HTR3A Gene
protein-coding GIFtS: 65
GCID: GC11P113879
|
|
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic(Previous name: 5-hydroxytryptamine (serotonin) receptor 3A )
(Previous symbol: HTR3)
| |
Aliases
for HTR3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic1 2 | | 5-HT3-A2 3 | | HTR31 2 3 5 | | 5-Hydroxytryptamine Receptor 32 3 | | 5-HT3A1 2 3 | | 5HT3R2 3 | | 5-HT3R1 2 3 | | 5-Hydroxytryptamine (Serotonin) Receptor 3A1 | | Serotonin Receptor 3A2 3 | | 5-Hydroxytryptamine Receptor 3A2 | | Serotonin-Gated Ion Channel Receptor2 3 | | 5HT3 Serotonin Receptor2 | | 5-HT-32 3 | | |
Export aliases for HTR3A gene to outside databasesPrevious GC identifers: GC11P116198 GC11P115357 GC11P113383 GC11P113351 GC11P109774 |
Summaries
for HTR3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HTR3A:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A ofthe type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, ahormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears thatthe heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor,since either subunit alone results in receptors with very low conductance and response amplitude. Alternativelyspliced transcript variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relativelynonselective, ion channel
 summary
for HTR3A: Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of
4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor
subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric
complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.
Gene Wiki entry for HTR3A
|
Genomic Views
for HTR3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HTR3A gene promoter:
GR NRSF form 1 GR-alpha NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.1-q23.2HTR3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P113879: view genomic region
(about GC identifiers)
Start:
|
113,845,603 bp from pter |
End:
|
113,861,035 bp from pter |
Size:
|
15,433 bases |
Orientation:
|
plus strand |
|
Proteins
for HTR3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 3A precursor Size: 478 amino acids; 55280 Da
Subunit: Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E;homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonistand antagonist affinity. Interacts with RIC3
Subcellular location: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane;Multi-pass membrane protein
Miscellaneous: The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomerscompared to that of HTR3A/HTR3B heteromers
Secondary accessions: B4DSY6 G5E986 O60854 Q7KZM7 Q99918 Q9BSZ9Alternative splicing: 5 isoforms: P46098-1 P46098-2 P46098-3 P46098-4 P46098-5 (No experimental confirmation available. Ref.7 (CD014118) sequence is in conflict in position: 342:C->W)Explore the universe of human proteins at neXtProt for HTR3A: NX_P46098
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P46098
HTR3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000860.2 NP_001155244.1 NP_998786.2
ENSEMBL proteins: ENSP00000424189 ENSP00000424776 ENSP00000423653 ENSP00000299961 ENSP00000347754 ENSP00000364648 ENSP00000437776 Reactome Protein details: P46098
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
HTR3A for ontologies About GeneDecksing
HTR3A Antibody Products:
Assay Products for HTR3A: |
Protein
Domains /
Families
for HTR3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR3A for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P46098ProtoNet protein and cluster: P46098 4 Blocks protein families: IPB001005 Myb DNA-binding domain IPB006201 Neurotransmitter-gated ion-channel IPB008132 5-hydroxytryptamine 3 receptor signature IPB008133 5-hydroxytryptamine 3 receptor A subunit signature
UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)subfamily. HTR3A sub-subfamily |
Function
for HTR3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which whenactivated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relativelynonselective, ion channel Genatlas biochemistry entry for HTR3A:5-hydroxytryptamine (serotonin) receptor,subtype 3a,coexpressed with HTR3B in the amygdala,caudate and hyppocampus,alsoexpressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3A (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3A |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
HTR3A for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Htr3atm1Jul for HTR3A
12 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Htr3a):
HTR3A for phenotypes About GeneDecksing
|
Pathways & Interactions
for HTR3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | SIDS Susceptibility Pathways | | | 3 | CREB Pathway | | | 4 | SLC-mediated transmembrane transport | | | 5 | GABA A receptor activation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR3A
1  BioSystems Pathway for HTR3A
3 
Reactome Pathways for HTR3A
1  PharmGKB Pathway for HTR3A
HTR3A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for HTR3A (P460983 ENSP000003477544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
HTR3A for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HTR3A for compounds About GeneDecksing
Compounds for HTR3A available from Tocris Bioscience About this table
2 HMDB Compounds for HTR3A About this table
10/17 DrugBank Compounds for HTR3A (see all 17) About this table
10/132 Novoseek chemical compound relationships for HTR3A gene (see all 132) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ondansetron |
92.8 |
201 |
8632370 (3), 8000726 (2), 9093728 (2), 8913711 (2) (see all 99) |
| granisetron |
92.2 |
104 |
19149526 (2), 7919451 (2), 16178752 (2), 1600046 (2) (see all 83) |
| 5-hydroxytryptamine |
90.6 |
356 |
17093363 (5), 17360702 (4), 1434911 (4), 10543288 (3) (see all 99) |
| tropisetron |
90.2 |
73 |
19149526 (2), 10776982 (2), 8000726 (1), 7851466 (1) (see all 57) |
| 2-methyl-5-ht |
88.6 |
41 |
9282959 (2), 8564266 (2), 8428202 (1), 7565620 (1) (see all 24) |
| dolasetron |
87.2 |
24 |
8141114 (2), 9093728 (2), 16444851 (1), 19205754 (1) (see all 20) |
| alosetron |
86.2 |
27 |
9659155 (3), 9663837 (2), 11966509 (2), 12360456 (2) (see all 19) |
| ketanserin |
83.6 |
40 |
1338307 (2), 1354103 (1), 8223939 (1), 7851466 (1) (see all 36) |
| metoclopramide |
82.4 |
41 |
8513986 (2), 1941605 (1), 1723361 (1), 8000726 (1) (see all 33) |
| palonosetron |
81.3 |
15 |
18822676 (2), 16444851 (1), 17366928 (1), 15102873 (1) (see all 12) |
Search CenterWatch for drugs/clinical trials and news about HTR3A / 5HT3A
|
Transcripts
for HTR3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HTR3A gene (3 alternative transcripts): NM_000869.5 NM_001161772.2 NM_213621.3 Unigene Cluster for HTR3A: 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic Hs.413899 [show with all ESTs]Unigene Representative Sequence: NM_2136218 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504030(uc010rxa.2 uc009yyx.3) ENST00000506841 ENST00000510849
ENST00000299961(uc010rxc.2) ENST00000502622 ENST00000355556(uc010rxb.2)
ENST00000375498 ENST00000535865
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3A (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR3A (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): HTR3A (NM_213621) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR3A |
Additional cDNA sequence: AF498984.1 AJ003078.1 AJ003079.1 AK299973.1 AK304630.1 AK313896.1 BC002354.2 BC004453.1 BT007204.1 D49394.1 NR_046363.1 S82612.1 5 DOTS entries: DT.100645205 DT.100768448 DT.100684406 DT.92474117 DT.454166 24/55 AceView cDNA sequences (see all 55): AL525291 NM_213621 BC002354 BC004453 AJ003078 CD014118 CR626153 NM_000869 AJ003080 AF498984 BF219778 AI435492 AW249320 S82612 BE252349 BE792965 AW178407 BI117729 BI117422 AA731733 D49394 AA703169 BE793724 BE256892
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for HTR3A About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HTR3A
|
Expression
for HTR3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGACCCC
About this image
See HTR3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR3A
SOURCE GeneReport for Unigene cluster: Hs.413899
UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098Tissue specificity: Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of thespleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta
SABiosciences Expression via Pathway-Focused PCR Arrays including HTR3A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTR3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR3A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3A |
Orthologs
for HTR3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR3A gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HTR3A1 |
5-hydroxytryptamine (serotonin) receptor 3A |
71.96(n)
70.77(a) |
|
428247 XM_425806.2 XP_425806.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5716411 |
5-hydroxytryptamine receptor 3A-like |
68.35(n)
69.2(a) |
|
571641 XM_695246.3 XP_700338.3 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
15(a) |
possible ortholog |
Group9.3(266661-268793) |
worm
(Caenorhabditis elegans) |
Secernentea |
acr-173 |
acetylcholine receptor protein |
29(a)
(best of 5) |
|
V(2608501-2613987) -- |
ENSEMBL Gene Tree for HTR3A (if available)
TreeFam Gene Tree for HTR3A (if available) |
Paralogs
for HTR3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HTR3A gene
- HTR3E2 HTR3C2 HTR3D2 HTR3B2 ZACN2
18 SIMAP similar genes for HTR3A using alignment to 11 protein entries: 5HT3A_HUMAN (see all proteins):CHRND HTR3B HTR3E CHRNB1 CHRNA2 CHRNA4
CHRNA10 CHRNA6 HTR3C CHRNA9 CHRFAM7A CHRNB2
CHRNB3 CHRNA5 CHRNA1 CHRNB4 CHRNA3 HTR3D
HTR3A for paralogs About GeneDecksing
|
Genomic Variants
for HTR3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HTR3A (113845603 - 113861035 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HTR3A: --
Human Gene Mutation Database (HGMD): HTR3A
Locus Specific Mutation Databases (LSDB): HTR3A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR3A |
|
Disorders
/ Diseases
for HTR3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR3A for disorders About GeneDecksing
OMIM gene information: 182139
OMIM disorders: --
20/117  diseases for HTR3A (see all 117): About MalaCardsgilles de la tourette syndrome obsessive-compulsive disorder sudden infant death syndrome cyclic vomiting syndrome
generalized anxiety disorder machado-joseph disease restless legs syndrome cluster headache
anxiety disorder cocaine abuse social phobia bulimia nervosa
supranuclear palsy borderline personality disorder progressive supranuclear palsy hypochondriasis
motion sickness premature ejaculation myocardial infarction phobia
10 diseases from the University of Copenhagen DISEASES database for HTR3A:Irritable bowel syndrome Constipation Motion sickness Diarrhea
Fibromyalgia Migraine Pain agnosia Dyspepsia
Schizophrenia Gastroparesis 10/93 Novoseek disease relationships for HTR3A gene (see all 93) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| migraine |
63.7 |
55 |
17120594 (3), 1468904 (2), 8869767 (2), 9949863 (2) (see all 42) |
| serotonin syndrome |
62 |
8 |
11889332 (2), 15635814 (1), 20013432 (1), 20092221 (1) (see all 7) |
| schizophrenia |
58.2 |
37 |
18622264 (3), 7831440 (2), 10831488 (2), 12151468 (1) (see all 30) |
| functional gastrointestinal disorder |
56.7 |
2 |
7949460 (1), 19750433 (1) |
| functional dyspepsia |
55.1 |
1 |
17439064 (1) |
| functional bowel disorder |
51.6 |
2 |
17258778 (1), 17620086 (1) |
| major depression |
42.8 |
10 |
2392511 (1), 8561196 (1), 8131152 (1), 9015799 (1) (see all 10) |
| fibromyalgia primary |
42.7 |
3 |
8856622 (2), 9088121 (1) |
| obsessive-compulsive disorder |
39.2 |
3 |
17430417 (1), 12883138 (1), 9203092 (1) |
| psychiatric disorder |
34.9 |
4 |
7542676 (1), 15353848 (1), 1609040 (1), 17728663 (1) |
Genetic Association Database (GAD): HTR3A
Human Genome Epidemiology (HuGE) Navigator: HTR3A (56 documents)
Export disorders for HTR3A gene to outside databases
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Publications
for HTR3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for HTR3A gene, integrated from 9 sources (see all 1237):
(articles sorted by number of sources associating them with HTR3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. (PubMed id 12867984)1, 2, 3, 9 Kelley S.P....Peters J.A. (2003)
- Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PubMed id 15293096)1, 2, 4, 9 Frank B.... Rappold G. (2004)
- Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. (PubMed id 7565620)1, 2, 9 Miyake A.... Akuzawa S. (1995)
- A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. (PubMed id 14557147)1, 4, 9 Melke J....Eriksson E. (2003)
- Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response. (PubMed id 12363396)1, 4, 9 Gutierrez B....Kerwin R.W. (2002)
- Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3. (PubMed id 15809299)1, 2, 9 Cheng A.... Connolly C.N. (2005)
- Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists. (PubMed id 15115912)1, 4, 9 Kaiser R....Brockmoller J. (2004)
- Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder. (PubMed id 11505217)1, 4, 9 Niesler B....Rappold G.A. (2001)
- The 5-HT3B subunit is a major determinant of serotonin-receptor function. (PubMed id 9950429)1, 2, 9 Davies P.A.... Kirkness E.F. (1999)
- Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. (PubMed id 16487942)1, 2 Yamada K....Yoshikawa T. (2006)
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External Searches for HTR3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HTR3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HTR3A gene
(According to HUGE)
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Specialized Databases showing HTR3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HTR3A | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HTR3A gene:
Search GeneIP for patents involving HTR3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HTR3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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