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HTR2C Gene

protein-coding   GIFtS: 73
GCID: GC0XP113818

5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 2C)
(Previous symbol: HTR1C)
  See HTR2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled1 2     5-HTR2C2 3
HTR1C1 2 3     5-Hydroxytryptamine Receptor 1C2 3
Serotonin Receptor 2C2 3     5-Hydroxytryptamine (Serotonin) Receptor 2C1
5-HT-1C2 3     5-Hydroxytryptamine Receptor 2C2
5-HT-2C2 3     5-Hydroxytryptamine Receptor-1c2
5-HT1C2 3     5HTR2C2
5-HT2C2 3     Serotonin 5-HT-2C Receptor2

External Ids:    HGNC: 52951   Entrez Gene: 33582   Ensembl: ENSG000001472467   OMIM: 3128615   UniProtKB: P283353   

Export aliases for HTR2C gene to outside databases

Previous GC identifers: GC0XP108837 GC0XP110943 GC0XP111854 GC0XP112582 GC0XP113641 GC0XP103403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR2C Gene:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by
binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning,
G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C
subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded
adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second
intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact
with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic
neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of
5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been
found for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for HTR2C Gene:
HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled) is a protein-coding gene. Diseases associated with HTR2C include cyclothymic disorder, and premature ejaculation. GO annotations related to this gene include drug binding and serotonin binding. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
drugs and psychoactive substances, including ergot alkaloid derivatives,
1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a
conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates
the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate
activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger
system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and
promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of
short transient receptor potential calcium channels in the brain, and thereby modulates the activation of
pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role
in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in
insulin sensitivity and glucose homeostasis

summary for HTR2C Gene:
Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid
plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation,
thermoregulation, penile erections and anxiety. The human 5-HT2C receptor gene has been localized to
chromosome X (Xq24).

Gene Wiki entry for HTR2C (5-HT2C receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_028405.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR2C gene promoter:
         MEF-2A   AREB6   MAZR   POU3F1   aMEF-2   CUTL1   AP-2gamma   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR2C promoter sequence
   Search Chromatin IP Primers for HTR2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

HTR2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR2C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP113818:  view genomic region     (about GC identifiers)

Start:
113,818,551 bp from pter      End:
114,144,624 bp from pter
Size:
326,074 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 2C precursor  
Size: 458 amino acids; 51821 Da
Subunit: Interacts with MPDZ. Interacts with ARRB2
Rna editing: Modified_positions=156, 158, 160; Note=Partially edited. RNA editing generates receptor isoforms that
differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line,
suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in
the central nervous system
Secondary accessions: B1AMW4 Q5VUF8 Q9NP28
Alternative splicing: 2 isoforms:  P28335-1   P28335-2   

Explore the universe of human proteins at neXtProt for HTR2C: NX_P28335

Explore proteomics data for HTR2C at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn39
  • Modification sites at PhosphoSitePlus

  • See HTR2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000859.1  NP_001243689.1  NP_001243690.1  

    ENSEMBL proteins: 
     ENSP00000361019   ENSP00000276198   ENSP00000361018  
    Reactome Protein details: P28335

    HTR2C Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant HTR2C Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HTR2C
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    OriGene Custom Protein Services for HTR2C
    GenScript Custom Purified and Recombinant Proteins Services for HTR2C
    Novus Biologicals HTR2C Protein
    Novus Biologicals HTR2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR2C

     
    Search eBioscience for Proteins for HTR2C 

    HTR2C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HTR2C (5-HT2C)
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    Novus Biologicals HTR2C Antibodies
    Abcam antibodies for HTR2C
    Cloud-Clone Corp. Antibodies for HTR2C
    ThermoFisher Antibodies for HTR2C
    LSBio Antibodies in human, mouse, rat for HTR2C

    HTR2C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript HTR2C-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTR2C
    Cloud-Clone Corp. CLIAs for HTR2C
    Search eBioscience for ELISAs for HTR2C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT2C receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000377 5HT2C_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28335

    ProtoNet protein and cluster: P28335

    2 Blocks protein domains:
    IPB000377 5-hydroxytryptamine 2C receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
    Domain: The PDZ domain-binding motif is involved in the interaction with MPDZ
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HTR2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT2C_HUMAN, P28335
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    drugs and psychoactive substances, including ergot alkaloid derivatives,
    1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a
    conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates
    the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate
    activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger
    system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and
    promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of
    short transient receptor potential calcium channels in the brain, and thereby modulates the activation of
    pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role
    in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in
    insulin sensitivity and glucose homeostasis

         Genatlas biochemistry entry for HTR2C:
    5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled
    receptor superfamily,activating the phosphatidylinositol cycle

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001587Gq/11-coupled serotonin receptor activity IDA18703043
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA7582481
    GO:0008144drug binding IDA12970106
    GO:0051378serotonin binding IDA15831837
         
    Find genes that share ontologies with HTR2C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR2C:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Htr2c):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  nervous system  pigmentation 

    Find genes that share phenotypes with HTR2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HTR2C: Htr2ctm1Jul Htr2ctm2Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR2C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTR2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR2C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR2C

    miRNA
    Products:
        
    miRTarBase miRNAs that target HTR2C:
    hsa-mir-22-3p (MIRT005901)

    Block miRNA regulation of human, mouse, rat HTR2C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTR2C (see all 94):
    hsa-miR-4272 hsa-miR-15a hsa-miR-485-3p hsa-miR-3653 hsa-miR-3622b-3p hsa-miR-155* hsa-miR-761 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidHTR2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTR2C
    Predesigned siRNA for gene silencing in human, mouse, rat HTR2C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTR2C

    Clone
    Products:
         
    OriGene clones in human, mouse for HTR2C (see all 7)
    OriGene ORF clones in mouse, rat for HTR2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTR2C (NM_000868)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2C

    Cell Line
    Products:
         
    GenScript HTR2C-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for HTR2C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT2C_HUMAN, P28335: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP18703043
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HTR2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR2C About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90


    Find genes that share SuperPaths with HTR2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HTR2C
        Intracellular Calcium Signaling
    Signaling in Gap Junctions

    1 GeneGo (Thomson Reuters) Pathway for HTR2C
        Transcription Transcription factor Tubby signaling pathways

    3 BioSystems Pathways for HTR2C
        Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR2C
        Serotonin receptors
    G alpha (q) signalling events

    1 PharmGKB Pathway for HTR2C
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for HTR2C):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Serotonergic synapse
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2C: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR2C (P283352, 3 ENSP000002761984) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-73153 MINT-73189 I2D: score=4 STRING: ENSP00000370410
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    LIN7CQ9NUP93, ENSP000002781934I2D: score=2 STRING: ENSP00000278193
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response ISS--
    GO:0006182cGMP biosynthetic process IDA12970106
    GO:0006874cellular calcium ion homeostasis IDA19057895
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IDA12970106

    Find genes that share ontologies with HTR2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HTR2C
    7 ApexBio Compounds for HTR2C     About this table
    CompoundAction CAS #
    Adoprazine5-HT1A receptor agonist properties[222551-17-9]
    Granisetron HCl5-HT3 receptor antagonist[107007-99-8]
    SB 271046 hydrochloridepotent, selective and orally active 5-HT6 receptor antagonist[209481-24-3]
    SEA0400specific Na+/Ca2+ exchange (NCX) inhibitor[223104-29-8]
    Vilazodonecombined SSRI and 5-HT1A receptor partial agonist[163521-12-8]
    Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor[508233-74-7]
    WAY-100635 maleate saltpotent and selective 5-hydroxytryptamine1A antagonist[634908-75-1]

    Compounds for HTR2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 206553 hydrochloride Potent, selective 5-HT2C/5-HT2B antagonist. Orally active [158942-04-2]
    RS 102221 hydrochlorideSelective 5-HT2C antagonist[187397-18-8]
    CP 809101 hydrochloridePotent and selective 5-HT2C agonist[1215721-40-6]
    SB 242084Selective 5-HT2C antagonist; brain penetrant[181632-25-7]
    Ro 60-0175 fumarate Potent, selective 5-HT2C agonist [169675-09-6]

    3 HMDB Compounds for HTR2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--

    Selected DrugBank Compounds for HTR2C (see all 38)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olanzapine-- 132539-06-1targetantagonist10227113 16983399 17624999 11752352 16952163 16336943 16918396
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist16433010 10762339 11271412 9832994 11752352 14615872
    Dexfenfluramine(+)-fenfluramine (see all 3)3239-44-9targetagonist11198050 11888565 12678838 11489456 10353435
    FenfluramineDEA No. 1670 (see all 4)458-24-2targetagonist16973729 16249524 15869562 10617681 12708517
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11103883 7562537 11132243 16918396
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist20426763 10641988 18691132 18992242
    MinaprineMinaprina [INN-Spanish] (see all 4)25905-77-5targetantagonist17139284 2975224 1361012 17016423
    Asenapine-- 65576-45-6targetantagonist21655346 18308814 10592235
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18703043 10641988 18691132
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetantagonist14501155 1296670 9862411

    Selected IUPHAR Ligands for HTR2C (5-HT2C receptor) (see all 94)    About this table
    LigandTypeActionAffinityPubmed IDs
    ritanserin
    AntagonistAntagonist8.2 - 9.615322733
    mesulergine
    AntagonistInverse agonist8.7 - 9.315322733 15107597 12527336
    mianserin
    AntagonistInverse agonist8.3 - 9.215322733 10611634 10217294
    sertindole
    AntagonistInverse agonist9 - 9.212629531 10991983
    methysergide
    AntagonistAntagonist8.6 - 9.115322733 10611640
    SB 228357
    AntagonistAntagonist9 - 9.110188965 10737744
    SB 242084
    AntagonistAntagonist8.2 - 915322733 9225286
    SB 243213
    AntagonistAntagonist910737744
    YM348
    AgonistFull agonist914709324
    FR260010
    AntagonistAntagonist917074317

    Selected Novoseek inferred chemical compound relationships for HTR2C gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agomelatine 84.8 11 17477886 (1), 16687314 (1), 16918076 (1), 16869122 (1) (see all 10)
    mesulergine 83 4 1407010 (1), 2043924 (1), 9166921 (1), 10952674 (1)
    5-hydroxytryptamine 79.3 80 1355262 (4), 10952674 (3), 15242780 (2), 12673575 (2) (see all 30)
    m-chlorophenylpiperazine 74.6 13 7760026 (1), 10870873 (1), 10435401 (1), 15467976 (1) (see all 7)
    maoa 73.4 10 12822741 (1), 15241435 (1), 19566713 (1), 19032968 (1) (see all 8)
    ketanserin 72.9 4 16204332 (1), 17209458 (1), 8584618 (1), 10952674 (1)
    1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 71.2 5 7760026 (1), 8095238 (1), 8780834 (1)
    metergoline 70.6 1 1403790 (1)
    5-carboxamidotryptamine 69.6 2 12588512 (1)
    mianserin 67 3 1403790 (1), 2043924 (1), 2045831 (1)

    5 PharmGKB related drug/compound annotations for HTR2C gene    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    clozapineCA  
    escitalopramCA  
    olanzapineCA  
    risperidoneCA  



    Find genes that share compounds with HTR2C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HTR2C gene (3 alternative transcripts): 
    NM_000868.2  NM_001256760.1  NM_001256761.1  

    Unigene Cluster for HTR2C:

    5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    Hs.149037  [show with all ESTs]
    Unigene Representative Sequence: NM_001256760
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371951 ENST00000276198(uc004epu.1 uc010nqc.1 uc004epv.1)
    ENST00000371950
    miRNA
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    Additional mRNA sequence: 

    AF208053.1 AF498983.1 AK295753.1 AK308766.1 AY114104.1 BC028688.1 BC095543.1 BX648587.1 
    FJ200493.1 M81778.1 U49516.1 

    4 DOTS entries:

    DT.108661  DT.100727990  DT.92416684  DT.92416685 

    20 AceView cDNA sequences:

    Z40928 U49516 AF498983 NM_000868 BG704515 N47111 M81778 BX505080 
    AF208053 CB565884 AW002513 BX118108 BC028688 AI970140 BX648587 N50321 
    CD657722 AI825491 AY114104 CD103423 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                
    SP2:                                      -         


    ECgene alternative splicing isoforms for HTR2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTACAAAG
    HTR2C Expression
    About this image


    HTR2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Testis (Reproductive System)
     
     Brain (Nervous System)
    HTR2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149037

    UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
    Tissue specificity: Detected in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2C: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR2C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr2c1 , 5 5-hydroxytryptamine (serotonin) receptor 2C1, 5 86.29(n)1
    90.59(a)1
      X (68.46 cM)5
    155601  NM_008312.41  NP_032338.31 
     1469625135 
    chicken
    (Gallus gallus)
    Aves HTR2C6
    5-hydroxytryptamine (Serotonin) receptor 2C; Uncha...
    57(a)
    1 ↔ 1
    4(2769656-2802943)
    lizard
    (Anolis carolinensis)
    Reptilia HTR2C6
    5-hydroxytryptamine (serotonin) receptor 2C, G pro...
    57(a)
    1 ↔ 1
    GL343403.1(741181-841254)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ549811.12   -- 72.62(n)    AJ549811.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr2cl26
    htr2cl16
    5-hydroxytryptamine (serotonin) receptor 2C, G pro...
    5-hydroxytryptamine (serotonin) receptor 2C, G pro...
    53(a)
    47(a)
    1 ↔ many
    1 ↔ many
    21(42015230-42022364) ENSDARG00000013210
    7(24524988-24661401) ENSDARG00000018228
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT23 serotonin receptor signaling pathway
    G-protein more
    44(a)   3 82C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33 G-protein coupled receptor 41(a)
    (best of 3)
      X(4985611-4990413)   --


    ENSEMBL Gene Tree for HTR2C (if available)
    TreeFam Gene Tree for HTR2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR2C gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    18 SIMAP similar genes for HTR2C using alignment to 6 protein entries:     5HT2C_HUMAN (see all proteins):
    HTR2B    HTR2A    ADRA1A    ADRA2C    CHRM1    DRD3
    SSTR5    HTR1E    ADRA1B    HTR1D    HTR1F    HTR4
    HTR1B    HTR5A    OPRM1    5HT1A    CHRM2    HTR1A

    Find genes that share paralogs with HTR2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    5HT2C_HUMAN, P28335: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for
    Ser


    Selected SNPs for HTR2C (see all 4734)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs63181,2,,4
    C,F,O,Hnon-pathogenic1113947333(+) GCAATG/CTGATA 6 /S /C mis118Minor allele frequency- C:0.23MN NS EA NA WA CSA 6026
    rs37951821,2
    C,F,H--113798362(+) TCCATA/GTTTAT 3 -- us2k16Minor allele frequency- G:0.13NS EA NA 422
    rs726209061,2
    C--113798616(+) ATGCCC/GCTTTT 3 -- us2k10--------
    rs736384391,2
    C,F--113798633(+) GACTGA/GACAGC 3 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1893118401,2
    C--113798779(+) AACTTC/TGGCCT 3 -- us2k10--------
    rs736384401,2
    C,F--113799200(+) TGCCCA/GGTTGC 3 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1809457601,2
    --113799229(+) AAGAGA/CTCTGC 3 -- us2k10--------
    rs5210181,2
    C,F,A,H--113799452(-) AGACAA/CCTTGA 3 -- us2k117Minor allele frequency- C:0.33NS EA NA WA 1871
    rs1861874641,2
    --113799651(+) TTGCTA/GCTGTT 3 -- us2k10--------
    rs4982071,2
    C,F,O,H--113799660(-) CATTCC/TTCCAA 3 -- us2k125--NA NS EA WA 2885

    HapMap Linkage Disequilibrium report for HTR2C (113818551 - 114068551 bp, first 250kb of HTR2C)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HTR2C (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660156CNV Deletion23128226
    esv1117381CNV Deletion17803354
    esv2740401CNV Deletion23290073
    esv270001CNV Insertion20981092
    esv1501559CNV Insertion17803354
    nsv507990CNV Insertion20534489
    nsv7044CNV Loss18451855
    dgv523n21CNV Loss19592680
    nsv425061CNV Loss16902084
    nsv527347CNV Gain19592680

    Human Gene Mutation Database (HGMD): HTR2C
    Locus Specific Mutation Databases (LSDB): HTR2C

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR2C
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 312861    OMIM disorders: --

    6 diseases for HTR2C:    
    About MalaCards
    cyclothymic disorder    premature ejaculation    generalized anxiety disorder    seasonal affective disorder
    attention deficit hyperactivity disorder    schizophrenia

    3 diseases from the University of Copenhagen DISEASES database for HTR2C:
    Schizophrenia     Cyclothymic disorder     Migraine

    Find genes that share disorders with HTR2C           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HTR2C gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 65.6 27 15717293 (5), 12673575 (2), 14643089 (2), 18855532 (1) (see all 17)
    bipolar disorder 55.8 9 18504633 (2), 19411841 (1), 20015120 (1), 9342201 (1) (see all 6)
    major depression 55.1 9 12853111 (2), 17477886 (1), 19411841 (1), 11526472 (1) (see all 7)
    psychiatric disorder 37.8 18 19411841 (3), 12853111 (3), 20015120 (2), 18379171 (2) (see all 8)
    attention-deficit hyperactivity disorder 37.5 2 14574222 (1), 15303127 (1)
    mood disorders 33.7 3 11526472 (1), 18715570 (1)
    alcoholism 31 7 15304380 (3), 10776672 (2), 14574222 (1), 8612062 (1)
    psychotic 28.6 2 9700207 (1)
    migraine 24.6 11 12555241 (2), 8743744 (1), 15109354 (1), 7622823 (1) (see all 6)
    obesity 22.8 12 17016522 (3), 15048662 (3), 19079077 (1), 15381968 (1) (see all 8)

    Genetic Association Database (GAD): HTR2C
    Human Genome Epidemiology (HuGE) Navigator: HTR2C (140 documents)

    Export disorders for HTR2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR2C gene, integrated from 10 sources (see all 511):
    (articles sorted by number of sources associating them with HTR2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PubMed id 18703043)1, 2, 7 Cussac D....Rauly-Lestienne I. (Eur. J. Pharmacol. 2008)
    2. Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. (PubMed id 10206230)1, 2, 4 Samochowiec J.... Sander T. (Am. J. Med. Genet. 1999)
    3. Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. (PubMed id 7895773)1, 2, 3 Stam N.J.... Olijve W. (Eur. J. Pharmacol. 1994)
    4. Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain. (PubMed id 20015120)1, 4, 9 Bundo M....Kato T. (Psychiatry Clin. Neurosci. 2010)
    5. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. (PubMed id 19142110)1, 4, 9 Gunes A....Dahl M.L. (J Clin Psychopharmacol 2009)
    6. Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients. (PubMed id 18205001)1, 4, 9 Gunes A....Scordo M.G. (Eur. J. Clin. Pharmacol. 2008)
    7. Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample. (PubMed id 20504252)1, 4, 9 Opgen-Rhein C....Dettling M. (Pharmacogenomics 2010)
    8. HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study. (PubMed id 19142101)1, 4, 9 Mulder H....Egberts A.C. (J Clin Psychopharmacol 2009)
    9. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. (PubMed id 15048662)1, 4, 9 Pooley E.C....Harrison P.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    10. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. (PubMed id 17016522)1, 4, 9 Mulder H....Scheffer H. (Pharmacogenomics J. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3358 HGNC: 5295 AceView: HTR2C Ensembl:ENSG00000147246 euGenes: HUgn3358
    ECgene: HTR2C Kegg: 3358 H-InvDB: HTR2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR2C gene:
    Search GeneIP for patents involving HTR2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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