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HTATSF1 Gene

protein-coding   GIFtS: 58
GCID: GC0XP135579

HIV-1 Tat Specific Factor 1

(Previous name: HIV TAT specific factor 1)
  See HTATSF1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HIV-1 Tat Specific Factor 11 2     Cofactor Required For Tat Activation Of HIV-1 Transcription2
HIV TAT Specific Factor 11 2     dJ196E23.22
TATSF12 5     HIV Tat-Specific Factor 12
TAT-SF12     Tat-SF13

External Ids:    HGNC: 52761   Entrez Gene: 273362   Ensembl: ENSG000001022417   OMIM: 3003465   UniProtKB: O437193   

Export aliases for HTATSF1 gene to outside databases

Previous GC identifers: GC0XP130151 GC0XP132425 GC0XP133524 GC0XP134285 GC0XP135305 GC0XP135406 GC0XP124849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTATSF1 Gene:
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by
HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a
dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation.
Alternatively spliced transcript variants have been found for this gene.(provided by RefSeq, Sep 2009)

GeneCards Summary for HTATSF1 Gene:
HTATSF1 (HIV-1 Tat specific factor 1) is a protein-coding gene. Diseases associated with HTATSF1 include hiv-1. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: HTSF1_HUMAN, O43719
Function: Functions as a general transcription factor playing a role in the process of transcriptional elongation.
May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by
HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced
transcription of the virus

Gene Wiki entry for HTATSF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTATSF1 gene promoter:
         Pbx1a   STAT5A   Evi-1   Gfi-1   c-Rel   PPAR-gamma1   FOXC1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTATSF1 promoter sequence
   Search Chromatin IP Primers for HTATSF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTATSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

HTATSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTATSF1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP135579:  view genomic region     (about GC identifiers)

Start:
135,579,238 bp from pter      End:
135,594,505 bp from pter
Size:
15,268 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HTSF1_HUMAN, O43719 (See protein sequence)
Recommended Name: HIV Tat-specific factor 1  
Size: 755 amino acids; 85853 Da
Subunit: Component of a complex which is at least composed of HTATSF1/Tat-SF1, the P-TEFb complex components CDK9
and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin. Interacts with GTF2F2/RAP30 and POLR2A. Interacts with
TCERG1/CA150. Interacts with SF3A2/SAP62 and the spliceosomal U small nuclear ribonucleoproteins (snRNPs)
Sequence caution: Sequence=AAB18823.1; Type=Frameshift; Positions=383, 391, 393; Sequence=BAD92540.1;
Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for HTATSF1:
2DIT (3D)    
Secondary accessions: D3DWG9 Q59G06 Q99730

Explore the universe of human proteins at neXtProt for HTATSF1: NX_O43719

Explore proteomics data for HTATSF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245, Lys303
  • Modification sites at PhosphoSitePlus

  • See HTATSF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156752.1  NP_055315.2  

    ENSEMBL proteins: 
     ENSP00000411381   ENSP00000412420   ENSP00000218364   ENSP00000442699  

    HTATSF1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O43719

    ProtoNet protein and cluster: O43719

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: HTSF1_HUMAN, O43719
    Domain: The RRM domains mediate interaction with U snRNPs
    Similarity: Belongs to the HTATSF1 family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with HTATSF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HTSF1_HUMAN, O43719
    Function: Functions as a general transcription factor playing a role in the process of transcriptional elongation.
    May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by
    HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced
    transcription of the virus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HTATSF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HTATSF1:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTATSF1
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    miRTarBase miRNAs that target HTATSF1:
    hsa-mir-877-3p (MIRT036920)

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    2 qRT-PCR Assays for microRNAs that regulate HTATSF1:
    hsa-miR-7-1* hsa-miR-7-2*
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HTSF1_HUMAN, O43719: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with HTATSF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HTATSF1: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTATSF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTATSF1 (O437192, 3 ENSP000002183644) via UniProtKB, MINT, STRING, and/or I2D (see all 625)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206124 I2D: score=4 STRING: ENSP00000221494
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 I2D: score=2 STRING: ENSP00000221448
    SNRPB2P085792, 3, ENSP000002460714MINT-7945693 I2D: score=2 STRING: ENSP00000246071
    CCNT1O605632, 3, ENSP000002619004MINT-7945693 I2D: score=1 STRING: ENSP00000261900
    ZNF512BQ96KM62, 3MINT-60795 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10454543
    GO:0019079viral genome replication TAS10454543
    GO:0032784regulation of DNA-templated transcription, elongation TAS10454543

    Find genes that share ontologies with HTATSF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HTATSF1 (HTSF1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HTATSF1 gene (2 alternative transcripts): 
    NM_001163280.1  NM_014500.4  

    Unigene Cluster for HTATSF1:

    HIV-1 Tat specific factor 1
    Hs.204475  [show with all ESTs]
    Unigene Representative Sequence: NM_001163280
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448450 ENST00000425695 ENST00000218364(uc004ezx.3) ENST00000535601(uc004ezw.3)

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate HTATSF1:
    hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidHTATSF1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for HTATSF1 
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    OriGene qPCR primer pairs and template standards for HTATSF1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTATSF1
      QuantiTect SYBR Green Assays in human, mouse, rat HTATSF1
      QuantiFast Probe-based Assays in human, mouse, rat HTATSF1

    Additional mRNA sequence: 

    AB209303.1 AK225870.1 AK299403.1 BC009896.2 BT006886.1 U76992.1 

    11 DOTS entries:

    DT.215426  DT.92443441  DT.92443426  DT.95173876  DT.100816512  DT.75192416  DT.102831969  DT.102831971 
    DT.86855551  DT.95173873  DT.100816516 

    Selected AceView cDNA sequences (see all 193):

    BQ719792 AU142741 AI668767 BU186796 BC009896 BQ431193 AW750102 BG163815 
    CD108522 BU608260 AI401290 AL535692 AI074508 BM784531 BM352032 AI767987 
    BE891981 BG675744 AA629738 BE464008 BE463411 AI670885 AA306098 AI433897 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HTATSF1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:              -                             -                                                                     
    SP2:                                            -                                                                     
    SP3:              -     -                       -                                                                     
    SP4:              -     -     -                 -                                                                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for HTATSF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTATSF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAATAATA
    HTATSF1 Expression
    About this image

    HTATSF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTATSF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.204475

    UniProtKB/Swiss-Prot: HTSF1_HUMAN, O43719
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including HTATSF1: 
              HIV Host Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTATSF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HTATSF1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htatsf11 , 5 HIV TAT specific factor 11, 5 81.45(n)1
    76.73(a)1
      X (30.81 cM)5
    724591  NM_029371.11  NP_083647.11 
     570535835 
    chicken
    (Gallus gallus)
    Aves HTATSF11 HIV-1 Tat specific factor 1 71.38(n)
    70.44(a)
      422245  XM_001233031.3  XP_001233032.1 
    lizard
    (Anolis carolinensis)
    Reptilia HTATSF16
    HIV-1 Tat specific factor 1
    61(a)
    1 ↔ 1
    GL343562.1(152393-162377)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3987362 hypothetical protein LOC398736 76.85(n)    BC059346.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662522 similar to HIV TAT specific factor 1 75.31(n)   394178  BC055565.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60493 RNA binding 44(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y65B4A.13   -- 38(a)   I(654131-658647)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CUS2(YNL286W)4 Protein that binds to U2 snRNA and Prp11p, may be involved more   --   14(95223-96080) 855430  NP_014113.1 


    ENSEMBL Gene Tree for HTATSF1 (if available)
    TreeFam Gene Tree for HTATSF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HTATSF1 gene

    Find genes that share paralogs with HTATSF1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HTATSF1 (see all 8)
    PGOHUM00000243042 PGOHUM00000243593 PGOHUM00000245415 PGOHUM00000236896 PGOHUM00000243031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTATSF1 (see all 231)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928249381,2
    --135535691(+) GAGTTA/GTTCTA 1 -- us2k10--------
    rs1857044501,2
    --135535867(+) CTTCTC/TCGCTG 1 -- us2k10--------
    rs1893133221,2
    --135535916(+) AGCAGG/TCCTCT 1 -- us2k10--------
    rs1810025761,2
    --135536167(+) CGGTTA/GTGGTA 2 -- us2k10--------
    rs30278361,2
    C,H--135536173(+) TGGTAG/AAGCCG 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs2021660371,2
    C--135536428(+) AATTT-/AAAAAA 2 -- us2k10--------
    rs1835499181,2
    --135536429(+) AATTTA/TAAAAA 2 -- us2k10--------
    rs1880405461,2
    --135536670(+) GTATTG/TTTTAA 2 -- us2k10--------
    rs1814451791,2
    C--135536736(+) TTTTTG/TGGGGT 2 -- us2k10--------
    rs1861880011,2
    --135536769(+) GGACCG/TGGAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTATSF1 (135579238 - 135594505 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HTATSF1: --
    Locus Specific Mutation Databases (LSDB): HTATSF1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300346    OMIM disorders: --

    1 disease for HTATSF1:    
    About MalaCards
    hiv-1


    Find genes that share disorders with HTATSF1           About GenesLikeMe

    Genetic Association Database (GAD): HTATSF1
    Human Genome Epidemiology (HuGE) Navigator: HTATSF1 (1 document)

    Export disorders for HTATSF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTATSF1 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with HTATSF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. (PubMed id 8849451)1, 2, 3 Zhou Q. and Sharp P.A. (Science 1996)
    2. Stimulatory effect of splicing factors on transcriptional elongation. (PubMed id 11780068)1, 2, 9 Fong Y.W. and Zhou Q. (Nature 2001)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression. (PubMed id 15905670)1, 2 Misse D.... Veas F. (AIDS 2005)
    6. FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. (PubMed id 15485897)1, 2 Smith M.J.... Pawson T. (Mol. Cell. Biol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Nef triggers a transcriptional program in T cells imitating single- signal T cell activation and inducing HIV virulence mediators. (PubMed id 11420046)1, 2 Simmons A.... McMichael A. (Immunity 2001)
    9. Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. (PubMed id 10913173)1, 2 Fong Y.W. and Zhou Q. (Mol. Cell. Biol. 2000)
    10. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. (PubMed id 10454543)1, 2 Kim J.B.... Sharp P.A. (Mol. Cell. Biol. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27336 HGNC: 5276 AceView: HTATSF1 Ensembl:ENSG00000102241 euGenes: HUgn27336
    ECgene: HTATSF1 H-InvDB: HTATSF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTATSF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTATSF1 gene:
    Search GeneIP for patents involving HTATSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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