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Aliases for HTR2A Gene

Aliases for HTR2A Gene

  • 5-Hydroxytryptamine Receptor 2A 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled 2 3 5
  • HTR2 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2A 2
  • Serotonin 5-HT-2A Receptor 3
  • Serotonin Receptor 2A 4
  • 5-HT2 Receptor 3
  • 5-HT-2A 4
  • 5-HT2A 3
  • 5-HT-2 4

External Ids for HTR2A Gene

Previous HGNC Symbols for HTR2A Gene

  • HTR2

Previous GeneCards Identifiers for HTR2A Gene

  • GC13M045407
  • GC13M041394
  • GC13M046344
  • GC13M045205
  • GC13M046305
  • GC13M047407
  • GC13M028201

Summaries for HTR2A Gene

Entrez Gene Summary for HTR2A Gene

  • This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for HTR2A Gene

HTR2A (5-Hydroxytryptamine Receptor 2A) is a Protein Coding gene. Diseases associated with HTR2A include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment and Anorexia Nervosa 1. Among its related pathways are Peptide ligand-binding receptors and Serotonin Receptor 2 and ELK-SRF/GATA4 signaling. GO annotations related to this gene include G-protein coupled receptor activity and drug binding. An important paralog of this gene is HTR2C.

UniProtKB/Swiss-Prot for HTR2A Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

  • (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.

Tocris Summary for HTR2A Gene

  • Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, hippocampus, and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in the control of appetite.

Gene Wiki entry for HTR2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2A Gene

Genomics for HTR2A Gene

Regulatory Elements for HTR2A Gene

Enhancers for HTR2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTR2A on UCSC Golden Path with GeneCards custom track

Promoters for HTR2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HTR2A on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR2A Gene

Chromosome:
13
Start:
46,831,542 bp from pter
End:
46,897,076 bp from pter
Size:
65,535 bases
Orientation:
Minus strand

Genomic View for HTR2A Gene

Genes around HTR2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2A Gene

Proteins for HTR2A Gene

  • Protein details for HTR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28223-5HT2A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2A
    Protein Accession:
    P28223
    Secondary Accessions:
    • B2RAC5
    • B4DZ79
    • F5GWE8
    • Q5T8C0

    Protein attributes for HTR2A Gene

    Size:
    471 amino acids
    Molecular mass:
    52603 Da
    Quaternary structure:
    • Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.

    Alternative splice isoforms for HTR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2A Gene

Proteomics data for HTR2A Gene at MOPED

Post-translational modifications for HTR2A Gene

  • Glycosylation at Asn 8, Asn 38, Asn 44, Asn 51, and Asn 54
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR2A Gene

No data available for DME Specific Peptides for HTR2A Gene

Domains & Families for HTR2A Gene

Graphical View of Domain Structure for InterPro Entry

P28223

UniProtKB/Swiss-Prot:

5HT2A_HUMAN :
  • The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2A: view

Function for HTR2A Gene

Molecular function for HTR2A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated with schizophrenia
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.
genes like me logo Genes that share phenotypes with HTR2A: view

Animal Models for HTR2A Gene

MGI Knock Outs for HTR2A:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR2A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR2A Gene

Localization for HTR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2A Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2A Gene COMPARTMENTS Subcellular localization image for HTR2A gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 3
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
vacuole 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005901 caveola IEA --
GO:0016020 membrane IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with HTR2A: view

Pathways & Interactions for HTR2A Gene

genes like me logo Genes that share pathways with HTR2A: view

Gene Ontology (GO) - Biological Process for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0006939 smooth muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS 9109547
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with HTR2A: view

No data available for SIGNOR curated interactions for HTR2A Gene

Drugs & Compounds for HTR2A Gene

(260) Drugs for HTR2A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Risperidone Approved, Investigational Pharma Antagonist, antagonist, Target SR-2A inhibitor 477
Olanzapine Approved, Investigational Pharma Antagonist, agonist, Target, antagonist 380
Aripiprazole Approved, Investigational Pharma Antagonist, agonist, Target, antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 343
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Lisuride Approved Pharma Antagonist, agonist, Target 5

(55) Additional Compounds for HTR2A Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>11</sup>C]MDL100907
<i>m</i>-CPP
Antagonist
5-HT
Full agonist, Agonist
alpha-methyl-5-HT
Full agonist, Agonist
AMI-193
Antagonist

(5) Tocris Compounds for HTR2A Gene

Compound Action Cas Number
Clozapine Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 5786-21-0
DOI hydrochloride Mixed 5-HT2A/2C agonist 42203-78-1
NBOH-2C-CN hydrochloride High affinity, selective 5-HT2A agonist 1539266-32-4
PNU 22394 hydrochloride 5-HT2C agonist and 5-HT2A/2B partial agonist 15923-42-9
TCB-2 Potent, high affinity 5-HT2A agonist 912342-28-0

(44) ApexBio Compounds for HTR2A Gene

Compound Action Cas Number
Amitriptyline HCl Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor 549-18-8
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Duloxetine HCl 136434-34-9
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist 133454-47-4
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
Loxapine Succinate 27833-64-3
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
LY310762 192927-92-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
Naratriptan 143388-64-1
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Palonosetron HCl 135729-62-3
Penfluridol 26864-56-2
Pizotifen Malate 5189-11-7
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective 866206-55-5
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
RS 127445 5-HT2B receptor antagonist,high affinity 199864-87-4
SB271046 209481-20-9
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR2A: view

Drug Products

Transcripts for HTR2A Gene

mRNA/cDNA for HTR2A Gene

Unigene Clusters for HTR2A Gene

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2A Gene

No ASD Table

Relevant External Links for HTR2A Gene

GeneLoc Exon Structure for
HTR2A
ECgene alternative splicing isoforms for
HTR2A

Expression for HTR2A Gene

mRNA expression in normal human tissues for HTR2A Gene

mRNA differential expression in normal tissues according to GTEx for HTR2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.3), Brain - Anterior cingulate cortex (BA24) (x8.5), and Brain - Cortex (x7.6).

Protein differential expression in normal tissues from HIPED for HTR2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR2A Gene



SOURCE GeneReport for Unigene cluster for HTR2A Gene Hs.72630

mRNA Expression by UniProt/SwissProt for HTR2A Gene

P28223-5HT2A_HUMAN
Tissue specificity: Detected in brain cortex (at protein level). Detected in blood platelets.
genes like me logo Genes that share expression patterns with HTR2A: view

Protein tissue co-expression partners for HTR2A Gene

- Elite partner

Primer Products

Orthologs for HTR2A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR2A 35
  • 90.35 (n)
  • 94.47 (a)
HTR2A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR2A 35
  • 89.22 (n)
  • 93.83 (a)
mouse
(Mus musculus)
Mammalia Htr2a 35
  • 87.54 (n)
  • 91.51 (a)
Htr2a 16
Htr2a 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR2A 35
  • 99.29 (n)
  • 99.79 (a)
HTR2A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2a 35
  • 87.47 (n)
  • 91.3 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR2A 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR2A 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR2A 35
  • 75.23 (n)
  • 77.73 (a)
HTR2A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2A 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr2a 35
  • 70.6 (n)
  • 75.5 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-276l13.4 35
  • 67.12 (n)
  • 70.41 (a)
htr2a 36
  • 66 (a)
OneToMany
HTR2A (2 of 2) 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT2 37
  • 42 (a)
5-HT2 36
  • 16 (a)
ManyToMany
CG42796 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ser-1 35
  • 48.73 (n)
  • 36.7 (a)
ser-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for HTR2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR2A Gene

ENSEMBL:
Gene Tree for HTR2A (if available)
TreeFam:
Gene Tree for HTR2A (if available)

Paralogs for HTR2A Gene

Paralogs for HTR2A Gene

genes like me logo Genes that share paralogs with HTR2A: view

Variants for HTR2A Gene

Sequence variations from dbSNP and Humsavar for HTR2A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1805055 - 46,895,833(-) TGACA(A/C/G)CAGGC intron-variant, reference, missense
rs6314 - 46,834,899(-) AGCAG(C/T)ATTCT reference, missense
rs6304 - 46,892,414(-) AAATC(A/G)TTGCT reference, missense
rs6308 - 46,834,913(-) GGTTG(C/T)TCTAG reference, missense
rs3125 -- 46,834,716(-) TATCT(C/G)TATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR2A Gene

Variant ID Type Subtype PubMed ID
nsv1027 CNV Insertion 18451855
nsv900063 CNV Loss 21882294
nsv510334 CNV Loss 20534489

Variation tolerance for HTR2A Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.11; 61.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR2A Gene

Human Gene Mutation Database (HGMD)
HTR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2A Gene

Disorders for HTR2A Gene

MalaCards: The human disease database

(171) MalaCards diseases for HTR2A Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
anorexia nervosa 1
  • anorexia nervosa
schizophrenia
  • schizophrenia 12
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search HTR2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR2A

Genetic Association Database (GAD)
HTR2A
Human Genome Epidemiology (HuGE) Navigator
HTR2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR2A
genes like me logo Genes that share disorders with HTR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2A Gene

Publications for HTR2A Gene

  1. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. (PMID: 8655141) Erdmann J. … Noethen M.M. (Hum. Genet. 1996) 3 4 48 67
  2. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D. … Rauly-Lestienne I. (Eur. J. Pharmacol. 2008) 3 25 26
  3. Effect of cyproheptadine on serum leptin levels. (PMID: 16418149) Calka O. … ErkoAs R. (Adv Ther 2005) 23 25 26
  4. A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone. (PMID: 15121646) Mamo D. … Remington G. (Am J Psychiatry 2004) 23 25 26
  5. Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial. (PMID: 14520130) Avila A. … Bello J. (J Clin Psychopharmacol 2003) 23 25 26

Products for HTR2A Gene

Sources for HTR2A Gene

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