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Aliases for HTR1F Gene

Aliases for HTR1F Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled 2 3
  • HTR1EL 3 4 6
  • Serotonin Receptor 1F 3 4
  • 5-HT-1F 3 4
  • 5-HT1F 3 4
  • MR77 3 6
  • 5-Hydroxytryptamine (Serotonin) Receptor 1F 2
  • 5-Hydroxytryptamine Receptor 1F 3
  • 5HT6 3

External Ids for HTR1F Gene

Summaries for HTR1F Gene

GeneCards Summary for HTR1F Gene

HTR1F (5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity and serotonin binding. An important paralog of this gene is ADRA1A.

UniProtKB/Swiss-Prot for HTR1F Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1F Gene

  • Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The physiological role of 5-HT1F receptors is currently unknown. The human 5-HT1F receptor gene has been localized to chromosome 3 (3q11).

Gene Wiki entry for HTR1F Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1F Gene

Genomics for HTR1F Gene

Genomic Location for HTR1F Gene

Start:
87,792,779 bp from pter
End:
87,994,814 bp from pter
Size:
202,036 bases
Orientation:
Plus strand

Genomic View for HTR1F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1F Gene

Regulatory Elements for HTR1F Gene

Proteins for HTR1F Gene

  • Protein details for HTR1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30939-5HT1F_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Protein Accession:
    P30939
    Secondary Accessions:

    Protein attributes for HTR1F Gene

    Size:
    366 amino acids
    Molecular mass:
    41709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1F Gene

Proteomics data for HTR1F Gene at MOPED

Post-translational modifications for HTR1F Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5 and Asn10

Other Protein References for HTR1F Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1F Gene

Domains for HTR1F Gene

Gene Families for HTR1F Gene

HGNC:
  • HTR :5-HT (serotonin) receptors
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
IUPHAR :

UniProtKB/Swiss-Prot:

5HT1F_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P30939
genes like me logo Genes that share domains with HTR1F: view

Function for HTR1F Gene

Molecular function for HTR1F Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype 1F,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IMP 21422162
GO:0051378 serotonin binding IDA 8380639
genes like me logo Genes that share ontologies with HTR1F: view
genes like me logo Genes that share phenotypes with HTR1F: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR1F Gene

Localization for HTR1F Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1F Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1F Gene COMPARTMENTS Subcellular localization image for HTR1F gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 21422162
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1F: view

Pathways for HTR1F Gene

genes like me logo Genes that share pathways with HTR1F: view

Gene Ontology (GO) - Biological Process for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8380639
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007210 serotonin receptor signaling pathway IMP 21422162
GO:0007268 synaptic transmission TAS 8380639
genes like me logo Genes that share ontologies with HTR1F: view

Compounds for HTR1F Gene

(2) Tocris Compounds for HTR1F Gene

Compound Action Cas Number
LY 334370 hydrochloride Selective 5-HT1F agonist [199673-74-0]
LY 344864 hydrochloride Potent, selective 5-HT1F agonist [186544-26-3]

(2) HMDB Compounds for HTR1F Gene

Compound Synonyms Cas Number PubMed IDs
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9
Sumatriptan
  • Imigran
103628-46-2

(5) Drugbank Compounds for HTR1F Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Eletriptan
143322-58-1 target agonist
Naratriptan
121679-13-8 target agonist
Rizatriptan
  • MK 462 Free Base
145202-66-0 target agonist
Sumatriptan
  • NP101
103628-46-2 target agonist
Zolmitriptan
139264-17-8 target agonist

(40) IUPHAR Ligand for HTR1F Gene

Ligand Type Action Affinity Pubmed IDs
10-OBn-7alpha-F-gingkolide B Agonist Full agonist 9.7
[3H]LY334370 Agonist Full agonist 9.4
NAN 190 Antagonist Antagonist 9.4
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
olanzapine Antagonist Antagonist 9.2
BRL-54443 Agonist Full agonist 8.9
LY573144 Agonist Full agonist 8.7
quetiapine Antagonist Antagonist 8.7
ergotamine Agonist Full agonist 8.6
DOI Agonist Full agonist 8.6
methylergonovine Agonist Full agonist 8.3
1-naphthylpiperazine Agonist Full agonist 8
LY334370 Agonist Full agonist 7.8
risperidone Antagonist Antagonist 7.8
naratriptan Agonist Full agonist 7.6
eletriptan Agonist Full agonist 7.4
metergoline Antagonist Antagonist 7.4
yohimbine Antagonist Antagonist 7.3
tryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
5-MeO-DMT Agonist Full agonist 7
sertindole Antagonist Antagonist 6.9
methysergide Antagonist Antagonist 6.8
5-MeOT Agonist Full agonist 6.8
clozapine Antagonist Antagonist 6.7
zolmitriptan Agonist Full agonist 6.6
rizatriptan Agonist Full agonist 6.4
2-methyl-5-HT Agonist Full agonist 6.4
TFMPP Agonist Full agonist 6.4
LY344864 Agonist Full agonist 6.3
5-CT Agonist Full agonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
GR-127935 Agonist Partial agonist 5.8
alpha-methyl-5-HT Agonist Full agonist 5.8
dipropyl-5-CT Agonist Full agonist 5.8
sumatriptan Antagonist Antagonist 5.6
donitriptan Agonist Partial agonist 5.6
5-HT Inhibitor Inhibition 2.2

(1) Novoseek inferred chemical compound relationships for HTR1F Gene

Compound -log(P) Hits PubMed IDs
sumatriptan 78 2
genes like me logo Genes that share compounds with HTR1F: view

Transcripts for HTR1F Gene

mRNA/cDNA for HTR1F Gene

(9) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1F Gene

5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1F Gene

No ASD Table

Relevant External Links for HTR1F Gene

GeneLoc Exon Structure for
HTR1F
ECgene alternative splicing isoforms for
HTR1F

Expression for HTR1F Gene

mRNA expression in normal human tissues for HTR1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR1F Gene

SOURCE GeneReport for Unigene cluster for HTR1F Gene Hs.248136

genes like me logo Genes that share expressions with HTR1F: view

Orthologs for HTR1F Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR1F 36
  • 99.73 (n)
  • 100 (a)
HTR1F 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia 5HTR1F 37
  • 95 (a)
OneToOne
HTR1F 36
  • 91.35 (n)
  • 94.81 (a)
dog
(Canis familiaris)
Mammalia HTR1F 36
  • 92.17 (n)
  • 94.26 (a)
HTR1F 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1f 36
  • 87.95 (n)
  • 94.52 (a)
Htr1f 16
Htr1f 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1F 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1f 36
  • 87.21 (n)
  • 92.6 (a)
chicken
(Gallus gallus)
Aves HTR1F 36
  • 79.06 (n)
  • 83.2 (a)
HTR1F 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1F 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1f 36
  • 73.95 (n)
  • 80.11 (a)
zebrafish
(Danio rerio)
Actinopterygii htf1fb 37
  • 57 (a)
OneToMany
htr1fa 36
  • 62.94 (n)
  • 64.12 (a)
htr1fa 37
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT1B 36
  • 40.02 (n)
  • 31.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 38
  • 43 (a)
5-HT1B 38
  • 42 (a)
5-HT7 38
  • 36 (a)
CG6989 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea C09B7.1b 38
  • 33 (a)
C09B7.1a 38
  • 33 (a)
F14D12.6 38
  • 30 (a)
Species with no ortholog for HTR1F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1F Gene

ENSEMBL:
Gene Tree for HTR1F (if available)
TreeFam:
Gene Tree for HTR1F (if available)

Paralogs for HTR1F Gene

Paralogs for HTR1F Gene

Selected SIMAP similar genes for HTR1F Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR1F: view

Variants for HTR1F Gene

Sequence variations from dbSNP and Humsavar for HTR1F Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1931 -- 87,991,855(+) GTTTT(A/T)AAAAT utr-variant-3-prime
rs6301 -- 87,991,532(+) AAAAT(A/T)CATAG synonymous-codon, reference
rs167260 -- 87,912,547(+) acatt(C/T)ttcac intron-variant
rs167261 -- 87,890,282(+) TATGT(G/T)TGTAC intron-variant
rs169937 -- 87,925,880(+) cttca(A/G)aaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR1F Gene

Variant ID Type Subtype PubMed ID
nsv877146 CNV Loss 21882294

Relevant External Links for HTR1F Gene

HapMap Linkage Disequilibrium report
HTR1F

Disorders for HTR1F Gene

(1) University of Copenhagen DISEASES for HTR1F Gene

(1) Novoseek inferred disease relationships for HTR1F Gene

Disease -log(P) Hits PubMed IDs
migraine 54.5 3

Relevant External Links for HTR1F

Genetic Association Database (GAD)
HTR1F
Human Genome Epidemiology (HuGE) Navigator
HTR1F
genes like me logo Genes that share disorders with HTR1F: view

No data available for UniProtKB/Swiss-Prot for HTR1F Gene

Publications for HTR1F Gene

  1. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. (PMID: 8380639) Adham N. … Branchek T.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23
  2. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. (PMID: 8384716) Lovenberg T.W. … Sutcliffe G.J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  3. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PMID: 12627464) Turecki G. … Rouleau G.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 49

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