Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTN3 Gene

protein-coding   GIFtS: 46
GCID: GC04P070894

histatin 3

 Explore 14 diseases affiliated with
HTN3 via our new
 Human Malady Compendium 
Biological research products
for HTN3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histatin 31 2     HTN52
HIS21 2 3 5     Histatin 52
Basic Histidine-Rich Protein2 3     Histatin-31
Histidine-Rich Protein 32 3     Hst3
PB2 3     Hst3
HTN22 5     

External Ids:    HGNC: 52841   Entrez Gene: 33472   Ensembl: ENSG000002056497   OMIM: 1427025   UniProtKB: P155163   

Export aliases for HTN3 gene to outside databases

Previous GC identifers: GC04P070804 GC04P070942 GC04P071144 GC04P071209 GC04P071074 GC04P066691


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTN3:
This gene encodes a member of the histatin family of small, histidine-rich salivary proteins. Histatins exhibit
non-immunological, anti-microbial activity in the oral cavity. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
Function: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous
structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits
Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of
metalloproteinases MMP2 and MMP9

Gene Wiki entry for HTN3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTN3 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HTN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13

HTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTN3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P070894:  view genomic region     (about GC identifiers)

Start:
70,894,130 bp from pter      End:
70,902,255 bp from pter
Size:
8,126 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516 (See protein sequence)
Recommended Name: Histatin-3 precursor  
Size: 51 amino acids; 6149 Da
Subunit: His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2
proteins
Subcellular location: Secreted. Note=Secreted by serous acinar and demilune cells
Miscellaneous: The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In
agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions
within the precursor, and not in the mature protein, as has formerly been proposed
Secondary accessions: Q16243 Q502Z1

Explore the universe of human proteins at neXtProt for HTN3: NX_P15516

Post-translational modifications:

  • 24 proteolytic products are found in saliva1
  • View neXtProt modification sites for NX_P15516

  • HTN3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000191.1  
    ENSEMBL proteins: 
     ENSP00000437158   ENSP00000432561   ENSP00000370445  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HTN3
    OriGene Custom Protein Services for HTN3 
    GenScript Custom Purified and Recombinant Proteins Services for HTN3
    Novus Biologicals HTN3 Protein
    Novus Biologicals HTN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HTN3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS3286634


    HTN3 for ontologies           About GeneDecksing



    HTN3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HTN3 
    GenScript Custom Superior Antibodies Services for HTN3
    Novus Biologicals HTN3 Antibody
    Search for Antibodies for HTN3 at Abcam  
    Uscn Antibodies for HTN3
    Search ThermoFisher Antibodies for HTN3

    Assay Products for HTN3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HTN3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HTN3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P15516

    UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
    Similarity: Belongs to the histatin/statherin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
    Function: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous
    structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
    His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits
    Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of
    metalloproteinases MMP2 and MMP9

         Genatlas biochemistry entry for HTN3:
    histatin 3

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTN3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HTN3
    SwitchGear 3'UTR luciferase reporter plasmidHTN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTN3
    OriGene shRNA RFP: HTN3
    OriGene siRNA: HTN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTN3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTN3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HTN3 (NM_000200)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HTN3
    Search LifeMap BioReagents cell lines for HTN3

    In Situ Assay
    Products:
       

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HTN3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--


    HTN3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTN3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for HTN3 (P155162, 3 ENSP000003704454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=2 STRING: ENSP00000302021
    --P954932MINT-8415942 MINT-8415972 MINT-8415994 MINT-8415952 MINT-8415962 MINT-8415984 MINT-8415924
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031214biomineral tissue development IEA--
    GO:0031640killing of cells of other organism IEA--
    GO:0042742defense response to bacterium NAS3286634
    GO:0050832defense response to fungus IEA--


    HTN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTN3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HTN3
    10/23 Novoseek chemical compound relationships for HTN3 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgla 75.6 2 11099499 (1), 11204768 (1)
    anti-fungal 71.9 21 16901460 (3), 11099499 (2), 16919097 (1), 9333052 (1) (see all 16)
    trifluoroethanol 68.1 5 10423240 (2), 9923693 (1), 11454169 (1), 2406266 (1)
    sodium azide 57 3 11816973 (1), 11717389 (1), 10639361 (1)
    miconazole 39.2 2 9333052 (1), 15073161 (1)
    tannins 37.7 15 7575474 (4), 10794615 (2)
    amphotericin b 35.6 6 11204768 (3), 18566844 (1), 15073161 (1)
    hydroxyapatite 28.5 17 16055080 (3), 12711380 (3), 8297263 (2)
    fluconazole 26.4 1 12499171 (1)
    copper 23.8 6 11226423 (3), 17482573 (1), 19846304 (1)

    Search CenterWatch for drugs/clinical trials and news about HTN3 / HIS3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTN3 gene: 
    NM_000200.2  

    Unigene Cluster for HTN3:

    Histatin 3
    Hs.654442  [show with all ESTs]
    Unigene Representative Sequence: CR749410
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526767(uc003hew.2) ENST00000530128 ENST00000528003 ENST00000529625
    ENST00000533547 ENST00000381057

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTN3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HTN3
    SwitchGear 3'UTR luciferase reporter plasmidHTN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTN3
    OriGene shRNA RFP: HTN3
    OriGene siRNA: HTN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTN3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HTN3 (NM_000200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTN3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTN3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTN3

    Additional cDNA sequence: 

    BC009791.1 BC095438.1 CR749410.1 M18372.1 M26665.1 

    24/35 DOTS entries (see all 35):

    DT.100829014  DT.121249549  DT.444397  DT.100829038  DT.121249385  DT.92420462  DT.121249603  DT.100829029 
    DT.121249367  DT.100680399  DT.100744211  DT.100755270  DT.100829023  DT.100829033  DT.100829044  DT.100829048 
    DT.121249380  DT.100755269  DT.100829035  DT.100829045  DT.100741061  DT.100829022  DT.100829028  DT.100829030 

    24/1728 AceView cDNA sequences (see all 1728):

    AA382524 BP334251 BP334022 BP333885 AA376496 AA376688 AA376493 BP334413 
    AA376717 AA376710 BP334484 BP334762 BP334178 AA376712 BP334623 BX486743 
    BP335111 AA376645 BP333958 AA367534 BP334472 BX485098 AA376638 CB986649 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTATGGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HTN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTN3

    SOURCE GeneReport for Unigene cluster: Hs.654442
        SABiosciences Custom PCR Arrays for HTN3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTN3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HTN3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTN3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTN3
    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HTN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for HTN3 (if available)
    TreeFam Gene Tree for HTN3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTN3 gene
    HTN12  
    1 SIMAP similar gene for HTN3 using alignment to 1 protein entry:     HIS3_HUMAN:
    HTN1

    HTN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
    Polymorphism: There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2
    found primarily and in high frequencies in black populations


    10/562 NCBI SNPs in HTN3 are shown (see all 562    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11365111,2
    C,F,H,non-pathogenic66696574(+) ACATCG/AAGGCT 2 /Q /R mis117Minor allele frequency- A:0.05NA NS EA WA CSA EU 6908
    rs171479901,2
    C,F,H,non-pathogenic66696593(+) AATTAA/R/TCTGTA 3 * Y stg119NA NS EA WA CSA EU 7030
    rs561175071,2
    C,--66689898(+) ATGAAT/AGCAGA 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs738260491,2
    C,--66690244(+) TATCAA/GTAGCT 1 -- us2k13Minor allele frequency- G:0.13WA CSA 121
    rs176997151,2
    C,F,H,--66691420(+) GAACGT/CGTAAA 1 -- us2k110Minor allele frequency- C:0.05NA NS 940
    rs171479741,2
    C,--66691732(+) CTTTCC/TGTCTC 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs738260501,2
    C,--66691941(+) TATTAG/CCATAA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs100075231,2
    C,F,H,--66692648(+) AACAAC/TGGTAA 1 -- int15Minor allele frequency- T:0.02NS EA WA 536
    rs757108281,2
    C,F,--66692755(+) ATACAA/GGAAGT 1 -- int11Minor allele frequency- G:0.04NA 120
    rs7768481,2
    F,H,--66692837(+) AGATGT/CAGGGC 1 -- int15Minor allele frequency- C:0.02NS EA WA 524

    HapMap Linkage Disequilibrium report for HTN3 (70894130 - 70902255 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HTN3: --
    Human Gene Mutation Database (HGMD): HTN3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTN3
    DNA2.0 Custom Variant and Variant Library Synthesis for HTN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HTN3 for disorders           About GeneDecksing

    OMIM gene information: 142702    OMIM disorders: --

    14 diseases for HTN3:    About MalaCards
    candida glabrata    sporotrichosis    oral candidiasis    candidiasis
    acrodysostosis    periodontal disease    periodontitis    cystic fibrosis
    hepatitis b    fibrosis    gingivitis    immunodeficiency
    peritonitis    hepatitis

    5 Novoseek disease relationships for HTN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oral candidiasis 67.2 3 12499171 (2), 11083633 (1)
    candidiasis 51.2 2 16940535 (1), 14659657 (1)
    periodontal diseases 37.3 1 15649864 (1)
    aids 11.5 2 16940535 (1), 12499171 (1)
    immunodeficiency 3.31 1 16940535 (1)

    Human Genome Epidemiology (HuGE) Navigator: HTN3 (2 documents)

    Export disorders for HTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTN3 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with HTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PubMed id 15272024)1, 2, 9 Castagnola M....Messana I. (2004)
    2. Zinc and copper bind to unique sites of histatin 5. (PubMed id 11226423)1, 2, 9 Grogan J.... Oppenheim F.G. (2001)
    3. Candidacidal activity of recombinant human salivary histatin-5 and variants. (PubMed id 8945538)1, 2, 9 Tsai H.... Bobek L.A. (1996)
    4. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PubMed id 8336540)1, 2, 9 Chen Z.W. (1993)
    5. Molecular cloning of human submandibular histatins. (PubMed id 2344289)1, 2, 9 Vanderspek J.C.... Oppenheim F.G. (1990)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Immunocytochemical localization of histatins in human salivary glands. (PubMed id 14966203)1, 2 Ahmad M.... Hand A.R. (2004)
    8. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. (PubMed id 12761219)1, 2 Li X.S.... Edgerton M. (2003)
    9. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. (PubMed id 11179305)1, 2 Gusman H....Oppenheim F.G. (2001)
    10. Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant. (PubMed id 7951254)1, 2 Sabatini L.M. and Azen E.A. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3347 HGNC: 5284 AceView: HTN3andHTN1andSTATH Ensembl:ENSG00000205649 euGenes: HUgn3347
    ECgene: HTN3 H-InvDB: HTN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTN3 gene:
    Search GeneIP for patents involving HTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HTN3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTN3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTN3  
     OriGene Protein Over-expression Lysate for HTN3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HTN3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTN3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HTN3   OriGene Custom Protein Services for HTN3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HTN3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTN3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTN3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTN3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTN3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTN3
     GenScript Custom Purified and Recombinant Proteins Services for HTN3 GenScript cDNA clones with any tag delivered in your preferred vector for HTN3
     GenScript Custom Assay Services for HTN3 GenScript Custom Superior Antibodies Services for HTN3
     GenScript Custom overexpressing Cell Line Services for HTN3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HTN3 promoter
     Search Chromatin IP Primers for HTN3
     RT2 qPCR Primer Assay in human, mouse / rat HTN3
     GNC Network for HTN3
     SABiosciences Custom PCR Arrays for HTN3
     Search Tocris compounds for HTN3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HTN3 antibodies
     HTN3 proteins
     HTN3 lysates
     Search for Antibodies for HTN3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HTN3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HTN3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HTN3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HTN3
     SwitchGear 3'UTR luciferase reporter plasmids for HTN3
     SwitchGear Promoter luciferase reporter plasmids for HTN3
     Search ThermoFisher Antibodies for HTN3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTN3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HTN3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4