Aliases for HTR1D Gene
External Ids for HTR1D Gene
Previous Symbols for HTR1D Gene
GeneCards Summary for HTR1D Gene
HTR1D (5-Hydroxytryptamine (Serotonin) Receptor 1D, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1D include schizophrenia and migraine. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include serotonin receptor activity and serotonin binding. An important paralog of this gene is HTR1F.
UniProtKB/Swiss-Prot for HTR1D Gene
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Serotonin 5-HT1D receptors, previously known as 5-HT1Dalpha receptors, are located primarily in the basal ganglia, hippocampus, cortex, spinal cord and vascular smooth muscle cells. 5-HT1D receptors are thought to be involved in anxiety, depression, and other neuropsychiatric disorders. The human 5-HT1D receptor gene has been localized to chromosome 1 (1p34.3-36.3).