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Aliases for HSPBP1 Gene

Aliases for HSPBP1 Gene

  • HSPA (Hsp70) Binding Protein 1 2 3 5
  • HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1 2 3
  • Heat Shock Protein-Binding Protein 1 3 4
  • Hsp70 Interacting Protein 2 3
  • Hsp70-Interacting Protein 1 4
  • Hsp70-Interacting Protein 2 4
  • Hsp70-Binding Protein 1 3
  • Hsp70-Binding Protein 2 4
  • HspBP1 4
  • HspBP2 4
  • HSPBP 4
  • FES1 3

External Ids for HSPBP1 Gene

Previous GeneCards Identifiers for HSPBP1 Gene

  • GC19M056638
  • GC19M056198
  • GC19M060449
  • GC19M060465
  • GC19M055773
  • GC19M052097

Summaries for HSPBP1 Gene

GeneCards Summary for HSPBP1 Gene

HSPBP1 (HSPA (Hsp70) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Protein processing in endoplasmic reticulum. GO annotations related to this gene include binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for HSPBP1 Gene

  • Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Wiki entry for HSPBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBP1 Gene

Genomics for HSPBP1 Gene

Regulatory Elements for HSPBP1 Gene

Enhancers for HSPBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055246 1.7 Ensembl ENCODE dbSUPER 26.3 +26.5 26525 14.5 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC HSPBP1 TMEM86B NAT14 FIZ1 PPP6R1 BRSK1 RPL28 TMEM238 SYT5 UBE2S
GH19G055275 1.2 FANTOM5 Ensembl ENCODE 17.4 +3.6 3567 2.2 MTA2 BHLHE40 SIN3A CEBPB DPF2 ZNF623 TBX21 ARID3A NFYB SPI1 HSPBP1 KIR3DL2 KIR2DS4 ZNF628 NCR1 EPN1 PPP6R1 KMT5C KIR3DL1 GC19M055263
GH19G055337 1.8 FANTOM5 ENCODE dbSUPER 11.1 -59.4 -59445 4.0 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC LENG8-AS1 ENSG00000235681 U2AF2 FAM71E2 KMT5C PPP6R1 ZNF628 TMEM238 IL11 TMEM190
GH19G055215 1.5 ENCODE dbSUPER 11.5 +63.7 63679 2.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 LENG8-AS1 U2AF2 ENSG00000235681 ENSG00000267523 ZNF580 NAT14 ZNF581 FIZ1 ENSG00000267096 ENSG00000267265
GH19G055320 1.5 FANTOM5 Ensembl ENCODE 11 -42.9 -42943 5.7 PKNOX1 SCRT2 CREM CEBPB ELF1 ZNF592 ZNF579 SMARCA4 CEBPA IKZF1 FCAR TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 TMEM238 RPL28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPBP1 on UCSC Golden Path with GeneCards custom track

Promoters for HSPBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111619 283 1401 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143

Genomic Location for HSPBP1 Gene

Chromosome:
19
Start:
55,262,222 bp from pter
End:
55,280,383 bp from pter
Size:
18,162 bases
Orientation:
Minus strand

Genomic View for HSPBP1 Gene

Genes around HSPBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBP1 Gene

Proteins for HSPBP1 Gene

  • Protein details for HSPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL4-HPBP1_HUMAN
    Recommended name:
    Hsp70-binding protein 1
    Protein Accession:
    Q9NZL4
    Secondary Accessions:
    • B3KQP0
    • B4DG11
    • O95351
    • Q6ZNU5

    Protein attributes for HSPBP1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39474 Da
    Quaternary structure:
    • Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.

    Three dimensional structures from OCA and Proteopedia for HSPBP1 Gene

    Alternative splice isoforms for HSPBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPBP1 Gene

Post-translational modifications for HSPBP1 Gene

  • Ubiquitination at isoforms=2, 397, isoforms=3210, and posLast=248248
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for HSPBP1

No data available for DME Specific Peptides for HSPBP1 Gene

Domains & Families for HSPBP1 Gene

Protein Domains for HSPBP1 Gene

Suggested Antigen Peptide Sequences for HSPBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPBP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HSPBP1 Gene

Function for HSPBP1 Gene

Molecular function for HSPBP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Ontology (GO) - Molecular Function for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity TAS 9830037
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HSPBP1: view
genes like me logo Genes that share phenotypes with HSPBP1: view

Animal Models for HSPBP1 Gene

MGI Knock Outs for HSPBP1:

Animal Model Products

miRNA for HSPBP1 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPBP1 Gene

Localization for HSPBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPBP1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSPBP1 Gene

Pathways & Interactions for HSPBP1 Gene

genes like me logo Genes that share pathways with HSPBP1: view

Pathways by source for HSPBP1 Gene

Gene Ontology (GO) - Biological Process for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9830037
GO:0031398 positive regulation of protein ubiquitination IDA 16831871
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 16831871
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with HSPBP1: view

No data available for SIGNOR curated interactions for HSPBP1 Gene

Drugs & Compounds for HSPBP1 Gene

No Compound Related Data Available

Transcripts for HSPBP1 Gene

Unigene Clusters for HSPBP1 Gene

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for HSPBP1 Gene

GeneLoc Exon Structure for
HSPBP1
ECgene alternative splicing isoforms for
HSPBP1

Expression for HSPBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPBP1 Gene

Protein differential expression in normal tissues from HIPED for HSPBP1 Gene

This gene is overexpressed in Bone (27.2) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPBP1 Gene



Protein tissue co-expression partners for HSPBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPBP1 Gene:

HSPBP1

SOURCE GeneReport for Unigene cluster for HSPBP1 Gene:

Hs.53066

mRNA Expression by UniProt/SwissProt for HSPBP1 Gene:

Q9NZL4-HPBP1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HSPBP1 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Heart(4.3)
  • Spleen(4.2)
  • Pancreas(2.6)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with HSPBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPBP1 Gene

Orthologs for HSPBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPBP1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPBP1 34 35
  • 89.17 (n)
dog
(Canis familiaris)
Mammalia HSPBP1 34 35
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Hspbp1 34
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia Hspbp1 34 16 35
  • 86.46 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPBP1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPBP1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPBP1 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPBP1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspbp1 34
  • 63.47 (n)
Str.2669 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16057 34
zebrafish
(Danio rerio)
Actinopterygii hspbp1 34 35
  • 58.78 (n)
idibd1110 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.342 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008392 34
  • 48.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10973 34
  • 38.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Fes1A 34
  • 39.15 (n)
rice
(Oryza sativa)
Liliopsida Os03g0822700 34
  • 41.94 (n)
Species where no ortholog for HSPBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBP1 Gene

ENSEMBL:
Gene Tree for HSPBP1 (if available)
TreeFam:
Gene Tree for HSPBP1 (if available)

Paralogs for HSPBP1 Gene

No data available for Paralogs for HSPBP1 Gene

Variants for HSPBP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000144911 -- 55,280,969(+) CTCCC(G/T)TGTTG upstream-variant-2KB
rs1000229684 -- 55,269,832(+) GAGTG(C/T)GCCCC intron-variant
rs1000419104 -- 55,270,285(+) GAGCT(A/T)CCTGC intron-variant
rs1000434554 -- 55,263,713(+) CATAA(C/G)ATAGA intron-variant
rs1000619537 -- 55,268,804(+) GCCGA(A/G)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPBP1 Gene

Variant ID Type Subtype PubMed ID
esv3338654 CNV duplication 20981092

Variation tolerance for HSPBP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBP1 Gene

Disorders for HSPBP1 Gene

Relevant External Links for HSPBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPBP1

No disorders were found for HSPBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPBP1 Gene

Publications for HSPBP1 Gene

  1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PMID: 10786638) Guerriero V. Jr. … Raynes D.A. (Biochim. Biophys. Acta 2000) 2 3 4 22 64
  2. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PMID: 9830037) Raynes D.A. … Guerriero V. Jr. (J. Biol. Chem. 1998) 2 3 4 22 64
  3. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. (PMID: 17855353) Tanimura S. … Kohno M. (J. Biol. Chem. 2007) 3 22 64
  4. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PMID: 16677834) Gottwald E. … Guerriero V. (Cell Biol. Int. 2006) 3 22 64
  5. Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. (PMID: 15694338) Shomura Y. … Bracher A. (Mol. Cell 2005) 3 4 64

Products for HSPBP1 Gene

Sources for HSPBP1 Gene

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