Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPG2 Gene

protein-coding GIFtS: 69
GCID: GC01M022148

heparan sulfate proteoglycan 2

(Previous name: Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia)...)
(Previous symbol: SJS1)

Explore 169 diseases affiliated with
HSPG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heparan Sulfate Proteoglycan 2¹ ²		Perlecan³
SJS1¹ ² ⁵		Schwartz-Jampel Syndrome 1 (Chondrodystrophic Myotonia)¹
PLC² ³ ⁵		Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein²
PRCAN¹ ²		Endorepellin (Domain V Region)²
HSPG² ³		Perlecan Proteoglycan²
SJA² ⁵		Perlecan³
SJS² ⁵

External Ids:	HGNC: 5273¹	Entrez Gene: 3339²	Ensembl: ENSG00000142798⁷	OMIM: 142461⁵	UniProtKB: P98160³

Export aliases for HSPG2 gene to outside databases

Previous GC identifers: GC01M021719 GC01M021183 GC01M021294 GC01M021619 GC01M021620 GC01M021894 GC01M022021 GC01M020392

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPG2:

This gene encodes the perlecan protein, which consists of a core protein to which three long chains of

glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain

proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has

been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and

Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the

vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor

of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote

growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component

of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with

glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome

type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160

Function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible

for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and

charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical

for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage

development

Function: Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration,

collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks

endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with

its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in

phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine

phosphatase, PTPN6

Function: The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity

Gene Wiki entry for HSPG2 (Perlecan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPG2 gene promoter:
Egr-3 Elk-1 AML1a Tal-1 POU3F1 E47 MZF-1 N-Myc ARP-1 Msx-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPG2 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p34 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.1-p35

HSPG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPG2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M022148: view genomic region (about GC identifiers)

Start:	22,148,737 bp from pter	End:	22,263,790 bp from pter
Size:	115,054 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160 (See protein sequence)

Recommended Name: Basement membrane-specific heparan sulfate proteoglycan core protein precursor

Size: 4391 amino acids; 468830 Da

Subunit: Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other

basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1.

Interacts (via C-terminus) with ECM1 (via C-terminus)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

Miscellaneous: The LG3 peptide has been found in the urine of patients with end-stage renal disease and in the amniotic

fluid of pregnant women with premature rupture of fetal membranes

2 PDB 3D structures from and Proteopedia for HSPG2:

3SH4 (3D)

3SH5 (3D)

Secondary accessions: Q16287 Q5SZI3 Q9H3V5

Explore the universe of human proteins at neXtProt for HSPG2: NX_P98160

Post-translational modifications:

Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed

to produce the LG3 peptide¹

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Perlecan contains three heparan sulfate

chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P98160

HSPG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005520.4

ENSEMBL proteins:

ENSP00000363827 ENSP00000392022 ENSP00000363808 ENSP00000396310 ENSP00000397573

ENSP00000436271 ENSP00000405412 ENSP00000363805 ENSP00000395884 ENSP00000416385

Reactome Protein details: P98160
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for HSPG2 (Endorepellin/Perlecan)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HSPG2 OriGene Custom Protein Services for HSPG2
	GenScript Custom Purified and Recombinant Proteins Services for HSPG2
	Novus Biologicals HSPG2 Protein Novus Biologicals HSPG2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HSPG2

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	--	--
GO:0005604	basement membrane	--	--
GO:0005605	basal lamina	IEA	--
GO:0005615	extracellular space	IDA	--

HSPG2 for ontologies About GeneDecksing

HSPG2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPG2
	R&D Systems Antibodies for HSPG2 (Endorepellin/Perlecan)
	Browse OriGene Antibodies OriGene Custom Antibody Services for HSPG2
	GenScript Custom Superior Antibodies Services for HSPG2
	Novus Biologicals HSPG2 Antibodies
	Search for Antibodies for HSPG2 at Abcam
	Uscn Antibodies for HSPG2
	ThermoFisher Antibodies for HSPG2

Assay Products for HSPG2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSPG2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HSPG2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPG2 for domains About GeneDecksing

5/15 InterPro domains/families (see all 15):

IPR003598 Ig_sub2

IPR000034 Laminin_B_type_IV

IPR023415 LDLR_class-A_CS

IPR000742 EG-like_dom

IPR013320 ConA-like_subgrp

Graphical View of Domain Structure for InterPro Entry P98160

ProtoNet protein and cluster: P98160

5/12 Blocks protein families (see all 12):

IPB000082 SEA domain

IPB001438 Type II EGF-like signature

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160

Similarity: Contains 4 EGF-like domains

Similarity: Contains 22 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 11 laminin EGF-like domains

Similarity: Contains 3 laminin G-like domains

Similarity: Contains 3 laminin IV type A domains

Similarity: Contains 4 LDL-receptor class A domains

Similarity: Contains 1 SEA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160

Function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible

for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and

charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical

for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage

development

Function: Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration,

collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks

endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with

its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in

phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine

phosphatase, PTPN6

Function: The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity

Genatlas biochemistry entry for HSPG2:

heparan sulfate proteoglycan 2 (64kDa),basement membrane,syndecan family,linking the cytoskeleton to interstitial

matrix

miRNA Products:		OriGene 3'-UTR Clone: HSPG2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPG2
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPG2 (see all 29):
		hsa-miR-1197 hsa-miR-520d-5p hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-503 hsa-miR-1908 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: HSPG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPG2 (see all 4) OriGene shRNA RFP: HSPG2 OriGene siRNA: HSPG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPG2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSPG2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPG2 (NM_005529)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPG2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSPG2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSPG2
		Search LifeMap BioReagents cell lines for HSPG2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPG2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11956183
GO:0008022	protein C-terminus binding	IPI	12604605
GO:0046872	metal ion binding	IEA	--

HSPG2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HSPG2:

Decreased Salmonella enterica

Decreased focal adhesion (FA)

Animal Models:
Mouse knock-outs for HSPG2: Hspg2^tm1Nid Hspg2^tm1Soin Hspg2^tm1Ref
15/21 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Hspg2) (see all 21):

behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary
embryogenesis	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging

HSPG2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/16 pathways (see all 16)
MPS VI - Maroteaux-Lamy syndrome	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Lipoprotein metabolism

	Lipoprotein metabolism	1.00			Lipid digestion, mobilization, and transport	0.56
	Chylomicron-mediated lipid transport	0.57

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for HSPG2

	Development FGF-family signaling
	Development FGFR signaling pathway

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSPG2 (see all 15)

	MAPK Signaling
	Inhibition of Matrix Metalloproteinases
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes

2 GeneGo (Thomson Reuters) Pathways for HSPG2

	Development FGF-family signaling
	Development FGFR signaling pathway

5/32 Reactome Pathways for HSPG2 (see all 32)

	Diseases associated with visual transduction
	Metabolism
	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	Chylomicron-mediated lipid transport

1 Kegg Pathway (Kegg details for HSPG2):

ECM-receptor interaction

HSPG2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/139 Interacting proteins for HSPG2 (P98160^{2, 3} ENSP00000363827⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 139)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRN	P28799²^,³, ENSP00000053867⁴	MINT-14457 MINT-14455 MINT-14456 I2D: score=3 STRING: ENSP00000053867
FBLN2	P98095³, ENSP00000384169⁴	I2D: score=3 STRING: ENSP00000384169
PDGFA	P04085³, ENSP00000346508⁴	I2D: score=3 STRING: ENSP00000346508
PRELP	P51888³, ENSP00000343924⁴	I2D: score=3 STRING: ENSP00000343924
APP	P05067³, ENSP00000284981⁴	I2D: score=2 STRING: ENSP00000284981

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001958	endochondral ossification	IEA	--
GO:0002062	chondrocyte differentiation	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006024	glycosaminoglycan biosynthetic process	TAS	--

HSPG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPG2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPG2

2 HMDB Compounds for HSPG2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Heparan sulfate	HHS 5 (see all 13)	9050-30-0	--

1 DrugBank Compound for HSPG2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Palifermin	FGF-7 (see all 5)	162394-19-6	target	--	9788974 14753849 10593896 16989989

10/137 Novoseek chemical compound relationships for HSPG2 gene (see all 137) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pl-cs	88.1	12	17526847 (2), 1613975 (1), 19541386 (1), 2128277 (1) (see all 9)
inositol 1,4,5 trisphosphate	88.1	129	9886839 (2), 17910604 (2), 2163545 (1), 1833464 (1) (see all 99)
pip2	85.8	79	8388752 (4), 18528787 (3), 19019830 (3), 1313007 (3) (see all 44)
phosphoinositide	83.2	101	2061301 (3), 8613709 (2), 10820192 (2), 7965720 (2) (see all 67)
u 73122	78	11	11071123 (1), 17680988 (1), 18237278 (1), 11424083 (1) (see all 9)
calcium	77.7	654	9827580 (5), 8759520 (5), 9685212 (5), 1651335 (4) (see all 99)
phosphatidylinositol	76.1	118	15234221 (2), 7961710 (2), 11557588 (2), 1327153 (2) (see all 66)
1,2-diacylglycerol	74.9	33	8209783 (2), 8392931 (2), 15108061 (2), 8428917 (2) (see all 14)
aminosteroid	72.9	6	7593299 (1), 8158247 (1), 9133633 (1), 8247012 (1) (see all 6)
phosphatidyl ethanol	72.8	6	8898346 (1), 8355574 (1), 9783907 (1), 8455209 (1)

Search CenterWatch for drugs/clinical trials and news about HSPG2 / PGBM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPG2 gene:

NM_005529.5

Unigene Cluster for HSPG2:

Heparan sulfate proteoglycan 2

Hs.562227 [show with all ESTs]

Unigene Representative Sequence: M85289

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000486901(uc001bfi.3) ENST00000374695(uc009vqe.1 uc001bfj.3 uc009vqd.3)

ENST00000481644 ENST00000469378 ENST00000426143 ENST00000471322 ENST00000374676

ENST00000453796 ENST00000493940 ENST00000427897 ENST00000498495 ENST00000480900

ENST00000412328 ENST00000374673 ENST00000439717 ENST00000430507

miRNA Products:		OriGene 3'-UTR Clone: HSPG2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPG2
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPG2 (see all 29):
		hsa-miR-1197 hsa-miR-520d-5p hsa-miR-15a hsa-miR-29a hsa-miR-29c hsa-miR-503 hsa-miR-1908 hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: HSPG2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPG2 (see all 4) OriGene shRNA RFP: HSPG2 OriGene siRNA: HSPG2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPG2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPG2 (NM_005529)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPG2
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSPG2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPG2

Additional cDNA sequence:

AB209851.1 AF479675.1 BC033152.1 BC109204.1 M64283.1 M85289.1 S76436.1 X62515.1

23 DOTS entries:

DT.97794852 DT.117676 DT.99943960 DT.100726160 DT.95321264 DT.97791668 DT.91673210 DT.99929478

DT.100790475 DT.40215860 DT.95203868 DT.95370971 DT.100042969 DT.121425196 DT.121425213 DT.86849248

DT.91762524 DT.95203873 DT.100044636 DT.100786383 DT.121425128 DT.95137172 DT.95203857

5 AceView cDNA sequences:

AA143738 BF872762 AA093907 R26043 AA143725

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACCCTCAC

About this image

HSPG2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPG2

SOURCE GeneReport for Unigene cluster: Hs.562227

UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160

Tissue specificity: Found in the basement membranes

SABiosciences Custom PCR Arrays for HSPG2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPG2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPG2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPG2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HSPG2 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSPG2¹	heparan sulfate proteoglycan 2	63.94(n) 58.71(a)		429806 NM_001001876.1 NP_001001876.1
lizard (Anolis carolinensis)	Reptilia	HSPG2⁶ HSPG2⁶	--	55(a) 34(a)	1 ↔ 1 possible ortholog	AAWZ02038048(552-10218) AAWZ02037520(1035-15339)
African clawed frog (Xenopus laevis)	Amphibia	Xl.22044²	Xenopus laevis transcribed sequence with weak similarity more	75.13(n)		BG729944.1
zebrafish (Danio rerio)	Actinopterygii	hspg2¹	heparan sulfate proteoglycan 2	57.14(n) 53.48(a)		565429 XM_003201208.1 XP_003201256.1
fruit fly (Drosophila melanogaster)	Insecta	EG:BACR25B3.1³	--	35(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	unc-52^{1 , 3}	Expression: muscle, mu_bod, pharynx, pharyngo-intestinal more³ Protein UNC-52¹	35(a)³ 41.76(n)¹ 30.34(a)¹		II(14643132-14662505)³ 175126¹ NM_064643.7¹ NP_497044.3¹

ENSEMBL Gene Tree for HSPG2 (if available)
TreeFam Gene Tree for HSPG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPG2 gene

VCAM1² IGSF10² HMCN1² ENSG00000215428² PTK7² HMCN2² MXRA5²

18/19 SIMAP similar genes for HSPG2 using alignment to 13 protein entries: PGBM_HUMAN (see all proteins) (see all similar genes):

F9 LRP4 PXDN LAMA3 CNTN5 LamA3

MUSK PXDNL CHL1 IGDCC3 HMCN2 LAMA4

VLDLR CNTN2 HMCN1 EYS AGRN LAMB4

HSPG2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HSPG2
PGOHUM00000237621

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115267963^1,2	C,F,	other	20457238(+)	`GTGGCG/AGGGGG`	2	/P /L	mis¹		2		WA NA	4664
rs59002896^1,2	C,	--	20391720(+)	`TCCTCG/AATGCT`	1	--	int¹		3		WA NA	240
rs112553046^1,2	C	--	20392207(+)	`CCCCTC/G/TGCGGG`	2	--	ut3¹		1		CSA	1
rs1049675^1,2	C,F,	--	20392286(-)	`NNNNAC/TGCCTG`	1	--	ut3¹ ese³		2		MN NA	304
rs12566171^1,2	H	--	20392499(+)	`TTCCAA/GATGGG`	1	--	ut3¹		0	--	--	--	--
rs116354301^1,2	C,F,	--	20392542(+)	`TGGGCG/AGGGCC`	1	--	ut3¹		1		WA	118
rs11552564^1,2	C	--	20392592(+)	`GAGTTG/AGGGTG`	1	--	ut3¹ ese³		1		NA	2
rs1049644^1,2	C,F,A,H,	--	20392652(-)	`CACCCC/GCTCCT`	1	--	ut3¹ ese³		9		EA MN NA CSA WA	2048
rs111306515^1,2	C	--	20393683(+)	`CTCCCA/G/TGCAGT`	1	--	spa¹		1		CSA	1
rs3736356^1,2	C,F,	--	20393934(-)	`GGCTCG/AGGCTT`	1	--	int¹		2		EA	1618

HapMap Linkage Disequilibrium report for HSPG2 (22148737 - 22263790 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for HSPG2
7 CNVs: 4216 29831 4215 3286 2045 47845 29830
Human Gene Mutation Database (HGMD): HSPG2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPG2

DNA2.0 Custom Variant and Variant Library Synthesis for HSPG2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPG2 for disorders           About GeneDecksing

OMIM gene information: 142461
OMIM disorders: 255800  224410
UniProtKB/Swiss-Prot: PGBM_HUMAN, P98160

Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1) [MIM:255800]; a rare autosomal recessive

disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia,

resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses

Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH) [MIM:224410]. The

dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are

two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have

a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The

endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by

hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage

20/169 diseases for HSPG2 (see all 169): About MalaCards

schwartz-jampel syndrome schwartz jampel syndrome type 1 dyssegmental dysplasia silverman-handmaker type dyssegmental dysplasia

tardive dyskinesia toxic epidermal necrolysis stevens-johnson syndrome myotonia

gas gangrene mixed connective tissue disease pthirus pubis infestation connective tissue disease

keratoconjunctivitis sicca sjogren-larsson syndrome dry eye syndrome spinal muscular atrophy

mitral valve prolapse multinodular goiter empty sella syndrome hypersensitivity reaction type ii disease

12 diseases from the University of Copenhagen DISEASES database for HSPG2:

Stevens-Johnson syndrome Mixed connective tissue disease Sjogren's syndrome Dry eye syndrome

Erythema multiforme Dermatomyositis Systemic scleroderma Dacryoadenitis

Hyperglobulinemic purpura Conjunctival degeneration Systemic lupus erythematosus Keratoconjunctivitis

10/91 Novoseek disease relationships for HSPG2 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dyssegmental dysplasia, silverman-handmaker type	76.1	2	11941538 (1), 11279527 (1)
sjogrens syndrome	69.3	51	2287968 (1), 1920970 (1), 1379949 (1), 8679304 (1) (see all 45)
annular erythema	52	11	9649694 (2), 2071745 (2), 9563275 (2), 8531373 (1)
sjogrens syndrome primary	50.4	11	9890678 (1), 1857996 (1), 9884552 (1), 11206359 (1) (see all 11)
schwartz-jampel syndrome	46.9	3	11038441 (1), 11941538 (1), 16927315 (1)
gas gangrene	42.5	3	10950774 (1), 16585634 (1), 18160514 (1)
xerostomia	40.1	10	19254127 (1), 19260540 (1), 16221495 (1), 9311000 (1) (see all 7)
mixed connective tissue disease	39.9	6	8101109 (1), 2222196 (1), 2050902 (1), 8144128 (1) (see all 6)
keratoconjunctivitis sicca	38.9	3	19260540 (1), 16918699 (1)
cholera	37.4	4	10542136 (2), 14715548 (1), 1707924 (1)

Genetic Association Database (GAD): HSPG2
Human Genome Epidemiology (HuGE) Navigator: HSPG2 (18 documents)

Export disorders for HSPG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSPG2 gene, integrated from 9 sources (see all 1224):
(articles sorted by number of sources associating them with HSPG2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-->p35 and identification of a BamHI restriction fragment length polymorphism. (PubMed id 1685141)^{1, 2, 3} Kallunki P....Tryggvason K. (1991)
An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease. (PubMed id 15211644)^{1, 4, 9} Rosenmann H....Abramsky O. (2004)
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. (PubMed id 12435733)^{1, 2, 9} Mongiat M.... Iozzo R.V. (2003)
Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia. (PubMed id 11941538)^{1, 3, 9} Arikawa-Hirasawa E....Yamada Y. (2002)
Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene. (PubMed id 11279527)^{1, 2, 9} Arikawa-Hirasawa E.... Yamada Y. (2001)
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. (PubMed id 19789387)^{1, 2} Nystrom A.... Iozzo R.V. (2009)
Integrin alpha2beta1 is the required receptor for endorepellin angiostatic activity. (PubMed id 18024432)^{1, 2} Woodall B.P....Iozzo R.V. (2008)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. (PubMed id 15591058)^{1, 2} Gonzalez E.M.... Iozzo R.V. (2005)
Lack of association between perlecan gene intron 6 BamHI polymorphism and risk of mitral valve prolapse in Taiwan Chinese. (PubMed id 14973356)^{1, 4} Chou H.T....Tsai F.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3339	HGNC: 5273	AceView: HSPG2.1	Ensembl:ENSG00000142798	euGenes: HUgn3339
ECgene: HSPG2	Kegg: 3339	H-InvDB: HSPG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSPG2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPG2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Perlecan
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HSPG2

Intellectual Property for HSPG2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HSPG2 gene:
Search GeneIP for patents involving HSPG2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPG2
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for HSPG2 (Endorepellin/Perlecan)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for HSPG2 (Endorepellin/Perlecan)

	Browse OriGene Antibodies		OriGene shRNA RFP for HSPG2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPG2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPG2
	OriGene Protein Over-expression Lysate for HSPG2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HSPG2		OriGene 3'-UTR Clone for HSPG2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPG2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HSPG2		OriGene Custom Protein Services for HSPG2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPG2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPG2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPG2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPG2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPG2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPG2

	GenScript Custom Purified and Recombinant Proteins Services for HSPG2		GenScript cDNA clones with any tag delivered in your preferred vector for HSPG2
	GenScript Custom Assay Services for HSPG2		GenScript Custom Superior Antibodies Services for HSPG2
	GenScript Custom overexpressing Cell Line Services for HSPG2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HSPG2 promoter
	Search Chromatin IP Primers for HSPG2
	RT² qPCR Primer Assay in human, mouse, rat HSPG2
	GNC Network for HSPG2
	SABiosciences PCR Arrays including human, mouse, rat HSPG2

Search Tocris compounds for HSPG2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HSPG2 antibodies
	HSPG2 proteins
	HSPG2 lysates

	Search for Antibodies for HSPG2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HSPG2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HSPG2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HSPG2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPG2

	SwitchGear 3'UTR luciferase reporter plasmids for HSPG2
	SwitchGear Promoter luciferase reporter plasmids for HSPG2

ThermoFisher Antibodies for HSPG2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSPG2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HSPG2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HSPG2 Gene

heparan sulfate proteoglycan 2

Aliases
for HSPG2 gene

Summaries
for HSPG2 gene

Genomic Views
for HSPG2 gene

Proteins
for HSPG2 gene

Protein Domains /
Families
for HSPG2 gene

Function
for HSPG2 gene

Pathways & Interactions
for HSPG2 gene

Drugs & Compounds
for HSPG2 gene

Transcripts
for HSPG2 gene

Expression
for HSPG2 gene

Orthologs
for HSPG2 gene

Paralogs
for HSPG2 gene

Genomic Variants
for HSPG2 gene

Disorders / Diseases
for HSPG2 gene

Publications
for HSPG2 gene

External Searches for HSPG2 gene

Genome Databases showing HSPG2 gene

Other Databases showing HSPG2 gene

Specialized Databases showing HSPG2 gene

Intellectual Property
for HSPG2 gene

Products
for HSPG2 gene

View Random Gene

HERPES
Hyperinsulinemia
Erythroleukemia
Nephropathy Membranous
Cystic Fibrosis
ANNULAR ERYTHEMA
allergy
Polyneuropathy
Ischemia
Atherosclerosis
Sjogrens Syndrome Primary
Antiphospholipid Syndrome
Gas Gangrene
Adenocarcinoma
BILIARY CIRRHOSIS PRIMARY
Cancer
Schwartz-Jampel Syndrome
Diabetes Mellitus Insulin-Dependent
Colorectal Carcinoma
multinodular goiter
Lymphoma
Purpura
RENAL DISEASE
Pancreatitis
Ehrlich Ascites Tumor
Multiple Sclerosis
Inflammation
Thyroid Neoplasms
Hepatitis
Hyperglycemia
Anemia
Bipolar Disorder
Retinal Degeneration
Renal Failure
Rheumatoid Arthritis
Pneumonia
Hepatitis Autoimmune
Cardiovascular Diseases
Tumors
Thrombosis
Necrosis
Autoimmunity
Acidosis
Sialadenitis
Hepatitis C
Neurofibrillary Tangles
Stevens-Johnson Syndrome
Autoimmune Diseases
Melanoma
BREAST CARCINOMA
Colon Cancer
Neurological Disorders
Xerostomia
Toxic Epidermal Necrolysis
Adenoma Follicular
DYSSEGMENTAL DYSPLASIA, SILVERMAN-HANDMAKER TYPE
Glioma
Skeletal dysplasia
HTLV-I Infections
Oligodendroglioma
Astrocytoma
INFARCT
Neuropil Threads
Thyroid Cancer
Mixed Connective Tissue Disease
Alzheimers Disease
Osteosarcoma
Dermatomyositis
Acidosis Renal Tubular
Pneumonia Interstitial
Sjogrens Syndrome
Cancer Lung
Connective Tissue Diseases
Hematologic Malignancies
Keratoconjunctivitis Sicca
Dry Eye Syndromes
Sjogrens Syndrome Secondary
Polyarthralgia
Eosinophilia
Adenoma
BEHCET DISEASE
Carcinoma Squamous Cell
Lung diseases
Erythema Multiforme
Dysautonomia
Cholera
Osteomalacia
Sclerosis Systemic
THYROID CARCINOMA
Polymyositis
Lupus Erythematosus Systemic

Advanced Search

Export list of displayed genes

HSPG2 Gene

heparan sulfate proteoglycan 2

Aliasesfor HSPG2 gene

Summariesfor HSPG2 gene

Genomic Viewsfor HSPG2 gene

Proteinsfor HSPG2 gene

Protein Domains /Familiesfor HSPG2 gene

Functionfor HSPG2 gene

Pathways & Interactionsfor HSPG2 gene

Drugs & Compoundsfor HSPG2 gene

Transcriptsfor HSPG2 gene

Expression for HSPG2 gene

Orthologsfor HSPG2 gene

Paralogsfor HSPG2 gene

Genomic Variantsfor HSPG2 gene

Disorders / Diseasesfor HSPG2 gene

Publicationsfor HSPG2 gene

External Searches for HSPG2 gene

Genome Databases showing HSPG2 gene

Other Databases showing HSPG2 gene

Specialized Databases showing HSPG2 gene

Intellectual Propertyfor HSPG2 gene

Productsfor HSPG2 gene

View Random Gene

Aliases
for HSPG2 gene

Summaries
for HSPG2 gene

Genomic Views
for HSPG2 gene

Proteins
for HSPG2 gene

Protein Domains /
Families
for HSPG2 gene

Function
for HSPG2 gene

Pathways & Interactions
for HSPG2 gene

Drugs & Compounds
for HSPG2 gene

Transcripts
for HSPG2 gene

Expression
for HSPG2 gene

Orthologs
for HSPG2 gene

Paralogs
for HSPG2 gene

Genomic Variants
for HSPG2 gene

Disorders / Diseases
for HSPG2 gene

Publications
for HSPG2 gene

Intellectual Property
for HSPG2 gene

Products
for HSPG2 gene