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Aliases for HTR3B Gene

Aliases for HTR3B Gene

  • 5-Hydroxytryptamine Receptor 3B 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic 2 3
  • 5-HT3-B 3 4
  • 5-HT3B 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3B 2
  • 5-Hydroxytryptamine 3 Receptor B Subunit 3
  • Serotonin-Gated Ion Channel Subunit 3
  • Serotonin Receptor 3B 4

External Ids for HTR3B Gene

Previous GeneCards Identifiers for HTR3B Gene

  • GC11P116128
  • GC11P115287
  • GC11P113809
  • GC11P113313
  • GC11P113280
  • GC11P109703
  • GC11P113775

Summaries for HTR3B Gene

Entrez Gene Summary for HTR3B Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

GeneCards Summary for HTR3B Gene

HTR3B (5-Hydroxytryptamine Receptor 3B) is a Protein Coding gene. Diseases associated with HTR3B include Gilles De La Tourette Syndrome. Among its related pathways are Ion channel transport and Ligand-gated ion channel transport. GO annotations related to this gene include ion channel activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3B Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3B Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).

Gene Wiki entry for HTR3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3B Gene

Genomics for HTR3B Gene

Regulatory Elements for HTR3B Gene

Enhancers for HTR3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F113895 0.9 Ensembl ENCODE 0.8 -2.6 -2594 0.8 CTCF ZNF362 ZNF654 REST RAD21 OSR2 SMC3 ZBTB20 ZNF18 TRIM28 NNMT RNU6-1107P HTR3A ATF4P4 DRD2 HTR3B USP28
GH11F113896 0.6 ENCODE 0.8 -3.3 -3330 0.2 OSR2 CTBP1 SMARCA4 FEZF1 TCF7L2 ZBTB20 TRIM28 NNMT RNU6-1107P HTR3A HTR3B USP28
GH11F113905 0.9 ENCODE 0.4 +7.5 7548 1.7 PKNOX1 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZEB1 ZNF366 SCRT2 ZNF391 USP28 HTR3A RNU6-1107P HTR3B
GH11F113884 0.8 ENCODE 0.4 -14.3 -14332 1.1 TFAP4 TEAD4 ZNF384 CEBPG ZNF48 ZNF644 TEAD3 IRF9 PATZ1 PRDM10 USP28 HTR3B
GH11F113881 0.6 ENCODE 0.3 -16.9 -16890 0.2 ARID1B PKNOX1 JUND ATF3 PBX2 IKZF1 USP28 HTR3B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR3B on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR3B Gene

Chromosome:
11
Start:
113,898,923 bp from pter
End:
113,946,565 bp from pter
Size:
47,643 bases
Orientation:
Plus strand

Genomic View for HTR3B Gene

Genes around HTR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3B Gene

Proteins for HTR3B Gene

  • Protein details for HTR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95264-5HT3B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3B
    Protein Accession:
    O95264
    Secondary Accessions:
    • B0YJ23
    • Q0VJC3

    Protein attributes for HTR3B Gene

    Size:
    441 amino acids
    Molecular mass:
    50292 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
    Miscellaneous:
    • The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers.

    Alternative splice isoforms for HTR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3B Gene

Post-translational modifications for HTR3B Gene

Other Protein References for HTR3B Gene

No data available for DME Specific Peptides for HTR3B Gene

Domains & Families for HTR3B Gene

Gene Families for HTR3B Gene

Graphical View of Domain Structure for InterPro Entry

O95264

UniProtKB/Swiss-Prot:

5HT3B_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
genes like me logo Genes that share domains with HTR3B: view

Function for HTR3B Gene

Molecular function for HTR3B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
UniProtKB/Swiss-Prot Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005232 serotonin-activated cation-selective channel activity IGI 9950429
GO:0015276 ligand-gated ion channel activity IEA --
GO:0015464 NOT contributes_to acetylcholine receptor activity IBA --
GO:0042166 NOT acetylcholine binding IBA --
genes like me logo Genes that share ontologies with HTR3B: view
genes like me logo Genes that share phenotypes with HTR3B: view

Animal Models for HTR3B Gene

MGI Knock Outs for HTR3B:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR3B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR3B Gene

Localization for HTR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3B Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR3B gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005892 NOT acetylcholine-gated channel complex IBA --
GO:0009986 cell surface IDA 16571125
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HTR3B: view

Pathways & Interactions for HTR3B Gene

genes like me logo Genes that share pathways with HTR3B: view

Pathways by source for HTR3B Gene

Gene Ontology (GO) - Biological Process for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0007271 NOT synaptic transmission, cholinergic IBA --
GO:0034220 ion transmembrane transport IEA,TAS --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with HTR3B: view

No data available for SIGNOR curated interactions for HTR3B Gene

Drugs & Compounds for HTR3B Gene

(33) Drugs for HTR3B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target 2043
Granisetron Approved, Investigational Pharma antagonist Serotonin 5-HT3 receptor antagonist 71
Ergoloid mesylate Approved Pharma Target, antagonist 0
atorvastatin Approved Pharma Competitive, Inhibitor 0
Paroxetine Approved, Investigational Pharma Inhibition, Inhibitor 226

(1) Additional Compounds for HTR3B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ondansetron hydrochloride
99614-01-4

(5) Tocris Compounds for HTR3B Gene

Compound Action Cas Number
Dihydroergotamine mesylate Partial alpha agonist. Non-selective 6190-39-2
m-Chlorophenylbiguanide hydrochloride Potent and specific 5-HT3 agonist 2113-05-5
Ondansetron hydrochloride Selective 5-HT3 antagonist 99614-01-4
SR 57227 hydrochloride Potent, selective 5-HT3 agonist 77145-61-0
Zacopride hydrochloride Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist 101303-98-4

(18) ApexBio Compounds for HTR3B Gene

Compound Action Cas Number
1-Phenylbiguanide hydrochloride 55-57-2
2-[1-(4-Piperonyl)piperazinyl]benzothiazole 155106-73-3
3-AQC 201216-42-4
Alosetron Hydrochloride 5-HT3 receptor antagonist,potent and highly selective 122852-69-1
Azasetron HCl 5-HT3 receptor antagonist 123040-16-4
EMD 386088 hydrochloride 1171123-46-8
Granisetron Serotonin 5-HT3 receptor antagonist 109889-09-0
Granisetron HCl 5-HT3 receptor antagonist 107007-99-8
m-Chlorophenylbiguanide hydrochloride 2113-05-5
N-Methylquipazine dimaleate 171205-17-7
Ondansetron HCl 5-HT3 receptor antagonist 99614-01-4
Palonosetron 5-HT3 antagonist 135729-61-2
Quipazine dimaleate 150323-78-7
RS 56812 hydrochloride 143339-12-2
SDZ 205-557 hydrochloride 1197334-02-3
SR 57227 hydrochloride 77145-61-0
Tianeptine 5-HT facilitator 66981-73-5
Zacopride hydrochloride 101303-98-4
genes like me logo Genes that share compounds with HTR3B: view

Transcripts for HTR3B Gene

mRNA/cDNA for HTR3B Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3B Gene

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: -
SP3:

Relevant External Links for HTR3B Gene

GeneLoc Exon Structure for
HTR3B
ECgene alternative splicing isoforms for
HTR3B

Expression for HTR3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR3B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x16.5), Brain - Cortex (x14.2), and Brain - Anterior cingulate cortex (BA24) (x9.4).

Protein differential expression in normal tissues from HIPED for HTR3B Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR3B Gene



Protein tissue co-expression partners for HTR3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTR3B Gene:

HTR3B

SOURCE GeneReport for Unigene cluster for HTR3B Gene:

Hs.241377

mRNA Expression by UniProt/SwissProt for HTR3B Gene:

O95264-5HT3B_HUMAN
Tissue specificity: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
genes like me logo Genes that share expression patterns with HTR3B: view

Primer Products

Orthologs for HTR3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3B 34 35
  • 99.17 (n)
cow
(Bos Taurus)
Mammalia HTR3B 34 35
  • 84.44 (n)
dog
(Canis familiaris)
Mammalia HTR3B 34 35
  • 84.18 (n)
mouse
(Mus musculus)
Mammalia Htr3b 34 16 35
  • 80.11 (n)
rat
(Rattus norvegicus)
Mammalia Htr3b 34
  • 79.95 (n)
oppossum
(Monodelphis domestica)
Mammalia HTR3B 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR3B 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr3b 34
  • 57.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC571632 34
  • 57.85 (n)
htr3b 35
  • 47 (a)
OneToOne
Species where no ortholog for HTR3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3B Gene

ENSEMBL:
Gene Tree for HTR3B (if available)
TreeFam:
Gene Tree for HTR3B (if available)

Paralogs for HTR3B Gene

Paralogs for HTR3B Gene

genes like me logo Genes that share paralogs with HTR3B: view

Variants for HTR3B Gene

Sequence variations from dbSNP and Humsavar for HTR3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10502180 -- 113,907,040(+) AACAC(G/T)TTAAG intron-variant, upstream-variant-2KB
rs1077683 -- 113,935,320(+) GCAGG(C/T)GCAAT intron-variant
rs10789970 -- 113,903,224(+) tgcca(C/T)tgtct upstream-variant-2KB
rs10891606 -- 113,910,529(+) TTTGC(C/G)TCCCC intron-variant
rs111282234 -- 113,930,619(+) AAGTA(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR3B Gene

Variant ID Type Subtype PubMed ID
dgv724n106 CNV deletion 24896259
esv2675456 CNV deletion 23128226
esv2745091 CNV deletion 23290073
esv2745092 CNV deletion 23290073
esv3548363 CNV deletion 23714750
nsv1070069 CNV deletion 25765185
nsv1125534 CNV tandem duplication 24896259
nsv832273 CNV loss 17160897

Variation tolerance for HTR3B Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.90; 87.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR3B Gene

Human Gene Mutation Database (HGMD)
HTR3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3B Gene

Disorders for HTR3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gilles de la tourette syndrome
  • tourette syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HTR3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR3B

Genetic Association Database (GAD)
HTR3B
Human Genome Epidemiology (HuGE) Navigator
HTR3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR3B
genes like me logo Genes that share disorders with HTR3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR3B Gene

Publications for HTR3B Gene

  1. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PMID: 15293096) Frank B. … Rappold G. (Clin. Rheumatol. 2004) 3 4 22 46 64
  2. The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PMID: 9950429) Davies P.A. … Kirkness E.F. (Nature 1999) 2 3 4 22 64
  3. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PMID: 10521471) Dubin A.E. … Erlander M.G. (J. Biol. Chem. 1999) 2 3 4 22 64
  4. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PMID: 19741568) Hammer C. … Niesler B. (Pharmacogenet. Genomics 2009) 3 22 46 64
  5. Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea. (PMID: 17697394) Tanaka M. … Mine K. (Int. J. Neuropsychopharmacol. 2008) 3 22 46 64

Products for HTR3B Gene

Sources for HTR3B Gene

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