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Aliases for HTATIP2 Gene

Aliases for HTATIP2 Gene

  • HIV-1 Tat Interactive Protein 2 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 44U, Member 1 2 3
  • HIV-1 Tat Interactive Protein 2, 30kDa 2 3
  • 30 KDa HIV-1 TAT-Interacting Protein 3 4
  • HIV-1 TAT-Interactive Protein 2 3 4
  • Tat-Interacting Protein (30kD) 2 3
  • TIP30 3 4
  • CC3 3 4
  • HIV-1 Tat Interactive Protein 2, 30 KDa 2
  • Oxidoreductase HTATIP2 3
  • EC 1.1.1.- 4
  • EC 1.1.1 58
  • SDR44U1 3

External Ids for HTATIP2 Gene

Previous GeneCards Identifiers for HTATIP2 Gene

  • GC11P021546
  • GC11P021329
  • GC11P020424
  • GC11P020349
  • GC11P020341
  • GC11P020068

Summaries for HTATIP2 Gene

GeneCards Summary for HTATIP2 Gene

HTATIP2 (HIV-1 Tat Interactive Protein 2) is a Protein Coding gene. Diseases associated with HTATIP2 include Hiv-1 and Hepatocellular Carcinoma. Among its related pathways are Cytoskeletal Signaling and Apoptosis and Autophagy. GO annotations related to this gene include oxidoreductase activity and NAD binding.

UniProtKB/Swiss-Prot for HTATIP2 Gene

  • Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Gene Wiki entry for HTATIP2 Gene

Additional gene information for HTATIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTATIP2 Gene

Genomics for HTATIP2 Gene

Regulatory Elements for HTATIP2 Gene

Enhancers for HTATIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H020362 1 ENCODE 74.2 +0.6 612 3.2 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 TCF12 GATA2 ATF7 SP3 HTATIP2 PRMT3
GH11H020360 1 Ensembl ENCODE 61.3 -2.8 -2841 1.2 IRF2 L3MBTL2 NFYC ZMYM3 USF2 ELF1 ZBTB40 CHAMP1 KAT8 MEF2D HTATIP2 GC11P020361 GC11P020319
GH11H020366 1.2 Ensembl ENCODE 44.9 +4.3 4330 3.5 PKNOX1 ATF1 ARNT BRCA1 GATA2 ATF7 FOS NCOA1 JUNB TSHZ1 HTATIP2 SLC6A5 PRMT3
GH11H020386 1.1 ENCODE 29.5 +24.3 24338 3.3 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 CBX5 ZNF143 ZNF207 HTATIP2 PRMT3 LOC105376584
GH11H020458 1 ENCODE 21.3 +95.9 95863 1.3 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 SMARCB1 ZNF592 HTATIP2 PRMT3 LOC105376584
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTATIP2 on UCSC Golden Path with GeneCards custom track

Promoters for HTATIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000037859 215 1001 HDGF ATF1 ARNT SIN3A YY1 TCF12 GATA2 ZNF143 ATF7 SP3

Transcription factor binding sites by QIAGEN in the HTATIP2 gene promoter:

Genomic Locations for HTATIP2 Gene

Genomic Locations for HTATIP2 Gene
chr11:20,363,685-20,383,783
(GRCh38/hg38)
Size:
20,099 bases
Orientation:
Plus strand
chr11:20,385,231-20,405,329
(GRCh37/hg19)

Genomic View for HTATIP2 Gene

Genes around HTATIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTATIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTATIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTATIP2 Gene

Proteins for HTATIP2 Gene

  • Protein details for HTATIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUP3-HTAI2_HUMAN
    Recommended name:
    Oxidoreductase HTATIP2
    Protein Accession:
    Q9BUP3
    Secondary Accessions:
    • A8K7S7
    • D3DQY8
    • O15383
    • O60520
    • O95345
    • Q53GC1
    • Q53GG2
    • Q6IBI3

    Protein attributes for HTATIP2 Gene

    Size:
    242 amino acids
    Molecular mass:
    27049 Da
    Quaternary structure:
    • Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through its N-terminus. Binds the activation domain of HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for HTATIP2 Gene

    Alternative splice isoforms for HTATIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTATIP2 Gene

Selected DME Specific Peptides for HTATIP2 Gene

Q9BUP3:
  • YASAFQGHDVGFCCLGTTR
  • QMELLENKAI
  • MQNKSVFILGASGETG
  • VPVVTVVRAMLN
  • LFSKVTLIGRRKLTF
  • EEAYKNVNQEVVDFEKLD
  • FLYLQVKGEVEAKVEELKFDR

Post-translational modifications for HTATIP2 Gene

  • Ubiquitination at isoforms=2, 336 and posLast=137137
  • Modification sites at PhosphoSitePlus

Domains & Families for HTATIP2 Gene

Gene Families for HTATIP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for HTATIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HTATIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUP3

UniProtKB/Swiss-Prot:

HTAI2_HUMAN :
  • Unique C-terminus confers high proteasome-dependent instability to isoform 2.
Domain:
  • Unique C-terminus confers high proteasome-dependent instability to isoform 2.
genes like me logo Genes that share domains with HTATIP2: view

Function for HTATIP2 Gene

Molecular function for HTATIP2 Gene

UniProtKB/Swiss-Prot Function:
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Enzyme Numbers (IUBMB) for HTATIP2 Gene

Phenotypes From GWAS Catalog for HTATIP2 Gene

Gene Ontology (GO) - Molecular Function for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9482853
GO:0005515 protein binding IPI 15282309
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HTATIP2: view
genes like me logo Genes that share phenotypes with HTATIP2: view

Animal Models for HTATIP2 Gene

MGI Knock Outs for HTATIP2:

Animal Model Products

miRNA for HTATIP2 Gene

miRTarBase miRNAs that target HTATIP2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTATIP2 Gene

Localization for HTATIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTATIP2 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTATIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 3
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9482853
GO:0005635 nuclear envelope IEA,IDA 15282309
GO:0005737 cytoplasm IEA,IDA 15282309
GO:0005829 cytosol IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HTATIP2: view

Pathways & Interactions for HTATIP2 Gene

genes like me logo Genes that share pathways with HTATIP2: view

Pathways by source for HTATIP2 Gene

1 GeneTex pathway for HTATIP2 Gene
2 Cell Signaling Technology pathways for HTATIP2 Gene

Gene Ontology (GO) - Biological Process for HTATIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9482853
GO:0006915 apoptotic process IEA --
GO:0007275 multicellular organism development IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with HTATIP2: view

No data available for SIGNOR curated interactions for HTATIP2 Gene

Drugs & Compounds for HTATIP2 Gene

(1) Additional Compounds for HTATIP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with HTATIP2: view

Transcripts for HTATIP2 Gene

Unigene Clusters for HTATIP2 Gene

HIV-1 Tat interactive protein 2, 30kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTATIP2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for HTATIP2 Gene

GeneLoc Exon Structure for
HTATIP2
ECgene alternative splicing isoforms for
HTATIP2

Expression for HTATIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTATIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTATIP2 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for HTATIP2 Gene

This gene is overexpressed in Nasal epithelium (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HTATIP2 Gene



Protein tissue co-expression partners for HTATIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTATIP2 Gene:

HTATIP2

SOURCE GeneReport for Unigene cluster for HTATIP2 Gene:

Hs.90753

mRNA Expression by UniProt/SwissProt for HTATIP2 Gene:

Q9BUP3-HTAI2_HUMAN
Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas.

Evidence on tissue expression from TISSUES for HTATIP2 Gene

  • Pancreas(4.2)
  • Skin(4.2)
  • Lung(3.2)
  • Liver(2.3)
  • Intestine(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with HTATIP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HTATIP2 Gene

Orthologs for HTATIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HTATIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTATIP2 33 34
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia HTATIP2 33 34
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia HTATIP2 33 34
  • 88.98 (n)
mouse
(Mus musculus)
Mammalia Htatip2 33 16 34
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Htatip2 33
  • 85.11 (n)
oppossum
(Monodelphis domestica)
Mammalia HTATIP2 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTATIP2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTATIP2 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTATIP2 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htatip2 33
  • 66.96 (n)
Str.6467 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24303 33
zebrafish
(Danio rerio)
Actinopterygii htatip2 33 34
  • 64.48 (n)
-- 33
worm
(Caenorhabditis elegans)
Secernentea C33F10.14 33 34
  • 52.46 (n)
C33F10.4 35
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP52 34
  • 28 (a)
OneToOne
Species where no ortholog for HTATIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HTATIP2 Gene

ENSEMBL:
Gene Tree for HTATIP2 (if available)
TreeFam:
Gene Tree for HTATIP2 (if available)

Paralogs for HTATIP2 Gene

No data available for Paralogs for HTATIP2 Gene

Variants for HTATIP2 Gene

Sequence variations from dbSNP and Humsavar for HTATIP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs761113892 A hepatocellular carcinoma sample 20,376,622(+) AGTCT(A/G)CAGAG reference, missense
VAR_023713 A hepatocellular carcinoma sample
VAR_023714 A hepatocellular carcinoma sample
VAR_023716 A hepatocellular carcinoma sample
VAR_023717 A hepatocellular carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for HTATIP2 Gene

Variant ID Type Subtype PubMed ID
nsv832083 CNV gain 17160897
nsv7702 CNV insertion 18451855
nsv553678 CNV gain 21841781
nsv469939 CNV gain 18288195
nsv467720 CNV gain 19166990

Variation tolerance for HTATIP2 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTATIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTATIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTATIP2 Gene

Disorders for HTATIP2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for HTATIP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
gnathodiaphyseal dysplasia
  • levin syndrome 2
small cell cancer of the lung, somatic
  • lung small cell carcinoma
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HTATIP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTATIP2
genes like me logo Genes that share disorders with HTATIP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTATIP2 Gene

Publications for HTATIP2 Gene

  1. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. (PMID: 9174052) Shtivelman E (Oncogene 1997) 2 3 4 22 60
  2. TIP30 deficiency increases susceptibility to tumorigenesis. (PMID: 14695192) Ito M … Xiao H (Cancer research 2003) 3 4 22 60
  3. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. (PMID: 11313954) NicAmhlaoibh R … Shtivelman E (Oncogene 2001) 3 4 22 60
  4. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. (PMID: 10611237) Whitman S … Shtivelman E (Molecular and cellular biology 2000) 3 4 22 60
  5. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. (PMID: 9482853) Xiao H … Roeder RG (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60

Products for HTATIP2 Gene

Sources for HTATIP2 Gene

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