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Aliases for HSPE1 Gene

Aliases for HSPE1 Gene

  • Heat Shock Protein Family E (Hsp10) Member 1 2 3 5
  • Chaperonin 10 2 3 4
  • Heat Shock 10kD Protein 1 (Chaperonin 10) 2 3
  • Heat Shock 10kDa Protein 1 2 3
  • Early Pregnancy Factor 2 3
  • Early-Pregnancy Factor 3 4
  • 10 KDa Chaperonin 3 4
  • HSP10 3 4
  • CPN10 3 4
  • EPF 3 4
  • GROES 3

External Ids for HSPE1 Gene

Previous GeneCards Identifiers for HSPE1 Gene

  • GC02P196563
  • GC02P197078
  • GC02P198328
  • GC02P198567
  • GC02P198190
  • GC02P198073
  • GC02P190217

Summaries for HSPE1 Gene

Entrez Gene Summary for HSPE1 Gene

  • This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

GeneCards Summary for HSPE1 Gene

HSPE1 (Heat Shock Protein Family E (Hsp10) Member 1) is a Protein Coding gene. Diseases associated with HSPE1 include exocervical carcinoma and sennetsu fever. GO annotations related to this gene include poly(A) RNA binding and chaperone binding.

UniProtKB/Swiss-Prot for HSPE1 Gene

  • Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

Gene Wiki entry for HSPE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1 Gene

Genomics for HSPE1 Gene

Regulatory Elements for HSPE1 Gene

Enhancers for HSPE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPE1 on UCSC Golden Path with GeneCards custom track

Promoters for HSPE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPE1 Gene

Chromosome:
2
Start:
197,499,994 bp from pter
End:
197,503,463 bp from pter
Size:
3,470 bases
Orientation:
Plus strand

Genomic View for HSPE1 Gene

Genes around HSPE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1 Gene

Proteins for HSPE1 Gene

  • Protein details for HSPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61604-CH10_HUMAN
    Recommended name:
    10 kDa heat shock protein, mitochondrial
    Protein Accession:
    P61604
    Secondary Accessions:
    • O95421
    • Q04984
    • Q53X54
    • Q9UDH0

    Protein attributes for HSPE1 Gene

    Size:
    102 amino acids
    Molecular mass:
    10932 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for HSPE1 Gene

neXtProt entry for HSPE1 Gene

Proteomics data for HSPE1 Gene at MOPED

Post-translational modifications for HSPE1 Gene

  • Ubiquitination at Lys 8 and Lys 28
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPE1 Gene

Domains & Families for HSPE1 Gene

Gene Families for HSPE1 Gene

Protein Domains for HSPE1 Gene

Suggested Antigen Peptide Sequences for HSPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61604

UniProtKB/Swiss-Prot:

CH10_HUMAN :
  • Belongs to the GroES chaperonin family.
Family:
  • Belongs to the GroES chaperonin family.
genes like me logo Genes that share domains with HSPE1: view

Function for HSPE1 Gene

Molecular function for HSPE1 Gene

UniProtKB/Swiss-Prot Function:
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
UniProtKB/Swiss-Prot Induction:
By stress.

Gene Ontology (GO) - Molecular Function for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0051082 unfolded protein binding NAS 7916212
genes like me logo Genes that share ontologies with HSPE1: view

Phenotypes for HSPE1 Gene

genes like me logo Genes that share phenotypes with HSPE1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HSPE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPE1 Gene

Localization for HSPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPE1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPE1 Gene COMPARTMENTS Subcellular localization image for HSPE1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
chloroplast 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPE1: view

Pathways & Interactions for HSPE1 Gene

SuperPathways for HSPE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HSPE1 Gene

Drugs & Compounds for HSPE1 Gene

(11) Drugs for HSPE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for HSPE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPE1: view

Transcripts for HSPE1 Gene

Unigene Clusters for HSPE1 Gene

Heat shock 10kDa protein 1 (chaperonin 10):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for HSPE1 Gene

GeneLoc Exon Structure for
HSPE1
ECgene alternative splicing isoforms for
HSPE1

Expression for HSPE1 Gene

mRNA expression in normal human tissues for HSPE1 Gene

mRNA differential expression in normal tissues according to GTEx for HSPE1 Gene

This gene is overexpressed in Liver (x4.2) and Adrenal Gland (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPE1 Gene



SOURCE GeneReport for Unigene cluster for HSPE1 Gene Hs.1197

genes like me logo Genes that share expression patterns with HSPE1: view

Protein tissue co-expression partners for HSPE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPE1 Gene

Orthologs for HSPE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPE1 35
  • 93.14 (n)
  • 100 (a)
HSPE1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPE1 35
  • 92.81 (n)
  • 100 (a)
HSPE1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspe1 35
  • 90.52 (n)
  • 96.08 (a)
Hspe1 16
Hspe1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspe1 35
  • 89.54 (n)
  • 98.04 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPE1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPE1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPE1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPE1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPE1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspe1 35
  • 78.1 (n)
  • 87.25 (a)
Str.10777 35
zebrafish
(Danio rerio)
Actinopterygii hspe1 35
  • 70.71 (n)
  • 82.83 (a)
hspe1 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11267 36
  • 52 (a)
OneToMany
CG9920 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y22D7AL.10 37
  • 62 (a)
Y22D7AL.10 35
  • 60.94 (n)
  • 62.63 (a)
Y22D7AL.10 36
  • 57 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL235W 35
  • 45.49 (n)
  • 47.92 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09307g 35
  • 50.51 (n)
  • 44.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP10 35
  • 50 (n)
  • 45.83 (a)
HSP10 36
  • 42 (a)
OneToOne
HSP10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CPN10 35
  • 53.62 (n)
  • 53.26 (a)
rice
(Oryza sativa)
Liliopsida Os07g0641700 35
  • 52.98 (n)
  • 50.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04334 35
  • 50.84 (n)
  • 44.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp10 35
  • 48.94 (n)
  • 43.62 (a)
Species with no ortholog for HSPE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPE1 Gene

ENSEMBL:
Gene Tree for HSPE1 (if available)
TreeFam:
Gene Tree for HSPE1 (if available)

Paralogs for HSPE1 Gene

(2) SIMAP similar genes for HSPE1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSPE1: view

No data available for Paralogs for HSPE1 Gene

Variants for HSPE1 Gene

Variation tolerance for HSPE1 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPE1 Gene

HapMap Linkage Disequilibrium report
HSPE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HSPE1 Gene

Disorders for HSPE1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HSPE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exocervical carcinoma
  • carcinoma of exocervix
sennetsu fever
  • sennetsu ehrlichiosis
leprosy
  • leprosy, susceptibility to
carrion's disease
  • carrion disease
- elite association - COSMIC cancer census association via MalaCards
Search HSPE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPE1

Genetic Association Database (GAD)
HSPE1
Human Genome Epidemiology (HuGE) Navigator
HSPE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPE1
genes like me logo Genes that share disorders with HSPE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPE1 Gene

Publications for HSPE1 Gene

  1. Identification and cloning of human chaperonin 10 homologue. (PMID: 7914093) Monzini N. … Modena D. (Biochim. Biophys. Acta 1994) 2 3 4 23 67
  2. Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10. (PMID: 7698325) Legname G. … Modena D. (FEBS Lett. 1995) 2 3 23
  3. Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3. (PMID: 19142874) Dobocan M.C. … Congote L.F. (J. Cell. Physiol. 2009) 3 23
  4. Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence. (PMID: 18329043) Yagi H. … Kawata Y. (J. Mol. Biol. 2008) 3 23
  5. Kinetic folding and assembly mechanisms differ for two homologous heptamers. (PMID: 16979655) Luke K. … Wittung-Stafshede P. (J. Mol. Biol. 2006) 3 23

Products for HSPE1 Gene

Sources for HSPE1 Gene

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