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Aliases for HTR1B Gene

Aliases for HTR1B Gene

  • 5-Hydroxytryptamine Receptor 1B 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1B, G Protein-Coupled 2 3 5
  • Serotonin 1D Beta Receptor 3 4
  • Serotonin Receptor 1B 3 4
  • 5-HT-1D-Beta 3 4
  • 5-HT-1B 3 4
  • 5-HT1B 3 4
  • HTR1DB 3 4
  • S12 3 4
  • 5-Hydroxytryptamine (Serotonin) Receptor 1B 2
  • 5-HT1DB 3
  • HTR1D2 3

External Ids for HTR1B Gene

Previous GeneCards Identifiers for HTR1B Gene

  • GC06M078114
  • GC06M078167
  • GC06M078228
  • GC06M075364
  • GC06M078171

Summaries for HTR1B Gene

Entrez Gene Summary for HTR1B Gene

  • The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

GeneCards Summary for HTR1B Gene

HTR1B (5-Hydroxytryptamine Receptor 1B) is a Protein Coding gene. Diseases associated with HTR1B include prinzmetal's variant angina and personality disorder. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1B Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Tocris Summary for HTR1B Gene

  • Serotonin 5-HT1B receptors, previously known as 5-HT1D receptors, are primarily located in the basal ganglia, striatum, hippocampus and vascular smooth muscle. 5-HT1B receptors play a role in thermoregulation, respiration, appetite control, sexual behavior and aggression.

Gene Wiki entry for HTR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1B Gene

Genomics for HTR1B Gene

Regulatory Elements for HTR1B Gene

Promoters for HTR1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HTR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR1B Gene

Chromosome:
6
Start:
77,462,205 bp from pter
End:
77,463,464 bp from pter
Size:
1,260 bases
Orientation:
Minus strand

Genomic View for HTR1B Gene

Genes around HTR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1B Gene

Proteins for HTR1B Gene

  • Protein details for HTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28222-5HT1B_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1B
    Protein Accession:
    P28222
    Secondary Accessions:
    • Q4VAY7

    Protein attributes for HTR1B Gene

    Size:
    390 amino acids
    Molecular mass:
    43568 Da
    Quaternary structure:
    • Homodimer. Heterodimer with HTR1D.
    Miscellaneous:
    • A residue in the 7th transmembrane region (Thr-355 in human, Asn-351 in mouse and rat) is important for species-specific sensitivity to various agonists.

    Three dimensional structures from OCA and Proteopedia for HTR1B Gene

neXtProt entry for HTR1B Gene

Proteomics data for HTR1B Gene at MOPED

Post-translational modifications for HTR1B Gene

Other Protein References for HTR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HTR1B Gene

Domains & Families for HTR1B Gene

Suggested Antigen Peptide Sequences for HTR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28222

UniProtKB/Swiss-Prot:

5HT1B_HUMAN :
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
  • Belongs to the G-protein coupled receptor 1 family.
Domain:
  • Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HTR1B: view

Function for HTR1B Gene

Molecular function for HTR1B Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype 1D beta,expressed in brain cortex,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
genes like me logo Genes that share phenotypes with HTR1B: view

Animal Models for HTR1B Gene

MGI Knock Outs for HTR1B:

Animal Model Products

miRNA for HTR1B Gene

miRTarBase miRNAs that target HTR1B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTR1B Gene

Localization for HTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1B Gene COMPARTMENTS Subcellular localization image for HTR1B gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for HTR1B Gene

Pathways & Interactions for HTR1B Gene

genes like me logo Genes that share pathways with HTR1B: view

Gene Ontology (GO) - Biological Process for HTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002031 G-protein coupled receptor internalization IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 1315531
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission IEA --
genes like me logo Genes that share ontologies with HTR1B: view

No data available for SIGNOR curated interactions for HTR1B Gene

Drugs & Compounds for HTR1B Gene

(155) Drugs for HTR1B Gene - From: Novoseek, ApexBio, DrugBank, HMDB, IUPHAR, DGIdb, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naratriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 14
Zolmitriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target Potent 5-HT1B/1D/1F agonist 16
Dihydroergotamine Approved Pharma Full agonist, Agonist, agonist, Target 10
Rizatriptan Approved Pharma Full agonist, Agonist, agonist, Target 35
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist, agonist, Target 97

(21) Additional Compounds for HTR1B Gene - From: Novoseek, IUPHAR, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(R)-flurocarazolol
Antagonist
(S)-flurocarazolol
Antagonist
5-HT
Full agonist, Agonist
N-Desmethyleletriptan
5-Nonyloxytryptamine oxalate
157798-13-5
genes like me logo Genes that share compounds with HTR1B: view

Drug Products

Transcripts for HTR1B Gene

mRNA/cDNA for HTR1B Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1B Gene

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1B Gene

No ASD Table

Relevant External Links for HTR1B Gene

GeneLoc Exon Structure for
HTR1B
ECgene alternative splicing isoforms for
HTR1B

Expression for HTR1B Gene

mRNA expression in normal human tissues for HTR1B Gene

mRNA differential expression in normal tissues according to GTEx for HTR1B Gene

This gene is overexpressed in Artery - Tibial (x9.1), Artery - Coronary (x6.7), and Artery - Aorta (x5.7).

Protein differential expression in normal tissues from HIPED for HTR1B Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1B Gene



SOURCE GeneReport for Unigene cluster for HTR1B Gene Hs.123016

mRNA Expression by UniProt/SwissProt for HTR1B Gene

P28222-5HT1B_HUMAN
Tissue specificity: Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
genes like me logo Genes that share expression patterns with HTR1B: view

Protein tissue co-expression partners for HTR1B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HTR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1B 35
  • 89.6 (n)
  • 90.46 (a)
HTR1B 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1B 35
  • 92.03 (n)
  • 96.24 (a)
mouse
(Mus musculus)
Mammalia Htr1b 35
  • 89.76 (n)
  • 93.49 (a)
Htr1b 16
Htr1b 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1B 35
  • 99.66 (n)
  • 100 (a)
HTR1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1b 35
  • 89.72 (n)
  • 93.78 (a)
oppossum
(Monodelphis domestica)
Mammalia HTR1B 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1B 35
  • 79.93 (n)
  • 85.15 (a)
HTR1B 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTR1B 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495915 35
  • 68.56 (n)
  • 80.49 (a)
zebrafish
(Danio rerio)
Actinopterygii htr1b 35
  • 65.52 (n)
  • 66.84 (a)
htr1b 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 44 (a)
5-HT1B 37
  • 42 (a)
5-HT7 37
  • 36 (a)
CG7431 37
  • 36 (a)
DopR2 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea C09B7.1a 37
  • 32 (a)
C09B7.1b 37
  • 32 (a)
F14D12.6 37
  • 32 (a)
tyra-2 35
  • 49.52 (n)
  • 42.75 (a)
Species with no ortholog for HTR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1B Gene

ENSEMBL:
Gene Tree for HTR1B (if available)
TreeFam:
Gene Tree for HTR1B (if available)

Paralogs for HTR1B Gene

(18) SIMAP similar genes for HTR1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTR1B: view

Variants for HTR1B Gene

Sequence variations from dbSNP and Humsavar for HTR1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_011715 -
VAR_011831 -
VAR_011832 -
VAR_011833 -

Structural Variations from Database of Genomic Variants (DGV) for HTR1B Gene

Variant ID Type Subtype PubMed ID
dgv1974e1 CNV Complex 17122850
dgv1975e1 CNV Complex 17122850

Variation tolerance for HTR1B Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1B Gene

HapMap Linkage Disequilibrium report
HTR1B
Human Gene Mutation Database (HGMD)
HTR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1B Gene

Disorders for HTR1B Gene

MalaCards: The human disease database

(17) MalaCards diseases for HTR1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prinzmetal's variant angina
  • prinzmetal angina
personality disorder
  • character disorder
migraine with or without aura 1
  • migraine
obsessive-compulsive disorder
  • obsessive-compulsive disorder, protection against
premature ejaculation
- elite association - COSMIC cancer census association via MalaCards
Search HTR1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTR1B

Genetic Association Database (GAD)
HTR1B
Human Genome Epidemiology (HuGE) Navigator
HTR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1B
genes like me logo Genes that share disorders with HTR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTR1B Gene

Publications for HTR1B Gene

  1. Characterization of the human 5-hydroxytryptamine1B receptor. (PMID: 1348246) Jin H. … O'Dowd B.F. (J. Biol. Chem. 1992) 2 3 4 67
  2. Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine. (PMID: 15311727) Balbisi E.A. (Int. J. Clin. Pract. 2004) 23 25 26
  3. Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan. (PMID: 12028320) Comer M.B. (Headache 2002) 23 25 26
  4. Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. (PMID: 11247661) Sanders A.R. … Gejman P.V. (Genomics 2001) 2 3 23
  5. Frovatriptan. (PMID: 11735616) Easthope S.E. … Goa K.L. (CNS Drugs 2001) 23 25 26

Products for HTR1B Gene

Sources for HTR1B Gene

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