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Aliases for HSPE1-MOB4 Gene

Aliases for HSPE1-MOB4 Gene

  • HSPE1-MOB4 Readthrough 2 3
  • HSPE1-MOB4 Protein 3
  • HSPE1-PHOCN 3

External Ids for HSPE1-MOB4 Gene

Previous GeneCards Identifiers for HSPE1-MOB4 Gene

  • GC02U902474
  • GC02P198364

Summaries for HSPE1-MOB4 Gene

Entrez Gene Summary for HSPE1-MOB4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011]

GeneCards Summary for HSPE1-MOB4 Gene

HSPE1-MOB4 (HSPE1-MOB4 Readthrough) is a Protein Coding gene. An important paralog of this gene is MOB4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1-MOB4 Gene

Genomics for HSPE1-MOB4 Gene

Genomic Location for HSPE1-MOB4 Gene

Start:
197,499,997 bp from pter
End:
197,553,699 bp from pter
Size:
53,703 bases
Orientation:
Plus strand

Genomic View for HSPE1-MOB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPE1-MOB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1-MOB4 Gene

No data available for Regulatory Elements for HSPE1-MOB4 Gene

Proteins for HSPE1-MOB4 Gene

  • Protein details for HSPE1-MOB4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    S4R3N1
    Recommended name:
    Protein HSPE1-MOB4
    Protein Accession:
    S4R3N1
    Secondary Accessions:

    Protein attributes for HSPE1-MOB4 Gene

    Size:
    261 amino acids
    Molecular mass:
    29737 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPE1-MOB4 Gene

Proteomics data for HSPE1-MOB4 Gene at MOPED

Post-translational modifications for HSPE1-MOB4 Gene

No Post-translational modifications

Other Protein References for HSPE1-MOB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPE1-MOB4 Gene

Domains for HSPE1-MOB4 Gene

Protein Domains for HSPE1-MOB4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPE1-MOB4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Function for HSPE1-MOB4 Gene

Gene Ontology (GO) - Molecular Function for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSPE1-MOB4 Gene

Localization for HSPE1-MOB4 Gene

Gene Ontology (GO) - Cellular Components for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HSPE1-MOB4 Gene

Pathways for HSPE1-MOB4 Gene

SuperPathways for HSPE1-MOB4 Gene

No Data Available

Interacting Proteins for HSPE1-MOB4 Gene

Gene Ontology (GO) - Biological Process for HSPE1-MOB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
genes like me logo Genes that share ontologies with HSPE1-MOB4: view

No data available for Pathways by source for HSPE1-MOB4 Gene

Transcripts for HSPE1-MOB4 Gene

mRNA/cDNA for HSPE1-MOB4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1-MOB4 Gene

No ASD Table

Relevant External Links for HSPE1-MOB4 Gene

GeneLoc Exon Structure for
HSPE1-MOB4
ECgene alternative splicing isoforms for
HSPE1-MOB4

Expression for HSPE1-MOB4 Gene

mRNA expression in normal human tissues for HSPE1-MOB4 Gene

Integrated Proteomics: protein expression from MaxQB for HSPE1-MOB4 Gene

genes like me logo Genes that share expressions with HSPE1-MOB4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPE1-MOB4 Gene

Orthologs for HSPE1-MOB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPE1-MOB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MOBKL3 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves MOB4 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mob4 36
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Mob4 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30A5.3 36
  • 65 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5204 36
  • 70 (a)
OneToMany
Species with no ortholog for HSPE1-MOB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPE1-MOB4 Gene

ENSEMBL:
Gene Tree for HSPE1-MOB4 (if available)
TreeFam:
Gene Tree for HSPE1-MOB4 (if available)

Paralogs for HSPE1-MOB4 Gene

Paralogs for HSPE1-MOB4 Gene

Selected SIMAP similar genes for HSPE1-MOB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPE1-MOB4: view

Variants for HSPE1-MOB4 Gene

Sequence variations from dbSNP and Humsavar for HSPE1-MOB4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4040223 -- 197,512,965(-) ATCTC(A/C)AAAAA intron-variant
rs4850798 -- 197,505,652(+) tgtgt(A/G)tatat intron-variant
rs5837547 -- 197,512,947(+) ACTCT(-/T)TTTTT intron-variant
rs6434930 -- 197,504,646(+) GGCAT(C/T)TAATA intron-variant
rs6745524 -- 197,507,312(+) ttaat(A/G)ccatt intron-variant

Relevant External Links for HSPE1-MOB4 Gene

HapMap Linkage Disequilibrium report
HSPE1-MOB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPE1-MOB4 Gene

Disorders for HSPE1-MOB4 Gene

No disorders were found for HSPE1-MOB4 Gene.

No data available for UniProtKB/Swiss-Prot for HSPE1-MOB4 Gene

Publications for HSPE1-MOB4 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for HSPE1-MOB4 Gene

Sources for HSPE1-MOB4 Gene

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