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Aliases for HTR1D Gene

Aliases for HTR1D Gene

  • 5-Hydroxytryptamine Receptor 1D 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled 2 3 5
  • Serotonin 1D Alpha Receptor 3 4
  • Serotonin Receptor 1D 3 4
  • 5-HT-1D-Alpha 3 4
  • 5-HT-1D 3 4
  • 5-HT1D 3 4
  • HTR1DA 3 4
  • HTRL 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1D 2
  • HT1DA 3
  • RDC4 3

External Ids for HTR1D Gene

Previous HGNC Symbols for HTR1D Gene

  • HTRL

Previous GeneCards Identifiers for HTR1D Gene

  • GC01M023088
  • GC01M022554
  • GC01M022664
  • GC01M022987
  • GC01M023263
  • GC01M023389
  • GC01M023517
  • GC01M021762

Summaries for HTR1D Gene

GeneCards Summary for HTR1D Gene

HTR1D (5-Hydroxytryptamine Receptor 1D) is a Protein Coding gene. Diseases associated with HTR1D include Migraine With Or Without Aura 1 and Obsessive-Compulsive Disorder. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1D Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Tocris Summary for HTR1D Gene

  • Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in neuropsychiatric disorders such as depression.

Gene Wiki entry for HTR1D Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1D Gene

Genomics for HTR1D Gene

Regulatory Elements for HTR1D Gene

Enhancers for HTR1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTR1D on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR1D Gene

Chromosome:
1
Start:
23,191,895 bp from pter
End:
23,194,729 bp from pter
Size:
2,835 bases
Orientation:
Minus strand

Genomic View for HTR1D Gene

Genes around HTR1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1D Gene

Proteins for HTR1D Gene

  • Protein details for HTR1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28221-5HT1D_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1D
    Protein Accession:
    P28221

    Protein attributes for HTR1D Gene

    Size:
    377 amino acids
    Molecular mass:
    41907 Da
    Quaternary structure:
    • Homodimer. Heterodimer with HTR1B.

neXtProt entry for HTR1D Gene

Proteomics data for HTR1D Gene at MOPED

Post-translational modifications for HTR1D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTR1D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1D Gene

Domains & Families for HTR1D Gene

Suggested Antigen Peptide Sequences for HTR1D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28221

UniProtKB/Swiss-Prot:

5HT1D_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1D: view

Function for HTR1D Gene

Molecular function for HTR1D Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
genes like me logo Genes that share phenotypes with HTR1D: view

Animal Models for HTR1D Gene

MGI Knock Outs for HTR1D:

Animal Model Products

  • Taconic Biosciences Mouse Models for HTR1D

miRNA for HTR1D Gene

miRTarBase miRNAs that target HTR1D

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR1D Gene

Localization for HTR1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1D Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1D Gene COMPARTMENTS Subcellular localization image for HTR1D gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for HTR1D Gene

Pathways & Interactions for HTR1D Gene

genes like me logo Genes that share pathways with HTR1D: view

Interacting Proteins for HTR1D Gene

Selected Interacting proteins: P28221-5HT1D_HUMAN for HTR1D Gene via I2D

Gene Ontology (GO) - Biological Process for HTR1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IMP 1652050
GO:0014827 intestine smooth muscle contraction IMP 9186750
GO:0040012 regulation of locomotion IEA --
GO:0050795 regulation of behavior IEA --
genes like me logo Genes that share ontologies with HTR1D: view

No data available for SIGNOR curated interactions for HTR1D Gene

Drugs & Compounds for HTR1D Gene

(108) Drugs for HTR1D Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aripiprazole Approved, Investigational Pharma Antagonist, agonist, Target, antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 343
Dihydroergotamine Approved Pharma Full agonist, Agonist, agonist, Target 10
Naratriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 14
Rizatriptan Approved Pharma Full agonist, Agonist, agonist, Target 35
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 97

(14) Additional Compounds for HTR1D Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+)-lysergic acid
Full agonist, Agonist
<i>m</i>-CPP
Antagonist
5-HT
Full agonist, Agonist
alpha-methyl-5-HT
Full agonist, Agonist
N-Desmethyleletriptan

(5) Tocris Compounds for HTR1D Gene

Compound Action Cas Number
GR 46611 5-HT1D agonist 185259-85-2
L-694,247 5-HT1D agonist 137403-12-4
L-703,664 succinate Selective 5-HT1D receptor agonist 144776-01-2
PNU 109291 Potent and selective 5-HT1D agonist 187665-60-7
PNU 142633 Highly selective 5-HT1D agonist 187665-65-2

(3) ApexBio Compounds for HTR1D Gene

Compound Action Cas Number
Almotriptan Malate 5-HT1B/1D-receptor agonist 181183-52-8
BRL-15572 5-HT1D receptor antagonist 193611-72-2
Eletriptan HBr 177834-92-3
genes like me logo Genes that share compounds with HTR1D: view

Transcripts for HTR1D Gene

mRNA/cDNA for HTR1D Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1D Gene

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1D Gene

No ASD Table

Relevant External Links for HTR1D Gene

GeneLoc Exon Structure for
HTR1D
ECgene alternative splicing isoforms for
HTR1D

Expression for HTR1D Gene

mRNA expression in normal human tissues for HTR1D Gene

mRNA differential expression in normal tissues according to GTEx for HTR1D Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x15.1), Brain - Putamen (basal ganglia) (x9.9), Brain - Caudate (basal ganglia) (x8.2), and Small Intestine - Terminal Ileum (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTR1D Gene



SOURCE GeneReport for Unigene cluster for HTR1D Gene Hs.121482

mRNA Expression by UniProt/SwissProt for HTR1D Gene

P28221-5HT1D_HUMAN
Tissue specificity: Detected in brain neocortex and caudate nucleus (at protein level).
genes like me logo Genes that share expression patterns with HTR1D: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for HTR1D Gene

Orthologs for HTR1D Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1D 35
  • 88.33 (n)
  • 90.45 (a)
HTR1D 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1D 35
  • 87.18 (n)
  • 88.06 (a)
HTR1D 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1d 35
  • 85.38 (n)
  • 90.91 (a)
Htr1d 16
Htr1d 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1D 35
  • 99.38 (n)
  • 99.47 (a)
HTR1D 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1d 35
  • 85.65 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR1D 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1D 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1D 35
  • 71.62 (n)
  • 79.84 (a)
HTR1D 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1D 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1d 35
  • 67.24 (n)
  • 77.01 (a)
zebrafish
(Danio rerio)
Actinopterygii htr1bd 35
  • 69.3 (n)
  • 71.27 (a)
htr1bd 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 41 (a)
5-HT1B 37
  • 37 (a)
5-HT7 37
  • 37 (a)
CG7431 37
  • 38 (a)
DopR2 37
  • 45 (a)
Oct-TyrR 35
  • 56.58 (n)
  • 45.39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRTYR 35
  • 56.04 (n)
  • 44.93 (a)
worm
(Caenorhabditis elegans)
Secernentea M03F4.3 37
  • 37 (a)
tyra-3 35
  • 47.07 (n)
  • 41.55 (a)
Species with no ortholog for HTR1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1D Gene

ENSEMBL:
Gene Tree for HTR1D (if available)
TreeFam:
Gene Tree for HTR1D (if available)

Paralogs for HTR1D Gene

(21) SIMAP similar genes for HTR1D Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HTR1D Gene

genes like me logo Genes that share paralogs with HTR1D: view

Variants for HTR1D Gene

Sequence variations from dbSNP and Humsavar for HTR1D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6299 - 23,193,426(-) GCACT(C/T)GCACT reference, missense
rs6300 -- 23,193,140(-) TTTAA(C/T)GAAGA reference, synonymous-codon
rs636940 -- 23,196,474(+) AGCTA(A/T)ACCTG upstream-variant-2KB
rs604030 -- 23,191,734(+) CATCA(C/T)GCTAT downstream-variant-500B
rs605367 -- 23,192,031(+) TGCGG(C/T)GGGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTR1D Gene

Variant ID Type Subtype PubMed ID
nsv834424 CNV Loss 17160897

Variation tolerance for HTR1D Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HTR1D Gene

Disorders for HTR1D Gene

MalaCards: The human disease database

(5) MalaCards diseases for HTR1D Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
major depressive disorder and accelerated response to antidepressant drug treatment
  • unipolar depression
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search HTR1D in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1D

Genetic Association Database (GAD)
HTR1D
Human Genome Epidemiology (HuGE) Navigator
HTR1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1D
genes like me logo Genes that share disorders with HTR1D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1D Gene

Publications for HTR1D Gene

  1. The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. (PMID: 17099886) Li J. … Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006) 3 23 48 67
  2. Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery. (PMID: 15185063) JAohnichen S. … Pertz H.H. (Naunyn Schmiedebergs Arch. Pharmacol. 2004) 23 25 26
  3. The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. (PMID: 14728084) Stahl S.M. … Shayegan D.K. (J Clin Psychiatry 2003) 23 25 26
  4. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. (PMID: 11132243) Richelson E. … Souder T. (Life Sci. 2000) 23 25 26
  5. Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. (PMID: 10193663) Napier C. … Wallis R. (Eur. J. Pharmacol. 1999) 23 25 26

Products for HTR1D Gene

Sources for HTR1D Gene

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