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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR2A Gene

protein-coding   GIFtS: 68
GCID: GC13M047407

5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 2A)
(Previous symbol: HTR2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled1 2     5-HT2 Receptor2
HTR21 2 3     5-Hydroxytryptamine Receptor 2A2
5-HT-2A2 3     Serotonin 5-HT-2A Receptor2
5-Hydroxytryptamine (Serotonin) Receptor 2A1     5-HT-23
5-HT2A2     Serotonin Receptor 2A3

External Ids:    HGNC: 52931   Entrez Gene: 33562   Ensembl: ENSG000001024687   OMIM: 1821355   UniProtKB: P282233   

Export aliases for HTR2A gene to outside databases

Previous GC identifers: GC13M045407 GC13M041394 GC13M046344 GC13M045205 GC13M046305 GC13M028201


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR2A Gene:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene
are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated
with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who
also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this
antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for HTR2A Gene: 
HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR2A include major depressive disorder, and seasonal affective disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include protein complex binding and phosphatidylinositol phospholipase C activity. An important paralog of this gene is DRD4.

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association
with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved
in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

summary for HTR2A Gene:
Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex,
caudate nucleus, nucleus accumbens, olfactory tubercle, hippocampus and vascular and non-vascular smooth
muscle cells. 5-HT2A receptors play a role in appetite control, thermoregulation and sleep. 5-HT2A receptors
are also involved, along with various other 5-HT receptor populations, in cardiovascular function and muscle
contraction. The human 5-HT2A receptor gene has been localized to chromosome 13 (13q14-q21).

Gene Wiki entry for HTR2A (5-HT2A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR2A gene promoter:
         Pbx1a   Brachyury   MIF-1   Nkx2-5   S8   POU2F1   Nkx6-1   POU2F1a   c-Myb   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR2A promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14-q21   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14-q21

HTR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR2A gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M047407:  view genomic region     (about GC identifiers)

Start:
47,405,685 bp from pter      End:
47,471,169 bp from pter
Size:
65,485 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 2A  
Size: 471 amino acids; 52603 Da
Subunit: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localizes to the
postsynaptic thickening of axo-dendritic synapses (By similarity)
Secondary accessions: B2RAC5 B4DZ79 F5GWE8 Q5T8C0
Alternative splicing: 2 isoforms:  P28223-1   P28223-2   (Ref.5 (BAG63991) sequence is in conflict in position: 49:D->N)

Explore the universe of human proteins at neXtProt for HTR2A: NX_P28223

Explore proteomics data for HTR2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28223

  • HTR2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTR2A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000612.1  NP_001159419.1  

    ENSEMBL proteins: 
     ENSP00000367959   ENSP00000441861   ENSP00000437737  
    Reactome Protein details: P28223
    Human Recombinant Protein Products for HTR2A: 
    EMD Millipore Purified and/or Recombinant HTR2A Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR2A 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0005901caveola IEA--

    HTR2A for ontologies           About GeneDecksing



    HTR2A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT2A receptor 
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000455 5HT2A_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28223

    ProtoNet protein and cluster: P28223

    2 Blocks protein domains:
    IPB000455 5-hydroxytryptamine 2A receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT2A_HUMAN, P28223
    Domain: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT2A_HUMAN, P28223
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association
    with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved
    in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production

         Genatlas biochemistry entry for HTR2A:
    5-hydroxytryptamine (serotonin) receptor,subtype 2A,G protein coupled receptor superfamily,activating the
    phosphatidylinositol cycle,paternally imprinted in some individuals (polymorphic imprinting),not associated with
    schizophrenia

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IEA--
    GO:0004435phosphatidylinositol phospholipase C activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA15862800
    GO:0008144drug binding IDA15831837
         
    HTR2A for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Htr2a):
     behavior/neurological  digestive/alimentary  endocrine/exocrine gland  muscle  skeleton 

    HTR2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR2A: Htr2atm1Rhn Htr2atm2Grch Htr2atm1Grch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HTR2A 
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    SwitchGear 3'UTR luciferase reporter plasmidHTR2A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): HTR2A (NM_000621)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR2A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HTR2A About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.36
    Amine ligand-binding receptors0.79
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics0.33
    3Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    5G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HTR2A
        Intracellular Calcium Signaling
    Signaling in Gap Junctions

    5 BioSystems Pathways for HTR2A
        Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
    SIDS Susceptibility Pathways
    GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/9        Reactome Pathways for HTR2A (see all 9)
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)

    1 PharmGKB Pathway for HTR2A
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    4         Kegg Pathways  (Kegg details for HTR2A):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gap junction
    Serotonergic synapse


    HTR2A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/145 Interacting proteins for HTR2A (P282232, 3 ENSP000003679594) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-73187 I2D: score=1 STRING: ENSP00000370410
    GNAQP501483, ENSP000002865484I2D: score=2 STRING: ENSP00000286548
    ANKS1BQ7Z6G83, ENSP000003313814I2D: score=1 STRING: ENSP00000331381
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    GLULP151043, ENSP000003079004I2D: score=1 STRING: ENSP00000307900
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0006661phosphatidylinositol biosynthetic process ----
    GO:0006874cellular calcium ion homeostasis IDA16517693
    GO:0006939smooth muscle contraction IEA--
    GO:0006950response to stress IEA--

    HTR2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for HTR2A

    Compounds for HTR2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Risperidone5-HT2A antagonist[106266-06-2]
    Mesulergine hydrochloride5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist[64795-35-3]
    Ketanserin tartrateSelective 5-HT2A antagonist. Also antagonist at 5-HT1D[83846-83-7]
    TCB-2 Potent, high affinity 5-HT2A agonist [912342-28-0]
    AT 1015Long-acting 5-HT2A antagonist[190508-50-0]

    8 HMDB Compounds for HTR2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    CalciumCa (see all 2)7440-70-2--
    DonepezilAricept (see all 3)120014-06-4--
    OlanzapineLanzac (see all 5)132539-06-1--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    RisperidoneBelivon (see all 7)106266-06-2--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    VenlafaxineEfectin (see all 6)93413-69-5--

    10/66 DrugBank Compounds for HTR2A (see all 66)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Olanzapine-- 132539-06-1targetantagonist10227113 15358979 16905159 15816787 17848919 11752352 17316700 14530903 16038601
    NefazodoneNefazodona [Spanish] (see all 4)83366-66-9targetantagonist10435395 7855217 9098663 10220119 14520130 7649970 10577608 12873632
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 15121646 12530423 12445705 17450180 17848919 11509214
    Clozapine-- 5786-21-0targetantagonist14687870 14751426 12973385 7520908 14530903 15037867
    MirtazapineMepirzepine (see all 5)61337-67-5targetantagonist10446735 10446738 11607047 11063897 10451911 10446734
    Paliperidone-- 144598-75-4targetantagonist12211096 7542676 7520908 7531353 7524043 11132243
    TrazodoneTrazodona [INN-Spanish] (see all 4)19794-93-5targetantagonist11714900 15610924 7855217 3039120 10594316 1365657
    Clomipramine3-Chloroimipramine (see all 6)303-49-1targetantagonist14501155 9862411 1296670 8558452 10682715
    Cyproheptadine-- 129-03-3targetantagonist12233819 1403790 1358088 16418149 12498911
    MMDA(+-)-mmda (see all 7)13674-05-0targetagonist17209801 9666084 10987842 17139284 17016423

    10/112 IUPHAR Ligands for HTR2A (5-HT2A receptor) (see all 112)    About this table 
    LigandTypeActionAffinityPubmed IDs
    risperidone
    AntagonistInverse agonist9.3 - 108935801 12629531 12176106
    AC-90179
    AntagonistInverse agonist9.715102927
    [3H]ketanserin
    AntagonistAntagonist8.6 - 9.715322733 12738034
    ketanserin
    AntagonistAntagonist8.1 - 9.715322733 8845011 12738034
    mianserin
    AntagonistAntagonist7.7 - 9.615322733 15107597 10611634
    asenapine
    AgonistFull agonist9.68935801
    ziprasidone
    AntagonistAntagonist8.8 - 9.58935801 12629531 12176106
    spiperone
    AntagonistAntagonist7.8 - 9.415322733 2233697 8534270
    LSD
    AgonistFull agonist9.48663249
    methylergonovine
    AgonistFull agonist9.415322733

    10/119 Novoseek inferred chemical compound relationships for HTR2A gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ketanserin 93.4 154 1479590 (4), 19879056 (2), 8388988 (2), 7707322 (2) (see all 99)
    5-hydroxytryptamine 89.4 339 1355262 (7), 18430065 (5), 1560366 (3), 9384503 (3) (see all 99)
    ritanserin 86.3 50 15787439 (2), 7902766 (2), 2117764 (2), 1536032 (2) (see all 42)
    1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane 84.1 18 1769371 (1), 7813581 (1), 7760026 (1), 8825354 (1) (see all 17)
    methiothepin 83.7 13 10374714 (1), 1425972 (1), 1393286 (1), 2086249 (1) (see all 12)
    mesulergine 82.1 7 11230991 (1), 1644189 (1), 1525017 (1), 1435740 (1) (see all 7)
    setoperone 81.8 4 10401447 (1), 7687976 (1), 10435604 (1)
    5-carboxamidotryptamine 81.4 9 8825354 (1), 9522163 (1), 8786274 (1), 1849768 (1) (see all 7)
    spiperone 79.3 25 11078195 (1), 2164094 (1), 8577395 (1), 2068047 (1) (see all 21)
    clozapine 78.7 99 20521326 (4), 19142110 (4), 9989565 (3), 7573582 (3) (see all 56)

    7 PharmGKB related drug/compound annotations for HTR2A gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    citalopramCA  
    escitalopramCA  
    olanzapineCA  
    risperidoneCA  
    venlafaxineCA  

    Search CenterWatch for drugs/clinical trials and news about HTR2A / 5HT2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTR2A gene (2 alternative transcripts): 
    NM_000621.4  NM_001165947.2  

    Unigene Cluster for HTR2A:

    5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
    Hs.72630  [show with all ESTs]
    Unigene Representative Sequence: NM_000621
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378688 ENST00000543956(uc001vbr.3) ENST00000542664(uc010acr.3)


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    Additional mRNA sequence: 

    AF498982.1 AK302787.1 AK314132.1 BC069356.1 BC069576.1 BC074848.2 BC074849.2 BC096839.1 
    BX647777.1 M86841.1 S71229.1 X57830.1 

    4 DOTS entries:

    DT.456099  DT.209624  DT.305223  DT.95108653 

    22 AceView cDNA sequences:

    BC069356 BC074848 BC069576 BC074849 BX108650 AI379882 AF498982 S71229 
    BX647777 CB565885 AW117542 AA954285 AI565418 NM_000621 X57830 M86841 
    CA393776 BG703062 AI005152 CD105069 AA166934 AA166746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR2A expression in normal human tissues (normalized intensities)      HTR2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR2A Expression
    About this image


    HTR2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See HTR2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR2A

    SOURCE GeneReport for Unigene cluster: Hs.72630
        SABiosciences Expression via Pathway-Focused PCR Arrays including HTR2A: 
              Parkinson's Disease in human mouse rat
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HTR2A gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr2a1 , 5 5-hydroxytryptamine (serotonin) receptor 2A1, 5 87.54(n)1
    91.51(a)1
      14 (39.37 cM)5
    155581  NM_172812.21  NP_766400.11 
     746408405 
    chicken
    (Gallus gallus)
    Aves HTR2A1 5-hydroxytryptamine (serotonin) receptor 2A 75.23(n)
    77.73(a)
      428070  XM_425628.3  XP_425628.2 
    lizard
    (Anolis carolinensis)
    Reptilia HTR2A6
    Uncharacterized protein
    70(a)
    1 ↔ 1
    1(137032501-137053331)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5598061 5-hydroxytryptamine receptor 2A-like 67.12(n)
    70.41(a)
      559806  XM_683178.2  XP_688270.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT23 serotonin receptor signaling pathway
    G-protein more
    42(a)   3 82C5   --


    ENSEMBL Gene Tree for HTR2A (if available)
    TreeFam Gene Tree for HTR2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR2A gene
    DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  HTR2C2  
    ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18/23 SIMAP similar genes for HTR2A using alignment to 6 protein entries:     5HT2A_HUMAN (see all proteins) (see all similar genes):
    HTR2B    GHSR    HTR2C    ADRA1A    ADRA2C    CCKBR
    CHRM2    DRD3    HTR5A    CHRM1    HTR1B    HTR1D
    HTR1F    HTR6    HTR7    ADRA1B    HTR1E    SSTR5

    HTR2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1430 SNPs in HTR2A are shown (see all 1430)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394728491,2
    Cuntested128352860(+) AGGGCC/G/TCCAAT 4 G syn10--------
    rs745958071,2
    C--28247715(+) AAAAAA/CAAAAA 2 -- int10--------
    rs1501531041,2
    --28349082(+) GGATCA/CTAGCT 2 -- ds50010--------
    rs1123220001,2
    C,F--28349129(+) TTGCTC/GTCGAA 2 -- ds50012Minor allele frequency- G:0.07CSA WA 120
    rs1850794201,2
    --28349151(+) TACCTA/GGAGTT 2 -- ds50010--------
    rs1159554271,2
    C,F--28349160(+) TTCTGA/CGTCTG 2 -- ds50010--------
    rs1403735541,2
    --28349192(+) AATTCC/TGTTTA 2 -- ds50010--------
    rs766650581,2
    C,F--28349210(+) CAGCTA/GTGGAC 2 -- ds50011Minor allele frequency- G:0.06WA 118
    rs1455790641,2
    C--28349271(+) CCTTTC/GTTGAA 2 -- ut310--------
    rs619483071,2
    C--28349285(+) TTTTAG/ACATCG 2 -- ut312Minor allele frequency- A:0.07NA 122

    HapMap Linkage Disequilibrium report for HTR2A (47405685 - 47471169 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HTR2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1027CNV Insertion18451855
    nsv900063CNV Loss21882294
    nsv510334CNV Loss20534489


    Human Gene Mutation Database (HGMD): HTR2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182135   
    OMIM disorders: 181500  164230  608516  103780  606788  
    20/119 diseases for HTR2A (see all 119):    About MalaCards
    major depressive disorder    seasonal affective disorder    dysthymic disorder    akinetopsia
    major depressive disorder, response to citalopram therapy in    obsessive-compulsive disorder    anorexia nervosa    schizoaffective disorder
    tic disorder    intermittent claudication    chronic cervicitis    thromboangiitis obliterans
    alcoholic psychosis    alcohol dependence    sleep apnea    fibromyalgia
    heart valve disease    serotonin syndrome    tourette disorder    psychotic disorder

    6 diseases from the University of Copenhagen DISEASES database for HTR2A:
    Schizophrenia     Attention deficit hyperactivity disorder     Alcohol dependence     Cyclothymic disorder
    Schizoaffective disorder     Antisocial personality disorder

    HTR2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/88 Novoseek inferred disease relationships for HTR2A gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 76.8 166 19855357 (5), 14744462 (3), 17069769 (3), 16405867 (3) (see all 99)
    major depression 64.3 29 11311507 (3), 2310804 (2), 19428704 (2), 7865496 (2) (see all 21)
    mood disorders 57.3 35 10758249 (3), 11992560 (3), 17884017 (3), 19428704 (2) (see all 20)
    psychotic 56.2 18 10686558 (2), 18712714 (1), 10087520 (1), 10192823 (1) (see all 11)
    obsessive-compulsive disorder 53.5 19 11239910 (3), 18339223 (2), 1624756 (1), 12476319 (1) (see all 11)
    bipolar disorder 50.7 25 9341875 (4), 19584773 (4), 12622403 (2), 11093065 (2) (see all 14)
    catalepsy 49.8 3 10188965 (1), 8935798 (1)
    schizoaffective disorder 47.7 4 20521326 (1), 19142110 (1), 15121646 (1), 17500207 (1)
    migraine 45.3 25 8675433 (5), 2045831 (4), 1871321 (1), 1337765 (1) (see all 14)
    psychiatric disorder 44.9 12 17691947 (3), 7911139 (1), 7542676 (1), 19004992 (1) (see all 8)

    Genetic Association Database (GAD): HTR2A
    Human Genome Epidemiology (HuGE) Navigator: HTR2A (387 documents)

    Export disorders for HTR2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR2A gene, integrated from 9 sources (see all 1650):
    (articles sorted by number of sources associating them with HTR2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. (PubMed id 15037867)1, 4, 7 Reist C....Goldman D. (2004)
    2. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. (PubMed id 8655141)1, 2, 4 Erdmann J....Noethen M.M. (1996)
    3. Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor. (PubMed id 8035173)1, 2, 3 Cook E.H. Jr....Leventhal B.L. (1994)
    4. Analysis of serotonin receptor 2A gene (HTR2A): assoc iation study with autism spectrum disorder in the Indian population and investi gation of the gene expression in peripheral blood leukocytes. (PubMed id 19647026)1, 4, 9 Guhathakurta S....Usha R. (2009)
    5. Serotonin and dopamine receptor gene polymorphisms and the risk of extrapyramidal side effects in perphenazine-treated schizophrenic patients. (PubMed id 17102980)1, 4, 9 Gunes A....Dahl M.L. (2007)
    6. 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association. (PubMed id 15048642)1, 4, 9 Zhang X.N....Zhang L.N. (2004)
    7. HTR2A variation and sudden infant death syndrome: a case-control analysis. (PubMed id 18771483)1, 4, 9 Rand C.M....Weese-Mayer D.E. (2009)
    8. Serotonin receptor 2A gene polymorphisms and schizoph renia: association with family history, diagnostic subtype and height in patien ts. (PubMed id 19855357)1, 4, 9 Melkersson K. and Hulting A.L. (2009)
    9. Association between HTR2C and HTR2A polymorphisms and metabolic abnormalities in patients treated with olanzapine or clozapine. (PubMed id 19142110)1, 4, 9 Gunes A....Dahl M.L. (2009)
    10. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. (PubMed id 16642436)1, 4, 9 McMahon F.J....Manji H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3356 HGNC: 5293 AceView: HTR2A Ensembl:ENSG00000102468 euGenes: HUgn3356
    ECgene: HTR2A Kegg: 3356 H-InvDB: HTR2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR2A Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HTR2A

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTR2A gene:
    Search GeneIP for patents involving HTR2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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