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Aliases for HTR3E Gene

Aliases for HTR3E Gene

  • 5-Hydroxytryptamine Receptor 3E 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E 2 3
  • 5-HT3-E 3 4
  • 5-HT3E 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit E 3
  • Serotonin Receptor 3E 4
  • 5-HT3c1 3

External Ids for HTR3E Gene

Previous GeneCards Identifiers for HTR3E Gene

  • GC03P185217
  • GC03P185139
  • GC03P185136
  • GC03P185300
  • GC03P183814
  • GC03P181225

Summaries for HTR3E Gene

Entrez Gene Summary for HTR3E Gene

  • This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

GeneCards Summary for HTR3E Gene

HTR3E (5-Hydroxytryptamine Receptor 3E) is a Protein Coding gene. Diseases associated with HTR3E include irritable bowel syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CREB Pathway. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3E Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3E Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3E Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3E Gene

Genomics for HTR3E Gene

Regulatory Elements for HTR3E Gene

Genomic Location for HTR3E Gene

Chromosome:
3
Start:
184,097,064 bp from pter
End:
184,106,995 bp from pter
Size:
9,932 bases
Orientation:
Plus strand

Genomic View for HTR3E Gene

Genes around HTR3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3E Gene

Proteins for HTR3E Gene

  • Protein details for HTR3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5X5Y0-5HT3E_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3E
    Protein Accession:
    A5X5Y0
    Secondary Accessions:
    • A8IKD7
    • E9PGF1
    • Q495G1
    • Q495G3
    • Q6V706
    • Q6V707
    • Q7Z6B2

    Protein attributes for HTR3E Gene

    Size:
    456 amino acids
    Molecular mass:
    51438 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3E Gene

Proteomics data for HTR3E Gene at MOPED

Post-translational modifications for HTR3E Gene

  • Glycosylation at Asn 175
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HTR3E Gene

Domains & Families for HTR3E Gene

Gene Families for HTR3E Gene

Suggested Antigen Peptide Sequences for HTR3E Gene

Graphical View of Domain Structure for InterPro Entry

A5X5Y0

UniProtKB/Swiss-Prot:

5HT3E_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
genes like me logo Genes that share domains with HTR3E: view

Function for HTR3E Gene

Molecular function for HTR3E Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 G-protein coupled serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005232 serotonin-activated cation-selective channel activity IBA --
GO:0005515 protein binding IPI 17392525
GO:0015464 NOT contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with HTR3E: view
genes like me logo Genes that share phenotypes with HTR3E: view

Animal Model Products

CRISPR Products

miRNA for HTR3E Gene

miRTarBase miRNAs that target HTR3E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTR3E Gene

Localization for HTR3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3E Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3E Gene COMPARTMENTS Subcellular localization image for HTR3E gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for HTR3E Gene

Pathways & Interactions for HTR3E Gene

genes like me logo Genes that share pathways with HTR3E: view

Pathways by source for HTR3E Gene

Gene Ontology (GO) - Biological Process for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007271 NOT synaptic transmission, cholinergic IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3E: view

No data available for SIGNOR curated interactions for HTR3E Gene

Drugs & Compounds for HTR3E Gene

(7) Drugs for HTR3E Gene - From: DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 1839
Ergoloid mesylate Approved Pharma Target, antagonist 0
Dolasetron Approved Pharma antagonist 8
Granisetron Approved, Investigational Pharma antagonist 71
DDP225 Pharma 0

(5) Additional Compounds for HTR3E Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Phenylbiguanide hydrochloride
55-57-2
2-Methyl-5-hydroxytryptamine hydrochloride
845861-49-6
m-Chlorophenylbiguanide hydrochloride
2113-05-5
N-Methylquipazine dimaleate
171205-17-7
Quipazine dimaleate
150323-78-7

(5) Tocris Compounds for HTR3E Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 5-HT3 agonist 55-57-2
2-Methyl-5-hydroxytryptamine hydrochloride 5-HT3 agonist/potent 5-HT6 ligand 845861-49-6
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
N-Methylquipazine dimaleate 5-HT3 agonist 171205-17-7
Quipazine dimaleate 5-HT3 agonist 150323-78-7
genes like me logo Genes that share compounds with HTR3E: view

Transcripts for HTR3E Gene

mRNA/cDNA for HTR3E Gene

(5) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3E Gene

No ASD Table

Relevant External Links for HTR3E Gene

GeneLoc Exon Structure for
HTR3E
ECgene alternative splicing isoforms for
HTR3E

Expression for HTR3E Gene

mRNA expression in normal human tissues for HTR3E Gene

mRNA differential expression in normal tissues according to GTEx for HTR3E Gene

This gene is overexpressed in Colon - Transverse (x24.2) and Small Intestine - Terminal Ileum (x14.5).

SOURCE GeneReport for Unigene cluster for HTR3E Gene Hs.449179

mRNA Expression by UniProt/SwissProt for HTR3E Gene

A5X5Y0-5HT3E_HUMAN
Tissue specificity: Expressed in adult colon and intestine.
genes like me logo Genes that share expression patterns with HTR3E: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR3E Gene

Orthologs for HTR3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR3E 35
  • 82.67 (n)
  • 73.45 (a)
HTR3E 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR3E 35
  • 84.98 (n)
  • 78.68 (a)
HTR3E 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR3E 35
  • 98.79 (n)
  • 98.41 (a)
HTR3E 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733760 35
  • 52.62 (n)
  • 45.76 (a)
zebrafish
(Danio rerio)
Actinopterygii CU207281.1 36
  • 45 (a)
ManyToMany
CU207281.2 36
  • 32 (a)
ManyToMany
Species with no ortholog for HTR3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3E Gene

ENSEMBL:
Gene Tree for HTR3E (if available)
TreeFam:
Gene Tree for HTR3E (if available)

Paralogs for HTR3E Gene

Paralogs for HTR3E Gene

(9) SIMAP similar genes for HTR3E Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HTR3E Gene

genes like me logo Genes that share paralogs with HTR3E: view

Variants for HTR3E Gene

Sequence variations from dbSNP and Humsavar for HTR3E Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7627615 - 184,100,628(+) CCTTC(A/C/G)CGATG reference, missense
rs13324468 - 184,106,610(+) GCCAC(A/G)CGATG reference, missense
rs6443948 -- 184,095,910(+) tccca(A/G)ctact upstream-variant-2KB
rs6443949 -- 184,098,806(+) tggga(C/G)gctga intron-variant, upstream-variant-2KB
rs6443950 -- 184,099,939(+) CAGGC(A/T)CAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR3E Gene

Variant ID Type Subtype PubMed ID
esv2664042 CNV Deletion 23128226

Variation tolerance for HTR3E Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3E Gene

HapMap Linkage Disequilibrium report
HTR3E
Human Gene Mutation Database (HGMD)
HTR3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3E Gene

Disorders for HTR3E Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR3E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
irritable bowel syndrome
  • ibd
- elite association - COSMIC cancer census association via MalaCards
Search HTR3E in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3E

Genetic Association Database (GAD)
HTR3E
Human Genome Epidemiology (HuGE) Navigator
HTR3E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3E
genes like me logo Genes that share disorders with HTR3E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3E Gene

Publications for HTR3E Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4 67
  2. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PMID: 15157181) Peters J.A. … Lambert J.J. (Biochem. Soc. Trans. 2004) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. 5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option. (PMID: 23928294) Lennertz L. … MAPssner R. (Eur Neuropsychopharmacol 2014) 3
  5. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3

Products for HTR3E Gene

Sources for HTR3E Gene

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