HSPB9 Gene
protein-coding GIFtS: 40
GCID: GC17P040274
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heat shock protein, alpha-crystallin-related, B9
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Aliases
for HSPB9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heat Shock Protein, Alpha-Crystallin-Related, B91 2 | | CT511 2 3 | | Cancer/Testis Antigen 512 3 | | Heat Shock Protein Beta-92 | | Small Heat Shock Protein B92 | | HspB93 |
Export aliases for HSPB9 gene to outside databasesPrevious GC identifers: GC17P040648 GC17P037526 GC17P036039 |
Summaries
for HSPB9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HSPB9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSPB9 gene promoter:
ER-alpha STAT1 STAT4 STAT6 STAT1beta STAT5A Egr-4 STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSPB9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21HSPB9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P040274: view genomic region
(about GC identifiers)
Start:
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40,274,756 bp from pter |
End:
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40,275,371 bp from pter |
Size:
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616 bases |
Orientation:
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plus strand |
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Proteins
for HSPB9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSPB9_HUMAN, Q9BQS6 (See
protein sequence)Recommended Name: Heat shock protein beta-9 Size: 159 amino acids; 17486 Da
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock
Secondary accessions: B3KSG6 Q52LB4Explore the universe of human proteins at neXtProt for HSPB9: NX_Q9BQS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQS6
HSPB9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149971.1
ENSEMBL proteins: ENSP00000347178
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HSPB9 for ontologies About GeneDecksing
HSPB9 Antibody Products:
Assay Products for HSPB9: |
Protein
Domains /
Families
for HSPB9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSPB9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BQS6ProtoNet protein and cluster: Q9BQS6 UniProtKB/Swiss-Prot: HSPB9_HUMAN, Q9BQS6Similarity: Belongs to the small heat shock protein (HSP20) family |
Function
for HSPB9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSPB9 (NM_033194) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSPB9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB9 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
HSPB9 for ontologies About GeneDecksing
|
Pathways & Interactions
for HSPB9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPB9
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for HSPB9 (Q9BQS61, 3 ENSP000003471784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006950 | response to stress |
IEA | -- |
HSPB9 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSPB9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSPB9
Search CenterWatch for drugs/clinical trials and news about HSPB9
|
Transcripts
for HSPB9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSPB9 gene: NM_033194.2 Unigene Cluster for HSPB9: Heat shock protein, alpha-crystallin-related, B9 Hs.620611 [show with all ESTs]Unigene Representative Sequence: AK0934881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000355067(uc002hyy.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HSPB9 (NM_033194) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSPB9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB9 |
Additional cDNA sequence: AK093488.1 AK130947.1 BC093991.1 BC093993.1 2 DOTS entries: DT.307371 DT.100782516 24/31 AceView cDNA sequences (see all 31): NM_033194 AK130947 AW003364 AW770522 AI203146 AI279609 BM511126 AW016818 BG149654 CK823778 AA988974 BU789224 BX280091 BF439726 BM511386 AK093488 AI203424 AX748161 AI915332 BE348524 AW206211 AA609498 AI038545 BF110255
GeneLoc Exon Structure
|
Expression
for HSPB9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSPB9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HSPB9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPB9
SOURCE GeneReport for Unigene cluster: Hs.620611
UniProtKB/Swiss-Prot: HSPB9_HUMAN, Q9BQS6Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for HSPB9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB9
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSPB9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB9 |
Orthologs
for HSPB9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for HSPB9 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Hspb91 , 5 |
heat shock protein, alpha-crystallin-related, B91, 5 |
69.72(n)1
63.4(a)1 |
|
11 (63.54 cM)5
754821 NM_029307.11 NP_083583.11
1007139225 |
ENSEMBL Gene Tree for HSPB9 (if available)
TreeFam Gene Tree for HSPB9 (if available) |
Paralogs
for HSPB9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HSPB9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSPB9 (40274756 - 40275371 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPB9: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB9 |
|
Disorders
/ Diseases
for HSPB9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSPB9 for disorders About GeneDecksing
OMIM gene information: 608344
OMIM disorders: --
2  diseases for HSPB9: About MalaCardsleiomyosarcoma leiomyoma
Export disorders for HSPB9 gene to outside databases
|
Publications
for HSPB9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSPB9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSPB9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. (PubMed id 11470154)1, 2, 3 Kappe G.... de Jong W.W. (2001)
- The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PubMed id 12820654)1, 3, 9 KappAc G....de Jong W.W. (2003)
- HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)1, 2 Vos M.J....Kampinga H.H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. (PubMed id 15503857)1 de Wit N.J....Boelens W.C. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- [Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography] (PubMed id 5503857)1 Tete R....Piante M. (1970)
|
External Searches for HSPB9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSPB9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSPB9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSPB9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSPB9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSPB9 gene:
Search GeneIP for patents involving HSPB9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSPB9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HSPB9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB9 | | | OriGene Protein Over-expression Lysate for HSPB9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSPB9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HSPB9 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HSPB9 | | OriGene Custom Protein Services for HSPB9 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPB9 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB9 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB9 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB9 |
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| | | | Search Tocris compounds for HSPB9 |
| |  |  |  |  | | | | | | Recombinant Protein for HSPB9 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for HSPB9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB9 |
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