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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTR1A Gene

protein-coding   GIFtS: 67
GCID: GC05M063292

5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled

(Previous name: 5-hydroxytryptamine (serotonin) receptor 1A)
(Previous symbols: ADRB2RL1, ADRBRL1)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5-Hydroxytryptamine (Serotonin) Receptor 1A, G Protein-Coupled1 2     5-HT1a Receptor2
ADRB2RL11 2 3 5     5-Hydroxytryptamine Receptor 1A2
ADRBRL11 2 3     5HT1a2
5-HT-1A2 3     PFMCD2
5-HT1A2 3     Guanine Nucleotide-Binding Regulatory Protein-Coupled Receptor2
G-212 3     Serotonin Receptor 1A3
5-Hydroxytryptamine (Serotonin) Receptor 1A1     

External Ids:    HGNC: 52861   Entrez Gene: 33502   Ensembl: ENSG000001783947   OMIM: 1097605   UniProtKB: P089083   

Export aliases for HTR1A gene to outside databases

Previous GC identifers: GC05M063417 GC05M064794 GC05M063226 GC05M063272 GC05M060210


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTR1A Gene:
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the
5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and
pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety
and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent
periodic fevers. (provided by RefSeq, Jun 2012)

GeneCards Summary for HTR1A Gene: 
HTR1A (5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled) is a protein-coding gene. Diseases associated with HTR1A include anxiety disorder, and agoraphobia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Monoamine GPCRs. GO annotations related to this gene include serotonin receptor activity. An important paralog of this gene is HTR2A.

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
proteins that inhibit adenylate cyclase activity

summary for HTR1A Gene:
The serotonin 5-HT1A receptor was the first 5-HT receptor to be fully sequenced and the human gene encoding
this receptor has been localized on chromosome 5 (5q11.2-q13). 5-HT1A receptor binding sites are located
primarily in limbic brain areas, notably the hypothalamus, lateral septum, cortical areas and the
mesencephalic raphe nuclei. 5-HT1A receptor ligands with agonist activity possess antianxiety,
antidepressant, antiaggressive, and perhaps anticraving, anticataleptic, antiemetic, and neuroprotective
properties.

Gene Wiki entry for HTR1A (5-HT1A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTR1A gene promoter:
         CREB   AP-1   deltaCREB   ATF-2   c-Jun   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTR1A promoter sequence
   Search SABiosciences Chromatin IP Primers for HTR1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2-q13   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q11.2-q13

HTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTR1A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M063292:  view genomic region     (about GC identifiers)

Start:
63,256,183 bp from pter      End:
63,258,334 bp from pter
Size:
2,152 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908 (See protein sequence)
Recommended Name: 5-hydroxytryptamine receptor 1A  
Size: 422 amino acids; 46107 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6LAE7

Explore the universe of human proteins at neXtProt for HTR1A: NX_P08908

Explore proteomics data for HTR1A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08908

  • HTR1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTR1A Protein Expression
    REFSEQ proteins: NP_000515.2  
    ENSEMBL proteins: 
     ENSP00000423433   ENSP00000316244  
    Reactome Protein details: P08908
    Human Recombinant Protein Products for HTR1A: 
    EMD Millipore Purified and/or Recombinant HTR1A Protein
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    Novus Biologicals HTR1A Proteins
    Novus Biologicals HTR1A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTR1A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA--
    GO:0016021integral to membrane ----
    GO:0097458neuron part ----

    HTR1A for ontologies           About GeneDecksing



    HTR1A Antibody Products: 
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    Cloud-Clone Corp. ELISAs for HTR1A 
    Cloud-Clone Corp. CLIAs for HTR1A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HTR: 5-HT (serotonin) receptors
    HTRGP: GPCR / Class A : 5-HT (serotonin) receptors, GPCR only

    IUPHAR Guide to PHARMACOLOGY protein family classification: 5-HT1A receptor 
    5-Hydroxytryptamine receptors

    4 InterPro protein domains:
     IPR000610 5HT1A_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002231 5HT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P08908

    ProtoNet protein and cluster: P08908

    2 Blocks protein domains:
    IPB000610 5-hydroxytryptamine 1A receptor signature
    IPB002231 5-hydroxytryptamine receptor signature


    UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
    Similarity: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A
    sub-subfamily


    HTR1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5HT1A_HUMAN, P08908
    Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone
    that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G
    proteins that inhibit adenylate cyclase activity

         Genatlas biochemistry entry for HTR1A:
    5-hydroxytryptamine (serotonin) receptor,subtype IA,G protein coupled receptor superfamily,inhibiting adenylate
    cyclase

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004993serotonin receptor activity IMP--
    GO:0005515protein binding IPI--
         
    HTR1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTR1A:
     Increased HPV18 LCR reporter a 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Htr1a):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  mortality/aging  nervous system 

    HTR1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HTR1A: Htr1atm1Toth Htr1atm2Rhn Htr1atm1Rhn Htr1atm1Tct

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HTR1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTR1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTR1A 
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    miRNA
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of HTR1A 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTR1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HTR1A About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Monoamine GPCRs
    Monoamine GPCRs0.79
    Serotonin receptors0.36
    Amine ligand-binding receptors0.79
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics0.33
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4CREB Pathway
    Intracellular Calcium Signaling0.50
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HTR1A
        Intracellular Calcium Signaling

    2 Cell Signaling Technology (CST) Pathways for HTR1A
        Ca, cAMP and Lipid Signaling
    Neuroscience

    3 BioSystems Pathways for HTR1A
        SIDS Susceptibility Pathways
    GPCRs, Class A Rhodopsin-like
    Monoamine GPCRs

    5/8        Reactome Pathways for HTR1A (see all 8)
        GPCR downstream signaling
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)
    Serotonin receptors

    1 PharmGKB Pathway for HTR1A
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for HTR1A):
        Neuroactive ligand-receptor interaction
    Serotonergic synapse


    HTR1A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/148 Interacting proteins for HTR1A (P089081, 3 ENSP000003162444) via UniProtKB, MINT, STRING, and/or I2D (see all 148)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI3P087543, ENSP000003588674I2D: score=1 STRING: ENSP00000358867
    HTR1BP282223, ENSP000003589634I2D: score=2 STRING: ENSP00000358963
    HTR1DP282213, ENSP000003136614I2D: score=3 STRING: ENSP00000313661
    S1PR1P214533, ENSP000003054164I2D: score=3 STRING: ENSP00000305416
    S1PR3Q995003, ENSP000003508784I2D: score=3 STRING: ENSP00000350878
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response ISS--
    GO:0007186G-protein coupled receptor signaling pathway IMP--
    GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA8393041
    GO:0007210serotonin receptor signaling pathway ISS--
    GO:0007610behavior ----

    HTR1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTR1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for HTR1A

    Compounds for HTR1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WAY 100635 maleate Potent, 5-HT1A silent antagonist. Also D4 agonist [634908-75-1]
    Sumatriptan5-HT1A/1B/1D receptor agonist[103628-48-4]
    RU 24969 hemisuccinate5-HT1B/1A agonist[107008-28-6]
    NAD 299 hydrochloride Selective, high affinity 5-HT1A antagonist [169758-66-1]
    (S)-WAY 100135 dihydrochloride Potent, selective 5-HT1A antagonist [149007-54-5]

    6 HMDB Compounds for HTR1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    AripiprazoleAbilify (see all 3)129722-12-9--
    PropranololDociton (see all 8)525-66-6--
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7--
    Serotonin3-(2-Aminoethyl)-1H-indol-5-ol (see all 14)50-67-9--
    Sertraline(+)-Sertraline (see all 3)79617-96-2--
    VenlafaxineEfectin (see all 6)93413-69-5--

    10/46 DrugBank Compounds for HTR1A (see all 46)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BuspironeBuspirona [INN-Spanish] (see all 3)36505-84-7targetpartial agonist10221756 10064829 10027850 11752352 10428422 10215901 14769835
    Bopindolol-- 69010-88-4target--10088139 10490909 11752352 10435400 10432475 10331108
    Lisuride-- 18016-80-3targetagonist12373423 11224054 1678728 1783326 2887435 18691132
    PindololBetapindol (see all 2)13523-86-9targetantagonist10088139 10490909 11752352 10435400 10432475 10331108
    ZiprasidoneZiprasidone hydrochloride (see all 2)146939-27-7targetantagonist14728084 11910268 10516958 10924666 12923612 11132243
    AripiprazoleOPC 31 (see all 2)129722-12-9targetantagonist partial agonist14647959 15862515 15257633 12063084 14709325
    Clozapine-- 5786-21-0targetantagonist15213359 12589516 15261283 12923612 12564641
    MethysergideMethyllysergic acid butanolamide (see all 7)361-37-5targetagonist14501155 14517765 11049861 14581123 1838579
    QuetiapineQuetiapine fumarate (see all 2)111974-69-7targetantagonist12445705 17848919 11132243 17563257 16918396
    AlprenololAlfeprol [Russian] (see all 3)13655-52-2targetantagonist1323650 9145928 8392199 9806333

    10/110 IUPHAR Ligands for HTR1A (5-HT1A receptor) (see all 110)    About this table 
    LigandTypeActionAffinityPubmed IDs
    S-14671
    AgonistFull agonist10.2 - 10.59760039 9550290
    5-CT
    AgonistFull agonist9.4 - 10.31386736 9550290 9760039 9205951
    LY293284
    AgonistFull agonist10.111101361
    roxindole
    AgonistPartial agonist9.4 - 9.910431754 12388666
    [3H]NAD 299
    AntagonistAntagonist9.89851589
    lisuride
    AgonistFull agonist9.7 - 9.89550290 9205951 12388666
    Rec 15/3079
    AntagonistAntagonist9.711714892
    U92016A
    AgonistFull agonist9.77965808
    S-14506
    AgonistFull agonist9.6 - 9.79760039 9550290
    5-HT
    AgonistFull agonist9.1 - 9.715628665 9760039 10431754 9205951 1386736 9550290

    10/127 Novoseek inferred chemical compound relationships for HTR1A gene (see all 127)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    buspirone 91.8 139 9765347 (4), 11354671 (4), 11989622 (3), 1570392 (3) (see all 99)
    ipsapirone 91.1 65 9397426 (3), 10327431 (3), 1968842 (2), 9988364 (2) (see all 44)
    flesinoxan 89.1 49 9765347 (4), 9163561 (4), 10515319 (3), 15013031 (3) (see all 27)
    8-hydroxy-2-(di-n-propylamino)tetralin 88.1 49 1886079 (1), 1403790 (1), 7813581 (1), 7705452 (1) (see all 45)
    way 100635 86.6 31 8646424 (4), 19674881 (1), 9117564 (1), 9421295 (1) (see all 21)
    5-hydroxytryptamine 86 209 11356925 (5), 17540858 (3), 11198126 (3), 17663006 (3) (see all 96)
    pindolol 85.7 60 12166089 (4), 7566497 (3), 10435400 (3), 16452992 (3) (see all 37)
    s 15535 84.4 4 9550290 (1), 8381359 (1), 8831111 (1)
    gepirone 82.7 18 12484540 (2), 1762063 (2), 10780825 (2), 2157231 (1) (see all 14)
    tandospirone 82.1 16 11889759 (4), 11952922 (2), 11481861 (1), 8102330 (1) (see all 12)

    5 PharmGKB related drug/compound annotations for HTR1A gene    About this table
    Drug/compound PharmGKB Annotation
    Selective serotonin reuptake inhibitorsCA  
    antidepressantsCA  
    fluvoxamineCA  
    milnacipranCA  
    paroxetineCA  

    Search CenterWatch for drugs/clinical trials and news about HTR1A / 5HT1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTR1A gene: 
    NM_000524.3  

    Unigene Cluster for HTR1A:

    5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
    Hs.247940  [show with all ESTs]
    Unigene Representative Sequence: NM_000524
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506598 ENST00000323865(uc011cqt.2)

    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTR1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTR1A
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    Additional mRNA sequence: 

    AF498978.1 AK291429.1 AK311460.1 AK314187.1 BC069159.1 BC136263.1 S64045.1 

    1 DOTS entry:

    DT.102820664 

    7 AceView cDNA sequences:

    AF498978 BC069159 CD608776 CD608772 NM_000524 S64045 CD608773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTR1A expression in normal human tissues (normalized intensities)      HTR1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HTR1A Expression
    About this image


    HTR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See HTR1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTR1A

    SOURCE GeneReport for Unigene cluster: Hs.247940
        SABiosciences Expression via Pathway-Focused PCR Arrays including HTR1A: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HTR1A gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htr1a1 , 5 5-hydroxytryptamine (serotonin) receptor 1A1, 5 85.59(n)1
    88.36(a)1
      13 (56.92 cM)5
    155501  NM_008308.41  NP_032334.21 
     1054436935 
    chicken
    (Gallus gallus)
    Aves HTR1A1 5-hydroxytryptamine (serotonin) receptor 1A 77.15(n)
    82.8(a)
      431581  NM_001170528.1  NP_001163999.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia htr1a-A2 5-hydroxytryptamine (serotonin) receptor 1A 75.6(n)    Y07901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii htr1aa1 5-hydroxytryptamine (serotonin) receptor 1A a 71.33(n)
    79.39(a)
      100001828  NM_001123321.1  NP_001116793.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta 5-HT1B3
    Oct-TyrR1
    serotonin receptor signaling pathway
    G-protein more3
    Octopamine-Tyramine receptor1
    49(a)
    (best of 5)3
    55.27(n)1
    43.87(a)1
      56B13
    424521  NM_079695.31  NP_524419.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F14D12.63
    ser-21
    G-protein coupled receptor3
    Protein SER-21
    30(a)3
    49.08(n)1
    37.85(a)1
      X(5644519-5646489)3
    1821101  NM_001029168.11  NP_001024339.11 


    ENSEMBL Gene Tree for HTR1A (if available)
    TreeFam Gene Tree for HTR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTR1A gene
    HTR2A2  DRD42  DRD22  HTR1F2  HTR72  HTR2B2  ADRA2C2  HTR2C2  
    ADRA2A2  HTR1D2  ADRA2B2  DRD32  HTR1E2  HTR5A2  HTR1B2  
    18/19 SIMAP similar genes for HTR1A using alignment to 2 protein entries:     5HT1A_HUMAN (see all proteins) (see all similar genes):
    5HT1A    5HT1a    HTR1D    HTR1B    HTR1F    HTR1E
    DRD3    DRD2    ADRA1D    ADRA2C    ADRA1B    ADRA1A
    CHRM1    HTR2C    HTR7    ADRA2B    CHRM2    DRD1

    HTR1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 SNPs in HTR1A are shown (see all 185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403276231,2
    --63174978(+) GAATAC/TTTCAA 1 -- ds50010--------
    rs1455312841,2
    --63175073(+) GTGGGA/CGCGGC 1 -- ut310--------
    rs1846992611,2
    --63175158(+) TAGGAC/GATAGA 1 -- ut310--------
    rs8785671,2
    C,F,A,H--63175181(-) CCCAGC/TAATTG 1 -- ut3136Minor allele frequency- A:0.00EA NA NS WA CSA 3265
    rs1880193791,2
    --63175196(+) AAACTG/TATGAT 1 -- ut310--------
    rs64496931,2
    C,F,A,H--63175208(+) CAGGCA/GAAGTC 1 -- ut3128Minor allele frequency- G:0.31NS EA NA WA CSA 2781
    rs1381421501,2
    --63175266(+) AACGCC/TCCTCC 1 -- ut310--------
    rs1404711211,2
    --63175292(+) CACAAA/CGGGCC 1 -- ut310--------
    rs1930424841,2
    --63175303(+) CTGCCG/TTGGAG 1 -- ut310--------
    rs1852653681,2
    --63175331(+) ACCAGC/GTCTGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HTR1A (63256183 - 63258334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HTR1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4860CNV Insertion18451855


    Human Gene Mutation Database (HGMD): HTR1A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109760    OMIM disorders: --

    UniProtKB/Swiss-Prot: 5HT1A_HUMAN, P08908
  • Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent
    fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual
    cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant
    change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in
    basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be
    triggered by the induction of several inflammatory cytokines. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 20/92 diseases for HTR1A (see all 92):    About MalaCards
    anxiety disorder    agoraphobia    parametritis    postpartum depression
    endogenous depression    generalized anxiety disorder    serotonin syndrome    tourette disorder
    premature ejaculation    machado-joseph disease    neuroleptic malignant syndrome    drug psychosis
    chronic fatigue syndrome    seasonal affective disorder    major depressive disorder    panic disorder
    borderline personality disorder    social phobia    motion sickness    temporal lobe epilepsy

    13 diseases from the University of Copenhagen DISEASES database for HTR1A:
    Generalized anxiety disorder     Schizophrenia     Panic disorder     Drug psychosis
    Migraine     Amnestic disorder     Pain agnosia     Bipolar disorder
    Sudden infant death syndrome     Premature ejaculation     Neuroleptic malignant syndrome     Motion sickness
    Parkinson's disease

    HTR1A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/83 Novoseek inferred disease relationships for HTR1A gene (see all 83)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    major depression 67.4 71 9736659 (3), 16139805 (3), 15534042 (2), 20026183 (2) (see all 43)
    mood disorders 64.5 19 16467535 (2), 16863269 (1), 16756688 (1), 15262317 (1) (see all 14)
    anxiety disorders 56.2 15 16979141 (3), 18047755 (2), 1763190 (2), 18163385 (2) (see all 7)
    schizophrenia 56.1 59 15023569 (5), 11277607 (4), 16831468 (3), 18849890 (3) (see all 31)
    catalepsy 55.5 21 12398907 (3), 9774248 (3), 10379620 (2), 15906386 (1) (see all 6)
    serotonin syndrome 48.9 8 1387164 (2), 9696181 (1), 10090793 (1), 15743927 (1)
    panic disorder 45.7 11 8888384 (2), 10870873 (1), 15534042 (1), 15683551 (1) (see all 9)
    generalized anxiety disorder 41.5 7 10356651 (1), 18344738 (1), 16856115 (1), 14985704 (1) (see all 7)
    unipolar depression 41.3 3 1977479 (2), 1971701 (1)
    obsessive-compulsive disorder 40.1 4 2188516 (1), 1763190 (1), 1686817 (1), 8056999 (1)

    Genetic Association Database (GAD): HTR1A
    Human Genome Epidemiology (HuGE) Navigator: HTR1A (131 documents)

    Export disorders for HTR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTR1A gene, integrated from 9 sources (see all 1263):
    (articles sorted by number of sources associating them with HTR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. (PubMed id 9754630)1, 2, 4 Kawanishi Y.... Shiraishi H. (1998)
    2. A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. (PubMed id 15758168)1, 4, 9 David S.P....Grasby P.M. (2005)
    3. Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders. (PubMed id 18163385)1, 4, 9 Hettema J.M....Chen X. (2008)
    4. Positron Emission Tomography Quantification of Serotonin-1A Receptor Binding in Medication-Free Bipolar Depression. (PubMed id 19278673)1, 4, 9 Sullivan G.M....Parsey R.V. (2009)
    5. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. (PubMed id 19829169)1, 4, 9 Villafuerte S.M....Burmeister M. (2009)
    6. The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. (PubMed id 15458611)1, 4, 9 Serretti A....Zanardi R. (2004)
    7. Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5- hydroxytryptamine. (PubMed id 8393041)1, 2, 9 Aune T.M.... Kelley K.A. (1993)
    8. Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs. (PubMed id 17417740)1, 4, 9 Marziniak M....Sommer C. (2007)
    9. Risk-taking behavior in a gambling task associated wi th variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric di sorders. (PubMed id 20043001)1, 4, 9 Juhasz G....Anderson I.M. (2010)
    10. Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C. (PubMed id 17408646)1, 4, 9 Kraus M.R....Scheurlen M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3350 HGNC: 5286 AceView: HTR1A Ensembl:ENSG00000178394 euGenes: HUgn3350
    ECgene: HTR1A Kegg: 3350 H-InvDB: HTR1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTR1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTR1A gene:
    Search GeneIP for patents involving HTR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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