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Aliases for HTR4 Gene

Aliases for HTR4 Gene

  • 5-Hydroxytryptamine Receptor 4 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 4, G Protein-Coupled 2 3
  • 5-HT4 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 4 2
  • Cardiac 5-HT4 Receptor 3
  • Serotonin Receptor 4 4
  • 5-HT4R 3
  • 5-HT-4 4

External Ids for HTR4 Gene

Previous GeneCards Identifiers for HTR4 Gene

  • GC05M147904
  • GC05M148425
  • GC05M147859
  • GC05M147810
  • GC05M142977

Summaries for HTR4 Gene

Entrez Gene Summary for HTR4 Gene

  • This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

GeneCards Summary for HTR4 Gene

HTR4 (5-Hydroxytryptamine Receptor 4) is a Protein Coding gene. Diseases associated with HTR4 include Constipation and Gastrointestinal System Disease. Among its related pathways are Signaling by GPCR and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include G-protein coupled receptor activity and trace-amine receptor activity. An important paralog of this gene is DRD1.

UniProtKB/Swiss-Prot for HTR4 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Tocris Summary for HTR4 Gene

  • Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.

Gene Wiki entry for HTR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR4 Gene

Genomics for HTR4 Gene

Regulatory Elements for HTR4 Gene

Genomic Location for HTR4 Gene

148,451,032 bp from pter
148,677,235 bp from pter
226,204 bases
Minus strand

Genomic View for HTR4 Gene

Genes around HTR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR4 Gene

Proteins for HTR4 Gene

  • Protein details for HTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 4
    Protein Accession:
    Secondary Accessions:
    • C4WYH4
    • Q546Q1
    • Q684M0
    • Q712M9
    • Q96KH9
    • Q96KI0
    • Q9H199
    • Q9NY73
    • Q9UBM6
    • Q9UBT4
    • Q9UE22
    • Q9UE23
    • Q9UQR6

    Protein attributes for HTR4 Gene

    388 amino acids
    Molecular mass:
    43761 Da
    Quaternary structure:
    • Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).

    Alternative splice isoforms for HTR4 Gene

neXtProt entry for HTR4 Gene

Post-translational modifications for HTR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTR4 (5-HT(4))
  • Santa Cruz Biotechnology (SCBT) Antibodies for HTR4

No data available for DME Specific Peptides for HTR4 Gene

Domains & Families for HTR4 Gene

Suggested Antigen Peptide Sequences for HTR4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR4: view

Function for HTR4 Gene

Molecular function for HTR4 Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 4A,and three splice variants 4B,4C,4D,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Gene Ontology (GO) - Molecular Function for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IDA,TAS 16102731
genes like me logo Genes that share ontologies with HTR4: view
genes like me logo Genes that share phenotypes with HTR4: view

Animal Models for HTR4 Gene

MGI Knock Outs for HTR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HTR4 Gene

Localization for HTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR4 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for HTR4 Gene COMPARTMENTS Subcellular localization image for HTR4 gene
Compartment Confidence
endosome 5
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15925089
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0016020 membrane IDA 16102731
genes like me logo Genes that share ontologies with HTR4: view

Pathways & Interactions for HTR4 Gene

genes like me logo Genes that share pathways with HTR4: view

Gene Ontology (GO) - Biological Process for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9351641
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9603189
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007214 gamma-aminobutyric acid signaling pathway IBA --
genes like me logo Genes that share ontologies with HTR4: view

No data available for SIGNOR curated interactions for HTR4 Gene

Drugs & Compounds for HTR4 Gene

(121) Drugs for HTR4 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisapride Approved, Investigational, Withdrawn Pharma Partial agonist, Agonist, agonist, Target 5
Prucalopride Approved Pharma Partial agonist, Agonist, Target, agonist 5-HT4A and 5-HT4B receptor agonist 0
Ondansetron Approved Pharma Target, agonist 309
Metoclopramide Approved, Investigational Pharma Target, agonist Dopamine receptor antagonist 116
Cinitapride Approved Pharma Target, agonist 0

(7) Additional Compounds for HTR4 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Full agonist, Agonist
Full agonist, Agonist

(5) Tocris Compounds for HTR4 Gene

Compound Action Cas Number
BIMU 8 Potent 5-HT4 receptor full agonist 134296-40-5
GR 113808 Potent, selective 5-HT4 antagonist 144625-51-4
GR 125487 sulfamate Potent, selective 5-HT4 antagonist; active in vivo 859502-43-5
RS 39604 hydrochloride 5-HT4 antagonist 167710-87-4
RS 67333 hydrochloride 5-HT4 partial agonist 168986-60-5

(78) ApexBio Compounds for HTR4 Gene

Compound Action Cas Number
(±)-MDMA hydrochloride 92279-84-0
2-Methyl-5-hydroxytryptamine hydrochloride 845861-49-6
Amitriptyline HCl Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor 549-18-8
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Bilobalide Neuroprotective agent 33570-04-6
BIMU 8 Potent 5-HT4 receptor full agonist 134296-40-5
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
Cisapride 81098-60-4
CJ 033466 519148-48-2
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dexfenfluramine hydrochloride 3239-45-0
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Duloxetine HCl 136434-34-9
Eltoprazine hydrochloride 98206-09-8
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 113808 144625-51-4
GR 125487 sulfamate 859502-43-5
GR 46611 185259-85-2
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
Methysergide maleate 129-49-7
Milnacipran HCl 101152-94-7
ML 10302 hydrochloride 186826-17-5
Mosapride 112885-41-3
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Pizotifen Malate 5189-11-7
Prucalopride Succinat 179474-85-2
Psilocin 520-53-6
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
RS 23597-190 hydrochloride 149719-06-2
RS 39604 hydrochloride 167710-87-4
RS 67333 hydrochloride 168986-60-5
RS 67506 hydrochloride 168986-61-6
RU 24969 66611-26-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258719 hydrochloride 1217674-10-6
SB271046 209481-20-9
SDZ 205-557 hydrochloride 1197334-02-3
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
Tegaserod maleate 189188-57-6
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WY 45233 succinate 448904-47-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR4: view

Transcripts for HTR4 Gene

Unigene Clusters for HTR4 Gene

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: -

Relevant External Links for HTR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.1), Small Intestine - Terminal Ileum (x6.1), Brain - Caudate (basal ganglia) (x5.8), Colon - Transverse (x5.3), and Brain - Putamen (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of HTR4 Gene:


SOURCE GeneReport for Unigene cluster for HTR4 Gene:


mRNA Expression by UniProt/SwissProt for HTR4 Gene:

Tissue specificity: Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
genes like me logo Genes that share expression patterns with HTR4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR4 Gene

Orthologs for HTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR4 34 35
  • 99.61 (n)
(Bos Taurus)
Mammalia HTR4 34 35
  • 93.73 (n)
(Canis familiaris)
Mammalia HTR4 34 35
  • 93.63 (n)
(Ornithorhynchus anatinus)
Mammalia HTR4 35
  • 91 (a)
(Mus musculus)
Mammalia Htr4 34 16 35
  • 90.89 (n)
(Rattus norvegicus)
Mammalia Htr4 34
  • 90.56 (n)
(Monodelphis domestica)
Mammalia HTR4 35
  • 78 (a)
(Gallus gallus)
Aves HTR4 34 35
  • 82.6 (n)
(Anolis carolinensis)
Reptilia HTR4 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493952 34
  • 74.52 (n)
(Danio rerio)
Actinopterygii HTR4 35
  • 73 (a)
LOC556843 34
  • 71.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta oa2 34 35
  • 54.34 (n)
CG6919 36
  • 42 (a)
CG6989 36
  • 36 (a)
DopR 36
  • 35 (a)
Octbeta2R 35
  • 26 (a)
Species where no ortholog for HTR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR4 Gene

Gene Tree for HTR4 (if available)
Gene Tree for HTR4 (if available)

Paralogs for HTR4 Gene

Paralogs for HTR4 Gene

genes like me logo Genes that share paralogs with HTR4: view

Variants for HTR4 Gene

Sequence variations from dbSNP and Humsavar for HTR4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035840 -- 148,503,330(+) ggggg(C/G)caata intron-variant
rs10036018 -- 148,468,632(+) AGATG(C/T)CATTT intron-variant
rs10036157 -- 148,570,408(+) TATAA(A/G)GGGAG intron-variant
rs10037376 -- 148,570,611(+) TGGAG(C/T)GCAGA intron-variant
rs10037493 -- 148,475,407(+) GCATC(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR4 Gene

Variant ID Type Subtype PubMed ID
esv3305996 CNV mobile element insertion 20981092
esv3406555 CNV insertion 20981092
esv3607115 CNV loss 21293372
esv3607116 CNV loss 21293372
esv3607118 CNV loss 21293372
esv3607119 CNV loss 21293372
nsv1152791 CNV duplication 26484159
nsv328933 CNV deletion 16902084
nsv523792 CNV loss 19592680
nsv830516 CNV loss 17160897

Variation tolerance for HTR4 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR4 Gene

Disorders for HTR4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for HTR4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrointestinal system disease
  • alimentary system disease
colonic pseudo-obstruction
  • primary chronic pseudo-obstruction of colon
isobutyryl-coa dehydrogenase deficiency
  • irritable bowel syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HTR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HTR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR4 Gene

Publications for HTR4 Gene

  1. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. (PMID: 12898568) Suzuki T. … Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 22 46 64
  2. Cloning, expression, and pharmacology of four human 5- hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. (PMID: 9603189) Blondel O. … Fischmeister R. (J. Neurochem. 1998) 3 4 22 64
  3. Expression of serotonin receptor mRNAs in blood vessels. (PMID: 7656980) Ullmer C. … Luebbert H. (FEBS Lett. 1995) 3 4 22 64
  4. Association study of the serotoninergic system in migraine in the Spanish population. (PMID: 19455600) Corominas R. … Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples. (PMID: 19892407) Hirata Y. … Kennedy J.L. (Psychiatry Res 2010) 3 46 64

Products for HTR4 Gene

Sources for HTR4 Gene

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