HTR4 Gene
protein-coding GIFtS: 66
GCID: GC05M147810
|
|
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled(Previous name: 5-hydroxytryptamine (serotonin) receptor 4 )
| |
Aliases
for HTR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 4, G Protein-Coupled1 2 | | 5-Hydroxytryptamine Receptor 42 | | 5-HT41 2 3 | | Cardiac 5-HT4 Receptor2 | | 5-Hydroxytryptamine (Serotonin) Receptor 41 | | 5-HT-43 | | 5-HT4R2 | | Serotonin Receptor 43 |
Export aliases for HTR4 gene to outside databasesPrevious GC identifers: GC05M147904 GC05M148425 GC05M147859 GC05M142977 |
Summaries
for HTR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HTR4:
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMPproduction in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane proteinthat functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters.Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. (provided byRefSeq, May 2010)
UniProtKB/Swiss-Prot: 5HT4R_HUMAN, Q13639Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteinsthat stimulate adenylate cyclase
 summary
for HTR4: Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle.
The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.
The human 5-HT4 receptor gene has been localized to chromosome 5 (5q31-33).
Gene Wiki entry for HTR4 (5-HT4 receptor)
|
Genomic Views
for HTR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HTR4 gene promoter:
Pax-5 Egr-1 CUTL1 HNF-3beta RORalpha2 Roaz C/EBPalpha AREB6 MEF-2A S8
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31-q33 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q31-q33HTR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M147810: view genomic region
(about GC identifiers)
Start:
|
147,830,595 bp from pter |
End:
|
148,056,798 bp from pter |
Size:
|
226,204 bases |
Orientation:
|
minus strand |
|
Proteins
for HTR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 5HT4R_HUMAN, Q13639 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 4 Size: 388 amino acids; 43761 Da
Subunit: Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interactswith INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts(via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin)
Subcellular location: Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediatesrecruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specializedsubcellular regions, such as microvilli (By similarity)
Secondary accessions: Q546Q1 Q684M0 Q712M9 Q96KH9 Q96KI0 Q9H199 Q9NY73 Q9UBM6 Q9UBT4 Q9UE22 Q9UE23Q9UQR6Alternative splicing: 8 isoforms: Q13639-1 Q13639-2 Q13639-3 Q13639-4 Q13639-5 Q13639-6 Q13639-7 Q13639-8 (Expressed in all cardiovascular tissues analyzed)Explore the universe of human proteins at neXtProt for HTR4: NX_Q13639
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13639
HTR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_000861.1 NP_001035259.1 NP_001035262.2 NP_001035263.1 NP_955525.1
ENSEMBL proteins: ENSP00000428320 ENSP00000430874 ENSP00000430979 ENSP00000435904 ENSP00000427913 ENSP00000367120 ENSP00000353915 ENSP00000430451 ENSP00000429634 ENSP00000346156 ENSP00000314906 ENSP00000355037 Reactome Protein details: Q13639
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
HTR4 for ontologies About GeneDecksing
HTR4 Antibody Products:
Assay Products for HTR4: |
Protein
Domains /
Families
for HTR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13639ProtoNet protein and cluster: Q13639 2 Blocks protein families: IPB001520 5-hydroxytryptamine 4 receptor signature IPB002233 Adrenergic receptor signature
UniProtKB/Swiss-Prot: 5HT4R_HUMAN, Q13639Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HTR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 5HT4R_HUMAN, Q13639Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteinsthat stimulate adenylate cyclase Genatlas biochemistry entry for HTR4:5-hydroxytryptamine (serotonin) receptor,subtype 4A,and three splice variants 4B,4C,4D,G protein coupled receptorsuperfamily,activating adenylate cyclase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): HTR4 (NM_199453) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
HTR4 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Htr4tm1Comp for HTR4
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Htr4):
HTR4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HTR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Monoamine GPCRs | | | 3 | Signaling by GPCR | | | 4 | Development_Ligand-independent activation of ESR1 and ESR2 | | | 5 | Transcription CREB pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for HTR4
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR4
2  GeneGo (Thomson Reuters) Pathways for HTR4
3  BioSystems Pathways for HTR4
5/8 
Reactome Pathways for HTR4 (see all 8)
1  PharmGKB Pathway for HTR4
2 
Kegg Pathways (Kegg details for HTR4):
HTR4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/66 Interacting proteins for HTR4 (Q136392, 3 ENSP000003539154) via UniProtKB, MINT, STRING, and/or I2D (see all 66)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor signaling pathway |
TAS | 9351641 | | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
TAS | 9603189 | | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway |
-- | -- | | GO:0007210 | serotonin receptor signaling pathway |
TAS | 9603189 | | GO:0007214 | gamma-aminobutyric acid signaling pathway |
-- | -- |
HTR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HTR4 for compounds About GeneDecksing
Compounds for HTR4 available from Tocris Bioscience About this table
1 HMDB Compound for HTR4 About this table
5 DrugBank Compounds for HTR4 About this table
10/28 Novoseek chemical compound relationships for HTR4 gene (see all 28) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tegaserod |
92.5 |
27 |
16817836 (3), 12358251 (2), 11743242 (1), 12946544 (1) (see all 20) |
| gr 113808 |
86.7 |
4 |
19615378 (1), 15007537 (1), 7965722 (1), 15950987 (1) |
| renzapride |
86.4 |
5 |
1600046 (1), 1330164 (1), 18922103 (1), 16696817 (1) |
| cisapride |
86 |
10 |
9506010 (2), 7949460 (1), 10780971 (1), 14501621 (1) (see all 8) |
| mosapride |
83.4 |
8 |
16153398 (2), 16173472 (2), 14501621 (1), 19889470 (1) (see all 6) |
| 5-hydroxytryptamine |
83.2 |
52 |
9862758 (3), 10543288 (2), 8959736 (2), 12358251 (2) (see all 27) |
| tropisetron |
81.6 |
7 |
10543288 (1), 9826103 (1), 1600046 (1), 1330164 (1) (see all 5) |
| 5-methoxytryptamine |
80.8 |
4 |
10543288 (1), 7599849 (1), 12580024 (1), 16702620 (1) |
| methiothepin |
79.4 |
3 |
7599849 (1), 1330164 (1), 16702620 (1) |
| 2-methyl-5-ht |
72.5 |
1 |
10543288 (1) |
Search CenterWatch for drugs/clinical trials and news about HTR4 / 5HT4R
|
Transcripts
for HTR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HTR4 gene (6 alternative transcripts): NM_000870.5 NM_001040169.2 NM_001040172.2 NM_001040173.2 NM_199453.3 NM_001040174.1 Unigene Cluster for HTR4: 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled Hs.483773 [show with all ESTs]Unigene Representative Sequence: AJ13172414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521530 ENST00000522588 ENST00000521735 ENST00000517929(uc021yfi.1)
ENST00000520514(uc011dby.1) ENST00000377888 ENST00000360693(uc021yfj.1)
ENST00000524063 ENST00000521124(uc021yfk.1) ENST00000519495 ENST00000520086(uc003lpq.1)
ENST00000354217(uc021yfh.1) ENST00000314512(uc021yfg.1 uc010jgu.1)
ENST00000362016(uc003lpn.3 uc010jgv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): HTR4 (NM_199453) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR4 |
Additional cDNA sequence: AJ011371.1 AJ131724.1 AJ131725.1 AJ131726.1 AJ278979.1 AJ278980.1 AJ278981.1 AJ278982.1 AJ519673.1 AJ633645.1 AK095223.1 AK308471.1 AM712912.1 BC074755.2 BC095497.1 Y08756.1 Y09586.1 Y10437.1 Y12505.1 Y12506.1 Y12507.1 Y13584.1 Z48150.1 10 DOTS entries: DT.40234835 DT.108819 DT.91661182 DT.102830595 DT.99937173 DT.120832090 DT.95149585 DT.101972406 DT.91661178 DT.95332349 24/113 AceView cDNA sequences (see all 113): AK095223 AJ011371 BM552239 AJ278979 AY341075 AJ131725 AK127050 CR595950 BX386178 AJ633645 BI054444 NM_024577 Z48150 AJ278980 BQ213149 CR608321 AJ519673 CB141690 AJ131726 BF509449 Y13584 BX283793 NM_199453 CF147797
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HTR4 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HTR4
|
Expression
for HTR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGCCTGC
About this image
See HTR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR4
SOURCE GeneReport for Unigene cluster: Hs.483773
UniProtKB/Swiss-Prot: 5HT4R_HUMAN, Q13639Tissue specificity: Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle
SABiosciences Expression via Pathway-Focused PCR Arrays including HTR4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR4 |
Orthologs
for HTR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR4 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HTR41 |
5-hydroxytryptamine (serotonin) receptor 4 |
83(n)
89.8(a) |
|
416150 XM_414481.3 XP_414481.3 |
lizard
(Anolis carolinensis) |
Reptilia |
HTR46-- |
-- |
89(a)32(a) |
1 ↔ 1possible ortholog |
2(121851362-121887518) 6(59608050-59620203) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5590891 |
5-hydroxytryptamine receptor 4-like |
64.96(n)
68.38(a) |
|
559089 XM_682395.1 XP_687487.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG69193
oa21 |
G-protein coupled receptor protein signaling
pathway more3
octopamine receptor 21 |
42(a)
(best of 3)3
53.31(n)1
46.69(a)1 |
|
94B23
426521 NM_001170219.11 NP_001163690.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
dop-46 |
Dopamine receptor 4 |
21(a) |
1 ↔ 1 |
X(1295273-1298653) |
ENSEMBL Gene Tree for HTR4 (if available)
TreeFam Gene Tree for HTR4 (if available) |
Paralogs
for HTR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HTR4 gene
- TAAR62 HTR2A2 HTR62 TAAR22 ADRB12 TAAR82 HRH22 HTR2B2
- DRD12 HTR2C2 TAAR12 ADRB22 DRD52 ADRB32 TAAR52
18/31 SIMAP similar genes for HTR4 using alignment to 4 protein entries: 5HT4R_HUMAN (see all proteins)
(see all similar genes):HTR4B ADORA2A HTR2B DRD2 GHSR HRH2
TAAR1 ADRB2 TAAR2 TAAR3 TAAR5 DRD5P1
TAAR9 hA2aR TAAR6 DRD1 DRD5 GPR85
HTR4 for paralogs About GeneDecksing
|
Genomic Variants
for HTR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HTR4 (147830595 - 148056798 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HTR4
1 CNV: 6454 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR4 |
|
Disorders
/ Diseases
for HTR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR4 for disorders About GeneDecksing
OMIM gene information: 602164
OMIM disorders: --
20/34  diseases for HTR4 (see all 34): About MalaCardsattention deficit hyperactivity disorder heart block atrial fibrillation congenital heart block
irritable bowel syndrome dyspepsia chronic fatigue syndrome adrenal hyperplasia
pulmonary function adrenal adenoma hyperaldosteronism gastroparesis
obstructive lung disease ileus cushing's syndrome adrenocortical tumor
constipation bipolar disorder colon adenocarcinoma diarrhea
5 diseases from the University of Copenhagen DISEASES database for HTR4:Constipation Functional colonic disease Gastroparesis Irritable bowel syndrome
Ileus 8 Novoseek disease relationships for HTR4 gene About this table
Genetic Association Database (GAD): HTR4
Human Genome Epidemiology (HuGE) Navigator: HTR4 (17 documents)
Export disorders for HTR4 gene to outside databases
|
Publications
for HTR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HTR4 gene, integrated from 9 sources (see all 232):
(articles sorted by number of sources associating them with HTR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. (PubMed id 12898568)1, 4, 9 Suzuki T....Ozaki N. (2003)
- Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. (PubMed id 12399948)1, 4, 9 Ohtsuki T....Arinami T. (2002)
- Cloning, expression, and pharmacology of four human 5- hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. (PubMed id 9603189)1, 2, 9 Blondel O.... Fischmeister R. (1998)
- Expression of serotonin receptor mRNAs in blood vessels. (PubMed id 7656980)1, 2, 9 Ullmer C.... Luebbert H. (1995)
- Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i). (PubMed id 15118808)1, 2 Brattelid T.... Levy F.O. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants. (PubMed id 11750916)1, 2 Vilaro M.T.... Mengod G. (2002)
- 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. (PubMed id 11218067)1, 7 Bach T....Levy F.O. (2001)
- Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. (PubMed id 10646498)1, 2 Bender E.... Luyten W. (2000)
- Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. (PubMed id 10220570)1, 2 Claeysen S.... Dumuis A. (1999)
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External Searches for HTR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HTR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HTR4 gene
(According to HUGE)
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Specialized Databases showing HTR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HTR4 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HTR4 gene:
Search GeneIP for patents involving HTR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HTR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for HTR4 | | OriGene shRNA RFP for HTR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR4 | | | OriGene Protein Over-expression Lysate for HTR4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HTR4 | | OriGene 3'-UTR Clone for HTR4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR4 |
|  |  |  | | | | Search ThermoFisher Antibodies for HTR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR4 |
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