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HTATIP2 Gene

protein-coding   GIFtS: 57
GCID: GC11P020385

HIV-1 Tat Interactive Protein 2, 30kDa

(Previous names: HIV-1 Tat interactive protein 2, 30 kDa)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HIV-1 Tat Interactive Protein 2, 30kDa1 2     Member 11
CC32 3 5     Short Chain Dehydrogenase/Reductase Family 44U1
TIP302 3 5     SDR44U12
Tat-Interacting Protein (30kD)1 2     Oxidoreductase HTATIP22
30 KDa HIV-1 TAT-Interacting Protein2 3     Short Chain Dehydrogenase/Reductase Family 44U, Member 12
HIV-1 TAT-Interactive Protein 22 3     EC 1.1.1.-3
HIV-1 Tat Interactive Protein 2, 30 KDa1     EC 1.1.18

External Ids:    HGNC: 166371   Entrez Gene: 105532   Ensembl: ENSG000001098547   OMIM: 6056285   UniProtKB: Q9BUP33   

Export aliases for HTATIP2 gene to outside databases

Previous GC identifers: GC11P021546 GC11P021329 GC11P020424 GC11P020349 GC11P020341 GC11P020068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HTATIP2 Gene:
HTATIP2 (HIV-1 Tat interactive protein 2, 30kDa) is a protein-coding gene. Diseases associated with HTATIP2 include gnathodiaphyseal dysplasia, and hiv-1. GO annotations related to this gene include transcription coactivator activity and oxidoreductase activity.

UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing
with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor
linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with
proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect

Gene Wiki entry for HTATIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTATIP2 gene promoter:
         GCNF   LCR-F1   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HTATIP2 promoter sequence
   Search Chromatin IP Primers for HTATIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTATIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

HTATIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTATIP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P020385:  view genomic region     (about GC identifiers)

Start:
20,385,231 bp from pter      End:
20,405,329 bp from pter
Size:
20,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3 (See protein sequence)
Recommended Name: Oxidoreductase HTATIP2  
Size: 242 amino acids; 27049 Da
Subunit: Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1
and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a
through its N-terminus. Binds the activation domain of HIV-1 Tat
Caution: Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with
protein kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding
NADPH rather than ATP
1 PDB 3D structure from and Proteopedia for HTATIP2:
2BKA (3D)    
Secondary accessions: A8K7S7 D3DQY8 O15383 O60520 O95345 Q53GC1 Q53GG2 Q6IBI3
Alternative splicing: 3 isoforms:  Q9BUP3-1   Q9BUP3-2   Q9BUP3-3   (Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect)

Explore the universe of human proteins at neXtProt for HTATIP2: NX_Q9BUP3

Explore proteomics data for HTATIP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36, Lys137
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HTATIP2 (Q9BUP3) (see all 7)
     QMELLENKAI  VPVVTVVRAMLN  LFSKVTLIGRRKLTF  MQNKSVFILGASGETG 


    See HTATIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001091990.1  NP_001091991.1  NP_001091992.1  NP_001091993.1  NP_006401.3  

    ENSEMBL proteins: 
     ENSP00000436548   ENSP00000397752   ENSP00000387876   ENSP00000392985   ENSP00000394259  
     ENSP00000432338   ENSP00000432107   ENSP00000436729  

    HTATIP2 Human Recombinant Protein Products:

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    OriGene Purified Proteins for HTATIP2
    OriGene Protein Over-expression Lysate for HTATIP2
    OriGene MassSpec for HTATIP2
    OriGene Custom Protein Services for HTATIP2
    GenScript Custom Purified and Recombinant Proteins Services for HTATIP2
    Novus Biologicals HTATIP2 Proteins
    Novus Biologicals HTATIP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HTATIP2
    Cloud-Clone Corp. Proteins for HTATIP2

    HTATIP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for HTATIP2
    LSBio Antibodies in human, mouse, rat for HTATIP2

    HTATIP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HTATIP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTATIP2
    Cloud-Clone Corp. CLIAs for HTATIP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRA: Short chain dehydrogenase/reductase superfamily / Atypical members

    1 InterPro protein domain:
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BUP3

    ProtoNet protein and cluster: Q9BUP3

    UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
    Domain: Unique C-terminus confers high proteasome-dependent instability to isoform 2


    HTATIP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HTAI2_HUMAN, Q9BUP3
    Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing
    with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor
    linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with
    proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect

         Enzyme Numbers (IUBMB): EC 1.1.12 EC 1.1.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS9482853
    GO:0005515protein binding IPI15282309
    GO:0016491oxidoreductase activity IEA--
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----
    GO:0051287NAD binding ----
         
    HTATIP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HTATIP2:
     Decreased viability of wild-ty 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Htatip2):
     cellular  endocrine/exocrine gland  integument  tumorigenesis 

    HTATIP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTATIP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTATIP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTATIP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTATIP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HTATIP2:
    hsa-mir-124-3p (MIRT002630)

    Block miRNA regulation of human, mouse, rat HTATIP2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HTATIP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidHTATIP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTATIP2
    Predesigned siRNA for gene silencing in human, mouse, rat HTATIP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTATIP2

    Clone
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    OriGene clones in human, mouse for HTATIP2 (see all 27)
    OriGene ORF clones in mouse, rat for HTATIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): HTATIP2 (NM_001098521)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTATIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTATIP2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HTATIP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HTATIP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTATIP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HTAI2_HUMAN, Q9BUP3: Cytoplasm. Nucleus envelope
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular3
    endoplasmic reticulum2
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9482853
    GO:0005635nuclear envelope IDA15282309
    GO:0005737cytoplasm IDA--

    HTATIP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTATIP2: 
              Apoptosis 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTATIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for HTATIP2 (Q9BUP33 ENSP000003929854) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    NCOA5Q9HCD53, ENSP000002902314I2D: score=2 STRING: ENSP00000290231
    ETS1ENSP000003764364STRING: ENSP00000376436
    ANAPC5ENSP000002618194STRING: ENSP00000261819
    PMPCBENSP000002492694STRING: ENSP00000249269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9482853
    GO:0006915apoptotic process IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    HTATIP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HTATIP2 (HTAI2)

    1 HMDB Compound for HTATIP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HTATIP2 gene (5 alternative transcripts): 
    NM_001098520.1  NM_001098521.1  NM_001098522.1  NM_001098523.1  NM_006410.4  

    Unigene Cluster for HTATIP2:

    HIV-1 Tat interactive protein 2, 30kDa
    Hs.90753  [show with all ESTs]
    Unigene Representative Sequence: NM_001098522
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530266 ENST00000421577 ENST00000443524 ENST00000419348(uc009yia.1 uc009yib.1 uc001mpx.2)
    ENST00000451739(uc001mpz.2) ENST00000532505 ENST00000532081(uc001mpy.4)
    ENST00000531058 ENST00000533914
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HTATIP2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HTATIP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidHTATIP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HTATIP2
    Predesigned siRNA for gene silencing in human, mouse, rat HTATIP2
    Clone
    Products:
         
    OriGene clones in human, mouse for HTATIP2 (see all 27)
    OriGene ORF clones in mouse, rat for HTATIP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): HTATIP2 (NM_001098521)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTATIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTATIP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HTATIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for HTATIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTATIP2
      QuantiTect SYBR Green Assays in human, mouse, rat HTATIP2
      QuantiFast Probe-based Assays in human, mouse, rat HTATIP2

    Additional mRNA sequence: 

    AF039103.1 AF092095.1 AK130473.1 AK222969.1 AK223010.1 AK292092.1 BC002439.2 BC015358.2 
    CR456821.1 U69161.1 

    16 DOTS entries:

    DT.91637694  DT.117128  DT.95314665  DT.92462264  DT.92462275  DT.95350677  DT.120727233  DT.120727271 
    DT.92462254  DT.100794388  DT.120727269  DT.91849606  DT.120727246  DT.92462265  DT.92462277  DT.100794384 

    Selected AceView cDNA sequences (see all 416):

    AI291488 AI888981 BG196648 BQ436887 BF432973 BG199743 BG182163 CB528339 
    BG183707 BG215452 BG186874 BG183709 AI804445 AW963626 AA398198 BG204876 
    BG217079 BG183188 BM798951 BG186366 BG191559 BG215454 CB142005 CD366835 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HTATIP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                    -     -                 -     -                                       
    SP2:        -     -     -     -                 -     -                                       
    SP3:                                            -     -                                       
    SP4:                                            -     -     -                                 
    SP5:                    -     -                                                               


    ECgene alternative splicing isoforms for HTATIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HTATIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGGATTA
    HTATIP2 Expression
    About this image


    HTATIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    HTATIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTATIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90753

    UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
    Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and
    placenta. Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small
    cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTATIP2: 
              Apoptosis 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HTATIP2
    OriGene qSTAR qPCR primer pairs in human, mouse for HTATIP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTATIP2
    QuantiTect SYBR Green Assays in human, mouse, rat HTATIP2
    QuantiFast Probe-based Assays in human, mouse, rat HTATIP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTATIP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HTATIP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htatip21 , 5 HIV-1 tat interactive protein 2, homolog (human)1, 5 86.61(n)1
    89.34(a)1
      7 (31.44 cM)5
    534151  NM_016865.31  NP_058561.21 
     497591065 
    chicken
    (Gallus gallus)
    Aves HTATIP26
    HIV-1 Tat interactive protein 2, 30kDa
    57(a)
    1 ↔ 1
    8(3682063-3686606) ENSGALG00000002581
    lizard
    (Anolis carolinensis)
    Reptilia HTATIP26
    HIV-1 Tat interactive protein 2, 30kDa
    64(a)
    1 ↔ 1
    GL343326.1(617764-630830)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243032 Xenopus laevis transcribed sequence with weak similarity more 71.62(n)    BJ067392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF329850.12   -- 73.41(n)   64605  AF329850.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C33F10.43
    C33F10.141
    C33F10.141 43(a)3
    52.46(n)1
    44.21(a)1
      II(4795805-4798073)3
    64186221  NM_001026842.31  NP_001022013.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMP526
    Protein of unknown function, localized to the mito...
    28(a)
    1 ↔ 1
    V(159580-160275) YER004W


    ENSEMBL Gene Tree for HTATIP2 (if available)
    TreeFam Gene Tree for HTATIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HTATIP2 (see all 461)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0237144
    A hepatocellular carcinoma sample4--see VAR_0237142 D Y mis40--------
    VAR_0237134
    A hepatocellular carcinoma sample4--see VAR_0237132 R S mis40--------
    VAR_0237174
    A hepatocellular carcinoma sample4--see VAR_0237172 L I mis40--------
    VAR_0237154
    A hepatocellular carcinoma sample4--see VAR_0237152 A T mis40--------
    VAR_0237164
    A hepatocellular carcinoma sample4--see VAR_0237162 G V mis40--------
    rs1808423751,2
    --20383234(+) CAAATG/TTCCAT 1 -- us2k10--------
    rs110255301,2
    C,F,H--20383324(+) ATTCCT/CGATAC 3 -- us2k116Minor allele frequency- C:0.11NS EA NA WA 1548
    rs47579441,2
    C,F--20383330(+) GATACA/GTGAAA 3 -- us2k15Minor allele frequency- G:0.12WA NA EA 362
    rs1838245981,2
    --20383353(+) ATTTAC/TTCATT 3 -- us2k10--------
    rs802625991,2
    F--20383364(+) TGGCAC/TAGTAG 3 -- us2k11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for HTATIP2 (20385231 - 20405329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HTATIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7702CNV Insertion18451855
    nsv467720CNV Gain19166990
    nsv832083CNV Gain17160897
    nsv469939CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HTATIP2
    DNA2.0 Custom Variant and Variant Library Synthesis for HTATIP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605628    OMIM disorders: --

    10 diseases for HTATIP2:    
    About MalaCards
    gnathodiaphyseal dysplasia    hiv-1    lung cancer    multiple sclerosis
    neuroblastoma    hepatocellular carcinoma    prostate cancer    obesity
    prostatitis    breast cancer


    HTATIP2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HTATIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 60 1 19349353 (1)
    metastasis 45.4 22 19349353 (5), 18537194 (4), 18528861 (3), 10892349 (2) (see all 7)
    tumors 21.6 19 18537194 (5), 11313954 (5), 10611237 (2), 19349353 (2) (see all 7)


    Export disorders for HTATIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HTATIP2 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with HTATIP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. (PubMed id 9174052)1, 2, 3, 9 Shtivelman E. (Oncogene 1997)
    2. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. (PubMed id 9482853)1, 2, 3 Xiao H.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. (PubMed id 10611237)1, 2, 9 Whitman S.... Shtivelman E. (Mol. Cell. Biol. 2000)
    4. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. (PubMed id 11313954)1, 2, 9 NicAmhlaoibh R. and Shtivelman E. (Oncogene 2001)
    5. TIP30 deficiency increases susceptibility to tumorigenesis. (PubMed id 14695192)1, 2, 9 Ito M.... Xiao H. (Cancer Res. 2003)
    6. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    7. Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. (PubMed id 15728189)1, 2 El Omari K.... Stammers D.K. (J. Biol. Chem. 2005)
    8. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PubMed id 15073177)1, 2 Jiang C.... Xiao H. (J. Biol. Chem. 2004)
    9. Inhibition of nuclear import by the proapoptotic protein CC3. (PubMed id 15282309)1, 2 King F.W. and Shtivelman E. (Mol. Cell. Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10553 HGNC: 16637 AceView: HTATIP2 Ensembl:ENSG00000109854 euGenes: HUgn10553
    ECgene: HTATIP2 H-InvDB: HTATIP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HTATIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HTATIP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HTATIP2 gene:
    Search GeneIP for patents involving HTATIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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