HTR2C Gene
protein-coding GIFtS: 73
GCID: GC0XP113818
|
|
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled(Previous name: 5-hydroxytryptamine (serotonin) receptor 2C )
(Previous symbol: HTR1C)
| |
Aliases
for HTR2C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled1 2 | | 5-HTR2C2 3 | | 5-HT2C1 2 3 | | 5-Hydroxytryptamine Receptor 1C2 3 | | HTR1C1 2 3 | | 5-Hydroxytryptamine (Serotonin) Receptor 2C1 | | Serotonin Receptor 2C2 3 | | 5-Hydroxytryptamine Receptor 2C2 | | 5-HT-1C2 3 | | 5-Hydroxytryptamine Receptor-1c2 | | 5-HT-2C2 3 | | Serotonin 5-HT-2C Receptor2 | | 5-HT1C2 3 | | |
Export aliases for HTR2C gene to outside databasesPrevious GC identifers: GC0XP108837 GC0XP110943 GC0XP111854 GC0XP112582 GC0XP113641 GC0XP103403 |
Summaries
for HTR2C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HTR2C:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding toseveral receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors,which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor andits mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted toinosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptorand generate receptor isoforms that differ in their ability to interact with G proteins and the activation ofphospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervoussystem. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb2012)
UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system
 summary
for HTR2C: Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid
plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation,
thermoregulation, penile erections and anxiety. The human 5-HT2C receptor gene has been localized to
chromosome X (Xq24).
Gene Wiki entry for HTR2C (5-HT2C receptor)
|
Genomic Views
for HTR2C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_028405.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HTR2C gene promoter:
MEF-2A AREB6 MAZR POU3F1 aMEF-2 CUTL1 AP-2gamma LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR2C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR2C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq23 HGNC cytogenetic band: Xq23HTR2C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP113818: view genomic region
(about GC identifiers)
Start:
|
113,818,551 bp from pter |
End:
|
114,144,624 bp from pter |
Size:
|
326,074 bases |
Orientation:
|
plus strand |
|
Proteins
for HTR2C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 2C precursor Size: 458 amino acids; 51821 Da
Subunit: Interacts with MPDZ. Interacts with ARRB2
Subcellular location: Cell membrane; Multi-pass membrane protein
Rna editing: Modified_positions=156, 158, 160; Note=Partially edited. RNA editing generates receptor isoforms thatdiffer in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggestingthat this RNA processing event may contribute to the modulation of serotonergic neurotransmission in the centralnervous system
Secondary accessions: B1AMW4 Q5VUF8 Q9NP28Alternative splicing: 2 isoforms: P28335-1 P28335-2 Explore the universe of human proteins at neXtProt for HTR2C: NX_P28335
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P28335
HTR2C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000859.1 NP_001243689.1 NP_001243690.1
ENSEMBL proteins: ENSP00000361019 ENSP00000276198 ENSP00000361018 Reactome Protein details: P28335
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HTR2C for ontologies About GeneDecksing
HTR2C Antibody Products:
Assay Products for HTR2C: |
Protein
Domains /
Families
for HTR2C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR2C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P28335ProtoNet protein and cluster: P28335 2 Blocks protein families: IPB000377 5-hydroxytryptamine 2C receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335Domain: The PDZ domain-binding motif is involved in the interaction with MPDZSimilarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HTR2C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system Genatlas biochemistry entry for HTR2C:5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled receptorsuperfamily,activating the phosphatidylinositol cycle
Clone
Products: |  | EMD Millipore Clones for the Expression of HTR2C | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTR2C (NM_000868) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR2C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2C |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
HTR2C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HTR2C:
Animal Models:
Mouse knock-outs for HTR2C: Htr2ctm1Jul Htr2ctm2Lex
10 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Htr2c):
HTR2C for phenotypes About GeneDecksing
|
Pathways & Interactions
for HTR2C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Monoamine GPCRs | | | 3 | Signaling by GPCR | | | 4 | G alpha (q) signalling events | | | 5 | Signaling in Gap Junctions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for HTR2C
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HTR2C
1  GeneGo (Thomson Reuters) Pathway for HTR2C
3  BioSystems Pathways for HTR2C
5/9 
Reactome Pathways for HTR2C (see all 9)
1  PharmGKB Pathway for HTR2C
3 
Kegg Pathways (Kegg details for HTR2C):
HTR2C for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR2C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/137 Interacting proteins for HTR2C (P283352, 3 ENSP000002761984) via UniProtKB, MINT, STRING, and/or I2D (see all 137)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
HTR2C for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR2C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HTR2C for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for HTR2C |
Compounds for HTR2C available from Tocris Bioscience About this table
3 HMDB Compounds for HTR2C About this table
10/36 DrugBank Compounds for HTR2C (see all 36) About this table
10/52 Novoseek chemical compound relationships for HTR2C gene (see all 52) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| agomelatine |
84.8 |
11 |
17477886 (1), 16687314 (1), 16918076 (1), 16869122 (1) (see all 10) |
| mesulergine |
83 |
4 |
1407010 (1), 2043924 (1), 9166921 (1), 10952674 (1) |
| 5-hydroxytryptamine |
79.3 |
80 |
1355262 (4), 10952674 (3), 15242780 (2), 12673575 (2) (see all 30) |
| m-chlorophenylpiperazine |
74.6 |
13 |
7760026 (1), 10870873 (1), 10435401 (1), 15467976 (1) (see all 7) |
| maoa |
73.4 |
10 |
12822741 (1), 15241435 (1), 19566713 (1), 19032968 (1) (see all 8) |
| ketanserin |
72.9 |
4 |
16204332 (1), 17209458 (1), 8584618 (1), 10952674 (1) |
| 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane |
71.2 |
5 |
7760026 (1), 8095238 (1), 8780834 (1) |
| metergoline |
70.6 |
1 |
1403790 (1) |
| 5-carboxamidotryptamine |
69.6 |
2 |
12588512 (1) |
| mianserin |
67 |
3 |
1403790 (1), 2043924 (1), 2045831 (1) |
4 PharmGKB related drug/compound annotations for HTR2C geneAbout this table
Search CenterWatch for drugs/clinical trials and news about HTR2C / 5HT2C
|
Transcripts
for HTR2C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HTR2C gene (3 alternative transcripts): NM_000868.2 NM_001256760.1 NM_001256761.1 Unigene Cluster for HTR2C: 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Hs.149037 [show with all ESTs]Unigene Representative Sequence: NM_0012567603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371951 ENST00000276198(uc004epu.1 uc010nqc.1 uc004epv.1)
ENST00000371950
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HTR2C (NM_000868) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR2C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2C |
Additional cDNA sequence: AF208053.1 AF498983.1 AK295753.1 AK308766.1 AY114104.1 BC028688.1 BC095543.1 BX648587.1 M81778.1 U49516.1 4 DOTS entries: DT.108661 DT.100727990 DT.92416684 DT.92416685 20 AceView cDNA sequences: Z40928 NM_000868 U49516 AF498983 N47111 AF208053 BX648587 AI970140 CB565884 M81778 BX505080 BX118108 BC028688 BG704515 AW002513 N50321 CD657722 AI825491 CD103423 AY114104
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for HTR2C
|
Expression
for HTR2C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTACAAAG
About this image
See HTR2C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR2C
SOURCE GeneReport for Unigene cluster: Hs.149037
SABiosciences Expression via Pathway-Focused PCR Arrays including HTR2C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR2C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTR2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR2C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR2C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2C |
Orthologs
for HTR2C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR2C gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HTR2C1 |
5-hydroxytryptamine (serotonin) receptor 2C |
64.92(n)
62.79(a) |
|
428707 XM_426265.3 XP_426265.2 |
lizard
(Anolis carolinensis) |
Reptilia |
HTR2C6 |
-- |
58(a) |
1 ↔ 1 |
GL343403.1(742046-769396) |
African clawed frog
(Xenopus laevis) |
Amphibia |
AJ549811.12 |
-- |
72.62(n) |
|
AJ549811.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
htr2cl11 |
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like more |
60.07(n)
61.2(a) |
|
100000981 NM_001129893.1 NP_001123365.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
5-HT23 |
serotonin receptor signaling pathway
G-protein more |
44(a) |
|
3 82C5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
M03F4.33
ser-11 |
G-protein coupled receptor3
Protein SER-11 |
41(a)
(best of 3)3
48.75(n)1
38.12(a)1 |
|
X(4985611-4990413)3
1817161 NM_001029557.11 NP_001024728.11 |
ENSEMBL Gene Tree for HTR2C (if available)
TreeFam Gene Tree for HTR2C (if available) |
Paralogs
for HTR2C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HTR2C gene
- TAAR62 HTR2A2 HTR62 TAAR22 ADRB12 TAAR82 HRH22 HTR2B2
- DRD12 TAAR12 ADRB22 HTR42 DRD52 ADRB32 TAAR52
18/20 SIMAP similar genes for HTR2C using alignment to 6 protein entries: 5HT2C_HUMAN (see all proteins)
(see all similar genes):HTR2B HTR2A ADRA1A ADRA2C CHRM1 DRD3
SSTR5 HTR1E ADRA1B HTR1D HTR1F HTR4
HTR1B HTR5A OPRM1 5HT1A CHRM2 HTR1A
HTR2C for paralogs About GeneDecksing
|
Genomic Variants
for HTR2C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335Polymorphism: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for Ser
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HTR2C (113818551 - 114068551 bp, first 250kb of HTR2C)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for HTR2C
4 CNVs: 7758 96898 83682 52908
2 Indels: 13239 96899
Human Gene Mutation Database (HGMD): HTR2C
Locus Specific Mutation Databases (LSDB): HTR2C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR2C |
|
Disorders
/ Diseases
for HTR2C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR2C for disorders About GeneDecksing
OMIM gene information: 312861
OMIM disorders: --
20/52  diseases for HTR2C (see all 52): About MalaCardsattention deficit hyperactivity disorder choroiditis generalized anxiety disorder obsessive-compulsive disorder
anxiety disorder prader-willi syndrome borderline personality disorder seasonal affective disorder
temporal lobe epilepsy premature ejaculation anorexia nervosa tardive dyskinesia
major depressive disorder personality disorder bipolar affective disorder autism spectrum disorder
bulimia nervosa panic disorder cocaine dependence sleep apnea
4 diseases from the University of Copenhagen DISEASES database for HTR2C:Schizophrenia Cyclothymic disorder lingual-facial-buccal dyskinesia Migraine 10/19 Novoseek disease relationships for HTR2C gene (see all 19) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
65.6 |
27 |
15717293 (5), 12673575 (2), 14643089 (2), 18855532 (1) (see all 17) |
| bipolar disorder |
55.8 |
9 |
18504633 (2), 19411841 (1), 20015120 (1), 9342201 (1) (see all 6) |
| major depression |
55.1 |
9 |
12853111 (2), 17477886 (1), 19411841 (1), 11526472 (1) (see all 7) |
| psychiatric disorder |
37.8 |
18 |
19411841 (3), 12853111 (3), 20015120 (2), 18379171 (2) (see all 8) |
| attention-deficit hyperactivity disorder |
37.5 |
2 |
14574222 (1), 15303127 (1) |
| mood disorders |
33.7 |
3 |
11526472 (1), 18715570 (1) |
| alcoholism |
31 |
7 |
15304380 (3), 10776672 (2), 14574222 (1), 8612062 (1) |
| psychotic |
28.6 |
2 |
9700207 (1) |
| migraine |
24.6 |
11 |
12555241 (2), 8743744 (1), 15109354 (1), 7622823 (1) (see all 6) |
| obesity |
22.8 |
12 |
17016522 (3), 15048662 (3), 19079077 (1), 15381968 (1) (see all 8) |
Genetic Association Database (GAD): HTR2C
Human Genome Epidemiology (HuGE) Navigator: HTR2C (140 documents)
Export disorders for HTR2C gene to outside databases
|
Publications
for HTR2C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for HTR2C gene, integrated from 9 sources (see all 492):
(articles sorted by number of sources associating them with HTR2C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. (PubMed id 10206230)1, 2, 4 Samochowiec J.... Sander T. (1999)
- Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. (PubMed id 7895773)1, 2, 3 Stam N.J.... Olijve W. (1994)
- A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. (PubMed id 15048662)1, 4, 9 Pooley E.C....Harrison P.J. (2004)
- A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. (PubMed id 16157158)1, 4, 9 Praschak-Rieder N....Levitan R. (2005)
- Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. (PubMed id 15304380)1, 4, 9 Mottagui-Tabar S....Heilig M. (2004)
- Depression in Alzheimer's disease: the effect of serotonin receptor gene variation. (PubMed id 12707936)1, 4, 9 Holmes C....Lovestone S. (2003)
- Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). (PubMed id 7557992)1, 2, 9 Lappalainen J.... Goldman D. (1995)
- Serotonin-2A and 2C receptor gene polymorphisms in Japanese patients with obstructive sleep apnea. (PubMed id 16258205)1, 4, 9 Sakai K....Gejyo F. (2005)
- Analysis of SNP profiles in patients with major depressive disorder. (PubMed id 15927089)1, 4, 9 Koks S....Vasar E. (2006)
- Gene-environment interaction analysis of serotonin system markers with adolescent depression. (PubMed id 15241435)1, 4, 9 Eley T.C....Craig I.W. (2004)
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External Searches for HTR2C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HTR2C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HTR2C gene
(According to HUGE)
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Specialized Databases showing HTR2C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HTR2C | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HTR2C gene:
Search GeneIP for patents involving HTR2C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HTR2C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for HTR2C | | OriGene shRNA RFP for HTR2C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTR2C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR2C | | | OriGene Protein Over-expression Lysate for HTR2C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HTR2C | | OriGene 3'-UTR Clone for HTR2C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2C |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2C |
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