Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPBP1 Gene

protein-coding   GIFtS: 54
GCID: GC19M055773

HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 11 2     FES12
Hsp70 Binding Protein 11 2     Hsp70-Binding Protein 12
Hsp70 Interacting Protein1 2     hspBP22
Heat Shock Protein-Binding Protein 12 3     HSPBP3
Hsp70-Binding Protein 22 3     HspBP13
Hsp70-Interacting Protein 12 3     HspBP23
Hsp70-Interacting Protein 22 3     

External Ids:    HGNC: 249891   Entrez Gene: 236402   Ensembl: ENSG000001332657   OMIM: 6129395   UniProtKB: Q9NZL43   

Export aliases for HSPBP1 gene to outside databases

Previous GC identifers: GC19M056638 GC19M056198 GC19M060449 GC19M060465 GC19M052097


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPBP1 Gene: 
HSPBP1 (HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1) is a protein-coding gene. Diseases associated with HSPBP1 include cystic fibrosis, and lung cancer, and among its related super-pathways are Regulation of degradation of deltaF508 CFTR in CF and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include enzyme inhibitor activity and protein binding.

UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and
interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted
degradation of immature CFTR

Gene Wiki entry for HSPBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPBP1 gene promoter:
         Spz1   MyoD   LUN-1   E47   Arnt   Roaz   C/EBPalpha   PPAR-gamma1   Cart-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

HSPBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPBP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055773:  view genomic region     (about GC identifiers)

Start:
55,773,591 bp from pter      End:
55,791,751 bp from pter
Size:
18,161 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4 (See protein sequence)
Recommended Name: Hsp70-binding protein 1  
Size: 362 amino acids; 39474 Da
Subunit: Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A
and HSPBP1
2 PDB 3D structures from and Proteopedia for HSPBP1:
1XQR (3D)        1XQS (3D)    
Secondary accessions: B3KQP0 O95351 Q6ZNU5
Alternative splicing: 2 isoforms:  Q9NZL4-1   Q9NZL4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HSPBP1: NX_Q9NZL4

Explore proteomics data for HSPBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZL4

  • HSPBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPBP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123578.1  NP_036399.3  

    ENSEMBL proteins: 
     ENSP00000255631   ENSP00000398244   ENSP00000467574   ENSP00000466569   ENSP00000466749  
     ENSP00000465876   ENSP00000465690   ENSP00000468403   ENSP00000467926   ENSP00000365521  

    Human Recombinant Protein Products for HSPBP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HSPBP1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HSPBP1
    GenScript Custom Purified and Recombinant Proteins Services for HSPBP1
    Novus Biologicals HSPBP1 Proteins
    Novus Biologicals HSPBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSPBP1
    Cloud-Clone Corp. Proteins for HSPBP1 


    HSPBP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HSPBP1
    OriGene Custom Antibody Services for HSPBP1
    GenScript Custom Superior Antibodies Services for HSPBP1
    Novus Biologicals HSPBP1 Antibodies
    Abcam antibodies for HSPBP1
    Cloud-Clone Corp. Antibodies for HSPBP1 
    ThermoFisher Antibodies for HSPBP1
    LSBio Antibodies in human, mouse, rat for HSPBP1 

    Assay Products for HSPBP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSPBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPBP1 
    Cloud-Clone Corp. CLIAs for HSPBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NZL4

    ProtoNet protein and cluster: Q9NZL4

    UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
    Similarity: Contains 4 ARM repeats


    HSPBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HPBP1_HUMAN, Q9NZL4
    Function: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and
    interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted
    degradation of immature CFTR

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004857enzyme inhibitor activity TAS9830037
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
         
    HSPBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSPBP1:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPBP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPBP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPBP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPBP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPBP1 (see all 10):
    hsa-miR-30c-2* hsa-miR-1321 hsa-miR-3138 hsa-miR-650 hsa-miR-661 hsa-miR-23b* hsa-miR-30c-1* hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidHSPBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPBP1
    Sirion Biotech Customized adenovirus for overexpression of HSPBP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSPBP1 (see all 13)
    OriGene ORF clones in mouse, rat for HSPBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSPBP1 (NM_001130106)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBP1
    Sirion Biotech Customized lentivirus for stable overexpression of HSPBP1 
                         Customized lentivirus expression plasmids for stable overexpression of HSPBP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSPBP1
    Search LifeMap BioReagents cell lines for HSPBP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of wt-CFTR
    Regulation of degradation of wt-CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2CFTR folding and maturation (norm and CF)
    CFTR folding and maturation (norm and CF)0.37
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for HSPBP1
        Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Regulation of degradation of wt-CFTR


    1         Kegg Pathway  (Kegg details for HSPBP1):
        Protein processing in endoplasmic reticulum


    HSPBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/32 Interacting proteins for HSPBP1 (Q9NZL41, 2, 3 ENSP000002556314) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232804P081072, 3, ENSP000003930874MINT-2871494 I2D: score=7 STRING: ENSP00000393087
    ENSG00000212866P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000215328P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000224501P081072, 3MINT-2871494 I2D: score=7 
    ENSG00000231555P081072, 3MINT-2871494 I2D: score=7 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS9830037
    GO:0031398positive regulation of protein ubiquitination IDA16831871
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA16831871
    GO:0043086negative regulation of catalytic activity TAS9830037

    HSPBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPBP1 (HPBP1)

    Search CenterWatch for drugs/clinical trials and news about HSPBP1 / HPBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPBP1 gene (2 alternative transcripts): 
    NM_001130106.1  NM_012267.4  

    Unigene Cluster for HSPBP1:

    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
    Hs.53066  [show with all ESTs]
    Unigene Representative Sequence: NM_012267
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255631(uc002qjx.3 uc002qkd.3) ENST00000433386(uc002qkc.3)
    ENST00000587922 ENST00000585927 ENST00000587959 ENST00000593263 ENST00000585698
    ENST00000588971 ENST00000587551 ENST00000376343
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPBP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPBP1 (see all 10):
    hsa-miR-30c-2* hsa-miR-1321 hsa-miR-3138 hsa-miR-650 hsa-miR-661 hsa-miR-23b* hsa-miR-30c-1* hsa-miR-3170
    SwitchGear 3'UTR luciferase reporter plasmidHSPBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPBP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for HSPBP1 (see all 13)
    OriGene ORF clones in mouse, rat for HSPBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSPBP1 (NM_001130106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBP1
    Sirion Biotech Customized lentivirus for stable overexpression of HSPBP1 
                         Customized lentivirus expression plasmids for stable overexpression of HSPBP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPBP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPBP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPBP1

    Additional mRNA sequence: 

    AB020592.1 AF093420.1 AF187859.1 AF217996.1 AK075293.1 AK129755.1 AK130636.1 AK130781.1 
    AK294358.1 BC001236.1 BC002373.2 CR457118.1 

    22 DOTS entries:

    DT.75165530  DT.101978247  DT.100879806  DT.100879808  DT.100879813  DT.121426668  DT.40131409  DT.100030991 
    DT.100696204  DT.100879812  DT.100692913  DT.100879822  DT.100879823  DT.121426634  DT.100030986  DT.100728600 
    DT.100879809  DT.100879825  DT.121426625  DT.92448196  DT.92448199  DT.95164315 

    24/459 AceView cDNA sequences (see all 459):

    CA432164 BM819046 AI183652 CR590595 BM675282 CR615864 CA424918 AB020592 
    BM263186 BU160496 H84150 BQ717412 BM975882 BI118072 AA769453 CA417869 
    BM675307 BM824654 AI891019 BG387924 BM984258 AI066417 BM989354 AI816466 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                                                                  
    SP2:              -                 -                                                                                 
    SP3:              -                 -                                                                                 
    SP4:                                                                                                                  
    SP5:                                                        -                                                         


    ECgene alternative splicing isoforms for HSPBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCACTCT
    HSPBP1 Expression
    About this image


    See HSPBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPBP1

    SOURCE GeneReport for Unigene cluster: Hs.53066

    UniProtKB/Swiss-Prot: HPBP1_HUMAN, Q9NZL4
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for HSPBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPBP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPBP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPBP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPBP1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspbp11 , 5 HSPA (heat shock 70kDa) binding protein, cytoplasmic more1, 5 87.86(n)1
    95.52(a)1
      7 (2.69 cM)5
    662451  NM_024172.31  NP_077134.11 
     46605215 
    chicken
    (Gallus gallus)
    Aves HSPBP16
    HSPA (heat shock 70kDa) binding protein, cytoplasm...
    46(a)
    1 ↔ 1
    AADN03025554.1(21-2670)
    lizard
    (Anolis carolinensis)
    Reptilia HSPBP16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343355.1(1113982-1132574)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160572 Xenopus laevis transcribed sequence with moderate similarity more 80.01(n)    BJ046783.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11102 idibd1110 73.29(n)   338155  BC044352.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109731 CG10973 39.2(n)
    28.14(a)
      39447  NM_001038913.1  NP_001034002.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons Fes1A1 protein Fes1A 39.53(n)
    26.58(a)
      820091  NM_111769.1  NP_566349.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08227001 hypothetical protein 42.28(n)
    28.86(a)
      4334611  NM_001058271.1  NP_001051736.1 


    ENSEMBL Gene Tree for HSPBP1 (if available)
    TreeFam Gene Tree for HSPBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/470 SNPs in HSPBP1 are shown (see all 470)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855898401,2
    --55773128(+) ACCCAG/TCCACA 2 -- int10--------
    rs116658321,2
    C,F,H--55773152(+) GACACA/GGTGCA 2 -- int17Minor allele frequency- G:0.09NA CSA EA 249
    rs1398137461,2
    --55773162(+) AGCCTC/TCATCA 2 -- int10--------
    rs3730497101,2
    C--55773266(+) GGGCAA/GGGGCC 2 -- int10--------
    rs72464141,2
    C--55773275(+) CCCCTA/CCACCG 2 -- int10--------
    rs72462931,2
    C,F,H--55773284(+) CGCCAG/ACTCTT 2 -- int19Minor allele frequency- A:0.46WA NA CSA EA 368
    rs1116645051,2
    C,F--55773301(+) ACGACC/TGGCGG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs104031641,2
    C,F,A,H--55773590(+) GCTCTA/GTAGAT 2 -- spd130Minor allele frequency- G:0.42NS EA NA WA CSA 2774
    rs1468082071,2
    C--55773610(+) CAACAC/GTTTTA 2 -- ut310--------
    rs104033381,2
    C,F--55773615(+) CTTTTA/TTTATT 2 -- ut31 ese31Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for HSPBP1 (55773591 - 55791751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSPBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912454CNV Loss21882294
    nsv912457CNV Loss21882294
    nsv912459CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912458CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612939    OMIM disorders: --

    4 diseases for HSPBP1:    About MalaCards
    cystic fibrosis    lung cancer    gastric cancer    leukemia


    HSPBP1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HSPBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 40.4 1 15977250 (1)


    Export disorders for HSPBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPBP1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with HSPBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PubMed id 9830037)1, 2, 3, 9 Raynes D.A. and Guerriero V. Jr. (1998)
    2. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PubMed id 10786638)1, 2, 3, 9 Guerriero V. Jr. and Raynes D.A. (2000)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. (PubMed id 15694338)1, 2 Shomura Y.... Bracher A. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. (PubMed id 15215316)1, 2 Alberti S.... Hoehfeld J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. HspBP1, an Hsp70 cochaperone, has two structural domains and is capable of altering the conformation of the Hsp70 ATPase domain. (PubMed id 12651857)1, 2 McLellan C.A.... Guerriero V. Jr. (2003)
    9. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PubMed id 16677834)1, 9 Gottwald E....Guerriero V. (2006)
    10. Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation. (PubMed id 14503850)1, 9 Oh W.K. and Song J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23640 HGNC: 24989 AceView: HSPBP1 Ensembl:ENSG00000133265 euGenes: HUgn23640
    ECgene: HSPBP1 Kegg: 23640 H-InvDB: HSPBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPBP1 gene:
    Search GeneIP for patents involving HSPBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HSPBP1   OriGene RNAi products in human, mouse, rat for HSPBP1  
     OriGene qPCR primer pairs and template standards for HSPBP1   OriGene Protein Over-expression Lysate for HSPBP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HSPBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSPBP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HSPBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPBP1   OriGene Custom Protein Services for HSPBP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPBP1
     QIAGEN SeqTarget long-range PCR primers for resequencing HSPBP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPBP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPBP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPBP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPBP1
     GenScript Custom Purified and Recombinant Proteins Services for HSPBP1 GenScript cDNA clones with any tag delivered in your preferred vector for HSPBP1
     GenScript Custom Assay Services for HSPBP1 GenScript Custom Superior Antibodies Services for HSPBP1
     GenScript Custom overexpressing Cell Line Services for HSPBP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSPBP1 promoter
     Search Chromatin IP Primers for HSPBP1
     RT2 qPCR Primer Assay in human, mouse, rat HSPBP1
     GNC Network for HSPBP1
     SABiosciences Custom PCR Arrays for HSPBP1
     Search Tocris compounds for HSPBP1 (HPBP1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSPBP1 antibodies
     HSPBP1 proteins
     HSPBP1 lysates
     Antibodies for HSPBP1
     See all of Abcam's Antibodies, Kits and Proteins for HSPBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSPBP1




     Proteins for HSPBP1
     Antibodies for HSPBP1
     ELISAs for HSPBP1
     CLIAs for HSPBP1
     Search LifeMap BioReagents cell lines for HSPBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBP1
     SwitchGear 3'UTR luciferase reporter plasmids for HSPBP1
     SwitchGear Promoter luciferase reporter plasmids for HSPBP1
     ThermoFisher Antibodies for HSPBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPBP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPBP1
    Customized:
     lentivirus for stable overexpression of HSPBP1
     lentivirus expression plasmids for stable overexpression of HSPBP1
     adenovirus for overexpression of HSPBP1
     LSBio Antibodies in human, mouse, rat for HSPBP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSPBP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4