Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPE1-MOB4 Gene

Aliases for HSPE1-MOB4 Gene

  • HSPE1-MOB4 Readthrough 2 3 5
  • HSPE1-MOB4 Protein 3
  • HSPE1-PHOCN 3

External Ids for HSPE1-MOB4 Gene

Previous GeneCards Identifiers for HSPE1-MOB4 Gene

  • GC02U902474
  • GC02P198364

Summaries for HSPE1-MOB4 Gene

Entrez Gene Summary for HSPE1-MOB4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011]

GeneCards Summary for HSPE1-MOB4 Gene

HSPE1-MOB4 (HSPE1-MOB4 Readthrough) is a Protein Coding gene. An important paralog of this gene is MOB4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1-MOB4 Gene

Genomics for HSPE1-MOB4 Gene

Regulatory Elements for HSPE1-MOB4 Gene


Promoters for HSPE1-MOB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000605134 3 5201 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for HSPE1-MOB4 Gene

Chromosome:
2
Start:
197,499,997 bp from pter
End:
197,553,699 bp from pter
Size:
53,703 bases
Orientation:
Plus strand

Genomic View for HSPE1-MOB4 Gene

Genes around HSPE1-MOB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPE1-MOB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPE1-MOB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1-MOB4 Gene

Proteins for HSPE1-MOB4 Gene

  • Protein details for HSPE1-MOB4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R3N1
    Recommended name:
    Protein HSPE1-MOB4
    Protein Accession:
    S4R3N1

    Protein attributes for HSPE1-MOB4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29737 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPE1-MOB4 Gene

Post-translational modifications for HSPE1-MOB4 Gene

No Post-translational modifications

Other Protein References for HSPE1-MOB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPE1-MOB4 Gene

Domains & Families for HSPE1-MOB4 Gene

Protein Domains for HSPE1-MOB4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPE1-MOB4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Function for HSPE1-MOB4 Gene

Phenotypes for HSPE1-MOB4 Gene

genes like me logo Genes that share phenotypes with HSPE1-MOB4: view

Animal Model Products

miRNA for HSPE1-MOB4 Gene

miRTarBase miRNAs that target HSPE1-MOB4

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPE1-MOB4 Gene

Localization for HSPE1-MOB4 Gene

Gene Ontology (GO) - Cellular Components for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HSPE1-MOB4 Gene

Pathways & Interactions for HSPE1-MOB4 Gene

SuperPathways for HSPE1-MOB4 Gene

No Data Available

Interacting Proteins for HSPE1-MOB4 Gene

Gene Ontology (GO) - Biological Process for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Pathways by source and SIGNOR curated interactions for HSPE1-MOB4 Gene

Transcripts for HSPE1-MOB4 Gene

mRNA/cDNA for HSPE1-MOB4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1-MOB4 Gene

No ASD Table

Relevant External Links for HSPE1-MOB4 Gene

GeneLoc Exon Structure for
HSPE1-MOB4
ECgene alternative splicing isoforms for
HSPE1-MOB4

Expression for HSPE1-MOB4 Gene

mRNA expression in normal human tissues for HSPE1-MOB4 Gene

Protein differential expression in normal tissues from HIPED for HSPE1-MOB4 Gene

This gene is overexpressed in Fetal Brain (6.9) and Uterus (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for HSPE1-MOB4 Gene



Protein tissue co-expression partners for HSPE1-MOB4 Gene

genes like me logo Genes that share expression patterns with HSPE1-MOB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPE1-MOB4 Gene

Orthologs for HSPE1-MOB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPE1-MOB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOBKL3 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves MOB4 35
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mob4 35
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mob4 35
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30A5.3 35
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5204 35
  • 70 (a)
OneToMany
Species where no ortholog for HSPE1-MOB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPE1-MOB4 Gene

ENSEMBL:
Gene Tree for HSPE1-MOB4 (if available)
TreeFam:
Gene Tree for HSPE1-MOB4 (if available)

Paralogs for HSPE1-MOB4 Gene

Paralogs for HSPE1-MOB4 Gene

(3) SIMAP similar genes for HSPE1-MOB4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HSPE1-MOB4 Gene

genes like me logo Genes that share paralogs with HSPE1-MOB4: view

Variants for HSPE1-MOB4 Gene

Sequence variations from dbSNP and Humsavar for HSPE1-MOB4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs72466451 Pathogenic 197,498,763(-) CAAAG(A/G)TGTAA upstream-variant-2KB, reference, missense
rs11551349 Uncertain significance 197,498,822(-) TTTCG(C/G)CAGAT upstream-variant-2KB, reference, synonymous-codon
rs11551346 Benign 197,498,705(-) TTAGC(C/T)GATGC upstream-variant-2KB, reference, synonymous-codon
rs13165 Benign 197,499,794(+) GCGGC(A/G)GCAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs375104586 Benign 197,498,870(+) AAAAA(A/C/G)ATCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPE1-MOB4 Gene

Variant ID Type Subtype PubMed ID
esv3443077 CNV insertion 20981092
nsv1014881 CNV gain 25217958
nsv584156 CNV gain 21841781
nsv961921 CNV duplication 23825009
nsv963758 CNV duplication 23825009
nsv979161 CNV duplication 23825009
nsv979162 CNV duplication 23825009

Variation tolerance for HSPE1-MOB4 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPE1-MOB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPE1-MOB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Disorders for HSPE1-MOB4 Gene

Relevant External Links for HSPE1-MOB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPE1-MOB4

No disorders were found for HSPE1-MOB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPE1-MOB4 Gene

Publications for HSPE1-MOB4 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for HSPE1-MOB4 Gene

Sources for HSPE1-MOB4 Gene

Content
Loading form....