Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HTATSF1 Gene

Aliases for HTATSF1 Gene

  • HIV-1 Tat Specific Factor 1 2 3 5
  • HIV TAT Specific Factor 1 2 3
  • TAT-SF1 3 4
  • Cofactor Required For Tat Activation Of HIV-1 Transcription 3
  • HIV Tat-Specific Factor 1 3
  • DJ196E23.2 3
  • TATSF1 3

External Ids for HTATSF1 Gene

Previous GeneCards Identifiers for HTATSF1 Gene

  • GC0XP130151
  • GC0XP132425
  • GC0XP133524
  • GC0XP134285
  • GC0XP135305
  • GC0XP135406
  • GC0XP135579
  • GC0XP124849

Summaries for HTATSF1 Gene

Entrez Gene Summary for HTATSF1 Gene

  • The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

GeneCards Summary for HTATSF1 Gene

HTATSF1 (HIV-1 Tat Specific Factor 1) is a Protein Coding gene. Diseases associated with HTATSF1 include Hiv-1. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for HTATSF1 Gene

  • Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

Gene Wiki entry for HTATSF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTATSF1 Gene

Genomics for HTATSF1 Gene

Regulatory Elements for HTATSF1 Gene

Enhancers for HTATSF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG136495 1 ENCODE 0.7 +0.3 290 2.6 FOXA2 ATF1 CREB3L1 SIN3A ZNF2 YY1 GTF3C2 GLIS2 KLF7 KLF13 SRRM1P3 LOC100420958 MAP7D3 HTATSF1 VGLL1
GH0XG136549 0.3 FANTOM5 1.9 +52.5 52485 0.2 HTATSF1 MIR934 VGLL1
GH0XG136858 0.3 FANTOM5 1.4 +361.7 361662 0.2 HTATSF1 ENSG00000232611 GC0XM136880 GC0XM136881 SNORD61
GH0XG136499 0.4 Ensembl 0.7 +2.4 2369 0.2 ZNF157 HTATSF1 VGLL1
GH0XG136525 0.8 Ensembl ENCODE 0.3 +29.3 29291 1.1 JUND MAFG FOS NFE2 MIR934 VGLL1 HTATSF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTATSF1 on UCSC Golden Path with GeneCards custom track

Promoters for HTATSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249068 668 2800 FOXA2 ATF1 CREB3L1 SIN3A ZNF2 YY1 GTF3C2 GLIS2 KLF7 KLF13

Genomic Location for HTATSF1 Gene

Chromosome:
X
Start:
136,496,932 bp from pter
End:
136,512,346 bp from pter
Size:
15,415 bases
Orientation:
Plus strand

Genomic View for HTATSF1 Gene

Genes around HTATSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTATSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTATSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTATSF1 Gene

Proteins for HTATSF1 Gene

  • Protein details for HTATSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43719-HTSF1_HUMAN
    Recommended name:
    HIV Tat-specific factor 1
    Protein Accession:
    O43719
    Secondary Accessions:
    • D3DWG9
    • Q59G06
    • Q99730

    Protein attributes for HTATSF1 Gene

    Size:
    755 amino acids
    Molecular mass:
    85853 Da
    Quaternary structure:
    • Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs).
    SequenceCaution:
    • Sequence=AAB18823.1; Type=Frameshift; Positions=383, 391, 393; Evidence={ECO:0000305}; Sequence=BAD92540.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HTATSF1 Gene

neXtProt entry for HTATSF1 Gene

Post-translational modifications for HTATSF1 Gene

  • Ubiquitination at isoforms=245 and isoforms=303
  • Modification sites at PhosphoSitePlus

Other Protein References for HTATSF1 Gene

No data available for DME Specific Peptides for HTATSF1 Gene

Domains & Families for HTATSF1 Gene

Gene Families for HTATSF1 Gene

Suggested Antigen Peptide Sequences for HTATSF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43719

UniProtKB/Swiss-Prot:

HTSF1_HUMAN :
  • The RRM domains mediate interaction with U snRNPs.
  • Belongs to the HTATSF1 family.
Domain:
  • The RRM domains mediate interaction with U snRNPs.
Family:
  • Belongs to the HTATSF1 family.
genes like me logo Genes that share domains with HTATSF1: view

Function for HTATSF1 Gene

Molecular function for HTATSF1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.

Gene Ontology (GO) - Molecular Function for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
genes like me logo Genes that share ontologies with HTATSF1: view
genes like me logo Genes that share phenotypes with HTATSF1: view

Animal Model Products

miRNA for HTATSF1 Gene

miRTarBase miRNAs that target HTATSF1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTATSF1 Gene

Localization for HTATSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTATSF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTATSF1 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10454543
GO:0005654 nucleoplasm IDA --
GO:0005684 U2-type spliceosomal complex IBA --
GO:0005686 U2 snRNP IBA --
genes like me logo Genes that share ontologies with HTATSF1: view

Pathways & Interactions for HTATSF1 Gene

SuperPathways for HTATSF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HTATSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 10454543
GO:0019079 viral genome replication TAS 10454543
genes like me logo Genes that share ontologies with HTATSF1: view

No data available for Pathways by source and SIGNOR curated interactions for HTATSF1 Gene

Transcripts for HTATSF1 Gene

Unigene Clusters for HTATSF1 Gene

HIV-1 Tat specific factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTATSF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for HTATSF1 Gene

GeneLoc Exon Structure for
HTATSF1
ECgene alternative splicing isoforms for
HTATSF1

Expression for HTATSF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTATSF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HTATSF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.0), Nasal epithelium (11.0), and Blymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HTATSF1 Gene



Protein tissue co-expression partners for HTATSF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTATSF1 Gene:

HTATSF1

SOURCE GeneReport for Unigene cluster for HTATSF1 Gene:

Hs.204475

mRNA Expression by UniProt/SwissProt for HTATSF1 Gene:

O43719-HTSF1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for HTATSF1 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Kidney(2.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with HTATSF1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HTATSF1 Gene

Orthologs for HTATSF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HTATSF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTATSF1 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia HTATSF1 34 35
  • 87.01 (n)
dog
(Canis familiaris)
Mammalia HTATSF1 34 35
  • 85.55 (n)
rat
(Rattus norvegicus)
Mammalia Htatsf1 34
  • 82.35 (n)
mouse
(Mus musculus)
Mammalia Htatsf1 34 16 35
  • 81.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HTATSF1 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves HTATSF1 34 35
  • 71.38 (n)
lizard
(Anolis carolinensis)
Reptilia HTATSF1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htatsf1 34
  • 68.43 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398736 34
zebrafish
(Danio rerio)
Actinopterygii htatsf1 34 35
  • 62.73 (n)
zgc66252 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11838 34
fruit fly
(Drosophila melanogaster)
Insecta CG6049 36
  • 44 (a)
barc 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y65B4A.1 36 35
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CUS2 35 37
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3218 34
Species where no ortholog for HTATSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTATSF1 Gene

ENSEMBL:
Gene Tree for HTATSF1 (if available)
TreeFam:
Gene Tree for HTATSF1 (if available)

Paralogs for HTATSF1 Gene

genes like me logo Genes that share paralogs with HTATSF1: view

No data available for Paralogs for HTATSF1 Gene

Variants for HTATSF1 Gene

Sequence variations from dbSNP and Humsavar for HTATSF1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000116066 -- 136,500,953(+) AGTTA(C/G)TACCT intron-variant
rs1000345936 -- 136,506,182(+) AGCTT(A/G)ACAAA intron-variant
rs1000483190 -- 136,505,741(+) AAGAT(C/T)GCGCC intron-variant
rs1000785701 -- 136,496,011(+) CACTG(C/G)AATAG upstream-variant-2KB
rs1000926116 -- 136,497,278(+) CTGAG(C/T)AGGGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HTATSF1 Gene

Variant ID Type Subtype PubMed ID
esv3577408 CNV gain 25503493
esv3577409 CNV gain 25503493

Variation tolerance for HTATSF1 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTATSF1 Gene

Human Gene Mutation Database (HGMD)
HTATSF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTATSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTATSF1 Gene

Disorders for HTATSF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HTATSF1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HTATSF1

Genetic Association Database (GAD)
HTATSF1
Human Genome Epidemiology (HuGE) Navigator
HTATSF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTATSF1
genes like me logo Genes that share disorders with HTATSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTATSF1 Gene

Publications for HTATSF1 Gene

  1. Stimulatory effect of splicing factors on transcriptional elongation. (PMID: 11780068) Fong Y.W. … Zhou Q. (Nature 2001) 3 4 22 64
  2. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. (PMID: 8849451) Zhou Q. … Sharp P.A. (Science 1996) 2 3 4 64
  3. Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs. (PMID: 19479034) Miller H.B. … Garcia-Blanco M.A. (PLoS ONE 2009) 3 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64

Products for HTATSF1 Gene

Sources for HTATSF1 Gene

Content
Loading form....