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HSPE1 Gene

protein-coding   GIFtS: 58
GCID: GC02P198328

Heat Shock 10kDa Protein 1

(Previous name: heat shock 10kD protein 1 (chaperonin 10))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 10kDa Protein 11 2     EPF2 3
Chaperonin 101 2 3     HSP102 5
Heat Shock 10kD Protein 1 (Chaperonin 10)1 2     10 KDa Heat Shock Protein, Mitochondrial2
Early-Pregnancy Factor2 3     GROES2
10 KDa Chaperonin2 3     Hsp103
CPN102 3     

External Ids:    HGNC: 52691   Entrez Gene: 33362   Ensembl: ENSG000001155417   OMIM: 6001415   UniProtKB: P616043   

Export aliases for HSPE1 gene to outside databases

Previous GC identifers: GC02P196563 GC02P197078 GC02P198567 GC02P198190 GC02P198073 GC02P190217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPE1 Gene:
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a
heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer
which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged
in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this
locus and the neighboring locus MOBKL3.(provided by RefSeq, Feb 2011)

GeneCards Summary for HSPE1 Gene:
HSPE1 (heat shock 10kDa protein 1) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and chaperone binding.

UniProtKB/Swiss-Prot: CH10_HUMAN, P61604
Function: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60.
Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter

Gene Wiki entry for HSPE1 (GroES) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPE1 gene promoter:
         c-Fos   p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPE1 promoter sequence
   Search Chromatin IP Primers for HSPE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

HSPE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPE1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P198328:  view genomic region     (about GC identifiers)

Start:
198,364,718 bp from pter      End:
198,368,187 bp from pter
Size:
3,470 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CH10_HUMAN, P61604 (See protein sequence)
Recommended Name: 10 kDa heat shock protein, mitochondrial  
Size: 102 amino acids; 10932 Da
Subunit: Homohexamer
Mass spectrometry: Mass=10843.5; Mass_error=0.2; Method=Electrospray; Range=2-102; Source=PubMed:7912672;
Secondary accessions: O95421 Q04984 Q53X54 Q9UDH0

Explore the universe of human proteins at neXtProt for HSPE1: NX_P61604

Explore proteomics data for HSPE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys28, Lys40, Lys86
  • Modification sites at PhosphoSitePlus

  • See HSPE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002148.1  
    ENSEMBL proteins: 
     ENSP00000233893   ENSP00000387101   ENSP00000386447  

    HSPE1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HSPE1 (HSP10/EPF)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HSPE1
    OriGene Protein Over-expression Lysate for HSPE1
    OriGene MassSpec for HSPE1
    OriGene Custom Protein Services for HSPE1
    GenScript Custom Purified and Recombinant Proteins Services for HSPE1
    Novus Biologicals HSPE1 Proteins
    Novus Biologicals HSPE1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPE1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSPE1 

    HSPE1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HSPE1 (HSP10/EPF)
    OriGene Antibodies for HSPE1
    OriGene Custom Antibody Services for HSPE1
    Novus Biologicals HSPE1 Antibodies
    Abcam antibodies for HSPE1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HSPE1
    LSBio Antibodies in human, mouse, rat for HSPE1

    HSPE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSPE1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for HSPE1 (HSP10/EPF)
    GenScript Custom Assay Services for HSPE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSPE1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    3 InterPro protein domains:
     IPR020818 Chaperonin_Cpn10
     IPR011032 GroES-like
     IPR018369 Chaprnonin_Cpn10_CS

    Graphical View of Domain Structure for InterPro Entry P61604

    ProtoNet protein and cluster: P61604

    UniProtKB/Swiss-Prot: CH10_HUMAN, P61604
    Similarity: Belongs to the GroES chaperonin family


    Find genes that share domains with HSPE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CH10_HUMAN, P61604
    Function: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60.
    Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
    Induction: By stress

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18319262
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding NAS12483302
    GO:0051087chaperone binding ISS--
         
    Find genes that share ontologies with HSPE1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HSPE1:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPE1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPE1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HSPE1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HSPE1:
    hsa-miR-206 hsa-miR-3673 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidHSPE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPE1
    Predesigned siRNA for gene silencing in human, mouse, rat HSPE1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPE1

    Clone
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    OriGene clones in human, mouse for HSPE1 (see all 6)
    OriGene ORF clones in mouse, rat for HSPE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPE1 (NM_002157)
    Sino Biological Human cDNA Clone for HSPE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPE1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HSPE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPE1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CH10_HUMAN, P61604: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with HSPE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPE1: 
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPE1 (P616041, 2, 3 ENSP000002338934) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932, 3MINT-63939 I2D: score=4 
    C14orf1Q9UKR52, 3MINT-63946 I2D: score=4 
    SAT1P216732, 3MINT-63565 I2D: score=4 
    TLE1Q047242, 3MINT-63940 I2D: score=4 
    UNC119Q134322, 3MINT-63941 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process NAS10205158
    GO:0006950response to stress ----
    GO:0006986response to unfolded protein TAS7698325

    Find genes that share ontologies with HSPE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPE1 (CH10)

    Selected Novoseek inferred chemical compound relationships for HSPE1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amp-pnp 54.2 4 8943246 (1), 8095403 (1), 8618836 (1)
    8-azido-atp 52.4 4 7867782 (2), 7789507 (1)
    atp 51.8 63 8947033 (3), 8608602 (3), 15347650 (3), 9571049 (3) (see all 24)
    mgatp 46.1 7 1974461 (1), 7908292 (1), 7911087 (1), 7789507 (1)
    malate 43.9 2 9102459 (1), 16375456 (1)
    adp 43.6 24 15347650 (3), 7913554 (2), 8947033 (1), 8943246 (1) (see all 10)
    guanidine hydrochloride 37.1 5 18329043 (3), 11152122 (1)
    pyruvate 16.4 5 17552551 (2), 17523614 (1), 10748134 (1), 15822913 (1)
    glyceraldehyde 3-phosphate 16.4 2 10196153 (1)
    acyl-coa 8.51 1 8104486 (1)



    Find genes that share compounds with HSPE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPE1 gene: 
    NM_002157.2  

    Unigene Cluster for HSPE1:

    Heat shock 10kDa protein 1 (chaperonin 10)
    Hs.1197  [show with all ESTs]
    Unigene Representative Sequence: BU517060
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233893(uc002uul.3) ENST00000409729 ENST00000473395 ENST00000409468
    ENST00000495200 ENST00000465573 ENST00000463841
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSPE1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HSPE1:
    hsa-miR-206 hsa-miR-3673 hsa-miR-1 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidHSPE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSPE1
    Predesigned siRNA for gene silencing in human, mouse, rat HSPE1
    Clone
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    OriGene clones in human, mouse for HSPE1 (see all 6)
    OriGene ORF clones in mouse, rat for HSPE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPE1 (NM_002157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPE1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPE1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPE1
      QuantiTect SYBR Green Assays in human, mouse, rat HSPE1
      QuantiFast Probe-based Assays in human, mouse, rat HSPE1

    Additional mRNA sequence: 

    AK312104.1 BC023518.2 CR407688.1 U07550.1 X75821.1 

    Selected DOTS entries (see all 39):

    DT.100044974  DT.92461991  DT.100884127  DT.95277215  DT.121018706  DT.95260889  DT.121018720  DT.101986431 
    DT.418296  DT.453986  DT.121018595  DT.99943534  DT.92461973  DT.121018567  DT.97862287  DT.100044972 
    DT.100884136  DT.121018475  DT.121018742  DT.92433271  DT.100884133  DT.120745414  DT.121018518  DT.100884126 

    Selected AceView cDNA sequences (see all 780):

    AF093825 AW005438 AV711028 BQ771697 BU187061 BM790468 AI680103 BE782274 
    AI521722 BF001699 BE858359 BP377734 AA988899 AI355935 BM661622 BQ441820 
    AA715833 AA004221 AI049924 N91932 AA448319 AA962519 AI652875 AI571758 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HSPE1    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                          -                                       
    SP2:                          -                 -                     
    SP3:                          -                                       
    SP4:                                                                  


    ECgene alternative splicing isoforms for HSPE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAATTT
    HSPE1 Expression
    About this image


    HSPE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HSPE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1197
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPE1: 
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPE1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPE1
    QuantiTect SYBR Green Assays in human, mouse, rat HSPE1
    QuantiFast Probe-based Assays in human, mouse, rat HSPE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPE1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspe11 , 5 heat shock protein 1 (chaperonin 10)1, 5 90.52(n)1
    96.08(a)1
      1 (28.02 cM)5
    155281  NM_008303.41  NP_032329.11 
     550881325 
    chicken
    (Gallus gallus)
    Aves HSPE16
    heat shock 10kDa protein 1
    57(a)
    1 ↔ 1
    AADN03014133.1(579-1536)
    lizard
    (Anolis carolinensis)
    Reptilia HSPE16
    heat shock 10kDa protein 1
    90(a)
    1 ↔ 1
    GL343436.1(676964-685290)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480339982   -- 78.35(n)    48033998 
    zebrafish
    (Danio rerio)
    Actinopterygii hspe12 heat shock 10kD protein 1 (chaperonin 10) 71.01(n)   58041  AF273739.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112676
    CG99206
    --
    52(a)
    46(a)
    many → 1
    many → 1
    3L(13009150-13010003)
    3R(9923015-9923802)
    worm
    (Caenorhabditis elegans)
    Secernentea Y22D7AL.101 , 3 Y22D7AL.101 62(a)3
    60.94(n)1
    62.63(a)1
      III(1689194-1690741)3
    1753151  NM_065027.61  NP_497428.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSP10(YOR020C)4
    HSP101
    Mitochondrial matrix co-chaperonin that inhibits the more4
    HSP101
    50(n)1
    45.83(a)1
      15(370844-370524)4
    8541851, 4  NP_014663.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CPN101 CPN10 53.62(n)
    53.26(a)
      838063  NM_101367.2  NP_563961.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06417001 Os07g0641700 52.98(n)
    50.53(a)
      4344071  NM_001066966.1  NP_001060431.1 


    ENSEMBL Gene Tree for HSPE1 (if available)
    TreeFam Gene Tree for HSPE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPE1 gene
    2 SIMAP similar genes for HSPE1 using alignment to 3 protein entries:     CH10_HUMAN (see all proteins):
    EPFP1    HSPE1-MOB4

    Find genes that share paralogs with HSPE1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HSPE1 (see all 28)
    PGOHUM00000238813 PGOHUM00000242499 PGOHUM00000239568 PGOHUM00000239670 PGOHUM00000239956


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HSPE1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600141    OMIM disorders: --


    Find genes that share disorders with HSPE1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSPE1 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 56.2 39 8608635 (2), 15059967 (2), 11810192 (2), 17348040 (2) (see all 27)
    abortion threatened 55.8 1 8329108 (1)
    abortion missed 44.5 1 8150373 (1)
    tuberculosis 43.1 36 12837802 (4), 9536120 (2), 11807250 (2), 7592820 (2) (see all 18)
    miscarriage recurrent 41.9 3 7959861 (2), 1720719 (1)
    endometrial cancer 21.1 2 17523614 (1), 16808467 (1)
    multiple sclerosis 15.4 8 19039022 (2), 9893026 (1), 18465663 (1)
    choriocarcinoma 12.7 1 8390229 (1)
    mimicry 10.3 1 7779079 (1)
    metastasis 3.4 4 16253146 (4)

    Genetic Association Database (GAD): HSPE1
    Human Genome Epidemiology (HuGE) Navigator: HSPE1 (2 documents)

    Export disorders for HSPE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPE1 gene, integrated from 10 sources (see all 226):
    (articles sorted by number of sources associating them with HSPE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of human chaperonin 10 homologue. (PubMed id 7914093)1, 2, 3, 9 Monzini N.... Modena D. (Biochim. Biophys. Acta 1994)
    2. The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10. (PubMed id 7912672)1, 2, 9 Cavanagh A.C. and Morton H. (Eur. J. Biochem. 1994)
    3. Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10. (PubMed id 7698325)1, 3, 9 Legname G....Modena D. (FEBS Lett. 1995)
    4. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. (PubMed id 12483302)1, 2, 9 Hansen J.J.... Gregersen N. (Hum. Genet. 2003)
    5. Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10. (PubMed id 7916212)1, 2, 9 Chen J.J.... Androphy E.J. (Biochim. Biophys. Acta 1994)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma. (PubMed id 17419711)1, 4 Ralph S....Jayson G.C. (Cancer Sci. 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family. (PubMed id 10763410)1, 2 Summers K.M.... Cavanagh A.C. (Somat. Cell Mol. Genet. 1998)
    10. Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence. (PubMed id 18329043)1, 9 Yagi H....Kawata Y. (J. Mol. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3336 HGNC: 5269 AceView: HSPE1andPREI3 Ensembl:ENSG00000115541 euGenes: HUgn3336
    ECgene: HSPE1 H-InvDB: HSPE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPE1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPE1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPE1 gene:
    Search GeneIP for patents involving HSPE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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