Aliases for HTR2A Gene
External Ids for HTR2A Gene
Previous HGNC Symbols for HTR2A Gene
Previous GeneCards Identifiers for HTR2A Gene
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
GeneCards Summary for HTR2A Gene
HTR2A (5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR2A include anorexia nervosa and schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include protein complex binding and serotonin receptor activity. An important paralog of this gene is CHRM4.
UniProtKB/Swiss-Prot for HTR2A Gene
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, olfactory tubercle, hippocampus and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in appetite control, thermoregulation and sleep. 5-HT2A receptors are also involved, along with various other 5-HT receptor populations, in cardiovascular function and muscle contraction. The human 5-HT2A receptor gene has been localized to chromosome 13 (13q14-q21).