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Aliases for HTR1E Gene

Aliases for HTR1E Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled 2 3
  • Serotonin Receptor 1E 3 4
  • 5-HT-1E 3 4
  • 5-HT1E 3 4
  • S31 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1E 2
  • 5-Hydroxytryptamine Receptor 1E 3

External Ids for HTR1E Gene

Previous GeneCards Identifiers for HTR1E Gene

  • GC06P087593
  • GC06P087643
  • GC06P087704
  • GC06P087647
  • GC06P084863

Summaries for HTR1E Gene

GeneCards Summary for HTR1E Gene

HTR1E (5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1E include skin papilloma. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1E Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Tocris Summary for HTR1E Gene

  • Serotonin 5-ht1E receptors are primarily located in the cortex, caudate putamen, claustrum, hippocampus, and amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15). The function of this receptor has yet to be elucidated.

Gene Wiki entry for HTR1E Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1E Gene

Genomics for HTR1E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTR1E Gene

86,937,306 bp from pter
87,016,683 bp from pter
79,378 bases
Plus strand

Genomic View for HTR1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1E Gene

No data available for Regulatory Elements for HTR1E Gene

Proteins for HTR1E Gene

  • Protein details for HTR1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-hydroxytryptamine receptor 1E
    Protein Accession:
    Secondary Accessions:
    • E1P503
    • Q9P1Y1

    Protein attributes for HTR1E Gene

    365 amino acids
    Molecular mass:
    41682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTR1E Gene

Proteomics data for HTR1E Gene at MOPED

Post-translational modifications for HTR1E Gene

  • Glycosylation at Asn2 and Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR1E Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1E Gene

Domains for HTR1E Gene

Gene Families for HTR1E Gene

  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
  • HTR :5-HT (serotonin) receptors

Protein Domains for HTR1E Gene

Suggested Antigen Peptide Sequences for HTR1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P28566
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1E: view

Function for HTR1E Gene

Molecular function for HTR1E Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype IE,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Gene Ontology (GO) - Molecular Function for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 1733778
GO:0004993 serotonin receptor activity IMP 21422162
GO:0005515 protein binding IPI 25416956
GO:0051378 serotonin binding IDA 1608964
genes like me logo Genes that share ontologies with HTR1E: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTR1E Gene

Localization for HTR1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1E Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HTR1E Gene COMPARTMENTS Subcellular localization image for HTR1E gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 21422162
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1E: view

Pathways for HTR1E Gene

genes like me logo Genes that share pathways with HTR1E: view

Pathways by source for HTR1E Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for HTR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 1608964
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1733778
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 21422162
GO:0007210 serotonin receptor signaling pathway IMP 21422162
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR1E: view

Compounds for HTR1E Gene

(1) Tocris Compounds for HTR1E Gene

Compound Action Cas Number
BRL 54443 Potent 5-ht1E/F agonist [57477-39-1]

(1) HMDB Compounds for HTR1E Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-(2-Aminoethyl)-1H-indol-5-ol

(6) Drugbank Compounds for HTR1E Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • OPC 31
129722-12-9 target antagonist
5786-21-0 target antagonist
143322-58-1 target agonist
132539-06-1 target antagonist
  • Quetiapine fumarate
111974-69-7 target other/unknown

(46) IUPHAR Ligand for HTR1E Gene

Ligand Type Action Affinity Pubmed IDs
asenapine Antagonist Antagonist 9.8
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
[3H]5-HT Agonist Full agonist 9
BRL-54443 Agonist Full agonist 8.9
quetiapine Antagonist Antagonist 8.7
ergotamine Agonist Full agonist 8.6
DOI Agonist Full agonist 8.6
m-CPP Agonist Partial agonist 8.5
rauwolscine Antagonist Antagonist 8.4
methylergonovine Agonist Full agonist 8.3
1-naphthylpiperazine Agonist Full agonist 8
fluspirilene Antagonist Antagonist 7.9
ziprasidone Antagonist Antagonist 7.8
EMDT Agonist Full agonist 7.8
risperidone Antagonist Antagonist 7.8
naratriptan Agonist Full agonist 7.6
9-OH-risperidone Antagonist Antagonist 7.5
lysergol Agonist Full agonist 7.4
eletriptan Agonist Full agonist 7.4
metergoline Antagonist Antagonist 7.4
ergonovine Agonist Full agonist 7.3
yohimbine Antagonist Antagonist 7.3
tryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
5-MeO-DMT Agonist Full agonist 7
sertindole Antagonist Antagonist 6.9
methysergide Antagonist Antagonist 6.8
5-MeOT Agonist Full agonist 6.8
clozapine Antagonist Antagonist 6.7
zolmitriptan Agonist Full agonist 6.6
rizatriptan Agonist Full agonist 6.4
2-methyl-5-HT Agonist Full agonist 6.4
TFMPP Agonist Full agonist 6.4
5-fluorotryptamine Agonist Full agonist 6.3
LY344864 Agonist Full agonist 6.3
5-CT Agonist Full agonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
alpha-methyl-5-HT Agonist Full agonist 5.8
GR-127935 Agonist Partial agonist 5.8
donitriptan Agonist Partial agonist 5.6
sumatriptan Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2

(6) Novoseek inferred chemical compound relationships for HTR1E Gene

Compound -log(P) Hits PubMed IDs
5-carboxamidotryptamine 83.8 1
5-hydroxytryptamine 76.5 2
methysergide 75.6 1
ergotamine 75 1
guanine 46.8 1
genes like me logo Genes that share compounds with HTR1E: view

Transcripts for HTR1E Gene

mRNA/cDNA for HTR1E Gene

(3) REFSEQ mRNAs :
(25) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1E Gene

5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTR1E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1E Gene

No ASD Table

Relevant External Links for HTR1E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTR1E Gene

mRNA expression in normal human tissues for HTR1E Gene

mRNA differential expression in normal tissues according to GTEx for HTR1E Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.6), Brain - Cortex (6.4), Brain - Anterior cingulate cortex (BA24) (5.6), Brain - Nucleus accumbens (basal ganglia) (5.2), and Brain - Caudate (basal ganglia) (4.1).

SOURCE GeneReport for Unigene cluster for HTR1E Gene Hs.1611

mRNA Expression by UniProt/SwissProt for HTR1E Gene

Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with HTR1E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for HTR1E Gene

Orthologs for HTR1E Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTR1E 35
  • 99.54 (n)
  • 100 (a)
HTR1E 36
  • 100 (a)
(Bos Taurus)
Mammalia HTR1E 35
  • 89.13 (n)
  • 95.07 (a)
HTR1E 36
  • 95 (a)
(Canis familiaris)
Mammalia HTR1E 35
  • 90.5 (n)
  • 94.52 (a)
HTR1E 36
  • 95 (a)
(Mus musculus)
Mammalia Htr5b 36
  • 31 (a)
(Monodelphis domestica)
Mammalia HTR1E 36
  • 92 (a)
(Gallus gallus)
Aves HTR1E 35
  • 75.73 (n)
  • 86.81 (a)
HTR1E 36
  • 85 (a)
(Anolis carolinensis)
Reptilia HTR1E 36
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22172 35
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1e 35
  • 71.88 (n)
  • 82.68 (a)
Str.3647 35
(Danio rerio)
Actinopterygii HTR1E 36
  • 64 (a)
LOC100330681 35
  • 65.93 (n)
  • 68.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 43 (a)
5-HT1B 37
  • 42 (a)
5-HT7 37
  • 34 (a)
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 37 (a)
Species with no ortholog for HTR1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1E Gene

Gene Tree for HTR1E (if available)
Gene Tree for HTR1E (if available)

Paralogs for HTR1E Gene

Paralogs for HTR1E Gene

Selected SIMAP similar genes for HTR1E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1E: view

Variants for HTR1E Gene

Sequence variations from dbSNP and Humsavar for HTR1E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6302 -- 87,015,865(+) CAGCA(C/T)GACCA reference, synonymous-codon
rs6303 - 87,016,119(+) TGCCT(C/T)CATCA reference, missense
rs718166 -- 86,983,905(-) AGGAT(A/G)TGGTC intron-variant
rs722763 -- 86,982,937(+) GGAGA(A/G)AAGGG intron-variant
rs828358 -- 86,939,735(+) CACAA(A/G)CATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTR1E Gene

Variant ID Type Subtype PubMed ID
esv267623 CNV Insertion 20981092
esv2444959 CNV Deletion 19546169

Relevant External Links for HTR1E Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1E Gene

Disorders for HTR1E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HTR1E Gene including...

Search for HTR1E Gene in MalaCards »

(1) University of Copenhagen DISEASES for HTR1E Gene

Relevant External Links for HTR1E

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTR1E: view

No data available for UniProtKB/Swiss-Prot for HTR1E Gene

Publications for HTR1E Gene

  1. Human gene S31 encodes the pharmacologically defined serotonin 5- hydroxytryptamine1E receptor. (PMID: 1513320) Zgombick J.M. … Weinshank R.L. (Mol. Pharmacol. 1992) 3 4 23
  2. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. (PMID: 1733778) Levy F.O. … Birnbaumer L. (FEBS Lett. 1992) 3 4 23
  3. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. (PMID: 1608964) McAllister G. … Whiting P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4
  4. 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. (PMID: 9316030) Pierce P.A. … Peroutka S.J. (Neuroscience 1997) 3 23
  5. Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. (PMID: 14744596) Bai F. … Nelson D.L. (Eur. J. Pharmacol. 2004) 4 23

Products for HTR1E Gene

Sources for HTR1E Gene

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