Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HTR1F Gene

Aliases for HTR1F Gene

  • 5-Hydroxytryptamine Receptor 1F 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled 2 3
  • Serotonin Receptor 1F 3 4
  • 5-HT-1F 3 4
  • 5-HT1F 3 4
  • HTR1EL 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1F 2
  • 5HT6 3
  • MR77 3

External Ids for HTR1F Gene

Previous GeneCards Identifiers for HTR1F Gene

  • GC03P088567
  • GC03P090821
  • GC03P087919
  • GC03P087960
  • GC03P088122
  • GC03P088031

Summaries for HTR1F Gene

GeneCards Summary for HTR1F Gene

HTR1F (5-Hydroxytryptamine Receptor 1F) is a Protein Coding gene. Diseases associated with HTR1F include Migraine With Or Without Aura 1. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1E.

UniProtKB/Swiss-Prot for HTR1F Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1F Gene

  • Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11).

Gene Wiki entry for HTR1F Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1F Gene

Genomics for HTR1F Gene

Regulatory Elements for HTR1F Gene

Enhancers for HTR1F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F087795 1.2 Ensembl ENCODE 9.3 +4.5 4508 4.2 PKNOX1 ATF1 ARNT GATA2 FOS JUNB NCOA1 MBD2 MEF2D SMARCA4 HTR1F CGGBP1 LOC105377198 PIR56827
GH03F087791 0.9 ENCODE 8.9 +0.6 596 2.9 GLIS2 ZNF202 ZNF680 HCFC1 REST ZNF518A ZNF781 ZNF264 SMARCA4 AEBP2 CGGBP1 ZNF654 HTR1F LOC105377198
GH03F087800 0.7 ENCODE 9.1 +8.2 8230 1.9 SMARCE1 PKNOX1 TAL1 ZEB2 DPF2 ARID1B FOXK2 HDAC2 GATA2 NCOR1 HTR1F CGGBP1 LOC105377198 PIR56827
GH03F088030 1.3 FANTOM5 Ensembl ENCODE 4.4 +239.0 239034 3.6 TBP IRF2 ASH2L ZBTB40 YY1 ZNF316 FOXK2 POLR2A STAT2 MAFK CGGBP1 ZNF654 HTR1F C3orf38 GC03P088032 RNU6ATAC6P
GH03F088033 1 Ensembl ENCODE 4.4 +241.5 241521 1.3 ZNF263 PKNOX1 STAT1 DDX20 TAL1 DPF2 ARID1B JUND POLR2A NCOR1 CGGBP1 HTR1F GC03P088032 GC03P088045
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR1F on UCSC Golden Path with GeneCards custom track

Promoters for HTR1F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001368470 234 1999 GLIS2 REST SMARCA4 ZNF341 IKZF1 GLIS1 KDM1A PRDM1 ZBTB26 MGA

Genomic Location for HTR1F Gene

Chromosome:
3
Start:
87,792,767 bp from pter
End:
87,994,856 bp from pter
Size:
202,090 bases
Orientation:
Plus strand

Genomic View for HTR1F Gene

Genes around HTR1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1F Gene

Proteins for HTR1F Gene

  • Protein details for HTR1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30939-5HT1F_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1F
    Protein Accession:
    P30939

    Protein attributes for HTR1F Gene

    Size:
    366 amino acids
    Molecular mass:
    41709 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1F Gene

Post-translational modifications for HTR1F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR1F Gene

No data available for DME Specific Peptides for HTR1F Gene

Domains & Families for HTR1F Gene

Suggested Antigen Peptide Sequences for HTR1F Gene

Graphical View of Domain Structure for InterPro Entry

P30939

UniProtKB/Swiss-Prot:

5HT1F_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1F: view

Function for HTR1F Gene

Molecular function for HTR1F Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1F,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IMP,IDA 21422162
GO:0030594 neurotransmitter receptor activity IBA --
GO:0051378 serotonin binding IDA 8380639
genes like me logo Genes that share ontologies with HTR1F: view
genes like me logo Genes that share phenotypes with HTR1F: view

Animal Models for HTR1F Gene

MGI Knock Outs for HTR1F:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR1F

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR1F

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR1F Gene

Localization for HTR1F Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1F Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR1F gene
Compartment Confidence
plasma membrane 5
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP,TAS 21422162
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA --
genes like me logo Genes that share ontologies with HTR1F: view

Pathways & Interactions for HTR1F Gene

genes like me logo Genes that share pathways with HTR1F: view

Gene Ontology (GO) - Biological Process for HTR1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8380639
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with HTR1F: view

No data available for SIGNOR curated interactions for HTR1F Gene

Drugs & Compounds for HTR1F Gene

(45) Drugs for HTR1F Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 5-HT1 receptor agonist 99
Naratriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 14
Rizatriptan Approved Pharma Full agonist, Agonist, agonist, Target 35
Zolmitriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 17
Eletriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 19

(6) Additional Compounds for HTR1F Gene - From: IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
10-OBn-7alpha-F-gingkolide B
Full agonist, Agonist
5-HT
Full agonist, Agonist
alpha-methyl-5-HT
Full agonist, Agonist
LY573144
Full agonist, Agonist
N-Desmethyleletriptan

(2) Tocris Compounds for HTR1F Gene

Compound Action Cas Number
LY 334370 hydrochloride Selective 5-HT1F agonist 199673-74-0
LY 344864 hydrochloride Potent, selective 5-HT1F agonist 1217756-94-9

(4) ApexBio Compounds for HTR1F Gene

Compound Action Cas Number
BRL-54443 5-HT1E/1F receptor agonist,potent and selective 57477-39-1
Lasmiditan 5-HT1F receptor agonist 439239-90-4
LY 334370 hydrochloride 199673-74-0
LY 344864 5-HT1F receptor agonist,potent and selective 186544-26-3
genes like me logo Genes that share compounds with HTR1F: view

Transcripts for HTR1F Gene

mRNA/cDNA for HTR1F Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1F Gene

5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR1F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1F Gene

No ASD Table

Relevant External Links for HTR1F Gene

GeneLoc Exon Structure for
HTR1F
ECgene alternative splicing isoforms for
HTR1F

Expression for HTR1F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTR1F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HTR1F Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1F Gene



Protein tissue co-expression partners for HTR1F Gene

NURSA nuclear receptor signaling pathways regulating expression of HTR1F Gene:

HTR1F

SOURCE GeneReport for Unigene cluster for HTR1F Gene:

Hs.248136
genes like me logo Genes that share expression patterns with HTR1F: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HTR1F Gene

Orthologs for HTR1F Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR1F 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia 5HTR1F 35
  • 95 (a)
OneToOne
HTR1F 34
  • 91.35 (n)
dog
(Canis familiaris)
Mammalia HTR1F 34 35
  • 92.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1F 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1f 34 16 35
  • 87.95 (n)
rat
(Rattus norvegicus)
Mammalia Htr1f 34
  • 87.21 (n)
chicken
(Gallus gallus)
Aves HTR1F 34 35
  • 79.06 (n)
lizard
(Anolis carolinensis)
Reptilia HTR1F 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1f 34
  • 73.95 (n)
zebrafish
(Danio rerio)
Actinopterygii htr1fa 34 35
  • 62.94 (n)
htf1fb 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 36
  • 43 (a)
5-HT1B 36
  • 42 (a)
5-HT7 36
  • 36 (a)
CG6989 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT1B 34
  • 40.02 (n)
worm
(Caenorhabditis elegans)
Secernentea C09B7.1a 36
  • 33 (a)
C09B7.1b 36
  • 33 (a)
F14D12.6 36
  • 30 (a)
Species where no ortholog for HTR1F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1F Gene

ENSEMBL:
Gene Tree for HTR1F (if available)
TreeFam:
Gene Tree for HTR1F (if available)

Paralogs for HTR1F Gene

(17) SIMAP similar genes for HTR1F Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR1F: view

Variants for HTR1F Gene

Sequence variations from dbSNP and Humsavar for HTR1F Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1021336 -- 87,815,989(+) TGAAA(G/T)GCACT intron-variant
rs1021338 -- 87,863,713(-) tggcc(C/T)tggaa intron-variant
rs1021339 -- 87,863,596(-) aaact(A/C)agaag intron-variant
rs1021845 -- 87,862,926(-) agcag(C/G)ataat intron-variant
rs1021846 -- 87,863,610(+) CTAGC(A/G)GTTAt intron-variant

Variation tolerance for HTR1F Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR1F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HTR1F Gene

Disorders for HTR1F Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR1F Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards
Search HTR1F in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1F

Genetic Association Database (GAD)
HTR1F
Human Genome Epidemiology (HuGE) Navigator
HTR1F
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1F
genes like me logo Genes that share disorders with HTR1F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1F Gene

Publications for HTR1F Gene

  1. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. (PMID: 8380639) Adham N. … Branchek T.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
  2. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. (PMID: 8384716) Lovenberg T.W. … Sutcliffe G.J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  3. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. (PMID: 21422162) Klein M.T. … Teitler M. (J. Pharmacol. Exp. Ther. 2011) 3 4 64
  4. Association study of the serotoninergic system in migraine in the Spanish population. (PMID: 19455600) Corominas R. … Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for HTR1F Gene

Sources for HTR1F Gene

Content
Loading form....