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Aliases for HSPBAP1 Gene

Aliases for HSPBAP1 Gene

  • HSPB (Heat Shock 27kDa) Associated Protein 1 2 3
  • 27 KDa Heat Shock Protein-Associated Protein 1 3 4
  • PASS1 3 4
  • Protein Associating With Small Stress Protein PASS1 3
  • Protein Associated With Small Stress Protein 1 4
  • HSPB (Heat Shock 27kD) Associated Protein 1 2
  • HSPB1-Associated Protein 1 3

External Ids for HSPBAP1 Gene

Previous GeneCards Identifiers for HSPBAP1 Gene

  • GC03M119179
  • GC03M122407
  • GC03M123740
  • GC03M123779
  • GC03M123941
  • GC03M119832

Summaries for HSPBAP1 Gene

Entrez Gene Summary for HSPBAP1 Gene

  • This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011]

GeneCards Summary for HSPBAP1 Gene

HSPBAP1 (HSPB (Heat Shock 27kDa) Associated Protein 1) is a Protein Coding gene. An important paralog of this gene is HIF1AN.

UniProtKB/Swiss-Prot for HSPBAP1 Gene

  • May play a role in cellular stress response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPBAP1 Gene

Genomics for HSPBAP1 Gene

Regulatory Elements for HSPBAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPBAP1 Gene

122,739,997 bp from pter
122,793,824 bp from pter
53,828 bases
Minus strand

Genomic View for HSPBAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPBAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPBAP1 Gene

Proteins for HSPBAP1 Gene

  • Protein details for HSPBAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HSPB1-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6P476
    • Q8N8J4
    • Q8NHH6
    • Q8WWF0

    Protein attributes for HSPBAP1 Gene

    488 amino acids
    Molecular mass:
    55167 Da
    Quaternary structure:
    • Interacts with CRYAB and HSPB1.
    • Sequence=AAH17763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPBAP1 Gene


neXtProt entry for HSPBAP1 Gene

Proteomics data for HSPBAP1 Gene at MOPED

Post-translational modifications for HSPBAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPBAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPBAP1 Gene

Domains for HSPBAP1 Gene

Protein Domains for HSPBAP1 Gene

Suggested Antigen Peptide Sequences for HSPBAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96EW2
  • Contains 1 JmjC domain.
genes like me logo Genes that share domains with HSPBAP1: view

No data available for Gene Families for HSPBAP1 Gene

Function for HSPBAP1 Gene

Molecular function for HSPBAP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cellular stress response.

Gene Ontology (GO) - Molecular Function for HSPBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSPBAP1: view

Phenotypes for HSPBAP1 Gene

GenomeRNAi human phenotypes for HSPBAP1:
genes like me logo Genes that share phenotypes with HSPBAP1: view

Animal Model Products

CRISPR Products

miRNA for HSPBAP1 Gene

miRTarBase miRNAs that target HSPBAP1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPBAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPBAP1 Gene

Localization for HSPBAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPBAP1 Gene


Subcellular locations from

Jensen Localization Image for HSPBAP1 Gene COMPARTMENTS Subcellular localization image for HSPBAP1 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPBAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSPBAP1: view

Pathways for HSPBAP1 Gene

SuperPathways for HSPBAP1 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for HSPBAP1 Gene


No data available for Pathways by source for HSPBAP1 Gene

Transcripts for HSPBAP1 Gene

Unigene Clusters for HSPBAP1 Gene

HSPB (heat shock 27kDa) associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPBAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPBAP1 Gene

No ASD Table

Relevant External Links for HSPBAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPBAP1 Gene

mRNA expression in normal human tissues for HSPBAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPBAP1 Gene

This gene is overexpressed in Whole Blood (5.6).

Protein differential expression in normal tissues for HSPBAP1 Gene

This gene is overexpressed in Testis (33.1), Placenta (14.3), and Peripheral blood mononuclear cells (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSPBAP1 Gene

SOURCE GeneReport for Unigene cluster for HSPBAP1 Gene Hs.29169

mRNA Expression by UniProt/SwissProt for HSPBAP1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with HSPBAP1: view

Expression partners for HSPBAP1 Gene

In Situ Assay Products

Orthologs for HSPBAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPBAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPBAP1 35
  • 87.14 (n)
  • 81.54 (a)
  • 81 (a)
(Canis familiaris)
Mammalia HSPBAP1 35
  • 86.79 (n)
  • 81.72 (a)
  • 77 (a)
(Mus musculus)
Mammalia Hspbap1 35
  • 78.29 (n)
  • 73.7 (a)
Hspbap1 16
Hspbap1 36
  • 74 (a)
(Pan troglodytes)
Mammalia HSPBAP1 35
  • 99.45 (n)
  • 98.98 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Hspbap1 35
  • 78.78 (n)
  • 74.32 (a)
(Monodelphis domestica)
Mammalia HSPBAP1 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HSPBAP1 36
  • 48 (a)
(Gallus gallus)
Aves HSPBAP1 35
  • 68.05 (n)
  • 62.45 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia HSPBAP1 36
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20828 35
(Danio rerio)
Actinopterygii hspbap1 35
  • 57.29 (n)
  • 53.02 (a)
hspbap1 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43320 36
  • 23 (a)
Species with no ortholog for HSPBAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPBAP1 Gene

Gene Tree for HSPBAP1 (if available)
Gene Tree for HSPBAP1 (if available)

Paralogs for HSPBAP1 Gene

Paralogs for HSPBAP1 Gene Pseudogenes for HSPBAP1 Gene

genes like me logo Genes that share paralogs with HSPBAP1: view

Variants for HSPBAP1 Gene

Sequence variations from dbSNP and Humsavar for HSPBAP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3115 -- 122,740,040(+) GCCGG(C/T)TGGTC utr-variant-3-prime
rs16338 -- 122,740,443(+) GTTTG(-/AAG/AGA)GAGGA cds-indel
rs869130 -- 122,792,659(-) TTGAC(C/T)TTGTG intron-variant
rs951350 -- 122,758,711(+) CAACA(C/T)AGAAA intron-variant
rs955982 -- 122,766,620(+) AATGG(A/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPBAP1 Gene

Variant ID Type Subtype PubMed ID
nsv877391 CNV Gain 21882294
nsv829705 CNV Loss 17160897
nsv822228 CNV Loss 20364138
nsv3975 CNV Loss 18451855
esv1422853 CNV Deletion 17803354

Relevant External Links for HSPBAP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPBAP1 Gene

Disorders for HSPBAP1 Gene


  • Note=A chromosomal aberration involving HSPBAP1 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21) with the putative pseudogene DIRC3. Produces a hybrid mRNA encoding a truncated HSPBAP1 lacking the first 36 amino acids.

No disorders were found for HSPBAP1 Gene.

No data available for MalaCards , OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HSPBAP1 Gene

Publications for HSPBAP1 Gene

  1. Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain. (PMID: 11978969) Jiang M. … Mao Y. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy. (PMID: 17568411) Xi Z.Q. … Guan L.F. (Synapse 2007) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for HSPBAP1 Gene

Sources for HSPBAP1 Gene

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