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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HTR1A Gene

protein-coding GIFtS: 65
GCID: GC05M063292

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1A )
(Previous symbols: ADRB2RL1, ADRBRL1)

Explore 99 diseases affiliated with
HTR1A via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled¹ ²		5-HT1a Receptor²
ADRB2RL1¹ ² ³ ⁵		5-Hydroxytryptamine Receptor 1A²
5-HT1A¹ ² ³		5HT1a²
ADRBRL1¹ ² ³		PFMCD²
5-HT-1A² ³		Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor²
G-21² ³		Serotonin Receptor 1A³
5-Hydroxytryptamine (Serotonin) Receptor 1A¹

External Ids:	HGNC: 5286¹	Entrez Gene: 3350²	Ensembl: ENSG00000178394⁷	OMIM: 109760⁵	UniProtKB: P08908³

Export aliases for HTR1A gene to outside databases

Previous GC identifers: GC05M063417 GC05M064794 GC05M063226 GC05M063272 GC05M060210

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR1A:

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the

5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and

pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and

stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic

fevers. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

summary for HTR1A:

The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced and the human gene encoding

this receptor has been localized on chromosome 5 (5q11.2-q13). 5-HT1A receptor binding sites are located

primarily in limbic brain areas, notably the hypothalamus, lateral septum, cortical areas and the

mesencephalic raphe nuclei. 5-HT1A receptor ligands with agonist activity possess antianxiety,

antidepressant, antiaggressive, and perhaps anticraving, anticataleptic, antiemetic, and neuroprotective

properties.

Gene Wiki entry for HTR1A (5-HT1A receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HTR1A gene promoter:
CREB AP-1 deltaCREB ATF-2 c-Jun GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTR1A promoter sequence

Search SABiosciences Chromatin IP Primers for HTR1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13 Ensembl cytogenetic band: 5q12.3 HGNC cytogenetic band: 5q11.2-q13

HTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1A gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M063292: view genomic region (about GC identifiers)

Start:	63,256,183 bp from pter	End:	63,258,334 bp from pter
Size:	2,152 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908 (See protein sequence)

Recommended Name: 5-hydroxytryptamine receptor 1A

Size: 422 amino acids; 46107 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6LAE7

Explore the universe of human proteins at neXtProt for HTR1A: NX_P08908

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08908

HTR1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000515.2

ENSEMBL proteins:

ENSP00000423433 ENSP00000316244

Reactome Protein details: P08908
Human Recombinant Protein Products:

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	Uscn Proteins for HTR1A

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	3138543
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--
GO:0043025	neuronal cell body	--	--

HTR1A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HTR1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HTR1A for domains About GeneDecksing

4 InterPro domains/families:

IPR000610 5HT1A_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR002231 5HT_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P08908

ProtoNet protein and cluster: P08908

2 Blocks protein families:

IPB000610 5-hydroxytryptamine 1A receptor signature

IPB002231 5-hydroxytryptamine receptor signature

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Similarity: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A

sub-subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that

functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

that inhibit adenylate cyclase activity

Genatlas biochemistry entry for HTR1A:

5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate cyclase

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTR1A
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		Search LifeMap BioReagents cell lines for HTR1A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004993	serotonin receptor activity	IEA	--
GO:0008144	drug binding	--	--
GO:0051378	serotonin binding	--	--

HTR1A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HTR1A:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-outs for HTR1A: Htr1a^tm2Rhn Htr1a^tm1Toth Htr1a^tm1Rhn Htr1a^tm1Tct
5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Htr1a):

behavior/neurological

cardiovascular system

homeostasis/metabolism

mortality/aging

nervous system

HTR1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
G alpha (i) signalling events	0.44

Monoamine GPCRs

	Monoamine GPCRs	1.00			Serotonin receptors	0.36
	Amine ligand-binding receptors	0.79			Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics	0.20

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Neuroscience

Neuroscience

1.00

Ca, cAMP and Lipid Signaling

Ca, cAMP and Lipid Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1A

Intracellular Calcium Signaling

2 Cell Signaling Technology (CST) Pathways for HTR1A

	Ca, cAMP and Lipid Signaling
	Neuroscience

3 BioSystems Pathways for HTR1A

	SIDS Susceptibility Pathways
	GPCRs, Class A Rhodopsin-like
	Monoamine GPCRs

5/8 Reactome Pathways for HTR1A (see all 8)

	GPCR downstream signaling
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)
	Serotonin receptors

1 PharmGKB Pathway for HTR1A

Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for HTR1A):

Neuroactive ligand-receptor interaction

HTR1A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HTR1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/147 Interacting proteins for HTR1A (P08908³ ENSP00000316244⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 147)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAI3	P08754³, ENSP00000358867⁴	I2D: score=1 STRING: ENSP00000358867
HTR1B	P28222³, ENSP00000358963⁴	I2D: score=2 STRING: ENSP00000358963
HTR1D	P28221³, ENSP00000313661⁴	I2D: score=3 STRING: ENSP00000313661
S1PR1	P21453³, ENSP00000305416⁴	I2D: score=3 STRING: ENSP00000305416
S1PR3	Q99500³, ENSP00000350878⁴	I2D: score=3 STRING: ENSP00000350878

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	1330092
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	--	--
GO:0007210	serotonin receptor signaling pathway	TAS	9736659
GO:0007610	behavior	TAS	9736659
GO:0008284	positive regulation of cell proliferation	TAS	1330092

HTR1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HTR1A for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for HTR1A

Compounds for HTR1A available from Tocris Bioscience About this table

Compound	Action	CAS #
WAY 100635	Potent, selective 5-HT1A antagonist	[634908-75-1]
(R)-(+)-8-Hydroxy-DPAT hydrobromide	Selective 5-HT1A agonist. Enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)	[80300-09-0]
8-Hydroxy-DPAT hydrobromide	Selective 5-HT1A agonist. Also has moderate affinity for 5-HT7	[76135-31-4]
Tandospirone hydrochloride	Selective 5-HT1A partial agonist	[87760-53-0]
(S)-WAY 100135 dihydrochloride	Potent, selective 5-HT1A antagonist	[133025-23-7]

6 HMDB Compounds for HTR1A About this table

Compound	Synonyms	CAS #	PubMed Ids
Aripiprazole	Abilify (see all 3)	129722-12-9	--
Propranolol	Dociton (see all 8)	525-66-6	--
Quetiapine	Quetiapine fumarate (see all 2)	111974-69-7	--
Serotonin	3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)	50-67-9	--
Sertraline	(+)-Sertraline (see all 3)	79617-96-2	--
Venlafaxine	Efectin (see all 6)	93413-69-5	--

10/42 DrugBank Compounds for HTR1A (see all 42) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Buspirone	Buspirona [INN-Spanish] (see all 3)	36505-84-7	target	partial agonist	10221756 10064829 10027850 11752352 10428422 10215901 14769835
Bopindolol	--	69010-88-4	target	--	10088139 10490909 11752352 10435400 10432475 10331108
Lisuride	--	18016-80-3	target	agonist	12373423 11224054 1678728 1783326 2887435 18691132
Pindolol	Betapindol (see all 2)	13523-86-9	target	antagonist	10088139 10490909 11752352 10435400 10432475 10331108
Ziprasidone	Ziprasidone hydrochloride (see all 2)	146939-27-7	target	antagonist	14728084 11910268 10516958 10924666 12923612 11132243
Aripiprazole	OPC 31 (see all 2)	129722-12-9	target	antagonist partial agonist	14647959 15862515 15257633 12063084 14709325
Clozapine	--	5786-21-0	target	antagonist	15213359 12589516 15261283 12923612 12564641
Methysergide	Methyllysergic acid butanolamide (see all 7)	361-37-5	target	agonist	14501155 14517765 11049861 14581123 1838579
Quetiapine	Quetiapine fumarate (see all 2)	111974-69-7	target	antagonist	12445705 17848919 11132243 17563257 16918396
Alprenolol	Alfeprol [Russian] (see all 3)	13655-52-2	target	antagonist	1323650 9145928 8392199 9806333

10/127 Novoseek chemical compound relationships for HTR1A gene (see all 127) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
buspirone	91.8	139	9765347 (4), 11354671 (4), 11989622 (3), 1570392 (3) (see all 99)
ipsapirone	91.1	65	9397426 (3), 10327431 (3), 1968842 (2), 9988364 (2) (see all 44)
flesinoxan	89.1	49	9765347 (4), 9163561 (4), 10515319 (3), 15013031 (3) (see all 27)
8-hydroxy-2-(di-n-propylamino)tetralin	88.1	49	1886079 (1), 1403790 (1), 7813581 (1), 7705452 (1) (see all 45)
way 100635	86.6	31	8646424 (4), 19674881 (1), 9117564 (1), 9421295 (1) (see all 21)
5-hydroxytryptamine	86	209	11356925 (5), 17540858 (3), 11198126 (3), 17663006 (3) (see all 96)
pindolol	85.7	60	12166089 (4), 7566497 (3), 10435400 (3), 16452992 (3) (see all 37)
s 15535	84.4	4	9550290 (1), 8381359 (1), 8831111 (1)
gepirone	82.7	18	12484540 (2), 1762063 (2), 10780825 (2), 2157231 (1) (see all 14)
tandospirone	82.1	16	11889759 (4), 11952922 (2), 11481861 (1), 8102330 (1) (see all 12)

5 PharmGKB related drug/compound annotations for HTR1A gene

Drug/compound	PharmGKB Annotation
Selective serotonin reuptake inhibitors	CA
antidepressants	CA
fluvoxamine	CA
milnacipran	CA
paroxetine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about HTR1A / 5HT1A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HTR1A gene:

NM_000524.3

Unigene Cluster for HTR1A:

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Hs.247940 [show with all ESTs]

Unigene Representative Sequence: NM_000524

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506598 ENST00000323865(uc011cqt.2)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTR1A

Additional cDNA sequence:

AF498978.1 AK291429.1 AK311460.1 AK314187.1 BC069159.1 BC136263.1 S64045.1

1 DOTS entry:

DT.102820664

7 AceView cDNA sequences:

AF498978 BC069159 NM_000524 CD608776 CD608772 S64045 CD608773

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HTR1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See HTR1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTR1A

SOURCE GeneReport for Unigene cluster: Hs.247940

SABiosciences Expression via Pathway-Focused PCR Arrays including HTR1A:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Neurotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HTR1A gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	HTR1A¹	5-hydroxytryptamine (serotonin) receptor 1A	77.15(n) 82.8(a)	431581 NM_001170528.1 NP_001163999.1
African clawed frog (Xenopus laevis)	Amphibia	htr1a-A²	5-hydroxytryptamine (serotonin) receptor 1A	75.6(n)	Y07901.1
zebrafish (Danio rerio)	Actinopterygii	htr1aa¹	5-hydroxytryptamine (serotonin) receptor 1A a	71.33(n) 79.39(a)	100001828 NM_001123321.1 NP_001116793.1
fruit fly (Drosophila melanogaster)	Insecta	5-HT1B³ Oct-TyrR¹	serotonin receptor signaling pathway G-protein more³ Octopamine-Tyramine receptor¹	49(a) (best of 5)³ 55.27(n)¹ 43.87(a)¹	56B1³ 42452¹ NM_079695.3¹ NP_524419.2¹
worm (Caenorhabditis elegans)	Secernentea	F14D12.6³ ser-2¹	G-protein coupled receptor³ Protein SER-2¹	30(a)³ 49.08(n)¹ 37.85(a)¹	X(5644519-5646489)³ 182110¹ NM_001029168.1¹ NP_001024339.1¹

ENSEMBL Gene Tree for HTR1A (if available)
TreeFam Gene Tree for HTR1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HTR1A gene

DRD4² ADRA1B² DRD2² HTR1F² HTR7² ADRA2C² ADRA2A² HTR1D²

ADRA1A² ADRA2B² HTR1E² DRD3² HTR5A² HTR1B² ADRA1D²

18/22 SIMAP similar genes for HTR1A using alignment to 2 protein entries: 5HT1A_HUMAN (see all proteins) (see all similar genes):

5HT1A 5HT1a HTR1D HTR1B HTR1F HTR1E

DRD3 DRD2 ADRA1D ADRA2C ADRA1B ADRA1A

CHRM1 HTR2C HTR7 ADRA2B CHRM2 DRD1

HTR1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199708804^1,2	C	--	60211104(-)	`GAGCAC/GCTGCC`	2	T S	mis¹		0	--	--	--	--
rs139026797^1,2	C,F,	--	60211223(+)	`GCCATC/TTTGCG`	2	K	syn¹		1		NA	4540
rs181835946^1,2	C,	--	60211225(+)	`CATCTG/TGCGCT`	2	K Q	mis¹		0	--	--	--	--
rs150096239^1,2	C,F	--	60211326(+)	`TGGAGT/CTGCCC`	2	/N /S	mis¹		1		NA	4508
rs138438693^1,2	C	--	60211361(+)	`AGGGCG/CGCGCC`	2	/A	syn¹		1		NA	4510
rs199635945^1,2	C	--	60211367(+)	`GCGCCA/GTCGTC`	2	D	syn¹		1		EU	909
rs34158987^1,2	C	--	60211426(-)	`TGGGCG/ATGGAG`	2	/M /V	mis¹		1		--	384
rs202078108^1,2	C,	--	60211486(+)	`CGGGGC/TGGGAG`	2	T A	mis¹		0	--	--	--	--
rs142264665^1,2	C	--	60211495(+)	`AGATGC/TTCCAT`	2	T A	mis¹		1		NA	4402
rs75236124^1,2	C,	--	60211507(+)	`GCGGGT/GGTCCG`	2	/T /P	mis¹		1		EU	307

HapMap Linkage Disequilibrium report for HTR1A (63256183 - 63258334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HTR1A
1 CNV: 36425
Human Gene Mutation Database (HGMD): HTR1A

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTR1A

DNA2.0 Custom Variant and Variant Library Synthesis for HTR1A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HTR1A for disorders About GeneDecksing

OMIM gene information: 109760 OMIM disorders: --

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908

Defects in HTR1A are the cause of periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]. PFMC is a

condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual

cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation

triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree

Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is

believed to be triggered by the induction of several inflammatory cytokines

20/99 diseases for HTR1A (see all 99): About MalaCards

machado-joseph disease obsessive-compulsive disorder spinal cord injury seasonal affective disorder

generalized anxiety disorder sudden infant death syndrome periodic fever migraine without aura

attention deficit hyperactivity disorder neuroleptic malignant syndrome anxiety disorder age related macular degeneration

social phobia supranuclear palsy borderline personality disorder progressive supranuclear palsy

motion sickness metachromatic leukodystrophy developmental disabilities temporal lobe epilepsy

13 diseases from the University of Copenhagen DISEASES database for HTR1A:

Generalized anxiety disorder Schizophrenia Panic disorder Drug psychosis

Amnestic disorder Migraine Bipolar disorder Pain agnosia

Sudden infant death syndrome Neuroleptic malignant syndrome Premature ejaculation Parkinson's disease

Motion sickness

10/83 Novoseek disease relationships for HTR1A gene (see all 83) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
major depression	67.4	71	9736659 (3), 16139805 (3), 15534042 (2), 20026183 (2) (see all 43)
mood disorders	64.5	19	16467535 (2), 16863269 (1), 16756688 (1), 15262317 (1) (see all 14)
anxiety disorders	56.2	15	16979141 (3), 18047755 (2), 1763190 (2), 18163385 (2) (see all 7)
schizophrenia	56.1	59	15023569 (5), 11277607 (4), 16831468 (3), 18849890 (3) (see all 31)
catalepsy	55.5	21	12398907 (3), 9774248 (3), 10379620 (2), 15906386 (1) (see all 6)
serotonin syndrome	48.9	8	1387164 (2), 9696181 (1), 10090793 (1), 15743927 (1)
panic disorder	45.7	11	8888384 (2), 10870873 (1), 15534042 (1), 15683551 (1) (see all 9)
generalized anxiety disorder	41.5	7	10356651 (1), 18344738 (1), 16856115 (1), 14985704 (1) (see all 7)
unipolar depression	41.3	3	1977479 (2), 1971701 (1)
obsessive-compulsive disorder	40.1	4	2188516 (1), 1763190 (1), 1686817 (1), 8056999 (1)

Genetic Association Database (GAD): HTR1A
Human Genome Epidemiology (HuGE) Navigator: HTR1A (131 documents)

Export disorders for HTR1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HTR1A gene, integrated from 9 sources (see all 1239):
(articles sorted by number of sources associating them with HTR1A)

Utopia: connect your pdf to the dynamic
world of online information

Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. (PubMed id 9754630)^{1, 2, 4} Kawanishi Y.... Shiraishi H. (1998)
The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. (PubMed id 15458611)^{1, 4, 9} Serretti A....Zanardi R. (2004)
Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5- hydroxytryptamine. (PubMed id 8393041)^{1, 2, 9} Aune T.M.... Kelley K.A. (1993)
Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. (PubMed id 16302021)^{1, 4, 9} Hong C.J....Tsai S.J. (2006)
Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. (PubMed id 11163544)^{1, 4, 9} Masellis M....Kennedy J.L. (2001)
Evidence for a combined genetic effect of the 5-HT(1A) receptor and serotonin transporter genes in the clinical outcome of major depressive patients treated with citalopram. (PubMed id 15728438)^{1, 4, 9} Arias B....Fananas L. (2005)
Association analysis for the C-1019G promoter variant of the 5-HT1A receptor gene with auditory evoked potentials in major depression. (PubMed id 15539859)^{1, 4, 9} Chen T.J....Tsai S.J. (2004)
The effects of a 5-hydroxytryptamine 1A receptor gene polymorphism on the clinical response to fluvoxamine in depressed patients. (PubMed id 15148501)^{1, 4, 9} Suzuki Y....Someya T. (2004)
Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. (PubMed id 14984628)^{1, 4, 9} Rothe C....Lesch K.P. (2004)
Investigation of serotonin-related genes in antidepressant response. (PubMed id 15052272)^{1, 4, 9} Peters E.J....Hamilton S.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3350	HGNC: 5286	AceView: HTR1A	Ensembl:ENSG00000178394	euGenes: HUgn3350
ECgene: HTR1A	Kegg: 3350	H-InvDB: HTR1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HTR1A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HTR1A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HTR1A gene:
Search GeneIP for patents involving HTR1A

GeneCards and IP:
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HTR1A Gene

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

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HTR1A Gene

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

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