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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HTR1B Gene

protein-coding GIFtS: 66
GCID: GC06M078171

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1B )

Explore 47 diseases affiliated with
HTR1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled¹ ²		Serotonin Receptor 1B² ³
5-HT1B¹ ² ³		5-HT-1B² ³
S12¹ ² ³		5-HT-1D-Beta¹
5-HT1DB¹ ²		HTR1DB² ³
HTR1D2¹ ²		5-Hydroxytryptamine (Serotonin) Receptor 1B¹
Serotonin 1D Beta Receptor² ³		5-Hydroxytryptamine Receptor 1B²

External Ids:	HGNC: 5287¹	Entrez Gene: 3351²	Ensembl: ENSG00000135312⁷	OMIM: 182131⁵	UniProtKB: P28222³

Export aliases for HTR1B gene to outside databases

Previous GC identifers: GC06M078114 GC06M078167 GC06M078228 GC06M075364

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR1B:

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a

multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or

migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of

their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous

system (Zifa and Fillion, 1992 (PubMed 1359584)). The serotonergic receptors belong to the multigene family of

receptors coupled to guanine nucleotide-binding proteins.(supplied by OMIM, Oct 2009)

UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

summary for HTR1B:

Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal

ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation,

respiration, appetite control, sexual behavior, aggression, and anxiety. The human 5-HT1B receptor gene has

been localized to chromosome 6 (6q13).

Gene Wiki entry for HTR1B (5-HT1B receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HTR1B gene promoter:
TBP GR ATF-2 GR-beta YY1 AREB6 CRE-BP1 TFIID GR-alpha MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTR1B promoter sequence

Search SABiosciences Chromatin IP Primers for HTR1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q13

HTR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1B gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M078171: view genomic region (about GC identifiers)

Start:	78,171,948 bp from pter	End:	78,173,490 bp from pter
Size:	1,543 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 1B

Size: 390 amino acids; 43568 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for HTR1B:

2G1X (3D)

Secondary accessions: Q4VAY7

Explore the universe of human proteins at neXtProt for HTR1B: NX_P28222

Post-translational modifications:

Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation¹

Palmitoylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P28222

HTR1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000854.1

ENSEMBL proteins:

ENSP00000358963

Reactome Protein details: P28222
Human Recombinant Protein Products:

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	Uscn Proteins for HTR1B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	1559993

HTR1B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HTR1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HTR1B for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002147 5HT1B_rcpt

IPR002231 5HT_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P28222

ProtoNet protein and cluster: P28222

2 Blocks protein families:

IPB002147 5-hydroxytryptamine 1B receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

Genatlas biochemistry entry for HTR1B:

5-hydroxytryptamine (serotonin) receptor,subtype 1D beta,expressed in brain cortex,G protein coupled receptor

superfamily,inhibiting adenylate cyclase

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004993	serotonin receptor activity	IEA	--
GO:0008144	drug binding	IEA	--
GO:0051378	serotonin binding	IEA	--

HTR1B for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for HTR1B: Htr1b^tm2Rhn Htr1b^tm1Rhn
     8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Htr1b):

behavior/neurological	cardiovascular system	endocrine/exocrine gland	growth/size	muscle
no phenotypic analysis	reproductive system	skeleton

HTR1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Monoamine GPCRs

	Monoamine GPCRs	1.00			Serotonin receptors	0.36
	Amine ligand-binding receptors	0.79			Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics	0.20

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

CREB Pathway

Intracellular Calcium Signaling

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1B

Intracellular Calcium Signaling

2 BioSystems Pathways for HTR1B

	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/8 Reactome Pathways for HTR1B (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Serotonin receptors

1 PharmGKB Pathway for HTR1B

Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for HTR1B):

Neuroactive ligand-receptor interaction

HTR1B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HTR1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/147 Interacting proteins for HTR1B (P28222³ ENSP00000358963⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 147)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NME2	P22392³, ENSP00000365572⁴	I2D: score=2 STRING: ENSP00000365572
NME1-NME2	P22392³	I2D: score=2
HTR1A	P08908³, ENSP00000316244⁴	I2D: score=2 STRING: ENSP00000316244
HTR1D	P28221³, ENSP00000313661⁴	I2D: score=3 STRING: ENSP00000313661
GSTK1	Q9Y2Q3³	I2D: score=2

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002031	G-protein coupled receptor internalization	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	TAS	1315531
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	1559993
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	--
GO:0007210	serotonin receptor signaling pathway	--	--

HTR1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HTR1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HTR1B available from Tocris Bioscience About this table

Compound	Action	CAS #
NAS-181	Selective r5-HT1B antagonist. Active in vivo	[205242-62-2]
GR 127935 hydrochloride	Potent, selective 5-HT1B/1D antagonist	[148672-13-3]
CP 94253 hydrochloride	Potent, selective 5-HT1B agonist	[131084-35-0]
SB 224289 hydrochloride	Selective 5-HT1B antagonist	[180083-23-2]

4 HMDB Compounds for HTR1B About this table

Compound	Synonyms	CAS #	PubMed Ids
Propranolol	Dociton (see all 8)	525-66-6	--
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--
Sumatriptan	Imigran (see all 4)	103628-46-2	--
Venlafaxine	Efectin (see all 6)	93413-69-5	--

10/26 DrugBank Compounds for HTR1B (see all 26) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Frovatriptan	--	158747-02-5	target	agonist	17190530 9700983 11735616 15342617 18001261 10883409 11152011 12028320 11752352 12028322 18360605 15311727
Sumatriptan	NP101 (see all 4)	103628-46-2	target	agonist	12110114 10101238 18723285 10772044 10454495 12010765 10458598 11874390 11752352 10513577 10225363
Naratriptan	--	121679-13-8	target	agonist	12010764 12463278 10410185 14728705 14725972 11152011 11752352 9650800 16389295 20687618
Zolmitriptan	--	139264-17-8	target	agonist	11513839 11594437 10463324 20407761 10844127 9399012 15096229 11752352 9859690 10563228
Rizatriptan	MK 462 Free Base (see all 4)	145202-66-0	target	agonist	12269863 11487512 12093318 15056946 11752352 15821444 9650800
Almotriptan	--	181183-52-8	target	agonist	11134654 10824628 11752352 10193663 11069595 11050304
Eletriptan	--	143322-58-1	target	agonist	11513839 12384251 11752352 10193663 11069595 11050304
Bopindolol	--	69010-88-4	target	--	10727715 7944828 2512511 3141589 2664084
Dihydroergotamine	9,10-dihydro-ergotamine (see all 6)	6190-39-2	target	agonist	10455274 8622623 14744615 9650800 1660351
Pindolol	Betapindol (see all 2)	13523-86-9	target	other/unknown	10727715 7944828 2512511 3141589 2664084

10/48 Novoseek chemical compound relationships for HTR1B gene (see all 48) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sumatriptan	88.8	20	17217931 (2), 9871581 (2), 11972574 (2), 11234673 (1) (see all 16)
sb224289	88.6	3	11972574 (1), 16002749 (1), 17457631 (1)
naratriptan	86.3	5	10321110 (1), 11152011 (1), 9170336 (1), 10193663 (1) (see all 5)
5-carboxamidotryptamine	83.6	3	9225278 (1), 14965240 (1), 1559993 (1)
zolmitriptan	82.6	6	9154322 (1), 9871581 (1), 11152011 (1), 9071266 (1) (see all 6)
methiothepin	80.8	1	9225276 (1)
ketanserin	80	7	9225278 (1), 8741180 (1), 9548813 (1), 17521295 (1) (see all 7)
5-hydroxytryptamine	79.7	52	9384503 (3), 10381763 (2), 18035351 (2), 9723944 (2) (see all 27)
gr46611	76.2	1	15152026 (1)
ru 24969	75.7	6	9266609 (2), 1410132 (2), 19013555 (1)

Search CenterWatch for drugs/clinical trials and news about HTR1B / 5HT1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HTR1B gene:

NM_000863.1

Unigene Cluster for HTR1B:

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

Hs.123016 [show with all ESTs]

Unigene Representative Sequence: AK290080

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369947(uc003pil.1)

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Additional cDNA sequence:

AK290080.1 AK315325.1 BC069065.1 BC096206.1 BC096207.1 BC096208.1 M81590.1

1 DOTS entry:

DT.308845

4 AceView cDNA sequences:

M81590 BC069065 NM_000863 BV198054

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HTR1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAATGAGG

About this image

HTR1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HTR1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR1B

SOURCE GeneReport for Unigene cluster: Hs.123016

SABiosciences Expression via Pathway-Focused PCR Arrays including HTR1B:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HTR1B gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HTR1B¹	5-hydroxytryptamine (serotonin) receptor 1B	80.05(n) 85.37(a)		421858 NM_001172781.1 NP_001166252.1
lizard (Anolis carolinensis)	Reptilia	HTR1B⁶	--	81(a)	1 ↔ 1	1(200375591-200376766)
zebrafish (Danio rerio)	Actinopterygii	htr1b¹	5-hydroxytryptamine (serotonin) receptor 1B	66.03(n) 67.48(a)		561647 NM_001128709.1 NP_001122181.1
fruit fly (Drosophila melanogaster)	Insecta	DopR2³ 5-HT7¹	dopamine receptor signaling pathway dopamine receptor³ Serotonin receptor 7¹	46(a) (best of 5)³ 51.78(n)¹ 40.24(a)¹		3 99B5³ 43669¹ NM_079860.2¹ NP_524599.1¹
worm (Caenorhabditis elegans)	Secernentea	C09B7.1b³	--	32(a) (best of 3)		X(2709003-2717449) --

ENSEMBL Gene Tree for HTR1B (if available)
TreeFam Gene Tree for HTR1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HTR1B gene

DRD4² HTR1A² ADRA1B² DRD2² HTR1F² HTR7² ADRA2C² ADRA2A²

HTR1D² ADRA2B² ADRA1A² HTR1E² DRD3² HTR5A² ADRA1D²

18 SIMAP similar genes for HTR1B using alignment to 1 protein entry: 5HT1B_HUMAN:

HTR1D HTR1F HTR1E 5HT1A HTR1A ADRA1D

ADRA1A ADRA1B HTR5A HTR2A HTR7 DRD1

ADRB1 ADRB2 DRD3 HTR2C ADRB3 HRH2

HTR1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139073439^1,2	C,	--	78171488(+)	`GTTCT-/CCCCCCA`	1	--	ds500¹		0	--	--	--	--
rs73469290^1,2	C,	--	78171519(+)	`GTCTAG/TTTCAA`	1	--	ds500¹		3		WA	122
rs191457115^1,2		--	78171578(+)	`AATTAC/GAAGTA`	1	--	ds500¹		0	--	--	--	--
rs116501140^1,2	C,F,	--	78171611(+)	`CCACGA/GTACCA`	1	--	ds500¹		1		WA	118
rs76194807^1,2	C,F,	--	78171615(+)	`GATACC/AAAAGC`	1	--	ds500¹		3		WA NA EA	358
rs144949072^1,2		--	78171645(+)	`ATTATA/CAATTT`	1	--	ds500¹		0	--	--	--	--
rs183156887^1,2		--	78171679(+)	`GATTGG/TCTGCC`	1	--	ds500¹		0	--	--	--	--
rs9361234^1,2	C,	--	78171682(+)	`TGGCTG/ACCGCA`	1	--	ds500¹		4		NA WA EA	360
rs73469291^1,2	C,F,	--	78171717(+)	`GAGGGG/AAGGAA`	1	--	ds500¹		3		WA CSA	122
rs140792648^1,2	C,	--	78171782(+)	`CAGAG-/CTCTCTC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HTR1B (78171948 - 78173490 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HTR1B
4 CNVs: 81456 93834 3621 81455
Human Gene Mutation Database (HGMD): HTR1B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR1B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HTR1B for disorders           About GeneDecksing

OMIM gene information: 182131    OMIM disorders: --

20/47 diseases for HTR1B (see all 47):    About MalaCards

migraine obsessive-compulsive disorder attention deficit hyperactivity disorder antisocial personality disorder

spinal cord injury personality disorder bulimia nervosa borderline personality disorder

temporal lobe epilepsy cluster headache premature ejaculation non-hodgkin lymphoma

major depressive disorder substance abuse heroin dependence autism spectrum disorder

sleep apnea mood disorder substance dependence alcohol abuse

6 diseases from the University of Copenhagen DISEASES database for HTR1B:

Antisocial personality disorder Alcohol dependence Migraine Attention deficit hyperactivity disorder

Intermittent explosive disorder Borderline personality disorder

10/18 Novoseek disease relationships for HTR1B gene (see all 18) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
migraine	69.5	12	9225278 (1), 11735616 (1), 8397171 (1), 17563839 (1) (see all 9)
attention-deficit hyperactivity disorder	63.1	3	15578613 (1), 16197923 (1), 16958036 (1)
obsessive-compulsive disorder	54.8	3	17241828 (1), 14731309 (1), 16958036 (1)
variant angina	47.2	2	16890312 (1), 16960982 (1)
alcoholism	45	23	19519719 (3), 9819067 (2), 12022963 (2), 11751038 (2) (see all 9)
aggressive behavior	43.7	4	14730192 (2), 9819067 (1), 12497617 (1)
psychiatric disorder	35.5	4	19809810 (1), 19921161 (1), 16344719 (1), 16958036 (1)
coronary spasm	33	3	16890312 (1), 16960982 (1)
antisocial personality disorder	31.2	3	19519719 (1), 9819067 (1)
bulimia nervosa	30.1	2	11690602 (2)

Genetic Association Database (GAD): HTR1B
Human Genome Epidemiology (HuGE) Navigator: HTR1B (96 documents)

Export disorders for HTR1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HTR1B gene, integrated from 9 sources (see all 412):
(articles sorted by number of sources associating them with HTR1B)

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world of online information

Characterization of the human 5-hydroxytryptamine1B receptor. (PubMed id 1348246)^{1, 2, 3} Jin H.... O'Dowd B.F. (1992)
Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism. (PubMed id 14730192)^{1, 4, 9} Hong C.J....Tsai S.J. (2004)
Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. (PubMed id 16344719)^{1, 4, 9} Proudnikov D....Kreek M.J. (2006)
No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. (PubMed id 15698927)^{1, 4, 9} Duan S....He L. (2005)
Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. (PubMed id 12022963)^{1, 4, 9} Sun H.F....Cheng A.T. (2002)
Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. (PubMed id 16197923)^{1, 4, 9} Smoller J.W....Faraone S.V. (2006)
Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. (PubMed id 11690602)^{1, 4, 9} Levitan R.D....Kennedy J.L. (2001)
Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder. (PubMed id 15365222)^{1, 4, 9} Tsai S.J....Lin W.K. (2004)
Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits. (PubMed id 14504413)^{1, 4, 9} Tsai S.J....Hong C.J. (2003)
Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence. (PubMed id 11751038)^{1, 4, 9} Kranzler H.R....Gelernter J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3351	HGNC: 5287	AceView: HTR1B	Ensembl:ENSG00000135312	euGenes: HUgn3351
ECgene: HTR1B	Kegg: 3351	H-InvDB: HTR1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HTR1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HTR1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HTR1B gene:
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GeneCards and IP:
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HTR1B Gene

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

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5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

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