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Aliases for HTR4 Gene

Aliases for HTR4 Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 4, G Protein-Coupled 2 3
  • 5-HT4 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 4 2
  • 5-Hydroxytryptamine Receptor 4 3
  • Cardiac 5-HT4 Receptor 3
  • Serotonin Receptor 4 4
  • 5-HT4R 3
  • 5-HT-4 4

External Ids for HTR4 Gene

Previous GeneCards Identifiers for HTR4 Gene

  • GC05M147904
  • GC05M148425
  • GC05M147859
  • GC05M147810
  • GC05M142977

Summaries for HTR4 Gene

Entrez Gene Summary for HTR4 Gene

  • This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

GeneCards Summary for HTR4 Gene

HTR4 (5-Hydroxytryptamine (Serotonin) Receptor 4, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR4 include functional colonic disease and colonic disease. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is TAAR9.

UniProtKB/Swiss-Prot for HTR4 Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Tocris Summary for HTR4 Gene

  • Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation. The human 5-HT4 receptor gene has been localized to chromosome 5 (5q31-33).

Gene Wiki entry for HTR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR4 Gene

Genomics for HTR4 Gene

Regulatory Elements for HTR4 Gene

Genomic Location for HTR4 Gene

148,451,032 bp from pter
148,677,235 bp from pter
226,204 bases
Minus strand

Genomic View for HTR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR4 Gene

Proteins for HTR4 Gene

  • Protein details for HTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 4
    Protein Accession:
    Secondary Accessions:
    • C4WYH4
    • Q546Q1
    • Q684M0
    • Q712M9
    • Q96KH9
    • Q96KI0
    • Q9H199
    • Q9NY73
    • Q9UBM6
    • Q9UBT4
    • Q9UE22
    • Q9UE23
    • Q9UQR6

    Protein attributes for HTR4 Gene

    388 amino acids
    Molecular mass:
    43761 Da
    Quaternary structure:
    • Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).

    Alternative splice isoforms for HTR4 Gene

neXtProt entry for HTR4 Gene

Proteomics data for HTR4 Gene at MOPED

Post-translational modifications for HTR4 Gene

  • Glycosylation at Asn7
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTR4 (5-HT(4))

No data available for DME Specific Peptides for HTR4 Gene

Domains for HTR4 Gene

Suggested Antigen Peptide Sequences for HTR4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR4: view

Function for HTR4 Gene

Molecular function for HTR4 Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 4A,and three splice variants 4B,4C,4D,G protein coupled receptor superfamily,activating adenylate cyclase
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Gene Ontology (GO) - Molecular Function for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001594 NOT trace-amine receptor activity IBA --
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 16102731
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HTR4: view
genes like me logo Genes that share phenotypes with HTR4: view

Animal Models for HTR4 Gene

MGI Knock Outs for HTR4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HTR4 Gene

Localization for HTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR4 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for HTR4 Gene COMPARTMENTS Subcellular localization image for HTR4 gene
Compartment Confidence
endosome 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15925089
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IDA 16102731
genes like me logo Genes that share ontologies with HTR4: view

Pathways for HTR4 Gene

genes like me logo Genes that share pathways with HTR4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9351641
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9603189
GO:0007210 serotonin receptor signaling pathway TAS 9603189
GO:0007214 gamma-aminobutyric acid signaling pathway IBA --
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR4: view

Drugs for HTR4 Gene

(10) Drugbank Compounds for HTR4 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (+-)-Cisapride
81098-60-4 Target agonist approved, investigational, withdrawn
  • 2-Methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide
364-62-5 4168 Target agonist approved, investigational
  • Paxapride
66564-14-5 Target agonist approved
Ergoloid mesylate
  • co-dergocrine mesilate
8067-24-1 Target antagonist approved
  • Zofran odt
99614-02-5 4595 Target agonist approved

(5) Tocris Compounds for HTR4 Gene

Compound Action Cas Number
BIMU 8 Potent 5-HT4 receptor full agonist [134296-40-5]
GR 113808 Potent, selective 5-HT4 antagonist [144625-51-4]
GR 125487 sulfamate Potent, selective 5-HT4 antagonist; active in vivo [859502-43-5]
RS 39604 hydrochloride 5-HT4 antagonist [167710-87-4]
RS 67333 hydrochloride 5-HT4 partial agonist [168986-60-5]

(39) ApexBio Compounds for HTR4 Gene

Compound Action Cas Number
Amitriptyline HCl Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor [549-18-8]
Asenapine Inhibits adrenergic receptor/5-HT receptor [85650-56-2]
Bilobalide Neuroprotective agent [33570-04-6]
Blonanserin Atypical antipsychotic [132810-10-7]
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker [17321-77-6]
Dapoxetine HCl Selective serotonin reuptake inhibitor [129938-20-1]
Desvenlafaxine [93413-62-8]
Desvenlafaxine Succinate [386750-22-7]
Duloxetine HCl [136434-34-9]
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor [219861-08-2]
Fenspiride HCl [5053-8-7]
Fluoxetine HCl Serotonin reuptake inhibitor,selective [56296-78-7]
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant [61718-82-9]
Ketanserin [74050-98-9]
Lorcaserin HCl [846589-98-8]
LY310762 [192927-92-7]
Milnacipran HCl [101152-94-7]
Mosapride Citrate 5-HT receptor agonist [112885-42-4]
Naratriptan [143388-64-1]
Olanzapine [132539-06-1]
Ondansetron [99614-02-5]
Palonosetron HCl [135729-62-3]
Pizotifen Malate [5189-11-7]
Prucalopride Succinat [179474-85-2]
Risperidone SR-2A inhibitor [106266-06-2]
Rizatriptan Benzoate [145202-66-0]
SB271046 [209481-20-9]
SEA0400 Specific inhibitor of Na+/Ca2+ exchange [223104-29-8]
Sertraline HCl [79559-97-0]
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant [30123-17-2]
Trazodone HCl Antidepressant [25332-39-2]
Tropisetron [105826-92-4]
Urapidil HCl [64887-14-5]
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor [99300-78-4]
Vortioxetine 5-HT receptors antagonist [508233-74-7]
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic [960203-27-4]
VUF 10166 [155584-74-0]
Ziprasidone HCl Serotonin and dopamine receptor antagonist [122883-93-6]
Zolmitriptan [139264-17-8]

(4) HMDB Compounds for HTR4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Metaclopramide
  • 3-(2-Aminoethyl)-1H-indol-5-ol

(28) IUPHAR Ligand for HTR4 Gene

Ligand Type Action Affinity Pubmed IDs
RS 100235 Antagonist Antagonist 12.2
GR 125487 Antagonist Antagonist 10.7
piboserod Antagonist Antagonist 10.4
SB 204070 Antagonist Antagonist 10.4
SB 207710 Antagonist Antagonist 10.3
GR 113808 Antagonist Antagonist 10.3
ML 10375 Antagonist Antagonist 10
[3H]GR 113808 Antagonist Antagonist 9.7
RS 116 2617 Antagonist Inverse agonist 9.6
SL65.0155 Agonist Partial agonist 9.2
ML 10302 Agonist Partial agonist 9
SB 203186 Antagonist Antagonist 8.9
RS 67333 Agonist Partial agonist 8.7
RS 39604 Antagonist Antagonist 8.7
[11C]SB207145 Antagonist Antagonist 8.6
prucalopride Agonist Partial agonist 8.6
BIMU 1 Agonist Full agonist 8.4
tegaserod Agonist Partial agonist 8.4
DAU 6285 Antagonist Antagonist 8
cisapride Agonist Partial agonist 7.4
BIMU 8 Agonist Full agonist 7.3
mosapride Agonist Full agonist 6.9
5-MeOT Agonist Full agonist 6.8
renzapride Agonist Full agonist 6.8
zacopride Agonist Full agonist 6.6
alpha-methyl-5-HT Agonist Full agonist 5.8
tropisetron Antagonist Antagonist 4.9
5-HT Inhibitor Inhibition 2.2

(28) Novoseek inferred chemical compound relationships for HTR4 Gene

Compound -log(P) Hits PubMed IDs
tegaserod 92.5 23
gr 113808 86.7 4
renzapride 86.4 4
cisapride 86 9
mosapride 83.4 8
genes like me logo Genes that share compounds with HTR4: view

Transcripts for HTR4 Gene

Unigene Clusters for HTR4 Gene

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: -

Relevant External Links for HTR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR4 Gene

mRNA expression in normal human tissues for HTR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.1), Small Intestine - Terminal Ileum (6.1), Brain - Caudate (basal ganglia) (5.8), Colon - Transverse (5.3), and Brain - Putamen (basal ganglia) (4.0).

SOURCE GeneReport for Unigene cluster for HTR4 Gene Hs.483773

mRNA Expression by UniProt/SwissProt for HTR4 Gene

Tissue specificity: Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
genes like me logo Genes that share expressions with HTR4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for HTR4 Gene

Orthologs for HTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HTR4 35
  • 93.73 (n)
  • 94.85 (a)
HTR4 36
  • 92 (a)
(Canis familiaris)
Mammalia HTR4 35
  • 93.63 (n)
  • 96.63 (a)
HTR4 36
  • 94 (a)
(Mus musculus)
Mammalia Htr4 35
  • 90.89 (n)
  • 93.3 (a)
Htr4 16
Htr4 36
  • 93 (a)
(Pan troglodytes)
Mammalia HTR4 35
  • 99.61 (n)
  • 99.77 (a)
HTR4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Htr4 35
  • 90.56 (n)
  • 92.73 (a)
(Monodelphis domestica)
Mammalia HTR4 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HTR4 36
  • 91 (a)
(Gallus gallus)
Aves HTR4 35
  • 82.6 (n)
  • 88.46 (a)
HTR4 36
  • 89 (a)
(Anolis carolinensis)
Reptilia HTR4 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493952 35
  • 74.52 (n)
  • 83.38 (a)
(Danio rerio)
Actinopterygii LOC556843 35
  • 71.86 (n)
  • 75.32 (a)
HTR4 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6919 37
  • 42 (a)
CG6989 37
  • 36 (a)
DopR 37
  • 35 (a)
oa2 35
  • 54.34 (n)
  • 47.54 (a)
oa2 36
  • 28 (a)
Octbeta2R 36
  • 26 (a)
Species with no ortholog for HTR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR4 Gene

Gene Tree for HTR4 (if available)
Gene Tree for HTR4 (if available)

Paralogs for HTR4 Gene

Paralogs for HTR4 Gene

genes like me logo Genes that share paralogs with HTR4: view

Variants for HTR4 Gene

Sequence variations from dbSNP and Humsavar for HTR4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs723180 -- 148,516,971(-) ATTTC(C/T)TTTGG intron-variant
rs723181 -- 148,516,761(-) CTTTA(A/G)TTAAG intron-variant
rs867279 -- 148,586,456(+) AGTCC(A/G)TTTTC intron-variant
rs10075211 -- 148,459,974(+) aaatg(C/T)taaag intron-variant
rs10073370 -- 148,506,340(+) aactg(G/T)atccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR4 Gene

Variant ID Type Subtype PubMed ID
nsv830516 CNV Loss 17160897
nsv523792 CNV Loss 19592680
esv270273 CNV Insertion 20981092
nsv328933 CNV Loss 16902084

Relevant External Links for HTR4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR4 Gene

Disorders for HTR4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTR4 Gene in MalaCards »

(2) Diseases for HTR4 Gene

(4) University of Copenhagen DISEASES for HTR4 Gene

(8) Novoseek inferred disease relationships for HTR4 Gene

Disease -log(P) Hits PubMed IDs
functional dyspepsia 61.9 2
gastrointestinal diseases 46.7 2
motility disorder 34.2 1
reflux 30.7 2
schizophrenia 7.87 5

Relevant External Links for HTR4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR4: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for HTR4 Gene

Publications for HTR4 Gene

  1. Expression of serotonin receptor mRNAs in blood vessels. (PMID: 7656980) Ullmer C. … Luebbert H. (FEBS Lett. 1995) 3 4 23
  2. Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. (PMID: 12898568) Suzuki T. … Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 23 48
  3. Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. (PMID: 12399948) Ohtsuki T. … Arinami T. (Mol. Psychiatry 2002) 3 23 48
  4. Cloning, expression, and pharmacology of four human 5- hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. (PMID: 9603189) Blondel O. … Fischmeister R. (J. Neurochem. 1998) 3 4 23
  5. 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. (PMID: 11218067) Bach T. … Levy F.O. (Naunyn Schmiedebergs Arch. Pharmacol. 2001) 3 25 26

Products for HTR4 Gene

  • Addgene plasmids for HTR4

Sources for HTR4 Gene

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