HTR3C Gene
protein-coding GIFtS: 52
GCID: GC03P183770
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5-hydroxytryptamine (serotonin) receptor 3C, ionotropic(Previous names: 5-hydroxytryptamine (serotonin) receptor 3, family member...)
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Aliases for HTR3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 3C, Ionotropic1 2 | | 5-HT3C2 3 | | 5-Hydroxytryptamine (Serotonin) Receptor 3, Family Member C1 2 | | 5-Hydroxytryptamine Receptor 3 Subunit C2 | | Serotonin Receptor 3C2 3 | | 5-Hydroxytryptamine Receptor 3C2 | | 5-HT3-C2 3 | | |
Export aliases for HTR3C gene to outside databasesPrevious GC identifers: GC00U991163 GC03P184765 GC03P185172 GC03P185092 GC03P185093 GC03P185253 GC03P181178 |
Summaries for HTR3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HTR3C: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C ofthe type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, ahormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encodingsubunits C, D and E form a cluster on chromosome 3. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: 5HT3C_HUMAN, Q8WXA8Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel
summary
for HTR3C: Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression. Gene Wiki entry for HTR3C
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Genomic Views for HTR3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HTR3C gene promoter: p53 Sp1 RREB-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 MEF-2A AREB6 CP2 aMEF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR3C
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR3C |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27HTR3C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183770: view genomic region
(about GC identifiers)
Start:
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183,770,835 bp from pter |
End:
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183,778,461 bp from pter |
Size:
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7,627 bases |
Orientation:
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plus strand |
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Proteins for HTR3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: 5HT3C_HUMAN, Q8WXA8 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 3C precursor Size: 447 amino acids; 50220 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmicreticulum unless complexed with HTR3A
Secondary accessions: A2RRR5Explore the universe of human proteins at neXtProt for HTR3C: NX_Q8WXA8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXA8 HTR3C Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_570126.2 ENSEMBL proteins: ENSP00000322617 Reactome Protein details: Q8WXA8 Human Recombinant Protein Products for HTR3C:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HTR3C for ontologies About GeneDecksing
HTR3C Antibody Products: Assay Products for HTR3C: |
Protein
Domains / Families for HTR3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR3C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXA8ProtoNet protein and cluster: Q8WXA8 1 Blocks protein family: IPB006201 Neurotransmitter-gated ion-channel
UniProtKB/Swiss-Prot: 5HT3C_HUMAN, Q8WXA8Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)subfamily. HTR3C sub-subfamily |
Function for HTR3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: 5HT3C_HUMAN, Q8WXA8Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ionchannel Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- | | GO:0005230 | extracellular ligand-gated ion channel activity |
IEA | -- |
HTR3C for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTR3C (NM_130770) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3C |
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Pathways & Interactions for HTR3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Ion channel transport | | | 2 | CREB Pathway | | | 3 | SLC-mediated transmembrane transport | | | 4 | GABA A receptor activation | |
Pathway sources See GeneCards unified pathways Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR3C 3
Reactome Pathways for HTR3C
HTR3C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTR3C
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5 Interacting proteins for HTR3C (ENSP000003226174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0034220 | ion transmembrane transport |
TAS | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
HTR3C for ontologies About GeneDecksing
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Drugs & Compounds for HTR3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for HTR3C available from Tocris Bioscience About this table Search CenterWatch for drugs/clinical trials and news about HTR3C / 5HT3C 
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Transcripts for HTR3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HTR3C gene: NM_130770.2 Unigene Cluster for HTR3C: 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic Hs.632579 [show with all ESTs]Unigene Representative Sequence: AF4592851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000318351(uc003fmk.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTR3C (NM_130770) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR3C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3C  |
Additional cDNA sequence: AF459285.1 BC131799.1 1 DOTS entry: DT.97807706 3 AceView cDNA sequences: NM_130770 AF459285 CD636081 GeneLoc Exon Structure
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Expression for HTR3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR3C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
 About this image See HTR3C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HTR3C
SOURCE GeneReport for Unigene cluster: Hs.632579
UniProtKB/Swiss-Prot: 5HT3C_HUMAN, Q8WXA8Tissue specificity: Expressed in many tissues including adult brain, colon, intestine, lung, muscle and stomach as wellas fetal colon and kidney SABiosciences Custom PCR Arrays for HTR3C
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR3C Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTR3C | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR3C | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR3C | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3C |
Orthologs for HTR3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR3C gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for HTR3C (if available) TreeFam Gene Tree for HTR3C (if available)  |
Paralogs for HTR3C gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HTR3C gene
- HTR3E2 HTR3A2 HTR3D2 HTR3B2 ZACN2
4 SIMAP similar genes for HTR3C using alignment to 1 protein entry: 5HT3C_HUMAN:HTR3E HTR3D HTR3A HTR3B
HTR3C for paralogs About GeneDecksing
|
Genomic Variants for HTR3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for HTR3C (183770835 - 183778461 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HTR3C: -- Human Gene Mutation Database (HGMD): HTR3C
Locus Specific Mutation Databases (LSDB): HTR3C
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR3C |
|
Disorders
/ Diseases for HTR3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR3C for disorders About GeneDecksing
OMIM gene information: 610121
OMIM disorders: --
4 diseases for HTR3C: About MalaCardssleep apnea apnea neuronitis schizophrenia Human Genome Epidemiology (HuGE) Navigator: HTR3C (8 documents) Export disorders for HTR3C gene to outside databases
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Publications for HTR3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HTR3C gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with HTR3C) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. (PubMed id 12801637)1, 2, 3 Niesler B.... Rappold G.A. (2003)
- The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. (PubMed id 15157181)1, 3 Peters J.A....Lambert J.J. (2004)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E. (PubMed id 21192076)1 Kapeller J....Niesler B. (2011)
- Two naturally occurring variants of the serotonin rec eptor gene HTR3C are associated with nausea in pregnancy. (PubMed id 20021265)1 Goecke T.W....Fasching P.A. (2010)
- A coding variant of the novel serotonin receptor subu nit 5-HT3E influences sustained attention in schizophrenia patients. (PubMed id 20356718)1 Lennertz L....MAPssner R. (2010)
- A candidate gene study of obstructive sleep apnea in European Americans and African Americans. (PubMed id 20538960)1 Larkin E.K....Redline S. (2010)
- Allelic variants in HTR3C show association with autis m. (PubMed id 19035560)1 RehnstrAPm K....Peltonen L. (2009)
- Influence of 5-HT3 receptor subunit genes HTR3A, HTR3 B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophre nia. (PubMed id 19794330)1 Schuhmacher A....Maier W. (2009)
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External Searches for HTR3C gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing HTR3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTR3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTR3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HTR3C | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HTR3C gene: Search GeneIP for patents involving HTR3C
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HTR3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for HTR3C | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTR3C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR3C | | OriGene Protein Over-expression Lysate for HTR3C | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for HTR3C | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3C | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Tocris compounds for HTR3C |
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 | | HTR3C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3C |
|  |  |  |  | | | ThermoFisher Antibodies for HTR3C |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3C |
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