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HTR3B Gene

protein-coding   GIFtS: 63
GCID: GC11P113775

5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic

(Previous name: 5-hydroxytryptamine (serotonin) receptor 3B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic1 2     5-Hydroxytryptamine 3 Receptor B Subunit2
5-HT3-B2 3     5-Hydroxytryptamine Receptor 3B2
5-HT3B2 3     Serotonin-Gated Ion Channel Subunit2
5-Hydroxytryptamine (Serotonin) Receptor 3B1     Serotonin Receptor 3B3

External Ids:    HGNC: 52981   Entrez Gene: 91772   Ensembl: ENSG000001493057   OMIM: 6046545   UniProtKB: O952643   

Export aliases for HTR3B gene to outside databases

Previous GC identifers: GC11P116128 GC11P115287 GC11P113809 GC11P113313 GC11P113280 GC11P109703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR3B Gene:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B
of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a
neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after
activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A)
displays the full functional features of this receptor. (provided by RefSeq, Aug 2011)

GeneCards Summary for HTR3B Gene:
HTR3B (5-hydroxytryptamine (serotonin) receptor 3B, ionotropic) is a protein-coding gene. Diseases associated with HTR3B include gilles de la tourette syndrome, and fibromyalgia. GO annotations related to this gene include serotonin-activated cation-selective channel activity and serotonin receptor activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively
nonselective, ion channel

summary for HTR3B Gene:
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of
4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor
subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric
complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR3B gene promoter:
         GR   FOXF2   POU3F1   MEF-2A   S8   IRF-2   Pax-3   LHX3a/Lhx3a   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR3B promoter sequence
   Search Chromatin IP Primers for HTR3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.1

HTR3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR3B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113775:  view genomic region     (about GC identifiers)

Start:
113,775,399 bp from pter      End:
113,817,287 bp from pter
Size:
41,889 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 3B precursor  
Size: 441 amino acids; 50292 Da
Subunit: Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex
Miscellaneous: The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers
compared to that of HTR3A homomers
Secondary accessions: B0YJ23 Q0VJC3
Alternative splicing: 2 isoforms:  O95264-1   O95264-2   

Explore the universe of human proteins at neXtProt for HTR3B: NX_O95264

Explore proteomics data for HTR3B at MOPED

Post-translational modifications: 

  • N-glycosylation required for membrane localization1
  • Glycosylation2 at Asn52, Asn96, Asn138, Asn168, Asn203, Asn287

  • See HTR3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006019.1  
    ENSEMBL proteins: 
     ENSP00000260191   ENSP00000443118   ENSP00000440894  
    Reactome Protein details: O95264

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTR3: Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT3B
    5-HT3 receptors

    Selected InterPro protein domains (see all 6):
     IPR027361 Acetylcholine_rcpt_TM
     IPR008134 5HT3_rcpt_B
     IPR008132 5HT3_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry O95264

    ProtoNet protein and cluster: O95264

    3 Blocks protein domains:
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008132 5-hydroxytryptamine 3 receptor signature
    IPB008134 5-hydroxytryptamine 3 receptor B subunit signature


    UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)
    subfamily. HTR3B sub-subfamily


    HTR3B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT3B_HUMAN, O95264
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
    which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively
    nonselective, ion channel

         Genatlas biochemistry entry for HTR3B:
    5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and
    hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004993serotonin receptor activity IEA--
    GO:0005216ion channel activity TAS9950429
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005232serotonin-activated cation-selective channel activity IEA--
         
    HTR3B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR3B:
     Cells with protrusions 

         1 MGI phenotypic allele for Htr3b (no phenotypes)

    HTR3B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr3btm1(KOMP)Vlcg for HTR3B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR3B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT3B_HUMAN, O95264: Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic
    reticulum unless complexed with HTR3A
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0045211postsynaptic membrane IEA--

    HTR3B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR3B About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Circadian entrainment
    Serotonergic synapse0.33
    5Ligand-gated ion channel transport
    Ligand-gated ion channel transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR3B
        Intracellular Calcium Signaling

    1 Reactome Pathway for HTR3B
        Ligand-gated ion channel transport


    1 Kegg Pathway  (Kegg details for HTR3B):
        Serotonergic synapse


    HTR3B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HTR3B: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR3B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HTR3B (ENSP000002601914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR3AENSP000003477544STRING: ENSP00000347754
    HTR3CENSP000003226174STRING: ENSP00000322617
    HTR3DENSP000004054094STRING: ENSP00000405409
    HTR3EENSP000003355114STRING: ENSP00000335511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9950429
    GO:0006811ion transport ----
    GO:0006812cation transport TAS9950429
    GO:0007210serotonin receptor signaling pathway ----
    GO:0007268synaptic transmission TAS9950429

    HTR3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HTR3B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Zacopride hydrochlorideHighly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist[90182-92-6]
    Ondansetron hydrochlorideSelective 5-HT3 antagonist[103639-04-9]
    Granisetron hydrochloride5-HT3 antagonist[107007-99-8]
    Tropisetron hydrochloridePotent 5-HT3 receptor antagonist; orally active[105826-92-4]
    SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]

    1 HMDB Compound for HTR3B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    2 Novoseek inferred chemical compound relationships for HTR3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-hydroxytryptamine 77.6 3 12750374 (1), 17697394 (1), 12775740 (1)
    arginine 13 1 15157181 (1)

    3 PharmGKB related drug/compound annotations for HTR3B gene    About this table
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    pravastatinCA  
    simvastatinCA  



    HTR3B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR3B gene: 
    NM_006028.4  

    Unigene Cluster for HTR3B:

    5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
    Hs.241377  [show with all ESTs]
    Unigene Representative Sequence: AF169255
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260191(uc001pok.3 uc001pol.3) ENST00000537778 ENST00000543092

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    Additional mRNA sequence: 

    AF080582.1 AF169255.1 AK314268.1 AM293589.1 

    3 DOTS entries:

    DT.120734640  DT.91754303  DT.91754302 

    5 AceView cDNA sequences:

    NM_006028 AF080582 AF169255 BF942819 BF365118 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HTR3B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:        -                                                               
    SP2:                                                  -                     
    SP3:                                                                        


    ECgene alternative splicing isoforms for HTR3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTACTCT
    HTR3B Expression
    About this image


    HTR3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
    HTR3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.241377

    UniProtKB/Swiss-Prot: 5HT3B_HUMAN, O95264
    Tissue specificity: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the
    amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine,
    uterus, prostate, ovary and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including HTR3B: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HTR3B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr3b1 , 5 5-hydroxytryptamine (serotonin) receptor 3B1, 5 80.11(n)1
    73.73(a)1
      9 (26.54 cM)5
    570141  NM_020274.41  NP_064670.11 
     489350085 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr3b1 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 57.25(n)
    52.16(a)
      100492229  XM_004916511.1  XP_004916568.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5716321 5-hydroxytryptamine receptor 3A-like 57.85(n)
    51.2(a)
      571632  XM_695237.5  XP_700329.5 


    ENSEMBL Gene Tree for HTR3B (if available)
    TreeFam Gene Tree for HTR3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR3B gene
    HTR3E2  HTR3A2  CHRNA102  CHRNA92  ZACN2  CHRNA72  CHRFAM7A2  HTR3C2  
    HTR3D2  
    8 SIMAP similar genes for HTR3B using alignment to 11 protein entries:     5HT3B_HUMAN (see all proteins):
    HTR3A    CHRNA10    CHRNA7-2    HTR3E    CHRNA2    HTR3C
    CHRNA5    CHRNB3

    HTR3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR3B (see all 946)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455851401,2
    C,F--113636903(+) TTTCCT/GTAACT 1 -- us2k13Minor allele frequency- G:0.10NS NA 160
    rs1856253641,2
    --113636941(+) TGTGTG/TTTTGT 1 -- us2k10--------
    rs455283311,2
    C,F--113636945(+) TTTTTG/ATTTTT 1 -- us2k12Minor allele frequency- A:0.05NS NA 40
    rs120990901,2
    C,F--113637063(+) aagtaG/Cctggg 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs120990871,2
    C,F,H--113637084(+) tgcacC/Taccac 1 -- us2k18Minor allele frequency- T:0.03NS EA WA CSA 530
    rs1820500331,2
    --113637168(+) GGGCTC/TAAGCA 1 -- us2k10--------
    rs1155706701,2
    F--113637210(+) GATTAC/TAGGTA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs107899701,2
    C,F,A,H--113637288(+) tgccaT/Ctgtct 1 -- us2k130Minor allele frequency- C:0.39NS EA NA WA CSA 2813
    rs454925911,2
    F--113637350(+) TATACC/AGGAAG 1 -- us2k11Minor allele frequency- A:0.15NS 34
    rs1876218201,2
    --113637557(+) GGCGCC/GATCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR3B (113775399 - 113817287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HTR3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745092CNV Deletion23290073
    esv2675456CNV Deletion23128226
    esv2745091CNV Deletion23290073
    nsv832273CNV Loss17160897

    Human Gene Mutation Database (HGMD): HTR3B
    Locus Specific Mutation Databases (LSDB): HTR3B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR3B
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604654    OMIM disorders: --

    15 diseases for HTR3B:    
    About MalaCards
    gilles de la tourette syndrome    fibromyalgia    heroin dependence    drug dependence
    chronic fatigue syndrome    eating disorder    sleep apnea    major depressive disorder
    irritable bowel syndrome    attention deficit hyperactivity disorder    autism spectrum disorder    schizophrenia
    neuronitis    cerebritis    prostatitis


    HTR3B for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HTR3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 12775740 (1)

    Genetic Association Database (GAD): HTR3B
    Human Genome Epidemiology (HuGE) Navigator: HTR3B (39 documents)

    Export disorders for HTR3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR3B gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with HTR3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PubMed id 9950429)1, 2, 3, 9 Davies P.A.... Kirkness E.F. (Nature 1999)
    2. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PubMed id 15293096)1, 2, 4, 9 Frank B.... Rappold G. (Clin. Rheumatol. 2004)
    3. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PubMed id 10521471)1, 2, 3, 9 Dubin A.E.... Erlander M.G. (J. Biol. Chem. 1999)
    4. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. (PubMed id 16487942)1, 2, 4 Yamada K....Yoshikawa T. (Biol. Psychiatry 2006)
    5. Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients. (PubMed id 15389765)1, 2, 4 Frank B.... Rappold G. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    6. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. (PubMed id 18807291)1, 4, 9 Ji X....Ozaki N. (Nagoya J Med Sci 2008)
    7. Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response. (PubMed id 12363396)1, 4, 9 GutiAcrrez B....Kerwin R.W. (Schizophr. Res. 2002)
    8. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PubMed id 19741568)1, 4, 9 Hammer C....Niesler B. (Pharmacogenet. Genomics 2009)
    9. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. (PubMed id 17697394)1, 4, 9 Tanaka M....Mine K. (Int. J. Neuropsychopharmacol. 2008)
    10. Variations in the 5-hydroxytryptamine type 3B receptor gene as predictors of the efficacy of antiemetic treatment in cancer patients. (PubMed id 12775740)1, 4, 9 Tremblay P.B....Brockmoller J. (J. Clin. Oncol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9177 HGNC: 5298 AceView: HTR3B Ensembl:ENSG00000149305 euGenes: HUgn9177
    ECgene: HTR3B Kegg: 9177 H-InvDB: HTR3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR3B gene:
    Search GeneIP for patents involving HTR3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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