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HSPBP1 Gene

protein-coding   GIFtS: 56
GCID: GC19M055773

HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone...

  Search for HSPBP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 11 2     FES12
Hsp70 Binding Protein 11 2     Hsp70-Binding Protein 12
Hsp70 Interacting Protein1 2     hspBP22
Heat Shock Protein-Binding Protein 12 3     HSPBP3
Hsp70-Binding Protein 22 3     HspBP13
Hsp70-Interacting Protein 12 3     HspBP23
Hsp70-Interacting Protein 22 3     

External Ids:    HGNC: 249891   Entrez Gene: 236402   Ensembl: ENSG000001332657   OMIM: 6129395   UniProtKB: Q9NZL43   
ORGUL members:         

Export aliases for HSPBP1 gene to outside databases

Previous GC identifers: GC19M056638 GC19M056198 GC19M060449 GC19M060465 GC19M052097


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSPBP1 Gene:
HSPBP1 (HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1) is a protein-coding gene. GO annotations related to this gene include enzyme inhibitor activity.

UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and
interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted
degradation of immature CFTR

Gene Wiki entry for HSPBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPBP1 gene promoter:
         Spz1   MyoD   LUN-1   E47   Arnt   Roaz   C/EBPalpha   PPAR-gamma1   Cart-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPBP1 promoter sequence
   Search Chromatin IP Primers for HSPBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

HSPBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPBP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055773:  view genomic region     (about GC identifiers)

Start:
55,773,591 bp from pter      End:
55,791,751 bp from pter
Size:
18,161 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4 (See protein sequence)
Recommended Name: Hsp70-binding protein 1  
Size: 362 amino acids; 39474 Da
Subunit: Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A
and HSPBP1
2 PDB 3D structures from and Proteopedia for HSPBP1:
1XQR (3D)        1XQS (3D)    
Secondary accessions: B3KQP0 B4DG11 O95351 Q6ZNU5
Alternative splicing: 3 isoforms:  Q9NZL4-1   Q9NZL4-2   Q9NZL4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HSPBP1: NX_Q9NZL4

Explore proteomics data for HSPBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys210, Lys248
  • Modification sites at PhosphoSitePlus

  • See HSPBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123578.1  NP_036399.3  

    ENSEMBL proteins: 
     ENSP00000255631   ENSP00000398244   ENSP00000467574   ENSP00000466569   ENSP00000466749  
     ENSP00000465876   ENSP00000465690   ENSP00000468403   ENSP00000467926   ENSP00000365521  

    HSPBP1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HSPBP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HSPBP1
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    Novus Biologicals HSPBP1 Proteins
    Novus Biologicals HSPBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPBP1
    Cloud-Clone Corp. Proteins for HSPBP1

     
    Search eBioscience for Proteins for HSPBP1 

    HSPBP1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for HSPBP1

    HSPBP1 Assay Products:

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    Cloud-Clone Corp. ELISAs for HSPBP1
    Cloud-Clone Corp. CLIAs for HSPBP1
    Search eBioscience for ELISAs for HSPBP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NZL4

    ProtoNet protein and cluster: Q9NZL4

    UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
    Similarity: Contains 4 ARM repeats


    Find genes that share domains with HSPBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPBP1_HUMAN, Q9NZL4
    Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and
    interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted
    degradation of immature CFTR

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS9830037
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with HSPBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HSPBP1:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPBP1:
    hsa-mir-484 (MIRT042390), hsa-mir-7-5p (MIRT025683), hsa-mir-16-5p (MIRT031614), hsa-mir-92a-3p (MIRT049498), hsa-mir-125b-5p (MIRT046019)

    Block miRNA regulation of human, mouse, rat HSPBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPBP1 (see all 10):
    hsa-miR-30c-2* hsa-miR-1321 hsa-miR-3138 hsa-miR-650 hsa-miR-661 hsa-miR-23b* hsa-miR-30c-1* hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidHSPBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPBP1
    Predesigned siRNA for gene silencing in human, mouse, rat HSPBP1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HSPBP1 (NM_001130106)
    Sino Biological Human cDNA Clone for HSPBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBP1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    vacuole1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with HSPBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for HSPBP1
        Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Regulation of degradation of wt-CFTR



    1 Kegg Pathway  (Kegg details for HSPBP1):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSPBP1
    Interactions:

        GeneGlobe Interaction Network for HSPBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPBP1 (Q9NZL41, 2, 3 ENSP000002556314) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-2871494 I2D: score=7 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000215328P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000224501P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000231555P081072, 3MINT-2871494 I2D: score=7 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS9830037
    GO:0031398positive regulation of protein ubiquitination IDA16831871
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA16831871
    GO:0043086negative regulation of catalytic activity TAS9830037

    Find genes that share ontologies with HSPBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSPBP1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Browse Tocris compounds for HSPBP1 (HPBP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPBP1 gene (2 alternative transcripts): 
    NM_001130106.1  NM_012267.4  

    Unigene Cluster for HSPBP1:

    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
    Hs.53066  [show with all ESTs]
    Unigene Representative Sequence: NM_012267
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255631(uc002qjx.3 uc002qkd.3) ENST00000433386(uc002qkc.3)
    ENST00000587922 ENST00000585927 ENST00000587959 ENST00000593263 ENST00000585698
    ENST00000588971 ENST00000587551 ENST00000376343
    miRNA
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    Block miRNA regulation of human, mouse, rat HSPBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPBP1 (see all 10):
    hsa-miR-30c-2* hsa-miR-1321 hsa-miR-3138 hsa-miR-650 hsa-miR-661 hsa-miR-23b* hsa-miR-30c-1* hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidHSPBP1 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for HSPBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSPBP1 (NM_001130106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBP1
    Primer
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    OriGene qPCR primer pairs and template standards for HSPBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPBP1
      QuantiTect SYBR Green Assays in human, mouse, rat HSPBP1
      QuantiFast Probe-based Assays in human, mouse, rat HSPBP1

    Additional mRNA sequence: 

    AB020592.1 AF093420.1 AF187859.1 AF217996.1 AK075293.1 AK129755.1 AK130636.1 AK130781.1 
    AK294358.1 BC001236.1 BC002373.2 CR457118.1 

    22 DOTS entries:

    DT.75165530  DT.101978247  DT.100879806  DT.100879808  DT.100879813  DT.121426668  DT.40131409  DT.100030991 
    DT.100696204  DT.100879812  DT.100692913  DT.100879822  DT.100879823  DT.121426634  DT.100030986  DT.100728600 
    DT.100879809  DT.100879825  DT.121426625  DT.92448196  DT.92448199  DT.95164315 

    Selected AceView cDNA sequences (see all 459):

    AB020592 BU180881 BG387924 CR600655 BM819046 CR606354 CR625784 CR620770 
    BI118072 BM714534 CR615864 H84150 CR608022 CR619038 BQ934926 AI183652 
    BM971350 CB850695 CR615309 BM984258 AI339762 CA417869 CR604616 BU160496 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                                                                  
    SP2:              -                 -                                                                                 
    SP3:              -                 -                                                                                 
    SP4:                                                                                                                  
    SP5:                                                        -                                                         


    ECgene alternative splicing isoforms for HSPBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCACTCT
    HSPBP1 Expression
    About this image

    HSPBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.53066

    UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for HSPBP1
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    QuantiTect SYBR Green Assays in human, mouse, rat HSPBP1
    QuantiFast Probe-based Assays in human, mouse, rat HSPBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPBP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspbp11 , 5 HSPA (heat shock 70kDa) binding protein, cytoplasmic more1, 5 86.46(n)1
    93.56(a)1
      7 (2.69 cM)5
    662451  NM_024172.31  NP_077134.11 
     46605215 
    chicken
    (Gallus gallus)
    Aves HSPBP16
    HSPA (heat shock 70kDa) binding protein, cytoplasm...
    46(a)
    1 ↔ 1
    AADN03025554.1(21-2670)
    lizard
    (Anolis carolinensis)
    Reptilia HSPBP16
    HSPA (heat shock 70kDa) binding protein, cytoplasm...
    69(a)
    1 ↔ 1
    GL343355.1(1113982-1132574)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160572 Xenopus laevis transcribed sequence with moderate similarity more 80.01(n)    BJ046783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11102 idibd1110 73.29(n)   338155  BC044352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109731 CG10973 38.95(n)
    28.49(a)
      39447  NM_001038913.2  NP_001034002.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons Fes1A1 Fes1A 39.15(n)
    26.55(a)
      820091  NM_111769.1  NP_566349.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08227001 Os03g0822700 41.94(n)
    28.36(a)
      4334611  NM_001058271.1  NP_001051736.1 


    ENSEMBL Gene Tree for HSPBP1 (if available)
    TreeFam Gene Tree for HSPBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPBP1 (see all 470)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855898401,2
    --55773128(+) ACCCAG/TCCACA 2 -- int10--------
    rs116658321,2
    C,F,H--55773152(+) GACACA/GGTGCA 2 -- int17Minor allele frequency- G:0.09NA CSA EA 249
    rs1398137461,2
    --55773162(+) AGCCTC/TCATCA 2 -- int10--------
    rs3730497101,2
    C--55773266(+) GGGCAA/GGGGCC 2 -- int10--------
    rs72464141,2
    C--55773275(+) CCCCTA/CCACCG 2 -- int10--------
    rs72462931,2
    C,F,H--55773284(+) CGCCAG/ACTCTT 2 -- int19Minor allele frequency- A:0.46WA NA CSA EA 368
    rs1116645051,2
    C,F--55773301(+) ACGACC/TGGCGG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs104031641,2
    C,F,A,H--55773590(+) GCTCTA/GTAGAT 2 -- spd130Minor allele frequency- G:0.42NS EA NA WA CSA 2774
    rs1468082071,2
    C--55773610(+) CAACAC/GTTTTA 2 -- ut310--------
    rs104033381,2
    C,F--55773615(+) CTTTTA/TTTATT 2 -- ut31 ese31Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for HSPBP1 (55773591 - 55791751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSPBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912454CNV Loss21882294
    nsv912457CNV Loss21882294
    nsv912459CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912458CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612939    OMIM disorders: --


    Find genes that share disorders with HSPBP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for HSPBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 40.4 1 15977250 (1)


    Export disorders for HSPBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPBP1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with HSPBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PubMed id 9830037)1, 2, 3, 9 Raynes D.A. and Guerriero V. Jr. (J. Biol. Chem. 1998)
    2. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PubMed id 10786638)1, 2, 3, 9 Guerriero V. Jr. and Raynes D.A. (Biochim. Biophys. Acta 2000)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. (PubMed id 15694338)1, 2 Shomura Y.... Bracher A. (Mol. Cell 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. (PubMed id 15215316)1, 2 Alberti S.... Hoehfeld J. (Mol. Biol. Cell 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain. (PubMed id 12651857)1, 2 McLellan C.A.... Guerriero V. Jr. (J. Biol. Chem. 2003)
    9. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PubMed id 16677834)1, 9 Gottwald E....Guerriero V. (Cell Biol. Int. 2006)
    10. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PubMed id 14503850)1, 9 Oh W.K. and Song J. (Mol. Cells 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23640 HGNC: 24989 AceView: HSPBP1 Ensembl:ENSG00000133265 euGenes: HUgn23640
    ECgene: HSPBP1 Kegg: 23640 H-InvDB: HSPBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPBP1 gene:
    Search GeneIP for patents involving HSPBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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