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Aliases for HTR1E Gene

Aliases for HTR1E Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled 2 3
  • Serotonin Receptor 1E 3 4
  • 5-HT-1E 3 4
  • 5-HT1E 3 4
  • S31 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1E 2

External Ids for HTR1E Gene

Previous GeneCards Identifiers for HTR1E Gene

  • GC06P087593
  • GC06P087643
  • GC06P087704
  • GC06P087647
  • GC06P084863

Summaries for HTR1E Gene

GeneCards Summary for HTR1E Gene

HTR1E (5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1E include attention deficit-hyperactivity disorder. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1E Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1E Gene

  • Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15); the receptor is closely related to the serotonin 5-HT1F receptor.

Gene Wiki entry for HTR1E Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1E Gene

Genomics for HTR1E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR1E Gene

Chromosome:
6
Start:
86,937,306 bp from pter
End:
87,016,683 bp from pter
Size:
79,378 bases
Orientation:
Plus strand

Genomic View for HTR1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1E Gene

No data available for Regulatory Elements for HTR1E Gene

Proteins for HTR1E Gene

  • Protein details for HTR1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28566-5HT1E_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1E
    Protein Accession:
    P28566
    Secondary Accessions:
    • E1P503
    • Q9P1Y1

    Protein attributes for HTR1E Gene

    Size:
    365 amino acids
    Molecular mass:
    41682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1E Gene

Proteomics data for HTR1E Gene at MOPED

Post-translational modifications for HTR1E Gene

  • Glycosylation at Asn 2 and Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR1E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR1E Gene

Domains & Families for HTR1E Gene

Protein Domains for HTR1E Gene

Suggested Antigen Peptide Sequences for HTR1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28566

UniProtKB/Swiss-Prot:

5HT1E_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1E: view

Function for HTR1E Gene

Molecular function for HTR1E Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 1733778
GO:0004993 serotonin receptor activity IMP 21422162
GO:0005515 protein binding IPI 25416956
GO:0051378 serotonin binding IDA 1608964
genes like me logo Genes that share ontologies with HTR1E: view
genes like me logo Genes that share phenotypes with HTR1E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTR1E Gene

Localization for HTR1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1E Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1E Gene COMPARTMENTS Subcellular localization image for HTR1E gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 21422162
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1E: view

Pathways & Interactions for HTR1E Gene

genes like me logo Genes that share pathways with HTR1E: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 1608964
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1733778
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007210 serotonin receptor signaling pathway IMP 21422162
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR1E: view

No data available for SIGNOR curated interactions for HTR1E Gene

Drugs & Compounds for HTR1E Gene

(53) Drugs for HTR1E Gene - From: IUPHAR, DGIdb, ApexBio, DrugBank, HMDB, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ziprasidone Approved Pharma Antagonist, agonist, Target, antagonist 139
Methysergide Approved Pharma Antagonist, antagonist, Target, binder 0
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication 108
Eletriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 19
Olanzapine Approved, Investigational Pharma Antagonist, agonist, Target, antagonist 369

(7) Additional Compounds for HTR1E Gene - From: IUPHAR, Tocris, NovoSeek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
<i>m</i>-CPP
Partial agonist, Agonist
5-HT
Inhibition, Inhibitor
alpha-methyl-5-HT
Full agonist, Agonist
N-Desmethyleletriptan
BRL 54443
57477-39-1
genes like me logo Genes that share compounds with HTR1E: view

Transcripts for HTR1E Gene

mRNA/cDNA for HTR1E Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1E Gene

5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1E

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1E Gene

No ASD Table

Relevant External Links for HTR1E Gene

GeneLoc Exon Structure for
HTR1E
ECgene alternative splicing isoforms for
HTR1E

Expression for HTR1E Gene

mRNA expression in normal human tissues for HTR1E Gene

mRNA differential expression in normal tissues according to GTEx for HTR1E Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x7.6), Brain - Cortex (x6.4), Brain - Anterior cingulate cortex (BA24) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.1).

SOURCE GeneReport for Unigene cluster for HTR1E Gene Hs.1611

mRNA Expression by UniProt/SwissProt for HTR1E Gene

P28566-5HT1E_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expression patterns with HTR1E: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HTR1E Gene

Orthologs for HTR1E Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1E 35
  • 89.13 (n)
  • 95.07 (a)
HTR1E 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1E 35
  • 90.5 (n)
  • 94.52 (a)
HTR1E 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1E 35
  • 99.54 (n)
  • 100 (a)
HTR1E 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTR1E 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr5b 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HTR1E 35
  • 75.73 (n)
  • 86.81 (a)
HTR1E 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1E 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1e 35
  • 71.88 (n)
  • 82.68 (a)
Str.3647 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22172 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330681 35
  • 65.93 (n)
  • 68.14 (a)
HTR1E 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 43 (a)
5-HT1B 37
  • 42 (a)
5-HT7 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 37 (a)
Species with no ortholog for HTR1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1E Gene

ENSEMBL:
Gene Tree for HTR1E (if available)
TreeFam:
Gene Tree for HTR1E (if available)

Paralogs for HTR1E Gene

Paralogs for HTR1E Gene

(16) SIMAP similar genes for HTR1E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1E: view

Variants for HTR1E Gene

Sequence variations from dbSNP and Humsavar for HTR1E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6302 -- 87,015,865(+) CAGCA(C/T)GACCA reference, synonymous-codon
rs6303 - 87,016,119(+) TGCCT(C/T)CATCA reference, missense
rs718166 -- 86,983,905(-) AGGAT(A/G)TGGTC intron-variant
rs722763 -- 86,982,937(+) GGAGA(A/G)AAGGG intron-variant
rs828358 -- 86,939,735(+) CACAA(A/G)CATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR1E Gene

Variant ID Type Subtype PubMed ID
esv267623 CNV Insertion 20981092
esv2444959 CNV Deletion 19546169

Variation tolerance for HTR1E Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1E Gene

HapMap Linkage Disequilibrium report
HTR1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1E Gene

Disorders for HTR1E Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTR1E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
- elite association
Search HTR1E in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1E

Genetic Association Database (GAD)
HTR1E
Human Genome Epidemiology (HuGE) Navigator
HTR1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1E
genes like me logo Genes that share disorders with HTR1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1E Gene

Publications for HTR1E Gene

  1. Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. (PMID: 17848919) Nasrallah H.A. (Mol. Psychiatry 2008) 25 26
  2. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. (PMID: 14744596) Bai F. … Nelson D.L. (Eur. J. Pharmacol. 2004) 23 67
  5. 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. (PMID: 9316030) Pierce P.A. … Peroutka S.J. (Neuroscience 1997) 23 67

Products for HTR1E Gene

Sources for HTR1E Gene

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