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HTR1D Gene

protein-coding   GIFtS: 68
GCID: GC01M023517

5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1D)
(Previous symbol: HTRL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled1 2     5-HT1D2 3
HTRL1 2 3     HTR1DA2 3
Serotonin 1D Alpha Receptor2 3     5-Hydroxytryptamine (Serotonin) Receptor 1D1
Serotonin Receptor 1D2 3     5-Hydroxytryptamine Receptor 1D2
5-HT-1D2 3     HT1DA2
5-HT-1D-alpha2 3     RDC42

External Ids:    HGNC: 52891   Entrez Gene: 33522   Ensembl: ENSG000001795467   OMIM: 1821335   UniProtKB: P282213   

Export aliases for HTR1D gene to outside databases

Previous GC identifers: GC01M023088 GC01M022554 GC01M022664 GC01M022987 GC01M023263 GC01M023389 GC01M021762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HTR1D Gene:
HTR1D (5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1D include headache, and borderline personality disorder. GO annotations related to this gene include serotonin binding and serotonin receptor activity. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot
alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand
binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins)
and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate
cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity.
May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction

summary for HTR1D Gene:
Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal
ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to
be involved in anxiety, depression, and other neuropsychiatric disorders. The human 5-HT1D receptor gene has
been localized to chromosome 1 (1p34.3-36.3).

Gene Wiki entry for HTR1D (5-HT1D receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR1D gene promoter:
         GATA-3   CUTL1   HNF-3beta   GATA-1   GATA-2   SRY   STAT3   FOXO1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1D promoter sequence
   Search Chromatin IP Primers for HTR1D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3-p34.3   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.3-p34.3

HTR1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1D gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023517:  view genomic region     (about GC identifiers)

Start:
23,516,993 bp from pter      End:
23,521,222 bp from pter
Size:
4,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1D  
Size: 377 amino acids; 41907 Da
Subunit: Homodimer. Heterodimer with HTR1B

Explore the universe of human proteins at neXtProt for HTR1D: NX_P28221

Explore proteomics data for HTR1D at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn17, Asn21

  • See HTR1D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000855.1  
    ENSEMBL proteins: 
     ENSP00000363748   ENSP00000313661  
    Reactome Protein details: P28221

    HTR1D Human Recombinant Protein Products:

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    HTR1D Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HTR1D
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    Cloud-Clone Corp. ELISAs for HTR1D
    Cloud-Clone Corp. CLIAs for HTR1D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1D receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR000505 5HT1D_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28221

    ProtoNet protein and cluster: P28221

    2 Blocks protein domains:
    IPB000505 5-hydroxytryptamine 1D receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR1D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1D_HUMAN, P28221
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot
    alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand
    binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins)
    and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate
    cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity.
    May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction

         Genatlas biochemistry entry for HTR1D:
    5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor
    superfamily,inhibiting adenylate cyclase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IMP1652050
    GO:0051378serotonin binding IEA--
         
    HTR1D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR1D:
     Increased S DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Htr1d):
     normal 

    HTR1D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htr1dtm1Lex for HTR1D

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR1D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR1D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR1D

    miRNA
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    miRTarBase miRNAs that target HTR1D:
    hsa-mir-196b-5p (MIRT042672), hsa-mir-335-5p (MIRT019223)

    Block miRNA regulation of human, mouse, rat HTR1D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTR1D (see all 10):
    hsa-miR-379 hsa-miR-100* hsa-miR-3140-3p hsa-miR-18a hsa-miR-888 hsa-miR-3927 hsa-miR-130b* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHTR1D 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HTR1D

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HTR1D (NM_000864)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT1D_HUMAN, P28221: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA1652050
    GO:0016021integral component of membrane ----

    HTR1D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR1D About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR1D
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR1D
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR1D
        Serotonin receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for HTR1D
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HTR1D):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR1D for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1D: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HTR1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR1D (P282213 ENSP000003136614) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTR1AP089083, ENSP000003162444I2D: score=3 STRING: ENSP00000316244
    HTR1BP282223, ENSP000003589634I2D: score=3 STRING: ENSP00000358963
    S1PR1P214533, ENSP000003054164I2D: score=3 STRING: ENSP00000305416
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1565658
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP1652050
    GO:0007210serotonin receptor signaling pathway ----
    GO:0007268synaptic transmission IEA--

    HTR1D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HTR1D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LY 310762 hydrochloride5-HT1D-preferring antagonist[192927-92-7]
    PNU 142633Highly selective 5-HT1D agonist[187665-65-2]
    L-694,247 5-HT1D agonist[137403-12-4]
    PNU 109291Potent and selective 5-HT1D agonist[187665-60-7]
    GR 127935 hydrochloride Potent, selective 5-HT1B/1D antagonist [148672-13-3]

    2 HMDB Compounds for HTR1D    About this table
    CompoundSynonyms CAS #PubMed Ids
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    SumatriptanImigran (see all 4)103628-46-2--

    Selected DrugBank Compounds for HTR1D (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Naratriptan-- 121679-13-8targetagonist12010764 8741180 12463278 11897116 10410185 14728705 14725972 11152011 11752352 16389295 20687618 10563228
    Frovatriptan-- 158747-02-5targetagonist9700983 11735616 15342617 15185063 10883409 11152011 12028320 11752352 12028322 18360605 15311727
    SumatriptanNP101 (see all 4)103628-46-2targetagonist12110114 11641558 18723285 10772044 15554784 10454495 12010765 11874390 11752352 10225363 11313163
    Zolmitriptan-- 139264-17-8targetagonist11513839 11594437 10463324 20407761 10844127 9399012 15096229 11752352 9859690 10563228
    RizatriptanMK 462 Free Base (see all 4)145202-66-0targetagonist12269863 9127118 11487512 12093318 15056946 8904614 11752352 9056052 15821444
    Dihydroergotamine9,10-dihydro-ergotamine (see all 6)6190-39-2targetagonist1407010 1324091 12558771 9605573 11752352 14744615 1379707
    Eletriptan-- 143322-58-1targetagonist11513839 12498013 11152011 10193663 11752352 15821444
    Ergotamine-- 113-15-5targetagonist1407010 12558771 14504136 8384716 1646776
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11910268 10516958 7562537 11132243
    Almotriptan-- 181183-52-8targetagonist11134654 11642004 11752352 10193663

    Selected IUPHAR Ligands for HTR1D (5-HT1D receptor) (see all 82)    About this table
    LigandTypeActionAffinityPubmed IDs
    5-HT-moduline
    Allosteric regulatorNegative129774213
    dihydroergotamine
    AgonistFull agonist9.2 - 9.91652050 9605573 8967979
    alniditan
    AgonistFull agonist8.7 - 9.48967979 9605573
    oxymetazoline
    AgonistPartial agonist9.49632357
    zotepine
    AntagonistAntagonist9.38935801
    donitriptan
    AgonistFull agonist9.310381763
    metergoline
    AntagonistAntagonist8.6 - 9.21652050 9303569 8967979
    lysergol
    AgonistFull agonist9.21565658
    7-methoxy-1-naphthylpiperazine
    AgonistFull agonist9.29397179
    5-CT
    AgonistFull agonist8.6 - 9.21565658 1652050 8967979

    Selected Novoseek inferred chemical compound relationships for HTR1D gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sumatriptan 90.6 14 1326402 (2), 8164519 (1), 8384716 (1), 7516861 (1) (see all 13)
    ly 344864 89.2 3 12434581 (1), 10711348 (1), 15320857 (1)
    gr 127935 87.4 4 8938651 (1), 8741180 (1), 9278519 (1)
    5-carboxamidotryptamine 87.1 4 8164519 (1), 14965240 (1), 8384716 (1)
    methiothepin 83.4 3 2043924 (1), 8978753 (1), 8903941 (1)
    naratriptan 83.4 3 8741180 (2), 10193663 (1)
    zolmitriptan 83 4 9154322 (1), 9071266 (1), 10193663 (1), 9350394 (1)
    metergoline 82 2 8938651 (1), 2043924 (1)
    5-hydroxytryptamine 78.8 12 2043924 (2), 9335552 (1), 9016944 (1), 8232238 (1) (see all 10)
    rizatriptan 77.9 1 10193663 (1)



    HTR1D for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR1D gene: 
    NM_000864.4  

    Unigene Cluster for HTR1D:

    5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
    Hs.121482  [show with all ESTs]
    Unigene Representative Sequence: NM_000864
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374619(uc001bgn.3) ENST00000314113
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HTR1D (see all 10):
    hsa-miR-379 hsa-miR-100* hsa-miR-3140-3p hsa-miR-18a hsa-miR-888 hsa-miR-3927 hsa-miR-130b* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidHTR1D 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HTR1D
    Predesigned siRNA for gene silencing in human, mouse, rat HTR1D
    Clone
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    OriGene clones in human, mouse for HTR1D (see all 6)
    OriGene ORF clones in mouse, rat for HTR1D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTR1D (NM_000864)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1D
    Primer
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    OriGene qPCR primer pairs and template standards for HTR1D
    OriGene qSTAR qPCR primer pairs in human, mouse for HTR1D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTR1D
      QuantiTect SYBR Green Assays in human, mouse, rat HTR1D
      QuantiFast Probe-based Assays in human, mouse, rat HTR1D

    Additional mRNA sequence: 

    AF498979.1 BC007720.2 BT007027.1 M81589.1 

    1 DOTS entry:

    DT.75136214 

    10 AceView cDNA sequences:

    BT007027 BC007720 AF498979 NM_000864 BX281878 M81589 BF196846 AA132509 
    BF688599 AW051032 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HTR1D expression in normal human tissues (normalized intensities)      HTR1D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAAAAAA
    HTR1D Expression
    About this image


    HTR1D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Cerebral Cortex
             Septum   
     
     Placenta (Extraembryonic Tissues)
    HTR1D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR1D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121482

    UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221
    Tissue specificity: Detected in brain neocortex and caudate nucleus (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR1D gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1d1 , 5 5-hydroxytryptamine (serotonin) receptor 1D1, 5 85.38(n)1
    90.91(a)1
      4 (68.74 cM)5
    155521  NM_001285483.11  NP_001272412.11 
     1364235245 
    chicken
    (Gallus gallus)
    Aves HTR1D1 5-hydroxytryptamine (serotonin) receptor 1D 71.62(n)
    79.84(a)
      769107  XM_003642559.2  XP_003642607.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1D6
    5-hydroxytryptamine (serotonin) receptor 1D, G pro...
    78(a)
    1 ↔ 1
    AAWZ02038557(5595-6725)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia htr1d1 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 67.24(n)
    77.01(a)
      100494760  XM_002938835.2  XP_002938881.2 
    zebrafish
    (Danio rerio)
    Actinopterygii htr1bd1 5-hydroxytryptamine (serotonin) receptor 1bd 69.3(n)
    71.27(a)
      556429  NM_001145686.1  NP_001139158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DopR23
    Oct-TyrR1
    dopamine receptor signaling pathway
    dopamine receptor3
    Octopamine-Tyramine receptor1
    45(a)
    (best of 5)3
    56.58(n)1
    45.39(a)1
      3 99B53
    424521  NM_079695.41  NP_524419.21 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.33
    tyra-31
    G-protein coupled receptor3
    tyra-31
    37(a)3
    47.07(n)1
    41.55(a)1
      X(4985611-4990413)3
    1874271  NM_001029634.11  NP_001024805.11 


    ENSEMBL Gene Tree for HTR1D (if available)
    TreeFam Gene Tree for HTR1D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR1D gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for HTR1D using alignment to 1 protein entry:     5HT1D_HUMAN(see all similar genes):
    HTR1B    HTR1F    HTR1E    5HT1A    HTR1A    HTR5A
    DRD1    HTR7    ADRA1D    ADRB1    ADRB2    ADRA1A
    HTR2A    HTR2B    DRD3    ADRA1B    HTR2C    ADRA2C

    HTR1D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HTR1D
    PGOHUM00000239288


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR1D (see all 151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889422201,2
    C--23518081(+) TTTGTA/GTTTTT 1 -- int10--------
    rs66675371,2
    C--23518147(+) aagcaA/Gtcctc 1 -- int12Minor allele frequency- G:0.25NA 4
    rs1404259611,2
    C--23518153(+) TCCTCA/CCACCT 1 -- int10--------
    rs6040301,2
    C,F,O,A,H--23518227(+) CATCAT/CGCTAT 1 -- int119Minor allele frequency- C:0.34NS EA NA WA 1324
    rs1816315701,2
    C--23518289(+) TGGGAA/CCTGGC 1 -- int10--------
    rs1872039161,2
    --23518440(+) AATGAA/GTTTTC 1 -- ut310--------
    rs32159061,2
    C,F--23518471(-) TTTTT-/TAACAT 1 -- ut316Minor allele frequency- T:0.00MN CSA 398
    rs6053671,2
    C,F,A--23518524(+) TGCGGT/CGGGTG 1 -- ut31 ese318Minor allele frequency- C:0.39EA NA MN WA CSA 889
    rs1903733881,2
    --23518717(+) ATCATC/TGGCAC 1 -- ut310--------
    rs1825754601,2
    --23518746(+) CTTCAC/TGGACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HTR1D (23516993 - 23521222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR1D:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834424CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR1D
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182133    OMIM disorders: --

    Selected diseases for HTR1D (see all 21):    About MalaCards
    headache    borderline personality disorder    cluster headache    migraine with aura
    personality disorder    migraine    obsessive-compulsive disorder    eating disorder
    attention deficit hyperactivity disorder    anorexia nervosa    myoclonus    was-related disorders
    lung cancer susceptibility    schizophrenia    bipolar disorder    major depressive disorder
    astrocytoma    cerebritis    lung cancer    malaria

    1 disease from the University of Copenhagen DISEASES database for HTR1D:
    Migraine

    HTR1D for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HTR1D gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 67.3 12 9949863 (3), 1871321 (1), 1326402 (1), 7658443 (1) (see all 10)
    schizophrenia 14.7 1 8104876 (1)
    genetic susceptibility 1.85 1 17572793 (1)
    inflammation 0 2 9071266 (1), 9243618 (1)

    Genetic Association Database (GAD): HTR1D
    Human Genome Epidemiology (HuGE) Navigator: HTR1D (26 documents)

    Export disorders for HTR1D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR1D gene, integrated from 10 sources (see all 223):
    (articles sorted by number of sources associating them with HTR1D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. (PubMed id 17099886)1, 4, 9 Li J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    2. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. (PubMed id 1565658)1, 2, 9 Weinshank R.L....Hartig P.R. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. Association study of the serotoninergic system in migraine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    7. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    8. Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. (PubMed id 19032968)1, 4 Ni X....Kennedy J.L. (amp 2009)
    9. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3352 HGNC: 5289 AceView: HTR1D Ensembl:ENSG00000179546 euGenes: HUgn3352
    ECgene: HTR1D Kegg: 3352 H-InvDB: HTR1D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR1D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HTR1D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR1D gene:
    Search GeneIP for patents involving HTR1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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