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HSPE1-MOB4 Gene

protein-coding   GIFtS: 18
GCID: GC02P198364

HSPE1-MOB4 Readthrough

  Search for HSPE1-MOB4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HSPE1-MOB4 Readthrough1 2
HSPE1-PHOCN2
HSPE1-MOB4 Protein2

External Ids:    HGNC: 491841   Entrez Gene: 1005292412   Ensembl: ENSG000002707577   UniProtKB: S4R3N14   

Export aliases for HSPE1-MOB4 gene to outside databases

Previous GC identifer: GC02U902474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPE1-MOB4 Gene:
This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock
10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through
transcript produces a fusion protein that shares sequence identity with each individual gene product. (provided
by RefSeq, Oct 2011)

GeneCards Summary for HSPE1-MOB4 Gene:
HSPE1-MOB4 (HSPE1-MOB4 readthrough) is a protein-coding gene. An important paralog of this gene is MOB4.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HSPE1-MOB4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPE1-MOB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

HSPE1-MOB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPE1-MOB4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198364:  view genomic region     (about GC identifiers)

Start:
198,364,721 bp from pter      End:
198,418,423 bp from pter
Size:
53,703 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: S4R3N1 (See protein sequence)
Recommended Name: Protein HSPE1-MOB4  
Size: 261 amino acids; 29737 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

Explore proteomics data for HSPE1-MOB4 at MOPED


See HSPE1-MOB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001189414.1  
ENSEMBL proteins: 
 ENSP00000474534  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR020818 Chaperonin_Cpn10
 IPR011032 GroES-like
 IPR018369 Chaprnonin_Cpn10_CS
 IPR005301 Mob1_phocein

Graphical View of Domain Structure for InterPro Entry S4R3N1

ProtoNet protein and cluster: S4R3N1

UniProtKB/TrEMBL: S4R3N1
Similarity: Belongs to the GroES chaperonin family


HSPE1-MOB4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005524ATP binding ----
GO:0019900kinase binding ----
     
HSPE1-MOB4 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005794Golgi apparatus ----
GO:0016020membrane ----

HSPE1-MOB4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSPE1-MOB4
Interactions:

    Search GeneGlobe Interaction Network for HSPE1-MOB4

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006457protein folding ----

HSPE1-MOB4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for HSPE1-MOB4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HSPE1-MOB4 gene: 
NM_001202485.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000604458
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HSPE1-MOB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HSPE1-MOB4 Expression
About this image

HSPE1-MOB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HSPE1-MOB4 Protein Expression
    Custom PCR Arrays for HSPE1-MOB4
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HSPE1-MOB4 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
93(a)
1 → many
37(7035102-7061783)
chicken
(Gallus gallus)
Aves MOB46
Gallus gallus MOB family member 4, phocein (MOB4),...
92(a)
1 → many
7(9738919-9748611)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
92(a)
1 → many
GL343436.1(652403-663588)
zebrafish
(Danio rerio)
Actinopterygii mob46
MOB family member 4, phocein
87(a)
1 → many
9(33340170-33346170) ENSDARG00000056085
fruit fly
(Drosophila melanogaster)
Insecta Mob46
--
76(a)
1 → many
2R(2582619-2584144)
worm
(Caenorhabditis elegans)
Secernentea C30A5.36
Protein C30A5.3 (C30A5.3) mRNA, complete cds
65(a)
1 → many
III(8225097-8226389) WBGene00016238


ENSEMBL Gene Tree for HSPE1-MOB4 (if available)
TreeFam Gene Tree for HSPE1-MOB4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HSPE1-MOB4 gene
MOB42  
3 SIMAP similar genes for HSPE1-MOB4 using alignment to 1 protein entry:     S4R3N1_HUMAN:
EPFP1    HSPE1    MOB4

HSPE1-MOB4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HSPE1-MOB4 (see all 196)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1402066791,2
--198368709(+) TCCAAC/TTTATA 1 -- int10--------
rs1831134431,2
--198368763(+) CCCAGG/TTACAC 1 -- int10--------
rs1877979221,2
--198368786(+) AATTGA/GGGGAA 1 -- int10--------
rs755214611,2
C--198368814(+) TTTTTC/TTTTTT 1 -- int10--------
rs1924834921,2
--198368879(+) TGTCAC/TGGCTC 1 -- int10--------
rs1840336241,2
--198368982(+) TGCTAA/GTTTTT 1 -- int10--------
rs1878981961,2
--198368998(+) TTTTGC/TAGAGA 1 -- int10--------
rs113109671,2
C--198369206(+) CCTTAT/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
rs101651691,2
C,F--198369208(+) TTATTT/ATTTTT 1 -- int12Minor allele frequency- A:0.50WA CSA 4
rs1165878251,2
F--198369307(+) GTGACC/TTCAAT 1 -- int11Minor allele frequency- T:0.03WA 118

HapMap Linkage Disequilibrium report for HSPE1-MOB4 (198364721 - 198418423 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for HSPE1-MOB4: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing HSPE1-MOB4
DNA2.0 Custom Variant and Variant Library Synthesis for HSPE1-MOB4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HSPE1-MOB4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with HSPE1-MOB4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100529241 HGNC: 49184 Ensembl:ENSG00000270757 euGenes: HUgn100529241 ECgene: HSPE1-MOB4
H-InvDB: HSPE1-MOB4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HSPE1-MOB4 gene:
Search GeneIP for patents involving HSPE1-MOB4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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