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Aliases for HTR3D Gene

Aliases for HTR3D Gene

  • 5-Hydroxytryptamine Receptor 3D 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3 Family Member D 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic 2 3
  • Serotonin Receptor 3D 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit D 3
  • Serotonin 5-HT-3D Receptor 3
  • 5-HT3-D 4
  • 5-HT3D 4
  • 5HT3D 3

External Ids for HTR3D Gene

Previous GeneCards Identifiers for HTR3D Gene

  • GC03P185152
  • GC03P185070
  • GC03P185232
  • GC03P183749
  • GC03P181156

Summaries for HTR3D Gene

Entrez Gene Summary for HTR3D Gene

  • The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for HTR3D Gene

HTR3D (5-Hydroxytryptamine Receptor 3D) is a Protein Coding gene. Among its related pathways are Ion channel transport and Ligand-gated ion channel transport. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot for HTR3D Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3D Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3D Gene

Genomics for HTR3D Gene

Regulatory Elements for HTR3D Gene

Enhancers for HTR3D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F184015 1.1 ENCODE 16.5 -14.5 -14542 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 HTR3D ENSG00000271682 ABCC5 LINC02069 HTR3C PARL EIF2B5 AP2M1 ALG3 CAMK2N2
GH03F184298 0.2 ENCODE 16.2 +268.1 268126 2.9 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 HTR3D EHHADH-AS1 ENSG00000271682 PSMD2 LINC02069 EIF2B5 RPS3P3 ABCF3 PARL VWA5B2
GH03F183883 1.2 ENCODE 16.2 -147.2 -147184 2.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 PARL HTR3D ENSG00000271682 YEATS2-AS1 MCCC1-AS1 POLR2H DCUN1D1 LINC02069 ABCC5 MAP6D1
GH03F184655 1.1 Ensembl ENCODE 16.2 +627.0 626965 5.8 HDGF PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS SP3 MAGEF1 EHHADH-AS1 HTR3D EPHB3 LINC01840 LINC02069 FAM131A YEATS2-AS1
GH03F184005 0.9 ENCODE 11.2 -25.2 -25232 1.5 HDAC1 TBP PKNOX1 SIN3A ZBTB40 RFX5 ZNF366 FOS ZNF362 ZBTB2 ABCC5 EEF1A1P8 HTR3D HTR3C PARL RPSAP31 EIF2B5 CAMK2N2 MAP6D1 ABCC5-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HTR3D on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR3D Gene

Chromosome:
3
Start:
184,031,544 bp from pter
End:
184,039,369 bp from pter
Size:
7,826 bases
Orientation:
Plus strand

Genomic View for HTR3D Gene

Genes around HTR3D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3D Gene

Proteins for HTR3D Gene

  • Protein details for HTR3D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q70Z44-5HT3D_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3D
    Protein Accession:
    Q70Z44
    Secondary Accessions:
    • C9J2I6
    • J3QT78
    • Q495N5
    • Q495N6
    • Q7Z6B3

    Protein attributes for HTR3D Gene

    Size:
    454 amino acids
    Molecular mass:
    50191 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

    Alternative splice isoforms for HTR3D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3D Gene

Post-translational modifications for HTR3D Gene

  • Glycosylation at Asn 66
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR3D Gene

No data available for DME Specific Peptides for HTR3D Gene

Domains & Families for HTR3D Gene

Gene Families for HTR3D Gene

Suggested Antigen Peptide Sequences for HTR3D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q70Z44

UniProtKB/Swiss-Prot:

5HT3D_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.
genes like me logo Genes that share domains with HTR3D: view

Function for HTR3D Gene

Molecular function for HTR3D Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 G-protein coupled serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005232 serotonin-activated cation-selective channel activity IBA --
GO:0005515 protein binding IPI 17392525
GO:0015464 NOT contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with HTR3D: view
genes like me logo Genes that share phenotypes with HTR3D: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR3D Gene

Localization for HTR3D Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3D Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3D Gene COMPARTMENTS Subcellular localization image for HTR3D gene
Compartment Confidence
plasma membrane 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 NOT acetylcholine-gated channel complex IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3D: view

Pathways & Interactions for HTR3D Gene

genes like me logo Genes that share pathways with HTR3D: view

Pathways by source for HTR3D Gene

Gene Ontology (GO) - Biological Process for HTR3D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007271 NOT synaptic transmission, cholinergic IBA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3D: view

No data available for SIGNOR curated interactions for HTR3D Gene

Drugs & Compounds for HTR3D Gene

(84) Drugs for HTR3D Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2043
Ergoloid mesylate Approved Pharma Target, antagonist 0
Asenapine Approved Pharma Antagonist Inhibits adrenergic receptor/5-HT receptor 54
Blonanserin Approved Pharma Atypical antipsychotic 0
Cisapride Approved, Investigational, Withdrawn Pharma Partial agonist, Agonist 5

(1) Additional Compounds for HTR3D Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ondansetron hydrochloride
99614-01-4

(5) Tocris Compounds for HTR3D Gene

Compound Action Cas Number
Dihydroergotamine mesylate Partial alpha agonist. Non-selective 6190-39-2
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
Ondansetron hydrochloride Selective 5-HT3 antagonist 99614-01-4
SR 57227 hydrochloride Potent, selective 5-HT3 agonist 77145-61-0
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(76) ApexBio Compounds for HTR3D Gene

Compound Action Cas Number
(±)-MDMA hydrochloride 92279-84-0
1-Phenylbiguanide hydrochloride 55-57-2
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 155106-73-3
2-Methyl-5-hydroxytryptamine hydrochloride 845861-49-6
3-AQC 201216-42-4
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
Cisapride 81098-60-4
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dexfenfluramine hydrochloride 3239-45-0
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Duloxetine HCl 136434-34-9
Eltoprazine hydrochloride 98206-09-8
EMD 386088 hydrochloride 1171123-46-8
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 46611 185259-85-2
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
Methysergide maleate 129-49-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
N-Methylquipazine dimaleate 171205-17-7
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Pizotifen Malate 5189-11-7
Psilocin 520-53-6
Quipazine dimaleate 150323-78-7
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
RS 39604 hydrochloride 167710-87-4
RS 56812 hydrochloride 143339-12-2
RS 67333 hydrochloride 168986-60-5
RU 24969 66611-26-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258719 hydrochloride 1217674-10-6
SB271046 209481-20-9
SDZ 205-557 hydrochloride 1197334-02-3
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
SR 57227 hydrochloride 77145-61-0
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WY 45233 succinate 448904-47-0
Zacopride hydrochloride 101303-98-4
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR3D: view

Transcripts for HTR3D Gene

mRNA/cDNA for HTR3D Gene

(4) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3D Gene

No ASD Table

Relevant External Links for HTR3D Gene

GeneLoc Exon Structure for
HTR3D
ECgene alternative splicing isoforms for
HTR3D

Expression for HTR3D Gene

mRNA expression in normal human tissues for HTR3D Gene

Protein differential expression in normal tissues from HIPED for HTR3D Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR3D Gene



Protein tissue co-expression partners for HTR3D Gene

NURSA nuclear receptor signaling pathways regulating expression of HTR3D Gene:

HTR3D

SOURCE GeneReport for Unigene cluster for HTR3D Gene:

Hs.448004

mRNA Expression by UniProt/SwissProt for HTR3D Gene:

Q70Z44-5HT3D_HUMAN
Tissue specificity: Expressed in liver, as well as fetal and adult colon and kidney.
genes like me logo Genes that share expression patterns with HTR3D: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HTR3D Gene

Orthologs for HTR3D Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3D 35
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR3D 35
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR3D 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207281.1 35
  • 38 (a)
ManyToMany
CU207281.2 35
  • 25 (a)
ManyToMany
Species where no ortholog for HTR3D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3D Gene

ENSEMBL:
Gene Tree for HTR3D (if available)
TreeFam:
Gene Tree for HTR3D (if available)

Paralogs for HTR3D Gene

Paralogs for HTR3D Gene

(2) SIMAP similar genes for HTR3D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR3D: view

Variants for HTR3D Gene

Sequence variations from dbSNP and Humsavar for HTR3D Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000952 -- 184,038,034(-) ACCTG(C/T)GCCTG reference, missense
rs10937159 -- 184,034,513(+) ctgga(A/C)aacag intron-variant, upstream-variant-2KB
rs111457482 -- 184,036,318(+) GCCAA(A/G)TCTGA intron-variant
rs111689452 -- 184,037,070(+) GTTTT(A/G)TTCTT intron-variant
rs111924327 -- 184,034,570(+) GAGAG(C/T)ACATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR3D Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV insertion 18451855

Variation tolerance for HTR3D Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.83; 83.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3D Gene

Disorders for HTR3D Gene

Relevant External Links for HTR3D

Genetic Association Database (GAD)
HTR3D
Human Genome Epidemiology (HuGE) Navigator
HTR3D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3D

No disorders were found for HTR3D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HTR3D Gene

Publications for HTR3D Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4 64
  2. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke T.W. … Fasching P.A. (Acta Obstet Gynecol Scand 2010) 3 46 64
  3. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin E.K. … Redline S. (Am. J. Respir. Crit. Care Med. 2010) 3 46 64
  4. Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PMID: 20602613) Hammer C. … Niesler B. (Pharmacogenomics 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for HTR3D Gene

Sources for HTR3D Gene

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