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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR1E Gene

protein-coding   GIFtS: 65
GCID: GC06P087647

5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled1 2     S312 3
Serotonin Receptor 1E2 3     5-Hydroxytryptamine (Serotonin) Receptor 1E1
5-HT-1E2 3     5-Hydroxytryptamine Receptor 1E2
5-HT1E2 3     

External Ids:    HGNC: 52911   Entrez Gene: 33542   Ensembl: ENSG000001688307   OMIM: 1821325   UniProtKB: P285663   

Export aliases for HTR1E gene to outside databases

Previous GC identifers: GC06P087593 GC06P087643 GC06P087704 GC06P084863


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HTR1E Gene: 
HTR1E (5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1E include skin papilloma, and chronic fatigue syndrome, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include serotonin binding and G-protein coupled receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins that inhibit adenylate cyclase activity

summary for HTR1E Gene:
Serotonin 5-ht1E receptors are primarily located in the cortex, caudate putamen, claustrum, hippocampus, and
amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15). The function of this
receptor has yet to be elucidated.

Gene Wiki entry for HTR1E (5-HT1E receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007299.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HTR1E
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1E promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR1E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q14-q15

HTR1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P087647:  view genomic region     (about GC identifiers)

Start:
87,647,024 bp from pter      End:
87,726,401 bp from pter
Size:
79,378 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1E  
Size: 365 amino acids; 41682 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: E1P503 Q9P1Y1

Explore the universe of human proteins at neXtProt for HTR1E: NX_P28566

Explore proteomics data for HTR1E at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28566

  • HTR1E Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTR1E Protein Expression
    REFSEQ proteins: NP_000856.1  
    ENSEMBL proteins: 
     ENSP00000358597   ENSP00000307766  
    Reactome Protein details: P28566
    Human Recombinant Protein Products for HTR1E: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR1E 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IMP--
    GO:0016021integral to membrane ----

    HTR1E for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-ht1e receptor 
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR027425 5HT1E_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28566

    ProtoNet protein and cluster: P28566

    1 Blocks protein domain: IPB002231 5-hydroxytryptamine receptor signature

    UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR1E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1E_HUMAN, P28566
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins that inhibit adenylate cyclase activity

         Genatlas biochemistry entry for HTR1E:
    5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate
    cyclase

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS1733778
    GO:0004993serotonin receptor activity IMP--
    GO:0051378serotonin binding IDA1608964
         
    HTR1E for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidHTR1E 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HTR1E About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.36
    Amine ligand-binding receptors0.79
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics0.33
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1E
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR1E
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/8        Reactome Pathways for HTR1E (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    Serotonin receptors

    1 PharmGKB Pathway for HTR1E
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for HTR1E):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR1E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/145 Interacting proteins for HTR1E (P285663 ENSP000003077664) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC3P179803, ENSP000002988524I2D: score=2 STRING: ENSP00000298852
    PSMC4P436863, ENSP000001578124I2D: score=2 STRING: ENSP00000157812
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADRA2BENSP000003872814STRING: ENSP00000387281
    DRD2ENSP000003548594STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS1608964
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1733778
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP--
    GO:0007210serotonin receptor signaling pathway IMP--
    GO:0007268synaptic transmission IEA--

    HTR1E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR1E for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HTR1E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRL 54443Potent 5-ht1E/F agonist[57477-39-1]

    1 HMDB Compound for HTR1E    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    6 DrugBank Compounds for HTR1E    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Eletriptan-- 143322-58-1targetagonist17139284 17016423
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist17848919
    Clozapine-- 5786-21-0targetantagonist17848919
    Olanzapine-- 132539-06-1targetantagonist17848919
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7targetother/unknown17848919
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist17848919

    10/46 IUPHAR Ligands for HTR1E (5-ht1e receptor) (see all 46)    About this table 
    LigandTypeActionAffinityPubmed IDs
    BRL-54443
    AgonistFull agonist8.7--
    [3H]5-HT
    AgonistFull agonist8.1 - 8.28863519 1608964
    5-HT
    AgonistFull agonist8 - 8.28380639 15110837 14744596 1608964
    asenapine
    AgonistFull agonist88935801
    zolmitriptan
    AgonistFull agonist7.710193663
    naratriptan
    AgonistFull agonist7.710193663
    lysergol
    AgonistFull agonist7.48863519
    ergonovine
    AgonistFull agonist7.314744596
    eletriptan
    AgonistFull agonist7.210193663
    methylergonovine
    AntagonistAntagonist7 - 7.28380639 15110837

    6 Novoseek inferred chemical compound relationships for HTR1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-carboxamidotryptamine 83.8 1 1513320 (1)
    5-hydroxytryptamine 76.5 4 8883928 (1), 1513320 (1)
    methysergide 75.6 1 1513320 (1)
    ergotamine 75 1 1513320 (1)
    guanine 46.8 1 8450834 (1)
    oligonucleotide 29.1 1 9316030 (1)

    Search CenterWatch for drugs/clinical trials and news about HTR1E / 5HT1E

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for HTR1E gene: 
    NM_000865.2  

    Unigene Cluster for HTR1E:

    5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
    Hs.1611  [show with all ESTs]
    Unigene Representative Sequence: NM_000865
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369584 ENST00000305344(uc003pli.3)
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    Additional mRNA sequence: 

    AF498980.1 BC069751.1 M91467.1 

    3 DOTS entries:

    DT.91739998  DT.100670613  DT.100661910 

    24/25 AceView cDNA sequences (see all 25):

    BC069751 CR596923 CR618239 CR606192 BX349901 AF498980 AL520002 M91467 
    AL521494 NM_000865 AL522462 BX389401 BX355486 AL561841 AL520435 CB565887 
    AL561877 AL519220 AL521170 AI807334 AL522463 AL521493 AI479667 AL521169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGATGGG
    HTR1E Expression
    About this image


    See HTR1E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR1E

    SOURCE GeneReport for Unigene cluster: Hs.1611
        SABiosciences Expression via Pathway-Focused PCR Array including HTR1E: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HTR1E gene from 7/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HTR1E1 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 90.5(n)
    94.52(a)
      481907  XM_539028.1  XP_539028.1 
    chicken
    (Gallus gallus)
    Aves HTR1E1 5-hydroxytryptamine (serotonin) receptor 1E 75.73(n)
    86.81(a)
      771973  XM_001235178.1  XP_001235179.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1E6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    1(176521736-176522830)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221722 Xenopus laevis transcribed sequence with moderate similarity more 72.19(n)    48025952 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003306811 5-hydroxytryptamine receptor 1E-like 65.93(n)
    68.14(a)
      100330681  XM_002665643.1  XP_002665689.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT1A3 serotonin receptor signaling pathway
    G-protein more
    43(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33 G-protein coupled receptor 37(a)   X(4985611-4990413)   --


    ENSEMBL Gene Tree for HTR1E (if available)
    TreeFam Gene Tree for HTR1E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR1E gene
    HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  
    HTR2C2  ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR5A2  HTR1B2  
    16 SIMAP similar genes for HTR1E using alignment to 1 protein entry:     5HT1E_HUMAN:
    HTR1F    HTR1D    HTR1B    5HT1A    HTR1A    HTR5A
    ADRA1D    HTR7    HTR2C    ADRA1A    HTR2A    ADRA1B
    DRD3    ADRB1    DRD1    HRH2

    HTR1E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1514 SNPs in HTR1E are shown (see all 1514)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420013311,2
    Cuntested187725851(+) TCCCCA/C/TCCTTC 2 P S mis10--------
    rs716529781,2
    C--84899619(+) GTGGCTGTGTG/-
            
    TGTGT
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1134630671,2
    C,F--87645033(+) AAGTTT/GCCCCA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1181253731,2
    C,F--87645148(+) TGATGA/TCTTTT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1486217051,2
    --87645189(+) CCTTAC/TAGTTT 1 -- us2k10--------
    rs753834571,2
    C,F--87645345(+) TTATTA/GAAACT 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1420582151,2
    --87645362(+) ATATAC/TGCCAG 1 -- us2k10--------
    rs1511306071,2
    C--87645430(+) AAAGCA/GGGTAT 1 -- us2k10--------
    rs1916207781,2
    --87645435(+) GGGTAC/TTCTGA 1 -- us2k10--------
    rs1406117691,2
    C--87645490(+) AGTTCC/TTTATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR1E (87647024 - 87726401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HTR1E:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2444959CNV Deletion19546169
    esv267623CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182132    OMIM disorders: --

    5 diseases for HTR1E:    About MalaCards
    skin papilloma    chronic fatigue syndrome    papilloma    attention deficit hyperactivity disorder
    autism spectrum disorder

    1 disease from the University of Copenhagen DISEASES database for HTR1E:
    Skin papilloma

    HTR1E for disorders           About GeneDecksing

    Genetic Association Database (GAD): HTR1E
    Human Genome Epidemiology (HuGE) Navigator: HTR1E (9 documents)

    Export disorders for HTR1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR1E gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with HTR1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. (PubMed id 1608964)1, 2, 3 McAllister G.... Whiting P. (1992)
    2. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. (PubMed id 1733778)1, 2, 9 Levy F.O.... Birnbaumer L. (1992)
    3. Human gene S31 encodes the pharmacologically defined serotonin 5- hydroxytryptamine1E receptor. (PubMed id 1513320)1, 2, 9 Zgombick J.M....Weinshank R.L. (1992)
    4. Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    6. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    7. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. (PubMed id 18937842)1, 4 Oades R.D....Asherson P. (2008)
    8. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    9. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (2008)
    10. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. (PubMed id 18079067)1, 4 Smith A.K....Rajeevan M.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3354 HGNC: 5291 AceView: HTR1E Ensembl:ENSG00000168830 euGenes: HUgn3354
    ECgene: HTR1E Kegg: 3354 H-InvDB: HTR1E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR1E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTR1E gene:
    Search GeneIP for patents involving HTR1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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