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HTR2B Gene

protein-coding   GIFtS: 66
GCID: GC02M231936

5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled1 2     5-HT(2B)2
Serotonin Receptor 2B2 3     5-HT 2B Receptor2
5-HT-2B2 3     5-Hydroxytryptamine 2B Receptor2
5-HT2B2 3     5-Hydroxytryptamine Receptor 2B2
5-Hydroxytryptamine (Serotonin) Receptor 2B1     5-Hydroxytryptamine Receptor 2B Variant B2

External Ids:    HGNC: 52941   Entrez Gene: 33572   Ensembl: ENSG000001359147   OMIM: 6011225   UniProtKB: P415953   

Export aliases for HTR2B gene to outside databases

Previous GC identifers: GC02M230030 GC02M230704 GC02M232175 GC02M231798 GC02M231681 GC02M223815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR2B Gene:
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the
G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a
hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of
serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based
analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this
protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such
as elevated testosterone levels, may also be involved. (provided by RefSeq, Oct 2011)

GeneCards Summary for HTR2B Gene:
HTR2B (5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled) is a protein-coding gene. Diseases associated with HTR2B include heart valve disease, and ocular hypotension. GO annotations related to this gene include drug binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers
signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative
signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the
activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+)
ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release,
5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and
thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of
behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and
normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary
arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and
proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial
cells of Cajal in the intestine

summary for HTR2B Gene:
Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach
fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with little limited distribution in
the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the
embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore,
5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular
hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).

Gene Wiki entry for HTR2B (5-HT2B receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR2B gene promoter:
         Nkx3-1 v4   HSF1 (long)   Nkx3-1 v1   Evi-1   GATA-1   c-Ets-1   Nkx3-1 v2   HSF1short   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR2B promoter sequence
   Search Chromatin IP Primers for HTR2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3-q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q36.3-q37.1

HTR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR2B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M231936:  view genomic region     (about GC identifiers)

Start:
231,972,944 bp from pter      End:
231,989,832 bp from pter
Size:
16,889 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 2B  
Size: 481 amino acids; 54298 Da
Subunit: Interacts with MPDZ
2 PDB 3D structures from and Proteopedia for HTR2B:
4IB4 (3D)        4NC3 (3D)    
Secondary accessions: B2R9D5 Q53TI1 Q62221 Q6P523

Explore the universe of human proteins at neXtProt for HTR2B: NX_P41595

Explore proteomics data for HTR2B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn30

  • See HTR2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000858.3  
    ENSEMBL proteins: 
     ENSP00000258400  
    Reactome Protein details: P41595

    HTR2B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT2B receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000482 5HT2B_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41595

    ProtoNet protein and cluster: P41595

    2 Blocks protein domains:
    IPB000482 5-hydroxytryptamine 2B receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595
    Domain: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT2B_HUMAN, P41595
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers
    signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream
    effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative
    signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the
    activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+)
    ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release,
    5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and
    thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of
    behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and
    normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary
    arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and
    proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial
    cells of Cajal in the intestine

         Genatlas biochemistry entry for HTR2B:
    5-hydroxytryptamine (serotonin) receptor,subtype 2B,G protein coupled receptor superfamily,activating the
    phosphatidylinositol cycle

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IMP15625277
    GO:0004435phosphatidylinositol phospholipase C activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA15862800
    GO:0005099Ras GTPase activator activity ISS--
         
    HTR2B for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Htr2b):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     muscle  normal  reproductive system  skeleton 

    HTR2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr2btm1Lum for HTR2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR2B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR2B

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    SwitchGear 3'UTR luciferase reporter plasmidHTR2B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: HTR2B (NM_000867)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT2B_HUMAN, P41595: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15925089
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0030054cell junction IEA--

    HTR2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR2B About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HTR2B
        Intracellular Calcium Signaling
    Signaling in Gap Junctions

    3 BioSystems Pathways for HTR2B
        Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs


    2 Reactome Pathways for HTR2B
        Serotonin receptors
    G alpha (q) signalling events


    5 Kegg Pathways  (Kegg details for HTR2B):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Serotonergic synapse
    Inflammatory mediator regulation of TRP channels


    HTR2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2B: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR2B (P415952, 3 ENSP000002584004) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-73188 I2D: score=1 STRING: ENSP00000370410
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    GNA11P299923, ENSP000000784294I2D: score=1 STRING: ENSP00000078429
    SNTA1Q134243I2D: score=1 
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001755neural crest cell migration ISS--
    GO:0001819positive regulation of cytokine production IDA19023134
    GO:0001938positive regulation of endothelial cell proliferation IMP19308295
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0003007heart morphogenesis ISS--

    HTR2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    7 ApexBio Compounds for HTR2B     About this table
    CompoundAction CAS #
    Adoprazine5-HT1A receptor agonist properties[222551-17-9]
    Granisetron HCl5-HT3 receptor antagonist[107007-99-8]
    SB 271046 hydrochloridepotent, selective and orally active 5-HT6 receptor antagonist[209481-24-3]
    SEA0400specific Na+/Ca2+ exchange (NCX) inhibitor[223104-29-8]
    Vilazodonecombined SSRI and 5-HT1A receptor partial agonist[163521-12-8]
    Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor[508233-74-7]
    WAY-100635 maleate saltpotent and selective 5-hydroxytryptamine1A antagonist[634908-75-1]

    Compounds for HTR2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BW 723C86 hydrochloride5-HT2B agonist[160521-72-2]
    RS 127445 hydrochloride Selective, high affinity 5-HT2B antagonist [199864-87-4]
    LY 272015 hydrochloride High affinity 5-HT2B antagonist, orally active [172895-15-7]
    SB 204741 Potent, selective 5-HT2B antagonist [152239-46-8]
    alpha-Methyl-5-hydroxytryptamine maleate5-HT2B agonist[304-52-9]

    4 HMDB Compounds for HTR2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    SumatriptanImigran (see all 4)103628-46-2--

    Selected DrugBank Compounds for HTR2B (see all 19)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FenfluramineDEA No. 1670 (see all 4)458-24-2targetagonist12761331 14659797 16960982 11104741 10617681 17202450
    CabergolineCabergolina [Spanish] (see all 2)81409-90-7targetagonist20426763 19570945 10641988 18691132 18992242
    MinaprineMinaprina [INN-Spanish] (see all 4)25905-77-5targetantagonist17139284 2975224 11752352 1361012 17016423
    Triflupromazine-- 146-54-3targetantagonist497523 17139284 11752352 17016423
    BromocriptineBromergocryptine (see all 10)25614-03-3targetagonist18703043 10641988 18691132
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetantagonist14501155 1296670 9862411
    PergolidePergolida [INN-Spanish] (see all 4)66104-22-1targetagonist18703043 10641988 18691132
    TegaserodSDZ HTF 919 (see all 2)189188-57-6targetantagonist16495076 16629860 15466450
    Asenapine-- 65576-45-6targetantagonist21655346 18308814
    ChlorprothixeneAlpha-Chlorprothixene (see all 9)113-59-7targetantagonist17139284 17016423

    Selected IUPHAR Ligands for HTR2B (5-HT2B receptor) (see all 90)    About this table
    LigandTypeActionAffinityPubmed IDs
    RS-127445
    AntagonistAntagonist9 - 9.515322733 10455251
    methysergide
    AgonistPartial agonist8 - 9.415322733 9459568 11104741
    methylergonovine
    AgonistPartial agonist9.315322733 11104741
    methiothepin
    AntagonistAntagonist8.7 - 9.215322733 9459568
    ritanserin
    AntagonistAntagonist8.7 - 9.215322733 10455251 10188965 9459568
    LY53857
    AntagonistAntagonist8.8 - 9.19459568
    (+)-LSD
    AgonistFull agonist915322733
    1-naphthylpiperazine
    AntagonistAntagonist8.4 - 99459568 8078486
    EGIS-7625
    AntagonistAntagonist915107597
    ergotamine
    AgonistPartial agonist8.5 - 8.915322733 11104741

    Selected Novoseek inferred chemical compound relationships for HTR2B gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb204741 93.7 5 15007537 (1), 16629860 (1), 19075042 (1)
    rs102221 83.6 1 19075042 (1)
    m-chlorophenylpiperazine 79.7 4 8856697 (2), 10498829 (1)
    5-hydroxytryptamine 76.3 39 10617681 (3), 19075042 (2), 17950805 (1), 11387323 (1) (see all 11)
    agomelatine 69.2 2 12750432 (1), 16869122 (1)
    tegaserod 68.4 1 16629860 (1)
    ketanserin 67.9 2 15007537 (1), 17209458 (1)
    mcpp 63.8 3 8856697 (2)
    hallucinogen 63.3 1 9933142 (1)
    inositol triphosphate 53.1 1 12970106 (1)



    HTR2B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR2B gene: 
    NM_000867.4  

    Unigene Cluster for HTR2B:

    5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
    Hs.421649  [show with all ESTs]
    Unigene Representative Sequence: BC063123
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000258400(uc010fxv.3 uc002vro.3)
    miRNA
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    Additional mRNA sequence: 

    AK313741.1 AY114103.1 AY136751.1 BC063123.1 X77307.1 Z36748.1 

    1 DOTS entry:

    DT.209532 

    24 AceView cDNA sequences:

    AI245235 AY136751 AI167519 BC063123 BU620850 BQ019778 X77307 N44163 
    BX280117 AY114103 AA588822 AI868853 N36174 NM_000867 AI042025 AL702991 
    Z36748 CD246183 AW299447 H99362 AI264038 BQ301544 AI290224 AW027765 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGACTGTG
    HTR2B Expression
    About this image


    HTR2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced embryoid bodies
    HTR2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421649

    UniProtKB/Swiss-Prot: 5HT2B_HUMAN, P41595
    Tissue specificity: Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at
    lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2B: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr2b1 , 5 5-hydroxytryptamine (serotonin) receptor 2B1, 5 82.74(n)1
    81.63(a)1
      1 (43.94 cM)5
    155591  NM_008311.21  NP_032337.21 
     860990265 
    chicken
    (Gallus gallus)
    Aves HTR2B1 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 73.88(n)
    79.53(a)
      395581  XM_004943362.1  XP_004943419.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR2B6
    5-hydroxytryptamine (serotonin) receptor 2B, G pro...
    77(a)
    1 ↔ 1
    GL343433.1(528759-547330)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr2b1 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 67.92(n)
    70.59(a)
      101731179  XM_004914382.1  XP_004914439.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr2b1 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 63.73(n)
    64.76(a)
      751784  NM_001044743.1  NP_001038208.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT23 serotonin receptor signaling pathway
    G-protein more
    39(a)   3 82C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ser-16
    Protein SER-1, isoform a
    18(a)
    1 → many
    X(16579745-16587462) WBGene00004776


    ENSEMBL Gene Tree for HTR2B (if available)
    TreeFam Gene Tree for HTR2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR2B gene
    HTR2A2  DRD42  DRD22  CHRM12  CHRM22  HRH32  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    13 SIMAP similar genes for HTR2B using alignment to 5 protein entries:     5HT2B_HUMAN (see all proteins):
    HTR2C    HTR2A    CCKBR    ADORA2A    HTR4    HTR5A
    ADRA2C    SSTR5    CHRM1    GPR1    HTR1D    OPRM1
    ADRA1A

    HTR2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    5HT2B_HUMAN, P41595: A variation at a single nucleotide base, which results in an erroneous stop codon and affects
    Gln-20, triggers non-sense mediated RNA decay, such that no HTR2B-receptor protein is expressed. It is associated
    with impulsive behavior and co-segregates with disorders characterized by impulsivity. However, the presence of
    this variant is not in itself sufficient to cause impulsive behavior: male sex, testosterone level, alcohol and
    stress exposure are other factors playing important roles


    4 SNPs for HTR2B    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779829841,2,4
    ----see VAR_0645762 mis40--------
    rs67360171,2,4
    ----see VAR_0559072 mis40--------
    rs784849691,2,4
    ----see VAR_0645742 mis40--------
    rs775700251,2,4
    ----see VAR_0645752 mis40--------

    HapMap Linkage Disequilibrium report for HTR2B (231972944 - 231989832 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HTR2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271896CNV Insertion20981092
    nsv525474CNV Loss19592680
    nsv875957CNV Gain21882294
    nsv524208CNV Gain19592680

    Human Gene Mutation Database (HGMD): HTR2B
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601122    OMIM disorders: --

    Selected diseases for HTR2B (see all 25):    
    About MalaCards
    heart valve disease    ocular hypotension    hepatopulmonary syndrome    chronic fatigue syndrome
    major depressive disorder    obsessive-compulsive disorder    headache    migraine
    uterine fibroid    neuroendocrine tumor    endotheliitis    meningitis
    liver disease    ischemia    obesity    hypertension
    cerebritis    retinitis    tonsillitis    cervicitis


    HTR2B for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HTR2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 18.6 6 8743744 (2), 10563226 (1)
    tumors 0 1 11478272 (1)

    Genetic Association Database (GAD): HTR2B
    Human Genome Epidemiology (HuGE) Navigator: HTR2B (12 documents)

    Export disorders for HTR2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR2B gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with HTR2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. (PubMed id 12970106)1, 2, 7, 9 Schaerlinger B....Maroteaux L. (Br. J. Pharmacol. 2003)
    2. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PubMed id 18703043)1, 2, 7, 9 Cussac D....Rauly-Lestienne I. (Eur. J. Pharmacol. 2008)
    3. Cloning and functional characterization of the human 5-HT2B serotonin receptor. (PubMed id 8143856)1, 2, 3 Schmuck K.... Luebbert H. (FEBS Lett. 1994)
    4. 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. (PubMed id 8882600)1, 2, 9 Ullmer C....LA1bbert H. (Br. J. Pharmacol. 1996)
    5. The human serotonin 5-HT2B receptor: pharmacological link between 5- HT2 and 5-HT1D receptors. (PubMed id 7926008)1, 2, 9 Choi D.S.... Maroteaux L. (FEBS Lett. 1994)
    6. Structural features for functional selectivity at serotonin receptors. (PubMed id 23519215)1, 2 Wacker D....Stevens R.C. (Science 2013)
    7. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    8. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. A population-specific HTR2B stop codon predisposes to severe impulsivity. (PubMed id 21179162)1, 2 Bevilacqua L.... Goldman D. (Nature 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3357 HGNC: 5294 AceView: HTR2B Ensembl:ENSG00000135914 euGenes: HUgn3357
    ECgene: HTR2B Kegg: 3357 H-InvDB: HTR2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HTR2B Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/127

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR2B gene:
    Search GeneIP for patents involving HTR2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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