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Aliases for HTR1B Gene

Aliases for HTR1B Gene

  • 5-Hydroxytryptamine Receptor 1B 2 3 5
  • 5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled 2 3
  • Serotonin 1D Beta Receptor 3 4
  • Serotonin Receptor 1B 3 4
  • 5-HT-1D-Beta 3 4
  • 5-HT-1B 3 4
  • 5-HT1B 3 4
  • HTR1DB 3 4
  • S12 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1B 2
  • 5-HT1DB 3
  • HTR1D2 3

External Ids for HTR1B Gene

Previous GeneCards Identifiers for HTR1B Gene

  • GC06M078114
  • GC06M078167
  • GC06M078228
  • GC06M075364
  • GC06M078171
  • GC06M077462
  • GC06M077465
  • GC06M077468

Summaries for HTR1B Gene

Entrez Gene Summary for HTR1B Gene

  • The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

GeneCards Summary for HTR1B Gene

HTR1B (5-Hydroxytryptamine Receptor 1B) is a Protein Coding gene. Diseases associated with HTR1B include Prinzmetal's Variant Angina and Obsessive-Compulsive Disorder. Among its related pathways are Serotonergic synapse and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1D.

UniProtKB/Swiss-Prot for HTR1B Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Tocris Summary for HTR1B Gene

  • Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

Gene Wiki entry for HTR1B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1B Gene

Genomics for HTR1B Gene

Regulatory Elements for HTR1B Gene

Enhancers for HTR1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G077368 1.1 Ensembl ENCODE 9.9 +95.1 95073 1.4 ZSCAN4 ZNF76 RBBP5 ZBTB48 POLR2A PATZ1 SCRT2 ZNF600 PRDM10 RELB HTR1B ENSG00000276064 LOC105377864
GH06G077440 0.6 ENCODE 11.7 +22.9 22918 1.2 MAFF ZNF316 MAFG FOS EMSY MAFK HTR1B GC06M077473 PIR53767 LOC105377864
GH06G077502 0.2 ENCODE 10.9 -39.4 -39413 0.9 HTR1B GC06P077496 MEI4
GH06G077465 1.1 Ensembl ENCODE 0.7 -2.7 -2713 1.8 ZSCAN4 WRNIP1 RAD21 ZBTB40 YY1 ETS1 CBX5 ELK1 RELB IKZF2 HTR1B PIR46542
GH06G077454 1.1 Ensembl ENCODE 0.7 +4.1 4122 11.0 ZNF76 KLF17 ZNF2 RAD21 GLIS2 GATA2 SCRT2 KLF7 FOS ZNF654 GC06M077471 PIR51005 HTR1B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTR1B on UCSC Golden Path with GeneCards custom track

Promoters for HTR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199126 -527 201 MXI1 ZNF777 ZNF76 KLF17 RBBP5 GLIS2 POLR2A PATZ1 ZNF600 PRDM10

Genomic Location for HTR1B Gene

Chromosome:
6
Start:
77,461,753 bp from pter
End:
77,463,773 bp from pter
Size:
2,021 bases
Orientation:
Minus strand

Genomic View for HTR1B Gene

Genes around HTR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1B Gene

Proteins for HTR1B Gene

  • Protein details for HTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28222-5HT1B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1B
    Protein Accession:
    P28222
    Secondary Accessions:
    • Q4VAY7

    Protein attributes for HTR1B Gene

    Size:
    390 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • Homodimer. Heterodimer with HTR1D.
    Miscellaneous:
    • A residue in the 7th transmembrane region (Thr-355 in human, Asn-351 in mouse and rat) is important for species-specific sensitivity to various agonists.

    Three dimensional structures from OCA and Proteopedia for HTR1B Gene

neXtProt entry for HTR1B Gene

Post-translational modifications for HTR1B Gene

Other Protein References for HTR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1B Gene

Domains & Families for HTR1B Gene

Suggested Antigen Peptide Sequences for HTR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28222

UniProtKB/Swiss-Prot:

5HT1B_HUMAN :
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1B: view

Function for HTR1B Gene

Molecular function for HTR1B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1D beta,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Gene Ontology (GO) - Molecular Function for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IDA 1315531
GO:0005515 protein binding IPI 25416956
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with HTR1B: view
genes like me logo Genes that share phenotypes with HTR1B: view

Animal Models for HTR1B Gene

MGI Knock Outs for HTR1B:

Animal Model Products

CRISPR Products

miRNA for HTR1B Gene

miRTarBase miRNAs that target HTR1B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR1B

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR1B Gene

Localization for HTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTR1B gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP,TAS 1315531
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HTR1B: view

Pathways & Interactions for HTR1B Gene

genes like me logo Genes that share pathways with HTR1B: view

Gene Ontology (GO) - Biological Process for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1559993
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 1315531
genes like me logo Genes that share ontologies with HTR1B: view

No data available for SIGNOR curated interactions for HTR1B Gene

Drugs & Compounds for HTR1B Gene

(206) Drugs for HTR1B Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naratriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 15
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 5-HT1 receptor agonist 101
Zolmitriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 18
Dihydroergotamine Approved Pharma Full agonist, Agonist, agonist, Target 10
Rizatriptan Approved Pharma Full agonist, Agonist, agonist, Target 35

(15) Additional Compounds for HTR1B Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-flurocarazolol
Antagonist
(S)-flurocarazolol
Antagonist
5-HT
Full agonist, Agonist
N-Desmethyleletriptan

(5) Tocris Compounds for HTR1B Gene

Compound Action Cas Number
CP 94253 hydrochloride Potent, selective 5-HT1B agonist 845861-39-4
GR 127935 hydrochloride Potent, selective 5-HT1B/1D antagonist 148642-42-6
GR 55562 dihydrochloride 5-HT1B antagonist 159533-25-2
SB 216641 hydrochloride Selective h5-HT1B antagonist 193611-67-5
SB 224289 hydrochloride Selective 5-HT1B antagonist 180084-26-8

(90) ApexBio Compounds for HTR1B Gene

Compound Action Cas Number
(±)-MDMA hydrochloride 92279-84-0
2-Methyl-5-hydroxytryptamine hydrochloride 845861-49-6
5-Carboxamidotryptamine maleate 74885-72-6
5-Nonyloxytryptamine oxalate 157798-13-5
Almotriptan Malate 5-HT1B/1D-receptor agonist 181183-52-8
Anpirtoline hydrochloride 99201-87-3
Asenapine Inhibits adrenergic receptor/5-HT receptor 85650-56-2
Asenapine hydrochloride Atypical antipsychotic 1412458-61-7
Bilobalide Neuroprotective agent 33570-04-6
Blonanserin Atypical antipsychotic 132810-10-7
BTS 54-505 hydrochloride Potent SNRI,sibutramine metabolite 84484-78-6
CGS 12066B dimaleate 109028-10-6
Cisapride 81098-60-4
Clomipramine HCl SERT/NET dopamine transporter (DAT) blocker 17321-77-6
Clozapine N-oxide Metabolite of clozapine 34233-69-7
CP 93129 dihydrochloride 879089-64-2
CP 94253 hydrochloride 845861-39-4
Cyanopindolol hemifumarate 69906-86-1
Dapoxetine HCl Selective serotonin reuptake inhibitor 129938-20-1
Desvenlafaxine 93413-62-8
Desvenlafaxine Succinate 386750-22-7
Dexfenfluramine hydrochloride 3239-45-0
Dihydroergotamine mesylate 6190-39-2
DOB hydrochloride 29705-96-2
DOI hydrochloride 42203-78-1
Donitriptan hydrochloride 170911-68-9
Duloxetine HCl 136434-34-9
Eletriptan HBr 177834-92-3
Eltoprazine hydrochloride 98206-09-8
Escitalopram Oxalate Serotonin(5-HT) reuptake (SSRI) inhibitor 219861-08-2
Fenspiride HCl 5053-08-7
Fluoxetine HCl Serotonin reuptake inhibitor,selective 56296-78-7
Fluvoxamine maleate Serotonin reuptake inhibitor,selective,antidepressant 61718-82-9
GR 127935 hydrochloride 148642-42-6
GR 46611 185259-85-2
GR 55562 dihydrochloride 159533-25-2
Isamoltane hemifumarate 874882-92-5
Ketanserin 74050-98-9
Lorcaserin HCl 846589-98-8
LY 393558 271780-64-4
LY310762 192927-92-7
m-CPP hydrochloride 13078-15-4
Methiothepin maleate 19728-88-2
Methylergometrine maleate 57432-61-8
Methysergide maleate 129-49-7
Milnacipran HCl 101152-94-7
Mosapride Citrate 5-HT receptor agonist 112885-42-4
MS 245 oxalate 275363-58-1
NAD 299 hydrochloride 184674-99-5
Naratriptan 143388-64-1
NAS-181 1217474-40-2
Olanzapine 132539-06-1
Ondansetron 99614-02-5
Ondansetron hydrochloride dihydrate 103639-04-9
Palonosetron HCl 135729-62-3
Pizotifen 15574-96-6
Pizotifen Malate 5189-11-7
Psilocin 520-53-6
Risperidone SR-2A inhibitor 106266-06-2
Rizatriptan Benzoate 145202-66-0
RS 39604 hydrochloride 167710-87-4
RS 67333 hydrochloride 168986-60-5
RU 24969 66611-26-5
Sarpogrelate hydrochloride 135159-51-2
SB 200646 hydrochloride 143797-62-0
SB 203186 hydrochloride 207572-69-8
SB 204070 148688-01-1
SB 216641 hydrochloride 193611-67-5
SB 224289 hydrochloride 180084-26-8
SB 242084 1215566-78-1
SB 243213 dihydrochloride 200940-23-4
SB 258719 hydrochloride 1217674-10-6
SB271046 209481-20-9
SEA0400 Specific inhibitor of Na+/Ca2+ exchange 223104-29-8
Sertraline HCl 79559-97-0
Sumatriptan 5-HT1 receptor agonist 103628-46-2
Sumatriptan Succinate 5-HT1 receptor agonist 103628-48-4
Tandospirone Anxiolytic and antidepressant reagent 87760-53-0
Tianeptine sodium 5-HT uptake facilitator,selective,antidepressant 30123-17-2
Trazodone HCl Antidepressant 25332-39-2
Tropisetron 105826-92-4
Urapidil HCl 64887-14-5
Venlafaxine Dual serotonin/noradrenalin re-uptake inhibitor 99300-78-4
Vortioxetine 5-HT receptors antagonist 508233-74-7
Vortioxetine (Lu AA21004) HBr 5-HT receptor modulator, antidepressant and anxiolytic 960203-27-4
VUF 10166 155584-74-0
WY 45233 succinate 448904-47-0
Ziprasidone HCl Serotonin and dopamine receptor antagonist 122883-93-6
Ziprasidone hydrochloride monohydrate 5-HT (serotonin)/dopamine receptor antagonist 138982-67-9
Zolmitriptan 139264-17-8
genes like me logo Genes that share compounds with HTR1B: view

Drug Products

Transcripts for HTR1B Gene

mRNA/cDNA for HTR1B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1B Gene

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTR1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1B Gene

No ASD Table

Relevant External Links for HTR1B Gene

GeneLoc Exon Structure for
HTR1B
ECgene alternative splicing isoforms for
HTR1B

Expression for HTR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTR1B Gene

mRNA differential expression in normal tissues according to GTEx for HTR1B Gene

This gene is overexpressed in Artery - Tibial (x9.1), Artery - Coronary (x6.7), and Artery - Aorta (x5.7).

Protein differential expression in normal tissues from HIPED for HTR1B Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1B Gene



Protein tissue co-expression partners for HTR1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTR1B Gene:

HTR1B

SOURCE GeneReport for Unigene cluster for HTR1B Gene:

Hs.123016

mRNA Expression by UniProt/SwissProt for HTR1B Gene:

P28222-5HT1B_HUMAN
Tissue specificity: Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.

Evidence on tissue expression from TISSUES for HTR1B Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with HTR1B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTR1B Gene

Orthologs for HTR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR1B 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia HTR1B 34
  • 92.03 (n)
mouse
(Mus musculus)
Mammalia Htr1b 34 16 35
  • 89.76 (n)
rat
(Rattus norvegicus)
Mammalia Htr1b 34
  • 89.72 (n)
cow
(Bos Taurus)
Mammalia HTR1B 34 35
  • 89.6 (n)
oppossum
(Monodelphis domestica)
Mammalia HTR1B 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1B 34 35
  • 79.93 (n)
lizard
(Anolis carolinensis)
Reptilia HTR1B 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495915 34
  • 68.56 (n)
zebrafish
(Danio rerio)
Actinopterygii htr1b 34 35
  • 65.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta DopR2 36
  • 46 (a)
5-HT1A 36
  • 44 (a)
5-HT1B 36
  • 42 (a)
5-HT7 36
  • 36 (a)
CG7431 36
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea tyra-2 34
  • 49.52 (n)
C09B7.1a 36
  • 32 (a)
C09B7.1b 36
  • 32 (a)
F14D12.6 36
  • 32 (a)
Species where no ortholog for HTR1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1B Gene

ENSEMBL:
Gene Tree for HTR1B (if available)
TreeFam:
Gene Tree for HTR1B (if available)

Paralogs for HTR1B Gene

(18) SIMAP similar genes for HTR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1B: view

Variants for HTR1B Gene

Sequence variations from dbSNP and Humsavar for HTR1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1002111567 -- 77,461,557(+) CACCC(A/C)CCCCC intron-variant, utr-variant-3-prime
rs1002400822 -- 77,461,229(+) ACACT(C/T)TTCTT intron-variant, utr-variant-3-prime
rs1003089769 -- 77,464,823(+) TTGCC(A/G/T)TCCTT intron-variant, upstream-variant-2KB
rs1003467744 -- 77,466,013(+) AAGCC(C/T)CATTT intron-variant, upstream-variant-2KB
rs1003549925 -- 77,464,474(+) CCCTA(C/G/T)CTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR1B Gene

Variant ID Type Subtype PubMed ID
esv2759445 CNV loss 17122850
nsv1017082 CNV loss 25217958

Variation tolerance for HTR1B Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1B Gene

Human Gene Mutation Database (HGMD)
HTR1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1B Gene

Disorders for HTR1B Gene

MalaCards: The human disease database

(16) MalaCards diseases for HTR1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prinzmetal's variant angina
  • prinzmetal angina
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
premature ejaculation
personality disorder
  • character disorder
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards
Search HTR1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1B

Genetic Association Database (GAD)
HTR1B
Human Genome Epidemiology (HuGE) Navigator
HTR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1B
genes like me logo Genes that share disorders with HTR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1B Gene

Publications for HTR1B Gene

  1. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. (PMID: 19350534) Conner T.S. … Covault J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  2. Lack of association between five serotonin metabolism-related genes and medication overuse headache. (PMID: 19936617) Cevoli S. … Cortelli P. (J Headache Pain 2010) 3 22 46 64
  3. Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder. (PMID: 20010449) Silva H. … Bustamante M.L. (Psychiatr. Genet. 2010) 3 22 46 64
  4. Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms. (PMID: 20071033) Yasseen B. … Busto U.E. (Psychiatry Res 2010) 3 22 46 64
  5. [Association study of HTR1A and HTR1B with adolescent idiopathic scoliosis]. (PMID: 20388441) Wang H. … Qiu G.X. (Zhonghua Wai Ke Za Zhi 2010) 3 22 46 64

Products for HTR1B Gene

Sources for HTR1B Gene

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