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Aliases for HSPBP1 Gene

Aliases for HSPBP1 Gene

  • HSPA (Hsp70) Binding Protein 1 2 3 5
  • HSPA (Heat Shock 70kDa) Binding Protein, Cytoplasmic Cochaperone 1 2 3
  • Heat Shock Protein-Binding Protein 1 3 4
  • Hsp70 Interacting Protein 2 3
  • Hsp70-Interacting Protein 1 4
  • Hsp70-Interacting Protein 2 4
  • Hsp70-Binding Protein 1 3
  • Hsp70-Binding Protein 2 4
  • HspBP1 4
  • HspBP2 4
  • HSPBP 4
  • FES1 3

External Ids for HSPBP1 Gene

Previous GeneCards Identifiers for HSPBP1 Gene

  • GC19M056638
  • GC19M056198
  • GC19M060449
  • GC19M060465
  • GC19M055773
  • GC19M052097

Summaries for HSPBP1 Gene

GeneCards Summary for HSPBP1 Gene

HSPBP1 (HSPA (Hsp70) Binding Protein 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for HSPBP1 Gene

  • Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Gene Wiki entry for HSPBP1 Gene

Additional gene information for HSPBP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBP1 Gene

Genomics for HSPBP1 Gene

Regulatory Elements for HSPBP1 Gene

Enhancers for HSPBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H055246 1.7 Ensembl ENCODE dbSUPER 26.3 +26.5 26525 14 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 LENG8 LENG8-AS1 U2AF2 ZNF628 ENSG00000235681 ZNF581 BRSK1 HSPBP1 FIZ1 TMEM86B
GH19H055337 1.8 FANTOM5 ENCODE dbSUPER 11.1 -59.4 -59445 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ZNF628 FAM71E2 SSC5D KMT5C PPP6R1 LOC729999
GH19H055275 1.1 FANTOM5 Ensembl ENCODE 17.4 +3.6 3567 2 CEBPB DPF2 RUNX3 ZNF623 SPI1 HSPBP1 KIR3DL2 KIR2DS4 ZNF628 NCR1 EPN1 PPP6R1 KMT5C KIR3DL1 GC19M055263
GH19H055215 1.5 ENCODE dbSUPER 11.5 +63.7 63679 2 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC LENG8-AS1 U2AF2 LENG8 ENSG00000235681 ENSG00000267523 SSC5D ZNF580 ZNF628 ENSG00000267096 BRSK1
GH19H055320 1.4 FANTOM5 Ensembl ENCODE 11 -42.9 -42943 5 BACH1 CEBPG ZNF384 ZNF316 POLR2A SCRT2 NFE2 MAFK CREM SMARCE1 FCAR TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 TMEM238 RPL28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPBP1 on UCSC Golden Path with GeneCards custom track

Promoters for HSPBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111619 283 1401 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK

Genomic Location for HSPBP1 Gene

Chromosome:
19
Start:
55,262,222 bp from pter
End:
55,280,383 bp from pter
Size:
18,162 bases
Orientation:
Minus strand

Genomic View for HSPBP1 Gene

Genes around HSPBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBP1 Gene

Proteins for HSPBP1 Gene

  • Protein details for HSPBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZL4-HPBP1_HUMAN
    Recommended name:
    Hsp70-binding protein 1
    Protein Accession:
    Q9NZL4
    Secondary Accessions:
    • B3KQP0
    • B4DG11
    • O95351
    • Q6ZNU5

    Protein attributes for HSPBP1 Gene

    Size:
    362 amino acids
    Molecular mass:
    39474 Da
    Quaternary structure:
    • Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.

    Three dimensional structures from OCA and Proteopedia for HSPBP1 Gene

    Alternative splice isoforms for HSPBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPBP1 Gene

Post-translational modifications for HSPBP1 Gene

  • Ubiquitination at posLast=9797, isoforms=3210, and posLast=248248
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for HSPBP1 Gene

Domains & Families for HSPBP1 Gene

Gene Families for HSPBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPBP1 Gene

Suggested Antigen Peptide Sequences for HSPBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPBP1: view

No data available for UniProtKB/Swiss-Prot for HSPBP1 Gene

Function for HSPBP1 Gene

Molecular function for HSPBP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Phenotypes From GWAS Catalog for HSPBP1 Gene

Gene Ontology (GO) - Molecular Function for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity TAS 9830037
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with HSPBP1: view
genes like me logo Genes that share phenotypes with HSPBP1: view

Animal Models for HSPBP1 Gene

MGI Knock Outs for HSPBP1:

Animal Model Products

CRISPR Products

miRNA for HSPBP1 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSPBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPBP1 Gene

Localization for HSPBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPBP1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSPBP1 Gene

Pathways & Interactions for HSPBP1 Gene

genes like me logo Genes that share pathways with HSPBP1: view

Pathways by source for HSPBP1 Gene

Gene Ontology (GO) - Biological Process for HSPBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9830037
GO:0031398 positive regulation of protein ubiquitination IDA 16831871
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 16831871
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with HSPBP1: view

No data available for SIGNOR curated interactions for HSPBP1 Gene

Drugs & Compounds for HSPBP1 Gene

No Compound Related Data Available

Transcripts for HSPBP1 Gene

Unigene Clusters for HSPBP1 Gene

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSPBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBP1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2: - -
SP3: - -
SP4:
SP5: -
SP6: -
SP7:

Relevant External Links for HSPBP1 Gene

GeneLoc Exon Structure for
HSPBP1
ECgene alternative splicing isoforms for
HSPBP1

Expression for HSPBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPBP1 Gene

Protein differential expression in normal tissues from HIPED for HSPBP1 Gene

This gene is overexpressed in Bone (27.2) and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPBP1 Gene



Protein tissue co-expression partners for HSPBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPBP1 Gene:

HSPBP1

SOURCE GeneReport for Unigene cluster for HSPBP1 Gene:

Hs.53066

mRNA Expression by UniProt/SwissProt for HSPBP1 Gene:

Q9NZL4-HPBP1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for HSPBP1 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Heart(4.3)
  • Spleen(4.2)
  • Pancreas(2.6)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with HSPBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPBP1 Gene

Orthologs for HSPBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPBP1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPBP1 33 34
  • 89.17 (n)
dog
(Canis familiaris)
Mammalia HSPBP1 33 34
  • 88.52 (n)
rat
(Rattus norvegicus)
Mammalia Hspbp1 33
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia Hspbp1 33 16 34
  • 86.46 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPBP1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPBP1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPBP1 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPBP1 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspbp1 33
  • 63.47 (n)
Str.2669 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16057 33
zebrafish
(Danio rerio)
Actinopterygii hspbp1 33 34
  • 58.78 (n)
idibd1110 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.342 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008392 33
  • 48.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10973 33
  • 38.95 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Fes1A 33
  • 39.15 (n)
rice
(Oryza sativa)
Liliopsida Os03g0822700 33
  • 41.94 (n)
Species where no ortholog for HSPBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBP1 Gene

ENSEMBL:
Gene Tree for HSPBP1 (if available)
TreeFam:
Gene Tree for HSPBP1 (if available)

Paralogs for HSPBP1 Gene

No data available for Paralogs for HSPBP1 Gene

Variants for HSPBP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000144911 -- 55,280,969(+) CTCCC(G/T)TGTTG upstream-variant-2KB
rs1000229684 -- 55,269,832(+) GAGTG(C/T)GCCCC intron-variant
rs1000419104 -- 55,270,285(+) GAGCT(A/T)CCTGC intron-variant
rs1000434554 -- 55,263,713(+) CATAA(C/G)ATAGA intron-variant
rs1000619537 -- 55,268,804(+) GCCGA(A/G)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPBP1 Gene

Variant ID Type Subtype PubMed ID
esv3338654 CNV duplication 20981092

Variation tolerance for HSPBP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBP1 Gene

Disorders for HSPBP1 Gene

Relevant External Links for HSPBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPBP1

No disorders were found for HSPBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPBP1 Gene

Publications for HSPBP1 Gene

  1. Isolation and characterization of isoforms of HspBP1, inhibitors of Hsp70. (PMID: 10786638) Raynes DA … Guerriero V (Biochimica et biophysica acta 2000) 2 3 4 22 60
  2. Inhibition of Hsp70 ATPase activity and protein renaturation by a novel Hsp70-binding protein. (PMID: 9830037) Raynes DA … Guerriero V (The Journal of biological chemistry 1998) 2 3 4 22 60
  3. Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells. (PMID: 17855353) Tanimura S … Kohno M (The Journal of biological chemistry 2007) 3 22 60
  4. Expression of the cochaperone HspBP1 is not coordinately regulated with Hsp70 expression. (PMID: 16677834) Gottwald E … Guerriero V (Cell biology international 2006) 3 22 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60

Products for HSPBP1 Gene

Sources for HSPBP1 Gene

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