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HSP90AA1 Gene

protein-coding GIFtS: 69

GC14M101619

heat shock protein 90kDa alpha (cytosolic), class A member 1
(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein 1, alpha )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HSPC1, HSPCA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ31884 ^¹, ²
HSP86 ^²
HSP89A ^², ⁵
HSP90A ^², ³, ⁵
HSP90N ^¹, ²
HSPC1 ^², ³, ⁵
HSPCA ^², ³, ⁵
HSPCAL1 ^²
HSPCAL4 ^², ⁵
HSPN ^²
Hsp89 ^¹, ²
Hsp90 ^¹, ²
LAP2 ^², ⁵

Descriptions
HSP 86 ^³
Renal carcinoma antigen NY-REN-38 ^³
heat shock 90kD protein 1, alpha ^¹, ²
heat shock 90kD protein 1, alpha-like 4 ^²
heat shock 90kD protein, alpha-like 4 ^²
heat shock 90kDa protein 1, alpha ^¹, ²
heat shock protein 90kDa alpha (cytosolic), class A member 1 ^²

External Ids
HGNC: 5253¹
Entrez Gene: 3320²
UniProtKB: P07900³
Ensembl: ENSG00000080824⁷

Search outside databases for aliases for HSP90AA1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HSP90AA1:

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal

transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins

normally associate with other cochaperones and play important roles in folding newly synthesized

proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic

HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other

HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1;

MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM]

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Function: Molecular chaperone. Has ATPase activity (By similarity)

Gene Wiki entry for HSP90AA1 (Heat_shock_protein_90kDa_alpha%2C_member_A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HSP90AA1 gene

Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M101619: (about GC identifiers)

Start:	101,616,828 bp from pter
End:	101,675,839 bp from pter
Size:	59,012 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)

Recommended Name: Heat shock protein HSP 90-alpha

Size: 732 amino acids; 84660 Da

Subunit: Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

PDB structures from and Proteopedia :

1BYQ (3D)

1OSF (3D)

1UY6 (3D)

1UY7 (3D)

1UY8 (3D)

1UY9 (3D)

1UYC (3D)

1UYD (3D)

1UYE (3D)

1UYF (3D)

1UYG (3D)

1UYH (3D)

1UYI (3D)

1UYK (3D)

1UYL (3D)

1YC1 (3D)

1YC3 (3D)

1YC4 (3D)

1YER (3D)

1YES (3D)

1YET (3D)

2BSM (3D)

2BT0 (3D)

2BUG (3D)

2BYH (3D)

2BYI (3D)

2BZ5 (3D)

2C2L (3D)

2CCS (3D)

2CCT (3D)

2CCU (3D)

2CDD (3D)

2FWY (3D)

2FWZ (3D)

2H55 (3D)

2JJC (3D)

2K5B (3D)

2QF6 (3D)

2QFO (3D)

2QG0 (3D)

2QG2 (3D)

2UWD (3D)

2VCI (3D)

2VCJ (3D)

3BM9 (3D)

3BMY (3D)

3D0B (3D)

3EKO (3D)

3EKR (3D)

3FT5 (3D)

Secondary accessions: Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5

Alternative splicing: 2 isoforms: P07900-1 P07900-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001017963.2 NP_005339.3

ENSEMBL proteins:

ENSP00000216281 ENSP00000335153

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hsp90, Hsp90 alpha)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: HSP90AA1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	NAS	12526792
GO:0042470	melanosome	IEA	--

About this table

Antibodies for HSP90AA1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
	Sigma-Aldrich Antibody Arrays and Antibodies for HSP90AA1
	R&D Systems Antibodies for HSP90AA1 (HSP90)
	Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90alpha)
	Antibodies from Abcam (Hsp90, Hsp90 alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HSP90AA1)
	Novus Biologicals Antibodies for HSP90AA1

Assays for HSP90AA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07900

ProtoNet protein and cluster: P07900

2 Blocks protein families:

IPB001404 Heat shock protein Hsp90

IPB003594 ATP-binding region

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Similarity: Belongs to the heat shock protein 90 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSP90AA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017963

Applied Biosystems Silencer® siRNAs for HSP90AA1

Sigma-Aldrich siRNA and siRNA Panels for HSP90AA1

Sigma-Aldrich shRNA Panels and shRNA for HSP90AA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017963
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017963
untagged cDNA clones in CMV expression vector (see all 3): AK056446

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001017963

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Function: Molecular chaperone. Has ATPase activity (By similarity)

1 MGI phenotypic allele for Hsp90aa1 (no phenotypes)

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	TAS	11470816
GO:0005524	ATP binding	TAS	11470816
GO:0030235	nitric-oxide synthase regulator activity	ISS	--
GO:0030911	TPR domain binding	TAS	12526792
GO:0042803	protein homodimerization activity	TAS	11470816

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for HSP90AA1 (Your Favorite Gene powered by Ingenuity) (see all 15 )

Glucocorticoid Receptor Signaling
Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System
Aryl Hydrocarbon Receptor Signaling
PI3K/AKT Signaling

GeneDecks HSP90AA1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HSP90AA1

5/298 Interacting proteins for HSP90AA1 (P07900^{1, 2} ENSP00000335153³) via UniProtKB, MINT, and/or STRING (see all 298 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FKBP8	Q14318², ENSP00000222308³	MINT-3378966 MINT-3378905 MINT-3378991 MINT-3378882 MINT-3378859 MINT-3378925 STRING (score=.979)
CDC37	Q16543², ENSP00000222005³	MINT-6797194 MINT-6797182 MINT-6797216 MINT-6797232 STRING (score=.999)
CHUK	O15111², ENSP00000359424³	MINT-47953 MINT-48053 STRING (score=.986)
IKBKB	O14920², ENSP00000339151³	MINT-48091 MINT-47957 STRING (score=.986)
IKBKG	Q9Y6K9², ENSP00000358622³	MINT-47968 MINT-48190 STRING (score=.97)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006839	mitochondrial transport	TAS	12526792
GO:0006986	response to unfolded protein	NAS	2527334
GO:0007165	signal transduction	NAS	11470816
GO:0034619	cellular chaperone-mediated protein complex assembly	IDA	15644312
GO:0042026	protein refolding	TAS	9660753

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for HSP90AA1

Sigma-Aldrich Small Molecules for HSP90AA1:

Antagonist

Compounds for HSP90AA1 available from Tocris Bioscience

Compound	Action	CAS number
CCT 018159	Hsp90 inhibitor	[171009-07-7]
17-AAG	Selective Hsp90 inhibitor	[75747-14-7]
Macbecin I	Hsp90 inhibitor	[73341-72-7]
Gedunin	Hsp90 inhibitor; anticancer and antimalarial activity	[2753-30-2]
Radicicol	Hsp90 inhibitor. Antifungal antibiotic	[12772-57-5]

About this table

10/31 Novoseek chemical compound relationships for HSP90AA1 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
17-(allylamino)-17-demethoxygeldanamycin	96.84	314	15841378 (5), 16634649 (4), 15057143 (3), 17090671 (3) (see all 99)
17-amino-17-demethoxygeldanamycin	83.63	4	14571691 (1), 16854066 (1), 9890555 (1)
17-dmag	78.65	6	15338192 (4), 17088927 (1), 12725864 (1)
lbh-589	75.42	11	15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 5)
molybdate	72.14	37	10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
steroid	68.04	195	8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
5-methoxy-1,2-dimethyl-3-(4-nitrophenoxymethyl)indole-4,7-dione	64.17	1	16825487 (1)
atp	61.47	285	11441008 (7), 16741950 (6), 15671027 (6), 11054293 (6) (see all 99)
dimethyl pimelimidate	59.15	2	1313229 (1)
sodium molybdate	53.65	2	9115298 (1), 10617682 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSP90AA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017963

Sigma-Aldrich siRNA and siRNA Panels for HSP90AA1

Sigma-Aldrich shRNA Panels and shRNA for HSP90AA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001017963 NM_005348

REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts):

NM_001017963.2 NM_005348.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001017963 NM_005348

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001017963
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001017963
                                 untagged cDNA clones in CMV expression vector (see all 3): AK056446

Additional cDNA sequence:

AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1

AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2

BX247955.1 BX248761.1 CR589993.1 CR593964.1 CR594716.1 CR596117.1 CR599002.1 CR604052.1

CR605488.1 CR607053.1 CR610614.1 CR611827.1 CR611873.1 CR613014.1 CR615580.1 CR621835.1

CR623660.1 X07270.1 X15183.1

24/170 DOTS entries (see all 170 ):

DT.100849252 DT.91781494 DT.100658316 DT.91845523 DT.100730414 DT.100730410 DT.100730420 DT.100801571

DT.95129185 DT.98131982 DT.100680135 DT.100730476 DT.100860129 DT.92061474 DT.100730481 DT.100857433

DT.100730448 DT.120782168 DT.100846879 DT.97848044 DT.100662911 DT.95378226 DT.100730426 DT.97848122

24/2627 AceView cDNA sequences (see all 2627 ):

BP363688 BM763718 BQ688439 AA586565 BQ446823 CB132694 BP350083 AI061261

BU581404 BP349697 AA586919 BI861290 AL043533 BP334337 BM557588 BE501582

AA312098 BE889713 BM801487 BP429471 AA375568 AA937732 BQ427532 AA318966

highest scoring ESTs for HSP90AA1:

AI878849 AK056446 BX248761 X15183 AA026444 AA076019 AA093560 AA130815 AA132815 AA134010

Unigene Cluster for HSP90AA1:

Heat shock protein 90kDa alpha (cytosolic), class A member 1

Hs.525600 [show with all ESTs]

Unigene Representative Sequence: NM_001017963

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^
SP1:									-						-		-
SP2:																	-
SP3:																	-
SP4:
SP5:

ExUns:	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for HSP90AA1

2 Ensembl transcripts including schematic representations:

ENST00000216281 ENST00000334701

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HSP90AA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HSP90AA1

¹ / ² / ³

9 probe-sets matching HSP90AA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32316_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X15183	0.80	1.00	0.91	1
214328_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210211_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF028832	0.40	1.00	0.76	1
211968_s_at²^{, 3}	U133-A	5	1.00	0.65	--	--	AI962933	0.40	1.00	0.76	1
211969_at²^{, 3}	U133-A	6	1.00	0.39	--	--	BG420237	0.60	0.75	0.68	1
214328_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210211_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211968_s_at²	U133Plus2	5	1.00	0.65	--	--	--	--	--	--	--
211969_at²	U133Plus2	6	1.00	0.39	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCATACAGAC

SOURCE GeneReport for Unigene cluster: Hs.525600

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSP90AA1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC480438¹	--	similar to heat shock protein 1, alpha	88.11(n) 99.19(a)	480438 XM_537557.2 XP_537557.2
chimpanzee (Pan troglodytes)	HSP90AA1¹	--	heat shock protein 90kDa alpha (cytosolic), class A more	99.26(n) 99.3(a)	743883 XM_001160832.1 XP_001160832.1
cow (Bos taurus)	HSPCA¹	--	heat shock 90kD protein 1, alpha	89.16(n) 99.59(a)	281832 NM_001012670.1 NP_001012688.1
rat (Rattus norvegicus)	Hsp90aa1¹	--	heat shock protein 90, alpha (cytosolic), class A member more	91.07(n) 99.32(a)	299331 NM_175761.2 NP_786937.1
mouse (Mus musculus)	Hsp90aa1^{1, 5}	12 (48.00 cM)⁵	heat shock protein 90, alpha (cytosolic), class A member more^{1, 5}	90.3(n)¹ 99.18(a)¹	15519¹ NM_010480.4¹ NP_034610.1¹ AK004658⁵ AK077095⁵ (see all 61)

About this table Species with no ortholog for HSP90AA1

ENSEMBL Gene Tree for HSP90AA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HSP90AA1 gene

HSP90AB3P² HSP90AA5P² HSP90AB2P² HSP90AA6P² HSP90AB1² HSP90AA4P² HSP90AB4P²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/344 NCBI SNPs in HSP90AA1 are shown (see all 344 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8005905^1,2	A,C,F,H	101638120(+)	`CACCAA/TCAGAT`	1	M/L	mis¹ ese³		20		EA NA EU WA NS	1748
--	rs1058078^1,2	A,C,F,H	101617401(-)	`CTTTTT/CGAACT`	2	--	ut3¹		15		MN EU EA WA NS	1536
	rs1059629^1,2	C,F,H	101616858(-)	`CTGTGC/TTAAAT`	2	--	ut3¹		11		NA EU EA WA	894
	rs2298878^1,2	C,F,H	101617498(-)	`CAAGCC/TGGATG`	2	--	ut3¹ ese³		8		EA NA EU WA	2034
	rs8020653^1,2	C,F,H	101616390(+)	`CTAAAC/TGTGAT`	2	--	ng5¹		5		EA WA NS	322
	rs11847709^1,2	C,F,H	101616565(+)	`CTAACC/GAAGTT`	2	--	ng5¹		5		EU EA NS	346
--	rs10151188^1,2	F,H	101625253(+)	`tgatcC/Tgcccg`	2	--	ng3¹ int¹		1		EU	118
	rs3809386^1,2	A,C	101624544(-)	`AAAACC/GCCTGC`	2	--	int¹ ng3¹		0	--	--	--	--
	rs4906179^1,2	A,C	101624514(+)	`GGTCTC/TTAGGG`	2	--	ng3¹ int¹		0	--	--	--	--
--	rs11547531^1,2	C,F	101617355(-)	`AGTCCT/CCTAGA`	2	--	ut3¹ ese³		2		NS	94

About this table

HapMap Linkage Disequilibrium images for HSP90AA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 140571

10/92 Novoseek disease relationships for HSP90AA1 gene (see all 92 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	92.37	883	16452239 (5), 16218955 (4), 15347681 (3), 10946285 (3) (see all 99)
cancer	59.59	369	16842157 (6), 14624223 (6), 16610363 (5), 17266581 (5) (see all 99)
tumors	50.45	285	17409397 (5), 17968312 (5), 17671112 (4), 19229106 (4) (see all 99)
breast cancer	38.82	65	17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 34)
neurodegenerative diseases	37.55	12	19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
leukemia	32.83	39	14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 23)
myeloid leukemia chronic	30.46	3	10939589 (2), 15514006 (1)
colon cancer	27.35	17	18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 11)
prostate cancer	25.14	15	14571418 (3), 17221841 (2), 18726985 (1), 19147983 (1) (see all 9)
neurodegeneration	21.19	7	17185503 (1), 17536171 (1), 19090995 (1)

About this table

Human Gene Mutation Database: HSP90AA1
Human Genome Epidemiology Navigator: HSP90AA1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1342 PubMed articles for HSP90AA1 gene (see all 1342 ):

The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)^{1, 2, 3, 4} Chen B....Monteiro A. (2005)
Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)^{2, 3, 4} Hickey E.... Weber L.A. (1989)
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)^{1, 3, 4} Obermann W.M.... Hartl F.U. (1998)
Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)^{1, 3, 4} Young J.C.... Hartl F.U. (1998)
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. (PubMed id 9108479)^{1, 3, 4} Stebbins C.E....Pavletich N.P. (1997)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)^{3, 4} Baba M....Zbar B. (2006)
Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)^{3, 4} Beranova-Giorgianni S.... Giorgianni F. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Phosphoproteomic analysis of synaptosomes from human cerebral cortex. (PubMed id 15822905)^{3, 4} DeGiorgis J.A.... Dosemeci A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3320	HGNC: 5253	AceView: HSPCA	Ensembl:ENSG00000080824	euGenes: HUgn3320
ECgene: HSP90AA1	H-InvDB: HSP90AA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HSP90AA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HSP90AA1:

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Antibodies & Assays for HSP90AA1 (HSP90alpha)

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	Antibodies (Hsp90, Hsp90 alpha)

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Tocris compounds for HSP90AA1

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Antibodies for HSP90AA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HSP90AA1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for HSP90AA1

Summaries
for HSP90AA1

Genomic Location
for HSP90AA1

Proteins
for HSP90AA1

Protein Domains/
Families
for HSP90AA1

Gene Function
for HSP90AA1

Pathways & Interactions
for HSP90AA1

Drugs & Compounds
for HSP90AA1

Transcripts
for HSP90AA1

Expression
for HSP90AA1

Orthologs
for HSP90AA1

Paralogs
for HSP90AA1

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for HSP90AA1

Disorders & Mutations
for HSP90AA1

Medical News
for HSP90AA1

Publications
for HSP90AA1

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Genome Databases showing HSP90AA1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HSP90AA1 (Gene Symbol)
FLJ31884
HSP86
HSP89A
HSP90A
HSP90N
HSPC1
HSPCA
HSPCAL1
HSPCAL4
HSPN
Hsp89
Hsp90
LAP2
HSP 86
Renal carcinoma antigen NY-REN-38
heat shock 90kD protein 1, alpha
heat shock 90kD protein 1, alpha-like 4
heat shock 90kD protein, alpha-like 4
heat shock 90kDa protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1

HSP90AA1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor HSP90AA1

Summariesfor HSP90AA1

Genomic Locationfor HSP90AA1

Proteinsfor HSP90AA1

Protein Domains/Familiesfor HSP90AA1

Gene Functionfor HSP90AA1

Pathways & Interactionsfor HSP90AA1

Drugs & Compoundsfor HSP90AA1

Transcriptsfor HSP90AA1

Expression for HSP90AA1

Orthologsfor HSP90AA1

Paralogsfor HSP90AA1

SNPs/Variantsfor HSP90AA1

Disorders & Mutationsfor HSP90AA1

Medical Newsfor HSP90AA1

Publicationsfor HSP90AA1

Search for HSP90AA1

Genome Databases showing HSP90AA1

Other Databases showing HSP90AA1

Specialized Databases showing HSP90AA1

Licensable Technologiesfor HSP90AA1

Servicesfor HSP90AA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HSP90AA1

Summaries
for HSP90AA1

Genomic Location
for HSP90AA1

Proteins
for HSP90AA1

Protein Domains/
Families
for HSP90AA1

Gene Function
for HSP90AA1

Pathways & Interactions
for HSP90AA1

Drugs & Compounds
for HSP90AA1

Transcripts
for HSP90AA1

Expression
for HSP90AA1

Orthologs
for HSP90AA1

Paralogs
for HSP90AA1

SNPs/Variants
for HSP90AA1

Disorders & Mutations
for HSP90AA1

Medical News
for HSP90AA1

Publications
for HSP90AA1

Licensable Technologies
for HSP90AA1

Services
for HSP90AA1