Aliases for HTR3E Gene
External Ids for HTR3E Gene
Previous GeneCards Identifiers for HTR3E Gene
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
GeneCards Summary for HTR3E Gene
HTR3E (5-Hydroxytryptamine Receptor 3E) is a Protein Coding gene. Diseases associated with HTR3E include periodic fever, menstrual cycle dependent and irritable bowel syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and CREB Pathway. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for HTR3E Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).