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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR3B Gene

protein-coding   GIFtS: 62
GCID: GC11P113775

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic

(Previous name: 5-hydroxytryptamine (serotonin) receptor 3B )
 Explore 19 diseases affiliated with
HTR3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HTR3B    

Aliases
for HTR3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic1 2     5-Hydroxytryptamine 3 Receptor B Subunit2
5-HT3B1 2 3     5-Hydroxytryptamine Receptor 3B2
5-HT3-B2 3     Serotonin-Gated Ion Channel Subunit2
5-Hydroxytryptamine (Serotonin) Receptor 3B1     Serotonin Receptor 3B3

External Ids:    HGNC: 52981   Entrez Gene: 91772   Ensembl: ENSG000001493057   OMIM: 6046545   UniProtKB: O952643   

Export aliases for HTR3B gene to outside databases

Previous GC identifers: GC11P116128 GC11P115287 GC11P113809 GC11P113313 GC11P113280 GC11P109703


Summaries
for HTR3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HTR3B:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of
the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a
hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not
functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional
features of this receptor. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that
functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when
activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion
channel

summary for HTR3B:
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of
4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor
subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric
complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3B


Genomic Views
for HTR3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR3B gene promoter:
         GR   FOXF2   POU3F1   MEF-2A   S8   IRF-2   Pax-3   LHX3a/Lhx3a   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTR3B promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.1

HTR3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR3B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113775:  view genomic region     (about GC identifiers)

Start:
 113,775,399 bp from pter      End:
 113,817,287 bp from pter
Size:
 41,889 bases      Orientation:
 plus strand

Proteins
for HTR3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 3B precursor  
Size: 441 amino acids; 50292 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic
reticulum unless complexed with HTR3A
Miscellaneous: The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared
to that of HTR3A homomers
Secondary accessions: B0YJ23 Q0VJC3
Alternative splicing: 2 isoforms:  O95264-1   O95264-2   

Explore the universe of human proteins at neXtProt for HTR3B: NX_O95264

Post-translational modifications:

  • N-glycosylation required for membrane localization1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95264

    • HTR3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006019.1  
    ENSEMBL proteins: 
     ENSP00000260191   ENSP00000443118   ENSP00000440894  
    Reactome Protein details: O95264
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    Uscn Proteins for HTR3B

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0030424axon ----
    GO:0043025neuronal cell body ----
    GO:0045211postsynaptic membrane IEA--


    HTR3B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HTR3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HTR3B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008134 5HT3_rcpt_B
     IPR008132 5HT3_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd
     IPR006029 Neurotrans-gated_channel_TM

    Graphical View of Domain Structure for InterPro Entry O95264

    ProtoNet protein and cluster: O95264

    3 Blocks protein families:
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008132 5-hydroxytryptamine 3 receptor signature
    IPB008134 5-hydroxytryptamine 3 receptor B subunit signature


    UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)
    subfamily. HTR3B sub-subfamily


    Function
    for HTR3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that
    functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when
    activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion
    channel

         Genatlas biochemistry entry for HTR3B:
    5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and hyppocampus,also
    expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses

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    Gene Editing
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004993serotonin receptor activity IEA--
    GO:0005216ion channel activity TAS9950429
    GO:0005232serotonin-activated cation-selective channel activity IEA--


    HTR3B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HTR3B:
     Cells with protrusions 

    Animal Models:
         1 MGI phenotypic allele for Htr3b (no phenotypes)

    HTR3B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HTR3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    2CREB Pathway
    		Intracellular Calcium Signaling0.50
    3SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50
    4GABA A receptor activation
    		Ligand-gated ion channel transport0.48

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR3B
        Intracellular Calcium Signaling

    3        Reactome Pathways for HTR3B
        Ligand-gated ion channel transport
    Transmembrane transport of small molecules
    Ion channel transport



    HTR3B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR3B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HTR3B (ENSP000002601914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR3AENSP000003477544STRING: ENSP00000347754
    HTR3CENSP000003226174STRING: ENSP00000322617
    HTR3DENSP000004054094STRING: ENSP00000405409
    HTR3EENSP000003355114STRING: ENSP00000335511
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9950429
    GO:0007210serotonin receptor signaling pathway ----
    GO:0007268synaptic transmission TAS9950429
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--


    HTR3B for ontologies           About GeneDecksing



    Drugs & Compounds
    for HTR3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR3B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HTR3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Y-25130 hydrochloride Potent, selective 5-HT3 antagonist [123040-16-4]
    Zacopride hydrochlorideHighly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist[90182-92-6]
    MDL 722225-HT3 antagonist[40796-97-2]
    Granisetron hydrochloride5-HT3 antagonist[107007-99-8]
    Tropisetron hydrochloridePotent 5-HT3 receptor antagonist; orally active[105826-92-4]

    1 HMDB Compound for HTR3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    2 Novoseek chemical compound relationships for HTR3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-hydroxytryptamine 77.6 3 12750374 (1), 17697394 (1), 12775740 (1)
    arginine 13 1 15157181 (1)

    3 PharmGKB related drug/compound annotations for HTR3B gene
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    pravastatinCA  
    simvastatinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about HTR3B / 5HT3B 

    Transcripts
    for HTR3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HTR3B gene: 
    NM_006028.4  

    Unigene Cluster for HTR3B:

    5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
    Hs.241377  [show with all ESTs]
    Unigene Representative Sequence: AF169255
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260191(uc001pok.3 uc001pol.3) ENST00000537778 ENST00000543092


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF080582.1 AF169255.1 AK314268.1 AM293589.1 

    3 DOTS entries:

    DT.120734640  DT.91754303  DT.91754302 

    5 AceView cDNA sequences:

    AF080582 NM_006028 AF169255 BF942819 BF365118 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HTR3B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:        -                                                               
    SP2:                                                  -                     
    SP3:                                                                        


    ECgene alternative splicing isoforms for HTR3B

    Expression
    for HTR3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGTACTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HTR3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeFrontonasal ProcessHead Mesenchyme
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HTR3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR3B

    SOURCE GeneReport for Unigene cluster: Hs.241377

    UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
    Tissue specificity: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the
    amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus,
    prostate, ovary and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including HTR3B: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for HTR3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HTR3B gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5716321 5-hydroxytryptamine receptor 3A-like 58.54(n)
    52.71(a)    		   571632  XM_695237.4  XP_700329.4 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 15(a)
    		 possible ortholog
    		 Group9.3(266661-268793)
    worm
    (Caenorhabditis elegans)    		 Secernentea eat-26
    des-26
    (see all 4)    		 Acetylcholine receptor subunit alpha-type des-2
    (see all 4)    		 18(a)
    14(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 II(14166807-14171573)
    V(11415324-11420274)


    ENSEMBL Gene Tree for HTR3B (if available)
    TreeFam Gene Tree for HTR3B (if available) 

    Paralogs
    for HTR3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR3B gene
    HTR3E2  HTR3A2  HTR3C2  HTR3D2  ZACN2  
    9 SIMAP similar genes for HTR3B using alignment to 11 protein entries:     5HT3B_HUMAN (see all proteins):
    HTR3A    CHRNA10    CHRNA7-2    CHRND    HTR3E    CHRNA2
    HTR3C    CHRNA5    CHRNB3

    HTR3B for paralogs           About GeneDecksing



    Genomic Variants
    for HTR3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/789 NCBI SNPs in HTR3B are shown (see all 789)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs455851401,2
    		C,--113773561(+) TTTCCT/GTAACT 1 -- us2k13Minor allele frequency- G:0.10NS NA 160
    rs1856253641,2
    		--113773599(+) TGTGTG/TTTTGT 1 -- us2k10--------
    rs455283311,2
    		C,--113773603(+) TTTTTG/ATTTTT 1 -- us2k12Minor allele frequency- A:0.05NS NA 40
    rs120990901,2
    		--113773721(+) aagtaG/Cctggg 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs120990871,2
    		C,F,H,--113773742(+) tgcacC/Taccac 1 -- us2k18Minor allele frequency- T:0.03NS EA WA CSA 530
    rs1820500331,2
    		--113773826(+) GGGCTC/TAAGCA 1 -- us2k10--------
    rs1155706701,2
    		--113773868(+) GATTAC/TAGGTA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs107899701,2
    		C,F,A,H,--113773946(+) TGCCAT/CTGTCT 1 -- us2k130Minor allele frequency- C:0.39NS EA NA WA CSA 2813
    rs454925911,2
    		F--113774008(+) TATACC/AGGAAG 1 -- us2k11Minor allele frequency- A:0.15NS 34
    rs1876218201,2
    		--113774215(+) GGCGCC/GATCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR3B (113775399 - 113817287 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HTR3B: --
    Human Gene Mutation Database (HGMD): HTR3B

    Locus Specific Mutation Databases (LSDB): HTR3B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR3B
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR3B

    Disorders / Diseases
    for HTR3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HTR3B for disorders           About GeneDecksing

    OMIM gene information: 604654    OMIM disorders: --

    19 diseases for HTR3B:    About MalaCards
    gilles de la tourette syndrome    attention deficit hyperactivity disorder    major depressive disorder    heroin dependence
    autism spectrum disorder    irritable bowel syndrome    tourette syndrome    sleep apnea
    drug dependence    chronic fatigue syndrome    eating disorder    apnea
    neuronitis    fibromyalgia    adhd    cholesterol
    schizophrenia    prostatitis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for HTR3B:
    Gilles de la Tourette syndrome

    1 Novoseek disease relationship for HTR3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12775740 (1)

    Genetic Association Database (GAD): HTR3B
    Human Genome Epidemiology (HuGE) Navigator: HTR3B (39 documents)

    Export disorders for HTR3B gene to outside databases

    Publications
    for HTR3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR3B gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with HTR3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PubMed id 9950429)1, 2, 3, 9 Davies P.A.... Kirkness E.F. (1999)
    2. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PubMed id 15293096)1, 2, 4, 9 Frank B.... Rappold G. (2004)
    3. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PubMed id 10521471)1, 2, 3, 9 Dubin A.E.... Erlander M.G. (1999)
    4. Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. (PubMed id 15389765)1, 2, 4 Frank B.... Rappold G. (2004)
    5. Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response. (PubMed id 12363396)1, 4, 9 Gutierrez B....Kerwin R.W. (2002)
    6. Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. (PubMed id 12775740)1, 4, 9 Tremblay P.B....Brockmoller J. (2003)
    7. Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. (PubMed id 17010535)1, 2, 9 Tzvetkov M.V.... Brockmoller J. (2007)
    8. Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists. (PubMed id 15115912)1, 4, 9 Kaiser R....Brockmoller J. (2004)
    9. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. (PubMed id 16487942)1, 2 Yamada K....Yoshikawa T. (2006)
    10. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. (PubMed id 14557147)1, 4 Melke J....Eriksson E. (2003)

    External Searches for HTR3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing HTR3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9177 HGNC: 5298 AceView: HTR3B Ensembl:ENSG00000149305 euGenes: HUgn9177
    ECgene: HTR3B H-InvDB: HTR3B

    Other Databases showing HTR3B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HTR3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HTR3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HTR3B gene:
    Search GeneIP for patents involving HTR3B

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