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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR1D Gene

protein-coding   GIFtS: 68
GCID: GC01M023517

5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1D)
(Previous symbol: HTRL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled1 2     5-HT1D2 3
HTRL1 2 3     HTR1DA2 3
Serotonin 1D Alpha Receptor2 3     5-Hydroxytryptamine (Serotonin) Receptor 1D1
Serotonin Receptor 1D2 3     5-Hydroxytryptamine Receptor 1D2
5-HT-1D2 3     HT1DA2
5-HT-1D-alpha2 3     RDC42

External Ids:    HGNC: 52891   Entrez Gene: 33522   Ensembl: ENSG000001795467   OMIM: 1821335   UniProtKB: P282213   

Export aliases for HTR1D gene to outside databases

Previous GC identifers: GC01M023088 GC01M022554 GC01M022664 GC01M022987 GC01M023263 GC01M023389 GC01M021762


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HTR1D Gene: 
HTR1D (5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1D include cluster headache, and borderline personality disorder, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include serotonin binding and serotonin receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins that inhibit adenylate cyclase activity

summary for HTR1D Gene:
Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal
ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to
be involved in anxiety, depression, and other neuropsychiatric disorders. The human 5-HT1D receptor gene has
been localized to chromosome 1 (1p34.3-36.3).

Gene Wiki entry for HTR1D (5-HT1D receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR1D gene promoter:
         GATA-3   CUTL1   HNF-3beta   GATA-1   GATA-2   SRY   STAT3   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1D promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3-p34.3   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.3-p34.3

HTR1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1D gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023517:  view genomic region     (about GC identifiers)

Start:
23,516,993 bp from pter      End:
23,521,222 bp from pter
Size:
4,230 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1D  
Size: 377 amino acids; 41907 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for HTR1D: NX_P28221

Explore proteomics data for HTR1D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P28221

  • HTR1D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTR1D Protein Expression
    REFSEQ proteins: NP_000855.1  
    ENSEMBL proteins: 
     ENSP00000363748   ENSP00000313661  
    Reactome Protein details: P28221
    Human Recombinant Protein Products for HTR1D: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals HTR1D Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR1D 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA1652050
    GO:0016021integral to membrane ----

    HTR1D for ontologies           About GeneDecksing



    HTR1D Antibody Products: 
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    Assay Products for HTR1D: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTR1D 
    Cloud-Clone Corp. CLIAs for HTR1D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1D receptor 
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR000505 5HT1D_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28221

    ProtoNet protein and cluster: P28221

    2 Blocks protein domains:
    IPB000505 5-hydroxytryptamine 1D receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR1D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1D_HUMAN, P28221
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins that inhibit adenylate cyclase activity

         Genatlas biochemistry entry for HTR1D:
    5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor
    superfamily,inhibiting adenylate cyclase

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IMP1652050
    GO:0051378serotonin binding IEA--
         
    HTR1D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR1D:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Htr1d):
     normal 

    HTR1D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr1dtm1Lex for HTR1D

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HTR1D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTR1D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR1D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR1D 

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR1D (see all 10):
    hsa-miR-379 hsa-miR-100* hsa-miR-3140-3p hsa-miR-18a hsa-miR-888 hsa-miR-3927 hsa-miR-130b* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHTR1D 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for HTR1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTR1D

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HTR1D

    Clone
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    GenScript: all cDNA clones in your preferred vector: HTR1D (NM_000864)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1D
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    Sirion Biotech Customized lentivirus for stable overexpression of HTR1D 
                         Customized lentivirus expression plasmids for stable overexpression of HTR1D 

    Cell Line
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    Search LifeMap BioReagents cell lines for HTR1D
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HTR1D About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.36
    Amine ligand-binding receptors0.79
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics0.33
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1D
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR1D
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/8        Reactome Pathways for HTR1D (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    Serotonin receptors

    1 PharmGKB Pathway for HTR1D
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for HTR1D):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR1D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTR1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for HTR1D (P282213 ENSP000003136614) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR1AP089083, ENSP000003162444I2D: score=3 STRING: ENSP00000316244
    HTR1BP282223, ENSP000003589634I2D: score=3 STRING: ENSP00000358963
    S1PR1P214533, ENSP000003054164I2D: score=3 STRING: ENSP00000305416
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1565658
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP1652050
    GO:0007210serotonin receptor signaling pathway ----
    GO:0007268synaptic transmission IEA--

    HTR1D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR1D for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HTR1D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 310762 hydrochloride5-HT1D-preferring antagonist[192927-92-7]
    PNU 142633Highly selective 5-HT1D agonist[187665-65-2]
    L-694,247 5-HT1D agonist[137403-12-4]
    PNU 109291Potent and selective 5-HT1D agonist[187665-60-7]
    GR 127935 hydrochloride Potent, selective 5-HT1B/1D antagonist [148672-13-3]

    2 HMDB Compounds for HTR1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    SumatriptanImigran (see all 4)103628-46-2--

    10/24 DrugBank Compounds for HTR1D (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Naratriptan-- 121679-13-8targetagonist12010764 8741180 12463278 11897116 10410185 14728705 14725972 11152011 11752352 16389295 20687618 10563228
    Frovatriptan-- 158747-02-5targetagonist9700983 11735616 15342617 15185063 10883409 11152011 12028320 11752352 12028322 18360605 15311727
    SumatriptanNP101 (see all 4)103628-46-2targetagonist12110114 11641558 18723285 10772044 15554784 10454495 12010765 11874390 11752352 10225363 11313163
    Zolmitriptan-- 139264-17-8targetagonist11513839 11594437 10463324 20407761 10844127 9399012 15096229 11752352 9859690 10563228
    RizatriptanMK 462 Free Base (see all 4)145202-66-0targetagonist12269863 9127118 11487512 12093318 15056946 8904614 11752352 9056052 15821444
    Dihydroergotamine9,10-dihydro-ergotamine (see all 6)6190-39-2targetagonist1407010 1324091 12558771 9605573 11752352 14744615 1379707
    Eletriptan-- 143322-58-1targetagonist11513839 12498013 11152011 10193663 11752352 15821444
    Ergotamine-- 113-15-5targetagonist1407010 12558771 14504136 8384716 1646776
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11910268 10516958 7562537 11132243
    Almotriptan-- 181183-52-8targetagonist11134654 11642004 11752352 10193663

    10/82 IUPHAR Ligands for HTR1D (5-HT1D receptor) (see all 82)    About this table 
    LigandTypeActionAffinityPubmed IDs
    5-HT-moduline
    Allosteric regulatorNegative129774213
    dihydroergotamine
    AgonistFull agonist9.2 - 9.91652050 9605573 8967979
    alniditan
    AgonistFull agonist8.7 - 9.48967979 9605573
    oxymetazoline
    AgonistPartial agonist9.49632357
    zotepine
    AntagonistAntagonist9.38935801
    donitriptan
    AgonistFull agonist9.310381763
    metergoline
    AntagonistAntagonist8.6 - 9.21652050 9303569 8967979
    lysergol
    AgonistFull agonist9.21565658
    7-methoxy-1-naphthylpiperazine
    AgonistFull agonist9.29397179
    5-CT
    AgonistFull agonist8.6 - 9.21565658 1652050 8967979

    10/34 Novoseek inferred chemical compound relationships for HTR1D gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sumatriptan 90.6 14 1326402 (2), 8164519 (1), 8384716 (1), 7516861 (1) (see all 13)
    ly 344864 89.2 3 12434581 (1), 10711348 (1), 15320857 (1)
    gr 127935 87.4 4 8938651 (1), 8741180 (1), 9278519 (1)
    5-carboxamidotryptamine 87.1 4 8164519 (1), 14965240 (1), 8384716 (1)
    methiothepin 83.4 3 2043924 (1), 8978753 (1), 8903941 (1)
    naratriptan 83.4 3 8741180 (2), 10193663 (1)
    zolmitriptan 83 4 9154322 (1), 9071266 (1), 10193663 (1), 9350394 (1)
    metergoline 82 2 8938651 (1), 2043924 (1)
    5-hydroxytryptamine 78.8 12 2043924 (2), 9335552 (1), 9016944 (1), 8232238 (1) (see all 10)
    rizatriptan 77.9 1 10193663 (1)

    Search CenterWatch for drugs/clinical trials and news about HTR1D / 5HT1D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTR1D gene: 
    NM_000864.4  

    Unigene Cluster for HTR1D:

    5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
    Hs.121482  [show with all ESTs]
    Unigene Representative Sequence: NM_000864
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374619(uc001bgn.3) ENST00000314113
    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR1D (see all 10):
    hsa-miR-379 hsa-miR-100* hsa-miR-3140-3p hsa-miR-18a hsa-miR-888 hsa-miR-3927 hsa-miR-130b* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHTR1D 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene clones in human, mouse for HTR1D (see all 7)
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    GenScript: all cDNA clones in your preferred vector: HTR1D (NM_000864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1D
    Sirion Biotech Customized lentivirus for stable overexpression of HTR1D 
                         Customized lentivirus expression plasmids for stable overexpression of HTR1D 
    Primer
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    OriGene qPCR primer pairs and template standards for HTR1D
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR1D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR1D

    Additional mRNA sequence: 

    AF498979.1 BC007720.2 BT007027.1 M81589.1 

    1 DOTS entry:

    DT.75136214 

    10 AceView cDNA sequences:

    AF498979 NM_000864 BT007027 BC007720 AA132509 BF196846 BX281878 M81589 
    BF688599 AW051032 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR1D expression in normal human tissues (normalized intensities)      HTR1D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAAAAAA
    HTR1D Expression
    About this image


    HTR1D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See HTR1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR1D

    SOURCE GeneReport for Unigene cluster: Hs.121482
        SABiosciences Expression via Pathway-Focused PCR Arrays including HTR1D: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HTR1D gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1d1 , 5 5-hydroxytryptamine (serotonin) receptor 1D1, 5 85.38(n)1
    90.91(a)1
      4 (68.74 cM)5
    155521  NM_008309.41  NP_032335.21 
     1364235245 
    chicken
    (Gallus gallus)
    Aves HTR1D1 5-hydroxytryptamine (serotonin) receptor 1D 71.62(n)
    79.84(a)
      769107  XM_003642559.1  XP_003642607.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1D6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    AAWZ02038557(5595-6725)
    zebrafish
    (Danio rerio)
    Actinopterygii htr1bd1 5-hydroxytryptamine (serotonin) receptor 1bd 70.33(n)
    72.68(a)
      556429  NM_001145686.1  NP_001139158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23
    5-HT1B1
    dopamine receptor signaling pathway
    dopamine receptor3
    Serotonin receptor 1B1
    45(a)
    (best of 5)3
    55.77(n)1
    45.28(a)1
      3 99B53
    371911  NM_001169730.21  NP_001163201.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33 G-protein coupled receptor 37(a)   X(4985611-4990413)   --


    ENSEMBL Gene Tree for HTR1D (if available)
    TreeFam Gene Tree for HTR1D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR1D gene
    HTR2A2  DRD42  HTR1A2  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  
    HTR2C2  ADRA2A2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18/21 SIMAP similar genes for HTR1D using alignment to 1 protein entry:     5HT1D_HUMAN(see all similar genes):
    HTR1B    HTR1F    HTR1E    5HT1A    HTR1A    HTR5A
    DRD1    HTR7    ADRA1D    ADRB1    ADRB2    ADRA1A
    HTR2A    HTR2B    DRD3    ADRA1B    HTR2C    ADRA2C

    HTR1D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HTR1D
    PGOHUM00000239288


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/151 SNPs in HTR1D are shown (see all 151)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889422201,2
    C--23518081(+) TTTGTA/GTTTTT 1 -- int10--------
    rs66675371,2
    C--23518147(+) aagcaA/Gtcctc 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1404259611,2
    C--23518153(+) TCCTCA/CCACCT 1 -- int10--------
    rs6040301,2
    C,F,O,A,H--23518227(+) CATCAT/CGCTAT 1 -- int119Minor allele frequency- C:0.34NS EA NA WA 1324
    rs1816315701,2
    C--23518289(+) TGGGAA/CCTGGC 1 -- int10--------
    rs1872039161,2
    --23518440(+) AATGAA/GTTTTC 1 -- ut310--------
    rs32159061,2
    C,F--23518471(-) TTTTT-/TAACAT 1 -- ut316Minor allele frequency- T:0.00MN CSA 398
    rs6053671,2
    C,F,A--23518524(+) TGCGGT/CGGGTG 1 -- ut31 ese318Minor allele frequency- C:0.39EA NA MN WA CSA 889
    rs1903733881,2
    --23518717(+) ATCATC/TGGCAC 1 -- ut310--------
    rs1825754601,2
    --23518746(+) CTTCAC/TGGACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HTR1D (23516993 - 23521222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR1D:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834424CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182133    OMIM disorders: --

    19 diseases for HTR1D:    About MalaCards
    cluster headache    borderline personality disorder    headache    migraine with aura
    personality disorder    migraine    obsessive-compulsive disorder    eating disorder
    was-related disorders    attention deficit hyperactivity disorder    anorexia nervosa    myoclonus
    schizophrenia    bipolar disorder    astrocytoma    alcoholism
    cerebritis    lung cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HTR1D:
    Migraine

    HTR1D for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HTR1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 67.3 12 9949863 (3), 1871321 (1), 1326402 (1), 7658443 (1) (see all 10)
    schizophrenia 14.7 1 8104876 (1)
    genetic susceptibility 1.85 1 17572793 (1)
    inflammation 0 2 9071266 (1), 9243618 (1)

    Genetic Association Database (GAD): HTR1D
    Human Genome Epidemiology (HuGE) Navigator: HTR1D (26 documents)

    Export disorders for HTR1D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR1D gene, integrated from 9 sources (see all 219):
    (articles sorted by number of sources associating them with HTR1D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. (PubMed id 17099886)1, 4, 9 Li J....Faraone S.V. (2006)
    2. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. (PubMed id 1565658)1, 2, 9 Weinshank R.L....Hartig P.R. (1992)
    3. Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (2010)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    5. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    6. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    7. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (2010)
    8. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    9. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    10. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3352 HGNC: 5289 AceView: HTR1D Ensembl:ENSG00000179546 euGenes: HUgn3352
    ECgene: HTR1D Kegg: 3352 H-InvDB: HTR1D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR1D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HTR1D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTR1D gene:
    Search GeneIP for patents involving HTR1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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