HTR2A Gene
protein-coding GIFtS: 64
GCID: GC13M047407
|
|
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled(Previous name: 5-hydroxytryptamine (serotonin) receptor 2A )
(Previous symbol: HTR2)
| |
Aliases
for HTR2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled1 2 | | 5-HT2 Receptor2 | | HTR21 2 3 | | 5-Hydroxytryptamine Receptor 2A2 | | 5-HT2A1 2 | | Serotonin 5-HT-2A Receptor2 | | 5-HT-2A2 3 | | 5-HT-23 | | 5-Hydroxytryptamine (Serotonin) Receptor 2A1 | | Serotonin Receptor 2A3 |
Export aliases for HTR2A gene to outside databasesPrevious GC identifers: GC13M045407 GC13M041394 GC13M046344 GC13M045205 GC13M046305 GC13M028201 |
Summaries
for HTR2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HTR2A:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene areassociated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated withresponse to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also havea mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressantdownregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in trachealsmooth muscle contraction, bronchoconstriction, and control of aldosterone production
 summary
for HTR2A: Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocotex,
caudate nucleus, nucleus accumbens, olfactory tubercle, hippocampus and vascular and non-vascular smooth
muscle cells. 5-HT2A receptors play a role in appetite control, thermoregulation and sleep. 5-HT2A receptors
are also involved, along with various other 5-HT receptor populations, in cardiovascular function and muscle
contraction. The human 5-HT2A receptor gene has been localized to chromosome 13 (13q14-q21).
Gene Wiki entry for HTR2A (5-HT2A receptor)
|
Genomic Views
for HTR2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HTR2A gene promoter:
Pbx1a Brachyury MIF-1 Nkx2-5 S8 POU2F1 Nkx6-1 POU2F1a c-Myb STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for HTR2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14-q21 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14-q21HTR2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M047407: view genomic region
(about GC identifiers)
Start:
|
47,407,513 bp from pter |
End:
|
47,471,169 bp from pter |
Size:
|
63,657 bases |
Orientation:
|
minus strand |
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Proteins
for HTR2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223 (See
protein sequence)Recommended Name: 5-hydroxytryptamine receptor 2A Size: 471 amino acids; 52603 Da
Subunit: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the postsynapticthickening of axo-dendritic synapses (By similarity)
Secondary accessions: B2RAC5 B4DZ79 F5GWE8 Q5T8C0Alternative splicing: 2 isoforms: P28223-1 P28223-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HTR2A: NX_P28223
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P28223
HTR2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000612.1 NP_001159419.1
ENSEMBL proteins: ENSP00000367959 ENSP00000441861 ENSP00000437737 Reactome Protein details: P28223
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
HTR2A for ontologies About GeneDecksing
HTR2A Antibody Products:
Assay Products for HTR2A: |
Protein
Domains /
Families
for HTR2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HTR2A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P28223ProtoNet protein and cluster: P28223 2 Blocks protein families: IPB000455 5-hydroxytryptamine 2A receptor signature IPB002231 5-hydroxytryptamine receptor signature
UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223Domain: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for HTR2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone thatfunctions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with Gproteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in trachealsmooth muscle contraction, bronchoconstriction, and control of aldosterone production Genatlas biochemistry entry for HTR2A:5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating thephosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated withschizophrenia
Clone
Products: |  | EMD Millipore Clones for the Expression of HTR2A | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for HTR2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2A |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
HTR2A for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for HTR2A: Htr2atm1Rhn Htr2atm2Grch Htr2atm1Grch
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Htr2a):
HTR2A for phenotypes About GeneDecksing
|
Pathways & Interactions
for HTR2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Monoamine GPCRs | | | 3 | Signaling by GPCR | | | 4 | G alpha (q) signalling events | | | 5 | Signaling in Gap Junctions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HTR2A
5  BioSystems Pathways for HTR2A
5/9 
Reactome Pathways for HTR2A (see all 9)
1  PharmGKB Pathway for HTR2A
3 
Kegg Pathways (Kegg details for HTR2A):
HTR2A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/144 Interacting proteins for HTR2A (P282232, 3 ENSP000003679594) via UniProtKB, MINT, STRING, and/or I2D (see all 144)About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table
HTR2A for ontologies About GeneDecksing
|
Drugs & Compounds
for HTR2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HTR2A for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for HTR2A |
Compounds for HTR2A available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Ketanserin tartrate | Selective 5-HT2A antagonist. Also antagonist at 5-HT1D | [83846-83-7] | | DOI hydrochloride | Mixed 5-HT2A/2C agonist | [42203-78-1] | | TCB-2 | Potent, high affinity 5-HT2A agonist | -- | | LY 215840 | 5-HT2/5-HT7 antagonist | [137328-52-0] | | Fananserin | 5-HT2A antagonist. Also D4 antagonist | [127625-29-0] |
8 HMDB Compounds for HTR2A About this table
10/64 DrugBank Compounds for HTR2A (see all 64) About this table
10/119 Novoseek chemical compound relationships for HTR2A gene (see all 119) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ketanserin |
93.4 |
154 |
1479590 (4), 19879056 (2), 8388988 (2), 7707322 (2) (see all 99) |
| 5-hydroxytryptamine |
89.4 |
339 |
1355262 (7), 18430065 (5), 1560366 (3), 9384503 (3) (see all 99) |
| ritanserin |
86.3 |
50 |
15787439 (2), 7902766 (2), 2117764 (2), 1536032 (2) (see all 42) |
| 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane |
84.1 |
18 |
1769371 (1), 7813581 (1), 7760026 (1), 8825354 (1) (see all 17) |
| methiothepin |
83.7 |
13 |
10374714 (1), 1425972 (1), 1393286 (1), 2086249 (1) (see all 12) |
| mesulergine |
82.1 |
7 |
11230991 (1), 1644189 (1), 1525017 (1), 1435740 (1) (see all 7) |
| setoperone |
81.8 |
4 |
10401447 (1), 7687976 (1), 10435604 (1) |
| 5-carboxamidotryptamine |
81.4 |
9 |
8825354 (1), 9522163 (1), 8786274 (1), 1849768 (1) (see all 7) |
| spiperone |
79.3 |
25 |
11078195 (1), 2164094 (1), 8577395 (1), 2068047 (1) (see all 21) |
| clozapine |
78.7 |
99 |
20521326 (4), 19142110 (4), 9989565 (3), 7573582 (3) (see all 56) |
6 PharmGKB related drug/compound annotations for HTR2A geneAbout this table
Search CenterWatch for drugs/clinical trials and news about HTR2A / 5HT2A
|
Transcripts
for HTR2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HTR2A gene (2 alternative transcripts): NM_000621.4 NM_001165947.2 Unigene Cluster for HTR2A: 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Hs.72630 [show with all ESTs]Unigene Representative Sequence: NM_0006213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378688 ENST00000543956(uc001vbr.3) ENST00000542664(uc010acr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTR2A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HTR2A (NM_000621) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTR2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR2A |
Additional cDNA sequence: AF498982.1 AK302787.1 AK314132.1 BC069356.1 BC069576.1 BC074848.2 BC074849.2 BC096839.1 BX647777.1 M86841.1 S71229.1 X57830.1 4 DOTS entries: DT.456099 DT.209624 DT.305223 DT.95108653 22 AceView cDNA sequences: S71229 BC069576 AI379882 BC074848 AF498982 BX108650 BC074849 BC069356 AA954285 X57830 AW117542 AI565418 M86841 NM_000621 BX647777 CB565885 CA393776 BG703062 AI005152 CD105069 AA166934 AA166746
GeneLoc Exon Structure
|
Expression
for HTR2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTR2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HTR2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR2A
SOURCE GeneReport for Unigene cluster: Hs.72630
SABiosciences Expression via Pathway-Focused PCR Arrays including HTR2A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTR2A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTR2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR2A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2A |
Orthologs
for HTR2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HTR2A gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HTR2A1 |
5-hydroxytryptamine (serotonin) receptor 2A |
75.23(n)
77.73(a) |
|
428070 XM_425628.3 XP_425628.2 |
lizard
(Anolis carolinensis) |
Reptilia |
HTR2A6 |
-- |
70(a) |
1 ↔ 1 |
1(137032501-137053331) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5598061 |
5-hydroxytryptamine receptor 2A-like |
67.12(n)
70.41(a) |
|
559806 XM_683178.2 XP_688270.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
5-HT23 |
serotonin receptor signaling pathway
G-protein more |
42(a) |
|
3 82C5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
ser-16dop-56 |
Protein DOP-5 |
17(a)11(a) |
1 ↔ manypossible ortholog |
X(16579672-16587389) V(11362438-11366203) |
ENSEMBL Gene Tree for HTR2A (if available)
TreeFam Gene Tree for HTR2A (if available) |
Paralogs
for HTR2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HTR2A gene
- TAAR62 HTR62 TAAR22 ADRB12 TAAR82 HRH22 HTR2B2 DRD12
- HTR2C2 TAAR12 ADRB22 HTR42 DRD52 ADRB32 TAAR52
18/24 SIMAP similar genes for HTR2A using alignment to 6 protein entries: 5HT2A_HUMAN (see all proteins)
(see all similar genes):GHSR HTR2B HTR2C ADRA1A ADRA2C CCKBR
CHRM2 DRD3 HTR5A CHRM1 HTR1B HTR1D
HTR1F HTR6 HTR7 ADRA1B HTR1E SSTR5
HTR2A for paralogs About GeneDecksing
|
Genomic Variants
for HTR2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HTR2A (47407513 - 47471169 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HTR2A: --
Human Gene Mutation Database (HGMD): HTR2A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR2A |
|
Disorders
/ Diseases
for HTR2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTR2A for disorders About GeneDecksing
OMIM gene information: 182135
OMIM disorders: 181500 164230 608516 103780 606788
20/133  diseases for HTR2A (see all 133): About MalaCardsobsessive-compulsive disorder major depressive disorder major depressive disorder, response to citalopram therapy in seasonal affective disorder
sudden infant death syndrome attention deficit hyperactivity disorder antisocial personality disorder spinal cord injury
schizophrenia generalized anxiety disorder intermittent claudication anorexia nervosa
progressive multifocal leukoencephalopathy anxiety disorder personality disorder lewy body dementia
bulimia nervosa borderline personality disorder thromboangiitis obliterans schizoaffective disorder
7 diseases from the University of Copenhagen DISEASES database for HTR2A:Schizophrenia Attention deficit hyperactivity disorder Alcohol dependence Cyclothymic disorder
Tic disorder Schizoaffective disorder Antisocial personality disorder 10/88 Novoseek disease relationships for HTR2A gene (see all 88) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| schizophrenia |
76.8 |
166 |
19855357 (5), 14744462 (3), 17069769 (3), 16405867 (3) (see all 99) |
| major depression |
64.3 |
29 |
11311507 (3), 2310804 (2), 19428704 (2), 7865496 (2) (see all 21) |
| mood disorders |
57.3 |
35 |
10758249 (3), 11992560 (3), 17884017 (3), 19428704 (2) (see all 20) |
| psychotic |
56.2 |
18 |
10686558 (2), 18712714 (1), 10087520 (1), 10192823 (1) (see all 11) |
| obsessive-compulsive disorder |
53.5 |
19 |
11239910 (3), 18339223 (2), 1624756 (1), 12476319 (1) (see all 11) |
| bipolar disorder |
50.7 |
25 |
9341875 (4), 19584773 (4), 12622403 (2), 11093065 (2) (see all 14) |
| catalepsy |
49.8 |
3 |
10188965 (1), 8935798 (1) |
| schizoaffective disorder |
47.7 |
4 |
20521326 (1), 19142110 (1), 15121646 (1), 17500207 (1) |
| migraine |
45.3 |
25 |
8675433 (5), 2045831 (4), 1871321 (1), 1337765 (1) (see all 14) |
| psychiatric disorder |
44.9 |
12 |
17691947 (3), 7911139 (1), 7542676 (1), 19004992 (1) (see all 8) |
Genetic Association Database (GAD): HTR2A
Human Genome Epidemiology (HuGE) Navigator: HTR2A (387 documents)
Export disorders for HTR2A gene to outside databases
|
Publications
for HTR2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HTR2A gene, integrated from 9 sources (see all 1617):
(articles sorted by number of sources associating them with HTR2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. (PubMed id 15037867)1, 4, 7 Reist C....Goldman D. (2004)
- Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. (PubMed id 8655141)1, 2, 4 Erdmann J....Noethen M.M. (1996)
- Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. (PubMed id 8035173)1, 2, 3 Cook E.H. Jr....Leventhal B.L. (1994)
- 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. (PubMed id 15048642)1, 4, 9 Zhang X.N....Zhang L.N. (2004)
- Association analysis of the catechol-o-methyltransferase (COMT), serotonin transporter (5-HTT) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive-compulsive disorder. (PubMed id 15005715)1, 4, 9 Meira-Lima I....Vallada H. (2004)
- The serotonin-2A receptor polymorphism and smoking behavior in Japan. (PubMed id 15564892)1, 4, 9 Terayama H....Iwahashi K. (2004)
- Lack of association between serotonin-2A receptor gene (HTR2A) polymorphisms and tardive dyskinesia in schizophrenia. (PubMed id 11317228)1, 4, 9 Basile V.S....Kennedy J.L. (2001)
- [Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome] (PubMed id 11172633)1, 4, 9 Huang Y....Collier D.A. (2001)
- Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes. (PubMed id 1330647)1, 2, 9 Stam N.J.... Olijve W. (1992)
- Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. (PubMed id 11920858)1, 4, 9 Li T....Collier D.A. (2002)
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External Searches for HTR2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HTR2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HTR2A gene
(According to HUGE)
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Specialized Databases showing HTR2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HTR2A | Pharmacogenomics, SNPs, Pathways | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HTR2A |
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| Patent Information for HTR2A gene:
Search GeneIP for patents involving HTR2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HTR2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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