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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HTR1D Gene

protein-coding GIFtS: 66
GCID: GC01M023517

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1D )
(Previous symbol: HTRL)

Explore 24 diseases affiliated with
HTR1D via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled¹ ²		5-HT-1D² ³
5-HT1D¹ ² ³		5-HT-1D-Alpha¹
HTRL¹ ² ³		HTR1DA² ³
HT1DA¹ ²		5-Hydroxytryptamine (Serotonin) Receptor 1D¹
RDC4¹ ²		5-Hydroxytryptamine Receptor 1D²
Serotonin Receptor 1D² ³		Serotonin 1D Alpha Receptor³

External Ids:	HGNC: 5289¹	Entrez Gene: 3352²	Ensembl: ENSG00000179546⁷	OMIM: 182133⁵	UniProtKB: P28221³

Export aliases for HTR1D gene to outside databases

Previous GC identifers: GC01M023088 GC01M022554 GC01M022664 GC01M022987 GC01M023263 GC01M023389 GC01M021762

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

summary for HTR1D:

Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal

ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to

be involved in anxiety, depression, and other neuropsychiatric disorders. The human 5-HT1D receptor gene has

been localized to chromosome 1 (1p34.3-36.3).

Gene Wiki entry for HTR1D (5-HT1D receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HTR1D gene promoter:
GATA-3 CUTL1 HNF-3beta GATA-1 GATA-2 SRY STAT3 FOXO1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTR1D promoter sequence

Search SABiosciences Chromatin IP Primers for HTR1D

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1D

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3-p34.3 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.3-p34.3

HTR1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1D gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M023517: view genomic region (about GC identifiers)

Start:	23,516,993 bp from pter	End:	23,521,222 bp from pter
Size:	4,230 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 1D

Size: 377 amino acids; 41907 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for HTR1D: NX_P28221

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28221

HTR1D Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000855.1

ENSEMBL proteins:

ENSP00000363748 ENSP00000313661

Reactome Protein details: P28221
Human Recombinant Protein Products:

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	Uscn Proteins for HTR1D

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1652050

HTR1D for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HTR1D

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HTR1D for domains About GeneDecksing

4 InterPro domains/families:

IPR000505 5HT1D_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR002231 5HT_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P28221

ProtoNet protein and cluster: P28221

2 Blocks protein families:

IPB000505 5-hydroxytryptamine 1D receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 5HT1D_HUMAN, P28221

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

Genatlas biochemistry entry for HTR1D:

5-hydroxytryptamine (serotonin) receptor,subtype 1.D,alpha,expressed in brain cortex,G protein coupled receptor

superfamily,inhibiting adenylate cyclase

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTR1D
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HTR1D (see all 10):
		hsa-miR-379 hsa-miR-100* hsa-miR-3140-3p hsa-miR-18a hsa-miR-888 hsa-miR-3927 hsa-miR-130b* hsa-miR-330-3p

		SwitchGear 3'UTR luciferase reporter plasmid: HTR1D 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HTR1D

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		Search LifeMap BioReagents cell lines for HTR1D

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1D

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004993	serotonin receptor activity	IEA	--
GO:0051378	serotonin binding	IEA	--

HTR1D for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HTR1D:

Increased S DNA content

Animal Models:
Mouse knock-out Htr1d^tm1Lex for HTR1D
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Htr1d):

normal

HTR1D for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Monoamine GPCRs

	Monoamine GPCRs	1.00			Serotonin receptors	0.36
	Amine ligand-binding receptors	0.79			Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics	0.20

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

CREB Pathway

Intracellular Calcium Signaling

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1D

Intracellular Calcium Signaling

2 BioSystems Pathways for HTR1D

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/8 Reactome Pathways for HTR1D (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Serotonin receptors

1 PharmGKB Pathway for HTR1D

Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for HTR1D):

Neuroactive ligand-receptor interaction

HTR1D for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HTR1D

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/143 Interacting proteins for HTR1D (P28221³ ENSP00000313661⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 143)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTR1A	P08908³, ENSP00000316244⁴	I2D: score=3 STRING: ENSP00000316244
HTR1B	P28222³, ENSP00000358963⁴	I2D: score=3 STRING: ENSP00000358963
S1PR1	P21453³, ENSP00000305416⁴	I2D: score=3 STRING: ENSP00000305416
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADORA1	ENSP00000308549⁴	STRING: ENSP00000308549

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1565658
GO:0007210	serotonin receptor signaling pathway	--	--
GO:0007268	synaptic transmission	TAS	1565658
GO:0009636	response to toxin	IEA	--
GO:0014827	intestine smooth muscle contraction	IMP	9186750

HTR1D for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HTR1D for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HTR1D available from Tocris Bioscience About this table

Compound	Action	CAS #
L-703,664 succinate	Selective 5-HT1D receptor agonist	[144776-01-2]
GR 46611	5-HT1D agonist	[185259-85-2]
LY 310762 hydrochloride	5-HT1D-preferring antagonist	[192927-92-7]
PNU 109291	Potent and selective 5-HT1D agonist	[187665-60-7]
BRL 15572 hydrochloride	Selective h5-HT1D antagonist	[193611-72-2]

2 HMDB Compounds for HTR1D About this table

Compound	Synonyms	CAS #	PubMed Ids
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--
Sumatriptan	Imigran (see all 4)	103628-46-2	--

10/24 DrugBank Compounds for HTR1D (see all 24) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Naratriptan	--	121679-13-8	target	agonist	12010764 8741180 12463278 11897116 10410185 14728705 14725972 11152011 11752352 16389295 20687618 10563228
Frovatriptan	--	158747-02-5	target	agonist	9700983 11735616 15342617 15185063 10883409 11152011 12028320 11752352 12028322 18360605 15311727
Sumatriptan	NP101 (see all 4)	103628-46-2	target	agonist	12110114 11641558 18723285 10772044 15554784 10454495 12010765 11874390 11752352 10225363 11313163
Zolmitriptan	--	139264-17-8	target	agonist	11513839 11594437 10463324 20407761 10844127 9399012 15096229 11752352 9859690 10563228
Rizatriptan	MK 462 Free Base (see all 4)	145202-66-0	target	agonist	12269863 9127118 11487512 12093318 15056946 8904614 11752352 9056052 15821444
Dihydroergotamine	9,10-dihydro-ergotamine (see all 6)	6190-39-2	target	agonist	1407010 1324091 12558771 9605573 11752352 14744615 1379707
Eletriptan	--	143322-58-1	target	agonist	11513839 12498013 11152011 10193663 11752352 15821444
Ergotamine	--	113-15-5	target	agonist	1407010 12558771 14504136 8384716 1646776
Ziprasidone	Ziprasidone hydrochloride (see all 2)	146939-27-7	target	antagonist	14728084 11910268 10516958 7562537 11132243
Almotriptan	--	181183-52-8	target	agonist	11134654 11642004 11752352 10193663

10/34 Novoseek chemical compound relationships for HTR1D gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sumatriptan	90.6	14	1326402 (2), 8164519 (1), 8384716 (1), 7516861 (1) (see all 13)
ly 344864	89.2	3	12434581 (1), 10711348 (1), 15320857 (1)
gr 127935	87.4	4	8938651 (1), 8741180 (1), 9278519 (1)
5-carboxamidotryptamine	87.1	4	8164519 (1), 14965240 (1), 8384716 (1)
methiothepin	83.4	3	2043924 (1), 8978753 (1), 8903941 (1)
naratriptan	83.4	3	8741180 (2), 10193663 (1)
zolmitriptan	83	4	9154322 (1), 9071266 (1), 10193663 (1), 9350394 (1)
metergoline	82	2	8938651 (1), 2043924 (1)
5-hydroxytryptamine	78.8	12	2043924 (2), 9335552 (1), 9016944 (1), 8232238 (1) (see all 10)
rizatriptan	77.9	1	10193663 (1)

Search CenterWatch for drugs/clinical trials and news about HTR1D / 5HT1D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HTR1D gene:

NM_000864.4

Unigene Cluster for HTR1D:

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled

Hs.121482 [show with all ESTs]

Unigene Representative Sequence: NM_000864

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374619(uc001bgn.3) ENST00000314113

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTR1D
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR1D

Additional cDNA sequence:

AF498979.1 BC007720.2 BT007027.1 M81589.1

1 DOTS entry:

DT.75136214

10 AceView cDNA sequences:

NM_000864 BT007027 AF498979 BC007720 M81589 AA132509 BF196846 BX281878

BF688599 AW051032

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HTR1D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAAAAAA

About this image

HTR1D expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Matrigel embedded cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HTR1D Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR1D

SOURCE GeneReport for Unigene cluster: Hs.121482

SABiosciences Expression via Pathway-Focused PCR Arrays including HTR1D:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HTR1D gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HTR1D¹	5-hydroxytryptamine (serotonin) receptor 1D	71.62(n) 79.84(a)		769107 XM_003642559.1 XP_003642607.1
lizard (Anolis carolinensis)	Reptilia	HTR1D⁶	--	77(a)	1 ↔ 1	AAWZ02038557(5595-6725)
zebrafish (Danio rerio)	Actinopterygii	htr1bd¹	5-hydroxytryptamine (serotonin) receptor 1bd	70.33(n) 72.68(a)		556429 NM_001145686.1 NP_001139158.1
fruit fly (Drosophila melanogaster)	Insecta	DopR2³ 5-HT1B¹	dopamine receptor signaling pathway dopamine receptor³ Serotonin receptor 1B¹	45(a) (best of 5)³ 55.77(n)¹ 45.28(a)¹		3 99B5³ 37191¹ NM_001169730.2¹ NP_001163201.1¹
worm (Caenorhabditis elegans)	Secernentea	M03F4.3³	G-protein coupled receptor	37(a)		X(4985611-4990413) --

ENSEMBL Gene Tree for HTR1D (if available)
TreeFam Gene Tree for HTR1D (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HTR1D gene

DRD4² HTR1A² ADRA1B² DRD2² HTR1F² HTR7² ADRA2C² ADRA2A²

ADRA1A² ADRA2B² HTR1E² DRD3² HTR5A² HTR1B² ADRA1D²

18/23 SIMAP similar genes for HTR1D using alignment to 1 protein entry: 5HT1D_HUMAN(see all similar genes):

HTR1B HTR1F HTR1E 5HT1A HTR1A HTR5A

DRD1 HTR7 ADRA1D ADRB1 ADRB2 ADRA1A

HTR2A HTR2B DRD3 ADRA1B HTR2C ADRA2C

HTR1D for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HTR1D
PGOHUM00000239288

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188942220^1,2		--	23518081(+)	`TTTGTA/GTTTTT`	1	--	int¹		0	--	--	--	--
rs6667537^1,2	C,	--	23518147(+)	`AAGCAA/GTCCTC`	1	--	int¹		2		NA	4
rs140425961^1,2		--	23518153(+)	`TCCTCA/CCACCT`	1	--	int¹		0	--	--	--	--
rs604030^1,2	C,F,O,A,H,	--	23518227(+)	`CATCAT/CGCTAT`	1	--	int¹		19		NS EA NA WA	1324
rs181631570^1,2		--	23518289(+)	`TGGGAA/CCTGGC`	1	--	int¹		0	--	--	--	--
rs187203916^1,2		--	23518440(+)	`AATGAA/GTTTTC`	1	--	ut3¹		0	--	--	--	--
rs3215906^1,2	C,F,	--	23518471(-)	`TTTTT-/TAACAT`	1	--	ut3¹		6		MN CSA	398
rs605367^1,2	C,F,A,	--	23518524(+)	`TGCGGT/CGGGTG`	1	--	ut3¹ ese³		18		EA NA MN WA CSA	889
rs190373388^1,2		--	23518717(+)	`ATCATC/TGGCAC`	1	--	ut3¹		0	--	--	--	--
rs182575460^1,2		--	23518746(+)	`CTTCAC/TGGACA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HTR1D (23516993 - 23521222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HTR1D: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HTR1D for disorders           About GeneDecksing

OMIM gene information: 182133    OMIM disorders: --

20/24 diseases for HTR1D (see all 24):    About MalaCards

obsessive-compulsive disorder attention deficit hyperactivity disorder borderline personality disorder cluster headache

personality disorder anorexia nervosa eating disorder headache

migraine with aura migraine was-related disorders myoclonus

bipolar disorder hermaphroditism pulmonary disease schizophrenia

pharyngitis lung carcinoma astrocytoma cerebritis

1 disease from the University of Copenhagen DISEASES database for HTR1D:

Migraine

4 Novoseek disease relationships for HTR1D gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
migraine	67.3	12	9949863 (3), 1871321 (1), 1326402 (1), 7658443 (1) (see all 10)
schizophrenia	14.7	1	8104876 (1)
genetic susceptibility	1.85	1	17572793 (1)
inflammation	0	2	9071266 (1), 9243618 (1)

Genetic Association Database (GAD): HTR1D
Human Genome Epidemiology (HuGE) Navigator: HTR1D (26 documents)

Export disorders for HTR1D gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HTR1D gene, integrated from 9 sources (see all 219):
(articles sorted by number of sources associating them with HTR1D)

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Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. (PubMed id 1565658)^{1, 2, 9} Weinshank R.L....Hartig P.R. (1992)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
[Lack of association between the G681C polimorphism in the 5-HT1D(beta) autoreceptor gene and schizophrenia.] (PubMed id 16059583)^{1, 4} Cordeiro Q. and Vallada H. (2005)
Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms. (PubMed id 15109354)^{1, 4} Racchi M....Bussone G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. (PubMed id 12627464)^{1, 4} Turecki G....Rouleau G.A. (2003)
Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. (PubMed id 12650952)^{1, 4} Hemmings S.M....Stein D.J. (2003)
Characterization of single-nucleotide polymorphisms in coding regions of human genes. (PubMed id 10391209)^{1, 2} Cargill M....Lander E.S. (1999)
Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. (PubMed id 1662665)^{1, 3} Libert F....Mattei M.G. (1991)
Primary structure and functional characterization of a human 5-HT1D- type serotonin receptor. (PubMed id 1652050)^{1, 2} Hamblin M.W. and Metcalf M.A. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3352	HGNC: 5289	AceView: HTR1D	Ensembl:ENSG00000179546	euGenes: HUgn3352
ECgene: HTR1D	Kegg: 3352	H-InvDB: HTR1D

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HTR1D	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HTR1D	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HTR1D gene
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Patent Information for HTR1D gene:
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HTR1D Gene

5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled

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5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled

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