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HTR3A Gene

protein-coding   GIFtS: 68
GCID: GC11P113879

5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic

(Previous name: 5-hydroxytryptamine (serotonin) receptor 3A)
(Previous symbol: HTR3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 3A, Ionotropic1 2     5-HT3R2 3
HTR31 2 3 5     5-Hydroxytryptamine Receptor 32 3
Serotonin Receptor 3A2 3     5HT3R2 3
Serotonin-Gated Ion Channel Receptor2 3     5-Hydroxytryptamine (Serotonin) Receptor 3A1
5-HT-32 3     5-Hydroxytryptamine Receptor 3A2
5-HT3-A2 3     5HT3 Serotonin Receptor2
5-HT3A2 3     

External Ids:    HGNC: 52971   Entrez Gene: 33592   Ensembl: ENSG000001667367   OMIM: 1821395   UniProtKB: P460983   

Export aliases for HTR3A gene to outside databases

Previous GC identifers: GC11P116198 GC11P115357 GC11P113383 GC11P113351 GC11P109774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR3A Gene:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A
of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a
neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after
activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full
functional features of this receptor, since either subunit alone results in receptors with very low conductance
and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been
identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for HTR3A Gene:
HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic) is a protein-coding gene. Diseases associated with HTR3A include serotonin syndrome, and fibromyalgia. GO annotations related to this gene include serotonin receptor activity and receptor activity. An important paralog of this gene is HTR3E.

UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise
relatively nonselective, ion channel

summary for HTR3A Gene:
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of
4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor
subtypes have been identified (5-HT3A-E). The 5-HT3B-E subtypes do not form functional homo-oligomeric
complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.

Gene Wiki entry for HTR3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR3A gene promoter:
         GR   NRSF form 1   GR-alpha   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR3A promoter sequence
   Search Chromatin IP Primers for HTR3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1   Ensembl cytogenetic band:  11q23.2   HGNC cytogenetic band: 11q23.1-q23.2

HTR3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR3A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P113879:  view genomic region     (about GC identifiers)

Start:
113,845,603 bp from pter      End:
113,861,035 bp from pter
Size:
15,433 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 3A precursor  
Size: 478 amino acids; 55280 Da
Subunit: Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E;
homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased
agonist and antagonist affinity. Interacts with RIC3
Miscellaneous: The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers
compared to that of HTR3A/HTR3B heteromers
Secondary accessions: B4DSY6 G5E986 O60854 Q7KZM7 Q99918 Q9BSZ9
Alternative splicing: 5 isoforms:  P46098-1   P46098-2   P46098-3   P46098-4   P46098-5   (No experimental confirmation available. Ref.7 (CD014118) sequence is in conflict in position: 342:C->W)

Explore the universe of human proteins at neXtProt for HTR3A: NX_P46098

Explore proteomics data for HTR3A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn28, Asn104, Asn170, Asn186
  • Modification sites at PhosphoSitePlus

  • See HTR3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000860.2  NP_001155244.1  NP_998786.2  

    ENSEMBL proteins: 
     ENSP00000424189   ENSP00000424776   ENSP00000423653   ENSP00000299961   ENSP00000347754  
     ENSP00000364648   ENSP00000437776  
    Reactome Protein details: P46098

    HTR3A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HTR3A

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    Cloud-Clone Corp. CLIAs for HTR3A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTR3: Ligand-gated ion channels / 5-HT (serotonin) receptors, ionotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT3A
    5-HT3 receptors

    Selected InterPro protein domains (see all 7):
     IPR027361 Acetylcholine_rcpt_TM
     IPR018000 Neurotransmitter_ion_chnl_CS
     IPR008132 5HT3_rcpt
     IPR006201 Neur_channel
     IPR006202 Neur_chan_lig-bd

    Graphical View of Domain Structure for InterPro Entry P46098

    ProtoNet protein and cluster: P46098

    4 Blocks protein domains:
    IPB001005 Myb DNA-binding domain
    IPB006201 Neurotransmitter-gated ion-channel
    IPB008132 5-hydroxytryptamine 3 receptor signature
    IPB008133 5-hydroxytryptamine 3 receptor A subunit signature


    UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098
    Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2)
    subfamily. HTR3A sub-subfamily


    HTR3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT3A_HUMAN, P46098
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel,
    which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise
    relatively nonselective, ion channel

         Genatlas biochemistry entry for HTR3A:
    5-hydroxytryptamine (serotonin) receptor,subtype 3a,coexpressed with HTR3B in the amygdala,caudate and
    hyppocampus,also expressed in other tissues,component of HTR3 receptor,mediating rapid excitatory responses

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9950429
    GO:0004993serotonin receptor activity IDA7565620
    GO:0005230extracellular ligand-gated ion channel activity ----
    GO:0005232serotonin-activated cation-selective channel activity IEA--
    GO:0005249voltage-gated potassium channel activity IEA--
         
    HTR3A for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Htr3a):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  nervous system 
     renal/urinary system  reproductive system 

    HTR3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr3atm1Jul for HTR3A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR3A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR3A

    miRNA
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    miRTarBase miRNAs that target HTR3A:
    hsa-mir-9-5p (MIRT021413)

    Block miRNA regulation of human, mouse, rat HTR3A using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HTR3A:
    hsa-miR-4271 hsa-miR-4261 hsa-miR-9* hsa-miR-2110
    SwitchGear 3'UTR luciferase reporter plasmidHTR3A 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HTR3A

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): HTR3A (NM_213621)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR3A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT3A_HUMAN, P46098: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell
    membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7565620
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    HTR3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR3A About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2CREB Pathway
    Intracellular Calcium Signaling0.50
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    4Circadian entrainment
    Serotonergic synapse0.33
    5SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR3A
        Intracellular Calcium Signaling

    1 BioSystems Pathway for HTR3A
        SIDS Susceptibility Pathways

    1 Reactome Pathway for HTR3A
        Ligand-gated ion channel transport

    1 PharmGKB Pathway for HTR3A
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for HTR3A):
        Serotonergic synapse


    HTR3A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR3A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for HTR3A (P460983 ENSP000003477544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA5P110213, ENSP000003241734I2D: score=2 STRING: ENSP00000324173
    CANXP278243, ENSP000002474614I2D: score=2 STRING: ENSP00000247461
    HTR3BENSP000002601914STRING: ENSP00000260191
    HTR3CENSP000003226174STRING: ENSP00000322617
    HTR3DENSP000004054094STRING: ENSP00000405409
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS7565620
    GO:0006811ion transport ----
    GO:0006812cation transport TAS7565620
    GO:0007210serotonin receptor signaling pathway IDA7565620
    GO:0007268synaptic transmission TAS7565620

    HTR3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for HTR3A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Zacopride hydrochlorideHighly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist[90182-92-6]
    Ondansetron hydrochlorideSelective 5-HT3 antagonist[103639-04-9]
    Granisetron hydrochloride5-HT3 antagonist[107007-99-8]
    Tropisetron hydrochloridePotent 5-HT3 receptor antagonist; orally active[105826-92-4]
    SR 57227 hydrochloride Potent, selective 5-HT3 agonist [77145-61-0]

    2 HMDB Compounds for HTR3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    OndansetronOndansetron (see all 4)99614-02-5--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    Selected DrugBank Compounds for HTR3A (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ondansetron-- 99614-02-5targetantagonist12032025 8588861 9506240 20098535 19320280 11763467 11919526 11752352 11972287 10517265 10065930 15740177 17269994
    Palonosetron-- 119904-90-4targetantagonist14504060 14640928 14760130 15232725 15102873 16163194 17026451 15378559 11752352 19852528 17106506 15139789 14635083
    Alosetron-- 122852-42-0targetantagonist10776833 14596662 17138606 18555935 11060667 10848662 11752352 20136586 15061683 10429744 10354345
    Dolasetron-- 115956-12-2targetantagonist1397053 9506240 9257083 14586600 11752352 8141114 7493546 15740177 9341357 14635083
    GranisetronAPF530 (see all 5)109889-09-0targetantagonist16044252 11814868 17093363 12943486 11752352 17379085 10882387 15740177 10412832
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist10446735 8930006 17587360 11607047 11752352 10446734
    TubocurarineD-Tubocurarine (see all 6)6989-98-6targetantagonist1691468 7684066 12243766 10066903 16723497
    Cisapride-- 81098-60-4targetagonist8093733 9697104 10328995 1600046
    ChloroprocaineChloroprocain (see all 3)133-16-4targetantagonist17139284 17016423
    Procaine-- 59-46-1targetantagonist11752352 7539114

    Selected Novoseek inferred chemical compound relationships for HTR3A gene (see all 132)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ondansetron 92.8 201 8632370 (3), 8000726 (2), 9093728 (2), 8913711 (2) (see all 99)
    granisetron 92.2 104 19149526 (2), 7919451 (2), 16178752 (2), 1600046 (2) (see all 83)
    5-hydroxytryptamine 90.6 356 17093363 (5), 17360702 (4), 1434911 (4), 10543288 (3) (see all 99)
    tropisetron 90.2 73 19149526 (2), 10776982 (2), 8000726 (1), 7851466 (1) (see all 57)
    2-methyl-5-ht 88.6 41 9282959 (2), 8564266 (2), 8428202 (1), 7565620 (1) (see all 24)
    dolasetron 87.2 24 8141114 (2), 9093728 (2), 16444851 (1), 19205754 (1) (see all 20)
    alosetron 86.2 27 9659155 (3), 9663837 (2), 11966509 (2), 12360456 (2) (see all 19)
    ketanserin 83.6 40 1338307 (2), 1354103 (1), 8223939 (1), 7851466 (1) (see all 36)
    metoclopramide 82.4 41 8513986 (2), 1941605 (1), 1723361 (1), 8000726 (1) (see all 33)
    palonosetron 81.3 15 18822676 (2), 16444851 (1), 17366928 (1), 15102873 (1) (see all 12)



    HTR3A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR3A gene (3 alternative transcripts): 
    NM_000869.5  NM_001161772.2  NM_213621.3  

    Unigene Cluster for HTR3A:

    5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
    Hs.413899  [show with all ESTs]
    Unigene Representative Sequence: NM_213621
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504030(uc010rxa.2 uc009yyx.3) ENST00000506841 ENST00000510849
    ENST00000299961(uc010rxc.2) ENST00000502622 ENST00000355556(uc010rxb.2)
    ENST00000375498 ENST00000535865

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate HTR3A:
    hsa-miR-4271 hsa-miR-4261 hsa-miR-9* hsa-miR-2110
    SwitchGear 3'UTR luciferase reporter plasmidHTR3A 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat HTR3A

    Additional mRNA sequence: 

    AF498984.1 AJ003078.1 AJ003079.1 AK299973.1 AK304630.1 AK313896.1 BC002354.2 BC004453.1 
    BT007204.1 D49394.1 NR_046363.1 S82612.1 

    5 DOTS entries:

    DT.100645205  DT.100768448  DT.100684406  DT.92474117  DT.454166 

    Selected AceView cDNA sequences (see all 55):

    AF498984 BC002354 NM_000869 CD014118 AL525291 NM_213621 AJ003078 BC004453 
    BF219778 AJ003080 CR626153 BE252349 AW248713 AL561835 AI076288 AL525251 
    AI916856 AI435492 AW248903 BI117729 BG397761 AA912176 BI117422 BG341613 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HTR3A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -                 -                                                   
    SP2:                    -                 -                                                   
    SP3:                    -                 -                 -     -                           
    SP4:                                      -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for HTR3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR3A expression in normal human tissues (normalized intensities)      HTR3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGACCCC
    HTR3A Expression
    About this image


    HTR3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
    HTR3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413899

    UniProtKB/Swiss-Prot: 5HT3A_HUMAN, P46098
    Tissue specificity: Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the
    spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR3A: 
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              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HTR3A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr3a1 , 5 5-hydroxytryptamine (serotonin) receptor 3A1, 5 83.92(n)1
    86.62(a)1
      9 (26.53 cM)5
    155611  NM_013561.21  NP_038589.21 
     488992145 
    chicken
    (Gallus gallus)
    Aves HTR3A1 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 73.85(n)
    73.33(a)
      428247  XM_425806.3  XP_425806.3 
    lizard
    (Anolis carolinensis)
    Reptilia HTR3A6
    5-hydroxytryptamine (serotonin) receptor 3A, ionot...
    67(a)
    1 ↔ 1
    GL343354.1(177825-190433)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5716411 5-hydroxytryptamine receptor 3A-like 67.79(n)
    68.54(a)
      571641  XM_695246.4  XP_700338.4 


    ENSEMBL Gene Tree for HTR3A (if available)
    TreeFam Gene Tree for HTR3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR3A gene
    HTR3E2  CHRNA102  CHRNA92  HTR3B2  ZACN2  CHRNA72  CHRFAM7A2  HTR3C2  
    HTR3D2  
    17 SIMAP similar genes for HTR3A using alignment to 11 protein entries:     5HT3A_HUMAN (see all proteins):
    CHRND    HTR3B    HTR3E    CHRNB1    CHRNA2    CHRNA4
    CHRNA10    CHRNA6    HTR3C    CHRNA9    CHRFAM7A    CHRNB2
    CHRNB3    CHRNA5    CHRNA1    CHRNB4    CHRNA3

    HTR3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR3A (see all 561)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57948951,2
    C--109776936(+) TGCTC-/CT/TC 
            
    CGACC
    3 -- int1 us2k12NA CSA 8
    rs710635381,2
    C--109784398(-) TTTTCT/-CTTTT 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1878330501,2
    --113707249(+) TAGTCG/TCAGCT 2 -- us2k10--------
    rs285517421,2
    C--113707382(+) AAAAAA/GAAAAA 2 -- us2k1 trp30--------
    rs1388664351,2
    --113707588(+) TTTGGG/TGCCCT 2 -- us2k10--------
    rs1404790591,2
    --113707610(+) CTGCCC/TTCATA 2 -- us2k10--------
    rs1130495011,2
    F--113707635(+) GGAAAT/AGCTTG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1918416781,2
    --113707643(+) TTGGAC/GCTAAT 2 -- us2k10--------
    rs79265921,2
    C,F,H--113707685(+) AAGCAC/TATGAC 2 -- us2k14Minor allele frequency- T:0.01NS EA 420
    rs122762841,2
    C,F,H--113707694(+) ACTTAA/GGAGAA 2 -- us2k1 trp37Minor allele frequency- G:0.03NS EA WA CSA 540

    HapMap Linkage Disequilibrium report for HTR3A (113845603 - 113861035 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HTR3A: --
    Human Gene Mutation Database (HGMD): HTR3A
    Locus Specific Mutation Databases (LSDB): HTR3A

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR3A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182139    OMIM disorders: --

    Selected diseases for HTR3A (see all 111):    About MalaCards
    serotonin syndrome    fibromyalgia    cyclic vomiting syndrome    hypochondriasis
    irritable bowel syndrome    motion sickness    social phobia    cluster headache
    headache    premature ejaculation    dyspepsia    cocaine abuse
    sialadenitis    generalized anxiety disorder    collagen disease    psychotic disorder
    early-onset schizophrenia    anxiety disorder    labyrinthitis    neuroleptic malignant syndrome

    11 diseases from the University of Copenhagen DISEASES database for HTR3A:
    Irritable bowel syndrome     Constipation     Migraine     Schizophrenia
    Fibromyalgia     Motion sickness     Diarrhea     Pain agnosia
    Anxiety disorder     Dyspepsia     Gastroparesis

    HTR3A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for HTR3A gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 63.7 55 17120594 (3), 1468904 (2), 8869767 (2), 9949863 (2) (see all 42)
    serotonin syndrome 62 8 11889332 (2), 15635814 (1), 20013432 (1), 20092221 (1) (see all 7)
    schizophrenia 58.2 37 18622264 (3), 7831440 (2), 10831488 (2), 12151468 (1) (see all 30)
    functional gastrointestinal disorder 56.7 2 7949460 (1), 19750433 (1)
    functional dyspepsia 55.1 1 17439064 (1)
    functional bowel disorder 51.6 2 17258778 (1), 17620086 (1)
    major depression 42.8 10 2392511 (1), 8561196 (1), 8131152 (1), 9015799 (1) (see all 10)
    fibromyalgia primary 42.7 3 8856622 (2), 9088121 (1)
    obsessive-compulsive disorder 39.2 3 17430417 (1), 12883138 (1), 9203092 (1)
    psychiatric disorder 34.9 4 7542676 (1), 15353848 (1), 1609040 (1), 17728663 (1)

    Genetic Association Database (GAD): HTR3A
    Human Genome Epidemiology (HuGE) Navigator: HTR3A (56 documents)

    Export disorders for HTR3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR3A gene, integrated from 10 sources (see all 1246):
    (articles sorted by number of sources associating them with HTR3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. (PubMed id 12867984)1, 2, 3, 9 Kelley S.P.... Peters J.A. (Nature 2003)
    2. Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. (PubMed id 15293096)1, 2, 4, 9 Frank B.... Rappold G. (Clin. Rheumatol. 2004)
    3. Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression. (PubMed id 16487942)1, 2, 4 Yamada K....Yoshikawa T. (Biol. Psychiatry 2006)
    4. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. (PubMed id 7565620)1, 2, 9 Miyake A.... Akuzawa S. (Mol. Pharmacol. 1995)
    5. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. (PubMed id 14557147)1, 4, 9 Melke J....Eriksson E. (Arch. Gen. Psychiatry 2003)
    6. Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response. (PubMed id 12363396)1, 4, 9 GutiAcrrez B....Kerwin R.W. (Schizophr. Res. 2002)
    7. Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients. (PubMed id 18622264)1, 4, 9 Gu B....Xing Q.H. (Pharmacogenet. Genomics 2008)
    8. Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders. (PubMed id 19741568)1, 4, 9 Hammer C....Niesler B. (Pharmacogenet. Genomics 2009)
    9. Candidate genotypes associated with functional dyspepsia. (PubMed id 18331431)1, 4, 9 van Lelyveld N....Samsom M. (Neurogastroenterol. Motil. 2008)
    10. Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3. (PubMed id 15809299)1, 2, 9 Cheng A.... Connolly C.N. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3359 HGNC: 5297 AceView: HTR3A Ensembl:ENSG00000166736 euGenes: HUgn3359
    ECgene: HTR3A Kegg: 3359 H-InvDB: HTR3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HTR3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR3A gene:
    Search GeneIP for patents involving HTR3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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