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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR2C Gene

protein-coding   GIFtS: 74
GCID: GC0XP113818

5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 2C)
(Previous symbol: HTR1C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled1 2     5-HTR2C2 3
HTR1C1 2 3     5-Hydroxytryptamine Receptor 1C2 3
Serotonin Receptor 2C2 3     5-Hydroxytryptamine (Serotonin) Receptor 2C1
5-HT-1C2 3     5-Hydroxytryptamine Receptor 2C2
5-HT-2C2 3     5-Hydroxytryptamine Receptor-1c2
5-HT1C2 3     Serotonin 5-HT-2C Receptor2
5-HT2C2 3     

External Ids:    HGNC: 52951   Entrez Gene: 33582   Ensembl: ENSG000001472467   OMIM: 3128615   UniProtKB: P283353   

Export aliases for HTR2C gene to outside databases

Previous GC identifers: GC0XP108837 GC0XP110943 GC0XP111854 GC0XP112582 GC0XP113641 GC0XP103403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR2C Gene:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by
binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning,
G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C
subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded
adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second
intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact
with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic
neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of
5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been
found for this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for HTR2C Gene: 
HTR2C (5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled) is a protein-coding gene. Diseases associated with HTR2C include lingual-facial-buccal dyskinesia, and choroiditis, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include drug binding and serotonin receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association
with G proteins that activate a phosphatidylinositol-calcium second messenger system

summary for HTR2C Gene:
Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid
plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation,
thermoregulation, penile erections and anxiety. The human 5-HT2C receptor gene has been localized to
chromosome X (Xq24).

Gene Wiki entry for HTR2C (5-HT2C receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_028405.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR2C gene promoter:
         MEF-2A   AREB6   MAZR   POU3F1   aMEF-2   CUTL1   AP-2gamma   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR2C promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

HTR2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR2C gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP113818:  view genomic region     (about GC identifiers)

Start:
113,818,551 bp from pter      End:
114,144,624 bp from pter
Size:
326,074 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 2C precursor  
Size: 458 amino acids; 51821 Da
Subunit: Interacts with MPDZ. Interacts with ARRB2
Subcellular location: Cell membrane; Multi-pass membrane protein
Rna editing: Modified_positions=156, 158, 160; Note=Partially edited. RNA editing generates receptor isoforms that
differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line,
suggesting that this RNA processing event may contribute to the modulation of serotonergic neurotransmission in
the central nervous system
Secondary accessions: B1AMW4 Q5VUF8 Q9NP28
Alternative splicing: 2 isoforms:  P28335-1   P28335-2   

Explore the universe of human proteins at neXtProt for HTR2C: NX_P28335

Explore proteomics data for HTR2C at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28335

  • HTR2C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTR2C Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_000859.1  NP_001243689.1  NP_001243690.1  

    ENSEMBL proteins: 
     ENSP00000361019   ENSP00000276198   ENSP00000361018  
    Reactome Protein details: P28335
    Human Recombinant Protein Products for HTR2C: 
    EMD Millipore Purified and/or Recombinant HTR2C Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HTR2C
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HTR2C
    GenScript Custom Purified and Recombinant Proteins Services for HTR2C
    Novus Biologicals HTR2C Protein
    Novus Biologicals HTR2C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR2C 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IMP18703043
    GO:0016021integral to membrane ----

    HTR2C for ontologies           About GeneDecksing



    HTR2C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HTR2C (5-HT2C)
    OriGene Antibodies for HTR2C
    OriGene Custom Antibody Services for HTR2C
    GenScript Custom Superior Antibodies Services for HTR2C
    Novus Biologicals HTR2C Antibodies
    Abcam antibodies for HTR2C
    Cloud-Clone Corp. Antibodies for HTR2C 
    ThermoFisher Antibodies for HTR2C
    LSBio Antibodies in human, mouse, rat for HTR2C 

    Assay Products for HTR2C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HTR2C
    Browse R&D Systems for biochemical assays
    GenScript HTR2C-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTR2C 
    Cloud-Clone Corp. CLIAs for HTR2C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT2C receptor 
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000377 5HT2C_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28335

    ProtoNet protein and cluster: P28335

    2 Blocks protein domains:
    IPB000377 5-hydroxytryptamine 2C receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
    Domain: The PDZ domain-binding motif is involved in the interaction with MPDZ
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT2C_HUMAN, P28335
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association
    with G proteins that activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for HTR2C:
    5-hydroxytryptamine (serotonin) receptor,subtype 2C with two alternatively spliced forms,G protein coupled
    receptor superfamily,activating the phosphatidylinositol cycle

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001587Gq/11-coupled serotonin receptor activity IDA18703043
    GO:0004435phosphatidylinositol phospholipase C activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA7582481
    GO:0008144drug binding IDA12970106
         
    HTR2C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR2C:
     Increased G1 DNA content 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Htr2c):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  nervous system  pigmentation 

    HTR2C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR2C: Htr2ctm1Jul Htr2ctm2Lex

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HTR2C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTR2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR2C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR2C 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HTR2C:
    hsa-mir-22 (MIRT005901)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTR2C
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR2C (see all 94):
    hsa-miR-4272 hsa-miR-15a hsa-miR-485-3p hsa-miR-3653 hsa-miR-3622b-3p hsa-miR-155* hsa-miR-761 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidHTR2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HTR2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTR2C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTR2C
    Sirion Biotech Customized adenovirus for overexpression of HTR2C

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of HTR2C
    OriGene clones in human, mouse for HTR2C (see all 7)
    OriGene ORF clones in mouse, rat for HTR2C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTR2C (NM_000868)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2C
    Sirion Biotech Customized lentivirus for stable overexpression of HTR2C 
                         Customized lentivirus expression plasmids for stable overexpression of HTR2C 

    Cell Line
    Products:
         
    GenScript HTR2C-overexpressing Cell Line for Assay
    Search LifeMap BioReagents cell lines for HTR2C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HTR2C About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.36
    Amine ligand-binding receptors0.79
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics0.33
    3Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HTR2C
        Transcription Transcription factor Tubby signaling pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HTR2C
        Intracellular Calcium Signaling
    Signaling in Gap Junctions

    1 GeneGo (Thomson Reuters) Pathway for HTR2C
        Transcription Transcription factor Tubby signaling pathways

    3 BioSystems Pathways for HTR2C
        Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/9        Reactome Pathways for HTR2C (see all 9)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)

    1 PharmGKB Pathway for HTR2C
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for HTR2C):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Serotonergic synapse


    HTR2C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for HTR2C (P283352, 3 ENSP000002761984) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-73153 MINT-73189 I2D: score=4 STRING: ENSP00000370410
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    LIN7CQ9NUP93, ENSP000002781934I2D: score=2 STRING: ENSP00000278193
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response ISS--
    GO:0006182cGMP biosynthetic process IDA12970106
    GO:0006661phosphatidylinositol biosynthetic process ----
    GO:0006874cellular calcium ion homeostasis IDA19057895
    GO:0007186G-protein coupled receptor signaling pathway ----

    HTR2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR2C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for HTR2C

    Compounds for HTR2C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 206553 hydrochloride Potent, selective 5-HT2C/5-HT2B antagonist. Orally active [158942-04-2]
    RS 102221 hydrochlorideSelective 5-HT2C antagonist[187397-18-8]
    CP 809101 hydrochloridePotent and selective 5-HT2C agonist[1215721-40-6]
    SB 242084Selective 5-HT2C antagonist; brain penetrant[181632-25-7]
    Ro 60-0175 fumarate Potent, selective 5-HT2C agonist [169675-09-6]

    3 HMDB Compounds for HTR2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--

    10/38 DrugBank Compounds for HTR2C (see all 38)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olanzapine-- 132539-06-1targetantagonist10227113 16983399 17624999 11752352 16952163 16336943 16918396
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist16433010 10762339 11271412 9832994 11752352 14615872
    Dexfenfluramine(+)-fenfluramine (see all 3)3239-44-9targetagonist11198050 11888565 12678838 11489456 10353435
    FenfluramineDEA No. 1670 (see all 4)458-24-2targetagonist16973729 16249524 15869562 10617681 12708517
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11103883 7562537 11132243 16918396
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist20426763 10641988 18691132 18992242
    MinaprineMinaprina [INN-Spanish] (see all 4)25905-77-5targetantagonist17139284 2975224 1361012 17016423
    Asenapine-- 65576-45-6targetantagonist21655346 18308814 10592235
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18703043 10641988 18691132
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetantagonist14501155 1296670 9862411

    10/94 IUPHAR Ligands for HTR2C (5-HT2C receptor) (see all 94)    About this table 
    LigandTypeActionAffinityPubmed IDs
    ritanserin
    AntagonistAntagonist8.2 - 9.615322733
    mesulergine
    AntagonistInverse agonist8.7 - 9.315322733 15107597 12527336
    mianserin
    AntagonistInverse agonist8.3 - 9.215322733 10611634 10217294
    sertindole
    AntagonistInverse agonist9 - 9.212629531 10991983
    methysergide
    AntagonistAntagonist8.6 - 9.115322733 10611640
    SB 228357
    AntagonistAntagonist9 - 9.110188965 10737744
    SB 242084
    AntagonistAntagonist8.2 - 915322733 9225286
    SB 243213
    AntagonistAntagonist910737744
    YM348
    AgonistFull agonist914709324
    FR260010
    AntagonistAntagonist917074317

    10/52 Novoseek inferred chemical compound relationships for HTR2C gene (see all 52)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agomelatine 84.8 11 17477886 (1), 16687314 (1), 16918076 (1), 16869122 (1) (see all 10)
    mesulergine 83 4 1407010 (1), 2043924 (1), 9166921 (1), 10952674 (1)
    5-hydroxytryptamine 79.3 80 1355262 (4), 10952674 (3), 15242780 (2), 12673575 (2) (see all 30)
    m-chlorophenylpiperazine 74.6 13 7760026 (1), 10870873 (1), 10435401 (1), 15467976 (1) (see all 7)
    maoa 73.4 10 12822741 (1), 15241435 (1), 19566713 (1), 19032968 (1) (see all 8)
    ketanserin 72.9 4 16204332 (1), 17209458 (1), 8584618 (1), 10952674 (1)
    1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 71.2 5 7760026 (1), 8095238 (1), 8780834 (1)
    metergoline 70.6 1 1403790 (1)
    5-carboxamidotryptamine 69.6 2 12588512 (1)
    mianserin 67 3 1403790 (1), 2043924 (1), 2045831 (1)

    4 PharmGKB related drug/compound annotations for HTR2C gene    About this table
    Drug/compound PharmGKB Annotation
    antipsychoticsCA  
    clozapineCA  
    olanzapineCA  
    risperidoneCA  

    Search CenterWatch for drugs/clinical trials and news about HTR2C / 5HT2C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTR2C gene (3 alternative transcripts): 
    NM_000868.2  NM_001256760.1  NM_001256761.1  

    Unigene Cluster for HTR2C:

    5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    Hs.149037  [show with all ESTs]
    Unigene Representative Sequence: NM_001256760
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371951 ENST00000276198(uc004epu.1 uc010nqc.1 uc004epv.1)
    ENST00000371950

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTR2C
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR2C (see all 94):
    hsa-miR-4272 hsa-miR-15a hsa-miR-485-3p hsa-miR-3653 hsa-miR-3622b-3p hsa-miR-155* hsa-miR-761 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidHTR2C 3' UTR sequence
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    Additional mRNA sequence: 

    AF208053.1 AF498983.1 AK295753.1 AK308766.1 AY114104.1 BC028688.1 BC095543.1 BX648587.1 
    FJ200493.1 M81778.1 U49516.1 

    4 DOTS entries:

    DT.108661  DT.100727990  DT.92416684  DT.92416685 

    20 AceView cDNA sequences:

    AF498983 NM_000868 Z40928 U49516 BX648587 AI970140 BX505080 AW002513 
    BX118108 BC028688 M81778 AF208053 CB565884 N47111 BG704515 N50321 
    CD657722 AI825491 AY114104 CD103423 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HTR2C    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                                                
    SP2:                                      -         


    ECgene alternative splicing isoforms for HTR2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTACAAAG
    HTR2C Expression
    About this image


    See HTR2C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR2C

    SOURCE GeneReport for Unigene cluster: Hs.149037
        SABiosciences Expression via Pathway-Focused PCR Arrays including HTR2C: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HTR2C gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr2c1 , 5 5-hydroxytryptamine (serotonin) receptor 2C1, 5 86.29(n)1
    90.59(a)1
      X (68.46 cM)5
    155601  NM_008312.41  NP_032338.31 
     1469625135 
    chicken
    (Gallus gallus)
    Aves HTR2C1 5-hydroxytryptamine (serotonin) receptor 2C 64.92(n)
    62.79(a)
      428707  XM_426265.3  XP_426265.2 
    lizard
    (Anolis carolinensis)
    Reptilia HTR2C6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    GL343403.1(741181-841254)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ549811.12   -- 72.62(n)    AJ549811.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr2cl11 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like more 60.07(n)
    61.2(a)
      100000981  NM_001129893.1  NP_001123365.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT23 serotonin receptor signaling pathway
    G-protein more
    44(a)   3 82C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33
    ser-11
    G-protein coupled receptor3
    Protein SER-11
    41(a)
    (best of 3)3
    48.75(n)1
    38.12(a)1
      X(4985611-4990413)3
    1817161  NM_001029557.11  NP_001024728.11 


    ENSEMBL Gene Tree for HTR2C (if available)
    TreeFam Gene Tree for HTR2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR2C gene
    HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  
    ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18 SIMAP similar genes for HTR2C using alignment to 6 protein entries:     5HT2C_HUMAN (see all proteins):
    HTR2B    HTR2A    ADRA1A    ADRA2C    CHRM1    DRD3
    SSTR5    HTR1E    ADRA1B    HTR1D    HTR1F    HTR4
    HTR1B    HTR5A    OPRM1    5HT1A    CHRM2    HTR1A

    HTR2C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 5HT2C_HUMAN, P28335
    Polymorphism: Position 23 is polymorphic; the frequencies in unrelated Caucasians are 0.87 for Cys and 0.13 for
    Ser


    10/4734 SNPs in HTR2C are shown (see all 4734)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs63181,2,4
    C,F,O,Hnon-pathogenic1113947333(+) GCAATG/CTGATA 6 /S /C mis118Minor allele frequency- C:0.23MN NS EA NA WA CSA 6026
    VAR_0101664
    ----see VAR_0101662 I V mis40--------
    VAR_0101684
    ----see VAR_0101682 I V mis40--------
    VAR_0101674
    ----see VAR_0101672 N S mis40--------
    rs37951821,2
    C,F,H--113798362(+) TCCATA/GTTTAT 3 -- us2k16Minor allele frequency- G:0.13NS EA NA 422
    rs726209061,2
    C--113798616(+) ATGCCC/GCTTTT 3 -- us2k10--------
    rs736384391,2
    C,F--113798633(+) GACTGA/GACAGC 3 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1893118401,2
    C--113798779(+) AACTTC/TGGCCT 3 -- us2k10--------
    rs736384401,2
    C,F--113799200(+) TGCCCA/GGTTGC 3 -- us2k11Minor allele frequency- G:0.00WA 2
    rs1809457601,2
    --113799229(+) AAGAGA/CTCTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR2C (113818551 - 114068551 bp, first 250kb of HTR2C)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for HTR2C (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660156CNV Deletion23128226
    esv1117381CNV Deletion17803354
    esv2740401CNV Deletion23290073
    esv270001CNV Insertion20981092
    esv1501559CNV Insertion17803354
    nsv507990CNV Insertion20534489
    nsv7044CNV Loss18451855
    dgv523n21CNV Loss19592680
    nsv425061CNV Loss16902084
    nsv527347CNV Gain19592680


    Human Gene Mutation Database (HGMD): HTR2C

    Locus Specific Mutation Databases (LSDB): HTR2C
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 312861    OMIM disorders: --

    20/46 diseases for HTR2C (see all 46):    About MalaCards
    lingual-facial-buccal dyskinesia    choroiditis    premature ejaculation    anxiety disorder
    generalized anxiety disorder    seasonal affective disorder    tardive dyskinesia    borderline personality disorder
    migraine with aura    panic disorder    personality disorder    mental disorders
    attention deficit hyperactivity disorder    bulimia nervosa    migraine    dyspepsia
    cocaine dependence    mood disorder    obsessive-compulsive disorder    anorexia nervosa

    3 diseases from the University of Copenhagen DISEASES database for HTR2C:
    Schizophrenia     Cyclothymic disorder     Migraine

    HTR2C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/19 Novoseek inferred disease relationships for HTR2C gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 65.6 27 15717293 (5), 12673575 (2), 14643089 (2), 18855532 (1) (see all 17)
    bipolar disorder 55.8 9 18504633 (2), 19411841 (1), 20015120 (1), 9342201 (1) (see all 6)
    major depression 55.1 9 12853111 (2), 17477886 (1), 19411841 (1), 11526472 (1) (see all 7)
    psychiatric disorder 37.8 18 19411841 (3), 12853111 (3), 20015120 (2), 18379171 (2) (see all 8)
    attention-deficit hyperactivity disorder 37.5 2 14574222 (1), 15303127 (1)
    mood disorders 33.7 3 11526472 (1), 18715570 (1)
    alcoholism 31 7 15304380 (3), 10776672 (2), 14574222 (1), 8612062 (1)
    psychotic 28.6 2 9700207 (1)
    migraine 24.6 11 12555241 (2), 8743744 (1), 15109354 (1), 7622823 (1) (see all 6)
    obesity 22.8 12 17016522 (3), 15048662 (3), 19079077 (1), 15381968 (1) (see all 8)

    Genetic Association Database (GAD): HTR2C
    Human Genome Epidemiology (HuGE) Navigator: HTR2C (140 documents)

    Export disorders for HTR2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR2C gene, integrated from 9 sources (see all 506):
    (articles sorted by number of sources associating them with HTR2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. (PubMed id 10206230)1, 2, 4 Samochowiec J.... Sander T. (1999)
    2. Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor. (PubMed id 7895773)1, 2, 3 Stam N.J.... Olijve W. (1994)
    3. Mutation screening and assessment of the effect of ge netic variations on expression and RNA editing of serotonin receptor 2C in the human brain. (PubMed id 20015120)1, 4, 9 Bundo M....Kato T. (2010)
    4. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. (PubMed id 19142110)1, 4, 9 Gunes A....Dahl M.L. (2009)
    5. Further evidence for the association between 5-HT2C receptor gene polymorphisms and extrapyramidal side effects in male schizophrenic patients. (PubMed id 18205001)1, 4, 9 Gunes A....Scordo M.G. (2008)
    6. Association of HTR2C, but not LEP or INSIG2, genes wi th antipsychotic-induced weight gain in a German sample. (PubMed id 20504252)1, 4, 9 Opgen-Rhein C....Dettling M. (2010)
    7. HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study. (PubMed id 19142101)1, 4, 9 Mulder H....Egberts A.C. (2009)
    8. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. (PubMed id 15048662)1, 4, 9 Pooley E.C....Harrison P.J. (2004)
    9. The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study. (PubMed id 17016522)1, 4, 9 Mulder H....Scheffer H. (2007)
    10. The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia. (PubMed id 17632216)1, 4, 9 Mulder H....Egberts A.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3358 HGNC: 5295 AceView: HTR2C Ensembl:ENSG00000147246 euGenes: HUgn3358
    ECgene: HTR2C Kegg: 3358 H-InvDB: HTR2C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTR2C gene:
    Search GeneIP for patents involving HTR2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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