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Aliases for HTATIP2 Gene

Aliases for HTATIP2 Gene

  • HIV-1 Tat Interactive Protein 2, 30kDa 2 3
  • TIP30 3 4 6
  • CC3 3 4 6
  • 30 KDa HIV-1 TAT-Interacting Protein 3 4
  • HIV-1 TAT-Interactive Protein 2 3 4
  • Tat-Interacting Protein (30kD) 2 3
  • Short Chain Dehydrogenase/Reductase Family 44U, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 44U 2
  • HIV-1 Tat Interactive Protein 2, 30 KDa 2
  • Oxidoreductase HTATIP2 3
  • EC 1.1.1.- 4
  • Member 1 2
  • EC 1.1.1 64
  • SDR44U1 3

External Ids for HTATIP2 Gene

Summaries for HTATIP2 Gene

GeneCards Summary for HTATIP2 Gene

HTATIP2 (HIV-1 Tat Interactive Protein 2, 30kDa) is a Protein Coding gene. Diseases associated with HTATIP2 include hiv-1 and gnathodiaphyseal dysplasia. GO annotations related to this gene include transcription coactivator activity and oxidoreductase activity.

UniProtKB/Swiss-Prot for HTATIP2 Gene

  • Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Gene Wiki entry for HTATIP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTATIP2 Gene

Genomics for HTATIP2 Gene

Genomic Location for HTATIP2 Gene

Start:
20,363,685 bp from pter
End:
20,383,783 bp from pter
Size:
20,099 bases
Orientation:
Plus strand

Genomic View for HTATIP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTATIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTATIP2 Gene

Regulatory Elements for HTATIP2 Gene

Transcription factor binding sites by QIAGEN in the HTATIP2 gene promoter:

Proteins for HTATIP2 Gene

  • Protein details for HTATIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUP3-HTAI2_HUMAN
    Recommended name:
    Oxidoreductase HTATIP2
    Protein Accession:
    Q9BUP3
    Secondary Accessions:
    • A8K7S7
    • D3DQY8
    • O15383
    • O60520
    • O95345
    • Q53GC1
    • Q53GG2
    • Q6IBI3

    Protein attributes for HTATIP2 Gene

    Size:
    242 amino acids
    Molecular mass:
    27049 Da
    Quaternary structure:
    • Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus. Binds the activation domain of HIV-1 Tat

    Three dimensional structures from OCA and Proteopedia for HTATIP2 Gene

    Alternative splice isoforms for HTATIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTATIP2 Gene

Proteomics data for HTATIP2 Gene at MOPED

Post-translational modifications for HTATIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36 and Lys137

Domains for HTATIP2 Gene

Gene Families for HTATIP2 Gene

HGNC:
  • SDRA :Short chain dehydrogenase/reductase superfamily / Atypical members

Protein Domains for HTATIP2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HTAI2_HUMAN
Domain:
  • Unique C-terminus confers high proteasome-dependent instability to isoform 2.:
    • Q9BUP3
genes like me logo Genes that share domains with HTATIP2: view

Function for HTATIP2 Gene

Molecular function for HTATIP2 Gene

UniProtKB/Swiss-Prot Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Enzyme Numbers (IUBMB) for HTATIP2 Gene

Gene Ontology (GO) - Molecular Function for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9482853
GO:0005515 protein binding IPI 15282309
GO:0016491 oxidoreductase activity IEA --
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor --
GO:0051287 NAD binding --
genes like me logo Genes that share ontologies with HTATIP2: view
genes like me logo Genes that share phenotypes with HTATIP2: view

miRNA for HTATIP2 Gene

miRTarBase miRNAs that target HTATIP2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HTATIP2 Gene

Localization for HTATIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTATIP2 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTATIP2 Gene COMPARTMENTS Subcellular localization image for HTATIP2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
endoplasmic reticulum 2
endosome 1

Gene Ontology (GO) - Cellular Components for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9482853
GO:0005635 nuclear envelope IDA 15282309
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HTATIP2: view

Pathways for HTATIP2 Gene

SuperPathways for HTATIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9482853
GO:0006915 apoptotic process IEA --
GO:0016032 viral process IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HTATIP2: view

No data available for Pathways by source for HTATIP2 Gene

Compounds for HTATIP2 Gene

(1) HMDB Compounds for HTATIP2 Gene

Compound Synonyms Cas Number PubMed IDs
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
genes like me logo Genes that share compounds with HTATIP2: view

Transcripts for HTATIP2 Gene

Unigene Clusters for HTATIP2 Gene

HIV-1 Tat interactive protein 2, 30kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTATIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for HTATIP2 Gene

GeneLoc Exon Structure for
HTATIP2
ECgene alternative splicing isoforms for
HTATIP2

Expression for HTATIP2 Gene

mRNA expression in normal human tissues for HTATIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTATIP2 Gene

This gene is overexpressed in Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HTATIP2 Gene

SOURCE GeneReport for Unigene cluster for HTATIP2 Gene Hs.90753

mRNA Expression by UniProt/SwissProt for HTATIP2 Gene

Q9BUP3-HTAI2_HUMAN
Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.
genes like me logo Genes that share expressions with HTATIP2: view

Orthologs for HTATIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HTATIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTATIP2 36
  • 99.64 (n)
  • 99.28 (a)
HTATIP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HTATIP2 36
  • 91.6 (n)
  • 94.21 (a)
HTATIP2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTATIP2 36
  • 88.98 (n)
  • 90.5 (a)
HTATIP2 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htatip2 36
  • 86.61 (n)
  • 89.34 (a)
Htatip2 16
Htatip2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HTATIP2 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTATIP2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htatip2 36
  • 85.11 (n)
  • 88.51 (a)
chicken
(Gallus gallus)
Aves HTATIP2 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTATIP2 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24303 36
tropical clawed frog
(Silurana tropicalis)
Amphibia htatip2 36
  • 66.96 (n)
  • 69 (a)
Str.6467 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
htatip2 36
  • 64.48 (n)
  • 65.5 (a)
htatip2 37
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C33F10.14 36
  • 52.46 (n)
  • 44.21 (a)
C33F10.14 37
  • 39 (a)
OneToOne
C33F10.4 38
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP52 37
  • 28 (a)
OneToOne
Species with no ortholog for HTATIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTATIP2 Gene

ENSEMBL:
Gene Tree for HTATIP2 (if available)
TreeFam:
Gene Tree for HTATIP2 (if available)

Paralogs for HTATIP2 Gene

No data available for Paralogs for HTATIP2 Gene

Variants for HTATIP2 Gene

Sequence variations from dbSNP and Humsavar for HTATIP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14222 -- 20,383,161(+) ACAAG(C/G)CCATC missense, reference
rs14273 -- 20,367,237(+) ATGAT(G/T)TTGGA reference, missense
rs931643 -- 20,363,104(-) CCTTC(C/T)ACACC upstream-variant-2KB
rs1051776 -- 20,383,035(+) GAAAG(C/T)TCTTT missense, reference
rs1497685 -- 20,368,341(-) GCCCA(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HTATIP2 Gene

Variant ID Type Subtype PubMed ID
nsv469939 CNV Gain 18288195
nsv467720 CNV Gain 19166990
nsv832083 CNV Gain 17160897
nsv7702 CNV Insertion 18451855

Relevant External Links for HTATIP2 Gene

HapMap Linkage Disequilibrium report
HTATIP2

Disorders for HTATIP2 Gene

(3) Novoseek inferred disease relationships for HTATIP2 Gene

Disease -log(P) Hits PubMed IDs
small cell lung cancer 60 1
metastasis 45.4 17
tumors 21.6 17
genes like me logo Genes that share disorders with HTATIP2: view

No data available for UniProtKB/Swiss-Prot for HTATIP2 Gene

Publications for HTATIP2 Gene

  1. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. (PMID: 9174052) Shtivelman E. (Oncogene 1997) 2 3 4 23
  2. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. (PMID: 10611237) Whitman S. … Shtivelman E. (Mol. Cell. Biol. 2000) 3 4 23
  3. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. (PMID: 9482853) Xiao H. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  4. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. (PMID: 11313954) NicAmhlaoibh R. … Shtivelman E. (Oncogene 2001) 3 4 23
  5. TIP30 deficiency increases susceptibility to tumorigenesis. (PMID: 14695192) Ito M. … Xiao H. (Cancer Res. 2003) 3 4 23

Products for HTATIP2 Gene

Sources for HTATIP2 Gene

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