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Aliases for HTR1A Gene

Aliases for HTR1A Gene

  • 5-Hydroxytryptamine Receptor 1A 2 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled 2 3 5
  • ADRB2RL1 3 4
  • ADRBRL1 3 4
  • 5-HT-1A 3 4
  • 5-HT1A 3 4
  • G-21 3 4
  • Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor 3
  • 5-Hydroxytryptamine (Serotonin) Receptor 1A 2
  • Serotonin Receptor 1A 4
  • 5-HT1a Receptor 3
  • 5HT1a 3
  • PFMCD 3

External Ids for HTR1A Gene

Previous HGNC Symbols for HTR1A Gene

  • ADRB2RL1
  • ADRBRL1

Previous GeneCards Identifiers for HTR1A Gene

  • GC05M063417
  • GC05M064794
  • GC05M063226
  • GC05M063272
  • GC05M063292
  • GC05M060210

Summaries for HTR1A Gene

Entrez Gene Summary for HTR1A Gene

  • This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

GeneCards Summary for HTR1A Gene

HTR1A (5-Hydroxytryptamine Receptor 1A) is a Protein Coding gene. Diseases associated with HTR1A include periodic fever, menstrual cycle dependent and generalized anxiety disorder. Among its related pathways are cAMP signaling pathway and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled serotonin receptor activity. An important paralog of this gene is HTR1F.

UniProtKB/Swiss-Prot for HTR1A Gene

  • G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Tocris Summary for HTR1A Gene

  • The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced. 5-HT1A receptor binding sites are located primarily in limbic brain areas, notably the hypothalamus and cortical areas. The human gene encoding this receptor has been localized to chromosome 5.

Gene Wiki entry for HTR1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTR1A Gene

Genomics for HTR1A Gene

Regulatory Elements for HTR1A Gene

Enhancers for HTR1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTR1A on UCSC Golden Path with GeneCards custom track

Genomic Location for HTR1A Gene

Chromosome:
5
Start:
63,960,048 bp from pter
End:
63,962,507 bp from pter
Size:
2,460 bases
Orientation:
Minus strand

Genomic View for HTR1A Gene

Genes around HTR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTR1A Gene

Proteins for HTR1A Gene

  • Protein details for HTR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08908-5HT1A_HUMAN
    Recommended name:
    5-hydroxytryptamine receptor 1A
    Protein Accession:
    P08908
    Secondary Accessions:
    • Q6LAE7

    Protein attributes for HTR1A Gene

    Size:
    422 amino acids
    Molecular mass:
    46107 Da
    Quaternary structure:
    • Heterodimer; heterodimerizes with GPER1.

neXtProt entry for HTR1A Gene

Proteomics data for HTR1A Gene at MOPED

Post-translational modifications for HTR1A Gene

  • Ubiquitination at Lys 334
  • Glycosylation at Asn 10, Asn 11, and Asn 24
  • Modification sites at PhosphoSitePlus

Other Protein References for HTR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTR1A (5-HT(1A))

No data available for DME Specific Peptides for HTR1A Gene

Domains & Families for HTR1A Gene

Suggested Antigen Peptide Sequences for HTR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08908

UniProtKB/Swiss-Prot:

5HT1A_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
genes like me logo Genes that share domains with HTR1A: view

Function for HTR1A Gene

Molecular function for HTR1A Gene

GENATLAS Biochemistry:
5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate cyclase
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Gene Ontology (GO) - Molecular Function for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 22035699
genes like me logo Genes that share ontologies with HTR1A: view
genes like me logo Genes that share phenotypes with HTR1A: view

Human Phenotype Ontology for HTR1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HTR1A Gene

MGI Knock Outs for HTR1A:

Animal Model Products

miRNA for HTR1A Gene

miRTarBase miRNAs that target HTR1A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HTR1A Gene

Localization for HTR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTR1A Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTR1A Gene COMPARTMENTS Subcellular localization image for HTR1A gene
Compartment Confidence
plasma membrane 5
extracellular 3
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HTR1A Gene

Pathways & Interactions for HTR1A Gene

genes like me logo Genes that share pathways with HTR1A: view

Gene Ontology (GO) - Biological Process for HTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response ISS --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IMP 22957663
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 8393041
GO:0008284 positive regulation of cell proliferation TAS 1330092
GO:0035640 exploration behavior IEA,ISS --
genes like me logo Genes that share ontologies with HTR1A: view

No data available for SIGNOR curated interactions for HTR1A Gene

Drugs & Compounds for HTR1A Gene

(216) Drugs for HTR1A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aripiprazole Approved, Investigational Pharma Antagonist, agonist, Target, antagonist, partial agonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 343
Lisuride Approved Pharma Antagonist, agonist, Target 5
Clozapine Approved Pharma Antagonist, antagonist, Target Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Buspirone Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target, partial agonist 45

(52) Additional Compounds for HTR1A Gene - From: IUPHAR, Tocris, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-quinpirole
Full agonist, Agonist
(+)-flesinoxan
Full agonist, Agonist
(R)-flurocarazolol
Antagonist
(S)-flurocarazolol
Antagonist
[<sup>3</sup>H]NAD 299
Antagonist

(5) Tocris Compounds for HTR1A Gene

Compound Action Cas Number
8-Hydroxy-DPAT hydrobromide Selective 5-HT1A agonist; also has moderate affinity for 5-HT7 76135-31-4
8-Hydroxy-PIPAT oxalate High affinity 5-HT1A agonist 1451210-48-2
BP 554 maleate Selective 5-HT1A agonist 1221401-95-1
MDL 73005EF hydrochloride Potent and selective 5-HT1A partial agonist 102908-60-1
RU 24969 hemisuccinate 5-HT1B/1A agonist 66611-27-6

(7) ApexBio Compounds for HTR1A Gene

Compound Action Cas Number
BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist 21102-95-4
Buspirone HCl 33386-08-2
Flopropione 2295-58-1
Lurasidone HCl Dopamine D2/5-HT2A/5-HT7/5-HT1A inhibitor 367514-88-3
Sumatriptan Succinate 5-HT1 receptor agonist 103628-48-4
Vilazodone Hydrochloride Combined SSRI and 5-HT1A receptor partial agonist 163521-08-2
WAY-100635 Maleate 5-HT1A receptor agonist 1092679-51-0
genes like me logo Genes that share compounds with HTR1A: view

Drug Products

Transcripts for HTR1A Gene

mRNA/cDNA for HTR1A Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HTR1A Gene

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTR1A Gene

No ASD Table

Relevant External Links for HTR1A Gene

GeneLoc Exon Structure for
HTR1A
ECgene alternative splicing isoforms for
HTR1A

Expression for HTR1A Gene

mRNA expression in normal human tissues for HTR1A Gene

mRNA differential expression in normal tissues according to GTEx for HTR1A Gene

This gene is overexpressed in Brain - Hippocampus (x13.8), Brain - Frontal Cortex (BA9) (x9.7), Brain - Cortex (x8.9), Brain - Anterior cingulate cortex (BA24) (x7.2), and Brain - Amygdala (x4.4).

Protein differential expression in normal tissues from HIPED for HTR1A Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTR1A Gene



SOURCE GeneReport for Unigene cluster for HTR1A Gene Hs.247940

mRNA Expression by UniProt/SwissProt for HTR1A Gene

P08908-5HT1A_HUMAN
Tissue specificity: Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
genes like me logo Genes that share expression patterns with HTR1A: view

Protein tissue co-expression partners for HTR1A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for HTR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for HTR1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTR1A 35
  • 88.31 (n)
  • 91.71 (a)
5HTR1A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTR1A 35
  • 89.1 (n)
  • 91.71 (a)
HTR1A 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htr1a 35
  • 85.59 (n)
  • 88.36 (a)
Htr1a 16
Htr1a 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTR1A 35
  • 99.68 (n)
  • 99.29 (a)
HTR1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htr1a 35
  • 85.47 (n)
  • 89.81 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HTR1A 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTR1A 35
  • 77.64 (n)
  • 83.17 (a)
HTR1A 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htr1a 35
  • 70.29 (n)
  • 77.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia htr1a-A 35
zebrafish
(Danio rerio)
Actinopterygii htr1aa 35
  • 71.33 (n)
  • 79.39 (a)
htr1ab 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta 5-HT1A 37
  • 47 (a)
5-HT1B 37
  • 49 (a)
5-HT7 37
  • 39 (a)
CG7431 37
  • 42 (a)
DopR2 37
  • 45 (a)
5-HT1A 35
  • 58.61 (n)
  • 49.82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPR5HT1A 35
  • 56.36 (n)
  • 47.58 (a)
worm
(Caenorhabditis elegans)
Secernentea F14D12.6 37
  • 30 (a)
ser-4 35
  • 47.53 (n)
  • 42.86 (a)
Species with no ortholog for HTR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTR1A Gene

ENSEMBL:
Gene Tree for HTR1A (if available)
TreeFam:
Gene Tree for HTR1A (if available)

Paralogs for HTR1A Gene

(19) SIMAP similar genes for HTR1A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTR1A: view

Variants for HTR1A Gene

Sequence variations from dbSNP and Humsavar for HTR1A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1800041 - 63,961,673(-) ACCAC(C/T)GGCTC reference, missense
rs1799920 - 63,961,656(-) AGACC(A/C/G)GCGGC reference, missense
rs1799921 - 63,961,638(-) CTGGT(A/G)TCTCC reference, missense
rs1800043 - 63,961,169(-) GGACC(C/T)CGACG reference, missense
rs1800044 - 63,961,061(-) ATTCC(G/T)AGCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HTR1A Gene

Variant ID Type Subtype PubMed ID
nsv4860 CNV Insertion 18451855

Variation tolerance for HTR1A Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTR1A Gene

HapMap Linkage Disequilibrium report
HTR1A
Human Gene Mutation Database (HGMD)
HTR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTR1A Gene

Disorders for HTR1A Gene

MalaCards: The human disease database

(49) MalaCards diseases for HTR1A Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
periodic fever, menstrual cycle dependent
  • periodic fever, menstrual cycle-dependent
generalized anxiety disorder
  • anxiety generalized
agoraphobia
  • fear of open spaces
anxiety disorder
  • anxiety state
serotonin syndrome
  • serotonergic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HTR1A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

5HT1A_HUMAN
  • Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269 PubMed:21990073}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HTR1A

Genetic Association Database (GAD)
HTR1A
Human Genome Epidemiology (HuGE) Navigator
HTR1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTR1A
genes like me logo Genes that share disorders with HTR1A: view

No data available for Genatlas for HTR1A Gene

Publications for HTR1A Gene

  1. Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. (PMID: 9754630) Kawanishi Y. … Shiraishi H. (Am. J. Med. Genet. 1998) 3 4 48 67
  2. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. (PMID: 15888508) Odagaki Y. … Yamauchi T. (J. Psychopharmacol. (Oxford) 2005) 23 25 26
  3. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. (PMID: 15257633) Swainston Harrison T. … Perry C.M. (Drugs 2004) 23 25 26
  4. The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice. (PMID: 14728084) Stahl S.M. … Shayegan D.K. (J Clin Psychiatry 2003) 23 25 26
  5. The anxiolytic effect of the novel antipsychotic ziprasidone compared with diazepam in subjects anxious before dental surgery. (PMID: 11910268) Wilner K.D. … Titus C.K. (J Clin Psychopharmacol 2002) 23 25 26

Products for HTR1A Gene

Sources for HTR1A Gene

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