Aliases for HSPH1 Gene
External Ids for HSPH1 Gene
Previous GeneCards Identifiers for HSPH1 Gene
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
GeneCards Summary for HSPH1 Gene
HSPH1 (Heat Shock Protein Family H (Hsp110) Member 1) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Protein processing in endoplasmic reticulum. GO annotations related to this gene include alpha-tubulin binding. An important paralog of this gene is HSPA4.
UniProtKB/Swiss-Prot for HSPH1 Gene
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).