Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HTR1A Gene

protein-coding   GIFtS: 68
GCID: GC05M063292

5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1A)
(Previous symbols: ADRB2RL1, ADRBRL1)
  See HTR1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled1 2     5-Hydroxytryptamine (Serotonin) Receptor 1A1
ADRB2RL11 2 3 5     5-HT1a Receptor2
ADRBRL11 2 3     5-Hydroxytryptamine Receptor 1A2
5-HT-1A2 3     5HT1a2
5-HT1A2 3     Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor2
G-212 3     Serotonin Receptor 1A3
PFMCD2 5     

External Ids:    HGNC: 52861   Entrez Gene: 33502   Ensembl: ENSG000001783947   OMIM: 1097605   UniProtKB: P089083   

Export aliases for HTR1A gene to outside databases

Previous GC identifers: GC05M063417 GC05M064794 GC05M063226 GC05M063272 GC05M060210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HTR1A Gene:
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the
5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and
pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety
and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent
periodic fevers. (provided by RefSeq, Jun 2012)

GeneCards Summary for HTR1A Gene:
HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1A include agoraphobia, and periodic fever, menstrual cycle dependent. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is ADRA1B.

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of
alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a
phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular
stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and
5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the
brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli

summary for HTR1A Gene:
The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced and the human gene encoding
this receptor has been localized on chromosome 5 (5q11.2-q13). 5-HT1A receptor binding sites are located
primarily in limbic brain areas, notably the hypothalamus, lateral septum, cortical areas and the
mesencephalic raphe nuclei. 5-HT1A receptor ligands with agonist activity possess antianxiety,
antidepressant, antiaggressive, and perhaps anticraving, anticataleptic, antiemetic, and neuroprotective
properties.

Gene Wiki entry for HTR1A (5-HT1A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTR1A gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1A promoter sequence
   Search Chromatin IP Primers for HTR1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q11.2-q13

HTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M063292:  view genomic region     (about GC identifiers)

Start:
63,256,183 bp from pter      End:
63,258,334 bp from pter
Size:
2,152 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1A  
Size: 422 amino acids; 46107 Da
Subunit: Heterodimer; heterodimerizes with GPER1
Secondary accessions: Q6LAE7

Explore the universe of human proteins at neXtProt for HTR1A: NX_P08908

Explore proteomics data for HTR1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys334
  • Glycosylation2 at Asn10, Asn11, Asn24
  • Modification sites at PhosphoSitePlus

  • See HTR1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000515.2  
    ENSEMBL proteins: 
     ENSP00000423433   ENSP00000316244  
    Reactome Protein details: P08908

    HTR1A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HTR1A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HTR1A
    GenScript Custom Purified and Recombinant Proteins Services for HTR1A
    Novus Biologicals HTR1A Proteins
    Novus Biologicals HTR1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR1A

     
    Search eBioscience for Proteins for HTR1A 

     
    antibodies-online proteins for HTR1A (6 products) 

     
    antibodies-online peptides for HTR1A

    HTR1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HTR1A
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HTR1A  (5-HT(1A))
    OriGene Antibodies for HTR1A
    OriGene Custom Antibody Services for HTR1A
    Novus Biologicals HTR1A Antibodies
    Abcam antibodies for HTR1A
    Cloud-Clone Corp. Antibodies for HTR1A
    ThermoFisher Antibodies for HTR1A
    antibodies-online antibodies for HTR1A (46 products) 

    HTR1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HTR1A
    Browse R&D Systems for biochemical assays
    GenScript HTR1A-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTR1A
    Cloud-Clone Corp. CLIAs for HTR1A
    Search eBioscience for ELISAs for HTR1A 
    antibodies-online kits for HTR1A (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1A receptor
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR000610 5HT1A_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08908

    ProtoNet protein and cluster: P08908

    2 Blocks protein domains:
    IPB000610 5-hydroxytryptamine 1A receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
    Similarity: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A
    sub-subfamily


    Find genes that share domains with HTR1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1A_HUMAN, P08908
    Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various
    drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via
    guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as
    adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of
    alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a
    phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular
    stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and
    5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the
    brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli

         Genatlas biochemistry entry for HTR1A:
    5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate
    cyclase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IMP--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with HTR1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR1A:
     Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Htr1a):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 
     no phenotypic analysis 

    Find genes that share phenotypes with HTR1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HTR1A: Htr1atm2Rhn Htr1atm1Toth Htr1atm1Rhn Htr1atm3Rhn Htr1atm1Tct

       genOway: Develop your customized and physiologically relevant rodent model for HTR1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target HTR1A:
    hsa-mir-335-5p (MIRT018705)

    Block miRNA regulation of human, mouse, rat HTR1A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HTR1A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTR1A
    Predesigned siRNA for gene silencing in human, mouse, rat HTR1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTR1A

    Clone
    Products:
         
    OriGene clones in human, mouse for HTR1A (see all 5)
    OriGene ORF clones in mouse, rat for HTR1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTR1A (NM_000524)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1A
    Addgene plasmids for HTR1A 

    Cell Line
    Products:
         
    GenScript HTR1A-overexpressing Cell Line for Assay
    Browse ESI BIO Cell Lines and PureStem Progenitors for HTR1A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    5HT1A_HUMAN, P08908: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with HTR1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HTR1A About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.00
    Amine ligand-binding receptors0.79
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33


    Find genes that share SuperPaths with HTR1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HTR1A
        Intracellular Calcium Signaling

    2 Cell Signaling Technology (CST) Pathways for HTR1A
        Ca, cAMP and Lipid Signaling
    Neuroscience

    3 BioSystems Pathways for HTR1A
        SIDS Susceptibility Pathways
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    2 Reactome Pathways for HTR1A
        Serotonin receptors
    G alpha (i) signalling events

    1 PharmGKB Pathway for HTR1A
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for HTR1A):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTR1A (P089081, 3 ENSP000003162444) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI3P087543, ENSP000003588674I2D: score=1 STRING: ENSP00000358867
    HTR1BP282223, ENSP000003589634I2D: score=2 STRING: ENSP00000358963
    HTR1DP282213, ENSP000003136614I2D: score=3 STRING: ENSP00000313661
    S1PR1P214533, ENSP000003054164I2D: score=3 STRING: ENSP00000305416
    S1PR3Q995003, ENSP000003508784I2D: score=3 STRING: ENSP00000350878
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response ISS--
    GO:0007186G-protein coupled receptor signaling pathway IMP--
    GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA8393041
    GO:0007210serotonin receptor signaling pathway ISS--
    GO:0008283cell proliferation IEA--

    Find genes that share ontologies with HTR1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HTR1A
      Browse compounds at ApexBio 

    Compounds for HTR1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WAY 100635 maleate Potent, 5-HT1A silent antagonist. Also D4 agonist [634908-75-1]
    Sumatriptan5-HT1A/1B/1D receptor agonist[103628-48-4]
    RU 24969 hemisuccinate5-HT1B/1A agonist[107008-28-6]
    NAD 299 hydrochloride Selective, high affinity 5-HT1A antagonist [169758-66-1]
    (S)-WAY 100135 dihydrochloride Potent, selective 5-HT1A antagonist [149007-54-5]

    6 HMDB Compounds for HTR1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    PropranololDociton (see all 8)525-66-6--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    Sertraline(+)-Sertraline (see all 3)79617-96-2--
    VenlafaxineEfectin (see all 6)93413-69-5--

    Selected DrugBank Compounds for HTR1A (see all 46)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BuspironeBuspirona [INN-Spanish] (see all 3)36505-84-7targetpartial agonist10221756 10064829 10027850 11752352 10428422 10215901 14769835
    Bopindolol-- 69010-88-4target--10088139 10490909 11752352 10435400 10432475 10331108
    Lisuride-- 18016-80-3targetagonist12373423 11224054 1678728 1783326 2887435 18691132
    PindololBetapindol (see all 2)13523-86-9targetantagonist10088139 10490909 11752352 10435400 10432475 10331108
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11910268 10516958 10924666 12923612 11132243
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist partial agonist14647959 15862515 15257633 12063084 14709325
    Clozapine-- 5786-21-0targetantagonist15213359 12589516 15261283 12923612 12564641
    MethysergideMethyllysergic acid butanolamide (see all 7)361-37-5targetagonist14501155 14517765 11049861 14581123 1838579
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7targetantagonist12445705 17848919 11132243 17563257 16918396
    AlprenololAlfeprol [Russian] (see all 3)13655-52-2targetantagonist1323650 9145928 8392199 9806333

    Selected IUPHAR Ligands for HTR1A (5-HT1A receptor) (see all 110)    About this table
    LigandTypeActionAffinityPubmed IDs
    S-14671
    AgonistFull agonist10.2 - 10.59760039 9550290
    5-CT
    AgonistFull agonist9.4 - 10.31386736 9550290 9760039 9205951
    LY293284
    AgonistFull agonist10.111101361
    roxindole
    AgonistPartial agonist9.4 - 9.910431754 12388666
    [3H]NAD 299
    AntagonistAntagonist9.89851589
    lisuride
    AgonistFull agonist9.7 - 9.89550290 9205951 12388666
    Rec 15/3079
    AntagonistAntagonist9.711714892
    U92016A
    AgonistFull agonist9.77965808
    S-14506
    AgonistFull agonist9.6 - 9.79760039 9550290
    5-HT
    AgonistFull agonist9.1 - 9.715628665 9760039 10431754 9205951 1386736 9550290

    Selected Novoseek inferred chemical compound relationships for HTR1A gene (see all 127)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    buspirone 91.8 139 9765347 (4), 11354671 (4), 11989622 (3), 1570392 (3) (see all 99)
    ipsapirone 91.1 65 9397426 (3), 10327431 (3), 1968842 (2), 9988364 (2) (see all 44)
    flesinoxan 89.1 49 9765347 (4), 9163561 (4), 10515319 (3), 15013031 (3) (see all 27)
    8-hydroxy-2-(di-n-propylamino)tetralin 88.1 49 1886079 (1), 1403790 (1), 7813581 (1), 7705452 (1) (see all 45)
    way 100635 86.6 31 8646424 (4), 19674881 (1), 9117564 (1), 9421295 (1) (see all 21)
    5-hydroxytryptamine 86 209 11356925 (5), 17540858 (3), 11198126 (3), 17663006 (3) (see all 96)
    pindolol 85.7 60 12166089 (4), 7566497 (3), 10435400 (3), 16452992 (3) (see all 37)
    s 15535 84.4 4 9550290 (1), 8381359 (1), 8831111 (1)
    gepirone 82.7 18 12484540 (2), 1762063 (2), 10780825 (2), 2157231 (1) (see all 14)
    tandospirone 82.1 16 11889759 (4), 11952922 (2), 11481861 (1), 8102330 (1) (see all 12)

    7 PharmGKB related drug/compound annotations for HTR1A gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    aripiprazole
    fluvoxamineCA  
    milnacipranCA  
    paroxetineCA  
    sertralineCA  



    Find genes that share compounds with HTR1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HTR1A gene: 
    NM_000524.3  

    Unigene Cluster for HTR1A:

    5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    Hs.247940  [show with all ESTs]
    Unigene Representative Sequence: NM_000524
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506598 ENST00000323865(uc011cqt.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HTR1A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HTR1A
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HTR1A
    Predesigned siRNA for gene silencing in human, mouse, rat HTR1A
    Clone
    Products:
         
    OriGene clones in human, mouse for HTR1A (see all 5)
    OriGene ORF clones in mouse, rat for HTR1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTR1A (NM_000524)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1A
    Addgene plasmids for HTR1A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HTR1A
    OriGene qSTAR qPCR primer pairs in human, mouse for HTR1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTR1A
      QuantiTect SYBR Green Assays in human, mouse, rat HTR1A
      QuantiFast Probe-based Assays in human, mouse, rat HTR1A

    Additional mRNA sequence: 

    AF498978.1 AK291429.1 AK311460.1 AK314187.1 BC069159.1 BC136263.1 S64045.1 

    1 DOTS entry:

    DT.102820664 

    7 AceView cDNA sequences:

    AF498978 BC069159 NM_000524 CD608772 CD608776 S64045 CD608773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HTR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR1A Expression
    About this image


    HTR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
    HTR1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTR1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247940

    UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
    Tissue specificity: Detected in lymph nodes, thymus and spleen. Detected in activated T cells, but not in resting
    T cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTR1A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HTR1A
    OriGene qSTAR qPCR primer pairs in human, mouse for HTR1A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTR1A
    QuantiTect SYBR Green Assays in human, mouse, rat HTR1A
    QuantiFast Probe-based Assays in human, mouse, rat HTR1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HTR1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1a1 , 5 5-hydroxytryptamine (serotonin) receptor 1A1, 5 85.59(n)1
    88.36(a)1
      13 (56.92 cM)5
    155501  NM_008308.41  NP_032334.21 
     1054436935 
    chicken
    (Gallus gallus)
    Aves HTR1A1 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 77.64(n)
    83.17(a)
      431581  NM_001170528.1  NP_001163999.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia htr1a-A2 5-hydroxytryptamine (serotonin) receptor 1A 75.6(n)    Y07901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr1aa1 5-hydroxytryptamine (serotonin) receptor 1A a 71.33(n)
    79.39(a)
      100001828  NM_001123321.1  NP_001116793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT1B3
    5-HT1A1
    serotonin receptor signaling pathway
    G-protein more3
    Serotonin receptor 1A1
    49(a)
    (best of 5)3
    58.61(n)1
    49.82(a)1
      56B13
    371961  NM_166322.21  NP_725849.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F14D12.63
    ser-41
    G-protein coupled receptor3
    ser-41
    30(a)3
    47.53(n)1
    42.86(a)1
      X(5644519-5646489)3
    1753221  NM_065051.51  NP_497452.11 


    ENSEMBL Gene Tree for HTR1A (if available)
    TreeFam Gene Tree for HTR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HTR1A gene
    ADRA1B2  HTR1F2  HTR72  ADRA2C2  ADRA2A2  HTR1D2  ADRA2B2  ADRA1A2  
    HTR1E2  HTR5A2  HTR1B2  ADRA1D2  
    Selected SIMAP similar genes for HTR1A using alignment to 2 protein entries:     5HT1A_HUMAN (see all proteins) (see all similar genes):
    5HT1A    5HT1a    HTR1D    HTR1B    HTR1F    HTR1E
    DRD3    DRD2    ADRA1D    ADRA2C    ADRA1B    ADRA1A
    CHRM1    HTR2C    HTR7    ADRA2B    CHRM2    DRD1

    Find genes that share paralogs with HTR1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HTR1A (see all 185)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403276231,2
    --63174978(+) GAATAC/TTTCAA 1 -- ds50010--------
    rs1455312841,2
    --63175073(+) GTGGGA/CGCGGC 1 -- ut310--------
    rs1846992611,2
    --63175158(+) TAGGAC/GATAGA 1 -- ut310--------
    rs8785671,2
    C,F,A,H--63175181(-) CCCAGC/TAATTG 1 -- ut3136Minor allele frequency- A:0.00EA NA NS WA CSA 3265
    rs1880193791,2
    --63175196(+) AAACTG/TATGAT 1 -- ut310--------
    rs64496931,2
    C,F,A,H--63175208(+) CAGGCA/GAAGTC 1 -- ut3128Minor allele frequency- G:0.31NS EA NA WA CSA 2781
    rs1381421501,2
    --63175266(+) AACGCC/TCCTCC 1 -- ut310--------
    rs1404711211,2
    --63175292(+) CACAAA/CGGGCC 1 -- ut310--------
    rs1930424841,2
    --63175303(+) CTGCCG/TTGGAG 1 -- ut310--------
    rs1852653681,2
    --63175331(+) ACCAGC/GTCTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HTR1A (63256183 - 63258334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4860CNV Insertion18451855

    Human Gene Mutation Database (HGMD): HTR1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for HTR1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 109760   
    OMIM disorders: 614674  
    UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
  • Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent
    fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual
    cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant
    change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in
    basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be
    triggered by the induction of several inflammatory cytokines. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • Selected diseases for HTR1A (see all 22):    
    About MalaCards
    agoraphobia    periodic fever, menstrual cycle dependent    anxiety disorder    postpartum depression
    drug psychosis    serotonin syndrome    memory impairment    premature ejaculation
    neuroleptic malignant syndrome    motion sickness    generalized anxiety disorder    social phobia
    chronic fatigue syndrome    machado-joseph disease    amnestic disorder    seasonal affective disorder
    panic disorder    migraine without aura    metachromatic leukodystrophy    temporal lobe epilepsy

    13 diseases from the University of Copenhagen DISEASES database for HTR1A:
    Generalized anxiety disorder     Schizophrenia     Panic disorder     Drug psychosis
    Migraine     Amnestic disorder     Pain agnosia     Bipolar disorder
    Sudden infant death syndrome     Premature ejaculation     Neuroleptic malignant syndrome     Motion sickness
    Parkinson's disease

    Find genes that share disorders with HTR1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HTR1A gene (see all 83)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    major depression 67.4 71 9736659 (3), 16139805 (3), 15534042 (2), 20026183 (2) (see all 43)
    mood disorders 64.5 19 16467535 (2), 16863269 (1), 16756688 (1), 15262317 (1) (see all 14)
    anxiety disorders 56.2 15 16979141 (3), 18047755 (2), 1763190 (2), 18163385 (2) (see all 7)
    schizophrenia 56.1 59 15023569 (5), 11277607 (4), 16831468 (3), 18849890 (3) (see all 31)
    catalepsy 55.5 21 12398907 (3), 9774248 (3), 10379620 (2), 15906386 (1) (see all 6)
    serotonin syndrome 48.9 8 1387164 (2), 9696181 (1), 10090793 (1), 15743927 (1)
    panic disorder 45.7 11 8888384 (2), 10870873 (1), 15534042 (1), 15683551 (1) (see all 9)
    generalized anxiety disorder 41.5 7 10356651 (1), 18344738 (1), 16856115 (1), 14985704 (1) (see all 7)
    unipolar depression 41.3 3 1977479 (2), 1971701 (1)
    obsessive-compulsive disorder 40.1 4 2188516 (1), 1763190 (1), 1686817 (1), 8056999 (1)

    Genetic Association Database (GAD): HTR1A
    Human Genome Epidemiology (HuGE) Navigator: HTR1A (131 documents)

    Export disorders for HTR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HTR1A gene, integrated from 10 sources (see all 1276):
    (articles sorted by number of sources associating them with HTR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. (PubMed id 9754630)1, 2, 4 Kawanishi Y.... Shiraishi H. (Am. J. Med. Genet. 1998)
    2. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. (PubMed id 15758168)1, 4, 9 David S.P....Grasby P.M. (J. Neurosci. 2005)
    3. Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders. (PubMed id 18163385)1, 4, 9 Hettema J.M....Chen X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. (PubMed id 19278673)1, 4, 9 Sullivan G.M....Parsey R.V. (Biol. Psychiatry 2009)
    5. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. (PubMed id 19829169)1, 4, 9 Villafuerte S.M....Burmeister M. (Psychiatr. Genet. 2009)
    6. The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. (PubMed id 15458611)1, 4, 9 Serretti A....Zanardi R. (Int. J. Neuropsychopharmacol. 2004)
    7. Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5- hydroxytryptamine. (PubMed id 8393041)1, 2, 9 Aune T.M.... Kelley K.A. (J. Immunol. 1993)
    8. Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs. (PubMed id 17417740)1, 4, 9 Marziniak M....Sommer C. (J Neural Transm 2007)
    9. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. (PubMed id 20043001)1, 4, 9 Juhasz G....Anderson I.M. (Neuropsychopharmacology 2010)
    10. Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C. (PubMed id 17408646)1, 4, 9 Kraus M.R....Scheurlen M. (Gastroenterology 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3350 HGNC: 5286 AceView: HTR1A Ensembl:ENSG00000178394 euGenes: HUgn3350
    ECgene: HTR1A Kegg: 3350 H-InvDB: HTR1A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HTR1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HTR1A gene:
    Search GeneIP for patents involving HTR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HTR1A
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for HTR1A (5-HT1A)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HTR1A   OriGene RNAi products in human, mouse, rat for HTR1A  
     OriGene qPCR primer pairs and template standards for HTR1A   OriGene Protein Over-expression Lysate for HTR1A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HTR1A  
     OriGene qSTAR qPCR primer pairs in human, mouse for HTR1A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HTR1A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HTR1A   OriGene Custom Protein Services for HTR1A  

     
     
     Block miRNA regulation of human, mouse, rat HTR1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HTR1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTR1A Predesigned siRNA for gene silencing in human, mouse, rat HTR1A
     QuantiFast Probe-based Assays in human, mouse, rat HTR1A QuantiTect SYBR Green Assays in human, mouse, rat HTR1A
     PCR Arrays including human, mouse, rat HTR1A Search Chromatin IP Primers for HTR1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTR1A  GeneGlobe Interaction Network for HTR1A
     Regulatory tfbs in HTR1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for HTR1A GenScript cDNA clones with any tag delivered in your preferred vector for HTR1A
     GenScript HTR1A-overexpressing Cell Line for Assay CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for HTR1A  (5-HT(1A))

     Tocris compounds for HTR1A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for HTR1A
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HTR1A antibodies
     HTR1A proteins
     HTR1A lysates
     Antibodies for HTR1A
     See all of Abcam's Antibodies, Kits and Proteins for HTR1A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HTR1A
     Antibodies for HTR1A
     ELISAs for HTR1A
     CLIAs for HTR1A



     Browse ESI BIO Cell Lines and PureStem Progenitors for HTR1A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HTR1A
     SwitchGear Promoter luciferase reporter plasmids for HTR1A
     ThermoFisher Antibodies for HTR1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1A
     Browse compounds at ApexBio
     Addgene plasmids for HTR1A
      Search eBioscience for proteins for HTR1A
      Search eBioscience for elisas for HTR1A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HTR1A
     antibodies-online antibodies for HTR1A (46 products)
     antibodies-online kits for HTR1A (7 products)
     antibodies-online peptides for HTR1A
     antibodies-online proteins for HTR1A (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HTR1A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4