Aliases for HTR5A Gene
External Ids for HTR5A Gene
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
GeneCards Summary for HTR5A Gene
HTR5A (5-Hydroxytryptamine (Serotonin) Receptor 5A, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR5A include autistic disorder. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for HTR5A Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans