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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTATIP2 Gene

protein-coding   GIFtS: 55
GCID: GC11P020341

HIV-1 Tat interactive protein 2, 30kDa

(Previous names: HIV-1 Tat interactive protein 2, 30 kDa )
 Explore 12 diseases affiliated with
HTATIP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HTATIP2    

Aliases
for HTATIP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HIV-1 Tat Interactive Protein 2, 30kDa1 2     HIV-1 Tat Interactive Protein 2, 30 KDa1
CC31 2 3 5     Oxidoreductase HTATIP22
TIP301 2 3 5     Short Chain Dehydrogenase/Reductase Family 44U, Member 12
SDR44U11 2     Tat-Interacting Protein (30kD)2
30 KDa HIV-1 TAT-Interacting Protein2 3     EC 1.1.1.-3
HIV-1 TAT-Interactive Protein 22 3     EC 1.1.18
FLJ269631     

External Ids:    HGNC: 166371   Entrez Gene: 105532   Ensembl: ENSG000001098547   OMIM: 6056285   UniProtKB: Q9BUP33   

Export aliases for HTATIP2 gene to outside databases

Previous GC identifers: GC11P021546 GC11P021329 GC11P020424 GC11P020349 GC11P020068


Summaries
for HTATIP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with
nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to
transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as
antiangiogenic properties. Isoform 2 has an antiapoptotic effect

Gene Wiki entry for HTATIP2


Genomic Views
for HTATIP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTATIP2 gene promoter:
         GCNF   LCR-F1   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HTATIP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HTATIP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTATIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

HTATIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTATIP2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P020341:  view genomic region     (about GC identifiers)

Start:
 20,385,231 bp from pter      End:
 20,405,329 bp from pter
Size:
 20,099 bases      Orientation:
 plus strand

Proteins
for HTATIP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3 (See protein sequence)
Recommended Name: Oxidoreductase HTATIP2  
Size: 242 amino acids; 27049 Da
Subunit: Monomer. Binds nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and
LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA. Isoform 2 binds the proteasome subunit PSMD4/s5a through
its N-terminus. Binds the activation domain of HIV-1 Tat
Subcellular location: Cytoplasm. Nucleus envelope
Caution: Was originally (PubMed:9482853 and PubMed:10698937) thought to be a transcriptional coregulator with protein
kinase activity. However, crystal structure reveals a short chain dehydrogenase/reductase fold binding NADPH rather
than ATP
1 PDB 3D structure from and Proteopedia for HTATIP2:
2BKA (3D)    
Secondary accessions: A8K7S7 D3DQY8 O15383 O60520 O95345 Q53GC1 Q53GG2 Q6IBI3
Alternative splicing: 3 isoforms:  Q9BUP3-1   Q9BUP3-2   Q9BUP3-3   (Mutagenesis of Leu-154 and Leu-157 or Cys-158, Cys-160 and Cys-161 abolishes antiapoptotic effect)

Explore the universe of human proteins at neXtProt for HTATIP2: NX_Q9BUP3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUP3

    • 4/7 DME Specific Peptides for HTATIP2 (Q9BUP3) (see all 7)
     QMELLENKAI  VPVVTVVRAMLN  LFSKVTLIGRRKLTF  MQNKSVFILGASGETG 

    HTATIP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001091990.1  NP_001091991.1  NP_001091992.1  NP_001091993.1  NP_006401.3  

    ENSEMBL proteins: 
     ENSP00000436548   ENSP00000397752   ENSP00000387876   ENSP00000392985   ENSP00000394259  
     ENSP00000432338   ENSP00000432107   ENSP00000436729  

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    OriGene Purified Proteins (see all 2): HTATIP2
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    Novus Biologicals HTATIP2 Proteins
    Novus Biologicals HTATIP2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HTATIP2
    Uscn Proteins for HTATIP2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9482853
    GO:0005635nuclear envelope IDA15282309
    GO:0005737cytoplasm IDA--


    HTATIP2 for ontologies           About GeneDecksing



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    Uscn Antibodies for HTATIP2
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    Uscn ELISAs and CLIAs for HTATIP2

    Protein Domains /
    Families
    for HTATIP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HTATIP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9BUP3

    ProtoNet protein and cluster: Q9BUP3

    UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
    Domain: Unique C-terminus confers high proteasome-dependent instability to isoform 2


    Function
    for HTATIP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
    Function: Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with
    nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to
    transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as
    antiangiogenic properties. Isoform 2 has an antiapoptotic effect

    Enzyme Numbers (IUBMB): EC 1.1.12 EC 1.1.1.-1

    miRNA
    Products:            		miRTarBase miRNAs that target HTATIP2:
    hsa-mir-124 (MIRT002630)

    OriGene 3'-UTR Clone (see all 5): HTATIP2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTATIP2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTATIP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: HTATIP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTATIP2 (see all 6)
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HTATIP2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTATIP2 (see all 11)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): HTATIP2 (NM_001098521)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTATIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTATIP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for HTATIP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTATIP2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003713transcription coactivator activity TAS9482853
    GO:0005515protein binding IPI15282309
    GO:0016491oxidoreductase activity IEA--


    HTATIP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HTATIP2:
     Decreased viability of wild-ty 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Htatip2):
     cellular  endocrine/exocrine gland  integument  tumorigenesis 

    HTATIP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HTATIP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HTATIP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for HTATIP2 (Q9BUP33 ENSP000003929854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    NCOA5Q9HCD53, ENSP000002902314I2D: score=2 STRING: ENSP00000290231
    ETS1ENSP000003764364STRING: ENSP00000376436
    UBCENSP000003448184STRING: ENSP00000344818
    --Q6N0873I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9482853
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis TAS9174052
    GO:0019048virus-host interaction IEA--


    HTATIP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HTATIP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HTATIP2

    1 HMDB Compound for HTATIP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Search CenterWatch for drugs/clinical trials and news about HTATIP2 / HTAI2 

    Transcripts
    for HTATIP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HTATIP2 gene (5 alternative transcripts): 
    NM_001098520.1  NM_001098521.1  NM_001098522.1  NM_001098523.1  NM_006410.4  

    Unigene Cluster for HTATIP2:

    HIV-1 Tat interactive protein 2, 30kDa
    Hs.90753  [show with all ESTs]
    Unigene Representative Sequence: NM_001098522
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530266 ENST00000421577 ENST00000443524 ENST00000419348(uc009yia.1 uc009yib.1 uc001mpx.2)
    ENST00000451739(uc001mpz.2) ENST00000532505 ENST00000532081(uc001mpy.4)
    ENST00000531058 ENST00000533914

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): HTATIP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTATIP2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTATIP2:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: HTATIP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTATIP2 (see all 6)
    Browse OriGene siRNA
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    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTATIP2 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): HTATIP2 (NM_001098521)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTATIP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTATIP2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTATIP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTATIP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTATIP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTATIP2

    Additional cDNA sequence: 

    AF039103.1 AF092095.1 AK130473.1 AK222969.1 AK223010.1 AK292092.1 BC002439.2 BC015358.2 
    CR456821.1 U69161.1 

    16 DOTS entries:

    DT.91637694  DT.117128  DT.95314665  DT.92462264  DT.92462275  DT.95350677  DT.120727233  DT.120727271 
    DT.92462254  DT.100794388  DT.120727269  DT.91849606  DT.120727246  DT.92462265  DT.92462277  DT.100794384 

    24/416 AceView cDNA sequences (see all 416):

    BQ956474 AA398198 BG193655 BQ778607 BG196648 AI888981 CD366934 BF432973 
    BG183707 AI804445 BG186366 BG186874 BG194174 AA515872 AI802651 BE504227 
    BG217079 BG195677 BG227992 BG212246 BG191562 BG194655 CB142005 BG191559 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HTATIP2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                    -     -                 -     -                                       
    SP2:        -     -     -     -                 -     -                                       
    SP3:                                            -     -                                       
    SP4:                                            -     -     -                                 
    SP5:                    -     -                                                               


    ECgene alternative splicing isoforms for HTATIP2

    Expression
    for HTATIP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTATIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAGGATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HTATIP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cardiomyocyte-like cells (Spontaneous differen...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HTATIP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTATIP2

    SOURCE GeneReport for Unigene cluster: Hs.90753

    UniProtKB/Swiss-Prot: HTAI2_HUMAN, Q9BUP3
    Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta.
    Moderate levels in heart and kidney. Low levels in brain. Not expressed or low levels in variant small cell lung
    carcinomas, 33% of hepatocellular carcinomas and neuroblastomas

        SABiosciences Expression via Pathway-Focused PCR Arrays including HTATIP2: 
              Apoptosis 384HT in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTATIP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTATIP2

    Orthologs
    for HTATIP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HTATIP2 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Htatip21 , 5 HIV-1 tat interactive protein 2, homolog (human)1, 5 84.7(n)1
    85.45(a)1    		   7 (31.44 cM)5
    534151  NM_016865.31  NP_058561.21 
     497591065 
    chicken
    (Gallus gallus)    		 Aves HTATIP26
    		 Uncharacterized protein
    		 55(a)
    		 1 ↔ 1
    		 8(3720860-3723312)
    lizard
    (Anolis carolinensis)    		 Reptilia HTATIP26
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343326.1(620882-628261)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.243032 Xenopus laevis transcribed sequence with weak similarity more 71.62(n)    BJ067392.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF329850.12   -- 73.41(n)   64605  AF329850.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C33F10.43
    C33F10.141    		 Protein C33F10.141 43(a)3
    52.46(n)1
    44.21(a)1    		   II(4795805-4798073)3
    64186221  NM_001026842.21  NP_001022013.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes FMP521 Fmp52p 43.87(n)
    37.42(a)    		   856721   NP_010919.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria yraR6
    		 predicted nucleoside-diphosphate-sugar epimerase
    		 30(a)
    		 1 ↔ 1
    		 Chromosome(3296233-3296868) b3152


    ENSEMBL Gene Tree for HTATIP2 (if available)
    TreeFam Gene Tree for HTATIP2 (if available) 

    Paralogs
    for HTATIP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for HTATIP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/396 NCBI SNPs in HTATIP2 are shown (see all 396)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1808423751,2
    		--20383234(+) CAAATG/TTCCAT 1 -- us2k10--------
    rs110255301,2
    		C,F,H,--20383324(+) ATTCCT/CGATAC 3 -- us2k116Minor allele frequency- C:0.11NS EA NA WA 1548
    rs47579441,2
    		C,F,--20383330(+) GATACA/GTGAAA 3 -- us2k15Minor allele frequency- G:0.12WA NA EA 362
    rs1838245981,2
    		--20383353(+) ATTTAC/TTCATT 3 -- us2k10--------
    rs802625991,2
    		F,--20383364(+) TGGCAC/TAGTAG 3 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1899961711,2
    		--20383382(+) TCTGGA/GGCCTG 3 -- us2k10--------
    rs1404684181,2
    		C,--20383487(+) ATTAT-/ATAA  
                ATAGT     		4 -- us2k10--------
    rs1486608751,2
    		--20383579(+) GGCTCA/GTGAAG 4 -- us2k10--------
    rs781013981,2
    		C--20383593(+) TTAGGC/GCCCAT 4 -- us2k10--------
    rs110255311,2
    		C,F,A,--20383636(+) AAATAC/G/TTAAAA 4 -- us2k16NA WA EA 364

    HapMap Linkage Disequilibrium report for HTATIP2 (20385231 - 20405329 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HTATIP2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTATIP2
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    Disorders / Diseases
    for HTATIP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HTATIP2 for disorders           About GeneDecksing

    OMIM gene information: 605628    OMIM disorders: --

    12 diseases for HTATIP2:    About MalaCards
    gnathodiaphyseal dysplasia    multiple sclerosis    lung cancer    hepatocellular carcinoma
    gastric cancer    lung carcinoma    breast carcinoma    carcinoma
    prostate cancer    breast cancer    neuroblastoma    prostatitis

    3 Novoseek disease relationships for HTATIP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    small cell lung cancer 60 1 19349353 (1)
    metastasis 45.4 22 19349353 (5), 18537194 (4), 18528861 (3), 10892349 (2) (see all 7)
    tumors 21.6 19 18537194 (5), 11313954 (5), 10611237 (2), 19349353 (2) (see all 7)


    Export disorders for HTATIP2 gene to outside databases

    Publications
    for HTATIP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTATIP2 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with HTATIP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. (PubMed id 9174052)1, 2, 3, 9 Shtivelman E. (1997)
    2. A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription. (PubMed id 9482853)1, 2, 3 Xiao H.... Roeder R.G. (1998)
    3. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. (PubMed id 10611237)1, 2, 9 Whitman S.... Shtivelman E. (2000)
    4. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. (PubMed id 11313954)1, 2, 9 NicAmhlaoibh R. and Shtivelman E. (2001)
    5. TIP30 deficiency increases susceptibility to tumorigenesis. (PubMed id 14695192)1, 2, 9 Ito M.... Xiao H. (2003)
    6. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    7. Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor. (PubMed id 15728189)1, 2 El Omari K.... Stammers D.K. (2005)
    8. TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. (PubMed id 15073177)1, 2 Jiang C.... Xiao H. (2004)
    9. Inhibition of nuclear import by the proapoptotic protein CC3. (PubMed id 15282309)1, 2 King F.W. and Shtivelman E. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for HTATIP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HTATIP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10553 HGNC: 16637 AceView: HTATIP2 Ensembl:ENSG00000109854 euGenes: HUgn10553
    ECgene: HTATIP2 H-InvDB: HTATIP2

    Other Databases showing HTATIP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HTATIP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTATIP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HTATIP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HTATIP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HTATIP2 gene:
    Search GeneIP for patents involving HTATIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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