Aliases for HTR4 Gene
Aliases for HTR4 Gene
External Ids for HTR4 Gene
- HGNC: 5299
- Entrez Gene: 3360
- Ensembl: ENSG00000164270
- OMIM: 602164
- UniProtKB: Q13639
Previous GeneCards Identifiers for HTR4 Gene
- GC05M147904
- GC05M148425
- GC05M147859
- GC05M147810
- GC05M142977
Summaries for HTR4 Gene
-
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
GeneCards Summary for HTR4 Gene
HTR4 (5-Hydroxytryptamine Receptor 4) is a Protein Coding gene. Diseases associated with HTR4 include Constipation and Irritable Bowel Syndrome. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is TAAR1.
UniProtKB/Swiss-Prot for HTR4 Gene
-
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
-
Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.
Additional gene information for HTR4 Gene
- Monarch Initiative
- Search for HTR4 at DataMed
- Search for HTR4 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR4 Gene
Genomics for HTR4 Gene
GeneHancer (GH) Regulatory Elements for HTR4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH05I148653 | Promoter | 0.6 | EPDnew | 560.7 | +23.6 | 23645 | 0.1 | EZH2 | HTR4 GC05P148648 GC05P148649 GC05P148650 GC05M148672 | |
GH05I148654 | Promoter | 0.6 | EPDnew | 560.7 | +23.1 | 23050 | 0.1 | EZH2 | HTR4 GC05P148648 GC05P148649 GC05P148650 GC05M148672 | |
GH05I148659 | Enhancer | 0.8 | ENCODE | 0.4 | +17.0 | 17017 | 2.2 | HDAC1 MEIS2 LEF1 PKNOX1 TEAD4 TAL1 TCF12 CTBP1 FOXK2 ARID2 | GC05P148648 GC05P148649 GC05P148650 GC05M148672 HTR4 | |
GH05I148639 | Enhancer | 0.9 | ENCODE | 0.3 | +37.9 | 37916 | 0.5 | PKNOX1 SMAD1 ARNT NCOA2 TCF12 GATA2 ATF7 NCOA1 MBD2 MEF2D | GC05P148643 GC05P148622 HTR4 | |
GH05I148622 | Enhancer | 0.8 | ENCODE | 0.2 | +53.9 | 53868 | 2.3 | HDAC1 MXI1 PKNOX1 TEAD4 TAL1 JUN MAX CEBPG RFX5 FOSL1 | GC05P148622 GC05P148643 HTR4 |
Regulatory Element Products
Genomic Locations for HTR4 Gene
- chr5:148,451,032-148,677,235
- (GRCh38/hg38)
- Size:
- 226,204 bases
- Orientation:
- Minus strand
- chr5:147,830,595-148,056,798
- (GRCh37/hg19)
Genomic View for HTR4 Gene
- Cytogenetic band:
-
- 5q32 by Ensembl
- 5q32 by Entrez Gene
- 5q32 by HGNC


RefSeq DNA sequence for HTR4 Gene
Proteins for HTR4 Gene
-
Protein details for HTR4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13639-5HT4R_HUMAN
- Recommended name:
- 5-hydroxytryptamine receptor 4
- Protein Accession:
- Q13639
- C4WYH4
- Q546Q1
- Q684M0
- Q712M9
- Q96KH9
- Q96KI0
- Q9H199
- Q9NY73
- Q9UBM6
- Q9UBT4
- Q9UE22
- Q9UE23
- Q9UQR6
Protein attributes for HTR4 Gene
- Size:
- 388 amino acids
- Molecular mass:
- 43761 Da
- Quaternary structure:
-
- Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).
Post-translational modifications for HTR4 Gene
Other Protein References for HTR4 Gene
Antibody Products
- R&D Systems Antibodies for HTR4 (5-HT4)
- Cell Signaling Technology (CST) Antibodies for HTR4 (5-HT(4))
-
Custom Antibody ServicesOriGene Antibodies for HTR4
- Novus Biologicals Antibodies for HTR4
-
Abcam antibodies for HTR4
-
Cloud-Clone Corp. Antibodies for HTR4
- Invitrogen Antibodies for HTR4
- antibodies-online: Search results for 122 available Serotonin Receptor 4 Antibodies ranked by validation data
- Compare Top Serotonin Receptor 4 Antibodies
-
Recommended
- 1 FACS Antibody (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 28 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-human)
- 5 IHC Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 63 WB Antibodies (anti-human)
- 1 FACS Antibody (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 27 WB Antibodies (anti-mouse)
- GeneTex HTR4 antibody for HTR4
-
Santa Cruz Biotechnology (SCBT) Antibodies for HTR4
Protein Products
-
OriGene Purified Proteins for HTR4
- Search Origene for MassSpec and Protein Over-expression Lysates for HTR4
- Origene Custom Protein Services for HTR4
-
Cloud-Clone Corp. Proteins for HTR4
- Search GeneTex for Proteins for HTR4
-
Abcam proteins for HTR4
Assay Products
-
Cloud-Clone Corp. Assay Kits for HTR4
No data available for DME Specific Peptides for HTR4 Gene
Domains & Families for HTR4 Gene
Gene Families for HTR4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for HTR4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HTR4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13639- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for HTR4 Gene
Molecular function for HTR4 Gene
- GENATLAS Biochemistry:
- 5-hydroxytryptamine (serotonin) receptor,subtype 4A,and three splice variants 4B,4C,4D,G protein coupled receptor superfamily,activating adenylate cyclase
- UniProtKB/Swiss-Prot Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Phenotypes From GWAS Catalog for HTR4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001594 | NOT trace-amine receptor activity | IBA | -- |
GO:0004930 | G-protein coupled receptor activity | IEA | -- |
GO:0004993 | G-protein coupled serotonin receptor activity | IDA | 16102731 |
Phenotypes for HTR4 Gene
- MGI mutant phenotypes for HTR4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HTR4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HTR4
-
- Search ViGene Biosciences for HTR4
CRISPR Products
-
OriGene CRISPR knockouts for HTR4
- Applied Biological Materials CRISPR for HTR4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR4
- GenScript: Design CRISPR guide RNA sequences for HTR4
miRNA Products
- Search ViGene Biosciences for HTR4
- SwitchGear HTR4 3' UTR sequence
- SwitchGear HTR4 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HTR4
- Browse OriGene Inhibitory RNA Products For HTR4
Clone Products
-
OriGene ORF clones in human for HTR4
- RC210367L1V
- RC210367L2V
- RC211606L1V
- RC211606L2V
- RC217913L1V
- RC217913L2V
- RC211874L1V
- RC211874L2V
- RC224437L1V
- RC224437L2V
- RC218409L1V
- RC218409L2V
- RC210367
- RC210367L1
- RC210367L2
- RG210367
- RC211606
- RC211606L1
- RC211606L2
- RG211606
- RC217913
- RC217913L1
- RC217913L2
- RG217913
- RC211874
- RC211874L1
- RC211874L2
- RG211874
- RC224437
- RC224437L1
- RC224437L2
- RG224437
- RC238051
- RC218409
- RC218409L1
- RC218409L2
- RG218409
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HTR4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HTR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTR4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HTR4
- genomics-online: cdna clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
-
Recommended
- orf clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
-
Recommended
- Applied Biological Materials Clones for HTR4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HTR4 (5-HT4)
Cell Line Products
-
Horizon Cell Lines for HTR4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR4 Gene
Localization for HTR4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HTR4 Gene
- Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IDA | 15925089 |
GO:0005768 | endosome | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA,TAS | -- |
GO:0016020 | membrane | IDA | 16102731 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR4 Gene
Pathways & Interactions for HTR4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Monoamine GPCRs |
.75
|
|
3 | Signaling by GPCR | ||
4 | Development Ligand-independent activation of ESR1 and ESR2 | ||
5 | Calcium signaling pathway |
Pathways by source for HTR4 Gene
2 Cell Signaling Technology pathways for HTR4 Gene
3 BioSystems pathways for HTR4 Gene
8 Reactome pathways for HTR4 Gene
1 PharmGKB pathway for HTR4 Gene
4 KEGG pathways for HTR4 Gene
2 GeneGo (Thomson Reuters) pathways for HTR4 Gene
1 Qiagen pathway for HTR4 Gene
Interacting Proteins for HTR4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | 9603189 |
GO:0007214 | gamma-aminobutyric acid signaling pathway | IBA | -- |
GO:0007268 | chemical synaptic transmission | IEA | -- |
No data available for SIGNOR curated interactions for HTR4 Gene
Drugs & Compounds for HTR4 Gene
(123) Drugs for HTR4 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cisapride | Approved, Investigational, Withdrawn | Pharma | Partial agonist, Agonist, Target, agonist | 5 | ||
Tegaserod | Approved, Investigational, Withdrawn | Pharma | Antagonist, Target, antagonist, partial agonist, agonist | 28 | ||
Tropisetron | Approved, Investigational | Pharma | Antagonist, antagonist | 23 | ||
Prucalopride | Approved | Pharma | Partial agonist, Agonist, Target, agonist | 5-HT4A and 5-HT4B receptor agonist | 0 | |
Ondansetron | Approved | Pharma | Target, agonist | 342 |
(5) Tocris Compounds for HTR4 Gene
Compound | Action | Cas Number |
---|---|---|
2-[1-(4-Piperonyl)piperazinyl]benzothiazole | 5-HT4 agonist. Also 5-HT3 antagonist | 155106-73-3 |
Cisapride | 5-HT4 agonist; stimulates intestinal ACh release | 81098-60-4 |
Mosapride citrate | 5-HT4 agonist and 5-HT3 antagonist | 112885-42-4 |
RS 67333 hydrochloride | 5-HT4 partial agonist | 168986-60-5 |
RS 67506 hydrochloride | 5-HT4 partial agonist | 168986-61-6 |
(78) ApexBio Compounds for HTR4 Gene
Compound | Action | Cas Number |
---|---|---|
(±)-MDMA hydrochloride | 92279-84-0 | |
2-Methyl-5-hydroxytryptamine hydrochloride | 845861-49-6 | |
Amitriptyline HCl | Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor | 549-18-8 |
Asenapine | Inhibits adrenergic receptor/5-HT receptor | 85650-56-2 |
Bilobalide | Neuroprotective agent | 33570-04-6 |
BIMU 8 | Potent 5-HT4 receptor full agonist | 134296-40-5 |
Blonanserin | Atypical antipsychotic | 132810-10-7 |
BTS 54-505 hydrochloride | Potent SNRI,sibutramine metabolite | 84484-78-6 |
Cisapride | 81098-60-4 | |
CJ 033466 | 519148-48-2 | |
Clomipramine HCl | SERT/NET dopamine transporter (DAT) blocker | 17321-77-6 |
Clozapine N-oxide | Metabolite of clozapine | 34233-69-7 |
Dapoxetine HCl | Selective serotonin reuptake inhibitor | 129938-20-1 |
Desvenlafaxine | 93413-62-8 | |
Desvenlafaxine Succinate | 386750-22-7 | |
Dexfenfluramine hydrochloride | 3239-45-0 | |
Dihydroergotamine mesylate | 6190-39-2 | |
DOB hydrochloride | 29705-96-2 | |
DOI hydrochloride | 42203-78-1 | |
Duloxetine HCl | 136434-34-9 | |
Eltoprazine hydrochloride | 98206-09-8 | |
Escitalopram Oxalate | Serotonin(5-HT) reuptake (SSRI) inhibitor | 219861-08-2 |
Fenspiride HCl | 5053-08-7 | |
Fluoxetine HCl | Serotonin reuptake inhibitor,selective | 56296-78-7 |
Fluvoxamine maleate | Serotonin reuptake inhibitor,selective,antidepressant | 61718-82-9 |
GR 113808 | 144625-51-4 | |
GR 125487 sulfamate | 859502-43-5 | |
GR 46611 | 185259-85-2 | |
Ketanserin | 74050-98-9 | |
Lorcaserin HCl | 846589-98-8 | |
LY310762 | 192927-92-7 | |
m-CPP hydrochloride | 13078-15-4 | |
Methysergide maleate | 129-49-7 | |
Milnacipran HCl | 101152-94-7 | |
ML 10302 hydrochloride | 186826-17-5 | |
Mosapride | 112885-41-3 | |
Mosapride Citrate | 5-HT receptor agonist | 112885-42-4 |
MS 245 oxalate | 275363-58-1 | |
NAD 299 hydrochloride | 184674-99-5 | |
Naratriptan | 143388-64-1 | |
Olanzapine | 132539-06-1 | |
Ondansetron | 99614-02-5 | |
Palonosetron HCl | 135729-62-3 | |
Pizotifen Malate | 5189-11-7 | |
Prucalopride Succinat | 179474-85-2 | |
Psilocin | 520-53-6 | |
Risperidone | SR-2A inhibitor | 106266-06-2 |
Rizatriptan Benzoate | 145202-66-0 | |
RS 23597-190 hydrochloride | 149719-06-2 | |
RS 39604 hydrochloride | 167710-87-4 | |
RS 67333 hydrochloride | 168986-60-5 | |
RS 67506 hydrochloride | 168986-61-6 | |
RU 24969 | 66611-26-5 | |
Sarpogrelate hydrochloride | 135159-51-2 | |
SB 200646 hydrochloride | 143797-62-0 | |
SB 203186 hydrochloride | 207572-69-8 | |
SB 204070 | 148688-01-1 | |
SB 242084 | 1215566-78-1 | |
SB 243213 dihydrochloride | 200940-23-4 | |
SB 258719 hydrochloride | 1217674-10-6 | |
SB271046 | 209481-20-9 | |
SDZ 205-557 hydrochloride | 1197334-02-3 | |
SEA0400 | Specific inhibitor of Na+/Ca2+ exchange | 223104-29-8 |
Sertraline HCl | 79559-97-0 | |
Tandospirone | Anxiolytic and antidepressant reagent | 87760-53-0 |
Tegaserod maleate | 189188-57-6 | |
Tianeptine sodium | 5-HT uptake facilitator,selective,antidepressant | 30123-17-2 |
Trazodone HCl | Antidepressant | 25332-39-2 |
Tropisetron | 105826-92-4 | |
Urapidil HCl | 64887-14-5 | |
Venlafaxine | Dual serotonin/noradrenalin re-uptake inhibitor | 99300-78-4 |
Vortioxetine | 5-HT receptors antagonist | 508233-74-7 |
Vortioxetine (Lu AA21004) HBr | 5-HT receptor modulator, antidepressant and anxiolytic | 960203-27-4 |
VUF 10166 | 155584-74-0 | |
WY 45233 succinate | 448904-47-0 | |
Ziprasidone HCl | Serotonin and dopamine receptor antagonist | 122883-93-6 |
Ziprasidone hydrochloride monohydrate | 5-HT (serotonin)/dopamine receptor antagonist | 138982-67-9 |
Zolmitriptan | 139264-17-8 |
Transcripts for HTR4 Gene
mRNA/cDNA for HTR4 Gene
- (7) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (113) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HTR4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HTR4
- Applied Biological Materials CRISPR for HTR4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HTR4
- GenScript: Design CRISPR guide RNA sequences for HTR4
miRNA Products
- Search ViGene Biosciences for HTR4
- SwitchGear HTR4 3' UTR sequence
- SwitchGear HTR4 3' UTR sequence
- Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HTR4
- Browse OriGene Inhibitory RNA Products For HTR4
Clone Products
-
OriGene ORF clones in human for HTR4
- RC210367L1V
- RC210367L2V
- RC211606L1V
- RC211606L2V
- RC217913L1V
- RC217913L2V
- RC211874L1V
- RC211874L2V
- RC224437L1V
- RC224437L2V
- RC218409L1V
- RC218409L2V
- RC210367
- RC210367L1
- RC210367L2
- RG210367
- RC211606
- RC211606L1
- RC211606L2
- RG211606
- RC217913
- RC217913L1
- RC217913L2
- RG217913
- RC211874
- RC211874L1
- RC211874L2
- RG211874
- RC224437
- RC224437L1
- RC224437L2
- RG224437
- RC238051
- RC218409
- RC218409L1
- RC218409L2
- RG218409
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HTR4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HTR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTR4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HTR4
- genomics-online: cdna clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
-
Recommended
- orf clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
-
Recommended
- Applied Biological Materials Clones for HTR4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for HTR4 (5-HT4)
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||
SP9: |
Expression for HTR4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HTR4 Gene
NURSA nuclear receptor signaling pathways regulating expression of HTR4 Gene:
HTR4SOURCE GeneReport for Unigene cluster for HTR4 Gene:
Hs.483773mRNA Expression by UniProt/SwissProt for HTR4 Gene:
Q13639-5HT4R_HUMANEvidence on tissue expression from TISSUES for HTR4 Gene
- Intestine(4.6)
- Nervous system(4.6)
- Heart(4.4)
- Stomach(2.6)
- Muscle(2.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for HTR4
-
OriGene qPCR primer pairs for HTR4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR4 Gene
Orthologs for HTR4 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | HTR4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | HTR4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | HTR4 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | HTR4 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Htr4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Htr4 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | HTR4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | HTR4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | HTR4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493952 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | HTR4 34 |
|
OneToOne | |
LOC556843 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | oa2 33 34 |
|
||
CG6919 35 |
|
|
|||
CG6989 35 |
|
|
|||
DopR 35 |
|
|
|||
Octbeta2R 34 |
|
ManyToMany |
- Species where no ortholog for HTR4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HTR4 Gene
(29) SIMAP similar genes for HTR4 Gene using alignment to 3 proteins:
Variants for HTR4 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000000263 | -- | 148,481,530(-) | A/G | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant | |
rs1000004399 | -- | 148,452,819(-) | A/T | genic_downstream_transcript_variant, intron_variant | |
rs1000011599 | -- | 148,492,384(-) | T/A | intron_variant | |
rs1000079867 | -- | 148,622,477(-) | T/C | intron_variant | |
rs1000084690 | -- | 148,483,848(-) | T/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3305996 | CNV | mobile element insertion | 20981092 |
esv3406555 | CNV | insertion | 20981092 |
esv3607115 | CNV | loss | 21293372 |
esv3607116 | CNV | loss | 21293372 |
esv3607118 | CNV | loss | 21293372 |
esv3607119 | CNV | loss | 21293372 |
nsv1152791 | CNV | duplication | 26484159 |
nsv328933 | CNV | deletion | 16902084 |
nsv523792 | CNV | loss | 19592680 |
nsv830516 | CNV | loss | 17160897 |
Additional Variant Information for HTR4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HTR4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR4 Gene
Disorders for HTR4 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
constipation |
|
|
irritable bowel syndrome |
|
|
gastrointestinal system disease |
|
|
colonic pseudo-obstruction |
|
|
pylorospasm |
|
|
Additional Disease Information for HTR4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HTR4 Gene
Publications for HTR4 Gene
- Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. (PMID: 12898568) Suzuki T … Ozaki N (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2003) 3 22 44 58
- Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. (PMID: 9603189) Blondel O … Fischmeister R (Journal of neurochemistry 1998) 3 4 22 58
- Expression of serotonin receptor mRNAs in blood vessels. (PMID: 7656980) Ullmer C … Lübbert H (FEBS letters 1995) 3 4 22 58
- Association study of the serotoninergic system in migraine in the Spanish population. (PMID: 19455600) Corominas R … Cormand B (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
- Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. (PMID: 19892407) Hirata Y … Kennedy JL (Psychiatry research 2010) 3 44 58
Products for HTR4 Gene
- R&D Systems Antibodies for HTR4 (5-HT4)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for HTR4 (5-HT4)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HTR4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HTR4
- Search Origene for MassSpec and Protein Over-expression Lysates for HTR4
- Origene Custom Protein Services for HTR4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for HTR4
- Browse OriGene Inhibitory RNA Products For HTR4
- OriGene qPCR primer pairs and template standards for HTR4
- OriGene qPCR primer pairs for HTR4
- OriGene CRISPR knockouts for HTR4
- OriGene ORF clones in human for HTR4
- RC210367L1V
- RC210367L2V
- RC211606L1V
- RC211606L2V
- RC217913L1V
- RC217913L2V
- RC211874L1V
- RC211874L2V
- RC224437L1V
- RC224437L2V
- RC218409L1V
- RC218409L2V
- RC210367
- RC210367L1
- RC210367L2
- RG210367
- RC211606
- RC211606L1
- RC211606L2
- RG211606
- RC217913
- RC217913L1
- RC217913L2
- RG217913
- RC211874
- RC211874L1
- RC211874L2
- RG211874
- RC224437
- RC224437L1
- RC224437L2
- RG224437
- RC238051
- RC218409
- RC218409L1
- RC218409L2
- RG218409
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HTR4
- GenScript: Next-day shipping of latest version cDNA ORF clones for HTR4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HTR4
- GenScript Custom Assay Services for HTR4
- GenScript Custom overexpressing Cell Line Services for HTR4
- GenScript: Design CRISPR guide RNA sequences for HTR4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HTR4
- Cell Signaling Technology (CST) Antibodies for HTR4 (5-HT(4))
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HTR4
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HTR4
- Novus Biologicals proteins and lysates for HTR4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HTR4
- Abcam proteins for HTR4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for HTR4
- Cloud-Clone Corp. Proteins for HTR4
- Cloud-Clone Corp. Assay Kits for HTR4
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for HTR4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for HTR4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HTR4
- VectorBuilder custom plasmid, inducible vectors for HTR4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HTR4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HTR4
- antibodies-online: Search results for 122 available Serotonin Receptor 4 Antibodies ranked by validation data
- Compare Top Serotonin Receptor 4 Antibodies
- Recommended
- 27 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 63 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 21 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 28 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Search results for 3 available Serotonin Receptor 4 Elisa Kits ranked by validation data
- Compare Top Serotonin Receptor 4 Elisa Kits
- Recommended
- antibodies-online: Search results for 4 available Serotonin Receptor 4 Proteins ranked by validation data
- Compare Top Serotonin Receptor 4 Proteins
- GeneTex HTR4 antibody for HTR4
- Search GeneTex for Proteins for HTR4
- Search ViGene Biosciences for HTR4
- Santa Cruz Biotechnology (SCBT) Antibodies for HTR4
- Search Santa Cruz Biotechnology (SCBT) for HTR4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HTR4
- Horizon Cell Lines for HTR4
- genomics-online: cdna clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
- Recommended
- orf clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
- Recommended
- genomics-online: primer clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 137 available Serotonin Receptor 4 gene related products
- Overview of 137 available Serotonin Receptor 4 gene related products
- Recommended
Sources for HTR4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew