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Aliases for HSPB9 Gene

Aliases for HSPB9 Gene

  • Heat Shock Protein, Alpha-Crystallin-Related, B9 2 3
  • Cancer/Testis Antigen 51 2 3 4
  • CT51 3 4
  • Small Heat Shock Protein B9 3
  • HspB9 4

External Ids for HSPB9 Gene

Previous GeneCards Identifiers for HSPB9 Gene

  • GC17P040648
  • GC17P037526
  • GC17P040274
  • GC17P036039

Summaries for HSPB9 Gene

GeneCards Summary for HSPB9 Gene

HSPB9 (Heat Shock Protein, Alpha-Crystallin-Related, B9) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB9 Gene

Genomics for HSPB9 Gene

Regulatory Elements for HSPB9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPB9 Gene

42,121,431 bp from pter
42,123,353 bp from pter
1,923 bases
Plus strand

Genomic View for HSPB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HSPB9 Gene

Proteins for HSPB9 Gene

  • Protein details for HSPB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-9
    Protein Accession:
    Secondary Accessions:
    • B3KSG6
    • Q52LB4

    Protein attributes for HSPB9 Gene

    159 amino acids
    Molecular mass:
    17486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPB9 Gene

Proteomics data for HSPB9 Gene at MOPED

Post-translational modifications for HSPB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPB9 Gene

Domains & Families for HSPB9 Gene

Gene Families for HSPB9 Gene

Protein Domains for HSPB9 Gene

Suggested Antigen Peptide Sequences for HSPB9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB9: view

Function for HSPB9 Gene

Gene Ontology (GO) - Molecular Function for HSPB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15503857
genes like me logo Genes that share ontologies with HSPB9: view

Phenotypes for HSPB9 Gene

GenomeRNAi human phenotypes for HSPB9:
genes like me logo Genes that share phenotypes with HSPB9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB9

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPB9 Gene

Localization for HSPB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB9 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB9 Gene COMPARTMENTS Subcellular localization image for HSPB9 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HSPB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
genes like me logo Genes that share ontologies with HSPB9: view

Pathways & Interactions for HSPB9 Gene

SuperPathways for HSPB9 Gene

No Data Available

Interacting Proteins for HSPB9 Gene

Selected Interacting proteins: Q9BQS6-HSPB9_HUMAN for HSPB9 Gene via I2D UniProtKB

Gene Ontology (GO) - Biological Process for HSPB9 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSPB9 Gene

Drugs & Compounds for HSPB9 Gene

No Compound Related Data Available

Transcripts for HSPB9 Gene

mRNA/cDNA for HSPB9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPB9 Gene

Heat shock protein, alpha-crystallin-related, B9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB9 Gene

No ASD Table

Relevant External Links for HSPB9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB9 Gene

mRNA expression in normal human tissues for HSPB9 Gene

mRNA differential expression in normal tissues according to GTEx for HSPB9 Gene

This gene is overexpressed in Testis (x29.2) and Liver (x5.1).

SOURCE GeneReport for Unigene cluster for HSPB9 Gene Hs.620611

mRNA Expression by UniProt/SwissProt for HSPB9 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with HSPB9: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HSPB9 Gene

Orthologs for HSPB9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HSPB9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB9 35
  • 74.29 (n)
  • 60.13 (a)
(Canis familiaris)
Mammalia HSPB9 35
  • 74.47 (n)
  • 62.66 (a)
(Mus musculus)
Mammalia Hspb9 35
  • 69.5 (n)
  • 63.4 (a)
Hspb9 16
(Pan troglodytes)
Mammalia HSPB9 35
  • 98.74 (n)
  • 97.48 (a)
(Rattus norvegicus)
Mammalia Hspb9 35
  • 71.79 (n)
  • 65.03 (a)
Species with no ortholog for HSPB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSPB9 Gene

Gene Tree for HSPB9 (if available)
Gene Tree for HSPB9 (if available)

Paralogs for HSPB9 Gene

No data available for Paralogs for HSPB9 Gene

Variants for HSPB9 Gene

Sequence variations from dbSNP and Humsavar for HSPB9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12453044 -- 42,123,541(+) aaaac(A/C)caaaa downstream-variant-500B
VAR_022054 -

Structural Variations from Database of Genomic Variants (DGV) for HSPB9 Gene

Variant ID Type Subtype PubMed ID
nsv908241 CNV Loss 21882294
dgv3169n71 CNV Loss 21882294

Variation tolerance for HSPB9 Gene

Residual Variation Intolerance Score: 78.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.24; 84.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB9 Gene

Disorders for HSPB9 Gene

Relevant External Links for HSPB9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPB9 Gene

Publications for HSPB9 Gene

  1. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PMID: 12820654) KappAc G. … de Jong W.W. (Cell Stress Chaperones 2003) 2 23 67
  2. Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. (PMID: 11470154) Kappe G. … de Jong W.W. (Biochim. Biophys. Acta 2001) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos M.J. … Kampinga H.H. (Biochim. Biophys. Acta 2009) 67
  5. Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. (PMID: 15503857) de Wit N.J. … Boelens W.C. (Eur. J. Cell Biol. 2004) 67

Products for HSPB9 Gene

Sources for HSPB9 Gene

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