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HTN3 Gene

protein-coding   GIFtS: 54
GCID: GC04P070894

Histatin 3

  See HTN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histatin 31 2     HTN52
HIS22 3 5     Histatin 52
Basic Histidine-Rich Protein2 3     histatin-32
Histidine-Rich Protein 32 3     hst2
PB2 3     Hst3
HTN22 5     

External Ids:    HGNC: 52841   Entrez Gene: 33472   Ensembl: ENSG000002056497   OMIM: 1427025   UniProtKB: P155163   

Export aliases for HTN3 gene to outside databases

Previous GC identifers: GC04P070804 GC04P070942 GC04P071144 GC04P071209 GC04P071074 GC04P066691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTN3 Gene:
This gene encodes a member of the histatin family of small, histidine-rich salivary proteins. Histatins exhibit
non-immunological, anti-microbial activity in the oral cavity. (provided by RefSeq, May 2009)

GeneCards Summary for HTN3 Gene:
HTN3 (histatin 3) is a protein-coding gene. Diseases associated with HTN3 include candida glabrata, and oral candidiasis. An important paralog of this gene is HTN1.

UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
Function: Histatins are salivary proteins that are considered to be major precursors of the protective
proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and
antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and
C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition,
His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9

Gene Wiki entry for HTN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTN3 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTN3 promoter sequence
   Search Chromatin IP Primers for HTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13

HTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTN3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P070894:  view genomic region     (about GC identifiers)

Start:
70,894,130 bp from pter      End:
70,902,255 bp from pter
Size:
8,126 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516 (See protein sequence)
Recommended Name: Histatin-3 precursor  
Size: 51 amino acids; 6149 Da
Subunit: His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-43)-peptide interact with yeast SSA1 and
SSA2 proteins
Miscellaneous: The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643).
In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the
positions within the precursor, and not in the mature protein, as has formerly been proposed
Secondary accessions: Q16243 Q502Z1

Explore the universe of human proteins at neXtProt for HTN3: NX_P15516

Post-translational modifications: 

  • 24 proteolytic products are found in saliva1
  • Modification sites at neXtProt
  • REFSEQ proteins: NP_000191.1  
    ENSEMBL proteins: 
     ENSP00000437158   ENSP00000432561   ENSP00000370445  

    HTN3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HTN3

     
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    antibodies-online proteins for HTN3 

     
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    antibodies-online antibodies for HTN3 (2 products) 

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    antibodies-online kits for HTN3 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: P15516

    UniProtKB/Swiss-Prot: HIS3_HUMAN, P15516
    Similarity: Belongs to the histatin/statherin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIS3_HUMAN, P15516
    Function: Histatins are salivary proteins that are considered to be major precursors of the protective
    proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and
    antifungal activities. His3-(20-43)-peptide (histatin-5) is especially effective against C.albicans and
    C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition,
    His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9

         Genatlas biochemistry entry for HTN3:
    histatin 3

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with HTN3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HTN3

    miRNA
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    miRTarBase miRNAs that target HTN3:
    hsa-mir-335-5p (MIRT018323)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIS3_HUMAN, P15516: Secreted. Note=Secreted by serous acinar and demilune cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS3286634

    Find genes that share ontologies with HTN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HTN3 About    
    See pathways by source

    SuperPathContained pathways About
    1Salivary secretion
    Salivary secretion0.34


    Find genes that share SuperPaths with HTN3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for HTN3):
        Salivary secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HTN3
    Interactions:

        GeneGlobe Interaction Network for HTN3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for HTN3 (P155161, 2, 3 ENSP000003704454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUC7Q8TAX73, ENSP000003020214I2D: score=2 STRING: ENSP00000302021
    rgpBP954931, 2EBI-738783,EBI-8505881 MINT-8415942 MINT-8415972 MINT-8415994 MINT-8415952 MINT-8415962 MINT-8415984 MINT-8415924
    --P954931, 2EBI-738783,EBI-8505881 MINT-8415942 MINT-8415972 MINT-8415994 MINT-8415952 MINT-8415962 MINT-8415984 MINT-8415924
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031214biomineral tissue development IEA--
    GO:0031640killing of cells of other organism IEA--
    GO:0042742defense response to bacterium NAS3286634
    GO:0050832defense response to fungus IEA--

    Find genes that share ontologies with HTN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HTN3 (HIS3)

    Selected Novoseek inferred chemical compound relationships for HTN3 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pgla 75.6 2 11099499 (1), 11204768 (1)
    anti-fungal 71.9 21 16901460 (3), 11099499 (2), 16919097 (1), 9333052 (1) (see all 16)
    trifluoroethanol 68.1 5 10423240 (2), 9923693 (1), 11454169 (1), 2406266 (1)
    sodium azide 57 3 11816973 (1), 11717389 (1), 10639361 (1)
    miconazole 39.2 2 9333052 (1), 15073161 (1)
    tannins 37.7 15 7575474 (4), 10794615 (2)
    amphotericin b 35.6 6 11204768 (3), 18566844 (1), 15073161 (1)
    hydroxyapatite 28.5 17 16055080 (3), 12711380 (3), 8297263 (2)
    fluconazole 26.4 1 12499171 (1)
    copper 23.8 6 11226423 (3), 17482573 (1), 19846304 (1)



    Find genes that share compounds with HTN3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HTN3 gene: 
    NM_000200.2  

    Unigene Cluster for HTN3:

    Histatin 3
    Hs.654442  [show with all ESTs]
    Unigene Representative Sequence: CR749410
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526767(uc003hew.2) ENST00000530128 ENST00000528003 ENST00000529625
    ENST00000533547 ENST00000381057
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat HTN3

    Additional mRNA sequence: 

    BC009791.1 BC095438.1 CR749410.1 M18372.1 M26665.1 

    Selected DOTS entries (see all 30):

    DT.100829014  DT.121249549  DT.444397  DT.100829038  DT.121249385  DT.92420462  DT.121249603  DT.100829029 
    DT.121249367  DT.100744211  DT.100829023  DT.100829044  DT.100829048  DT.121249380  DT.100755269  DT.100741061 
    DT.100829028  DT.100829030  DT.100829047  DT.121249540  DT.121249556  DT.100680399  DT.100755270  DT.100829012 

    Selected AceView cDNA sequences (see all 1728):

    AA376574 BC017835 BP334352 BP334749 BP334022 AA376493 AA376630 BP334933 
    AA376709 NM_002159 BP334479 AA376496 BP333885 CB958037 BP333771 BP334472 
    BP334762 BP334274 BP333958 BP335090 BP334935 BP334827 AA376638 AA376694 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATGGAGG
    HTN3 Expression
    About this image

    HTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.654442
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for HTN3 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia HTN31 histatin 3 99.35(n)
    98.04(a)
      100610105  XM_003950333.1  XP_003950382.1 


    ENSEMBL Gene Tree for HTN3 (if available)
    TreeFam Gene Tree for HTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTN3 gene
    HTN12  
    1 SIMAP similar gene for HTN3 using alignment to 1 protein entry:     HIS3_HUMAN:
    HTN1

    Find genes that share paralogs with HTN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    HIS3_HUMAN, P15516: There are two alleles of HTN3, HIS2(1) (shown here) and HIS2(2) that codes for the variant
    histatin-3-2 found primarily and in high frequencies in black populations


    Selected SNPs for HTN3 (see all 327)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11365111,2,,4
    C,F,Hnon-pathogenic170772874(+) ACATCG/AAGGCT 2 /Q /R mis117Minor allele frequency- A:0.05NA NS EA WA CSA EU 6908
    rs171479901,2
    C,F,Hnon-pathogenic170772893(+) AATTAT/ACTGTA 2 /* /Y stg119Minor allele frequency- A:0.05NA NS EA WA CSA EU 7030
    rs1859290921,2
    --70766135(+) TTGAGC/TGCTGT 1 -- us2k10--------
    rs1429228151,2
    --70766136(+) TGAGCA/GCTGTA 1 -- us2k10--------
    rs7768451,2
    C,F,H--70766157(+) TCAGTT/AAGCTA 1 -- us2k115Minor allele frequency- A:0.09EA NS NA WA CSA 655
    rs1478089821,2
    --70766172(+) TGCGCC/TACTGC 1 -- us2k10--------
    rs1900376201,2
    --70766192(+) TGGGTG/TATGAA 1 -- us2k10--------
    rs561175071,2
    C,F--70766198(+) ATGAAT/AGCAGA 1 -- us2k12Minor allele frequency- A:0.21WA 120
    rs1412372951,2
    --70766442(+) ACATAG/TCTTTA 1 -- us2k10--------
    rs1812058901,2
    --70766446(+) AGCTTC/TATATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTN3 (70894130 - 70902255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HTN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5630n71CNV Loss21882294
    dgv5629n71CNV Loss21882294
    nsv879463CNV Loss21882294
    dgv5628n71CNV Loss21882294
    nsv879460CNV Gain21882294

    Human Gene Mutation Database (HGMD): HTN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTN3
    DNA2.0 Custom Variant and Variant Library Synthesis for HTN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142702    OMIM disorders: --

    3 diseases for HTN3:    
    About MalaCards
    candida glabrata    oral candidiasis    candidiasis


    Find genes that share disorders with HTN3           About GenesLikeMe

    5 Novoseek inferred disease relationships for HTN3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oral candidiasis 67.2 3 12499171 (2), 11083633 (1)
    candidiasis 51.2 2 16940535 (1), 14659657 (1)
    periodontal diseases 37.3 1 15649864 (1)
    aids 11.5 2 16940535 (1), 12499171 (1)
    immunodeficiency 3.31 1 16940535 (1)

    Genetic Association Database (GAD): HTN3
    Human Genome Epidemiology (HuGE) Navigator: HTN3 (2 documents)

    Export disorders for HTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTN3 gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with HTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. (PubMed id 15272024)1, 2, 9 Castagnola M....Messana I. (J. Biol. Chem. 2004)
    2. Zinc and copper bind to unique sites of histatin 5. (PubMed id 11226423)1, 2, 9 Grogan J.... Oppenheim F.G. (FEBS Lett. 2001)
    3. Candidacidal activity of recombinant human salivary histatin-5 and variants. (PubMed id 8945538)1, 2, 9 Tsai H.... Bobek L.A. (Infect. Immun. 1996)
    4. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PubMed id 8336540)1, 2, 9 Chen Z.W. (Mol. Biol. Evol. 1993)
    5. Molecular cloning of human submandibular histatins. (PubMed id 2344289)1, 2, 9 Vanderspek J.C.... Oppenheim F.G. (Arch. Oral Biol. 1990)
    6. Polymorphism of salivary histatin gene and periodontal disease in the Japanese population. (PubMed id 19753800)1, 4, 9 Fujigaki Y....Wang P.L. (J Int Acad Periodontol 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Immunocytochemical localization of histatins in human salivary glands. (PubMed id 14966203)1, 2 Ahmad M.... Hand A.R. (J. Histochem. Cytochem. 2004)
    9. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. (PubMed id 12761219)1, 2 Li X.S.... Edgerton M. (J. Biol. Chem. 2003)
    10. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. (PubMed id 11179305)1, 2 Gusman H....Oppenheim F.G. (Infect. Immun. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3347 HGNC: 5284 AceView: HTN3andHTN1andSTATH Ensembl:ENSG00000205649 euGenes: HUgn3347
    ECgene: HTN3 Kegg: 3347 H-InvDB: HTN3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for HTN3 gene:
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