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Aliases for HTR5A Gene

Aliases for HTR5A Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled 2 3
  • Serotonin Receptor 5A 3 4
  • 5-HT-5A 3 4
  • 5-HT-5 3 4
  • 5-HT5A 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 5A 2
  • 5-Hydroxytryptamine Receptor 5A 3

External Ids for HTR5A Gene

Previous GeneCards Identifiers for HTR5A Gene

  • GC07P153085
  • GC07P154176
  • GC07P154253
  • GC07P154299
  • GC07P154492
  • GC07P154862
  • GC07P148594

Summaries for HTR5A Gene

Entrez Gene Summary for HTR5A Gene

  • The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR5A Gene

HTR5A (5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR5A include autistic disorder. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR5A Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

Tocris Summary for HTR5A Gene

  • Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans

Gene Wiki entry for HTR5A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR5A Gene

Genomics for HTR5A Gene

Regulatory Elements for HTR5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR5A Gene

155,070,324 bp from pter
155,087,392 bp from pter
17,069 bases
Plus strand

Genomic View for HTR5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR5A Gene

Proteins for HTR5A Gene

  • Protein details for HTR5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 5A
    Protein Accession:
    Secondary Accessions:
    • Q2M2D2

    Protein attributes for HTR5A Gene

    357 amino acids
    Molecular mass:
    40255 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR5A Gene

Proteomics data for HTR5A Gene at MOPED

Post-translational modifications for HTR5A Gene

  • Glycosylation at Asn6 and Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR5A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR5A Gene

Domains for HTR5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR5A: view

Function for HTR5A Gene

Molecular function for HTR5A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 5A,G protein coupled receptor superfamily,unlikely to be associated with autistic disorder
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

Gene Ontology (GO) - Molecular Function for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 7988681
genes like me logo Genes that share ontologies with HTR5A: view

Phenotypes for HTR5A Gene

genes like me logo Genes that share phenotypes with HTR5A: view

Animal Models for HTR5A Gene

MGI Knock Outs for HTR5A:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR5A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR5A Gene

Localization for HTR5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR5A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HTR5A Gene COMPARTMENTS Subcellular localization image for HTR5A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR5A: view

Pathways for HTR5A Gene

genes like me logo Genes that share pathways with HTR5A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HTR5A Gene

Gene Ontology (GO) - Biological Process for HTR5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 7988681
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA --
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007420 brain development --
GO:0019933 cAMP-mediated signaling IEA --
genes like me logo Genes that share ontologies with HTR5A: view

Compounds for HTR5A Gene

(3) Drugbank Compounds for HTR5A Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
132539-06-1 Target antagonist approved, investigational
  • Saphris
65576-45-6 11954293 Target antagonist approved
  • 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine
1977-10-2 3964 Target binder approved

(1) Tocris Compounds for HTR5A Gene

Compound Action Cas Number
SB 699551 Selective 5-ht5a antagonist [864741-95-7]

(37) ApexBio Compounds for HTR5A Gene

Compound Action Cas Number
Asenapine Inhibits adrenergic receptor/5-HT receptor [85650-56-2]
Bilobalide Neuroprotective agent [33570-04-6]
Blonanserin Atypical antipsychotic [132810-10-7]
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker [17321-77-6]
Dapoxetine HCl Selective serotonin reuptake inhibitor [129938-20-1]
Desvenlafaxine [93413-62-8]
Desvenlafaxine Succinate [386750-22-7]
Duloxetine HCl [136434-34-9]
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor [219861-08-2]
Fenspiride HCl [5053-8-7]
Fluoxetine HCl "Serotonin reuptake inhibitor,selective" [56296-78-7]
Fluvoxamine maleate "Serotonin reuptake inhibitor,selective,antidepressant" [61718-82-9]
Ketanserin [74050-98-9]
Lorcaserin HCl [846589-98-8]
LY310762 [192927-92-7]
Milnacipran HCl [101152-94-7]
Mosapride Citrate 5-HT receptor agonist [112885-42-4]
Naratriptan [143388-64-1]
Olanzapine [132539-06-1]
Ondansetron [99614-02-5]
Palonosetron HCl [135729-62-3]
Pizotifen Malate [5189-11-7]
Risperidone SR-2A inhibitor [106266-06-2]
Rizatriptan Benzoate [145202-66-0]
SB271046 [209481-20-9]
SEA0400 Specific inhibitor of Na+/Ca2+ exchange [223104-29-8]
Sertraline HCl [79559-97-0]
Tianeptine sodium "5-HT uptake facilitator,selective,antidepressant" [30123-17-2]
Trazodone HCl Antidepressant [25332-39-2]
Tropisetron [105826-92-4]
Urapidil HCl [64887-14-5]
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor [99300-78-4]
Vortioxetine 5-HT receptors antagonist [508233-74-7]
Vortioxetine (Lu AA21004) HBr "5-HT receptor modulator, antidepressant and anxiolytic" [960203-27-4]
VUF 10166 [155584-74-0]
Ziprasidone HCl Serotonin and dopamine receptor antagonist [122883-93-6]
Zolmitriptan [139264-17-8]

(1) HMDB Compounds for HTR5A Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-(2-Aminoethyl)-1H-indol-5-ol

(20) IUPHAR Ligand for HTR5A Gene

Ligand Type Action Affinity Pubmed IDs
[125I]LSD Agonist Full agonist 9.7
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
ergotamine Agonist Full agonist 8.6
SB 699551 Antagonist Antagonist 8.2
EMDT Agonist Full agonist 7.8
MPDT Antagonist Antagonist 7.7
(-)-propranolol Antagonist Antagonist 7.5
ritanserin Antagonist Antagonist 7.4
metergoline Antagonist Antagonist 7.4
yohimbine Antagonist Antagonist 7.3
methysergide Antagonist Antagonist 6.8
clozapine Antagonist Antagonist 6.7
ketanserin Inhibitor Inhibition 6.3
RU 24969 Agonist Full agonist 6.2
5-CT Agonist Full agonist 6.1
donitriptan Agonist Partial agonist 5.6
sumatriptan Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
[3H]5-CT Agonist Agonist
genes like me logo Genes that share compounds with HTR5A: view

Transcripts for HTR5A Gene

mRNA/cDNA for HTR5A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR5A Gene

5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR5A Gene

No ASD Table

Relevant External Links for HTR5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR5A Gene

mRNA expression in normal human tissues for HTR5A Gene

mRNA differential expression in normal tissues according to GTEx for HTR5A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (8.1), Brain - Cerebellum (7.5), Brain - Frontal Cortex (BA9) (7.4), Brain - Cortex (6.1), Brain - Anterior cingulate cortex (BA24) (5.3), and Brain - Hypothalamus (4.1).

SOURCE GeneReport for Unigene cluster for HTR5A Gene Hs.744621

genes like me logo Genes that share expressions with HTR5A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for HTR5A Gene

Orthologs for HTR5A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR5A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HTR5A 35
  • 87.3 (n)
  • 85.15 (a)
HTR5A 36
  • 85 (a)
(Canis familiaris)
Mammalia HTR5A 35
  • 88.52 (n)
  • 90.76 (a)
HTR5A 36
  • 90 (a)
(Mus musculus)
Mammalia Htr5a 35
  • 84.22 (n)
  • 87.96 (a)
Htr5a 16
Htr5a 36
  • 88 (a)
(Pan troglodytes)
Mammalia HTR5A 35
  • 99.35 (n)
  • 98.88 (a)
HTR5A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Htr5a 35
  • 84.41 (n)
  • 88.24 (a)
(Monodelphis domestica)
Mammalia HTR5A 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia HTR5A 36
  • 90 (a)
(Gallus gallus)
Aves HTR5A 35
  • 77.56 (n)
  • 80 (a)
HTR5A 36
  • 80 (a)
(Anolis carolinensis)
Reptilia HTR5A 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr5a 35
  • 73.19 (n)
  • 79.82 (a)
(Danio rerio)
Actinopterygii htr5al 35
  • 73.43 (n)
  • 78.82 (a)
htr5a 36
  • 77 (a)
htr5al 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 46 (a)
5-HT1B 37
  • 44 (a)
CG6989 37
  • 32 (a)
Species with no ortholog for HTR5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR5A Gene

Gene Tree for HTR5A (if available)
Gene Tree for HTR5A (if available)

Paralogs for HTR5A Gene

Paralogs for HTR5A Gene Pseudogenes for HTR5A Gene

genes like me logo Genes that share paralogs with HTR5A: view

Variants for HTR5A Gene

Sequence variations from dbSNP and Humsavar for HTR5A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs731107 -- 155,081,093(+) TTTGA(C/T)TCATA intron-variant
rs732050 -- 155,081,685(-) ATCCA(C/T)GATTG intron-variant
rs753116 -- 155,086,638(+) CATAC(A/G)CTATC utr-variant-3-prime
rs753117 -- 155,086,705(+) TTGCT(C/T)CCATT utr-variant-3-prime
rs753118 -- 155,086,889(+) CTAAT(G/T)GTGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR5A Gene

Variant ID Type Subtype PubMed ID
nsv366608 CNV Loss 16902084
nsv8239 CNV Loss 18304495
nsv821049 CNV Duplication 20802225
nsv824406 CNV Loss 20364138
nsv824407 CNV Loss 20364138
nsv513740 CNV Insertion 21212237
nsv512006 CNV Loss 21212237
esv9298 CNV Loss 19470904
esv2735525 CNV Deletion 23290073

Relevant External Links for HTR5A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR5A Gene

Disorders for HTR5A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTR5A Gene in MalaCards »

(1) Disease for HTR5A Gene

(1) University of Copenhagen DISEASES for HTR5A Gene

Relevant External Links for HTR5A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR5A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for HTR5A Gene

Publications for HTR5A Gene

  1. Cloning and characterisation of the human 5-HT5A serotonin receptor. (PMID: 7988681) Rees S. … Lee M. (FEBS Lett. 1994) 2 3 4
  2. [Alcohol dependence and polymorphisms of serotonin-related genes]. (PMID: 15581469) Gorwood P. … Hamon M. (Med Sci (Paris) 2004) 3 23 48
  3. Association of a 5-HT(5A) receptor polymorphism, Pro15Ser, to schizophrenia. (PMID: 11317225) Iwata N. … Goldman D. (Mol. Psychiatry 2001) 3 48
  4. Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. (PMID: 11343685) Grailhe R. … Hen R. (Eur. J. Pharmacol. 2001) 3 23
  5. Recombinant human serotonin 5A receptors stably expressed in C6 glioma cells couple to multiple signal transduction pathways. (PMID: 12558985) Noda M. … Wada K. (J. Neurochem. 2003) 3 23

Products for HTR5A Gene

Sources for HTR5A Gene

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