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HTR2A Gene

protein-coding   GIFtS: 68
GCID: GC13M047407

5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 2A)
(Previous symbol: HTR2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled1 2     5-HT2 Receptor2
HTR21 2 3     5-Hydroxytryptamine Receptor 2A2
5-HT-2A2 3     Serotonin 5-HT-2A Receptor2
5-Hydroxytryptamine (Serotonin) Receptor 2A1     5-HT-23
5-HT2A2     Serotonin Receptor 2A3

External Ids:    HGNC: 52931   Entrez Gene: 33562   Ensembl: ENSG000001024687   OMIM: 1821355   UniProtKB: P282233   

Export aliases for HTR2A gene to outside databases

Previous GC identifers: GC13M045407 GC13M041394 GC13M046344 GC13M045205 GC13M046305 GC13M028201


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR2A Gene:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene
are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated
with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who
also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this
antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for HTR2A Gene:
HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR2A include schizophrenia, and major depressive disorder. GO annotations related to this gene include serotonin receptor activity and protein complex binding. An important paralog of this gene is DRD4.

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane
(DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling
via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling
pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that
modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from
intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of
behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal
smooth muscle contraction, and may play a role in arterial vasoconstriction

summary for HTR2A Gene:
Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex,
caudate nucleus, nucleus accumbens, olfactory tubercle, hippocampus and vascular and non-vascular smooth
muscle cells. 5-HT2A receptors play a role in appetite control, thermoregulation and sleep. 5-HT2A receptors
are also involved, along with various other 5-HT receptor populations, in cardiovascular function and muscle
contraction. The human 5-HT2A receptor gene has been localized to chromosome 13 (13q14-q21).

Gene Wiki entry for HTR2A (5-HT2A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR2A gene promoter:
         Pbx1a   Brachyury   MIF-1   Nkx2-5   S8   POU2F1   Nkx6-1   POU2F1a   c-Myb   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR2A promoter sequence
   Search Chromatin IP Primers for HTR2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14-q21   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14-q21

HTR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR2A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M047407:  view genomic region     (about GC identifiers)

Start:
47,405,685 bp from pter      End:
47,471,169 bp from pter
Size:
65,485 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 2A  
Size: 471 amino acids; 52603 Da
Subunit: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2.
Interacts with GRM2 and DRD2; this may affect signaling
Secondary accessions: B2RAC5 B4DZ79 F5GWE8 Q5T8C0
Alternative splicing: 2 isoforms:  P28223-1   P28223-2   (Ref.5 (BAG63991) sequence is in conflict in position: 49:D->N)

Explore the universe of human proteins at neXtProt for HTR2A: NX_P28223

Explore proteomics data for HTR2A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8, Asn38, Asn44, Asn51, Asn54
  • Modification sites at PhosphoSitePlus

  • See HTR2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000612.1  NP_001159419.1  

    ENSEMBL proteins: 
     ENSP00000367959   ENSP00000441861   ENSP00000437737  
    Reactome Protein details: P28223

    HTR2A Human Recombinant Protein Products:

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    GenScript HTR2A-overexpressing Cell Line for Assay
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    Cloud-Clone Corp. ELISAs for HTR2A
    Cloud-Clone Corp. CLIAs for HTR2A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT2A receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000455 5HT2A_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28223

    ProtoNet protein and cluster: P28223

    2 Blocks protein domains:
    IPB000455 5-hydroxytryptamine 2A receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223
    Domain: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT2A_HUMAN, P28223
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane
    (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling
    via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
    Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling
    pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that
    modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from
    intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of
    behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal
    smooth muscle contraction, and may play a role in arterial vasoconstriction

         Genatlas biochemistry entry for HTR2A:
    5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating the
    phosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated with
    schizophrenia

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA15862800
    GO:0005515protein binding ----
    GO:0008144drug binding IDA15831837
         
    HTR2A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Htr2a):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  muscle  skeleton 

    HTR2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR2A: Htr2atm1Rhn Htr2atm2Grch Htr2atm1Grch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR2A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR2A

    miRNA
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    Block miRNA regulation of human, mouse, rat HTR2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTR2A (see all 16):
    hsa-miR-203 hsa-miR-3163 hsa-miR-767-3p hsa-miR-4251 hsa-miR-15a hsa-miR-3942-5p hsa-miR-218-1* hsa-miR-497
    SwitchGear 3'UTR luciferase reporter plasmidHTR2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTR2A
    Predesigned siRNA for gene silencing in human, mouse, rat HTR2A

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for HTR2A

    Clone
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    OriGene clones in human, mouse for HTR2A (see all 11)
    OriGene ORF clones in mouse, rat for HTR2A
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    GenScript: all cDNA clones in your preferred vector (see all 2): HTR2A (NM_000621)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2A

    Cell Line
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    GenScript HTR2A-overexpressing Cell Line for Assay
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT2A_HUMAN, P28223: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite (By similarity). Cell
    projection, axon (By similarity). Cytoplasmic vesicle (By similarity). Membrane, caveola (By similarity).
    Note=Localizes to the postsynaptic thickening of axo-dendritic synapses (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0005901caveola IEA--

    HTR2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR2A About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HTR2A
        Intracellular Calcium Signaling
    Signaling in Gap Junctions

    Selected BioSystems Pathways for HTR2A (see all 6)
        Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    SIDS Susceptibility Pathways
    Serotonin Receptor 2 and STAT3 Signaling
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for HTR2A
        Serotonin receptors
    G alpha (q) signalling events

    1 PharmGKB Pathway for HTR2A
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for HTR2A):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Serotonergic synapse
    Inflammatory mediator regulation of TRP channels


    HTR2A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2A: 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR2A (P282232, 3 ENSP000003679594) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-73187 I2D: score=1 STRING: ENSP00000370410
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    ANKS1BQ7Z6G83, ENSP000003313814I2D: score=1 STRING: ENSP00000331381
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    GLULP151043, ENSP000003079004I2D: score=1 STRING: ENSP00000307900
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0006874cellular calcium ion homeostasis IDA16517693
    GO:0006939smooth muscle contraction ----
    GO:0006950response to stress ----
    GO:0007186G-protein coupled receptor signaling pathway ----

    HTR2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HTR2A
    7 ApexBio Compounds for HTR2A     About this table
    CompoundAction CAS #
    Adoprazine5-HT1A receptor agonist properties[222551-17-9]
    Granisetron HCl5-HT3 receptor antagonist[107007-99-8]
    SB 271046 hydrochloridepotent, selective and orally active 5-HT6 receptor antagonist[209481-24-3]
    SEA0400specific Na+/Ca2+ exchange (NCX) inhibitor[223104-29-8]
    Vilazodonecombined SSRI and 5-HT1A receptor partial agonist[163521-12-8]
    Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor[508233-74-7]
    WAY-100635 maleate saltpotent and selective 5-hydroxytryptamine1A antagonist[634908-75-1]

    Compounds for HTR2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Risperidone5-HT2A antagonist[106266-06-2]
    Mesulergine hydrochloride5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist[64795-35-3]
    Ketanserin tartrateSelective 5-HT2A antagonist. Also antagonist at 5-HT1D[83846-83-7]
    TCB-2 Potent, high affinity 5-HT2A agonist [912342-28-0]
    AT 1015Long-acting 5-HT2A antagonist[190508-50-0]

    8 HMDB Compounds for HTR2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    CalciumCa (see all 2)7440-70-2--
    DonepezilAricept (see all 3)120014-06-4--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    RisperidoneBelivon (see all 7)106266-06-2--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    VenlafaxineEfectin (see all 6)93413-69-5--

    Selected DrugBank Compounds for HTR2A (see all 66)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olanzapine-- 132539-06-1targetantagonist10227113 15358979 16905159 15816787 17848919 11752352 17316700 14530903 16038601
    NefazodoneNefazodona [Spanish] (see all 4)83366-66-9targetantagonist10435395 7855217 9098663 10220119 14520130 7649970 10577608 12873632
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 15121646 12530423 12445705 17450180 17848919 11509214
    Clozapine-- 5786-21-0targetantagonist14687870 14751426 12973385 7520908 14530903 15037867
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist10446735 10446738 11607047 11063897 10451911 10446734
    Paliperidone-- 144598-75-4targetantagonist12211096 7542676 7520908 7531353 7524043 11132243
    TrazodoneTrazodona [INN-Spanish] (see all 4)19794-93-5targetantagonist11714900 15610924 7855217 3039120 10594316 1365657
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetantagonist14501155 9862411 1296670 8558452 10682715
    Cyproheptadine-- 129-03-3targetantagonist12233819 1403790 1358088 16418149 12498911
    MMDA(+-)-mmda (see all 7)13674-05-0targetagonist17209801 9666084 10987842 17139284 17016423

    Selected IUPHAR Ligands for HTR2A (5-HT2A receptor) (see all 112)    About this table
    LigandTypeActionAffinityPubmed IDs
    risperidone
    AntagonistInverse agonist9.3 - 108935801 12629531 12176106
    AC-90179
    AntagonistInverse agonist9.715102927
    [3H]ketanserin
    AntagonistAntagonist8.6 - 9.715322733 12738034
    ketanserin
    AntagonistAntagonist8.1 - 9.715322733 8845011 12738034
    mianserin
    AntagonistAntagonist7.7 - 9.615322733 15107597 10611634
    asenapine
    AgonistFull agonist9.68935801
    ziprasidone
    AntagonistAntagonist8.8 - 9.58935801 12629531 12176106
    spiperone
    AntagonistAntagonist7.8 - 9.415322733 2233697 8534270
    LSD
    AgonistFull agonist9.48663249
    methylergonovine
    AgonistFull agonist9.415322733

    Selected Novoseek inferred chemical compound relationships for HTR2A gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ketanserin 93.4 154 1479590 (4), 19879056 (2), 8388988 (2), 7707322 (2) (see all 99)
    5-hydroxytryptamine 89.4 339 1355262 (7), 18430065 (5), 1560366 (3), 9384503 (3) (see all 99)
    ritanserin 86.3 50 15787439 (2), 7902766 (2), 2117764 (2), 1536032 (2) (see all 42)
    1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 84.1 18 1769371 (1), 7813581 (1), 7760026 (1), 8825354 (1) (see all 17)
    methiothepin 83.7 13 10374714 (1), 1425972 (1), 1393286 (1), 2086249 (1) (see all 12)
    mesulergine 82.1 7 11230991 (1), 1644189 (1), 1525017 (1), 1435740 (1) (see all 7)
    setoperone 81.8 4 10401447 (1), 7687976 (1), 10435604 (1)
    5-carboxamidotryptamine 81.4 9 8825354 (1), 9522163 (1), 8786274 (1), 1849768 (1) (see all 7)
    spiperone 79.3 25 11078195 (1), 2164094 (1), 8577395 (1), 2068047 (1) (see all 21)
    clozapine 78.7 99 20521326 (4), 19142110 (4), 9989565 (3), 7573582 (3) (see all 56)

    7 PharmGKB related drug/compound annotations for HTR2A gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    citalopramCA  
    escitalopramCA  
    olanzapineCA  
    risperidoneCA  
    venlafaxineCA  



    HTR2A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR2A gene (2 alternative transcripts): 
    NM_000621.4  NM_001165947.2  

    Unigene Cluster for HTR2A:

    5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
    Hs.72630  [show with all ESTs]
    Unigene Representative Sequence: NM_000621
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378688 ENST00000543956(uc001vbr.3) ENST00000542664(uc010acr.3)

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    Additional mRNA sequence: 

    AF498982.1 AK302787.1 AK314132.1 BC069356.1 BC069576.1 BC074848.2 BC074849.2 BC096839.1 
    BX647777.1 M86841.1 S71229.1 X57830.1 

    4 DOTS entries:

    DT.456099  DT.209624  DT.305223  DT.95108653 

    22 AceView cDNA sequences:

    BC074848 BC069576 AI379882 BC074849 BX108650 BC069356 S71229 AF498982 
    AI565418 AW117542 CA393776 M86841 AA954285 NM_000621 CB565885 X57830 
    BX647777 BG703062 AI005152 CD105069 AA166934 AA166746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR2A Expression
    About this image


    HTR2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
    HTR2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72630

    UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223
    Tissue specificity: Detected in brain cortex (at protein level). Detected in blood platelets

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR2A: 
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              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr2a1 , 5 5-hydroxytryptamine (serotonin) receptor 2A1, 5 87.54(n)1
    91.51(a)1
      14 (39.37 cM)5
    155581  NM_172812.21  NP_766400.11 
     746408405 
    chicken
    (Gallus gallus)
    Aves HTR2A1 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled less 75.23(n)
    77.73(a)
      428070  XM_004938700.1  XP_004938757.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR2A6
    5-hydroxytryptamine (serotonin) receptor 2A, G pro...
    70(a)
    1 ↔ 1
    1(137032501-137053331)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr2a1 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled less 70.6(n)
    75.5(a)
      100492782  XM_002935113.1  XP_002935159.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-276l13.41 si:dkey-276l13.4 67.12(n)
    70.41(a)
      559806  XM_683178.3  XP_688270.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT23 serotonin receptor signaling pathway
    G-protein coupled serotonin receptor less
    42(a)   3 82C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ser-11 ser-1 48.73(n)
    36.7(a)
      181716  NM_001029557.2  NP_001024728.1 


    ENSEMBL Gene Tree for HTR2A (if available)
    TreeFam Gene Tree for HTR2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR2A gene
    DRD42  DRD22  CHRM12  CHRM22  HRH32  HTR2B2  HRH42  HTR2C2  
    HRH12  CHRM52  DRD32  CHRM42  CHRM32  
    Selected SIMAP similar genes for HTR2A using alignment to 6 protein entries:     5HT2A_HUMAN (see all proteins) (see all similar genes):
    HTR2B    GHSR    ADORA2A    HTR2C    ADRA1A    ADRA2C
    CCKBR    CHRM2    DRD3    HTR5A    CHRM1    HTR1B
    HTR1D    HTR1F    HTR6    HTR7    ADRA1B    HTR1E

    HTR2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR2A (see all 1430)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394728491,2
    Cuntested128352860(+) AGGGCC/G/TCCAAT 4 G syn10--------
    rs745958071,2
    C--28247715(+) AAAAAA/CAAAAA 2 -- int10--------
    rs1501531041,2
    --28349082(+) GGATCA/CTAGCT 2 -- ds50010--------
    rs1123220001,2
    C,F--28349129(+) TTGCTC/GTCGAA 2 -- ds50012Minor allele frequency- G:0.07CSA WA 120
    rs1850794201,2
    --28349151(+) TACCTA/GGAGTT 2 -- ds50010--------
    rs1159554271,2
    C,F--28349160(+) TTCTGA/CGTCTG 2 -- ds50010--------
    rs1403735541,2
    --28349192(+) AATTCC/TGTTTA 2 -- ds50010--------
    rs766650581,2
    C,F--28349210(+) CAGCTA/GTGGAC 2 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1455790641,2
    C--28349271(+) CCTTTC/GTTGAA 2 -- ut310--------
    rs619483071,2
    C--28349285(+) TTTTAG/ACATCG 2 -- ut312Minor allele frequency- A:0.07NA 122

    HapMap Linkage Disequilibrium report for HTR2A (47405685 - 47471169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HTR2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1027CNV Insertion18451855
    nsv900063CNV Loss21882294
    nsv510334CNV Loss20534489

    Human Gene Mutation Database (HGMD): HTR2A
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 182135   
    OMIM disorders: 181500  164230  608516  103780  606788  
    Selected diseases for HTR2A (see all 129):    
    About MalaCards
    schizophrenia    major depressive disorder    anorexia nervosa    alcohol dependence
    major depressive disorder, response to citalopram therapy in    akinetopsia    dysthymic disorder    seasonal affective disorder
    chronic cervicitis    thromboangiitis obliterans    schizoaffective disorder    alcoholic psychosis
    intermittent claudication    heart valve disease    obsessive-compulsive disorder    sleep apnea
    serotonin syndrome    tic disorder    psychotic disorder    fibromyalgia

    6 diseases from the University of Copenhagen DISEASES database for HTR2A:
    Schizophrenia     Attention deficit hyperactivity disorder     Alcohol dependence     Cyclothymic disorder
    Schizoaffective disorder     Antisocial personality disorder

    HTR2A for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HTR2A gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 76.8 166 19855357 (5), 14744462 (3), 17069769 (3), 16405867 (3) (see all 99)
    major depression 64.3 29 11311507 (3), 2310804 (2), 19428704 (2), 7865496 (2) (see all 21)
    mood disorders 57.3 35 10758249 (3), 11992560 (3), 17884017 (3), 19428704 (2) (see all 20)
    psychotic 56.2 18 10686558 (2), 18712714 (1), 10087520 (1), 10192823 (1) (see all 11)
    obsessive-compulsive disorder 53.5 19 11239910 (3), 18339223 (2), 1624756 (1), 12476319 (1) (see all 11)
    bipolar disorder 50.7 25 9341875 (4), 19584773 (4), 12622403 (2), 11093065 (2) (see all 14)
    catalepsy 49.8 3 10188965 (1), 8935798 (1)
    schizoaffective disorder 47.7 4 20521326 (1), 19142110 (1), 15121646 (1), 17500207 (1)
    migraine 45.3 25 8675433 (5), 2045831 (4), 1871321 (1), 1337765 (1) (see all 14)
    psychiatric disorder 44.9 12 17691947 (3), 7911139 (1), 7542676 (1), 19004992 (1) (see all 8)

    Genetic Association Database (GAD): HTR2A
    Human Genome Epidemiology (HuGE) Navigator: HTR2A (387 documents)

    Export disorders for HTR2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR2A gene, integrated from 10 sources (see all 1668):
    (articles sorted by number of sources associating them with HTR2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PubMed id 18703043)1, 2, 7, 9 Cussac D....Rauly-Lestienne I. (Eur. J. Pharmacol. 2008)
    2. Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. (PubMed id 15037867)1, 4, 7 Reist C....Goldman D. (Mol. Psychiatry 2004)
    3. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. (PubMed id 8655141)1, 2, 4 Erdmann J....Noethen M.M. (Hum. Genet. 1996)
    4. Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. (PubMed id 8035173)1, 2, 3 Cook E.H. Jr....Leventhal B.L. (J. Neurochem. 1994)
    5. Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes. (PubMed id 19647026)1, 4, 9 Guhathakurta S....Usha R. (Neurochem. Int. 2009)
    6. Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. (PubMed id 17102980)1, 4, 9 Gunes A....Dahl M.L. (Psychopharmacology (Berl.) 2007)
    7. 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. (PubMed id 15048642)1, 4, 9 Zhang X.N....Zhang L.N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    8. HTR2A variation and sudden infant death syndrome: a case-control analysis. (PubMed id 18771483)1, 4, 9 Rand C.M....Weese-Mayer D.E. (Acta Paediatr. 2009)
    9. Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients. (PubMed id 19855357)1, 4, 9 Melkersson K. and Hulting A.L. (Neuro Endocrinol. Lett. 2009)
    10. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. (PubMed id 19142110)1, 4, 9 Gunes A....Dahl M.L. (J Clin Psychopharmacol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3356 HGNC: 5293 AceView: HTR2A Ensembl:ENSG00000102468 euGenes: HUgn3356
    ECgene: HTR2A Kegg: 3356 H-InvDB: HTR2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR2A Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HTR2A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR2A gene:
    Search GeneIP for patents involving HTR2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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