------
    rs1856282401,2
    --154865273(+) TTCCAC/TGTGTA 1 -- int10--------
    rs22181871,2
    C,F,H--154865283(-) TGGACG/CCTCAT 1 -- int126Minor allele frequency- C:0.14NS EA NA WA CSA 2284
    rs13718211,2
    C,F,H--154865301(-) CCTGGC/TCTGGA 1 -- int126Minor allele frequency- T:0.21MN NS EA NA CSA WA 2264
    rs18220871,2
    C,F,A,H--154865454(-) TTTTAT/CAGGAA 1 -- int121Minor allele frequency- C:0.16MN NS EA NA CSA WA 1724
    rs602828431,2
    C--154865543(+) ACACACACA/-  
            
    TATAT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1124599261,2
    C--154865552(+) ACACAC/TATATA 1 -- int10--------
    rs1126541571,2
    C--154865554(+) ACATAC/TATATA 1 -- int10--------
    rs2001159791,2
    C--154865560(+) ATATAC/TATATG 1 -- int10--------
    rs77828281,2
    A--154865575(+) tgtgtA/Gtatat 1 -- int10--------

    HapMap Linkage Disequilibrium report for HTR5A (154862034 - 154877459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HTR5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735525CNV Deletion23290073
    nsv821049CNV Duplication20802225
    nsv513740CNV Insertion21212237
    nsv824406CNV Loss20364138
    nsv512006CNV Loss21212237
    nsv824407CNV Loss20364138
    esv9298CNV Loss19470904
    nsv8239CNV Loss18304495
    nsv366608CNV Loss16902084

    Human Gene Mutation Database (HGMD): HTR5A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR5A
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601305    OMIM disorders: --

    12 diseases for HTR5A:    About MalaCards
    autistic disorder    seckel syndrome    chronic fatigue syndrome    holoprosencephaly
    alcohol dependence    attention deficit hyperactivity disorder    anorexia nervosa    mood disorder
    breast and colorectal cancer    migraine    schizophrenia    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for HTR5A:
    Holoprosencephaly

    HTR5A for disorders           About GeneDecksing

    Genetic Association Database (GAD): HTR5A
    Human Genome Epidemiology (HuGE) Navigator: HTR5A (15 documents)

    Export disorders for HTR5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR5A gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with HTR5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterisation of the human 5-HT5A serotonin receptor. (PubMed id 7988681)1, 2, 3 Rees S....Lee M. (FEBS Lett. 1994)
    2. [Alcohol dependence and polymorphisms of serotonin-related genes]. (PubMed id 15581469)1, 4, 9 Gorwood P....Hamon M. (Med Sci (Paris) 2004)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study. (PubMed id 19381154)1, 4 Brezo J....Turecki G. (Mol. Psychiatry 2010)
    7. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)1, 4 Yosifova A....Nakamura Y. (J Affect Disord 2009)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    10. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. (PubMed id 18079067)1, 4 Smith A.K....Rajeevan M.S. (Psychoneuroendocrinology 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3361 HGNC: 5300 AceView: HTR5A Ensembl:ENSG00000157219 euGenes: HUgn3361
    ECgene: HTR5A Kegg: 3361 H-InvDB: HTR5A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HTR5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HTR5A gene:
    Search GeneIP for patents involving HTR5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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