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Aliases for HTR2A Gene

Aliases for HTR2A Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled 2 3
  • 5-HT-2A 3 4
  • HTR2 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 2A 2
  • 5-Hydroxytryptamine Receptor 2A 3
  • Serotonin 5-HT-2A Receptor 3
  • Serotonin Receptor 2A 4
  • 5-HT2 Receptor 3
  • 5-HT2A 3
  • 5-HT-2 4

External Ids for HTR2A Gene

Previous HGNC Symbols for HTR2A Gene

  • HTR2

Previous GeneCards Identifiers for HTR2A Gene

  • GC13M045407
  • GC13M041394
  • GC13M046344
  • GC13M045205
  • GC13M046305
  • GC13M047407
  • GC13M028201

Summaries for HTR2A Gene

Entrez Gene Summary for HTR2A Gene

  • This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for HTR2A Gene

HTR2A (5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR2A include anorexia nervosa and schizophrenia. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include protein complex binding and serotonin receptor activity. An important paralog of this gene is CHRM4.

UniProtKB/Swiss-Prot for HTR2A Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Tocris Summary for HTR2A Gene

  • Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, olfactory tubercle, hippocampus and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in appetite control, thermoregulation and sleep. 5-HT2A receptors are also involved, along with various other 5-HT receptor populations, in cardiovascular function and muscle contraction. The human 5-HT2A receptor gene has been localized to chromosome 13 (13q14-q21).

Gene Wiki entry for HTR2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR2A Gene

Genomics for HTR2A Gene

Regulatory Elements for HTR2A Gene

Genomic Location for HTR2A Gene

Start:
46,831,542 bp from pter
End:
46,897,076 bp from pter
Size:
65,535 bases
Orientation:
Minus strand

Genomic View for HTR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR2A Gene

Proteins for HTR2A Gene

  • Protein details for HTR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28223-5HT2A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 2A
    Protein Accession:
    P28223
    Secondary Accessions:
    • B2RAC5
    • B4DZ79
    • F5GWE8
    • Q5T8C0

    Protein attributes for HTR2A Gene

    Size:
    471 amino acids
    Molecular mass:
    52603 Da
    Quaternary structure:
    • Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.

    Alternative splice isoforms for HTR2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTR2A Gene

Proteomics data for HTR2A Gene at MOPED

Post-translational modifications for HTR2A Gene

  • Glycosylation at Asn8, Asn38, Asn44, Asn51, and Asn54
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR2A Gene

Domains for HTR2A Gene

Graphical View of Domain Structure for InterPro Entry

P28223

UniProtKB/Swiss-Prot:

5HT2A_HUMAN :
  • The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR2A: view

Function for HTR2A Gene

Molecular function for HTR2A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating the phosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated with schizophrenia
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Gene Ontology (GO) - Molecular Function for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IEA --
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 15862800
GO:0005515 protein binding --
GO:0008144 drug binding IDA 15831837
genes like me logo Genes that share ontologies with HTR2A: view
genes like me logo Genes that share phenotypes with HTR2A: view

Animal Models for HTR2A Gene

MGI Knock Outs for HTR2A:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HTR2A Gene

Localization for HTR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR2A Gene

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Note=Localizes to the postsynaptic thickening of axo-dendritic synapses. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR2A Gene COMPARTMENTS Subcellular localization image for HTR2A gene
Compartment Confidence
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005901 caveola IEA --
genes like me logo Genes that share ontologies with HTR2A: view

Pathways for HTR2A Gene

genes like me logo Genes that share pathways with HTR2A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HTR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0006874 cellular calcium ion homeostasis IDA 16517693
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007202 activation of phospholipase C activity IDA 16517693
GO:0007204 positive regulation of cytosolic calcium ion concentration --
genes like me logo Genes that share ontologies with HTR2A: view

Drugs for HTR2A Gene

(79) Drugbank Compounds for HTR2A Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Cisapride
  • (+-)-Cisapride
81098-60-4 Target agonist approved, investigational, withdrawn
Amisulpride
  • 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide
53583-79-2 2159 Target antagonist approved, investigational
Apomorphine
  • (-)-10,11-Dihydroxyaporphine
41372-20-7 6005 Target agonist approved, investigational
Aripiprazole
  • Abilify
129722-12-9 60795 Target antagonist approved, investigational
Bromocriptine
  • (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
25614-03-3 31101 Target agonist approved, investigational

(5) Tocris Compounds for HTR2A Gene

Compound Action Cas Number
Ketanserin tartrate Selective 5-HT2A antagonist. Also antagonist at 5-HT1D [83846-83-7]
MDL 100907 Potent and selective 5-HT2A antagonist [139290-65-6]
Mesulergine hydrochloride 5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist [72786-12-0]
NBOH-2C-CN hydrochloride High affinity, selective 5-HT2A agonist [1539266-32-4]
TCB-2 Potent, high affinity 5-HT2A agonist [912342-28-0]

(44) ApexBio Compounds for HTR2A Gene

Compound Action Cas Number
Amitriptyline HCl Serotonin /norepinephrine receptor/5-HT4/5-HT2 inhibitor [549-18-8]
Asenapine Inhibits adrenergic receptor/5-HT receptor [85650-56-2]
Bilobalide Neuroprotective agent [33570-04-6]
Blonanserin Atypical antipsychotic [132810-10-7]
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker [17321-77-6]
Dapoxetine HCl Selective serotonin reuptake inhibitor [129938-20-1]
Desvenlafaxine [93413-62-8]
Desvenlafaxine Succinate [386750-22-7]
Duloxetine HCl [136434-34-9]
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor [219861-08-2]
Fenspiride HCl [5053-8-7]
Fluoxetine HCl Serotonin reuptake inhibitor,selective [56296-78-7]
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant [61718-82-9]
Iloperidone Dopamine (D2) and serotonin (5HT2) receptor antagonist [133454-47-4]
Ketanserin [74050-98-9]
Lorcaserin HCl [846589-98-8]
Loxapine Succinate [27833-64-3]
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor [367514-88-3]
LY310762 [192927-92-7]
Milnacipran HCl [101152-94-7]
Mosapride Citrate 5-HT receptor agonist [112885-42-4]
Naratriptan [143388-64-1]
Olanzapine [132539-06-1]
Ondansetron [99614-02-5]
Palonosetron HCl [135729-62-3]
Penfluridol [26864-56-2]
Pizotifen Malate [5189-11-7]
PRX-08066 Maleic acid 5-HT2B receptor antagonist,potent and selective [866206-55-5]
Risperidone SR-2A inhibitor [106266-06-2]
Rizatriptan Benzoate [145202-66-0]
RS 127445 5-HT2B receptor antagonist,high affinity [199864-87-4]
SB271046 [209481-20-9]
SEA0400 Specific inhibitor of Na+/Ca2+ exchange [223104-29-8]
Sertraline HCl [79559-97-0]
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant [30123-17-2]
Trazodone HCl Antidepressant [25332-39-2]
Tropisetron [105826-92-4]
Urapidil HCl [64887-14-5]
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor [99300-78-4]
Vortioxetine 5-HT receptors antagonist [508233-74-7]
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic [960203-27-4]
VUF 10166 [155584-74-0]
Ziprasidone HCl Serotonin and dopamine receptor antagonist [122883-93-6]
Zolmitriptan [139264-17-8]

(59) HMDB Compounds for HTR2A Gene

Compound Synonyms Cas Number PubMed IDs
5-O-Desmethyldonepezil
Acepromazine
  • 10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone
61-00-7
Amisulpride
  • Aminosultopride
53583-79-2
Apomorphine
  • Apomorfin
41372-20-7
Aripiprazole
  • Abilify
129722-12-9

(112) IUPHAR Ligand for HTR2A Gene

Ligand Type Action Affinity Pubmed IDs
asenapine Antagonist Antagonist 9.8
[3H]ketanserin Antagonist Antagonist 9.7
S33084 Antagonist Antagonist 9.6
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
LY86057 Antagonist Antagonist 9.2
SB 228357 Antagonist Antagonist 9.1
LY53857 Antagonist Antagonist 9.1
[3H](+)DOB Agonist Full agonist 9.1
SB 242084 Antagonist Antagonist 9
SB 243213 Antagonist Antagonist 9
(+)-LSD Agonist Full agonist 9
terguride Antagonist Antagonist 8.9
DOB Agonist Full agonist 8.9
quetiapine Antagonist Antagonist 8.7
SB 221284 Antagonist Antagonist 8.7
roxindole Antagonist Antagonist 8.6
ergotamine Agonist Full agonist 8.6
DOI Agonist Full agonist 8.6
(+)-butaclamol Antagonist Antagonist 8.5
m-CPP Agonist Partial agonist 8.5
AL-37350A Agonist Full agonist 8.5
thiothixene Antagonist Antagonist 8.4
LSD Agonist Full agonist 8.4
S 16924 Agonist Partial agonist 8.4
(R)-DOI Agonist Full agonist 8.4
RS-102221 Antagonist Antagonist 8.4
methylergonovine Agonist Full agonist 8.3
loxapine Antagonist Antagonist 8.2
Ro 60-0175 Agonist Full agonist 8.2
VER-3323 Agonist Full agonist 8.2
perphenazine Antagonist Antagonist 8.1
pindolol Antagonist Antagonist 8.1
lorcaserin Agonist Full agonist 8.1
(+)-DOI Agonist Full agonist 8.1
org 37684 Agonist Full agonist 8.1
SDZ SER-082 Antagonist Antagonist 8.1
bufotenine Antagonist Antagonist 8
amesergide Antagonist Antagonist 8
fluspirilene Antagonist Antagonist 7.9
SB 206553 Antagonist Antagonist 7.9
LY215840 Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
risperidone Antagonist Antagonist 7.8
org 12962 Agonist Full agonist 7.8
fluphenazine Antagonist Antagonist 7.7
thioridazine Antagonist Antagonist 7.7
quinpirole Agonist Full agonist 7.7
SB 215505 Antagonist Antagonist 7.7
MDL-100,907 Antagonist Antagonist 7.7
EGIS-7625 Antagonist Antagonist 7.7
sergolexole Antagonist Antagonist 7.7
9-OH-risperidone Antagonist Antagonist 7.5
aripiprazole Antagonist Antagonist 7.5
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
sarpogrelate Antagonist Antagonist 7.4
mianserin Antagonist Antagonist 7.3
quipazine Agonist Full agonist 7.3
trifluoperazine Antagonist Antagonist 7.2
lisuride Agonist Partial agonist 7.2
tryptamine Agonist Full agonist 7.2
LY314228 Antagonist Antagonist 7.2
BW723C86 Agonist Full agonist 7.1
MK-212 Agonist Full agonist 7
LY320954 Antagonist Antagonist 7
sertindole Antagonist Antagonist 6.9
LY063518 Antagonist Antagonist 6.9
5-MeOT Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
clozapine Antagonist Antagonist 6.7
spiperone Antagonist Antagonist 6.7
cabergoline Agonist Full agonist 6.7
MDL-11,939 Antagonist Antagonist 6.6
trazodone Antagonist Antagonist 6.6
N-1-isopropyltryptamine Agonist Full agonist 6.6
pergolide Agonist Full agonist 6.5
duloxetine Antagonist Antagonist 6.4
TFMPP Agonist Full agonist 6.4
ketanserin Inhibitor Inhibition 6.3
LY344864 Agonist Full agonist 6.3
cyamemazine Antagonist Antagonist 6.3
SB 216641 Agonist Partial agonist 6.3
RS-127445 Antagonist Antagonist 6.3
N-1-isopropyl-5-MeOT Agonist Full agonist 6.3
pimozide Antagonist Antagonist 6.2
bromocriptine Agonist Partial agonist 6.2
RU 24969 Agonist Full agonist 6.2
agomelatine Antagonist Antagonist 6.2
L-741,626 Antagonist Antagonist 6.2
haloperidol Antagonist Antagonist 6.1
5-CT Agonist Full agonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
alpha-methyl-5-HT Agonist Full agonist 5.8
GR-127935 Agonist Partial agonist 5.8
AMI-193 Antagonist Antagonist 5.8
molindone Antagonist Antagonist 5.7
mesulergine Antagonist Antagonist 5.7
SB 224289 Antagonist Antagonist 5.7
pipamperone Antagonist Antagonist 5.6
donitriptan Agonist Partial agonist 5.6
CGS-12066 Agonist Full agonist 5.6
AC-90179 Antagonist Inverse agonist 5.5
apomorphine Activator Activation 5.1
5-HT Inhibitor Inhibition 2.2
chlorpromazine Channel blocker None
[18F]altanserin Antagonist Antagonist
[11C]MDL100907 None None

(119) Novoseek inferred chemical compound relationships for HTR2A Gene

Compound -log(P) Hits PubMed IDs
ketanserin 93.4 108
5-hydroxytryptamine 89.4 134
ritanserin 86.3 48
1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 84.1 17
methiothepin 83.7 12

(18) PharmGKB related drug/compound annotations for HTR2A Gene

Drug/compound Annotation
Analgesics DrugLabel,Clinical Annotation
antidepressants DrugLabel,Clinical Annotation
Antiinflammatory agents, non-steroids DrugLabel,Clinical Annotation
antipsychotics DrugLabel,Clinical Annotation
aripiprazole DrugLabel,Clinical Annotation
citalopram DrugLabel,Clinical Annotation
clozapine DrugLabel,Clinical Annotation
efavirenz DrugLabel,Clinical Annotation
Ergot alkaloids DrugLabel,Clinical Annotation
escitalopram DrugLabel,Clinical Annotation
fluvoxamine DrugLabel,Clinical Annotation
olanzapine DrugLabel,Clinical Annotation
opioids DrugLabel,Clinical Annotation
paroxetine DrugLabel,Clinical Annotation
risperidone DrugLabel,Clinical Annotation
Selective serotonin reuptake inhibitors DrugLabel,Clinical Annotation
sumatriptan DrugLabel,Clinical Annotation
venlafaxine DrugLabel,Clinical Annotation
genes like me logo Genes that share compounds with HTR2A: view

Compound Products

Transcripts for HTR2A Gene

mRNA/cDNA for HTR2A Gene

Unigene Clusters for HTR2A Gene

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR2A Gene

No ASD Table

Relevant External Links for HTR2A Gene

GeneLoc Exon Structure for
HTR2A
ECgene alternative splicing isoforms for
HTR2A

Expression for HTR2A Gene

mRNA expression in normal human tissues for HTR2A Gene

mRNA differential expression in normal tissues according to GTEx for HTR2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (11.3), Brain - Anterior cingulate cortex (BA24) (8.5), and Brain - Cortex (7.6).

Protein differential expression in normal tissues for HTR2A Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR2A Gene

SOURCE GeneReport for Unigene cluster for HTR2A Gene Hs.72630

mRNA Expression by UniProt/SwissProt for HTR2A Gene

P28223-5HT2A_HUMAN
Tissue specificity: Detected in brain cortex (at protein level). Detected in blood platelets.
genes like me logo Genes that share expressions with HTR2A: view

Expression partners for HTR2A Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for HTR2A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR2A 35
  • 90.35 (n)
  • 94.47 (a)
HTR2A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR2A 35
  • 89.22 (n)
  • 93.83 (a)
mouse
(Mus musculus)
Mammalia Htr2a 35
  • 87.54 (n)
  • 91.51 (a)
Htr2a 16
Htr2a 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR2A 35
  • 99.29 (n)
  • 99.79 (a)
HTR2A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr2a 35
  • 87.47 (n)
  • 91.3 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR2A 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR2A 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR2A 35
  • 75.23 (n)
  • 77.73 (a)
HTR2A 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR2A 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr2a 35
  • 70.6 (n)
  • 75.5 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-276l13.4 35
  • 67.12 (n)
  • 70.41 (a)
htr2a 36
  • 66 (a)
OneToMany
HTR2A (2 of 2) 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT2 37
  • 42 (a)
5-HT2 36
  • 16 (a)
ManyToMany
CG42796 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ser-1 35
  • 48.73 (n)
  • 36.7 (a)
ser-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for HTR2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR2A Gene

ENSEMBL:
Gene Tree for HTR2A (if available)
TreeFam:
Gene Tree for HTR2A (if available)

Paralogs for HTR2A Gene

Paralogs for HTR2A Gene

genes like me logo Genes that share paralogs with HTR2A: view

Variants for HTR2A Gene

Sequence variations from dbSNP and Humsavar for HTR2A Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs3125 -- 46,834,716(-) TATCT(C/G)TATGC utr-variant-3-prime
rs2760342 -- 46,864,011(+) TGGAA(A/T)CAACA intron-variant
rs2760341 -- 46,864,000(+) TAGCA(A/G)AGACA intron-variant
rs2760340 -- 46,863,657(+) AAAAA(A/G)AAAAA intron-variant
rs2760339 -- 46,863,517(+) actta(A/G)ggggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR2A Gene

Variant ID Type Subtype PubMed ID
nsv1027 CNV Insertion 18451855
nsv900063 CNV Loss 21882294
nsv510334 CNV Loss 20534489

Relevant External Links for HTR2A Gene

HapMap Linkage Disequilibrium report
HTR2A
Human Gene Mutation Database (HGMD)
HTR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR2A Gene

Disorders for HTR2A Gene

(5) OMIM Diseases for HTR2A Gene (182135)

(88) Novoseek inferred disease relationships for HTR2A Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 76.8 131
major depression 64.3 26
mood disorders 57.3 27
psychotic 56.2 12
obsessive-compulsive disorder 53.5 14

Relevant External Links for HTR2A

Genetic Association Database (GAD)
HTR2A
Human Genome Epidemiology (HuGE) Navigator
HTR2A
genes like me logo Genes that share disorders with HTR2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR2A Gene

Publications for HTR2A Gene

  1. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. (PMID: 18703043) Cussac D. … Rauly-Lestienne I. (Eur. J. Pharmacol. 2008) 3 4 25 26
  2. Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. (PMID: 1330647) Stam N.J. … Olijve W. (Eur. J. Pharmacol. 1992) 3 4 23
  3. Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes. (PMID: 1722404) Saltzman A.G. … Felder S. (Biochem. Biophys. Res. Commun. 1991) 3 4 23
  4. Association between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizophrenia. (PMID: 11317227) Segman R.H. … Lerer B. (Mol. Psychiatry 2001) 3 23 48
  5. Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension. (PMID: 11378836) Liolitsa D. … Lovestone S. (J Hum Hypertens 2001) 3 23 48

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