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HTR1E Gene

protein-coding   GIFtS: 64
GCID: GC06P087647

5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1E)
  See HTR1E-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled1 2     S312 3
Serotonin Receptor 1E2 3     5-Hydroxytryptamine (Serotonin) Receptor 1E1
5-HT-1E2 3     5-Hydroxytryptamine Receptor 1E2
5-HT1E2 3     

External Ids:    HGNC: 52911   Entrez Gene: 33542   Ensembl: ENSG000001688307   OMIM: 1821325   UniProtKB: P285663   

Export aliases for HTR1E gene to outside databases

Previous GC identifers: GC06P087593 GC06P087643 GC06P087704 GC06P084863


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HTR1E Gene:
HTR1E (5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1E include skin papilloma. GO annotations related to this gene include serotonin binding and G-protein coupled receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
adenylate cyclase. Signaling inhibits adenylate cyclase activity

summary for HTR1E Gene:
Serotonin 5-ht1E receptors are primarily located in the cortex, caudate putamen, claustrum, hippocampus, and
amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15). The function of this
receptor has yet to be elucidated.

Gene Wiki entry for HTR1E (5-HT1E receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HTR1E
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1E promoter sequence
   Search Chromatin IP Primers for HTR1E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14-q15   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q14-q15

HTR1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P087647:  view genomic region     (about GC identifiers)

Start:
87,647,024 bp from pter      End:
87,726,397 bp from pter
Size:
79,374 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1E  
Size: 365 amino acids; 41682 Da
Secondary accessions: E1P503 Q9P1Y1

Explore the universe of human proteins at neXtProt for HTR1E: NX_P28566

Explore proteomics data for HTR1E at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn2, Asn5

  • See HTR1E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000856.1  
    ENSEMBL proteins: 
     ENSP00000307766  
    Reactome Protein details: P28566

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-ht1e receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR027425 5HT1E_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28566

    ProtoNet protein and cluster: P28566

    1 Blocks protein domain: IPB002231 5-hydroxytryptamine receptor signature

    UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with HTR1E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1E_HUMAN, P28566
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
    guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
    adenylate cyclase. Signaling inhibits adenylate cyclase activity

         Genatlas biochemistry entry for HTR1E:
    5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate
    cyclase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS1733778
    GO:0004993serotonin receptor activity IMP--
    GO:0051378serotonin binding IDA1608964
         
    Find genes that share ontologies with HTR1E           About GenesLikeMe


    Animal Models:
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    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-3927 hsa-let-7b
    SwitchGear 3'UTR luciferase reporter plasmidHTR1E 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT1E_HUMAN, P28566: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HTR1E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR1E About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33


    Find genes that share SuperPaths with HTR1E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR1E
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR1E
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR1E
        Serotonin receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for HTR1E
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HTR1E):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Array including HTR1E: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR1E (P285663 ENSP000003077664) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC3P179803, ENSP000002988524I2D: score=2 STRING: ENSP00000298852
    PSMC4P436863, ENSP000001578124I2D: score=2 STRING: ENSP00000157812
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS1608964
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1733778
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP--
    GO:0007210serotonin receptor signaling pathway IMP--
    GO:0007268synaptic transmission IEA--

    Find genes that share ontologies with HTR1E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for HTR1E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BRL 54443Potent 5-ht1E/F agonist[57477-39-1]

    1 HMDB Compound for HTR1E    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--

    6 DrugBank Compounds for HTR1E    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Eletriptan-- 143322-58-1targetagonist17139284 17016423
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist17848919
    Clozapine-- 5786-21-0targetantagonist17848919
    Olanzapine-- 132539-06-1targetantagonist17848919
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7targetother/unknown17848919
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist17848919

    Selected IUPHAR Ligands for HTR1E (5-ht1e receptor) (see all 46)    About this table
    LigandTypeActionAffinityPubmed IDs
    BRL-54443
    AgonistFull agonist8.7--
    [3H]5-HT
    AgonistFull agonist8.1 - 8.28863519 1608964
    5-HT
    AgonistFull agonist8 - 8.28380639 15110837 14744596 1608964
    asenapine
    AgonistFull agonist88935801
    zolmitriptan
    AgonistFull agonist7.710193663
    naratriptan
    AgonistFull agonist7.710193663
    lysergol
    AgonistFull agonist7.48863519
    ergonovine
    AgonistFull agonist7.314744596
    eletriptan
    AgonistFull agonist7.210193663
    methylergonovine
    AntagonistAntagonist7 - 7.28380639 15110837

    6 Novoseek inferred chemical compound relationships for HTR1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-carboxamidotryptamine 83.8 1 1513320 (1)
    5-hydroxytryptamine 76.5 4 8883928 (1), 1513320 (1)
    methysergide 75.6 1 1513320 (1)
    ergotamine 75 1 1513320 (1)
    guanine 46.8 1 8450834 (1)
    oligonucleotide 29.1 1 9316030 (1)



    Find genes that share compounds with HTR1E           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HTR1E gene: 
    NM_000865.2  

    Unigene Cluster for HTR1E:

    5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
    Hs.1611  [show with all ESTs]
    Unigene Representative Sequence: NM_000865
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305344(uc003pli.3)
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    Additional mRNA sequence: 

    AF498980.1 BC069751.1 M91467.1 

    3 DOTS entries:

    DT.91739998  DT.100670613  DT.100661910 

    Selected AceView cDNA sequences (see all 25):

    CR606192 CR618239 CR596923 BC069751 AF498980 BX349901 NM_000865 AL522462 
    BX389401 AL520435 AL561841 AL521494 AL561877 BX355486 CB565887 M91467 
    AL520002 AL522463 AI807334 AL519220 AL521170 AI479667 AL521493 AL521169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGATGGG
    HTR1E Expression
    About this image

    HTR1E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR1E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1611

    UniProtKB/Swiss-Prot: 5HT1E_HUMAN, P28566
    Tissue specificity: Detected in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including HTR1E: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HTR1E gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HTR1E1 5-hydroxytryptamine (serotonin) receptor 1E 75.73(n)
    86.81(a)
      771973  XM_004940395.1  XP_004940452.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1E6
    5-hydroxytryptamine (serotonin) receptor 1E, G pro...
    82(a)
    1 ↔ 1
    1(176521736-176522830)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221722 Xenopus laevis transcribed sequence with moderate similarity more 72.19(n)    48025952 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003306811 5-hydroxytryptamine receptor 1E-like 65.93(n)
    68.14(a)
      100330681  XM_002665643.2  XP_002665689.1 
            Species with no ortholog for HTR1E

    ENSEMBL Gene Tree for HTR1E (if available)
    TreeFam Gene Tree for HTR1E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR1E gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  
    ADRA1A2  HTR5A2  HTR1B2  ADRA1D2  
    16 SIMAP similar genes for HTR1E using alignment to 1 protein entry:     5HT1E_HUMAN:
    HTR1F    HTR1D    HTR1B    5HT1A    HTR1A    HTR5A
    ADRA1D    HTR7    HTR2C    ADRA1A    HTR2A    ADRA1B
    DRD3    ADRB1    DRD1    HRH2

    Find genes that share paralogs with HTR1E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR1E (see all 1514)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420013311,2
    Cuntested187725851(+) TCCCCA/C/TCCTTC 2 P S mis10--------
    rs716529781,2
    C--84899619(+) GTGGCTGTGTG/-
            
    TGTGT
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1134630671,2
    C,F--87645033(+) AAGTTT/GCCCCA 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1181253731,2
    C,F--87645148(+) TGATGA/TCTTTT 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs1486217051,2
    --87645189(+) CCTTAC/TAGTTT 1 -- us2k10--------
    rs753834571,2
    C,F--87645345(+) TTATTA/GAAACT 1 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1420582151,2
    --87645362(+) ATATAC/TGCCAG 1 -- us2k10--------
    rs1511306071,2
    C--87645430(+) AAAGCA/GGGTAT 1 -- us2k10--------
    rs1916207781,2
    --87645435(+) GGGTAC/TTCTGA 1 -- us2k10--------
    rs1406117691,2
    C--87645490(+) AGTTCC/TTTATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTR1E (87647024 - 87726397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HTR1E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2444959CNV Deletion19546169
    esv267623CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR1E
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR1E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182132    OMIM disorders: --

    1 disease for HTR1E:    
    About MalaCards
    skin papilloma

    1 disease from the University of Copenhagen DISEASES database for HTR1E:
    Skin papilloma

    Find genes that share disorders with HTR1E           About GenesLikeMe

    Genetic Association Database (GAD): HTR1E
    Human Genome Epidemiology (HuGE) Navigator: HTR1E (9 documents)

    Export disorders for HTR1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR1E gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with HTR1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. (PubMed id 1608964)1, 2, 3 McAllister G.... Whiting P. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. (PubMed id 1733778)1, 2, 9 Levy F.O.... Birnbaumer L. (FEBS Lett. 1992)
    3. Human gene S31 encodes the pharmacologically defined serotonin 5- hydroxytryptamine1E receptor. (PubMed id 1513320)1, 2, 9 Zgombick J.M....Weinshank R.L. (Mol. Pharmacol. 1992)
    4. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    8. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. (PubMed id 18937842)1, 4 Oades R.D....Asherson P. (Behav Brain Funct 2008)
    9. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    10. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. (PubMed id 18079067)1, 4 Smith A.K....Rajeevan M.S. (Psychoneuroendocrinology 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3354 HGNC: 5291 AceView: HTR1E Ensembl:ENSG00000168830 euGenes: HUgn3354
    ECgene: HTR1E Kegg: 3354 H-InvDB: HTR1E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR1E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR1E gene:
    Search GeneIP for patents involving HTR1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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