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Aliases for HTR3C Gene

Aliases for HTR3C Gene

  • 5-Hydroxytryptamine Receptor 3C 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member C 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic 2 3
  • Serotonin Receptor 3C 3 4
  • 5-HT3-C 3 4
  • 5-HT3C 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit C 3

External Ids for HTR3C Gene

Previous GeneCards Identifiers for HTR3C Gene

  • GC00U991163
  • GC03P184765
  • GC03P185172
  • GC03P185092
  • GC03P185093
  • GC03P185253
  • GC03P183770
  • GC03P181178

Summaries for HTR3C Gene

Entrez Gene Summary for HTR3C Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3C Gene

HTR3C (5-Hydroxytryptamine Receptor 3C) is a Protein Coding gene. Diseases associated with HTR3C include Esophagus Adenocarcinoma. Among its related pathways are Ion channel transport and Ligand-gated ion channel transport. GO annotations related to this gene include extracellular ligand-gated ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot for HTR3C Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3C Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3C Gene

Genomics for HTR3C Gene

Regulatory Elements for HTR3C Gene

Enhancers for HTR3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F184022 1.3 FANTOM5 Ensembl ENCODE 12 -30.5 -30547 1.0 JUN ABCC5 HTR3C PARL RPSAP31 EIF2B5 CAMK2N2 ALG3 ECE2 PSMD2 KLHL6
GH03F183975 0.6 ENCODE 10.6 -75.9 -75920 2.7 HDGF ATF1 PKNOX1 ARNT CREB3L1 ZNF121 NCOA1 CREB3 MEF2D MAFF ABCC5 HTR3C PARL RPSAP31 HTR3E-AS1 EIF2B5 EIF4G1 VWA5B2 FAM131A CAMK2N2
GH03F183966 0.2 ENCODE 10.6 -86.5 -86520 0.2 ZNF687 PKNOX1 MNT DPF2 RAD21 ZNF217 SREBF1 E2F1 ZNF316 GATA3 ABCC5-AS1 HTR3C PARL RPSAP31 HTR3E-AS1 EIF2B5 PSMD2 CAMK2N2 PIR62380
GH03F183967 0.6 ENCODE 10.6 -85.1 -85140 0.2 GATA3 RFX1 PKNOX1 FOS FOSL2 ABCC5-AS1 HTR3C PARL RPSAP31 HTR3E-AS1 EIF2B5 PSMD2 CAMK2N2 PIR62380
GH03F184015 1.1 ENCODE 10.5 -36.0 -36045 3.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 HTR3D ENSG00000271682 ABCC5 LINC02069 HTR3C PARL EIF2B5 AP2M1 ALG3 CAMK2N2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HTR3C on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR3C Gene

Chromosome:
3
Start:
184,053,047 bp from pter
End:
184,060,673 bp from pter
Size:
7,627 bases
Orientation:
Plus strand

Genomic View for HTR3C Gene

Genes around HTR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3C Gene

Proteins for HTR3C Gene

  • Protein details for HTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA8-5HT3C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3C
    Protein Accession:
    Q8WXA8
    Secondary Accessions:
    • A2RRR5

    Protein attributes for HTR3C Gene

    Size:
    447 amino acids
    Molecular mass:
    50220 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

neXtProt entry for HTR3C Gene

Post-translational modifications for HTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3C Gene

Domains & Families for HTR3C Gene

Gene Families for HTR3C Gene

Suggested Antigen Peptide Sequences for HTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXA8

UniProtKB/Swiss-Prot:

5HT3C_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
genes like me logo Genes that share domains with HTR3C: view

Function for HTR3C Gene

Molecular function for HTR3C Gene

UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 G-protein coupled serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005232 serotonin-activated cation-selective channel activity IBA --
GO:0005515 protein binding IPI 17392525
GO:0015464 NOT contributes_to acetylcholine receptor activity IBA --
genes like me logo Genes that share ontologies with HTR3C: view
genes like me logo Genes that share phenotypes with HTR3C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR3C Gene

Localization for HTR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3C Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3C Gene COMPARTMENTS Subcellular localization image for HTR3C gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005892 NOT acetylcholine-gated channel complex IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3C: view

Pathways & Interactions for HTR3C Gene

genes like me logo Genes that share pathways with HTR3C: view

Pathways by source for HTR3C Gene

Gene Ontology (GO) - Biological Process for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007271 NOT synaptic transmission, cholinergic IBA --
GO:0034220 ion transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3C: view

No data available for SIGNOR curated interactions for HTR3C Gene

Drugs & Compounds for HTR3C Gene

(25) Drugs for HTR3C Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2043
Granisetron Approved, Investigational Pharma antagonist Serotonin 5-HT3 receptor antagonist 71
Ergoloid mesylate Approved Pharma Target, antagonist 0
Palonosetron Approved, Investigational Pharma 5-HT3 antagonist 85
Tianeptine Approved Pharma 5-HT facilitator 3

(1) Additional Compounds for HTR3C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ondansetron hydrochloride
99614-01-4

(5) Tocris Compounds for HTR3C Gene

Compound Action Cas Number
Dihydroergotamine mesylate Partial alpha agonist. Non-selective 6190-39-2
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
Ondansetron hydrochloride Selective 5-HT3 antagonist 99614-01-4
SR 57227 hydrochloride Potent, selective 5-HT3 agonist 77145-61-0
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(18) ApexBio Compounds for HTR3C Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 155106-73-3
3-AQC 201216-42-4
Alosetron Hydrochloride 5-HT3 receptor antagonist,potent and highly selective 122852-69-1
Azasetron HCl 5-HT3 receptor antagonist 123040-16-4
EMD 386088 hydrochloride 1171123-46-8
Granisetron Serotonin 5-HT3 receptor antagonist 109889-09-0
Granisetron HCl 5-HT3 receptor antagonist 107007-99-8
m-Chlorophenylbiguanide hydrochloride 2113-05-5
N-Methylquipazine dimaleate 171205-17-7
Ondansetron HCl 5-HT3 receptor antagonist 99614-01-4
Palonosetron 5-HT3 antagonist 135729-61-2
Quipazine dimaleate 150323-78-7
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Tianeptine 5-HT facilitator 66981-73-5
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3C: view

Transcripts for HTR3C Gene

mRNA/cDNA for HTR3C Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3C Gene

5-hydroxytryptamine (serotonin) receptor 3C, ionotropic:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3C Gene

No ASD Table

Relevant External Links for HTR3C Gene

GeneLoc Exon Structure for
HTR3C
ECgene alternative splicing isoforms for
HTR3C

Expression for HTR3C Gene

mRNA expression in normal human tissues for HTR3C Gene

mRNA differential expression in normal tissues according to GTEx for HTR3C Gene

This gene is overexpressed in Lung (x33.6).

NURSA nuclear receptor signaling pathways regulating expression of HTR3C Gene:

HTR3C

SOURCE GeneReport for Unigene cluster for HTR3C Gene:

Hs.632579

mRNA Expression by UniProt/SwissProt for HTR3C Gene:

Q8WXA8-5HT3C_HUMAN
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.
genes like me logo Genes that share expression patterns with HTR3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR3C Gene

Orthologs for HTR3C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3C 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia HTR3C 34 35
  • 85.98 (n)
cow
(Bos Taurus)
Mammalia HTR3C 35
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207281.1 35
  • 46 (a)
ManyToMany
CABZ01016332.1 35
  • 32 (a)
ManyToMany
CU207281.2 35
  • 31 (a)
ManyToMany
Species where no ortholog for HTR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3C Gene

ENSEMBL:
Gene Tree for HTR3C (if available)
TreeFam:
Gene Tree for HTR3C (if available)

Paralogs for HTR3C Gene

Paralogs for HTR3C Gene

(4) SIMAP similar genes for HTR3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR3C: view

Variants for HTR3C Gene

Sequence variations from dbSNP and Humsavar for HTR3C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs142791028 A colorectal cancer sample 184,056,279(+) TCATC(A/G)TGGAA reference, missense
rs10561752 -- 184,055,712(+) TCCAT(-/CA)CACAC intron-variant
rs111300826 -- 184,053,651(+) TATAA(C/T)GATGG intron-variant
rs111600908 -- 184,054,974(+) GGCCC(C/T)GTGGT intron-variant
rs111848404 -- 184,058,626(+) CCAGC(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3C Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV insertion 18451855

Variation tolerance for HTR3C Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.68; 94.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3C Gene

Human Gene Mutation Database (HGMD)
HTR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3C Gene

Disorders for HTR3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR3C Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophagus adenocarcinoma
  • adenocarcinoma of esophagus
- elite association - COSMIC cancer census association via MalaCards
Search HTR3C in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3C

Genetic Association Database (GAD)
HTR3C
Human Genome Epidemiology (HuGE) Navigator
HTR3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3C
genes like me logo Genes that share disorders with HTR3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3C Gene

Publications for HTR3C Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4 64
  2. Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (PMID: 20021265) Goecke T.W. … Fasching P.A. (Acta Obstet Gynecol Scand 2010) 3 46 64
  3. A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PMID: 20538960) Larkin E.K. … Redline S. (Am. J. Respir. Crit. Care Med. 2010) 3 46 64
  4. Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia. (PMID: 19794330) Schuhmacher A. … Maier W. (Pharmacogenet. Genomics 2009) 3 46 64
  5. Allelic variants in HTR3C show association with autism. (PMID: 19035560) RehnstrAPm K. … Peltonen L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for HTR3C Gene

Sources for HTR3C Gene

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