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Aliases for HTN3 Gene

Aliases for HTN3 Gene

  • Histatin 3 2 3 5
  • Basic Histidine-Rich Protein 3 4
  • Histidine-Rich Protein 3 3 4
  • HIS2 3 4
  • HST 3 4
  • PB 3 4
  • Histatin 5 3
  • Histatin-4 3
  • Histatin-5 3
  • Histatin-6 3
  • Histatin-7 3
  • Histatin-8 3
  • Histatin-9 3
  • HTN2 3
  • HTN5 3

External Ids for HTN3 Gene

Previous GeneCards Identifiers for HTN3 Gene

  • GC04P070804
  • GC04P070942
  • GC04P071144
  • GC04P071209
  • GC04P071074
  • GC04P066691
  • GC04P070894

Summaries for HTN3 Gene

Entrez Gene Summary for HTN3 Gene

  • This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

GeneCards Summary for HTN3 Gene

HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include candida glabrata and oral candidiasis. Among its related pathways are Salivary secretion. An important paralog of this gene is HTN1.

UniProtKB/Swiss-Prot for HTN3 Gene

  • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Gene Wiki entry for HTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene

Genomics for HTN3 Gene

Regulatory Elements for HTN3 Gene

Genomic Location for HTN3 Gene

Chromosome:
4
Start:
70,028,413 bp from pter
End:
70,036,538 bp from pter
Size:
8,126 bases
Orientation:
Plus strand

Genomic View for HTN3 Gene

Genes around HTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTN3 Gene

Proteins for HTN3 Gene

  • Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15516-HIS3_HUMAN
    Recommended name:
    Histatin-3
    Protein Accession:
    P15516
    Secondary Accessions:
    • Q16243
    • Q502Z1

    Protein attributes for HTN3 Gene

    Size:
    51 amino acids
    Molecular mass:
    6149 Da
    Quaternary structure:
    • His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins.
    Miscellaneous:
    • The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

neXtProt entry for HTN3 Gene

Proteomics data for HTN3 Gene at MOPED

Post-translational modifications for HTN3 Gene

Other Protein References for HTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTN3 Gene

Domains & Families for HTN3 Gene

Gene Families for HTN3 Gene

Protein Domains for HTN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HTN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15516

UniProtKB/Swiss-Prot:

HIS3_HUMAN :
  • Belongs to the histatin/statherin family.
Family:
  • Belongs to the histatin/statherin family.
genes like me logo Genes that share domains with HTN3: view

Function for HTN3 Gene

Molecular function for HTN3 Gene

GENATLAS Biochemistry:
histatin 3
UniProtKB/Swiss-Prot Function:
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Phenotypes for HTN3 Gene

genes like me logo Genes that share phenotypes with HTN3: view

Animal Model Products

miRNA for HTN3 Gene

miRTarBase miRNAs that target HTN3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTN3 Gene

Localization for HTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene

Secreted. Note=Secreted by serous acinar and demilune cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTN3 Gene COMPARTMENTS Subcellular localization image for HTN3 gene
Compartment Confidence
extracellular 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for HTN3 Gene

Pathways & Interactions for HTN3 Gene

SuperPathways for HTN3 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with HTN3: view

Pathways by source for HTN3 Gene

1 KEGG pathway for HTN3 Gene

Interacting Proteins for HTN3 Gene

Gene Ontology (GO) - Biological Process for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium IEA,NAS 3286634
genes like me logo Genes that share ontologies with HTN3: view

No data available for SIGNOR curated interactions for HTN3 Gene

Drugs & Compounds for HTN3 Gene

(12) Drugs for HTN3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for HTN3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HTN3: view

Transcripts for HTN3 Gene

Unigene Clusters for HTN3 Gene

Histatin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTN3 Gene

No ASD Table

Relevant External Links for HTN3 Gene

GeneLoc Exon Structure for
HTN3
ECgene alternative splicing isoforms for
HTN3

Expression for HTN3 Gene

mRNA expression in normal human tissues for HTN3 Gene

mRNA differential expression in normal tissues according to GTEx for HTN3 Gene

This gene is overexpressed in Pituitary (x40.1), Minor Salivary Gland (x4.4), and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for HTN3 Gene

This gene is overexpressed in Saliva (56.2) and Salivary gland (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HTN3 Gene



SOURCE GeneReport for Unigene cluster for HTN3 Gene Hs.654442

genes like me logo Genes that share expression patterns with HTN3: view

Protein tissue co-expression partners for HTN3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HTN3 Gene

Orthologs for HTN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HTN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTN3 35
  • 99.35 (n)
  • 98.04 (a)
HTN3 36
  • 98 (a)
OneToOne
Species with no ortholog for HTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTN3 Gene

ENSEMBL:
Gene Tree for HTN3 (if available)
TreeFam:
Gene Tree for HTN3 (if available)

Paralogs for HTN3 Gene

Paralogs for HTN3 Gene

(1) SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTN3: view

Variants for HTN3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene

P15516-HIS3_HUMAN
There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations.

Sequence variations from dbSNP and Humsavar for HTN3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1136511 - 70,033,186(+) ACATC(A/G)AGGCT reference, missense
rs776845 -- 70,026,469(+) TCAGT(A/T)AGCTA upstream-variant-2KB
rs776846 -- 70,026,783(+) AACAG(G/T)TATCT upstream-variant-2KB
rs776847 -- 70,026,952(+) AATAA(C/T)ATATA upstream-variant-2KB
rs776848 -- 70,029,449(+) AGATG(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTN3 Gene

Variant ID Type Subtype PubMed ID
dgv5628n71 CNV Loss 21882294
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294
dgv5630n71 CNV Loss 21882294
nsv879463 CNV Loss 21882294

Variation tolerance for HTN3 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTN3 Gene

HapMap Linkage Disequilibrium report
HTN3
Human Gene Mutation Database (HGMD)
HTN3

Disorders for HTN3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HTN3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
candida glabrata
  • torulopsis glabrata
oral candidiasis
  • candidiasis of mouth
candidiasis
  • disseminated candidiasis
hypertropia
cerebral creatine deficiency syndrome 3
  • agat deficiency
- elite association - COSMIC cancer census association via MalaCards
Search HTN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTN3

Genetic Association Database (GAD)
HTN3
Human Genome Epidemiology (HuGE) Navigator
HTN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTN3
genes like me logo Genes that share disorders with HTN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTN3 Gene

Publications for HTN3 Gene

  1. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M. … Messana I. (J. Biol. Chem. 2004) 3 4 23 67
  2. Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts. (PMID: 19321452) Imamura Y. … Wang P.L. (J. Biol. Chem. 2009) 3 23
  3. Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PMID: 19753800) Fujigaki Y. … Wang P.L. (J Int Acad Periodontol 2009) 3 23
  4. Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. (PMID: 18230684) Luque-Ortega J.R. … Rivas L. (FASEB J. 2008) 3 23
  5. Metal-binding and nuclease activity of an antimicrobial peptide analogue of the salivary histatin 5. (PMID: 17176059) Melino S. … Petruzzelli R. (Biochemistry 2006) 3 23

Products for HTN3 Gene

Sources for HTN3 Gene

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