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Aliases for HTN3 Gene

Aliases for HTN3 Gene

  • Histatin 3 2 3
  • HIS2 3 4 6
  • Basic Histidine-Rich Protein 3 4
  • Histidine-Rich Protein 3 3 4
  • HTN2 3 6
  • HST 3 4
  • PB 3 4
  • Histatin 5 3
  • Histatin-3 3
  • Histatin-4 3
  • Histatin-5 3
  • Histatin-6 3
  • Histatin-7 3
  • Histatin-8 3
  • Histatin-9 3
  • HTN5 3

External Ids for HTN3 Gene

Previous GeneCards Identifiers for HTN3 Gene

  • GC04P070804
  • GC04P070942
  • GC04P071144
  • GC04P071209
  • GC04P071074
  • GC04P066691
  • GC04P070894

Summaries for HTN3 Gene

Entrez Gene Summary for HTN3 Gene

  • This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Sep 2014]

GeneCards Summary for HTN3 Gene

HTN3 (Histatin 3) is a Protein Coding gene. Diseases associated with HTN3 include candida glabrata and oral candidiasis. Among its related pathways are Salivary secretion. An important paralog of this gene is HTN1.

UniProtKB/Swiss-Prot for HTN3 Gene

  • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Gene Wiki entry for HTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN3 Gene

Genomics for HTN3 Gene

Regulatory Elements for HTN3 Gene

Genomic Location for HTN3 Gene

Start:
70,028,413 bp from pter
End:
70,036,538 bp from pter
Size:
8,126 bases
Orientation:
Plus strand

Genomic View for HTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTN3 Gene

Proteins for HTN3 Gene

  • Protein details for HTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15516-HIS3_HUMAN
    Recommended name:
    Histatin-3
    Protein Accession:
    P15516
    Secondary Accessions:
    • Q16243
    • Q502Z1

    Protein attributes for HTN3 Gene

    Size:
    51 amino acids
    Molecular mass:
    6149 Da
    Quaternary structure:
    • His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and SSA2 proteins
    Miscellaneous:
    • The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

neXtProt entry for HTN3 Gene

Proteomics data for HTN3 Gene at MOPED

Post-translational modifications for HTN3 Gene

Other Protein References for HTN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTN3 Gene

Domains for HTN3 Gene

Protein Domains for HTN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HTN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15516

UniProtKB/Swiss-Prot:

HIS3_HUMAN :
  • P15516
Family:
  • Belongs to the histatin/statherin family.
genes like me logo Genes that share domains with HTN3: view

No data available for Gene Families for HTN3 Gene

Function for HTN3 Gene

Molecular function for HTN3 Gene

GENATLAS Biochemistry:
histatin 3
UniProtKB/Swiss-Prot Function:
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9.

Gene Ontology (GO) - Molecular Function for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23499434
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HTN3: view

miRNA for HTN3 Gene

miRTarBase miRNAs that target HTN3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HTN3 Gene

Localization for HTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTN3 Gene

Secreted. Note=Secreted by serous acinar and demilune cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTN3 Gene COMPARTMENTS Subcellular localization image for HTN3 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 3286634
genes like me logo Genes that share ontologies with HTN3: view

Pathways for HTN3 Gene

SuperPathways for HTN3 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with HTN3: view

Pathways by source for HTN3 Gene

1 KEGG pathway for HTN3 Gene

Interacting Proteins for HTN3 Gene

Gene Ontology (GO) - Biological Process for HTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031214 biomineral tissue development IEA --
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium NAS 3286634
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with HTN3: view

Compounds for HTN3 Gene

(23) Novoseek inferred chemical compound relationships for HTN3 Gene

Compound -log(P) Hits PubMed IDs
pgla 75.6 2
anti-fungal 71.9 19
trifluoroethanol 68.1 5
sodium azide 57 3
miconazole 39.2 2
genes like me logo Genes that share compounds with HTN3: view

Transcripts for HTN3 Gene

Unigene Clusters for HTN3 Gene

Histatin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTN3 Gene

No ASD Table

Relevant External Links for HTN3 Gene

GeneLoc Exon Structure for
HTN3
ECgene alternative splicing isoforms for
HTN3

Expression for HTN3 Gene

mRNA expression in normal human tissues for HTN3 Gene

mRNA differential expression in normal tissues according to GTEx for HTN3 Gene

This gene is overexpressed in Pituitary (40.1), Minor Salivary Gland (4.4), and Muscle - Skeletal (4.3).

Protein differential expression in normal tissues for HTN3 Gene

This gene is overexpressed in Saliva (56.2) and Salivary gland (12.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HTN3 Gene

SOURCE GeneReport for Unigene cluster for HTN3 Gene Hs.654442

genes like me logo Genes that share expressions with HTN3: view

Expression partners for HTN3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HTN3 Gene

Orthologs for HTN3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HTN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTN3 35
  • 99.35 (n)
  • 98.04 (a)
HTN3 36
  • 98 (a)
OneToOne
Species with no ortholog for HTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTN3 Gene

ENSEMBL:
Gene Tree for HTN3 (if available)
TreeFam:
Gene Tree for HTN3 (if available)

Paralogs for HTN3 Gene

Paralogs for HTN3 Gene

Selected SIMAP similar genes for HTN3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTN3: view

Variants for HTN3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HTN3 Gene

P15516-HIS3_HUMAN
There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant histatin-3-2 found primarily and in high frequencies in black populations

Sequence variations from dbSNP and Humsavar for HTN3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7654757 -- 70,036,695(+) TCTTA(C/T)AAACA downstream-variant-500B
rs7655359 -- 70,037,001(+) gatgc(C/T)gagca downstream-variant-500B
rs17147996 -- 70,036,918(+) ACAAG(C/T)TTATT downstream-variant-500B
rs73826056 -- 70,036,208(+) GTATA(A/T)ATTTA intron-variant
rs73826057 -- 70,036,362(+) CAATG(A/C)AGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTN3 Gene

Variant ID Type Subtype PubMed ID
dgv5628n71 CNV Loss 21882294
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294
dgv5630n71 CNV Loss 21882294
nsv879463 CNV Loss 21882294

Relevant External Links for HTN3 Gene

HapMap Linkage Disequilibrium report
HTN3
Human Gene Mutation Database (HGMD)
HTN3

Disorders for HTN3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTN3 Gene in MalaCards »

(3) Diseases for HTN3 Gene including...

(5) Novoseek inferred disease relationships for HTN3 Gene

Disease -log(P) Hits PubMed IDs
oral candidiasis 67.2 3
candidiasis 51.2 2
periodontal diseases 37.3 1
aids 11.5 2
immunodeficiency 3.31 1

Relevant External Links for HTN3

Genetic Association Database (GAD)
HTN3
Human Genome Epidemiology (HuGE) Navigator
HTN3
genes like me logo Genes that share disorders with HTN3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HTN3 Gene

Publications for HTN3 Gene

  1. Molecular cloning of human submandibular histatins. (PMID: 2344289) Vanderspek J.C. … Oppenheim F.G. (Arch. Oral Biol. 1990) 3 4 23
  2. Candidacidal activity of recombinant human salivary histatin-5 and variants. (PMID: 8945538) Tsai H. … Bobek L.A. (Infect. Immun. 1996) 3 4 23
  3. Zinc and copper bind to unique sites of histatin 5. (PMID: 11226423) Grogan J. … Oppenheim F.G. (FEBS Lett. 2001) 3 4 23
  4. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PMID: 15272024) Castagnola M. … Messana I. (J. Biol. Chem. 2004) 3 4 23
  5. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Chen Z.W. (Mol. Biol. Evol. 1993) 3 4 23

Products for HTN3 Gene

Sources for HTN3 Gene

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