HTR3D Gene
protein-coding GIFtS: 47
GCID: GC03P183749
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5-hydroxytryptamine (serotonin) receptor 3D, ionotropic(Previous name: 5-hydroxytryptamine (serotonin) receptor 3 family member...)
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Aliases for HTR3D gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 3D, Ionotropic1 2 | | 5HT3D2 | | 5-Hydroxytryptamine (Serotonin) Receptor 3 Family Member D1 2 | | Serotonin 5-HT-3D Receptor2 | | Serotonin Receptor 3D2 3 | | 5-HT3-D3 | | 5-Hydroxytryptamine Receptor 3 Subunit D2 | | 5-HT3D3 | | 5-Hydroxytryptamine Receptor 3D2 | | |
Export aliases for HTR3D gene to outside databasesPrevious GC identifers: GC03P185152 GC03P185070 GC03P185232 GC03P181156 |
Summaries for HTR3D gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HTR3D: The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit Dof the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, amitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, andmigraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genesencoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2009) UniProtKB/Swiss-Prot: 5HT3D_HUMAN, Q70Z44Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel
summary
for HTR3D: Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression. Gene Wiki entry for HTR3D
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Genomic Views for HTR3D gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HTR3D gene promoter: SRF AREB6 SRF (504 AA) CUTL1 FOXL1 Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR3D
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR3D |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27HTR3D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183749: view genomic region
(about GC identifiers)
Start:
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183,749,332 bp from pter |
End:
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183,757,157 bp from pter |
Size:
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7,826 bases |
Orientation:
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plus strand |
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Proteins for HTR3D gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: 5HT3D_HUMAN, Q70Z44 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 3D precursor Size: 454 amino acids; 50191 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmicreticulum unless complexed with HTR3A
Secondary accessions: C9J2I6 J3QT78 Q495N5 Q495N6 Q7Z6B3Alternative splicing: 4 isoforms: Q70Z44-1 Q70Z44-2 Q70Z44-3 Q70Z44-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HTR3D: NX_Q70Z44
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q70Z44 HTR3D Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138615.1 NP_001157118.1 NP_872343.2 ENSEMBL proteins: ENSP00000334315 ENSP00000405409 ENSP00000371929 ENSP00000389268 Reactome Protein details: Q70Z44 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
HTR3D for ontologies About GeneDecksing
HTR3D Antibody Products: Assay Products for HTR3D: |
Protein
Domains / Families for HTR3D gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR3D for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q70Z44ProtoNet protein and cluster: Q70Z44 UniProtKB/Swiss-Prot: 5HT3D_HUMAN, Q70Z44Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)subfamily. HTR3D sub-subfamily |
Function for HTR3D gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: 5HT3D_HUMAN, Q70Z44Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3D (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3D (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3D |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
IEA | -- |
HTR3D for ontologies About GeneDecksing
|
Pathways & Interactions for HTR3D gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Ion channel transport | | | 2 | CREB Pathway | | | 3 | SLC-mediated transmembrane transport | | | 4 | GABA A receptor activation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR3D 3
Reactome Pathways for HTR3D
HTR3D for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTR3D
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for HTR3D (ENSP000004054094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
-- | -- | | GO:0034220 | ion transmembrane transport |
TAS | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
HTR3D for ontologies About GeneDecksing
|
Drugs & Compounds for HTR3D gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for HTR3D available from Tocris Bioscience About this table Search CenterWatch for drugs/clinical trials and news about HTR3D / 5HT3D 
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Transcripts for HTR3D gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HTR3D gene (3 alternative transcripts): NM_001145143.1 NM_001163646.1 NM_182537.2 Unigene Cluster for HTR3D: 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic Hs.448004 Unigene Representative Sequence: NM_0011636464 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334128(uc003fmj.3 uc010hxp.3) ENST00000428798 ENST00000382489(uc011bqu.2 uc011bqv.2) ENST00000453435
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3D (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3D (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): HTR3D (NM_182537) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR3D | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3D  |
Additional cDNA sequence: AJ437318.1 AY159812.2 BC101090.2 BC101091.2 1 DOTS entry: DT.101975891 4 AceView cDNA sequences: NM_182537 AJ437318 BK001746 AY159812 GeneLoc Exon Structure
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Expression for HTR3D gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR3D expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See HTR3D Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.448004 UniProtKB/Swiss-Prot: 5HT3D_HUMAN, Q70Z44Tissue specificity: Expressed in liver, as well as fetal and adult colon and kidney SABiosciences Custom PCR Arrays for HTR3D
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR3D Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTR3D | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR3D | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR3D | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3D |
Orthologs for HTR3D gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR3D gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for HTR3D (if available) TreeFam Gene Tree for HTR3D (if available)  |
Paralogs for HTR3D gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HTR3D gene
- HTR3E2 HTR3A2 HTR3C2 HTR3B2 ZACN2
3 SIMAP similar genes for HTR3D using alignment to 2 protein entries: 5HT3D_HUMAN (see all proteins):HTR3E HTR3C HTR3A
HTR3D for paralogs About GeneDecksing
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Genomic Variants for HTR3D gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for HTR3D (183749332 - 183757157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HTR3D: -- Locus Specific Mutation Databases (LSDB): HTR3D
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR3D |
|
Disorders
/ Diseases for HTR3D gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR3D for disorders About GeneDecksing
OMIM gene information: 610122
OMIM disorders: --
6 diseases for HTR3D: About MalaCardsirritable bowel syndrome migraine sleep apnea apnea neuronitis schizophrenia 1 disease from the University of Copenhagen DISEASES database for HTR3D:Irritable bowel syndrome Human Genome Epidemiology (HuGE) Navigator: HTR3D (9 documents) Export disorders for HTR3D gene to outside databases
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Publications for HTR3D gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HTR3D gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with HTR3D) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PubMed id 12801637)1, 2, 3 Niesler B.... Rappold G.A. (2003)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. (PubMed id 21192076)1 Kapeller J....Niesler B. (2011)
- Two naturally occurring variants of the serotonin rec eptor gene HTR3C are associated with nausea in pregnancy. (PubMed id 20021265)1 Goecke T.W....Fasching P.A. (2010)
- Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PubMed id 20602613)1 Hammer C....Niesler B. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1 Larkin E.K....Redline S. (2010)
- A coding variant of the novel serotonin receptor subu nit 5-HT3E influences sustained attention in schizophrenia patients. (PubMed id 20356718)1 Lennertz L....MAPssner R. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Influence of 5-HT3 receptor subunit genes HTR3A, HTR3 B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophre nia. (PubMed id 19794330)1 Schuhmacher A....Maier W. (2009)
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External Searches for HTR3D gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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|
Genome Databases showing HTR3D gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTR3D gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR3D gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HTR3D | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HTR3D gene: Search GeneIP for patents involving HTR3D
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HTR3D gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | Tocris compounds for HTR3D |
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 | | HTR3D Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3D |
|  |  |  | | | Search ThermoFisher Antibodies for HTR3D |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3D |
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