HTN3 Gene
protein-coding GIFtS: 46
GCID: GC04P070894
|
|
histatin 3
| |
Aliases for HTN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Histatin 31 2 | | HTN52 | | HIS21 2 3 5 | | Histatin 52 | | Basic Histidine-Rich Protein2 3 | | Histatin-31 | | Histidine-Rich Protein 32 3 | | Hst3 | | PB2 3 | | Hst3 | | HTN22 5 | | |
Export aliases for HTN3 gene to outside databasesPrevious GC identifers: GC04P070804 GC04P070942 GC04P071144 GC04P071209 GC04P071074 GC04P066691 |
Summaries for HTN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for HTN3: This gene encodes a member of the histatin family of small, histidine-rich salivary proteins. Histatins exhibitnon-immunological, anti-microbial activity in the oral cavity. (provided by RefSeq, May 2009) UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516Function: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceousstructure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibitsLys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor ofmetalloproteinases MMP2 and MMP9 Gene Wiki entry for HTN3
|
Genomic Views for HTN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_022778.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HTN3 gene promoter: Nkx3-1 v2 Nkx3-1 Nkx3-1 v4 Nkx3-1 v3 Nkx3-1 v1 Other transcription factors
Search SABiosciences Chromatin IP Primers for HTN3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTN3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q13 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13HTN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P070894: view genomic region
(about GC identifiers)
Start:
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70,894,130 bp from pter |
End:
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70,902,255 bp from pter |
Size:
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8,126 bases |
Orientation:
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plus strand |
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Proteins for HTN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516 (See
protein sequence)Recommended Name: Histatin-3 precursor Size: 51 amino acids; 6149 Da
Subunit: His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2proteins
Subcellular location: Secreted. Note=Secreted by serous acinar and demilune cells
Miscellaneous: The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). Inagreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positionswithin the precursor, and not in the mature protein, as has formerly been proposed
Secondary accessions: Q16243 Q502Z1Explore the universe of human proteins at neXtProt for HTN3: NX_P15516
Post-translational modifications:
24 proteolytic products are found in saliva1
View neXtProt modification sites for NX_P15516 HTN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000191.1 ENSEMBL proteins: ENSP00000437158 ENSP00000432561 ENSP00000370445 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
HTN3 for ontologies About GeneDecksing
HTN3 Antibody Products: Assay Products for HTN3: |
Protein
Domains / Families for HTN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P15516 UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516Similarity: Belongs to the histatin/statherin family |
Function for HTN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516Function: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceousstructure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibitsLys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor ofmetalloproteinases MMP2 and MMP9 Genatlas biochemistry entry for HTN3:histatin 3
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTN3 (NM_000200) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046872 | metal ion binding |
IEA | -- |
HTN3 for ontologies About GeneDecksing
|
Pathways & Interactions for HTN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTN3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for HTN3 (P155162, 3 ENSP000003704454) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
HTN3 for ontologies About GeneDecksing
|
Drugs & Compounds for HTN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HTN3 for compounds About GeneDecksing
Browse Tocris compounds for HTN3 10/23 Novoseek chemical compound relationships for HTN3 gene (see all 23) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pgla |
75.6 |
2 |
11099499 (1), 11204768 (1) |
| anti-fungal |
71.9 |
21 |
16901460 (3), 11099499 (2), 16919097 (1), 9333052 (1) (see all 16) |
| trifluoroethanol |
68.1 |
5 |
10423240 (2), 9923693 (1), 11454169 (1), 2406266 (1) |
| sodium azide |
57 |
3 |
11816973 (1), 11717389 (1), 10639361 (1) |
| miconazole |
39.2 |
2 |
9333052 (1), 15073161 (1) |
| tannins |
37.7 |
15 |
7575474 (4), 10794615 (2) |
| amphotericin b |
35.6 |
6 |
11204768 (3), 18566844 (1), 15073161 (1) |
| hydroxyapatite |
28.5 |
17 |
16055080 (3), 12711380 (3), 8297263 (2) |
| fluconazole |
26.4 |
1 |
12499171 (1) |
| copper |
23.8 |
6 |
11226423 (3), 17482573 (1), 19846304 (1) |
Search CenterWatch for drugs/clinical trials and news about HTN3 / HIS3 
|
Transcripts for HTN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HTN3 gene: NM_000200.2 Unigene Cluster for HTN3: Histatin 3 Hs.654442 [show with all ESTs]Unigene Representative Sequence: CR7494106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526767(uc003hew.2) ENST00000530128 ENST00000528003 ENST00000529625 ENST00000533547 ENST00000381057
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HTN3 (NM_000200) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HTN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3  |
Additional cDNA sequence: BC009791.1 BC095438.1 CR749410.1 M18372.1 M26665.1 24/35 DOTS entries (see all 35): DT.100829014 DT.121249549 DT.444397 DT.100829038 DT.121249385 DT.92420462 DT.121249603 DT.100829029 DT.121249367 DT.100680399 DT.100744211 DT.100755270 DT.100829023 DT.100829033 DT.100829044 DT.100829048 DT.121249380 DT.100755269 DT.100829035 DT.100829045 DT.100741061 DT.100829022 DT.100829028 DT.100829030 24/1728 AceView cDNA sequences (see all 1728): AA382524 BP334251 BP334022 BP333885 AA376496 AA376688 AA376493 BP334413 AA376717 AA376710 BP334484 BP334762 BP334178 AA376712 BP334623 BX486743 BP335111 AA376645 BP333958 AA367534 BP334472 BX485098 AA376638 CB986649 GeneLoc Exon Structure
|
Expression for HTN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HTN3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATTATGGAGG
About this image See HTN3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HTN3
SOURCE GeneReport for Unigene cluster: Hs.654442 SABiosciences Custom PCR Arrays for HTN3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTN3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTN3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTN3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTN3 |
Orthologs for HTN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for HTN3 (if available) TreeFam Gene Tree for HTN3 (if available)  |
Paralogs for HTN3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for HTN3 gene
- HTN12
1 SIMAP similar gene for HTN3 using alignment to 1 protein entry: HIS3_HUMAN:HTN1
HTN3 for paralogs About GeneDecksing
|
Genomic Variants for HTN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516Polymorphism: There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2found primarily and in high frequencies in black populations
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 4 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for HTN3 (70894130 - 70902255 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HTN3: -- Human Gene Mutation Database (HGMD): HTN3
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTN3 |
|
Disorders
/ Diseases for HTN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HTN3 for disorders About GeneDecksing
OMIM gene information: 142702
OMIM disorders: --
14 diseases for HTN3: About MalaCardscandida glabrata sporotrichosis oral candidiasis candidiasis acrodysostosis periodontal disease periodontitis cystic fibrosis hepatitis b fibrosis gingivitis immunodeficiency peritonitis hepatitis
5 Novoseek disease relationships for HTN3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: HTN3 (2 documents) Export disorders for HTN3 gene to outside databases
|
Publications for HTN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HTN3 gene, integrated from 9 sources (see all 124): (articles sorted by number of sources associating them with HTN3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PubMed id 15272024)1, 2, 9 Castagnola M....Messana I. (2004)
- Zinc and copper bind to unique sites of histatin 5. (PubMed id 11226423)1, 2, 9 Grogan J.... Oppenheim F.G. (2001)
- Candidacidal activity of recombinant human salivary histatin-5 and variants. (PubMed id 8945538)1, 2, 9 Tsai H.... Bobek L.A. (1996)
- Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PubMed id 8336540)1, 2, 9 Chen Z.W. (1993)
- Molecular cloning of human submandibular histatins. (PubMed id 2344289)1, 2, 9 Vanderspek J.C.... Oppenheim F.G. (1990)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Immunocytochemical localization of histatins in human salivary glands. (PubMed id 14966203)1, 2 Ahmad M.... Hand A.R. (2004)
- Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. (PubMed id 12761219)1, 2 Li X.S.... Edgerton M. (2003)
- Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. (PubMed id 11179305)1, 2 Gusman H....Oppenheim F.G. (2001)
- Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant. (PubMed id 7951254)1, 2 Sabatini L.M. and Azen E.A. (1994)
|
External Searches for HTN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HTN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HTN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HTN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HTN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HTN3 gene: Search GeneIP for patents involving HTN3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HTN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HTN3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTN3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTN3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTN3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTN3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTN3 |
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| | | Search Tocris compounds for HTN3 |
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 | | HTN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | Search ThermoFisher Antibodies for HTN3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3 |
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