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Aliases for HTATSF1 Gene

Aliases for HTATSF1 Gene

  • HIV-1 Tat Specific Factor 1 2 3
  • HIV TAT Specific Factor 1 2 3
  • TAT-SF1 3 4
  • TATSF1 3 6
  • Cofactor Required For Tat Activation Of HIV-1 Transcription 3
  • HIV Tat-Specific Factor 1 3
  • DJ196E23.2 3

External Ids for HTATSF1 Gene

Summaries for HTATSF1 Gene

Entrez Gene Summary for HTATSF1 Gene

  • The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for HTATSF1 Gene

HTATSF1 (HIV-1 Tat Specific Factor 1) is a Protein Coding gene. Diseases associated with HTATSF1 include hiv-1. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for HTATSF1 Gene

  • Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

Gene Wiki entry for HTATSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTATSF1 Gene

Genomics for HTATSF1 Gene

Genomic Location for HTATSF1 Gene

Start:
136,497,079 bp from pter
End:
136,512,346 bp from pter
Size:
15,268 bases
Orientation:
Plus strand

Genomic View for HTATSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTATSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTATSF1 Gene

Regulatory Elements for HTATSF1 Gene

Proteins for HTATSF1 Gene

  • Protein details for HTATSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43719-HTSF1_HUMAN
    Recommended name:
    HIV Tat-specific factor 1
    Protein Accession:
    O43719
    Secondary Accessions:
    • D3DWG9
    • Q59G06
    • Q99730

    Protein attributes for HTATSF1 Gene

    Size:
    755 amino acids
    Molecular mass:
    85853 Da
    Quaternary structure:
    • Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs).
    SequenceCaution:
    • Sequence=AAB18823.1; Type=Frameshift; Positions=383, 391, 393; Evidence={ECO:0000305}; Sequence=BAD92540.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HTATSF1 Gene

neXtProt entry for HTATSF1 Gene

Proteomics data for HTATSF1 Gene at MOPED

Post-translational modifications for HTATSF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys245 and Lys303

Other Protein References for HTATSF1 Gene

No data available for DME Specific Peptides for HTATSF1 Gene

Domains for HTATSF1 Gene

Gene Families for HTATSF1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HTATSF1 Gene

UniProtKB/Swiss-Prot:

HTSF1_HUMAN
Domain:
  • The RRM domains mediate interaction with U snRNPs.:
    • O43719
  • Contains 2 RRM (RNA recognition motif) domains.:
    • O43719
Family:
  • Belongs to the HTATSF1 family.:
    • O43719
genes like me logo Genes that share domains with HTATSF1: view

Function for HTATSF1 Gene

Molecular function for HTATSF1 Gene

UniProtKB/Swiss-Prot Function: Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

Gene Ontology (GO) - Molecular Function for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HTATSF1: view

Phenotypes for HTATSF1 Gene

GenomeRNAi human phenotypes for HTATSF1:
genes like me logo Genes that share phenotypes with HTATSF1: view

miRNA for HTATSF1 Gene

miRTarBase miRNAs that target HTATSF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HTATSF1 Gene

Localization for HTATSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTATSF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTATSF1 Gene COMPARTMENTS Subcellular localization image for HTATSF1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10454543
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HTATSF1: view

Pathways for HTATSF1 Gene

SuperPathways for HTATSF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10454543
GO:0019079 viral genome replication TAS 10454543
GO:0032784 regulation of DNA-templated transcription, elongation TAS 10454543
genes like me logo Genes that share ontologies with HTATSF1: view

No data available for Pathways by source for HTATSF1 Gene

Transcripts for HTATSF1 Gene

Unigene Clusters for HTATSF1 Gene

HIV-1 Tat specific factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTATSF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for HTATSF1 Gene

GeneLoc Exon Structure for
HTATSF1
ECgene alternative splicing isoforms for
HTATSF1

Expression for HTATSF1 Gene

mRNA expression in normal human tissues for HTATSF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HTATSF1 Gene

SOURCE GeneReport for Unigene cluster for HTATSF1 Gene Hs.204475

mRNA Expression by UniProt/SwissProt for HTATSF1 Gene

O43719-HTSF1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with HTATSF1: view

Orthologs for HTATSF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HTATSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTATSF1 36
  • 99.72 (n)
  • 99.86 (a)
HTATSF1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTATSF1 36
  • 87.01 (n)
  • 83.47 (a)
HTATSF1 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTATSF1 36
  • 85.55 (n)
  • 84.28 (a)
HTATSF1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htatsf1 36
  • 81.45 (n)
  • 76.73 (a)
Htatsf1 16
Htatsf1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HTATSF1 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htatsf1 36
  • 82.35 (n)
  • 76.82 (a)
chicken
(Gallus gallus)
Aves HTATSF1 36
  • 71.38 (n)
  • 70.44 (a)
HTATSF1 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTATSF1 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398736 36
tropical clawed frog
(Silurana tropicalis)
Amphibia htatsf1 36
  • 68.43 (n)
  • 68.62 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11838 36
zebrafish
(Danio rerio)
Actinopterygii htatsf1 36
  • 62.73 (n)
  • 62.54 (a)
htatsf1 37
  • 55 (a)
OneToOne
zgc66252 36
fruit fly
(Drosophila melanogaster)
Insecta barc 37
  • 28 (a)
OneToOne
CG6049 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea Y65B4A.1 37
  • 25 (a)
OneToOne
Y65B4A.1 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUS2 37
  • 30 (a)
OneToOne
CUS2 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3218 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for HTATSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTATSF1 Gene

ENSEMBL:
Gene Tree for HTATSF1 (if available)
TreeFam:
Gene Tree for HTATSF1 (if available)

Paralogs for HTATSF1 Gene

genes like me logo Genes that share paralogs with HTATSF1: view

No data available for Paralogs for HTATSF1 Gene

Variants for HTATSF1 Gene

Sequence variations from dbSNP and Humsavar for HTATSF1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1058376 -- 136,511,008(+) ATGGC(A/G)TTTGA synonymous-codon, reference
rs1203608 -- 136,508,892(+) CAGGG(C/T)AAACC intron-variant
rs2071913 - 136,511,178(-) AGCTG(C/G)CTTCA missense, reference
rs3027836 -- 136,495,622(+) TGGTA(A/G)AGCCG upstream-variant-2KB
rs3027837 -- 136,498,083(+) CTTTT(C/T)TATGC intron-variant

Relevant External Links for HTATSF1 Gene

HapMap Linkage Disequilibrium report
HTATSF1
Human Gene Mutation Database (HGMD)
HTATSF1
Locus Specific Mutation Databases (LSDB)
HTATSF1

No data available for Structural Variations from Database of Genomic Variants (DGV) for HTATSF1 Gene

Disorders for HTATSF1 Gene

(1) MalaCards Diseases for HTATSF1 Gene

Search for HTATSF1 Gene in MalaCards »

Relevant External Links for HTATSF1

Genetic Association Database (GAD)
HTATSF1
Human Genome Epidemiology (HuGE) Navigator
HTATSF1
genes like me logo Genes that share disorders with HTATSF1: view

No data available for UniProtKB/Swiss-Prot for HTATSF1 Gene

Publications for HTATSF1 Gene

  1. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. (PMID: 8849451) Zhou Q. … Sharp P.A. (Science 1996) 2 3 4
  2. Stimulatory effect of splicing factors on transcriptional elongation. (PMID: 11780068) Fong Y.W. … Zhou Q. (Nature 2001) 3 4 23
  3. Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. (PMID: 15564463) Zhou M. … Kumar A. (J. Virol. 2004) 3 23
  4. Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs. (PMID: 19479034) Miller H.B. … Garcia-Blanco M.A. (PLoS ONE 2009) 3 23
  5. Nef triggers a transcriptional program in T cells imitating single- signal T cell activation and inducing HIV virulence mediators. (PMID: 11420046) Simmons A. … McMichael A. (Immunity 2001) 3 4

Products for HTATSF1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • HIV Host Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HTATSF1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HTATSF1
  • Block miRNA regulation of HTATSF1 using miScript Target Protectors

Sources for HTATSF1 Gene

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