Aliases for HTR1F Gene
External Ids for HTR1F Gene
Previous GeneCards Identifiers for HTR1F Gene
GeneCards Summary for HTR1F Gene
HTR1F (5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity and serotonin binding. An important paralog of this gene is ADRA1A.
UniProtKB/Swiss-Prot for HTR1F Gene
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The physiological role of 5-HT1F receptors is currently unknown. The human 5-HT1F receptor gene has been localized to chromosome 3 (3q11).