Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPE1 Gene

Aliases for HSPE1 Gene

  • Heat Shock Protein Family E (Hsp10) Member 1 2 3 5
  • Chaperonin 10 2 3 4
  • Heat Shock 10kD Protein 1 (Chaperonin 10) 2 3
  • Heat Shock 10kDa Protein 1 2 3
  • Early-Pregnancy Factor 3 4
  • 10 KDa Chaperonin 3 4
  • HSP10 3 4
  • CPN10 3 4
  • EPF 3 4
  • 10 KDa Heat Shock Protein, Mitochondrial 3
  • Early Pregnancy Factor 2
  • GROES 3

External Ids for HSPE1 Gene

Previous GeneCards Identifiers for HSPE1 Gene

  • GC02P196563
  • GC02P197078
  • GC02P198328
  • GC02P198567
  • GC02P198190
  • GC02P198073
  • GC02P190217

Summaries for HSPE1 Gene

Entrez Gene Summary for HSPE1 Gene

  • This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

GeneCards Summary for HSPE1 Gene

HSPE1 (Heat Shock Protein Family E (Hsp10) Member 1) is a Protein Coding gene. Diseases associated with HSPE1 include Exocervical Carcinoma and Sennetsu Fever. GO annotations related to this gene include poly(A) RNA binding and chaperone binding.

UniProtKB/Swiss-Prot for HSPE1 Gene

  • Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

Gene Wiki entry for HSPE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPE1 Gene

Genomics for HSPE1 Gene

Regulatory Elements for HSPE1 Gene

Enhancers for HSPE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F197478 0.2 Ensembl 12.2 -21.1 -21109 0.6 TAL1 REST ZNF316 KLF16 IKZF1 TRIM24 ETV6 EMSY MAFK SPI1 HSPE1 HSPD1 RNU6-1029P SF3B1 ENSG00000202434 GC02P197477
GH02F197460 0.5 ENCODE 11.7 -38.8 -38840 0.9 GATA3 TAL1 FOS FOSL2 KLF4 ZBTB40 SF3B1 HSPE1 HSPD1 ENSG00000202434 COQ10B GC02P197477
GH02F197451 0.6 ENCODE 11.6 -46.6 -46616 4.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 HSPE1 HSPD1 GTF3C3 ENSG00000202434 BOLL ANKRD44 PLCL1 COQ10B RNU6-1029P
GH02F197495 0.2 ENCODE 0.8 -0.5 -485 7.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NPM1P46 GTF3C3 RNU6-1029P SF3B1 ANKRD44 ENSG00000202434 PLCL1 COQ10B HSPE1 GC02P197477
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSPE1 on UCSC Golden Path with GeneCards custom track

Promoters for HSPE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000605134 6 5201 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for HSPE1 Gene

Chromosome:
2
Start:
197,499,994 bp from pter
End:
197,503,463 bp from pter
Size:
3,470 bases
Orientation:
Plus strand

Genomic View for HSPE1 Gene

Genes around HSPE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPE1 Gene

Proteins for HSPE1 Gene

  • Protein details for HSPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61604-CH10_HUMAN
    Recommended name:
    10 kDa heat shock protein, mitochondrial
    Protein Accession:
    P61604
    Secondary Accessions:
    • O95421
    • Q04984
    • Q53X54
    • Q9UDH0

    Protein attributes for HSPE1 Gene

    Size:
    102 amino acids
    Molecular mass:
    10932 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for HSPE1 Gene

neXtProt entry for HSPE1 Gene

Post-translational modifications for HSPE1 Gene

  • Ubiquitination at Lys 8 and Lys 28
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HSPE1
  • Cloud-Clone Corp. Antibodies for HSPE1

Protein Products

  • Abcam proteins for HSPE1

No data available for DME Specific Peptides for HSPE1 Gene

Domains & Families for HSPE1 Gene

Gene Families for HSPE1 Gene

Protein Domains for HSPE1 Gene

Suggested Antigen Peptide Sequences for HSPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61604

UniProtKB/Swiss-Prot:

CH10_HUMAN :
  • Belongs to the GroES chaperonin family.
Family:
  • Belongs to the GroES chaperonin family.
genes like me logo Genes that share domains with HSPE1: view

Function for HSPE1 Gene

Molecular function for HSPE1 Gene

UniProtKB/Swiss-Prot Function:
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
UniProtKB/Swiss-Prot Induction:
By stress.

Gene Ontology (GO) - Molecular Function for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9989505
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IBA --
GO:0051082 unfolded protein binding NAS 7916212
genes like me logo Genes that share ontologies with HSPE1: view

Phenotypes for HSPE1 Gene

genes like me logo Genes that share phenotypes with HSPE1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HSPE1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPE1 Gene

Localization for HSPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPE1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPE1 Gene COMPARTMENTS Subcellular localization image for HSPE1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
chloroplast 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion ISS --
GO:0005759 mitochondrial matrix IEA,IBA --
GO:0016020 membrane IDA 16210410
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSPE1: view

Pathways & Interactions for HSPE1 Gene

SuperPathways for HSPE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006457 protein folding IEA,TAS 7698325
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process NAS 10205158
GO:0006986 response to unfolded protein TAS 7698325
GO:0051085 chaperone mediated protein folding requiring cofactor IBA --
genes like me logo Genes that share ontologies with HSPE1: view

No data available for Pathways by source and SIGNOR curated interactions for HSPE1 Gene

Drugs & Compounds for HSPE1 Gene

(12) Drugs for HSPE1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for HSPE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPE1: view

Transcripts for HSPE1 Gene

Unigene Clusters for HSPE1 Gene

Heat shock 10kDa protein 1 (chaperonin 10):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for HSPE1 Gene

GeneLoc Exon Structure for
HSPE1
ECgene alternative splicing isoforms for
HSPE1

Expression for HSPE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPE1 Gene

mRNA differential expression in normal tissues according to GTEx for HSPE1 Gene

This gene is overexpressed in Liver (x4.2) and Adrenal Gland (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPE1 Gene



Protein tissue co-expression partners for HSPE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPE1 Gene:

HSPE1

SOURCE GeneReport for Unigene cluster for HSPE1 Gene:

Hs.1197
genes like me logo Genes that share expression patterns with HSPE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPE1 Gene

Orthologs for HSPE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPE1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPE1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPE1 34 35
  • 93.14 (n)
dog
(Canis familiaris)
Mammalia HSPE1 34 35
  • 92.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSPE1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspe1 34 16 35
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia Hspe1 34
  • 89.54 (n)
chicken
(Gallus gallus)
Aves HSPE1 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPE1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspe1 34
  • 78.1 (n)
Str.10777 34
zebrafish
(Danio rerio)
Actinopterygii hspe1 34 35
  • 70.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11267 35
  • 52 (a)
OneToMany
CG9920 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y22D7AL.10 36 34 35
  • 60.94 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E09307g 34
  • 50.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP10 34 35 37
  • 50 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL235W 34
  • 45.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CPN10 34
  • 53.62 (n)
rice
(Oryza sativa)
Liliopsida Os07g0641700 34
  • 52.98 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04334 34
  • 50.84 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp10 34
  • 48.94 (n)
Species where no ortholog for HSPE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPE1 Gene

ENSEMBL:
Gene Tree for HSPE1 (if available)
TreeFam:
Gene Tree for HSPE1 (if available)

Paralogs for HSPE1 Gene

No data available for Paralogs for HSPE1 Gene

Variants for HSPE1 Gene

Sequence variations from dbSNP and Humsavar for HSPE1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs72466451 Pathogenic 197,498,763(-) CAAAG(A/G)TGTAA upstream-variant-2KB, reference, missense
rs11551349 Uncertain significance 197,498,822(-) TTTCG(C/G)CAGAT upstream-variant-2KB, reference, synonymous-codon
rs11551346 Benign 197,498,705(-) TTAGC(C/T)GATGC upstream-variant-2KB, reference, synonymous-codon
rs13165 Benign 197,499,794(+) GCGGC(A/G)GCAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs375104586 Benign 197,498,870(+) AAAAA(A/C/G)ATCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPE1 Gene

Variant ID Type Subtype PubMed ID
nsv1014881 CNV gain 25217958
nsv961921 CNV duplication 23825009
nsv979161 CNV duplication 23825009

Variation tolerance for HSPE1 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPE1 Gene

Disorders for HSPE1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HSPE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exocervical carcinoma
  • carcinoma of exocervix
sennetsu fever
  • sennetsu ehrlichiosis
leprosy
  • leprosy 2
carrion's disease
  • carrion disease
- elite association - COSMIC cancer census association via MalaCards
Search HSPE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPE1

Genetic Association Database (GAD)
HSPE1
Human Genome Epidemiology (HuGE) Navigator
HSPE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPE1
genes like me logo Genes that share disorders with HSPE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPE1 Gene

Publications for HSPE1 Gene

  1. Identification and cloning of human chaperonin 10 homologue. (PMID: 7914093) Monzini N. … Modena D. (Biochim. Biophys. Acta 1994) 2 3 4 22 64
  2. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. (PMID: 12483302) Hansen J.J. … Gregersen N. (Hum. Genet. 2003) 3 4 22 64
  3. Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10. (PMID: 7698325) Legname G. … Modena D. (FEBS Lett. 1995) 2 3 22 64
  4. The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. (PMID: 7912672) Cavanagh A.C. … Morton H. (Eur. J. Biochem. 1994) 3 4 22 64
  5. Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10. (PMID: 7916212) Chen J.J. … Androphy E.J. (Biochim. Biophys. Acta 1994) 3 4 22 64

Products for HSPE1 Gene

  • Cloud-Clone Corp. Antibodies for HSPE1
  • Cloud-Clone Corp. Proteins for HSPE1
  • Cloud-Clone Corp Assay Kits for HSPE1

Sources for HSPE1 Gene

Content
Loading form....