Aliases for HTATIP2 Gene
External Ids for HTATIP2 Gene
Previous GeneCards Identifiers for HTATIP2 Gene
GeneCards Summary for HTATIP2 Gene
HTATIP2 (HIV-1 Tat Interactive Protein 2) is a Protein Coding gene. Diseases associated with HTATIP2 include Hiv-1 and Gnathodiaphyseal Dysplasia. Among its related pathways are Apoptosis and Autophagy and Cytoskeletal Signaling. GO annotations related to this gene include oxidoreductase activity and NAD binding.
UniProtKB/Swiss-Prot for HTATIP2 Gene
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.