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Aliases for HTN1 Gene

Aliases for HTN1 Gene

  • Histatin 1 2 3
  • Histidine-Rich Protein 1 3 4
  • Post-PB Protein 3 4
  • HIS1 3 4
  • PPB 3 4
  • Histatin-1 3

External Ids for HTN1 Gene

Summaries for HTN1 Gene

Entrez Gene Summary for HTN1 Gene

  • This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

GeneCards Summary for HTN1 Gene

HTN1 (Histatin 1) is a Protein Coding gene. Diseases associated with HTN1 include candida glabrata and atypical autism. Among its related pathways are Salivary secretion. An important paralog of this gene is HTN3.

UniProtKB/Swiss-Prot for HTN1 Gene

  • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities

Gene Wiki entry for HTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN1 Gene

Genomics for HTN1 Gene

Genomic Location for HTN1 Gene

70,050,402 bp from pter
70,058,845 bp from pter
8,444 bases
Plus strand

Genomic View for HTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTN1 Gene

Regulatory Elements for HTN1 Gene

Proteins for HTN1 Gene

  • Protein details for HTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for HTN1 Gene

    57 amino acids
    Molecular mass:
    6963 Da
    Quaternary structure:
    No Data Available
    • The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

neXtProt entry for HTN1 Gene

Proteomics data for HTN1 Gene at MOPED

Post-translational modifications for HTN1 Gene

  • Depending on the authors, the form called histatin-2 is alternatively a proteolytic product, or the non-phosphorylated form of histatin-1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTN1 Gene

Domains for HTN1 Gene

Protein Domains for HTN1 Gene



  • Belongs to the histatin/statherin family.:
    • P15515
genes like me logo Genes that share domains with HTN1: view

No data available for Gene Families for HTN1 Gene

Function for HTN1 Gene

Molecular function for HTN1 Gene

GENATLAS Biochemistry: histatin 1 (see SHRP@)
UniProtKB/Swiss-Prot Function: Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities

Gene Ontology (GO) - Molecular Function for HTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
genes like me logo Genes that share ontologies with HTN1: view

Phenotypes for HTN1 Gene

GenomeRNAi human phenotypes for HTN1:
genes like me logo Genes that share phenotypes with HTN1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HTN1 Gene

Localization for HTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTN1 Gene


Subcellular locations from

Jensen Localization Image for HTN1 Gene COMPARTMENTS Subcellular localization image for HTN1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for HTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 3286634
genes like me logo Genes that share ontologies with HTN1: view

Pathways for HTN1 Gene

SuperPathways for HTN1 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with HTN1: view

Pathways by source for HTN1 Gene

1 KEGG pathway for HTN1 Gene

Interacting Proteins for HTN1 Gene

Gene Ontology (GO) - Biological Process for HTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031214 biomineral tissue development IEA --
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium NAS 3286634
GO:0050832 defense response to fungus IEA --
genes like me logo Genes that share ontologies with HTN1: view

Compounds for HTN1 Gene

(4) Novoseek inferred chemical compound relationships for HTN1 Gene

Compound -log(P) Hits PubMed IDs
phosphoserine 58.3 2
hydroxyapatite 49.4 9
serine 8.06 1
zinc 0 2
genes like me logo Genes that share compounds with HTN1: view

Transcripts for HTN1 Gene

mRNA/cDNA for HTN1 Gene

Unigene Clusters for HTN1 Gene

Histatin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -

Relevant External Links for HTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTN1 Gene

mRNA expression in normal human tissues for HTN1 Gene

mRNA differential expression in normal tissues according to GTEx for HTN1 Gene

This gene is overexpressed in Minor Salivary Gland (51.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HTN1 Gene

SOURCE GeneReport for Unigene cluster for HTN1 Gene Hs.250959

mRNA Expression by UniProt/SwissProt for HTN1 Gene

Tissue specificity: Submandibular and parotid glands.
genes like me logo Genes that share expressions with HTN1: view

Orthologs for HTN1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTN1 36
  • 98.25 (n)
  • 96.49 (a)
HTN1 37
  • 96 (a)
Species with no ortholog for HTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTN1 Gene

Gene Tree for HTN1 (if available)
Gene Tree for HTN1 (if available)

Paralogs for HTN1 Gene

Paralogs for HTN1 Gene

Selected SIMAP similar genes for HTN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTN1: view

Variants for HTN1 Gene

Sequence variations from dbSNP and Humsavar for HTN1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1040282 -- 70,049,297(+) AAACA(C/T)AATTT upstream-variant-2KB
rs1040283 -- 70,049,384(+) agagt(C/T)tcctg upstream-variant-2KB
rs1965414 -- 70,050,810(+) tgcag(A/G)acatg intron-variant
rs2009025 -- 70,055,095(-) CTTAC(G/T)TTCCT intron-variant
rs2070718 -- 70,052,804(+) AAAAA(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTN1 Gene

Variant ID Type Subtype PubMed ID
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294
dgv5630n71 CNV Loss 21882294
nsv879463 CNV Loss 21882294
nsv879464 CNV Loss 21882294

Relevant External Links for HTN1 Gene

HapMap Linkage Disequilibrium report

Disorders for HTN1 Gene

(1) University of Copenhagen DISEASES for HTN1 Gene

Relevant External Links for HTN1

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HTN1: view

No data available for UniProtKB/Swiss-Prot for HTN1 Gene

Publications for HTN1 Gene

  1. Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva. (PMID: 2372245) Sugiyama K. … Ogata K. (Arch. Oral Biol. 1990) 3 4 23
  2. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Chen Z.W. (Mol. Biol. Evol. 1993) 3 4 23
  3. Tyrosine polysulfation of human salivary histatin 1. A post- translational modification specific of the submandibular gland. (PMID: 17503797) Cabras T. … Messana I. (J. Proteome Res. 2007) 3 4 23
  4. Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). (PMID: 2719677) Sabatini L.M. … Azen E.A. (Biochem. Biophys. Res. Commun. 1989) 3 4
  5. Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. (PMID: 2773933) Vanderspek J.C. … Troxler R.F. (Am. J. Hum. Genet. 1989) 3 4

Products for HTN1 Gene

Sources for HTN1 Gene

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