Aliases for HTATSF1 Gene
External Ids for HTATSF1 Gene
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]
GeneCards Summary for HTATSF1 Gene
HTATSF1 (HIV-1 Tat Specific Factor 1) is a Protein Coding gene. Diseases associated with HTATSF1 include hiv-1. GO annotations related to this gene include RNA binding and nucleotide binding.
UniProtKB/Swiss-Prot for HTATSF1 Gene
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.