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Aliases for HTN1 Gene

Aliases for HTN1 Gene

  • Histatin 1 2 3 5
  • Histidine-Rich Protein 1 3 4
  • Post-PB Protein 3 4
  • HIS1 3 4
  • PPB 3 4

External Ids for HTN1 Gene

Previous GeneCards Identifiers for HTN1 Gene

  • GC04P070826
  • GC04P070964
  • GC04P071166
  • GC04P071231
  • GC04P071096
  • GC04P066713
  • GC04P070916

Summaries for HTN1 Gene

Entrez Gene Summary for HTN1 Gene

  • This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

GeneCards Summary for HTN1 Gene

HTN1 (Histatin 1) is a Protein Coding gene. Diseases associated with HTN1 include Dental Caries and Candida Glabrata. Among its related pathways are Salivary secretion. An important paralog of this gene is HTN3.

UniProtKB/Swiss-Prot for HTN1 Gene

  • Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.

Gene Wiki entry for HTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTN1 Gene

Genomics for HTN1 Gene

Regulatory Elements for HTN1 Gene

Genomic Location for HTN1 Gene

70,050,402 bp from pter
70,058,848 bp from pter
8,447 bases
Plus strand

Genomic View for HTN1 Gene

Genes around HTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTN1 Gene

Proteins for HTN1 Gene

  • Protein details for HTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for HTN1 Gene

    57 amino acids
    Molecular mass:
    6963 Da
    Quaternary structure:
    No Data Available
    • The recommended nomenclature of salivary peptides follows published guidelines (PubMed:20973643). In agreement with the authors, it has been decided to indicate the boundaries of the peptides according to the positions within the precursor, and not in the mature protein, as has formerly been proposed.

neXtProt entry for HTN1 Gene

Proteomics data for HTN1 Gene at MOPED

Post-translational modifications for HTN1 Gene

  • Depending on the authors, the form called histatin-2 is alternatively a proteolytic product, or the non-phosphorylated form of histatin-1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HTN1 Gene

Domains & Families for HTN1 Gene

Gene Families for HTN1 Gene

Protein Domains for HTN1 Gene


Suggested Antigen Peptide Sequences for HTN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histatin/statherin family.
  • Belongs to the histatin/statherin family.
genes like me logo Genes that share domains with HTN1: view

Function for HTN1 Gene

Molecular function for HTN1 Gene

GENATLAS Biochemistry:
histatin 1 (see SHRP@)
UniProtKB/Swiss-Prot Function:
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
genes like me logo Genes that share phenotypes with HTN1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HTN1 Gene

Localization for HTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTN1 Gene


Subcellular locations from

Jensen Localization Image for HTN1 Gene COMPARTMENTS Subcellular localization image for HTN1 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for HTN1 Gene

Pathways & Interactions for HTN1 Gene

SuperPathways for HTN1 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with HTN1: view

Pathways by source for HTN1 Gene

1 KEGG pathway for HTN1 Gene

Interacting Proteins for HTN1 Gene

Gene Ontology (GO) - Biological Process for HTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031640 killing of cells of other organism IEA --
GO:0042742 defense response to bacterium NAS 3286634
genes like me logo Genes that share ontologies with HTN1: view

No data available for SIGNOR curated interactions for HTN1 Gene

Drugs & Compounds for HTN1 Gene

(2) Drugs for HTN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for HTN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HTN1: view

Transcripts for HTN1 Gene

Unigene Clusters for HTN1 Gene

Histatin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: - -

Relevant External Links for HTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTN1 Gene

mRNA expression in normal human tissues for HTN1 Gene

mRNA differential expression in normal tissues according to GTEx for HTN1 Gene

This gene is overexpressed in Minor Salivary Gland (x51.2).

Protein differential expression in normal tissues from HIPED for HTN1 Gene

This gene is overexpressed in Salivary gland (48.3) and Bone marrow mesenchymal stem cell (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTN1 Gene

SOURCE GeneReport for Unigene cluster for HTN1 Gene Hs.250959

mRNA Expression by UniProt/SwissProt for HTN1 Gene

Tissue specificity: Submandibular and parotid glands.
genes like me logo Genes that share expression patterns with HTN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HTN1 Gene

Orthologs for HTN1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for HTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HTN1 35
  • 98.25 (n)
  • 96.49 (a)
HTN1 36
  • 96 (a)
Species with no ortholog for HTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HTN1 Gene

Gene Tree for HTN1 (if available)
Gene Tree for HTN1 (if available)

Paralogs for HTN1 Gene

Paralogs for HTN1 Gene

(1) SIMAP similar genes for HTN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTN1: view

Variants for HTN1 Gene

Sequence variations from dbSNP and Humsavar for HTN1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1040282 -- 70,049,297(+) AAACA(C/T)AATTT upstream-variant-2KB
rs1040283 -- 70,049,384(+) agagt(C/T)tcctg upstream-variant-2KB
rs1965414 -- 70,050,810(+) tgcag(A/G)acatg intron-variant
rs2070718 -- 70,052,804(+) AAAAA(A/G)AAAGA intron-variant
rs2070719 -- 70,053,364(+) AGTAA(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTN1 Gene

Variant ID Type Subtype PubMed ID
dgv5629n71 CNV Loss 21882294
nsv879460 CNV Gain 21882294
dgv5630n71 CNV Loss 21882294
nsv879463 CNV Loss 21882294
nsv879464 CNV Loss 21882294

Variation tolerance for HTN1 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HTN1 Gene

Disorders for HTN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HTN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
candida glabrata
  • torulopsis glabrata
- elite association - COSMIC cancer census association via MalaCards
Search HTN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTN1

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HTN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTN1 Gene

Publications for HTN1 Gene

  1. Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. (PMID: 8336540) Chen Z.W. (Mol. Biol. Evol. 1993) 3 4 23 67
  2. Transcriptional regulation of the salivary histatin gene: finding of a strong positive regulatory element and its binding protein. (PMID: 19060311) Imamura Y. … Wang P.L. (J. Biochem. 2009) 3 23
  3. Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. (PMID: 18650243) Oudhoff M.J. … Veerman E.C. (FASEB J. 2008) 3 23
  4. Tyrosine polysulfation of human salivary histatin 1. A post- translational modification specific of the submandibular gland. (PMID: 17503797) Cabras T. … Messana I. (J. Proteome Res. 2007) 3 23
  5. Two-hybrid analysis of human salivary mucin MUC7 interactions. (PMID: 16203048) Bruno L.S. … Offner G.D. (Biochim. Biophys. Acta 2005) 3 23

Products for HTN1 Gene

Sources for HTN1 Gene