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HTR3E Gene

protein-coding   GIFtS: 56
GCID: GC03P183814

5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic

(Previous names: 5-hydroxytryptamine (serotonin) receptor 3, family member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic1 2     5-HT3c12
5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E1 2     5-Hydroxytryptamine Receptor 3 Subunit E2
5-HT3-E2 3     5-Hydroxytryptamine Receptor 3E2
5-HT3E2 3     Serotonin Receptor 3E3

External Ids:    HGNC: 240051   Entrez Gene: 2852422   Ensembl: ENSG000001860387   OMIM: 6101235   UniProtKB: A5X5Y03   

Export aliases for HTR3E gene to outside databases

Previous GC identifers: GC03P185217 GC03P185139 GC03P185136 GC03P185300 GC03P181225


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR3E Gene:
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a
role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome
3. Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq,
Feb 2012)

GeneCards Summary for HTR3E Gene:
HTR3E (5-hydroxytryptamine (serotonin) receptor 3E, ionotropic) is a protein-coding gene. Diseases associated with HTR3E include irritable bowel syndrome, and sleep apnea. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively
nonselective, ion channel

summary for HTR3E Gene:
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of
4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor
subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric
complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR3E gene promoter:
         Sp1   RREB-1   CUTL1   LCR-F1   MEF-2A   CP2   FOXO4   FOXO1a   aMEF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR3E promoter sequence
   Search Chromatin IP Primers for HTR3E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27

HTR3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR3E gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P183814:  view genomic region     (about GC identifiers)

Start:
183,814,852 bp from pter      End:
183,824,783 bp from pter
Size:
9,932 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 3E precursor  
Size: 456 amino acids; 51438 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Secondary accessions: A8IKD7 E9PGF1 Q495G1 Q495G3 Q6V706 Q6V707 Q7Z6B2
Alternative splicing: 5 isoforms:  A5X5Y0-1   A5X5Y0-2   A5X5Y0-3   A5X5Y0-4   A5X5Y0-6   

Explore the universe of human proteins at neXtProt for HTR3E: NX_A5X5Y0

Explore proteomics data for HTR3E at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn175

  • See HTR3E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243542.1  NP_001243543.1  NP_872395.2  NP_938055.1  NP_938056.1  

    ENSEMBL proteins: 
     ENSP00000401444   ENSP00000401900   ENSP00000335511   ENSP00000391254   ENSP00000395833  
     ENSP00000406050  
    Reactome Protein details: A5X5Y0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTR3: Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT3E
    5-HT3 receptors

    5 InterPro protein domains:
     IPR027361 Acetylcholine_rcpt_TM
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd
     IPR006029 Neurotrans-gated_channel_TM

    Graphical View of Domain Structure for InterPro Entry A5X5Y0

    ProtoNet protein and cluster: A5X5Y0

    UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)
    subfamily. HTR3E sub-subfamily


    HTR3E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT3E_HUMAN, A5X5Y0
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
    which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively
    nonselective, ion channel

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005230extracellular ligand-gated ion channel activity IEA--
         
    HTR3E for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR3E
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    miRTarBase miRNAs that target HTR3E:
    hsa-mir-510-5p (MIRT001979)

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    SwitchGear 3'UTR luciferase reporter plasmidHTR3E 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT3E_HUMAN, A5X5Y0: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic
    reticulum unless complexed with HTR3A
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    HTR3E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR3E About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Circadian entrainment
    Serotonergic synapse0.33
    5Ligand-gated ion channel transport
    Ligand-gated ion channel transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR3E
        Intracellular Calcium Signaling

    1 Reactome Pathway for HTR3E
        Ligand-gated ion channel transport


    1 Kegg Pathway  (Kegg details for HTR3E):
        Serotonergic synapse


    HTR3E for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HTR3E
    Interactions:

        Search GeneGlobe Interaction Network for HTR3E

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HTR3E (ENSP000003355114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR3AENSP000003477544STRING: ENSP00000347754
    HTR3BENSP000002601914STRING: ENSP00000260191
    HTR3CENSP000003226174STRING: ENSP00000322617
    HTR3DENSP000004054094STRING: ENSP00000405409
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006811ion transport ----
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    HTR3E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HTR3E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Zacopride hydrochlorideHighly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist[90182-92-6]
    Ondansetron hydrochlorideSelective 5-HT3 antagonist[103639-04-9]
    Granisetron hydrochloride5-HT3 antagonist[107007-99-8]
    Tropisetron hydrochloridePotent 5-HT3 receptor antagonist; orally active[105826-92-4]
    SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR3E gene (5 alternative transcripts): 
    NM_001256613.1  NM_001256614.1  NM_182589.2  NM_198313.2  NM_198314.2  

    Unigene Cluster for HTR3E:

    5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
    Hs.449179
    Unigene Representative Sequence: DQ644022
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415389(uc010hxq.3 uc003fml.4) ENST00000425359 ENST00000335304(uc003fmm.3 uc003fmn.3 uc010hxr.3)
    ENST00000431041 ENST00000436361 ENST00000440596
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      QuantiFast Probe-based Assays in human, mouse, rat HTR3E

    Additional mRNA sequence: 

    AY159813.2 AY349352.1 AY349353.1 BC101182.1 BC101183.2 BC101184.2 BC101185.2 DQ644022.1 
    EU165354.1 

    1 DOTS entry:

    DT.101978509 

    4 AceView cDNA sequences:

    AY349353 AY349352 NM_182589 AY159813 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR3E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCCCAATC
    HTR3E Expression
    About this image

    HTR3E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR3E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449179

    UniProtKB/Swiss-Prot: 5HT3E_HUMAN, A5X5Y0
    Tissue specificity: Expressed in adult colon and intestine

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HTR3E gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HTR3E1 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 84.98(n)
    78.68(a)
      100856260  XM_003640143.1  XP_003640191.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017337601 uncharacterized LOC101733760 52.62(n)
    45.76(a)
      101733760  XM_004914836.1  XP_004914893.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CU207281.16
    CU207281.26
    Uncharacterized protein
    45(a)
    32(a)
    many ↔ many
    many ↔ many
    22(38280038-38282003) ENSDARG00000075094
    22(38253238-38265090) ENSDARG00000077959


    ENSEMBL Gene Tree for HTR3E (if available)
    TreeFam Gene Tree for HTR3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR3E gene
    HTR3A2  CHRNA102  CHRNA92  HTR3B2  ZACN2  CHRNA72  CHRFAM7A2  HTR3C2  
    HTR3D2  
    9 SIMAP similar genes for HTR3E using alignment to 2 protein entries:     5HT3E_HUMAN (see all proteins):
    HTR3C    HTR3D    HTR3A    HTR3B    CHRNA7-2    CHRNB1
    CHRNA2    CHRNA5    CHRNA6

    HTR3E for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HTR3E
    PGOHUM00000238286


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR3E (see all 346)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413159891,2
    Cuntested1183689993(+) CACTCA/C/TCTGCT 2 S syn10--------
    rs58550151,2
    C--181225681(+) ATATA-/GGGAGC 2 S E fra10--------
    rs730442031,2
    C,F--183682159(+) AGATTC/ATTCCA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1899575491,2
    --183682251(+) ACACCC/TGGTCT 1 -- us2k10--------
    rs2006661171,2
    C--183682355(-) CTTTCA/CAGCAA 1 -- us2k10--------
    rs1452879061,2
    --183682518(+) GAGGTA/GGCTCA 1 -- us2k10--------
    rs1816757351,2
    C--183682542(+) AGCACC/TTGGGA 1 -- us2k10--------
    rs64439491,2
    C,F,A,H--183682548(+) tgggaG/Cgctga 1 -- us2k110Minor allele frequency- C:0.43NA WA CSA EA 257
    rs1487673901,2
    --183682629(+) AAAAAC/TACAAA 1 -- us2k10--------
    rs1871312851,2
    --183682713(+) CTGGGA/TGCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR3E (183814852 - 183824783 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR3E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664042CNV Deletion23128226

    Human Gene Mutation Database (HGMD): HTR3E
    Locus Specific Mutation Databases (LSDB): HTR3E

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR3E
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR3E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610123    OMIM disorders: --

    6 diseases for HTR3E:    
    About MalaCards
    irritable bowel syndrome    sleep apnea    major depressive disorder    diarrhea
    schizophrenia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HTR3E:
    Irritable bowel syndrome

    HTR3E for disorders           About GeneDecksing

    Genetic Association Database (GAD): HTR3E
    Human Genome Epidemiology (HuGE) Navigator: HTR3E (6 documents)

    Export disorders for HTR3E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR3E gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with HTR3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PubMed id 12801637)1, 2, 3 Niesler B.... Rappold G.A. (Gene 2003)
    2. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PubMed id 20021265)1, 4 Goecke T.W....Fasching P.A. (Acta Obstet Gynecol Scand 2010)
    3. Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PubMed id 20602613)1, 4 Hammer C....Niesler B. (Pharmacogenomics 2010)
    4. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1, 4 Larkin E.K....Redline S. (Am. J. Respir. Crit. Care Med. 2010)
    5. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PubMed id 19794330)1, 4 Schuhmacher A....Maier W. (Pharmacogenet. Genomics 2009)
    6. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PubMed id 15157181)1, 3 Peters J.A....Lambert J.J. (Biochem. Soc. Trans. 2004)
    7. A cluster of novel serotonin receptor 3-like genes on human chromosome 3. (PubMed id 14597179)1, 2 Karnovsky A.M.... Roberds S.L. (Gene 2003)
    8. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1  ....Sullivan P.F. (Mol. Psychiatry 2013)
    9. Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. (PubMed id 21192076)1 Kapeller J....Niesler B. (J. Comp. Neurol. 2011)
    10. A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients. (PubMed id 20356718)1 Lennertz L....MAPssner R. (Eur Neuropsychopharmacol 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285242 HGNC: 24005 AceView: HTR3E Ensembl:ENSG00000186038 euGenes: HUgn285242
    ECgene: HTR3E Kegg: 285242 H-InvDB: HTR3E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR3E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR3E gene:
    Search GeneIP for patents involving HTR3E

    GeneCards and IP:
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