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Aliases for HTR3E Gene

Aliases for HTR3E Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member E 2 3
  • 5-HT3-E 3 4
  • 5-HT3E 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit E 3
  • 5-Hydroxytryptamine Receptor 3E 3
  • Serotonin Receptor 3E 4
  • 5-HT3c1 3

External Ids for HTR3E Gene

Summaries for HTR3E Gene

Entrez Gene Summary for HTR3E Gene

  • This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

GeneCards Summary for HTR3E Gene

HTR3E (5-Hydroxytryptamine (Serotonin) Receptor 3E, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3E include obstructive sleep apnea and irritable bowel syndrome. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3E Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Tocris Summary for HTR3E Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3E Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3E Gene

Genomics for HTR3E Gene

Genomic Location for HTR3E Gene

184,097,064 bp from pter
184,106,995 bp from pter
9,932 bases
Plus strand

Genomic View for HTR3E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3E Gene

Regulatory Elements for HTR3E Gene

Proteins for HTR3E Gene

  • Protein details for HTR3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 3E
    Protein Accession:
    Secondary Accessions:
    • A8IKD7
    • E9PGF1
    • Q495G1
    • Q495G3
    • Q6V706
    • Q6V707
    • Q7Z6B2

    Protein attributes for HTR3E Gene

    456 amino acids
    Molecular mass:
    51438 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3E Gene


neXtProt entry for HTR3E Gene

Proteomics data for HTR3E Gene at MOPED

Post-translational modifications for HTR3E Gene

Other Protein References for HTR3E Gene

No data available for DME Specific Peptides for HTR3E Gene

Domains for HTR3E Gene

Gene Families for HTR3E Gene

  • HTR :5-HT (serotonin) receptors
  • HTR3 :Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic


  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3E sub-subfamily.:
    • A5X5Y0
genes like me logo Genes that share domains with HTR3E: view

Function for HTR3E Gene

Molecular function for HTR3E Gene

UniProtKB/Swiss-Prot Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Gene Ontology (GO) - Molecular Function for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with HTR3E: view

miRNA for HTR3E Gene

miRTarBase miRNAs that target HTR3E

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HTR3E Gene

Localization for HTR3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3E Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

Jensen Localization Image for HTR3E Gene COMPARTMENTS Subcellular localization image for HTR3E gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3E: view

Pathways for HTR3E Gene

genes like me logo Genes that share pathways with HTR3E: view

Pathways by source for HTR3E Gene

1 KEGG pathway for HTR3E Gene

Interacting Proteins for HTR3E Gene

Gene Ontology (GO) - Biological Process for HTR3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007210 serotonin receptor signaling pathway IDA 17392525
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3E: view

Compounds for HTR3E Gene

(5) Tocris Compounds for HTR3E Gene

Compound Action Cas Number
Granisetron hydrochloride 5-HT3 antagonist [107007-99-8]
Ondansetron hydrochloride Selective 5-HT3 antagonist [103639-04-9]
SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]
Tropisetron hydrochloride Potent 5-HT3 receptor antagonist; orally active [105826-92-4]
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist [90182-92-6]
genes like me logo Genes that share compounds with HTR3E: view

Transcripts for HTR3E Gene

mRNA/cDNA for HTR3E Gene

(5) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3E Gene

No ASD Table

Relevant External Links for HTR3E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR3E Gene

mRNA expression in normal human tissues for HTR3E Gene

mRNA differential expression in normal tissues according to GTEx for HTR3E Gene

This gene is overexpressed in Colon - Transverse (24.2) and Small Intestine - Terminal Ileum (14.5).

SOURCE GeneReport for Unigene cluster for HTR3E Gene Hs.449179

mRNA Expression by UniProt/SwissProt for HTR3E Gene

Tissue specificity: Expressed in adult colon and intestine.
genes like me logo Genes that share expressions with HTR3E: view

Orthologs for HTR3E Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR3E 36
  • 98.79 (n)
  • 98.41 (a)
HTR3E 37
  • 95 (a)
(Bos Taurus)
Mammalia HTR3E 36
  • 82.67 (n)
  • 73.45 (a)
HTR3E 37
  • 71 (a)
(Canis familiaris)
Mammalia HTR3E 36
  • 84.98 (n)
  • 78.68 (a)
HTR3E 37
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
-- 37
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733760 36
  • 52.62 (n)
  • 45.76 (a)
(Danio rerio)
Actinopterygii CU207281.1 37
  • 45 (a)
CU207281.2 37
  • 32 (a)
Species with no ortholog for HTR3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3E Gene

Gene Tree for HTR3E (if available)
Gene Tree for HTR3E (if available)

Paralogs for HTR3E Gene

Paralogs for HTR3E Gene

Selected SIMAP similar genes for HTR3E Gene using alignment to 2 proteins: Pseudogenes for HTR3E Gene

genes like me logo Genes that share paralogs with HTR3E: view

Variants for HTR3E Gene

Sequence variations from dbSNP and Humsavar for HTR3E Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4912522 -- 184,102,178(+) GGTAT(C/G)AACgc intron-variant
rs4912523 -- 184,104,407(+) AGAGA(A/G)ATAAG intron-variant
rs4912524 -- 184,105,788(+) CCCAG(C/T)CTCTA synonymous-codon, reference
rs5855015 -- 184,100,434(+) ATATA(-/G)GGAGC intron-variant, frameshift-variant, reference
rs6414506 -- 184,096,056(+) CATAC(C/T)TGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR3E Gene

Variant ID Type Subtype PubMed ID
esv2664042 CNV Deletion 23128226

Relevant External Links for HTR3E Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for HTR3E Gene

(1) University of Copenhagen DISEASES for HTR3E Gene

Relevant External Links for HTR3E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR3E: view

No data available for UniProtKB/Swiss-Prot for HTR3E Gene

Publications for HTR3E Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4
  2. A cluster of novel serotonin receptor 3-like genes on human chromosome 3. (PMID: 14597179) Karnovsky A.M. … Roberds S.L. (Gene 2003) 3 4
  3. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PMID: 15157181) Peters J.A. … Lambert J.J. (Biochem. Soc. Trans. 2004) 2 3
  4. Characterization of the novel human serotonin receptor subunits 5- HT3C, 5-HT3D, and 5-HT3E. (PMID: 17392525) Niesler B. … Bruess M. (Mol. Pharmacol. 2007) 3 4
  5. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A. … Maier W. (Pharmacogenet. Genomics 2009) 3 49

Products for HTR3E Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HTR3E
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3E
    • Block miRNA regulation of HTR3E using miScript Target Protectors

    Sources for HTR3E Gene

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