Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPH1 Gene

Aliases for HSPH1 Gene

  • Heat Shock 105kDa/110kDa Protein 1 2 3
  • Antigen NY-CO-25 3 4
  • HSP105 3 4
  • Heat Shock 110 KDa Protein 4
  • Heat Shock 105kD Alpha 3
  • Heat Shock 105kD Beta 3
  • NY-CO-25 3
  • KIAA0201 4
  • HSP105A 3
  • HSP105B 3
  • HSP110 4

External Ids for HSPH1 Gene

Previous GeneCards Identifiers for HSPH1 Gene

  • GC13M025697
  • GC13M030645
  • GC13M029508
  • GC13M030608
  • GC13M031710
  • GC13M012522

Summaries for HSPH1 Gene

GeneCards Summary for HSPH1 Gene

HSPH1 (Heat Shock 105kDa/110kDa Protein 1) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Vesicle-mediated transport. GO annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is HSPA4L.

UniProtKB/Swiss-Prot for HSPH1 Gene

  • Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Gene Wiki entry for HSPH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPH1 Gene

Genomics for HSPH1 Gene

Regulatory Elements for HSPH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPH1 Gene

Chromosome:
13
Start:
31,134,974 bp from pter
End:
31,163,109 bp from pter
Size:
28,136 bases
Orientation:
Minus strand

Genomic View for HSPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPH1 Gene

Proteins for HSPH1 Gene

  • Protein details for HSPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92598-HS105_HUMAN
    Recommended name:
    Heat shock protein 105 kDa
    Protein Accession:
    Q92598
    Secondary Accessions:
    • B4DYH1
    • O95739
    • Q5TBM6
    • Q5TBM7
    • Q5TBM8
    • Q9UPC4

    Protein attributes for HSPH1 Gene

    Size:
    858 amino acids
    Molecular mass:
    96865 Da
    Quaternary structure:
    • Interacts with HSPA8/HSC70.
    SequenceCaution:
    • Sequence=AAC18044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13192.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPH1 Gene

Proteomics data for HSPH1 Gene at MOPED

Post-translational modifications for HSPH1 Gene

  • Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
  • Ubiquitination at Lys 44, Lys 53, Lys 68, Lys 95, Lys 221, Lys 234, Lys 430, Lys 458, and Lys 790
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HSPH1 Gene

Domains & Families for HSPH1 Gene

Gene Families for HSPH1 Gene

Protein Domains for HSPH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92598

UniProtKB/Swiss-Prot:

HS105_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPH1: view

Function for HSPH1 Gene

Molecular function for HSPH1 Gene

UniProtKB/Swiss-Prot Function:
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Gene Ontology (GO) - Molecular Function for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17024176
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPH1: view

Animal Model Products

miRNA for HSPH1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPH1 Gene

Localization for HSPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPH1 Gene COMPARTMENTS Subcellular localization image for HSPH1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 12952910
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 9931472
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSPH1: view

Pathways & Interactions for HSPH1 Gene

genes like me logo Genes that share pathways with HSPH1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006986 response to unfolded protein TAS 9931472
GO:0034605 cellular response to heat TAS --
GO:0045345 positive regulation of MHC class I biosynthetic process TAS 12952910
GO:0051135 positive regulation of NK T cell activation TAS 12952910
genes like me logo Genes that share ontologies with HSPH1: view

No data available for SIGNOR curated interactions for HSPH1 Gene

Drugs & Compounds for HSPH1 Gene

(1) Drugs for HSPH1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Pharma Activator 0
genes like me logo Genes that share compounds with HSPH1: view

Transcripts for HSPH1 Gene

Unigene Clusters for HSPH1 Gene

Heat shock 105kDa/110kDa protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPH1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1:
SP2: -
SP3: -
SP4:
SP5: -
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:

Relevant External Links for HSPH1 Gene

GeneLoc Exon Structure for
HSPH1
ECgene alternative splicing isoforms for
HSPH1

Expression for HSPH1 Gene

mRNA expression in normal human tissues for HSPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPH1 Gene

This gene is overexpressed in Frontal cortex (8.7) and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPH1 Gene



SOURCE GeneReport for Unigene cluster for HSPH1 Gene Hs.743267

mRNA Expression by UniProt/SwissProt for HSPH1 Gene

Q92598-HS105_HUMAN
Tissue specificity: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
genes like me logo Genes that share expression patterns with HSPH1: view

Protein tissue co-expression partners for HSPH1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HSPH1 Gene

Orthologs for HSPH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPH1 35
  • 91.3 (n)
  • 94.41 (a)
HSPH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPH1 35
  • 93.27 (n)
  • 95.5 (a)
HSPH1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsph1 35
  • 86.43 (n)
  • 93.58 (a)
Hsph1 16
Hsph1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPH1 35
  • 99.84 (n)
  • 100 (a)
HSPH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsph1 35
  • 85.76 (n)
  • 92.53 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPH1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPH1 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPH1 35
  • 78.12 (n)
  • 82.3 (a)
HSPH1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPH1 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7571 35
zebrafish
(Danio rerio)
Actinopterygii hsph1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hsp-110 36
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE2 35
  • 50.78 (n)
  • 41.83 (a)
SSE1 36
  • 40 (a)
ManyToMany
SSE2 36
  • 39 (a)
ManyToMany
SSE2 38
barley
(Hordeum vulgare)
Liliopsida Hv.3246 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 36
  • 44 (a)
OneToMany
Species with no ortholog for HSPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPH1 Gene

ENSEMBL:
Gene Tree for HSPH1 (if available)
TreeFam:
Gene Tree for HSPH1 (if available)

Paralogs for HSPH1 Gene

Paralogs for HSPH1 Gene

genes like me logo Genes that share paralogs with HSPH1: view

Variants for HSPH1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSPH1 Gene

Variant ID Type Subtype PubMed ID
esv2751142 CNV Gain 17911159
nsv528568 CNV Gain 19592680

Variation tolerance for HSPH1 Gene

Residual Variation Intolerance Score: 39.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPH1 Gene

HapMap Linkage Disequilibrium report
HSPH1
Human Gene Mutation Database (HGMD)
HSPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HSPH1 Gene

Disorders for HSPH1 Gene

Relevant External Links for HSPH1

Genetic Association Database (GAD)
HSPH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPH1
genes like me logo Genes that share disorders with HSPH1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPH1 Gene

Publications for HSPH1 Gene

  1. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. (PMID: 9931472) Ishihara K. … Hatayama T. (Biochim. Biophys. Acta 1999) 2 23 67
  2. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J. … Kampinga H.H. (Mol. Cell 2010) 23 67
  3. Overexpression of Apg-2 increases cell proliferation and protects from oxidative damage in BaF3-BCR/ABL cells. (PMID: 20198334) Li C. … Feng W. (Int. J. Oncol. 2010) 23 67
  4. Induction of expression and co-localization of heat shock polypeptides with the polyalanine expansion mutant of poly(A)-binding protein N1 after chemical stress. (PMID: 18343218) Wang Q. … Bag J. (Biochem. Biophys. Res. Commun. 2008) 23 67
  5. Differential expression of heat shock protein 105 in melanoma and melanocytic naevi. (PMID: 18477890) Muchemwa F.C. … Ihn H. (Melanoma Res. 2008) 23 67

Products for HSPH1 Gene

Sources for HSPH1 Gene

Back to Top

Content