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Aliases for HTR3E Gene

Aliases for HTR3E Gene

  • 5-Hydroxytryptamine Receptor 3E 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic 2 3
  • 5-HT3-E 3 4
  • 5-HT3E 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit E 3
  • Serotonin Receptor 3E 4
  • 5-HT3c1 3

External Ids for HTR3E Gene

Previous GeneCards Identifiers for HTR3E Gene

  • GC03P185217
  • GC03P185139
  • GC03P185136
  • GC03P185300
  • GC03P183814
  • GC03P181225

Summaries for HTR3E Gene

Entrez Gene Summary for HTR3E Gene

  • This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

GeneCards Summary for HTR3E Gene

HTR3E (5-Hydroxytryptamine Receptor 3E) is a Protein Coding gene. Diseases associated with HTR3E include Irritable Bowel Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3C.

UniProtKB/Swiss-Prot for HTR3E Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3E Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3E Gene

Additional gene information for HTR3E Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3E Gene

Genomics for HTR3E Gene

Regulatory Elements for HTR3E Gene

Enhancers for HTR3E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H184531 0.3 FANTOM5 4.9 +434.7 434666 0 CHRD THPO LINC01840 EPHB3 LINC02054 EIF4G1 SNORD66 FAM131A HTR3E HTR3D
GH03H184100 0.2 ENCODE 0.7 +4.4 4406 1 HTR3E HTR3E-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR3E on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR3E Gene

Chromosome:
3
Start:
184,097,064 bp from pter
End:
184,106,995 bp from pter
Size:
9,932 bases
Orientation:
Plus strand

Genomic View for HTR3E Gene

Genes around HTR3E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3E Gene

Proteins for HTR3E Gene

  • Protein details for HTR3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5X5Y0-5HT3E_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3E
    Protein Accession:
    A5X5Y0
    Secondary Accessions:
    • A8IKD7
    • E9PGF1
    • Q495G1
    • Q495G3
    • Q6V706
    • Q6V707
    • Q7Z6B2

    Protein attributes for HTR3E Gene

    Size:
    456 amino acids
    Molecular mass:
    51438 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3E Gene

Post-translational modifications for HTR3E Gene

  • Glycosylation at isoforms=2, 3, 4, 6175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HTR3E Gene

Domains & Families for HTR3E Gene

Gene Families for HTR3E Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for HTR3E Gene

Graphical View of Domain Structure for InterPro Entry

A5X5Y0

UniProtKB/Swiss-Prot:

5HT3E_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.
genes like me logo Genes that share domains with HTR3E: view

Function for HTR3E Gene

Molecular function for HTR3E Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0022850 serotonin-gated cation channel activity IDA 17392525
genes like me logo Genes that share ontologies with HTR3E: view
genes like me logo Genes that share phenotypes with HTR3E: view

Animal Model Products

CRISPR Products

miRNA for HTR3E Gene

miRTarBase miRNAs that target HTR3E

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HTR3E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTR3E Gene

Localization for HTR3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3E Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3E gene
Compartment Confidence
plasma membrane 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3E: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HTR3E Gene

Pathways & Interactions for HTR3E Gene

genes like me logo Genes that share pathways with HTR3E: view

Pathways by source for HTR3E Gene

Gene Ontology (GO) - Biological Process for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0034220 ion transmembrane transport TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with HTR3E: view

No data available for SIGNOR curated interactions for HTR3E Gene

Drugs & Compounds for HTR3E Gene

(21) Drugs for HTR3E Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2226
Ergoloid mesylate Approved Pharma Target, antagonist 0
Setiptiline Approved Pharma Target, antagonist Serotonin receptor antagonist 0
Tiapride Approved, Investigational Pharma Target, antagonist 0
Dolasetron Approved Pharma antagonist 9

(1) Additional Compounds for HTR3E Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ondansetron hydrochloride
99614-01-4

(5) Tocris Compounds for HTR3E Gene

Compound Action Cas Number
Dihydroergotamine mesylate Partial alpha agonist. Non-selective 6190-39-2
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
Ondansetron hydrochloride Selective 5-HT3 antagonist 99614-01-4
SR 57227 hydrochloride Potent, selective 5-HT3 agonist 77145-61-0
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(10) ApexBio Compounds for HTR3E Gene

genes like me logo Genes that share compounds with HTR3E: view

Drug Products

Transcripts for HTR3E Gene

mRNA/cDNA for HTR3E Gene

(5) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HTR3E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3E Gene

No ASD Table

Relevant External Links for HTR3E Gene

GeneLoc Exon Structure for
HTR3E
ECgene alternative splicing isoforms for
HTR3E

Expression for HTR3E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR3E Gene

mRNA differential expression in normal tissues according to GTEx for HTR3E Gene

This gene is overexpressed in Colon - Transverse (x24.2) and Small Intestine - Terminal Ileum (x14.5).

NURSA nuclear receptor signaling pathways regulating expression of HTR3E Gene:

HTR3E

SOURCE GeneReport for Unigene cluster for HTR3E Gene:

Hs.449179

mRNA Expression by UniProt/SwissProt for HTR3E Gene:

A5X5Y0-5HT3E_HUMAN
Tissue specificity: Expressed in adult colon and intestine.
genes like me logo Genes that share expression patterns with HTR3E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR3E Gene

Orthologs for HTR3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3E 33 34
  • 98.79 (n)
dog
(Canis familiaris)
Mammalia HTR3E 33 34
  • 84.98 (n)
cow
(Bos Taurus)
Mammalia HTR3E 33 34
  • 82.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
ManyToMany
-- 34
  • 61 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733760 33
  • 52.62 (n)
zebrafish
(Danio rerio)
Actinopterygii CU207281.1 34
  • 45 (a)
ManyToMany
CU207281.2 34
  • 32 (a)
ManyToMany
Species where no ortholog for HTR3E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3E Gene

ENSEMBL:
Gene Tree for HTR3E (if available)
TreeFam:
Gene Tree for HTR3E (if available)

Paralogs for HTR3E Gene

Paralogs for HTR3E Gene

(9) SIMAP similar genes for HTR3E Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HTR3E Gene

genes like me logo Genes that share paralogs with HTR3E: view

Variants for HTR3E Gene

Sequence variations from dbSNP and Humsavar for HTR3E Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000141018 -- 184,095,203(+) AACAA(C/T)AAAAA nc-transcript-variant, upstream-variant-2KB
rs1000190276 -- 184,095,553(+) ACTCA(G/T)TGGAC intron-variant, upstream-variant-2KB
rs1000294597 -- 184,098,053(+) TGCCC(A/G)CCTCC intron-variant
rs1001142534 -- 184,096,535(+) CAAAT(A/G)AGAAC intron-variant, upstream-variant-2KB
rs1001144894 -- 184,106,584(+) CTCAG(C/T)GGAGC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HTR3E Gene

Variant ID Type Subtype PubMed ID
esv2664042 CNV deletion 23128226
esv3598937 CNV loss 21293372

Variation tolerance for HTR3E Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 64.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3E Gene

Human Gene Mutation Database (HGMD)
HTR3E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3E Gene

Disorders for HTR3E Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR3E Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
irritable bowel syndrome
  • ibd
- elite association - COSMIC cancer census association via MalaCards
Search HTR3E in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3E

Genetic Association Database (GAD)
HTR3E
Human Genome Epidemiology (HuGE) Navigator
HTR3E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3E
genes like me logo Genes that share disorders with HTR3E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3E Gene

Publications for HTR3E Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B … Rappold GA (Gene 2003) 2 3 4 60
  2. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke TW … Fasching PA (Acta obstetricia et gynecologica Scandinavica 2010) 3 45 60
  3. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin EK … Redline S (American journal of respiratory and critical care medicine 2010) 3 45 60
  4. Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PMID: 20602613) Hammer C … Niesler B (Pharmacogenomics 2010) 3 45 60
  5. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A … Maier W (Pharmacogenetics and genomics 2009) 3 45 60

Products for HTR3E Gene

Sources for HTR3E Gene

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