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Aliases for HTR1B Gene

Aliases for HTR1B Gene

  • 5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled 2 3
  • Serotonin 1D Beta Receptor 3 4
  • Serotonin Receptor 1B 3 4
  • 5-HT-1D-Beta 3 4
  • 5-HT-1B 3 4
  • 5-HT1B 3 4
  • HTR1DB 3 4
  • S12 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1B 2
  • 5-Hydroxytryptamine Receptor 1B 3
  • 5-HT1DB 3
  • HTR1D2 3

External Ids for HTR1B Gene

Previous GeneCards Identifiers for HTR1B Gene

  • GC06M078114
  • GC06M078167
  • GC06M078228
  • GC06M075364
  • GC06M078171

Summaries for HTR1B Gene

Entrez Gene Summary for HTR1B Gene

  • The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]

GeneCards Summary for HTR1B Gene

HTR1B (5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled) is a Protein Coding gene. Diseases associated with HTR1B include antisocial personality disorder and premature ejaculation. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include drug binding and serotonin binding. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1B Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Tocris Summary for HTR1B Gene

  • Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior, aggression, and anxiety. The human 5-HT1B receptor gene has been localized to chromosome 6 (6q13).

Gene Wiki entry for HTR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1B Gene

Genomics for HTR1B Gene

Regulatory Elements for HTR1B Gene

Genomic Location for HTR1B Gene

Start:
77,462,205 bp from pter
End:
77,463,464 bp from pter
Size:
1,260 bases
Orientation:
Minus strand

Genomic View for HTR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1B Gene

Proteins for HTR1B Gene

  • Protein details for HTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28222-5HT1B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1B
    Protein Accession:
    P28222
    Secondary Accessions:
    • Q4VAY7

    Protein attributes for HTR1B Gene

    Size:
    390 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • Homodimer. Heterodimer with HTR1D.
    Miscellaneous:
    • A residue in the 7th transmembrane region (Thr-355 in human, Asn-351 in mouse and rat) is important for species-specific sensitivity to various agonists

    Three dimensional structures from OCA and Proteopedia for HTR1B Gene

neXtProt entry for HTR1B Gene

Proteomics data for HTR1B Gene at MOPED

Post-translational modifications for HTR1B Gene

Other Protein References for HTR1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HTR1B Gene

Domains for HTR1B Gene

Gene Families for HTR1B Gene

HGNC:
  • HTRGP :GPCR / Class A : 5-HT (serotonin) receptors, GPCR only
  • HTR :5-HT (serotonin) receptors
IUPHAR :

Suggested Antigen Peptide Sequences for HTR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28222

UniProtKB/Swiss-Prot:

5HT1B_HUMAN :
  • P28222
Domain:
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1B: view

Function for HTR1B Gene

Molecular function for HTR1B Gene

GENATLAS Biochemistry: 5-hydroxytryptamine (serotonin) receptor,subtype 1D beta,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Gene Ontology (GO) - Molecular Function for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004993 serotonin receptor activity IDA 1315531
GO:0005515 protein binding IPI 25416956
GO:0008144 drug binding IEA --
GO:0051378 serotonin binding IEA --
genes like me logo Genes that share ontologies with HTR1B: view
genes like me logo Genes that share phenotypes with HTR1B: view

Animal Models for HTR1B Gene

MGI Knock Outs for HTR1B:

miRNA for HTR1B Gene

miRTarBase miRNAs that target HTR1B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HTR1B Gene

Localization for HTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1B Gene COMPARTMENTS Subcellular localization image for HTR1B gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 1315531
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HTR1B: view

Pathways for HTR1B Gene

genes like me logo Genes that share pathways with HTR1B: view

Pathways by source for HTR1B Gene

Gene Ontology (GO) - Biological Process for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1559993
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 1315531
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HTR1B: view

Compounds for HTR1B Gene

(5) Tocris Compounds for HTR1B Gene

Compound Action Cas Number
CP 93129 dihydrochloride 5-HT1B agonist [879089-64-2]
CP 94253 hydrochloride Potent, selective 5-HT1B agonist [845861-39-4]
GR 55562 dihydrochloride 5-HT1B antagonist [159533-25-2]
SB 216641 hydrochloride Selective h5-HT1B antagonist [193611-67-5]
SB 224289 hydrochloride Selective 5-HT1B antagonist [180084-26-8]

(4) HMDB Compounds for HTR1B Gene

Compound Synonyms Cas Number PubMed IDs
Propranolol
  • Dociton
525-66-6
Serotonin
  • 3-(2-Aminoethyl)-1H-indol-5-ol
50-67-9
Sumatriptan
  • Imigran
103628-46-2
Venlafaxine
  • Efectin
93413-69-5

(27) Drugbank Compounds for HTR1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Almotriptan
181183-52-8 target agonist
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Aripiprazole
  • OPC 31
129722-12-9 target antagonist
Asenapine
65576-45-6 target antagonist
Bopindolol
69010-88-4 target

(77) IUPHAR Ligand for HTR1B Gene

Ligand Type Action Affinity Pubmed IDs
5-HT-moduline Allosteric regulator Negative 12
asenapine Antagonist Antagonist 9.8
S33084 Antagonist Antagonist 9.6
[3H]N-methyl-AZ10419369 Antagonist Antagonist 9.4
alniditan Agonist Full agonist 9.4
[3H]8-OH-DPAT Agonist Full agonist 9.4
methiothepin Antagonist Antagonist 9.4
8-OH-DPAT Agonist Full agonist 9.4
L-694,247 Agonist Full agonist 9.3
zotepine Antagonist Antagonist 9.2
olanzapine Antagonist Antagonist 9.2
SL65.0155 Agonist Partial agonist 9.2
[3H]eletriptan Agonist Full agonist 9.1
[3H]alniditan Agonist Full agonist 8.92
terguride Antagonist Antagonist 8.9
CP94253 Agonist Full agonist 8.7
[3H]GR 125,743 Antagonist Antagonist 8.6
7-methoxy-1-naphthylpiperazine Agonist Full agonist 8.6
SB 649915 Antagonist Antagonist 8.6
roxindole Antagonist Antagonist 8.6
rauwolscine Antagonist Antagonist 8.4
SB236057 Antagonist Inverse agonist 8.2
5-(nonyloxy)-tryptamine Agonist Full agonist 8.2
[3H]sumatriptan Agonist Full agonist 8.2
BMS 181,101 Agonist Partial agonist 8.1
SB 272183 Antagonist Antagonist 8
1-naphthylpiperazine Agonist Full agonist 8
ocaperidone Agonist Full agonist 8
ziprasidone Antagonist Antagonist 7.8
risperidone Antagonist Antagonist 7.8
CP-122288 Agonist Full agonist 7.7
naratriptan Agonist Full agonist 7.6
(+)-WAY 100135 Antagonist Antagonist 7.6
GR-55562 Antagonist Antagonist 7.5
9-OH-risperidone Antagonist Antagonist 7.5
(S)-flurocarazolol Antagonist Antagonist 7.5
aripiprazole Antagonist Antagonist 7.5
lysergol Agonist Full agonist 7.4
eletriptan Agonist Full agonist 7.4
metergoline Antagonist Antagonist 7.4
ritanserin Antagonist Antagonist 7.4
yohimbine Antagonist Antagonist 7.3
lisuride Agonist Partial agonist 7.2
L-772,405 Agonist Full agonist 7.2
tryptamine Agonist Full agonist 7.2
dihydroergotamine Agonist Full agonist 7.1
sertindole Antagonist Antagonist 6.9
L-775,606 Agonist Partial agonist 6.9
oxymetazoline Agonist Full agonist 6.8
methysergide Antagonist Antagonist 6.8
5-MeOT Agonist Full agonist 6.8
cabergoline Agonist Full agonist 6.7
clozapine Antagonist Antagonist 6.7
zolmitriptan Agonist Full agonist 6.6
SB 714786 Antagonist Antagonist 6.5
pergolide Agonist Full agonist 6.5
(R)-flurocarazolol Antagonist Antagonist 6.5
TFMPP Agonist Full agonist 6.4
rizatriptan Agonist Full agonist 6.4
2-methyl-5-HT Agonist Full agonist 6.4
SB 216641 Agonist Partial agonist 6.3
LY344864 Agonist Full agonist 6.3
ketanserin Inhibitor Inhibition 6.3
RU 24969 Agonist Full agonist 6.2
bromocriptine Agonist Partial agonist 6.2
5-CT Agonist Full agonist 6.1
xanomeline Agonist Full agonist 5.9
BRL-15572 Agonist Partial agonist 5.9
GR-127935 Agonist Partial agonist 5.8
dipropyl-5-CT Agonist Full agonist 5.8
SB 224289 Antagonist Antagonist 5.7
donitriptan Agonist Partial agonist 5.6
CGS-12066 Agonist Full agonist 5.6
sumatriptan Antagonist Antagonist 5.6
pipamperone Antagonist Antagonist 5.6
5-HT Inhibitor Inhibition 2.2
[11C]AZ10419369 None None

(48) Novoseek inferred chemical compound relationships for HTR1B Gene

Compound -log(P) Hits PubMed IDs
sumatriptan 88.8 19
sb224289 88.6 3
naratriptan 86.3 5
5-carboxamidotryptamine 83.6 3
zolmitriptan 82.6 6

(6) PharmGKB related drug/compound annotations for HTR1B Gene

Drug/compound Annotation
clomipramine CA
liothyronine CA
lithium CA
nefazodone CA
paroxetine CA
venlafaxine CA
genes like me logo Genes that share compounds with HTR1B: view

Transcripts for HTR1B Gene

mRNA/cDNA for HTR1B Gene

(4) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1B Gene

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1B Gene

No ASD Table

Relevant External Links for HTR1B Gene

GeneLoc Exon Structure for
HTR1B
ECgene alternative splicing isoforms for
HTR1B

Expression for HTR1B Gene

mRNA expression in normal human tissues for HTR1B Gene

mRNA differential expression in normal tissues according to GTEx for HTR1B Gene

This gene is overexpressed in Artery - Tibial (9.1), Artery - Coronary (6.7), and Artery - Aorta (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTR1B Gene

SOURCE GeneReport for Unigene cluster for HTR1B Gene Hs.123016

mRNA Expression by UniProt/SwissProt for HTR1B Gene

P28222-5HT1B_HUMAN
Tissue specificity: Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
genes like me logo Genes that share expressions with HTR1B: view

Orthologs for HTR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTR1B 35
  • 99.66 (n)
  • 100 (a)
HTR1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTR1B 35
  • 89.6 (n)
  • 90.46 (a)
HTR1B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1B 35
  • 92.03 (n)
  • 96.24 (a)
mouse
(Mus musculus)
Mammalia Htr1b 35
  • 89.76 (n)
  • 93.49 (a)
Htr1b 16
Htr1b 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTR1B 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1b 35
  • 89.72 (n)
  • 93.78 (a)
chicken
(Gallus gallus)
Aves HTR1B 35
  • 79.93 (n)
  • 85.15 (a)
HTR1B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1B 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495915 35
  • 68.56 (n)
  • 80.49 (a)
zebrafish
(Danio rerio)
Actinopterygii htr1b 35
  • 65.52 (n)
  • 66.84 (a)
htr1b 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 44 (a)
5-HT1B 37
  • 42 (a)
CG7431 37
  • 36 (a)
5-HT7 37
  • 36 (a)
DopR2 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea tyra-2 35
  • 49.52 (n)
  • 42.75 (a)
C09B7.1b 37
  • 32 (a)
C09B7.1a 37
  • 32 (a)
F14D12.6 37
  • 32 (a)
Species with no ortholog for HTR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1B Gene

ENSEMBL:
Gene Tree for HTR1B (if available)
TreeFam:
Gene Tree for HTR1B (if available)

Paralogs for HTR1B Gene

Paralogs for HTR1B Gene

Selected SIMAP similar genes for HTR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1B: view

Variants for HTR1B Gene

Sequence variations from dbSNP and Humsavar for HTR1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6296 -- 77,462,543(-) TATGT(C/G)AACCA synonymous-codon, reference
rs6297 -- 77,462,224(-) TTGCC(A/G)TTTGC downstream-variant-500B
rs6298 -- 77,463,275(-) GACTC(C/T)ATCTC reference, synonymous-codon
rs130056 -- 77,463,914(-) GGTGG(G/T)AATGC upstream-variant-2KB
rs130057 -- 77,463,584(-) GCCCG(-/CC)TGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HTR1B Gene

Variant ID Type Subtype PubMed ID
dgv1974e1 CNV Complex 17122850
dgv1975e1 CNV Complex 17122850

Relevant External Links for HTR1B Gene

HapMap Linkage Disequilibrium report
HTR1B
Human Gene Mutation Database (HGMD)
HTR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1B Gene

Disorders for HTR1B Gene

(18) Novoseek inferred disease relationships for HTR1B Gene

Disease -log(P) Hits PubMed IDs
migraine 69.5 9
attention-deficit hyperactivity disorder 63.1 3
obsessive-compulsive disorder 54.8 3
variant angina 47.2 2
alcoholism 45 14

Relevant External Links for HTR1B

Genetic Association Database (GAD)
HTR1B
Human Genome Epidemiology (HuGE) Navigator
HTR1B
genes like me logo Genes that share disorders with HTR1B: view

No data available for UniProtKB/Swiss-Prot for HTR1B Gene

Publications for HTR1B Gene

  1. Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. (PMID: 8218242) Ng G.Y.K. … O'Dowd B.F. (Biochemistry 1993) 3 4 23
  2. Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. (PMID: 1559993) Levy F.O. … Birnbaumer L. (J. Biol. Chem. 1992) 3 4 23
  3. Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. (PMID: 11247661) Sanders A.R. … Gejman P.V. (Genomics 2001) 2 3 23
  4. Polymorphism of the serotonin 5-HT1B receptor gene (HTR1B) associated with minimum lifetime body mass index in women with bulimia nervosa. (PMID: 11690602) Levitan R.D. … Kennedy J.L. (Biol. Psychiatry 2001) 3 23 48
  5. Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence. (PMID: 11751038) Kranzler H.R. … Gelernter J. (Neuropsychopharmacology 2002) 3 23 48

Products for HTR1B Gene

Sources for HTR1B Gene

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