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HTR1F Gene

protein-coding   GIFtS: 64
GCID: GC03P088031

5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1F)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1F, G Protein-Coupled1 2     MR772 5
HTR1EL2 3 5     5-Hydroxytryptamine (Serotonin) Receptor 1F1
Serotonin Receptor 1F2 3     5-Hydroxytryptamine Receptor 1F2
5-HT-1F2 3     5HT62
5-HT1F2 3     

External Ids:    HGNC: 52921   Entrez Gene: 33552   Ensembl: ENSG000001790977   OMIM: 1821345   UniProtKB: P309393   

Export aliases for HTR1F gene to outside databases

Previous GC identifers: GC03P088567 GC03P090821 GC03P087919 GC03P087960 GC03P088122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HTR1F Gene:
HTR1F (5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled) is a protein-coding gene. GO annotations related to this gene include serotonin binding and serotonin receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
adenylate cyclase. Signaling inhibits adenylate cyclase activity

summary for HTR1F Gene:
Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the
hippocampus, cortex and dorsal raphe nucleus. The physiological role of 5-HT1F receptors is currently
unknown. The human 5-HT1F receptor gene has been localized to chromosome 3 (3q11).

Gene Wiki entry for HTR1F (5-HT1F receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR1F gene promoter:
         Sox5   C/EBPbeta   Pbx1a   AML1a   Pax-2   Pax-2a   CUTL1   Evi-1   S8   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1F promoter sequence
   Search Chromatin IP Primers for HTR1F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12   Ensembl cytogenetic band:  3p11.1   HGNC cytogenetic band: 3p12

HTR1F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1F gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P088031:  view genomic region     (about GC identifiers)

Start:
88,031,726 bp from pter      End:
88,042,919 bp from pter
Size:
11,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1F  
Size: 366 amino acids; 41709 Da

Explore the universe of human proteins at neXtProt for HTR1F: NX_P30939

Explore proteomics data for HTR1F at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn10
  • Modification sites at PhosphoSitePlus

  • See HTR1F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000857.1  
    ENSEMBL proteins: 
     ENSP00000322924  
    Reactome Protein details: P30939

    HTR1F Human Recombinant Protein Products:

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    antibodies-online proteins for HTR1F (4 products) 

     
    antibodies-online peptides for HTR1F

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1F receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000450 5HT1F_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30939

    ProtoNet protein and cluster: P30939

    2 Blocks protein domains:
    IPB000450 5-hydroxytryptamine 1F receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1F_HUMAN, P30939
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HTR1F           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1F_HUMAN, P30939
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
    guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
    adenylate cyclase. Signaling inhibits adenylate cyclase activity

         Genatlas biochemistry entry for HTR1F:
    5-hydroxytryptamine (serotonin) receptor,subtype 1F,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IMP--
    GO:0051378serotonin binding IDA8380639
         
    Find genes that share ontologies with HTR1F           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR1F:
     Increased viability after born 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Htr1f):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with HTR1F           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Htr1ftm1(KOMP)Vlcg for HTR1F

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    hsa-miR-374b* hsa-miR-3163 hsa-miR-3607-3p hsa-miR-607 hsa-miR-448 hsa-miR-576-5p hsa-miR-4328 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidHTR1F 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT1F_HUMAN, P30939: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HTR1F           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR1F About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33


    Find genes that share SuperPaths with HTR1F           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR1F
        Intracellular Calcium Signaling

    3 BioSystems Pathways for HTR1F
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR1F
        Serotonin receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for HTR1F
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HTR1F):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1F: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HTR1F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR1F (P309393 ENSP000003229244) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8380639
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP--
    GO:0007210serotonin receptor signaling pathway IMP--
    GO:0007268synaptic transmission TAS8380639

    Find genes that share ontologies with HTR1F           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HTR1F available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 334370 hydrochlorideSelective 5-HT1F agonist[199673-74-0]
    LY 344864 hydrochloride Potent, selective 5-HT1F agonist [186544-26-3]

    2 HMDB Compounds for HTR1F    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    SumatriptanImigran (see all 4)103628-46-2--

    5 DrugBank Compounds for HTR1F    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SumatriptanNP101 (see all 4)103628-46-2targetagonist12110114 18723285 10073743 11015308 11752352 10225363 10367177 15178373
    Naratriptan-- 121679-13-8targetagonist12463278 12434581 15320857 14614913 14725972 11152011 11752352
    Zolmitriptan-- 139264-17-8targetagonist12434581 15320857 11834243 9718276 15096229 11752352
    RizatriptanMK 462 Free Base (see all 4)145202-66-0targetagonist12434581 15320857 9718276 14614913 11752352
    Eletriptan-- 143322-58-1targetagonist11834243 15185063 10193663

    Selected IUPHAR Ligands for HTR1F (5-HT1F receptor) (see all 40)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]LY334370
    AgonistFull agonist9.415900510
    BRL-54443
    AgonistFull agonist8.9--
    LY573144
    AgonistFull agonist8.720855361
    LY334370
    AgonistFull agonist8.715900510
    LY344864
    AgonistFull agonist8.29395253
    methysergide
    AntagonistAntagonist8.215900510 8380639
    naratriptan
    AgonistFull agonist8.215900510 10193663
    eletriptan
    AgonistFull agonist810193663
    5-HT
    AgonistFull agonist7.7 - 815900510 8380639 9225282
    10-OBn-7alpha-F-gingkolide B
    AgonistFull agonist7.2 - 7.9--

    1 Novoseek inferred chemical compound relationship for HTR1F gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sumatriptan 78 2 8700126 (1), 8720594 (1)



    Find genes that share compounds with HTR1F           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HTR1F gene: 
    NM_000866.3  

    Unigene Cluster for HTR1F:

    5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
    Hs.248136  [show with all ESTs]
    Unigene Representative Sequence: NM_000866
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000319595(uc021xbd.1)
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      QuantiTect SYBR Green Assays in human, mouse, rat HTR1F
      QuantiFast Probe-based Assays in human, mouse, rat HTR1F

    Additional mRNA sequence: 

    AF498981.1 BC069125.1 BC096838.1 

    2 DOTS entries:

    DT.92061708  DT.100747290 

    10 AceView cDNA sequences:

    CR606112 NM_000866 BC069125 AF498981 BM312885 CB565886 CA942859 CA942616 
    BM313179 AV758122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR1F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR1F Expression
    About this image


    HTR1F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
    HTR1F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR1F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248136
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1F: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR1F gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1f1 , 5 5-hydroxytryptamine (serotonin) receptor 1F1, 5 87.95(n)1
    94.52(a)1
      16 (37.10 cM)5
    155571  NM_008310.31  NP_032336.11 
     649247295 
    chicken
    (Gallus gallus)
    Aves HTR1F1 5-hydroxytryptamine (serotonin) receptor 1F 79.06(n)
    83.2(a)
      427963  XM_004938334.1  XP_004938391.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1F6
    5-hydroxytryptamine (serotonin) receptor 1F, G pro...
    77(a)
    1 ↔ 1
    3(161884806-161885927)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr1f1 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 73.95(n)
    80.11(a)
      100494586  XM_002931771.2  XP_002931817.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr1fa1 5-hydroxytryptamine (serotonin) receptor 1Fa 62.94(n)
    64.12(a)
      100005344  XM_001344394.2  XP_001344430.1 
    mosquito
    (Anopheles gambiae)
    Insecta GPR5HT1B1 GPR5HT1B 40.02(n)
    31.63(a)
      1278365  XM_317820.5  XP_317820.4 


    ENSEMBL Gene Tree for HTR1F (if available)
    TreeFam Gene Tree for HTR1F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR1F gene
    HTR1A2  ADRA1B2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    17 SIMAP similar genes for HTR1F using alignment to 2 protein entries:     5HT1F_HUMAN (see all proteins):
    HTR1E    HTR1D    HTR1B    5HT1A    HTR1A    HTR5A
    ADRA1D    HTR7    ADRA1B    HTR2A    HTR2C    ADRA1A
    DRD3    H4    ADRA2C    ADRB1    DRD5P1

    Find genes that share paralogs with HTR1F           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR1F (see all 288)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20822261,2
    C,H--88029726(+) TCCCTG/AGCTTG 1 -- us2k16Minor allele frequency- A:0.23NS NA EA 366
    rs1417901261,2
    C--88029739(+) CATGGA/GGTTTC 1 -- us2k10--------
    rs1454493631,2
    C--88029768(+) TCCACC/TCAGGA 1 -- us2k10--------
    rs30581721,2
    C--88029828(+) TGTAC-/ATG   
      C
    /CATG
    TGAGG
    1 -- us2k11NA 2
    rs1380096311,2
    C--88029855(+) CACCTA/GGCTGC 1 -- us2k10--------
    rs770509611,2
    F--88029875(+) CCCCTC/TGGCCT 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1493813341,2
    --88029876(+) CCCTCA/GGCCTC 1 -- us2k10--------
    rs766667971,2
    F--88029963(+) GCACAC/TACACA 1 -- us2k12Minor allele frequency- T:0.02CSA WA 120
    rs563239671,2
    C,F--88030136(+) GGCTGC/TTGCTG 1 -- us2k17Minor allele frequency- T:0.26WA NA CSA EA 364
    rs1447172261,2
    C--88030212(+) GCTCCC/TGCCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR1F (88031726 - 88042919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR1F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877146CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR1F
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR1F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182134    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HTR1F:
    Migraine

    Find genes that share disorders with HTR1F           About GenesLikeMe

    1 Novoseek inferred disease relationship for HTR1F gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 54.5 3 9949863 (2), 9225282 (1)

    Genetic Association Database (GAD): HTR1F
    Human Genome Epidemiology (HuGE) Navigator: HTR1F (6 documents)

    Export disorders for HTR1F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR1F gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with HTR1F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. (PubMed id 8380639)1, 2, 3, 9 Adham N.... Branchek T.A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. (PubMed id 8384716)1, 2, 3 Lovenberg T.W.... Sutcliffe G.J. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    6. Association study of seven polymorphisms in four serotonin receptor genes on suicide victims. (PubMed id 16856120)1, 4 Videtic A....Komel R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)1, 4 Turecki G....Rouleau G.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    9. Serotonin receptors - from molecular biology to clinical applications. (PubMed id 20945968)2 Pytliak M.... Felsoci M. (Physiol. Res. 2011)
    10. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. (PubMed id 21422162)2 Klein M.T.... Teitler M. (J. Pharmacol. Exp. Ther. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3355 HGNC: 5292 AceView: HTR1F Ensembl:ENSG00000179097 euGenes: HUgn3355
    ECgene: HTR1F Kegg: 3355 H-InvDB: HTR1F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR1F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR1F gene:
    Search GeneIP for patents involving HTR1F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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