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Aliases for HSPBP1 Gene

Aliases for HSPBP1 Gene

  • HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1 2 3
  • Heat Shock Protein-Binding Protein 1 3 4
  • Hsp70 Interacting Protein 2 3
  • Hsp70-Interacting Protein 1 4
  • Hsp70-Interacting Protein 2 4
  • Hsp70 Binding Protein 1 2
  • Hsp70-Binding Protein 2 4
  • HspBP1 4
  • HspBP2 4
  • HSPBP 4
  • FES1 3

External Ids for HSPBP1 Gene

Previous GeneCards Identifiers for HSPBP1 Gene

  • GC19M056638
  • GC19M056198
  • GC19M060449
  • GC19M060465
  • GC19M055773
  • GC19M052097

Summaries for HSPBP1 Gene

GeneCards Summary for HSPBP1 Gene

HSPBP1 (HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for HSPBP1 Gene

  • Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Wiki entry for HSPBP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBP1 Gene

Genomics for HSPBP1 Gene

Regulatory Elements for HSPBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPBP1 Gene

Chromosome:
19
Start:
55,262,222 bp from pter
End:
55,280,383 bp from pter
Size:
18,162 bases
Orientation:
Minus strand

Genomic View for HSPBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBP1 Gene

Proteins for HSPBP1 Gene

  • Protein details for HSPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL4-HPBP1_HUMAN
    Recommended name:
    Hsp70-binding protein 1
    Protein Accession:
    Q9NZL4
    Secondary Accessions:
    • B3KQP0
    • B4DG11
    • O95351
    • Q6ZNU5

    Protein attributes for HSPBP1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39474 Da
    Quaternary structure:
    • Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.

    Three dimensional structures from OCA and Proteopedia for HSPBP1 Gene

    Alternative splice isoforms for HSPBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPBP1 Gene

Proteomics data for HSPBP1 Gene at MOPED

Post-translational modifications for HSPBP1 Gene

  • Ubiquitination at Lys 97, Lys 210, and Lys 248
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HSPBP1 Gene

Domains & Families for HSPBP1 Gene

Protein Domains for HSPBP1 Gene

Suggested Antigen Peptide Sequences for HSPBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZL4

UniProtKB/Swiss-Prot:

HPBP1_HUMAN :
  • Contains 4 ARM repeats.
Similarity:
  • Contains 4 ARM repeats.
genes like me logo Genes that share domains with HSPBP1: view

No data available for Gene Families for HSPBP1 Gene

Function for HSPBP1 Gene

Molecular function for HSPBP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Ontology (GO) - Molecular Function for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity IBA --
GO:0004857 enzyme inhibitor activity TAS 9830037
GO:0005488 binding --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HSPBP1: view

Phenotypes for HSPBP1 Gene

GenomeRNAi human phenotypes for HSPBP1:
genes like me logo Genes that share phenotypes with HSPBP1: view

Animal Model Products

CRISPR Products

miRNA for HSPBP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPBP1 Gene

Localization for HSPBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPBP1 Gene COMPARTMENTS Subcellular localization image for HSPBP1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HSPBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPBP1 Gene

Pathways & Interactions for HSPBP1 Gene

genes like me logo Genes that share pathways with HSPBP1: view

Pathways by source for HSPBP1 Gene

Gene Ontology (GO) - Biological Process for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9830037
GO:0031398 positive regulation of protein ubiquitination IDA 16831871
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 16831871
GO:0043086 negative regulation of catalytic activity TAS 9830037
GO:0050790 regulation of catalytic activity IBA --
genes like me logo Genes that share ontologies with HSPBP1: view

No data available for SIGNOR curated interactions for HSPBP1 Gene

Drugs & Compounds for HSPBP1 Gene

No Compound Related Data Available

Transcripts for HSPBP1 Gene

Unigene Clusters for HSPBP1 Gene

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for HSPBP1 Gene

GeneLoc Exon Structure for
HSPBP1
ECgene alternative splicing isoforms for
HSPBP1

Expression for HSPBP1 Gene

mRNA expression in normal human tissues for HSPBP1 Gene

Protein differential expression in normal tissues from HIPED for HSPBP1 Gene

This gene is overexpressed in Bone (27.2) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPBP1 Gene



SOURCE GeneReport for Unigene cluster for HSPBP1 Gene Hs.53066

mRNA Expression by UniProt/SwissProt for HSPBP1 Gene

Q9NZL4-HPBP1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with HSPBP1: view

Protein tissue co-expression partners for HSPBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSPBP1 Gene

Orthologs for HSPBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPBP1 35
  • 89.17 (n)
  • 92.44 (a)
HSPBP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPBP1 35
  • 88.52 (n)
  • 93 (a)
HSPBP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspbp1 35
  • 86.46 (n)
  • 93.56 (a)
Hspbp1 16
Hspbp1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspbp1 35
  • 87.02 (n)
  • 93.84 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPBP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPBP1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPBP1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPBP1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPBP1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspbp1 35
  • 63.47 (n)
  • 66.77 (a)
Str.2669 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16057 35
zebrafish
(Danio rerio)
Actinopterygii hspbp1 35
  • 58.78 (n)
  • 56.47 (a)
idibd1110 35
hspbp1 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.342 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008392 35
  • 48.54 (n)
  • 31.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10973 35
  • 38.95 (n)
  • 28.49 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons Fes1A 35
  • 39.15 (n)
  • 26.55 (a)
rice
(Oryza sativa)
Liliopsida Os03g0822700 35
  • 41.94 (n)
  • 28.36 (a)
Species with no ortholog for HSPBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBP1 Gene

ENSEMBL:
Gene Tree for HSPBP1 (if available)
TreeFam:
Gene Tree for HSPBP1 (if available)

Paralogs for HSPBP1 Gene

No data available for Paralogs for HSPBP1 Gene

Variants for HSPBP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1071633 -- 55,262,396(-) CCGTT(C/T)TCTTG utr-variant-3-prime, reference, missense
rs1129953 -- 55,262,260(-) GAGCC(A/C)CTGGA utr-variant-3-prime
rs1129955 -- 55,262,394(-) GTTCT(C/T)TTGTC utr-variant-3-prime, reference, synonymous-codon
rs1140226 -- 55,262,426(-) ACCCC(A/C)CCTCC utr-variant-3-prime, reference, missense
rs1801568 -- 55,262,542(-) ACCTA(A/C)AAGGC utr-variant-3-prime, missense, reference

Structural Variations from Database of Genomic Variants (DGV) for HSPBP1 Gene

Variant ID Type Subtype PubMed ID
nsv912454 CNV Loss 21882294
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912458 CNV Loss 21882294
nsv912459 CNV Loss 21882294

Variation tolerance for HSPBP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPBP1 Gene

HapMap Linkage Disequilibrium report
HSPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBP1 Gene

Disorders for HSPBP1 Gene

Relevant External Links for HSPBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPBP1
genes like me logo Genes that share disorders with HSPBP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPBP1 Gene

Publications for HSPBP1 Gene

  1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PMID: 10786638) Guerriero V. Jr. … Raynes D.A. (Biochim. Biophys. Acta 2000) 2 23 67
  2. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PMID: 9830037) Raynes D.A. … Guerriero V. Jr. (J. Biol. Chem. 1998) 2 23 67
  3. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. (PMID: 17855353) Tanimura S. … Kohno M. (J. Biol. Chem. 2007) 23 67
  4. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PMID: 16677834) Gottwald E. … Guerriero V. (Cell Biol. Int. 2006) 23 67
  5. Development of a sensitive assay for the measurement of antibodies against heat shock protein binding protein 1 (HspBP1): increased levels of anti-HspBP1 IgG are prevalent in HIV infected subjects. (PMID: 15977250) Papp D. … Guerriero V. (J. Med. Virol. 2005) 23 67

Products for HSPBP1 Gene

Sources for HSPBP1 Gene

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