Aliases for HTR3E Gene
External Ids for HTR3E Gene
Previous GeneCards Identifiers for HTR3E Gene
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
GeneCards Summary for HTR3E Gene
HTR3E (5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3E include obstructive sleep apnea and irritable bowel syndrome. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for HTR3E Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.