Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPE1 Gene

protein-coding   GIFtS: 57
GCID: GC02P198328

heat shock 10kDa protein 1 (chaperonin 10)

(Previous name: heat shock 10kD protein 1 (chaperonin 10) )
 Explore 41 diseases affiliated with
HSPE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSPE1    

Aliases
for HSPE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock 10kDa Protein 1 (Chaperonin 10)1 2     10 KDa Chaperonin2 3
CPN101 2 3     EPF2 3
GROES1 2     HSP102 5
Heat Shock 10kD Protein 1 (Chaperonin 10)1 2     10 KDa Heat Shock Protein, Mitochondrial2
Chaperonin 102 3     Hsp103
Early-Pregnancy Factor2 3     

External Ids:    HGNC: 52691   Entrez Gene: 33362   Ensembl: ENSG000001155417   OMIM: 6001415   UniProtKB: P616043   

Export aliases for HSPE1 gene to outside databases

Previous GC identifers: GC02P196563 GC02P197078 GC02P198567 GC02P198190 GC02P198073 GC02P190217


Summaries
for HSPE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSPE1:
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric
ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances
protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head
orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the
neighboring locus MOBKL3.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: CH10_HUMAN, P61604
Function: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds
to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter

Gene Wiki entry for HSPE1 (GroES)


Genomic Views
for HSPE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPE1 gene promoter:
         c-Fos   p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

HSPE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPE1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198328:  view genomic region     (about GC identifiers)

Start:
 198,364,718 bp from pter      End:
 198,368,187 bp from pter
Size:
 3,470 bases      Orientation:
 plus strand

Proteins
for HSPE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CH10_HUMAN, P61604 (See protein sequence)
Recommended Name: 10 kDa heat shock protein, mitochondrial  
Size: 102 amino acids; 10932 Da
Subunit: Homohexamer
Subcellular location: Mitochondrion matrix
Mass spectrometry: Mass=10843.5; Mass_error=0.2; Method=Electrospray; Range=2-102; Source=PubMed:7912672;
Secondary accessions: O95421 Q04984 Q53X54 Q9UDH0

Explore the universe of human proteins at neXtProt for HSPE1: NX_P61604

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61604

    • HSPE1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002148.1  
    ENSEMBL proteins: 
     ENSP00000233893   ENSP00000387101   ENSP00000386447  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HSPE1
    OriGene Protein Over-expression Lysate: HSPE1
    OriGene Custom Protein Services for HSPE1 
    GenScript Custom Purified and Recombinant Proteins Services for HSPE1
    Novus Biologicals HSPE1 Proteins
    Novus Biologicals HSPE1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HSPE1
    Uscn Proteins for HSPE1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix IEA--


    HSPE1 for ontologies           About GeneDecksing



    HSPE1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HSPE1 (HSP10/EPF)
    OriGene Antibodies (see all 2): HSPE1
    OriGene Custom Antibody Services for HSPE1 
    GenScript Custom Superior Antibodies Services for HSPE1
    Novus Biologicals HSPE1 Antibodies
    Abcam antibodies for HSPE1 
    Uscn Antibodies for HSPE1
    ThermoFisher Antibodies for HSPE1

    Assay Products for HSPE1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPE1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HSPE1

    Protein Domains /
    Families
    for HSPE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSPE1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR020818 Chaperonin_Cpn10
     IPR011032 GroES-like
     IPR018369 Chaprnonin_Cpn10_CS

    Graphical View of Domain Structure for InterPro Entry P61604

    ProtoNet protein and cluster: P61604

    UniProtKB/Swiss-Prot: CH10_HUMAN, P61604
    Similarity: Belongs to the GroES chaperonin family


    Function
    for HSPE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CH10_HUMAN, P61604
    Function: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds
    to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
    Induction: By stress

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HSPE1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPE1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPE1:
    hsa-miR-206 hsa-miR-3673 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: HSPE1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPE1 (see all 7)
    OriGene shRNA RFP: HSPE1
    OriGene siRNA: HSPE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPE1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSPE1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HSPE1 (NM_002157)
    Sino Biological Human cDNA Clone for HSPE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPE1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HSPE1
    Search LifeMap BioReagents cell lines for HSPE1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HSPE1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18319262
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding NAS12483302
    GO:0051087chaperone binding ISS--


    HSPE1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HSPE1:
     Decreased viability 


    Pathways & Interactions
    for HSPE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/78 Interacting proteins for HSPE1 (P616041, 2, 3 ENSP000002338934) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932, 3MINT-63939 I2D: score=4 
    C14orf1Q9UKR52, 3MINT-63946 I2D: score=4 
    SAT1P216732, 3MINT-63565 I2D: score=4 
    TLE1Q047242, 3MINT-63940 I2D: score=4 
    UNC119Q134322, 3MINT-63941 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS10205158
    GO:0006950response to stress ----
    GO:0006986response to unfolded protein TAS7698325


    HSPE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSPE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPE1
    10/23 Novoseek chemical compound relationships for HSPE1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amp-pnp 54.2 4 8943246 (1), 8095403 (1), 8618836 (1)
    8-azido-atp 52.4 4 7867782 (2), 7789507 (1)
    atp 51.8 63 8947033 (3), 8608602 (3), 15347650 (3), 9571049 (3) (see all 24)
    mgatp 46.1 7 1974461 (1), 7908292 (1), 7911087 (1), 7789507 (1)
    malate 43.9 2 9102459 (1), 16375456 (1)
    adp 43.6 24 15347650 (3), 7913554 (2), 8947033 (1), 8943246 (1) (see all 10)
    guanidine hydrochloride 37.1 5 18329043 (3), 11152122 (1)
    pyruvate 16.4 5 17552551 (2), 17523614 (1), 10748134 (1), 15822913 (1)
    glyceraldehyde 3-phosphate 16.4 2 10196153 (1)
    acyl-coa 8.51 1 8104486 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPE1 / CH10 

    Transcripts
    for HSPE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSPE1 gene: 
    NM_002157.2  

    Unigene Cluster for HSPE1:

    Heat shock 10kDa protein 1 (chaperonin 10)
    Hs.1197  [show with all ESTs]
    Unigene Representative Sequence: BU517060
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233893(uc002uul.3) ENST00000409729 ENST00000473395 ENST00000409468
    ENST00000495200 ENST00000465573 ENST00000463841

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HSPE1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPE1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPE1:
    hsa-miR-206 hsa-miR-3673 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: HSPE1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPE1 (see all 7)
    OriGene shRNA RFP: HSPE1
    OriGene siRNA: HSPE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPE1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HSPE1 (NM_002157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPE1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPE1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPE1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPE1

    Additional cDNA sequence: 

    AK312104.1 BC023518.2 CR407688.1 U07550.1 X75821.1 

    24/40 DOTS entries (see all 40):

    DT.100044974  DT.92461991  DT.100884127  DT.95277215  DT.121018706  DT.95260889  DT.121018720  DT.101986431 
    DT.418296  DT.453986  DT.121018595  DT.92461973  DT.99943534  DT.121018567  DT.97862287  DT.100044972 
    DT.100884136  DT.121018475  DT.121018742  DT.92433271  DT.100884133  DT.120745414  DT.121018518  DT.100884126 

    24/780 AceView cDNA sequences (see all 780):

    CB217368 AI375609 AI149276 BU187061 BM559301 BQ439041 BG180939 AW051851 
    AA348926 N78825 AI521722 CA309000 AA932646 AI363069 BM661622 CD102733 
    AF151853 AA459269 R37012 AA962519 AI042038 AW005438 BP377734 BE908962 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -                                       
    SP2:                          -                 -                     
    SP3:                          -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for HSPE1

    Expression
    for HSPE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATAATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HSPE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPE1

    SOURCE GeneReport for Unigene cluster: Hs.1197
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPE1: 
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPE1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPE1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPE1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPE1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HSPE1

    Orthologs
    for HSPE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HSPE1 gene from 11/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hspe11 , 5 heat shock protein 1 (chaperonin 10)1, 5 90.52(n)1
    96.08(a)1    		   1 (28.02 cM)5
    155281  NM_008303.41  NP_032329.11 
     550881325 
    chicken
    (Gallus gallus)    		 Aves HSPE11 heat shock 10kDa protein 1 (chaperonin 10) 80.07(n)
    87.25(a)    		   395948  NM_205067.1  NP_990398.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HSPE16
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343436.1(676964-685290)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480339982   -- 78.35(n)    48033998 
    zebrafish
    (Danio rerio)    		 Actinopterygii hspe12 heat shock 10kD protein 1 (chaperonin 10) 71.01(n)   58041  AF273739.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG112671 CG11267 54.04(n)
    57.89(a)    		   39476  NM_140365.2  NP_648622.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y22D7AL.101 , 3 Protein Y22D7AL.101 62(a)3
    60.94(n)1
    62.63(a)1    		   III(1689194-1690741)3
    1753151  NM_065027.51  NP_497428.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HSP10(YOR020C)4
    HSP101    		 Mitochondrial matrix co-chaperonin that inhibits the more4
    Hsp10p1    		 50.54(n)1
    47.31(a)1    		   15(370844-370524)4
    8541851, 4  NP_014663.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CPN101 chaperonin 10 53.85(n)
    53.85(a)    		   838063  NM_101367.2  NP_563961.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g06417001 hypothetical protein 52.98(n)
    50.53(a)    		   4344071  NM_001066966.1  NP_001060431.1 


    ENSEMBL Gene Tree for HSPE1 (if available)
    TreeFam Gene Tree for HSPE1 (if available) 

    Paralogs
    for HSPE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPE1 gene
    1 SIMAP similar gene for HSPE1 using alignment to 3 protein entries:     CH10_HUMAN (see all proteins):
    EPFP1

    HSPE1 for paralogs           About GeneDecksing


    5/28 Pseudogenes.org Pseudogenes for HSPE1 (see all 28)
    PGOHUM00000238813 PGOHUM00000242499 PGOHUM00000239568 PGOHUM00000239670 PGOHUM00000239956


    Genomic Variants
    for HSPE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/33 NCBI SNPs in HSPE1 are shown (see all 33)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs67466611,2
    		C,--198367002(+) CTAATG/ATNNNN 2 -- int13Minor allele frequency- A:0.17NA WA 122
    rs1839720001,2
    		--198367112(+) GCCTCA/GGGCTT 2 -- int10--------
    rs10726121,2
    		C,--198367148(-) ACGGCG/ATTTAC 2 -- int12Minor allele frequency- A:0.02NA WA 120
    rs1476398691,2
    		--198367149(+) TAAACA/GCCGTT 2 -- int10--------
    rs1887068551,2
    		--198367177(+) ACTGCA/GTTGTT 2 -- int10--------
    rs1423098561,2
    		--198367183(+) TTGTTC/GTAGTT 2 -- int10--------
    rs7168001,2
    		C,A,H,--198367342(+) AAAAAC/TTTTAA 2 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1386050201,2
    		--198367353(+) ATTTTC/TGTATG 2 -- int10--------
    rs1807315141,2
    		--198367550(+) TTAAGC/TCACTG 2 -- int10--------
    rs1860061491,2
    		--198367621(+) TGAGTC/TGTATC 2 -- int10--------

    HapMap Linkage Disequilibrium report for HSPE1 (198364718 - 198368187 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSPE1: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPE1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPE1

    Disorders / Diseases
    for HSPE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSPE1 for disorders           About GeneDecksing

    OMIM gene information: 600141    OMIM disorders: --

    20/41 diseases for HSPE1 (see all 41):    About MalaCards
    acyl-coa dehydrogenase    maple syrup urine disease    spastic paraplegia    hereditary spastic paraplegia
    atrial fibrillation    spontaneous abortion    carrion's disease    polycystic ovary syndrome
    paraplegia    cystic fibrosis    tularemia    rheumatoid arthritis
    spasticity    multiple sclerosis    endometrial cancer    choriocarcinoma
    pandas    arthritis    periodontitis    huntington's disease

    10/23 Novoseek disease relationships for HSPE1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 56.2 39 8608635 (2), 15059967 (2), 11810192 (2), 17348040 (2) (see all 27)
    abortion threatened 55.8 1 8329108 (1)
    abortion missed 44.5 1 8150373 (1)
    tuberculosis 43.1 36 12837802 (4), 9536120 (2), 11807250 (2), 7592820 (2) (see all 18)
    miscarriage recurrent 41.9 3 7959861 (2), 1720719 (1)
    endometrial cancer 21.1 2 17523614 (1), 16808467 (1)
    multiple sclerosis 15.4 8 19039022 (2), 9893026 (1), 18465663 (1)
    choriocarcinoma 12.7 1 8390229 (1)
    mimicry 10.3 1 7779079 (1)
    metastasis 3.4 4 16253146 (4)

    Human Genome Epidemiology (HuGE) Navigator: HSPE1 (2 documents)

    Export disorders for HSPE1 gene to outside databases

    Publications
    for HSPE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPE1 gene, integrated from 9 sources (see all 219):
    (articles sorted by number of sources associating them with HSPE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of human chaperonin 10 homologue. (PubMed id 7914093)1, 2, 3, 9 Monzini N.... Modena D. (1994)
    2. The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. (PubMed id 7912672)1, 2, 9 Cavanagh A.C. and Morton H. (1994)
    3. Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10. (PubMed id 7698325)1, 3, 9 Legname G....Modena D. (1995)
    4. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. (PubMed id 12483302)1, 2, 9 Hansen J.J.... Gregersen N. (2003)
    5. Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10. (PubMed id 7916212)1, 2, 9 Chen J.J.... Androphy E.J. (1994)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family. (PubMed id 10763410)1, 2 Summers K.M.... Cavanagh A.C. (1998)
    8. Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence. (PubMed id 18329043)1, 9 Yagi H....Kawata Y. (2008)
    9. Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway. (PubMed id 15059967)1, 9 Lin K.M....Dillmann W.H. (2004)
    10. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. (PubMed id 12967636)1, 9 Shan Y.X....Wang P.H. (2003)

    External Searches for HSPE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSPE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3336 HGNC: 5269 AceView: HSPE1andPREI3 Ensembl:ENSG00000115541 euGenes: HUgn3336
    ECgene: HSPE1 H-InvDB: HSPE1

    Other Databases showing HSPE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSPE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPE1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HSPE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSPE1 gene:
    Search GeneIP for patents involving HSPE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HSPE1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HSPE1 (HSP10/EPF)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HSPE1   OriGene shRNA RFP for HSPE1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPE1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPE1  
     OriGene Protein Over-expression Lysate for HSPE1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HSPE1   OriGene 3'-UTR Clone for HSPE1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPE1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HSPE1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPE1   OriGene Custom Protein Services for HSPE1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPE1
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPE1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPE1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPE1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPE1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPE1
     GenScript Custom Purified and Recombinant Proteins Services for HSPE1 GenScript cDNA clones with any tag delivered in your preferred vector for HSPE1
     GenScript Custom Assay Services for HSPE1 GenScript Custom Superior Antibodies Services for HSPE1
     GenScript Custom overexpressing Cell Line Services for HSPE1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSPE1 promoter
     Search Chromatin IP Primers for HSPE1
     RT2 qPCR Primer Assay in human, mouse, rat HSPE1
     GNC Network for HSPE1
     SABiosciences PCR Arrays including human, mouse, rat HSPE1
     Search Tocris compounds for HSPE1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for HSPE1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSPE1 antibodies
     HSPE1 proteins
     HSPE1 lysates
     Antibodies for HSPE1
     See all of Abcam's Antibodies, Kits and Proteins for HSPE1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSPE1




     HSPE1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HSPE1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HSPE1
     SwitchGear 3'UTR luciferase reporter plasmids for HSPE1
     SwitchGear Promoter luciferase reporter plasmids for HSPE1
     ThermoFisher Antibodies for HSPE1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPE1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HSPE1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4