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HTR1B Gene

protein-coding   GIFtS: 68
GCID: GC06M078171

5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled1 2     HTR1DB2 3
Serotonin 1D Beta Receptor2 3     S122 3
Serotonin Receptor 1B2 3     5-Hydroxytryptamine (Serotonin) Receptor 1B1
5-HT-1B2 3     5-HT1DB2
5-HT-1D-beta2 3     5-Hydroxytryptamine Receptor 1B2
5-HT1B2 3     HTR1D22

External Ids:    HGNC: 52871   Entrez Gene: 33512   Ensembl: ENSG000001353127   OMIM: 1821315   UniProtKB: P282223   

Export aliases for HTR1B gene to outside databases

Previous GC identifers: GC06M078114 GC06M078167 GC06M078228 GC06M075364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTR1B Gene:
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through
a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression,
or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the
basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution
within the nervous system (Zifa and Fillion, 1992 (PubMed 1359584)). The serotonergic receptors belong to the
multigene family of receptors coupled to guanine nucleotide-binding proteins.(supplied by OMIM, Oct 2009)

GeneCards Summary for HTR1B Gene:
HTR1B (5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1B include premature ejaculation, and antisocial personality disorder. GO annotations related to this gene include drug binding and serotonin binding. An important paralog of this gene is HTR1A.

UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot
alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as
lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine
nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate
cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins
and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine
and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception,
mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries

summary for HTR1B Gene:
Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal
ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation,
respiration, appetite control, sexual behavior, aggression, and anxiety. The human 5-HT1B receptor gene has
been localized to chromosome 6 (6q13).

Gene Wiki entry for HTR1B (5-HT1B receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR1B gene promoter:
         TBP   GR   ATF-2   GR-beta   YY1   AREB6   CRE-BP1   TFIID   GR-alpha   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1B promoter sequence
   Search Chromatin IP Primers for HTR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q13   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q13

HTR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M078171:  view genomic region     (about GC identifiers)

Start:
78,171,948 bp from pter      End:
78,173,490 bp from pter
Size:
1,543 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1B  
Size: 390 amino acids; 43568 Da
Subunit: Homodimer. Heterodimer with HTR1D
Miscellaneous: A residue in the 7th transmembrane region (Thr-355 in human, 'Asn-351' in mouse and rat) is
important for species-specific sensitivity to various agonists
3 PDB 3D structures from and Proteopedia for HTR1B:
2G1X (3D)        4IAQ (3D)        4IAR (3D)    
Secondary accessions: Q4VAY7

Explore the universe of human proteins at neXtProt for HTR1B: NX_P28222

Explore proteomics data for HTR1B at MOPED

Post-translational modifications: 

  • Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation1
  • Palmitoylated1
  • Glycosylation2 at Asn24, Asn32
  • Modification sites at PhosphoSitePlus

  • See HTR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000854.1  
    ENSEMBL proteins: 
     ENSP00000358963  
    Reactome Protein details: P28222

    HTR1B Human Recombinant Protein Products:

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    Novus Biologicals HTR1B Protein
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    Cloud-Clone Corp. CLIAs for HTR1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1B receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002147 5HT1B_rcpt
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P28222

    ProtoNet protein and cluster: P28222

    2 Blocks protein domains:
    IPB002147 5-hydroxytryptamine 1B receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222
    Domain: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices
    Similarity: Belongs to the G-protein coupled receptor 1 family


    HTR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1B_HUMAN, P28222
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot
    alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as
    lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine
    nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate
    cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins
    and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine
    and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception,
    mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries

         Genatlas biochemistry entry for HTR1B:
    5-hydroxytryptamine (serotonin) receptor,subtype 1D beta,expressed in brain cortex,G protein coupled receptor
    superfamily,inhibiting adenylate cyclase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IDA1315531
    GO:0008144drug binding IEA--
    GO:0051378serotonin binding IEA--
         
    HTR1B for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Htr1b):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body  muscle 
     no phenotypic analysis  reproductive system  skeleton 

    HTR1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR1B: Htr1btm2Rhn Htr1btm1Rhn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTR1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTR1B

    miRNA
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    miRTarBase miRNAs that target HTR1B:
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HTR1B

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HTR1B (NM_000863)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5HT1B_HUMAN, P28222: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP1315531
    GO:0016021integral component of membrane ----

    HTR1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTR1B About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR1B
        Intracellular Calcium Signaling

    2 BioSystems Pathways for HTR1B
        GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR1B
        Serotonin receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for HTR1B
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HTR1B):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR1B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1B: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HTR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR1B (P282223 ENSP000003589634) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223923, ENSP000003655724I2D: score=2 STRING: ENSP00000365572
    NME1-NME2P223923I2D: score=2 
    HTR1AP089083, ENSP000003162444I2D: score=2 STRING: ENSP00000316244
    HTR1DP282213, ENSP000003136614I2D: score=3 STRING: ENSP00000313661
    GSTK1Q9Y2Q33I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002031G-protein coupled receptor internalization IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS1559993
    GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA1315531
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--

    HTR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HTR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Anpirtoline hydrochlorideHighly potent 5-HT1B agonist. Also 5-HT3 antagonist[99201-87-3]
    CGS 12066B dimaleate5-HT1B agonist[109028-10-6]
    CP 94253 hydrochloride Potent, selective 5-HT1B agonist [131084-35-0]
    SB 216641 hydrochlorideSelective h5-HT1B antagonist[170230-39-4]
    SB 224289 hydrochlorideSelective 5-HT1B antagonist[180083-23-2]

    4 HMDB Compounds for HTR1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    PropranololDociton (see all 8)525-66-6--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    SumatriptanImigran (see all 4)103628-46-2--
    VenlafaxineEfectin (see all 6)93413-69-5--

    Selected DrugBank Compounds for HTR1B (see all 27)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Frovatriptan-- 158747-02-5targetagonist17190530 9700983 11735616 15342617 18001261 10883409 11152011 12028320 11752352 12028322 18360605 15311727
    SumatriptanNP101 (see all 4)103628-46-2targetagonist12110114 10101238 18723285 10772044 10454495 12010765 10458598 11874390 11752352 10513577 10225363
    Naratriptan-- 121679-13-8targetagonist12010764 12463278 10410185 14728705 14725972 11152011 11752352 9650800 16389295 20687618
    Zolmitriptan-- 139264-17-8targetagonist11513839 11594437 10463324 20407761 10844127 9399012 15096229 11752352 9859690 10563228
    RizatriptanMK 462 Free Base (see all 4)145202-66-0targetagonist12269863 11487512 12093318 15056946 11752352 15821444 9650800
    Almotriptan-- 181183-52-8targetagonist11134654 10824628 11752352 10193663 11069595 11050304
    Eletriptan-- 143322-58-1targetagonist11513839 12384251 11752352 10193663 11069595 11050304
    Bopindolol-- 69010-88-4target--10727715 7944828 2512511 3141589 2664084
    Dihydroergotamine9,10-dihydro-ergotamine (see all 6)6190-39-2targetagonist10455274 8622623 14744615 9650800 1660351
    PindololBetapindol (see all 2)13523-86-9targetother/unknown10727715 7944828 2512511 3141589 2664084

    Selected IUPHAR Ligands for HTR1B (5-HT1B receptor) (see all 77)    About this table
    LigandTypeActionAffinityPubmed IDs
    5-HT-moduline
    Allosteric regulatorNegative11.99774213
    oxymetazoline
    AgonistFull agonist9.59632357
    donitriptan
    AgonistFull agonist9.410381763
    [3H]N-methyl-AZ10419369
    AntagonistAntagonist9.419401496
    L-694,247
    AgonistFull agonist9.210513577
    GR-127935
    AntagonistAntagonist9.210513577
    [3H]GR 125,743
    AntagonistAntagonist8.6 - 9.210513577 10452531
    dihydroergotamine
    AgonistFull agonist8 - 9.28863519 8967979
    alniditan
    AgonistFull agonist8.8 - 98967979
    SB 216641
    AgonistPartial agonist99303567

    Selected Novoseek inferred chemical compound relationships for HTR1B gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sumatriptan 88.8 20 17217931 (2), 9871581 (2), 11972574 (2), 11234673 (1) (see all 16)
    sb224289 88.6 3 11972574 (1), 16002749 (1), 17457631 (1)
    naratriptan 86.3 5 10321110 (1), 11152011 (1), 9170336 (1), 10193663 (1) (see all 5)
    5-carboxamidotryptamine 83.6 3 9225278 (1), 14965240 (1), 1559993 (1)
    zolmitriptan 82.6 6 9154322 (1), 9871581 (1), 11152011 (1), 9071266 (1) (see all 6)
    methiothepin 80.8 1 9225276 (1)
    ketanserin 80 7 9225278 (1), 8741180 (1), 9548813 (1), 17521295 (1) (see all 7)
    5-hydroxytryptamine 79.7 52 9384503 (3), 10381763 (2), 18035351 (2), 9723944 (2) (see all 27)
    gr46611 76.2 1 15152026 (1)
    ru 24969 75.7 6 9266609 (2), 1410132 (2), 19013555 (1)



    HTR1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTR1B gene: 
    NM_000863.1  

    Unigene Cluster for HTR1B:

    5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
    Hs.123016  [show with all ESTs]
    Unigene Representative Sequence: AK290080
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369947(uc003pil.1)
    miRNA
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    GenScript: all cDNA clones in your preferred vector: HTR1B (NM_000863)
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      QuantiTect SYBR Green Assays in human, mouse, rat HTR1B
      QuantiFast Probe-based Assays in human, mouse, rat HTR1B

    Additional mRNA sequence: 

    AK290080.1 AK315325.1 BC069065.1 BC096206.1 BC096207.1 BC096208.1 M81590.1 

    1 DOTS entry:

    DT.308845 

    4 AceView cDNA sequences:

    M81590 NM_000863 BC069065 BV198054 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAATGAGG
    HTR1B Expression
    About this image


    HTR1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)
             Metencephalon
    HTR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123016

    UniProtKB/Swiss-Prot: 5HT1B_HUMAN, P28222
    Tissue specificity: Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex,
    striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1B: 
              Neurotransmitter Receptors in human mouse rat
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HTR1B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1b1 , 5 5-hydroxytryptamine (serotonin) receptor 1B1, 5 89.76(n)1
    93.49(a)1
      9 (44.61 cM)5
    155511  NM_010482.11  NP_034612.11 
     816282915 
    chicken
    (Gallus gallus)
    Aves HTR1B1 5-hydroxytryptamine (serotonin) receptor 1B 79.93(n)
    85.15(a)
      421858  NM_001172781.1  NP_001166252.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTR1B6
    5-hydroxytryptamine (serotonin) receptor 1B, G pro...
    81(a)
    1 ↔ 1
    1(200375591-200376766)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004959151 5-hydroxytryptamine receptor 1B-like 68.56(n)
    80.49(a)
      100495915  XM_002936205.2  XP_002936251.2 
    zebrafish
    (Danio rerio)
    Actinopterygii htr1b1 5-hydroxytryptamine (serotonin) receptor 1B 65.52(n)
    66.84(a)
      561647  NM_001128709.1  NP_001122181.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C09B7.1b3
    tyra-21
    tyra-21 32(a)
    (best of 3)3
    49.52(n)1
    42.75(a)1
      X(2709003-2717449)3
    1809701  NM_001029350.41  NP_001024521.11 


    ENSEMBL Gene Tree for HTR1B (if available)
    TreeFam Gene Tree for HTR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTR1B gene
    HTR1A2  ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  
    ADRA1A2  HTR1E2  HTR5A2  ADRA1D2  
    18 SIMAP similar genes for HTR1B using alignment to 1 protein entry:     5HT1B_HUMAN:
    HTR1D    HTR1F    HTR1E    5HT1A    HTR1A    ADRA1D
    ADRA1A    ADRA1B    HTR5A    HTR2A    HTR7    DRD1
    ADRB1    ADRB2    DRD3    HTR2C    ADRB3    HRH2

    HTR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTR1B (see all 156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs581385571,2
    C--78171488(+) GTTCT-/CCCCCCA 1 -- ds50010--------
    rs734692901,2
    C,F--78171519(+) GTCTAG/TTTCAA 1 -- ds50013Minor allele frequency- T:0.12WA 122
    rs1914571151,2
    --78171578(+) AATTAC/GAAGTA 1 -- ds50010--------
    rs1165011401,2
    C,F--78171611(+) CCACGA/GTACCA 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs761948071,2
    C,F--78171615(+) GATACC/AAAAGC 1 -- ds50013Minor allele frequency- A:0.09WA NA EA 358
    rs1449490721,2
    C--78171645(+) ATTATA/CAATTT 1 -- ds50010--------
    rs1831568871,2
    --78171679(+) GATTGG/TCTGCC 1 -- ds50010--------
    rs93612341,2
    C--78171682(+) TGGCTG/ACCGCA 1 -- ds50014Minor allele frequency- A:0.18NA WA EA 360
    rs734692911,2
    C,F--78171717(+) GAGGGG/AAGGAA 1 -- ds50013Minor allele frequency- A:0.09WA CSA 122
    rs1407926481,2
    C--78171782(+) CAGAG-/CTCTCTC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HTR1B (78171948 - 78173490 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HTR1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1975e1CNV Complex17122850
    dgv1974e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HTR1B
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182131    OMIM disorders: --

    Selected diseases for HTR1B (see all 44):    
    About MalaCards
    premature ejaculation    antisocial personality disorder    heroin dependence    personality disorder
    migraine with aura    bulimia nervosa    borderline personality disorder    migraine
    obsessive-compulsive disorder    substance abuse    headache    cluster headache
    substance dependence    attention deficit hyperactivity disorder    alcohol dependence    mood disorder
    alcohol abuse    sleep apnea    spinal cord injury    major depressive disorder

    6 diseases from the University of Copenhagen DISEASES database for HTR1B:
    Antisocial personality disorder     Alcohol dependence     Migraine     Attention deficit hyperactivity disorder
    Intermittent explosive disorder     Borderline personality disorder

    HTR1B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HTR1B gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 69.5 12 9225278 (1), 11735616 (1), 8397171 (1), 17563839 (1) (see all 9)
    attention-deficit hyperactivity disorder 63.1 3 15578613 (1), 16197923 (1), 16958036 (1)
    obsessive-compulsive disorder 54.8 3 17241828 (1), 14731309 (1), 16958036 (1)
    variant angina 47.2 2 16890312 (1), 16960982 (1)
    alcoholism 45 23 19519719 (3), 9819067 (2), 12022963 (2), 11751038 (2) (see all 9)
    aggressive behavior 43.7 4 14730192 (2), 9819067 (1), 12497617 (1)
    psychiatric disorder 35.5 4 19809810 (1), 19921161 (1), 16344719 (1), 16958036 (1)
    coronary spasm 33 3 16890312 (1), 16960982 (1)
    antisocial personality disorder 31.2 3 19519719 (1), 9819067 (1)
    bulimia nervosa 30.1 2 11690602 (2)

    Genetic Association Database (GAD): HTR1B
    Human Genome Epidemiology (HuGE) Navigator: HTR1B (96 documents)

    Export disorders for HTR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTR1B gene, integrated from 10 sources (see all 426):
    (articles sorted by number of sources associating them with HTR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human 5-hydroxytryptamine1B receptor. (PubMed id 1348246)1, 2, 3 Jin H.... O'Dowd B.F. (J. Biol. Chem. 1992)
    2. The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence. (PubMed id 19519719)1, 4, 9 Lee S.Y....Lu R.B. (Alcohol. Clin. Exp. Res. 2009)
    3. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. (PubMed id 19829169)1, 4, 9 Villafuerte S.M....Burmeister M. (Psychiatr. Genet. 2009)
    4. Association study of onset age, attempted suicide, aggressive behavior, and schizophrenia with a serotonin 1B receptor (A-161T) genetic polymorphism. (PubMed id 14730192)1, 4, 9 Hong C.J....Tsai S.J. (Neuropsychobiology 2004)
    5. Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder. (PubMed id 19626271)1, 4, 9 TadiA8 A....Dahmen N. (J Neural Transm 2009)
    6. Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. (PubMed id 16344719)1, 4, 9 Proudnikov D....Kreek M.J. (Pharmacogenet. Genomics 2006)
    7. No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. (PubMed id 15698927)1, 4, 9 Duan S....He L. (Neurosci. Lett. 2005)
    8. Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. (PubMed id 12022963)1, 4, 9 Sun H.F....Cheng A.T. (Biol. Psychiatry 2002)
    9. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. (PubMed id 19350534)1, 4, 9 Conner T.S....Covault J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    10. Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. (PubMed id 17525973)1, 4, 9 Kia-Keating B.M....Tsuang M.T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3351 HGNC: 5287 AceView: HTR1B Ensembl:ENSG00000135312 euGenes: HUgn3351
    ECgene: HTR1B Kegg: 3351 H-InvDB: HTR1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTR1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTR1B gene:
    Search GeneIP for patents involving HTR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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