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HSP90AB1 Gene

protein-coding GIFtS: 62

GC06P044324

heat shock protein 90kDa alpha (cytosolic), class B member 1
(Previous names: heat shock 90kD protein 1, beta, heat shock 90kDa protein 1, beta )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HSPC2, HSPCB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
D6S182 ^²
FLJ26984 ^²
HSP90-BETA ^²
HSP90B ^², ³, ⁵
HSPC2 ^², ³, ⁵
HSPCB ^², ³, ⁵
OTTHUMP00000016517 ^²
OTTHUMP00000016518 ^²
OTTHUMP00000016519 ^²
OTTHUMP00000039869 ^²

Descriptions
HSP 84 ^³
HSP 90 ^³
heat shock 90kD protein 1, beta ^¹, ²
heat shock 90kDa protein 1, beta ^¹, ²
heat shock protein 90kDa alpha (cytosolic), class B member 1 ^²
heat shock protein beta ^²

External Ids
HGNC: 5258¹
Entrez Gene: 3326²
UniProtKB: P08238³
Ensembl: ENSG00000096384⁷

Search outside databases for aliases for HSP90AB1 gene

Previous GC identifer: GC06P044323

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HSP90AB1:

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal

transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins

normally associate with other cochaperones and play important roles in folding newly synthesized

proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic

HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other

HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1;

MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]

UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238

Function: Molecular chaperone. Has ATPase activity

Gene Wiki entry for HSP90AB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HSP90AB1 gene

Entrez Gene cytogenetic band: 6p12 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p12

HSP90AB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P044324: (about GC identifiers)

Start:	44,322,802 bp from pter
End:	44,329,598 bp from pter
Size:	6,797 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238 (See protein sequence)

Recommended Name: Heat shock protein HSP 90-beta

Size: 724 amino acids; 83264 Da

Subunit: Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to

UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

Sequence caution: Sequence=CAB66478.1; Type=Frameshift; Positions=709;

PDB structure from and Proteopedia :

1QZ2 (3D)

1UYM (3D)

Secondary accessions: Q5T9W7 Q9NQW0 Q9NTK6

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_031381.2

ENSEMBL proteins:

ENSP00000360709 ENSP00000325875 ENSP00000360609 ENSP00000360620 ENSP00000360611 ENSP00000360617

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hsp90 beta, Hsp90)
	Human Recombinant Proteins from Abnova (HSP90AB1)

OriGene Purified Recombinant Human Protein: HSP90AB1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	NAS	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for HSP90AB1:

	Invitrogen Antibodies for HSP90AB1
	Millipore Mono- and Polyclonal Antibodies for the study of HSP90AB1
	Sigma-Aldrich Antibody Arrays and Antibodies for HSP90AB1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for HSP90AB1 (HSP90beta)
	Antibodies from Abcam (Hsp90 beta, Hsp90), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HSP90AB1)
	Novus Biologicals Antibodies for HSP90AB1

Assays for HSP90AB1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08238

ProtoNet protein and cluster: P08238

2 Blocks protein families:

IPB001404 Heat shock protein Hsp90

IPB003594 ATP-binding region

UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238

Similarity: Belongs to the heat shock protein 90 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSP90AB1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007355

Applied Biosystems Silencer® siRNAs for HSP90AB1

Sigma-Aldrich siRNA and siRNA Panels for HSP90AB1

Sigma-Aldrich shRNA Panels and shRNA for HSP90AB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HSP90AB1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_007355
Myc/DDK tagged cDNA clone in CMV expression vector: NM_007355
untagged cDNA clone in CMV expression vector: NM_007355

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007355

UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238

Function: Molecular chaperone. Has ATPase activity

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hsp90ab1):

cellular

embryogenesis

lethality-prenatal/perinatal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0030235	nitric-oxide synthase regulator activity	ISS	--
GO:0030911	TPR domain binding	ISS	--
GO:0051082	unfolded protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for HSP90AB1 (Your Favorite Gene powered by Ingenuity) (see all 11 )

Aryl Hydrocarbon Receptor Signaling
Hypoxia Signaling in the Cardiovascular System
PPAR&alpha
Mitotic Roles of Polo-Like Kinase
PI3K/AKT Signaling

GeneDecks HSP90AB1 for the pathways selected above

About GeneDecksing

5/370 Interacting proteins for HSP90AB1 (P08238^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 370 )
Interactant Interaction Details
GeneCard External ID(s)
CHEK1 O14757¹ EBI-352572, EBI-974488
RAF1 P04049¹ EBI-352572, EBI-365996
DICER1 Q9UPY3² MINT-6489217 MINT-6488488 MINT-6488791
EEF1A1 P68104² MINT-6489217 MINT-6488488 MINT-6488791
EEF1AL7 P68104² MINT-6489217 MINT-6488488 MINT-6488791
About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006986 response to unfolded protein NAS 2768249
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 16280321
GO:0045429 positive regulation of nitric oxide biosynthetic process ISS --
GO:0060334 regulation of interferon-gamma-mediated signaling pathway IMP 16280321
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HSP90AB1

Browse Small Molecules at Sigma-Aldrich

Compounds for HSP90AB1 available from Tocris Bioscience

Compound	Action	CAS number
CCT 018159	Hsp90 inhibitor	[171009-07-7]
17-AAG	Selective Hsp90 inhibitor	[75747-14-7]
Macbecin I	Hsp90 inhibitor	[73341-72-7]
Gedunin	Hsp90 inhibitor; anticancer and antimalarial activity	[2753-30-2]
Radicicol	Hsp90 inhibitor. Antifungal antibiotic	[12772-57-5]

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7 Novoseek chemical compound relationships for HSP90AB1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
17-(allylamino)-17-demethoxygeldanamycin	68.04	1	17409432 (1)
steroid	32.15	4	1537818 (2), 2365084 (1)
estradiol	6.20	2	2365084 (1), 1491008 (1)
atp	0.00	1	14578462 (1)
polyacrylamide	0.00	1	9480920 (1)
oligonucleotide	0.00	8	8991187 (3)
progesterone	0.00	1	1312348 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSP90AB1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_007355

Sigma-Aldrich siRNA and siRNA Panels for HSP90AB1

Sigma-Aldrich shRNA Panels and shRNA for HSP90AB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007355

REFSEQ mRNAs for HSP90AB1 gene:

NM_007355.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007355

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_007355
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_007355
                                 untagged cDNA clone in CMV expression vector: NM_007355

Additional cDNA sequence:

AF275719.1 AK025370.1 AK130494.1 AK290734.1 AK294643.1 AK297367.1 AK312255.1 AL136543.1

AY359878.1 BC004928.1 BC007327.2 BC009206.2 BC012807.2 BC014485.1 BC016753.2 BC068474.1

BX649079.1 CR605481.1 CR612013.1 CR613983.1 CR618851.1 D28342.1 M16660.1

24/167 DOTS entries (see all 167 ):

DT.95313805 DT.92408441 DT.92470997 DT.121336150 DT.100725038 DT.92326561 DT.100725015 DT.91902593

DT.92411584 DT.121336080 DT.95139876 DT.121336390 DT.121336180 DT.100652561 DT.121336358 DT.100725069

DT.121336274 DT.100804704 DT.100725071 DT.97869713 DT.91657672 DT.100724999 DT.100725012 DT.121336112

24/219 AceView cDNA sequences (see all 219 ):

AW963867 T51115 AA487401 AA487283 AA075646 T59827 BI494859 AA075645

BM014574 H50320 T59996 AA101959 T51023 T59691 CA398011 AI094312

AI874069 AA211753 AA284704 AW675427 AA287134 AW439011 BM875458 BQ316345

highest scoring ESTs for HSP90AB1:

M16660 AA034511 AA035563 AA039819 AA053002 AA074189 AA075646 AA076380 AA099618 AA126226

Unigene Cluster for HSP90AB1:

Heat shock protein 90kDa alpha (cytosolic), class B member 1

Hs.509736 [show with all ESTs]

Unigene Representative Sequence: AY359878

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 (see all 12 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·
SP1:																																							-
SP2:																																							-
SP3:																																							-
SP4:									-										-
SP5:																																	-		-

ExUns:	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for HSP90AB1

6 Ensembl transcripts including schematic representations:

ENST00000371646 ENST00000353801 ENST00000371554 ENST00000371565 ENST00000371556 ENST00000371562

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HSP90AB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HSP90AB1

¹ / ² / ³

7 probe-sets matching HSP90AB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33984_at²^{, 3}	U95-A	3	1.00	0.73	0.96	1.03	M16660	1.00	1.00	1.00	1
1161_at²^{, 3}	U95-A	7	1.00	0.52	0.98	0.97	J04988	0.20	1.00	0.72	1
200064_at²^{, 3}	U133-B	4	1.00	0.70	--	--	AF275719	0.80	1.00	0.91	1
214359_s_at²^{, 3}	U133-A	4	1.00	0.64	--	--	AI218219	0.80	1.00	0.91	1
200064_at²	U133Plus2	4	1.00	0.70	--	--	--	--	--	--	--
214359_s_at²	U133Plus2	4	1.00	0.64	--	--	--	--	--	--	--
1557910_at²	U133Plus2	6	1.00	0.39	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.509736

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSP90AB1 gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC737497¹	--	similar to heat shock protein 90	99.54(n) 99.86(a)	737497 XM_001137889.1 XP_001137889.1
cow (Bos taurus)	HSP90AB1¹	--	heat shock 90kDa protein 1, beta	90.84(n) 99.59(a)	767874 XM_001253264.1 XP_001253265.1
rat (Rattus norvegicus)	Hsp90ab1¹	--	heat shock protein 90kDa alpha (cytosolic), class B more	89(n) 97.93(a)	301252 NM_001004082.2 NP_001004082.2
mouse (Mus musculus)	Hsp90ab1^{1, 5}	17 (15.00 cM)⁵	heat shock protein 90 alpha (cytosolic), class B member more^{1, 5}	89.69(n)¹ 99.59(a)¹	15516¹ NM_008302.3¹ NP_032328.2¹ AA105022⁵ AF465639⁵ (see all 47)
chicken (Gallus gallus)	HSPCB¹	--	heat shock 90kDa protein 1, beta	81.68(n) 94.89(a)	396188 NM_206959.1 NP_996842.1

About this table Species with no ortholog for HSP90AB1

ENSEMBL Gene Tree for HSP90AB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HSP90AB1 gene

HSP90AB3P² HSP90AA5P² HSP90AB2P² HSP90AA6P² HSP90AA4P² HSP90AB4P² HSP90AA2²

Pseudogenes

4 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/120 NCBI SNPs in HSP90AB1 are shown (see all 120 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 114)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3757283^1,2	A,C,F,H	44322395(+)	`TAGGAA/CGAAGA`	1	--	ng5¹ trp³		4	EU EA WA	412
--	rs1570920^1,2	A,C,F,O	44322414(+)	`GGGAGC/GGGTGG`	1	--	ng5¹		3	MN NS	262
--	rs324131^1,2	A,C,F	44322671(-)	`AAAAAG/AGAGGG`	1	--	ng5¹ trp³		5	MN EA NS	1530
	rs10948128^1,2	A,C,F	44322069(+)	`GAGCGG/CGTCGC`	1	--	ng5¹ tfbs³		6	MN EA NS	1700
	rs476632^1,2	A,C,F	44322303(-)	`TCGCAG/AGAGTA`	1	--	ng5¹		10	NA MN EA NS	1726
	rs9472238^1,2	C,F	44322668(+)	`GCCCCC/ATCYTT`	1	--	ng5¹ trp³		4	MN EA NS	1346
	rs35074133^1,2	C,F	44322847(+)	`GGGACT/AGTCTG`	1	--	ut5¹		2	NS	94
	rs9462978^1,2	C,F	44322555(+)	`CAAATG/AAGCAC`	1	--	ng5¹		4	MN EA NS	1346
	rs3757280^1,2	C,F	44321438(+)	`GGGTGG/CGCCAG`	1	--	ng5¹		3	EA NS	1554
	rs35336968^1,2	F	44322571(+)	`ATCCCC/GGCTCT`	1	--	ng5¹		2	NS	94

About this table

HapMap Linkage Disequilibrium images for HSP90AB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 140572

10 Novoseek disease relationships for HSP90AB1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	77.61	50	1988296 (3), 14532285 (3), 8991187 (2), 12569668 (2) (see all 37)
laryngeal carcinoma	33.90	3	11717891 (2), 10920983 (1)
laryngeal cancer	28.97	1	10920983 (1)
lupus erythematosus systemic	24.91	2	11771959 (1), 8216691 (1)
bronchitis chronic	23.39	1	11775547 (1)
breast cancer	8.52	4	10638971 (1), 10376793 (1), 9364934 (1), 1312348 (1)
melanoma	0.00	1	7954339 (1)
cancer	0.00	8	11721455 (1), 18497978 (1), 8878452 (1), 12369295 (1)
carcinoma	0.00	4	18497978 (1), 8878452 (1)
asthma	0.00	1	11775547 (1)

About this table

Human Genome Epidemiology Navigator: HSP90AB1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/148 PubMed articles for HSP90AB1 gene (see all 148 ):

Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PubMed id 2768249)^{2, 3, 4} Rebbe N.F.... Hickman S. (1989)
The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)^{1, 2, 3} Chen B....Monteiro A. (2005)
A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta). (PubMed id 8180474)^{1, 3, 4} Takahashi I.... Hashimoto K. (1994)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Phosphoproteomic analysis of synaptosomes from human cerebral cortex. (PubMed id 15822905)^{3, 4} DeGiorgis J.A.... Dosemeci A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3326	HGNC: 5258	AceView: HSPCB.1	Ensembl:ENSG00000096384	euGenes: HUgn3326
ECgene: HSP90AB1	H-InvDB: HSP90AB1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HSP90AB1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HSP90AB1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HSP90AB1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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Antibodies & Assays for HSP90AB1 (HSP90beta)

	Recombinant Proteins (Hsp90 beta, Hsp90)
	Antibodies (Hsp90 beta, Hsp90)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for HSP90AB1

	Drugs for HSP90AB1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HSP90AB1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
HSP90AB1 Gene at Home site.
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HSP90AB1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for HSP90AB1

Summaries
for HSP90AB1

Genomic Location
for HSP90AB1

Proteins
for HSP90AB1

Protein Domains/
Families
for HSP90AB1

Gene Function
for HSP90AB1

Pathways & Interactions
for HSP90AB1

Drugs & Compounds
for HSP90AB1

Transcripts
for HSP90AB1

Expression
for HSP90AB1

Orthologs
for HSP90AB1

Paralogs
for HSP90AB1

SNPs/Variants
for HSP90AB1

Disorders & Mutations
for HSP90AB1

Medical News
for HSP90AB1

Publications
for HSP90AB1

Search for HSP90AB1

Genome Databases showing HSP90AB1

Other Databases showing HSP90AB1

Specialized Databases showing HSP90AB1

Licensable Technologies
for HSP90AB1

Services
for HSP90AB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HSP90AB1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor HSP90AB1

Summariesfor HSP90AB1

Genomic Locationfor HSP90AB1

Proteinsfor HSP90AB1

Protein Domains/Familiesfor HSP90AB1

Gene Functionfor HSP90AB1

Pathways & Interactionsfor HSP90AB1

Drugs & Compoundsfor HSP90AB1

Transcriptsfor HSP90AB1

Expression for HSP90AB1

Orthologsfor HSP90AB1

Paralogsfor HSP90AB1

SNPs/Variantsfor HSP90AB1

Disorders & Mutationsfor HSP90AB1

Medical Newsfor HSP90AB1

Publicationsfor HSP90AB1

Search for HSP90AB1

Genome Databases showing HSP90AB1

Other Databases showing HSP90AB1

Specialized Databases showing HSP90AB1

Licensable Technologiesfor HSP90AB1

Servicesfor HSP90AB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HSP90AB1

Summaries
for HSP90AB1

Genomic Location
for HSP90AB1

Proteins
for HSP90AB1

Protein Domains/
Families
for HSP90AB1

Gene Function
for HSP90AB1

Pathways & Interactions
for HSP90AB1

Drugs & Compounds
for HSP90AB1

Transcripts
for HSP90AB1

Expression
for HSP90AB1

Orthologs
for HSP90AB1

Paralogs
for HSP90AB1

SNPs/Variants
for HSP90AB1

Disorders & Mutations
for HSP90AB1

Medical News
for HSP90AB1

Publications
for HSP90AB1

Licensable Technologies
for HSP90AB1

Services
for HSP90AB1