HSPBAP1 Gene
protein-coding GIFtS: 51
GCID: GC03M122407
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HSPB (heat shock 27kDa) associated protein 1(Previous name: HSPB (heat shock 27kD) associated protein 1 )
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Aliases
for HSPBAP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HSPB (Heat Shock 27kDa) Associated Protein 11 2 | | HSPB (Heat Shock 27kD) Associated Protein 11 | | PASS11 2 3 | | HSPB1-Associated Protein 12 | | 27 KDa Heat Shock Protein-Associated Protein 12 3 | | Protein Associating With Small Stress Protein PASS12 | | FLJ226231 | | Protein Associated With Small Stress Protein 13 |
Export aliases for HSPBAP1 gene to outside databasesPrevious GC identifers: GC03M119179 GC03M123740 GC03M123779 GC03M123941 GC03M119832 |
Summaries
for HSPBAP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HSPBAP1:
This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involvedwith cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients withintractable epilepsy, although how brain function is affected remains unknown. (provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2Function: May play a role in cellular stress response (By similarity)
|
Genomic Views
for HSPBAP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSPBAP1 gene promoter:
C/EBPbeta p53 POU3F2 GATA-1 c-Ets-1 Evi-1 AREB6 HEN1 FAC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSPBAP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPBAP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1HSPBAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M122407: view genomic region
(about GC identifiers)
Start:
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122,458,846 bp from pter |
End:
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122,512,671 bp from pter |
Size:
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53,826 bases |
Orientation:
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minus strand |
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Proteins
for HSPBAP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2 (See
protein sequence)Recommended Name: HSPB1-associated protein 1 Size: 488 amino acids; 55167 Da
Subunit: Interacts with CRYAB and HSPB1
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH17763.1; Type=Erroneous initiation;
Secondary accessions: Q6P476 Q8N8J4 Q8NHH6 Q8WWF0Alternative splicing: 3 isoforms: Q96EW2-1 Q96EW2-2 Q96EW2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HSPBAP1: NX_Q96EW2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EW2
HSPBAP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078886.2
ENSEMBL proteins: ENSP00000302562 ENSP00000373155
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
HSPBAP1 for ontologies About GeneDecksing
HSPBAP1 Antibody Products:
Assay Products for HSPBAP1: |
Protein
Domains /
Families
for HSPBAP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSPBAP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96EW2ProtoNet protein and cluster: Q96EW2 1 Blocks protein family: IPB003347 Transcription factor jumonji
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2Similarity: Contains 1 JmjC domain |
Function
for HSPBAP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2Function: May play a role in cellular stress response (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBAP1 |
1 GenomeRNAi human phenotype for HSPBAP1:
|
Pathways & Interactions
for HSPBAP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPBAP1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for HSPBAP1 (Q96EW22, 3 ENSP000003025624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HSPBAP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSPBAP1
Search CenterWatch for drugs/clinical trials and news about HSPBAP1 / HBAP1
|
Transcripts
for HSPBAP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSPBAP1 gene: NM_024610.5 Unigene Cluster for HSPBAP1: HSPB (heat shock 27kDa) associated protein 1 Hs.29169 [show with all ESTs]Unigene Representative Sequence: AK0967057 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471534(uc003eft.2) ENST00000306103(uc003efu.2) ENST00000465044
ENST00000467643 ENST00000478601 ENST00000463266 ENST00000383659(uc003efv.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HSPBAP1 (NM_024610) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSPBAP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBAP1 |
Additional cDNA sequence: AF400663.1 AK026276.1 AK096705.1 AK289410.1 BC011897.2 BC017763.1 BC063629.1 4 DOTS entries: DT.313932 DT.100747296 DT.95253649 DT.100679139 24/108 AceView cDNA sequences (see all 108): BC011897 BM742997 BU630355 AA909433 AW243355 AI985348 NM_024610 AI432143 BQ013958 BQ574164 BU753569 CR598288 AK026276 BU194167 BM558864 BM683079 BM987235 AL543460 AA812771 CR617201 BM975491 AA776877 BM989184 AI867878
GeneLoc Exon Structure
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Expression
for HSPBAP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSPBAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACATTCCTC
About this image
See HSPBAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPBAP1
SOURCE GeneReport for Unigene cluster: Hs.29169
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Arrays including HSPBAP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPBAP1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBAP1 |
Orthologs
for HSPBAP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HSPBAP1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HSPBAP11 |
HSPB (heat shock 27kDa) associated protein 1 |
68.04(n)
62.39(a) |
|
424245 XM_422094.3 XP_422094.3 |
lizard
(Anolis carolinensis) |
Reptilia |
HSPBAP16 |
-- |
52(a) |
1 ↔ 1 |
1(83415810-83469946) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.208282 |
Xenopus laevis transcribed sequence |
81.47(n) |
|
BQ884385.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hspbap11 |
hspb associated protein 1 |
57.71(n)
52.8(a) |
|
445320 NM_001003777.1 NP_001003777.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG433206 |
-- |
24(a) |
1 ↔ 1 |
3R(23520977-23522173) |
ENSEMBL Gene Tree for HSPBAP1 (if available)
TreeFam Gene Tree for HSPBAP1 (if available) |
Paralogs
for HSPBAP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HSPBAP1 gene
- TYW52 JMJD72 KDM82 HIF1AN2
HSPBAP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HSPBAP1
PGOHUM00000247588
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Genomic Variants
for HSPBAP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSPBAP1 (122458846 - 122512671 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HSPBAP1
4 CNVs: 79870 91504 91503 91505 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPBAP1 |
|
Disorders
/ Diseases
for HSPBAP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSPBAP1 for disorders About GeneDecksing
OMIM gene information: 608263
OMIM disorders: --
UniProtKB/Swiss-Prot: HBAP1_HUMAN, Q96EW2
Note=A chromosomal aberration involving HSPBAP1 has been found in a family with renal carcinoma. Translocationt(2;3)(q35;q21) with the putative pseudogene DIRC3. Produces a hybrid mRNA encoding a truncated HSPBAP1 lacking thefirst 36 amino acids
1  disease for HSPBAP1: About MalaCardsintractable epilepsy
Export disorders for HSPBAP1 gene to outside databases
|
Publications
for HSPBAP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSPBAP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSPBAP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain. (PubMed id 11978969)1, 2, 3, 9 Jiang M.... Mao Y. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy. (PubMed id 17568411)1 Xi Z.Q....Guan L.F. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21). (PubMed id 12939738)2 Bodmer D....Geurts van Kessel A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27. (PubMed id 10751411)2 Liu C.... Welsh M.J. (2000)
|
External Searches for HSPBAP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSPBAP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSPBAP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSPBAP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HSPBAP1 gene:
Search GeneIP for patents involving HSPBAP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSPBAP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HSPBAP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPBAP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPBAP1 | | | OriGene Protein Over-expression Lysate for HSPBAP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSPBAP1 | | OriGene 3'-UTR Clone for HSPBAP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPBAP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HSPBAP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HSPBAP1 | | OriGene Custom Protein Services for HSPBAP1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPBAP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPBAP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPBAP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPBAP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPBAP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPBAP1 |
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 | | | HSPBAP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPBAP1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPBAP1 |
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