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Aliases for HSPH1 Gene

Aliases for HSPH1 Gene

  • Heat Shock 105kDa/110kDa Protein 1 2 3
  • HSP105 3 4 6
  • Antigen NY-CO-25 3 4
  • KIAA0201 4 6
  • Heat Shock Protein 105 KDa 3
  • Heat Shock 110 KDa Protein 4
  • Heat Shock 105kD Alpha 3
  • Heat Shock 105kD Beta 3
  • NY-CO-25 3
  • HSP105A 3
  • HSP105B 3
  • HSP110 4

External Ids for HSPH1 Gene

Summaries for HSPH1 Gene

GeneCards Summary for HSPH1 Gene

HSPH1 (Heat Shock 105kDa/110kDa Protein 1) is a Protein Coding gene. Diseases associated with HSPH1 include hepatitis d. Among its related pathways are Protein processing in endoplasmic reticulum and Binding and Uptake of Ligands by Scavenger Receptors. GO annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is HSPA4L.

UniProtKB/Swiss-Prot for HSPH1 Gene

  • Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Gene Wiki entry for HSPH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPH1 Gene

Genomics for HSPH1 Gene

Genomic Location for HSPH1 Gene

31,134,974 bp from pter
31,163,109 bp from pter
28,136 bases
Minus strand

Genomic View for HSPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPH1 Gene

Regulatory Elements for HSPH1 Gene

Proteins for HSPH1 Gene

  • Protein details for HSPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein 105 kDa
    Protein Accession:
    Secondary Accessions:
    • B4DYH1
    • O95739
    • Q5TBM6
    • Q5TBM7
    • Q5TBM8
    • Q9UPC4

    Protein attributes for HSPH1 Gene

    858 amino acids
    Molecular mass:
    96865 Da
    Quaternary structure:
    • Interacts with HSPA8/HSC70.
    • Sequence=AAC18044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13192.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPH1 Gene


neXtProt entry for HSPH1 Gene

Proteomics data for HSPH1 Gene at MOPED

Post-translational modifications for HSPH1 Gene

  • Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys53, Lys68, Lys95, Lys221, Lys234, Lys388, Lys430, Lys458, and Lys790

Other Protein References for HSPH1 Gene

No data available for DME Specific Peptides for HSPH1 Gene

Domains for HSPH1 Gene

Gene Families for HSPH1 Gene

  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPH1 Gene


  • Belongs to the heat shock protein 70 family.:
    • Q92598
genes like me logo Genes that share domains with HSPH1: view

Function for HSPH1 Gene

Molecular function for HSPH1 Gene

UniProtKB/Swiss-Prot Function: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Gene Ontology (GO) - Molecular Function for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17024176
GO:0005524 ATP binding IEA --
GO:0043014 alpha-tubulin binding IEA --
genes like me logo Genes that share ontologies with HSPH1: view

miRNA for HSPH1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPH1 Gene

Localization for HSPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPH1 Gene


Subcellular locations from

Jensen Localization Image for HSPH1 Gene COMPARTMENTS Subcellular localization image for HSPH1 gene
Compartment Confidence
cytosol 4
extracellular 4
nucleus 4
cytoskeleton 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 12952910
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HSPH1: view

Pathways for HSPH1 Gene

genes like me logo Genes that share pathways with HSPH1: view

Pathways by source for HSPH1 Gene

Gene Ontology (GO) - Biological Process for HSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006986 response to unfolded protein TAS 9931472
GO:0034605 cellular response to heat TAS --
GO:0045345 positive regulation of MHC class I biosynthetic process TAS 12952910
genes like me logo Genes that share ontologies with HSPH1: view

Compounds for HSPH1 Gene

(1) Novoseek inferred chemical compound relationships for HSPH1 Gene

Compound -log(P) Hits PubMed IDs
atp 35.7 3
genes like me logo Genes that share compounds with HSPH1: view

Transcripts for HSPH1 Gene

Unigene Clusters for HSPH1 Gene

Heat shock 105kDa/110kDa protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPH1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP2: -
SP3: -
SP5: -
SP6: - - - - -
SP7: -

ExUns: 18 ^ 19a · 19b · 19c ^ 20a · 20b ^ 21
SP1: -
SP11: - -

Relevant External Links for HSPH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPH1 Gene

mRNA expression in normal human tissues for HSPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPH1 Gene

SOURCE GeneReport for Unigene cluster for HSPH1 Gene Hs.743267

mRNA Expression by UniProt/SwissProt for HSPH1 Gene

Tissue specificity: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
genes like me logo Genes that share expressions with HSPH1: view

Orthologs for HSPH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPH1 36
  • 99.84 (n)
  • 100 (a)
HSPH1 37
  • 100 (a)
(Bos Taurus)
Mammalia HSPH1 36
  • 91.3 (n)
  • 94.41 (a)
HSPH1 37
  • 94 (a)
(Canis familiaris)
Mammalia HSPH1 36
  • 93.27 (n)
  • 95.5 (a)
HSPH1 37
  • 92 (a)
(Mus musculus)
Mammalia Hsph1 36
  • 86.43 (n)
  • 93.58 (a)
Hsph1 16
Hsph1 37
  • 93 (a)
(Monodelphis domestica)
Mammalia HSPH1 37
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia HSPH1 37
  • 41 (a)
(Rattus norvegicus)
Mammalia Hsph1 36
  • 85.76 (n)
  • 92.53 (a)
(Gallus gallus)
Aves HSPH1 36
  • 78.12 (n)
  • 82.3 (a)
HSPH1 37
  • 70 (a)
(Anolis carolinensis)
Reptilia HSPH1 37
  • 67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7571 36
(Danio rerio)
Actinopterygii hsph1 37
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea hsp-110 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 37
  • 40 (a)
SSE2 36
  • 50.78 (n)
  • 41.83 (a)
SSE2 37
  • 39 (a)
SSE2 39
(Hordeum vulgare)
Liliopsida Hv.3246 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 37
  • 44 (a)
Species with no ortholog for HSPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPH1 Gene

Gene Tree for HSPH1 (if available)
Gene Tree for HSPH1 (if available)

Paralogs for HSPH1 Gene

Paralogs for HSPH1 Gene

genes like me logo Genes that share paralogs with HSPH1: view

Variants for HSPH1 Gene

Sequence variations from dbSNP and Humsavar for HSPH1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs2580 -- 31,137,181(+) TTTTT(C/T)CTTTT utr-variant-3-prime
rs723918 -- 31,142,310(-) TGGAA(C/T)GTGGG intron-variant
rs972370 -- 31,162,866(-) AACAA(A/G)AAGCA upstream-variant-2KB, utr-variant-5-prime
rs974156 -- 31,161,538(-) TACAT(A/C)GCGGT synonymous-codon, reference, intron-variant
rs1047086 -- 31,155,592(-) TTCAA(C/T)GACCC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for HSPH1 Gene

Variant ID Type Subtype PubMed ID
esv2751142 CNV Gain 17911159
nsv528568 CNV Gain 19592680

Relevant External Links for HSPH1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for HSPH1 Gene

(1) MalaCards Diseases for HSPH1 Gene

Search for HSPH1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for HSPH1 Gene

Disease -log(P) Hits PubMed IDs
shock 65.5 14
colorectal cancer 0.782 4
tumors 0 7
cancer 0 7

Relevant External Links for HSPH1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with HSPH1: view

No data available for UniProtKB/Swiss-Prot for HSPH1 Gene

Publications for HSPH1 Gene

  1. Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105. (PMID: 9931472) Ishihara K. … Hatayama T. (Biochim. Biophys. Acta 1999) 2 3 4 23
  2. The distribution and localization of hsp110 in brain. (PMID: 10865058) Hylander B.L. … Subjeck J.R. (Brain Res. 2000) 3 4 23
  3. DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells. (PMID: 16232202) Miyazaki M. … Nishimura Y. (Cancer Sci. 2005) 3 4 23
  4. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  5. Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression. (PMID: 12952910) Nicchitta C.V. (J. Clin. Invest. 2003) 3 23

Products for HSPH1 Gene

  • Addgene plasmids for HSPH1

Sources for HSPH1 Gene

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