Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HTR3C Gene

Aliases for HTR3C Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member C 2 3
  • Serotonin Receptor 3C 3 4
  • 5-HT3-C 3 4
  • 5-HT3C 3 4
  • 5-Hydroxytryptamine Receptor 3 Subunit C 3
  • 5-Hydroxytryptamine Receptor 3C 3

External Ids for HTR3C Gene

Previous GeneCards Identifiers for HTR3C Gene

  • GC00U991163
  • GC03P184765
  • GC03P185172
  • GC03P185092
  • GC03P185093
  • GC03P185253
  • GC03P183770
  • GC03P181178

Summaries for HTR3C Gene

Entrez Gene Summary for HTR3C Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HTR3C Gene

HTR3C (5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3C include obstructive sleep apnea and sleep apnea. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3C Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Tocris Summary for HTR3C Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3C Gene

Genomics for HTR3C Gene

Regulatory Elements for HTR3C Gene

Genomic Location for HTR3C Gene

Start:
184,053,047 bp from pter
End:
184,060,673 bp from pter
Size:
7,627 bases
Orientation:
Plus strand

Genomic View for HTR3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3C Gene

Proteins for HTR3C Gene

  • Protein details for HTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA8-5HT3C_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3C
    Protein Accession:
    Q8WXA8
    Secondary Accessions:
    • A2RRR5

    Protein attributes for HTR3C Gene

    Size:
    447 amino acids
    Molecular mass:
    50220 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

neXtProt entry for HTR3C Gene

Proteomics data for HTR3C Gene at MOPED

Post-translational modifications for HTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR3C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3C Gene

Domains for HTR3C Gene

Gene Families for HTR3C Gene

HGNC:
  • HTR :5-HT (serotonin) receptors
  • HTR3 :Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic
IUPHAR :

Suggested Antigen Peptide Sequences for HTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXA8

UniProtKB/Swiss-Prot:

5HT3C_HUMAN :
  • Q8WXA8
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3C sub-subfamily.
genes like me logo Genes that share domains with HTR3C: view

Function for HTR3C Gene

Molecular function for HTR3C Gene

UniProtKB/Swiss-Prot Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel

Gene Ontology (GO) - Molecular Function for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 serotonin receptor activity IDA 17392525
GO:0005230 extracellular ligand-gated ion channel activity IEA --
genes like me logo Genes that share ontologies with HTR3C: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR3C Gene

Localization for HTR3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3C Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3C Gene COMPARTMENTS Subcellular localization image for HTR3C gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR3C: view

Pathways for HTR3C Gene

genes like me logo Genes that share pathways with HTR3C: view

Pathways by source for HTR3C Gene

1 KEGG pathway for HTR3C Gene

Interacting Proteins for HTR3C Gene

Gene Ontology (GO) - Biological Process for HTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport --
GO:0007210 serotonin receptor signaling pathway IDA 17392525
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with HTR3C: view

Compounds for HTR3C Gene

(5) Tocris Compounds for HTR3C Gene

Compound Action Cas Number
Dexfenfluramine hydrochloride 5-HT re-uptake inhibitor. Also stimulates 5-HT release [3239-45-0]
Granisetron hydrochloride 5-HT3 antagonist [107007-99-8]
Ondansetron hydrochloride Selective 5-HT3 antagonist [99614-01-4]
SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]
Y-25130 hydrochloride Potent, selective 5-HT3 antagonist [123040-16-4]
genes like me logo Genes that share compounds with HTR3C: view

Transcripts for HTR3C Gene

mRNA/cDNA for HTR3C Gene

(3) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3C Gene

5-hydroxytryptamine (serotonin) receptor 3C, ionotropic:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3C Gene

No ASD Table

Relevant External Links for HTR3C Gene

GeneLoc Exon Structure for
HTR3C
ECgene alternative splicing isoforms for
HTR3C

Expression for HTR3C Gene

mRNA expression in normal human tissues for HTR3C Gene

mRNA differential expression in normal tissues according to GTEx for HTR3C Gene

This gene is overexpressed in Lung (33.6).

SOURCE GeneReport for Unigene cluster for HTR3C Gene Hs.632579

mRNA Expression by UniProt/SwissProt for HTR3C Gene

Q8WXA8-5HT3C_HUMAN
Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as well as fetal colon and kidney.
genes like me logo Genes that share expressions with HTR3C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for HTR3C Gene

Orthologs for HTR3C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3C 35
  • 98.88 (n)
  • 98.66 (a)
HTR3C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR3C 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HTR3C 35
  • 85.98 (n)
  • 81.21 (a)
HTR3C 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01016332.1 36
  • 32 (a)
ManyToMany
CU207281.1 36
  • 46 (a)
ManyToMany
CU207281.2 36
  • 31 (a)
ManyToMany
Species with no ortholog for HTR3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3C Gene

ENSEMBL:
Gene Tree for HTR3C (if available)
TreeFam:
Gene Tree for HTR3C (if available)

Paralogs for HTR3C Gene

Paralogs for HTR3C Gene

Selected SIMAP similar genes for HTR3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR3C: view

Variants for HTR3C Gene

Sequence variations from dbSNP and Humsavar for HTR3C Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6443932 -- 184,051,895(+) AGTTT(C/T)TTTTG upstream-variant-2KB
rs6762938 -- 184,055,983(+) ATCTG(C/T)CTGCC intron-variant
rs6766182 -- 184,053,598(+) AAATA(C/T)TATGG intron-variant
rs6766410 - 184,056,974(+) TGTAA(A/C)CTGGA missense, reference
rs6794223 -- 184,058,045(+) CTAAA(A/G)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3C Gene

Variant ID Type Subtype PubMed ID
nsv4145 CNV Insertion 18451855

Relevant External Links for HTR3C Gene

HapMap Linkage Disequilibrium report
HTR3C
Human Gene Mutation Database (HGMD)
HTR3C
Locus Specific Mutation Databases (LSDB)
HTR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3C Gene

Disorders for HTR3C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HTR3C Gene including...

Search for HTR3C Gene in MalaCards »

Relevant External Links for HTR3C

Genetic Association Database (GAD)
HTR3C
Human Genome Epidemiology (HuGE) Navigator
HTR3C
genes like me logo Genes that share disorders with HTR3C: view

No data available for UniProtKB/Swiss-Prot for HTR3C Gene

Publications for HTR3C Gene

  1. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PMID: 12801637) Niesler B. … Rappold G.A. (Gene 2003) 2 3 4
  2. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PMID: 15157181) Peters J.A. … Lambert J.J. (Biochem. Soc. Trans. 2004) 2 3
  3. Characterization of the novel human serotonin receptor subunits 5- HT3C, 5-HT3D, and 5-HT3E. (PMID: 17392525) Niesler B. … Bruess M. (Mol. Pharmacol. 2007) 3 4
  4. Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. (PMID: 18389280) Fasching P.A. … Strick R. (J. Cancer Res. Clin. Oncol. 2008) 3 48
  5. Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy. (PMID: 18681779) Ward M.B. … McKinnon R.A. (Pharmacogenomics 2008) 3 48

Products for HTR3C Gene

Sources for HTR3C Gene

Back to Top

Content