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Aliases for HTR1F Gene

Aliases for HTR1F Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled 2 3
  • Serotonin Receptor 1F 3 4
  • 5-HT-1F 3 4
  • 5-HT1F 3 4
  • HTR1EL 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1F 2
  • 5HT6 3
  • MR77 3

External Ids for HTR1F Gene

Previous GeneCards Identifiers for HTR1F Gene

  • GC03P088567
  • GC03P090821
  • GC03P087919
  • GC03P087960
  • GC03P088122
  • GC03P088031

Summaries for HTR1F Gene

GeneCards Summary for HTR1F Gene

HTR1F (5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1F include migraine with or without aura 1. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is ADRA1A.

UniProtKB/Swiss-Prot for HTR1F Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1F Gene

  • Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11).

Gene Wiki entry for HTR1F Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1F Gene

Genomics for HTR1F Gene

Regulatory Elements for HTR1F Gene

Genomic Location for HTR1F Gene

Chromosome:
3
Start:
87,792,767 bp from pter
End:
87,994,856 bp from pter
Size:
202,090 bases
Orientation:
Plus strand

Genomic View for HTR1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HTR1F Gene

Proteins for HTR1F Gene

  • Protein details for HTR1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30939-5HT1F_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Protein Accession:
    P30939

    Protein attributes for HTR1F Gene

    Size:
    366 amino acids
    Molecular mass:
    41709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1F Gene

Proteomics data for HTR1F Gene at MOPED

Post-translational modifications for HTR1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR1F Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR1F Gene

Domains & Families for HTR1F Gene

Suggested Antigen Peptide Sequences for HTR1F Gene

Graphical View of Domain Structure for InterPro Entry

P30939

UniProtKB/Swiss-Prot:

5HT1F_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1F: view

Function for HTR1F Gene

Molecular function for HTR1F Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1F,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IMP 21422162
GO:0051378 serotonin binding IDA 8380639
genes like me logo Genes that share ontologies with HTR1F: view
genes like me logo Genes that share phenotypes with HTR1F: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HTR1F Gene

Localization for HTR1F Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1F Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1F Gene COMPARTMENTS Subcellular localization image for HTR1F gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 21422162
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1F: view

Pathways & Interactions for HTR1F Gene

genes like me logo Genes that share pathways with HTR1F: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8380639
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007210 serotonin receptor signaling pathway IMP 21422162
GO:0007268 synaptic transmission TAS 8380639
genes like me logo Genes that share ontologies with HTR1F: view

No data available for SIGNOR curated interactions for HTR1F Gene

Drugs & Compounds for HTR1F Gene

(43) Drugs for HTR1F Gene - From: IUPHAR, ApexBio, DGIdb, NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sumatriptan Approved, Investigational Pharma Antagonist, agonist, Target 92
Naratriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 14
Rizatriptan Approved Pharma Full agonist, Agonist, agonist, Target 34
Zolmitriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 14
Eletriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 19

(7) Additional Compounds for HTR1F Gene - From: IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10-OBn-7alpha-F-gingkolide B
Full agonist, Agonist
5-HT
Inhibition, Inhibitor
alpha-methyl-5-HT
Full agonist, Agonist
LY573144
Full agonist, Agonist
N-Desmethyleletriptan
genes like me logo Genes that share compounds with HTR1F: view

Transcripts for HTR1F Gene

mRNA/cDNA for HTR1F Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1F Gene

5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1F Gene

No ASD Table

Relevant External Links for HTR1F Gene

GeneLoc Exon Structure for
HTR1F
ECgene alternative splicing isoforms for
HTR1F

Expression for HTR1F Gene

mRNA expression in normal human tissues for HTR1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HTR1F Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1F Gene



SOURCE GeneReport for Unigene cluster for HTR1F Gene Hs.248136

genes like me logo Genes that share expression patterns with HTR1F: view

Protein tissue co-expression partners for HTR1F Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HTR1F Gene

Orthologs for HTR1F Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1F Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1F 35
  • 91.35 (n)
  • 94.81 (a)
5HTR1F 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1F 35
  • 92.17 (n)
  • 94.26 (a)
HTR1F 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1f 35
  • 87.95 (n)
  • 94.52 (a)
Htr1f 16
Htr1f 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1F 35
  • 99.73 (n)
  • 100 (a)
HTR1F 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1f 35
  • 87.21 (n)
  • 92.6 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1F 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1F 35
  • 79.06 (n)
  • 83.2 (a)
HTR1F 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1F 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1f 35
  • 73.95 (n)
  • 80.11 (a)
zebrafish
(Danio rerio)
Actinopterygii htr1fa 35
  • 62.94 (n)
  • 64.12 (a)
htf1fb 36
  • 57 (a)
OneToMany
htr1fa 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 43 (a)
5-HT1B 37
  • 42 (a)
5-HT7 37
  • 36 (a)
CG6989 37
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT1B 35
  • 40.02 (n)
  • 31.63 (a)
worm
(Caenorhabditis elegans)
Secernentea C09B7.1a 37
  • 33 (a)
C09B7.1b 37
  • 33 (a)
F14D12.6 37
  • 30 (a)
Species with no ortholog for HTR1F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1F Gene

ENSEMBL:
Gene Tree for HTR1F (if available)
TreeFam:
Gene Tree for HTR1F (if available)

Paralogs for HTR1F Gene

Paralogs for HTR1F Gene

(17) SIMAP similar genes for HTR1F Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR1F: view

Variants for HTR1F Gene

Sequence variations from dbSNP and Humsavar for HTR1F Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1931 -- 87,991,855(+) GTTTT(A/T)AAAAT utr-variant-3-prime
rs6301 -- 87,991,532(+) AAAAT(A/T)CATAG synonymous-codon, reference
rs167260 -- 87,912,547(+) acatt(C/T)ttcac intron-variant
rs167261 -- 87,890,282(+) TATGT(G/T)TGTAC intron-variant
rs169937 -- 87,925,880(+) cttca(A/G)aaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR1F Gene

Variant ID Type Subtype PubMed ID
nsv877146 CNV Loss 21882294

Variation tolerance for HTR1F Gene

Residual Variation Intolerance Score: 17.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1F Gene

HapMap Linkage Disequilibrium report
HTR1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1F Gene

Disorders for HTR1F Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR1F Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association
Search HTR1F in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1F

Genetic Association Database (GAD)
HTR1F
Human Genome Epidemiology (HuGE) Navigator
HTR1F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1F
genes like me logo Genes that share disorders with HTR1F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1F Gene

Publications for HTR1F Gene

  1. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. (PMID: 8380639) Adham N. … Branchek T.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 23 25 67
  2. Genome-wide linkage analysis for smoking-related regions, with replication in two ethnically diverse populations. (PMID: 17763112) Pomerleau O.F. … Kardia S.L. (Nicotine Tob. Res. 2007) 23 67
  3. Distribution of mRNA coding for 5-hydroxytryptamine receptor subtypes in the intestines of healthy dairy cows and dairy cows with cecal dilatation-dislocation. (PMID: 16426218) Engel L. … Meylan M. (Am. J. Vet. Res. 2006) 23 67
  4. Post-triptan era for the treatment of acute migraine. (PMID: 15361324) Goadsby P.J. (Curr Pain Headache Rep 2004) 23 67
  5. Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. (PMID: 15185063) JAohnichen S. … Pertz H.H. (Naunyn Schmiedebergs Arch. Pharmacol. 2004) 25 26

Products for HTR1F Gene

Sources for HTR1F Gene

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