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Aliases for HTR3B Gene

Aliases for HTR3B Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic 2 3
  • 5-HT3-B 3 4
  • 5-HT3B 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 3B 2
  • 5-Hydroxytryptamine 3 Receptor B Subunit 3
  • Serotonin-Gated Ion Channel Subunit 3
  • 5-Hydroxytryptamine Receptor 3B 3
  • Serotonin Receptor 3B 4

External Ids for HTR3B Gene

Previous GeneCards Identifiers for HTR3B Gene

  • GC11P116128
  • GC11P115287
  • GC11P113809
  • GC11P113313
  • GC11P113280
  • GC11P109703
  • GC11P113775

Summaries for HTR3B Gene

Entrez Gene Summary for HTR3B Gene

  • The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

GeneCards Summary for HTR3B Gene

HTR3B (5-Hydroxytryptamine (Serotonin) Receptor 3B, Ionotropic) is a Protein Coding gene. Diseases associated with HTR3B include gilles de la tourette syndrome and fibromyalgia. Among its related pathways are CREB Pathway and Circadian entrainment. GO annotations related to this gene include serotonin receptor activity and serotonin-activated cation-selective channel activity. An important paralog of this gene is HTR3A.

UniProtKB/Swiss-Prot for HTR3B Gene

  • This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Tocris Summary for HTR3B Gene

  • Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR3B Gene

Genomics for HTR3B Gene

Regulatory Elements for HTR3B Gene

Genomic Location for HTR3B Gene

Start:
113,904,677 bp from pter
End:
113,946,565 bp from pter
Size:
41,889 bases
Orientation:
Plus strand

Genomic View for HTR3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR3B Gene

Proteins for HTR3B Gene

  • Protein details for HTR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95264-5HT3B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 3B
    Protein Accession:
    O95264
    Secondary Accessions:
    • B0YJ23
    • Q0VJC3

    Protein attributes for HTR3B Gene

    Size:
    441 amino acids
    Molecular mass:
    50292 Da
    Quaternary structure:
    • Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
    Miscellaneous:
    • The HA-stretch region of HTR3B seems to confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers

    Alternative splice isoforms for HTR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR3B Gene

Proteomics data for HTR3B Gene at MOPED

Post-translational modifications for HTR3B Gene

  • N-glycosylation required for membrane localization.
  • Glycosylation at Asn52, Asn96, Asn138, Asn168, Asn203, and Asn287
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR3B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR3B Gene

Domains for HTR3B Gene

Gene Families for HTR3B Gene

HGNC:
  • HTR :5-HT (serotonin) receptors
  • HTR3 :Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

O95264

UniProtKB/Swiss-Prot:

5HT3B_HUMAN :
  • O95264
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.
genes like me logo Genes that share domains with HTR3B: view

Function for HTR3B Gene

Molecular function for HTR3B Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype 3b,coexpressed with HTR3A in the amygdala,caudate and hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
UniProtKB/Swiss-Prot Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Gene Ontology (GO) - Molecular Function for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004993 serotonin receptor activity IEA --
GO:0005216 ion channel activity TAS 9950429
GO:0005230 extracellular ligand-gated ion channel activity --
GO:0005232 serotonin-activated cation-selective channel activity IEA --
genes like me logo Genes that share ontologies with HTR3B: view

Phenotypes for HTR3B Gene

GenomeRNAi human phenotypes for HTR3B:
genes like me logo Genes that share phenotypes with HTR3B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR3B Gene

Localization for HTR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR3B Gene

Cell membrane; Multi-pass membrane protein. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR3B Gene COMPARTMENTS Subcellular localization image for HTR3B gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009986 cell surface IDA 16571125
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR3B: view

Pathways for HTR3B Gene

genes like me logo Genes that share pathways with HTR3B: view

Pathways by source for HTR3B Gene

1 KEGG pathway for HTR3B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for HTR3B Gene

Gene Ontology (GO) - Biological Process for HTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9950429
GO:0006811 ion transport --
GO:0006812 cation transport --
GO:0007210 serotonin receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS 9950429
genes like me logo Genes that share ontologies with HTR3B: view

Compounds for HTR3B Gene

(5) Tocris Compounds for HTR3B Gene

Compound Action Cas Number
Dexfenfluramine hydrochloride 5-HT re-uptake inhibitor. Also stimulates 5-HT release [3239-45-0]
Granisetron hydrochloride 5-HT3 antagonist [107007-99-8]
Ondansetron hydrochloride Selective 5-HT3 antagonist [99614-01-4]
SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]
Y-25130 hydrochloride Potent, selective 5-HT3 antagonist [123040-16-4]

(1) HMDB Compounds for HTR3B Gene

Compound Synonyms Cas Number PubMed IDs
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9

(2) Novoseek inferred chemical compound relationships for HTR3B Gene

Compound -log(P) Hits PubMed IDs
5-hydroxytryptamine 77.6 3
arginine 13 1

(3) PharmGKB related drug/compound annotations for HTR3B Gene

Drug/compound Annotation
atorvastatin CA
pravastatin CA
simvastatin CA
genes like me logo Genes that share compounds with HTR3B: view

Transcripts for HTR3B Gene

mRNA/cDNA for HTR3B Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR3B Gene

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR3B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HTR3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR3B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: -
SP3:

Relevant External Links for HTR3B Gene

GeneLoc Exon Structure for
HTR3B
ECgene alternative splicing isoforms for
HTR3B

Expression for HTR3B Gene

mRNA expression in normal human tissues for HTR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTR3B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (16.5), Brain - Cortex (14.2), and Brain - Anterior cingulate cortex (BA24) (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR3B Gene

SOURCE GeneReport for Unigene cluster for HTR3B Gene Hs.241377

mRNA Expression by UniProt/SwissProt for HTR3B Gene

O95264-5HT3B_HUMAN
Tissue specificity: Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta.
genes like me logo Genes that share expressions with HTR3B: view

In Situ Assay Products

Orthologs for HTR3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HTR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR3B 35
  • 99.17 (n)
  • 98.64 (a)
HTR3B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR3B 35
  • 84.44 (n)
  • 78.62 (a)
HTR3B 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR3B 35
  • 84.18 (n)
  • 77.65 (a)
HTR3B 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr3b 35
  • 80.11 (n)
  • 73.73 (a)
Htr3b 16
Htr3b 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTR3B 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR3B 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr3b 35
  • 79.95 (n)
  • 73.04 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia htr3b 35
  • 57.25 (n)
  • 52.16 (a)
zebrafish
(Danio rerio)
Actinopterygii htr3b 36
  • 47 (a)
OneToOne
LOC571632 35
  • 57.85 (n)
  • 51.2 (a)
Species with no ortholog for HTR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTR3B Gene

ENSEMBL:
Gene Tree for HTR3B (if available)
TreeFam:
Gene Tree for HTR3B (if available)

Paralogs for HTR3B Gene

Paralogs for HTR3B Gene

genes like me logo Genes that share paralogs with HTR3B: view

Variants for HTR3B Gene

Sequence variations from dbSNP and Humsavar for HTR3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1077683 -- 113,935,320(+) GCAGG(C/T)GCAAT intron-variant
rs1176730 -- 113,912,397(-) gcgtc(A/G)tggca intron-variant
rs1176731 -- 113,911,619(-) tcccc(A/G)ggagg intron-variant
rs1176732 -- 113,911,474(-) ggtgg(A/G)cagat intron-variant
rs1176733 -- 113,903,764(-) ggttt(G/T)cagta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR3B Gene

Variant ID Type Subtype PubMed ID
nsv832273 CNV Loss 17160897
esv2745091 CNV Deletion 23290073
esv2675456 CNV Deletion 23128226
esv2745092 CNV Deletion 23290073

Relevant External Links for HTR3B Gene

HapMap Linkage Disequilibrium report
HTR3B
Human Gene Mutation Database (HGMD)
HTR3B
Locus Specific Mutation Databases (LSDB)
HTR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR3B Gene

Disorders for HTR3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HTR3B Gene including...

Search for HTR3B Gene in MalaCards »

(1) Novoseek inferred disease relationships for HTR3B Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for HTR3B

Genetic Association Database (GAD)
HTR3B
Human Genome Epidemiology (HuGE) Navigator
HTR3B
genes like me logo Genes that share disorders with HTR3B: view

No data available for UniProtKB/Swiss-Prot for HTR3B Gene

Publications for HTR3B Gene

  1. The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PMID: 9950429) Davies P.A. … Kirkness E.F. (Nature 1999) 2 3 4 23
  2. The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. (PMID: 10521471) Dubin A.E. … Erlander M.G. (J. Biol. Chem. 1999) 2 3 4 23
  3. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PMID: 15293096) Frank B. … Rappold G. (Clin. Rheumatol. 2004) 3 4 23 48
  4. Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. (PMID: 17010535) Tzvetkov M.V. … Brockmoller J. (Gene 2007) 3 4 23
  5. An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population. (PMID: 18807291) Ji X. … Ozaki N. (Nagoya J Med Sci 2008) 3 23 48

Products for HTR3B Gene

Sources for HTR3B Gene

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