Aliases for HTR3B Gene
External Ids for HTR3B Gene
Previous GeneCards Identifiers for HTR3B Gene
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
GeneCards Summary for HTR3B Gene
HTR3B (5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3B include gilles de la tourette syndrome and fibromyalgia. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include serotonin receptor activity and serotonin-activated cation-selective channel activity. An important paralog of this gene is HTR3A.
UniProtKB/Swiss-Prot for HTR3B Gene
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.