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HSPB8 Gene

protein-coding GIFtS: 59

GC12P118079

heat shock 22kDa protein 8
(Previous name: heat shock 27kDa protein 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CMT2L ^², ⁵
CRYAC ^³
DHMN2 ^², ⁵
E2IG1 ^¹, ², ³, ⁵
H11 ^¹, ², ⁵
HMN2 ^²
HMN2A ^², ⁵
HSP22 ^¹, ², ³
HspB8 ^¹, ³

Descriptions
Alpha-crystallin C chain ^³
E2-induced gene 1 ^²
E2-induced gene 1 protein ^³
Protein kinase H11 ^², ³
Small stress protein-like protein HSP22 ^², ³
heat shock 22kDa protein 8 ^²
heat shock 27kDa protein 8 ^¹, ²
heat shock protein beta-8 ^²

External Ids
HGNC: 30171¹
Entrez Gene: 26353²
UniProtKB: Q9UJY1³
Ensembl: ENSG00000152137⁷

Search outside databases for aliases for HSPB8 gene

Previous GC identifer: GC12P118028

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HSPB8:

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing

a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of

this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this

protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy.

Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and

carcinogenesis, and mutations in this gene have been associated with different neuromuscular

diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1

Function: Displays temperature-dependent chaperone activity

Gene Wiki entry for HSPB8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HSPB8 gene

Entrez Gene cytogenetic band: 12q24.23 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.23

HSPB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P118079: (about GC identifiers)

Start:	118,100,978 bp from pter
End:	118,116,934 bp from pter
Size:	15,957 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1 (See protein sequence)

Recommended Name: Heat shock protein beta-8

Size: 196 amino acids; 21604 Da

Subunit: Monomer. Interacts with HSPB1

Caution: Was reported (PubMed:10833516) to have a protein kinase activity and to act as a

Mn(2+)-dependent serine-threonine-specific protein kinase

Secondary accessions: Q6FIH3 Q9UKS3

Post-translational modifications:

Phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055180.1

ENSEMBL proteins:

ENSP00000281938

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hsp22)
	Human Recombinant Proteins from Abnova (HSPB8)

OriGene Purified Recombinant Human Protein: HSPB8

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IDA	11256614

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Antibodies for HSPB8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HSPB8
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for HSPB8 (HSPB8/HSP22)
	Antibodies from Abcam (Hsp22), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HSPB8)
	Novus Biologicals Antibodies for HSPB8

Assays for HSPB8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UJY1

ProtoNet protein and cluster: Q9UJY1

1 Blocks protein family: IPB002068 Heat shock protein Hsp20

UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1

Similarity: Belongs to the small heat shock protein (HSP20) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSPB8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HSPB8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014365

Applied Biosystems Silencer® siRNAs for HSPB8

Sigma-Aldrich siRNA and siRNA Panels for HSPB8

Sigma-Aldrich shRNA Panels and shRNA for HSPB8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HSPB8
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014365
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014365
untagged cDNA clone in CMV expression vector: NM_014365

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014365

UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1

Function: Displays temperature-dependent chaperone activity

Induction: By 17-beta-estradiol

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	NAS	10833516
GO:0042802	identical protein binding	IPI	14594798

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for HSPB8 (Your Favorite Gene powered by Ingenuity)

NRF2-mediated Oxidative Stress Response

GeneDecks HSPB8 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HSPB8

5/29 Interacting proteins for HSPB8 (ENSP00000281938³ Q9UJY1^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPB1	P04792¹	STRING (score=.961) EBI-739074, EBI-352682
HSPB2	Q16082¹	STRING (score=.894) EBI-739074, EBI-739395
HSPB7	Q9UBY9¹	STRING (score=.858) EBI-739074, EBI-739361
CRYAB	P02511¹	EBI-739074, EBI-739060
HSPB6	O14558¹	EBI-739074, EBI-739095

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0009408	response to heat	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HSPB8
1 Novoseek chemical compound relationship for HSPB8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	18.09	1	15543936 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSPB8)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HSPB8)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014365

Sigma-Aldrich siRNA and siRNA Panels for HSPB8

Sigma-Aldrich shRNA Panels and shRNA for HSPB8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014365

REFSEQ mRNAs for HSPB8 gene:

NM_014365.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014365

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014365
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014365
                                 untagged cDNA clone in CMV expression vector: NM_014365

Additional cDNA sequence:

AF133207.1 AF191017.1 AF217987.1 AF250138.1 AK312501.1 AL136936.1 BC002673.2 BT006876.1

CR533453.1 CR590762.1 CR591785.1 CR594671.1 CR597922.1 CR599692.1 CR604459.1 CR607849.1

CR608992.1 CR611633.1 CR611944.1 CR612820.1 CR613252.1 CR614248.1 CR614666.1 CR616260.1

CR617456.1 CR621727.1

11 DOTS entries:

DT.118507 DT.97805038 DT.100790665 DT.100791064 DT.95315897 DT.91771456 DT.95127280 DT.95315892

DT.121194272 DT.95315932 DT.40290479

24/347 AceView cDNA sequences (see all 347 ):

BQ576167 BX396664 CA397786 BQ101004 CR608992 NM_014365 BX396684 BM817930

AA364235 CR614248 CR611944 AI356117 BX397219 BP374630 CR616260 BM726040

BX396468 CR621727 BM704580 AA970409 AL136936 BM682477 CR604459 BU631212

highest scoring ESTs for HSPB8:

AA010110 AA147248 AA301673 AA364235 AA364454 AA369616 AA524362 AA526710 AA679011 AA705026

Unigene Cluster for HSPB8:

Heat shock 22kDa protein 8

Hs.400095 [show with all ESTs]

Unigene Representative Sequence: NM_014365

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000281938

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HSPB8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HSPB8

¹ / ² / ³

6 probe-sets matching HSPB8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56474_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.38	W23068	0.60	1.00	0.82	1
70345_at²^{, 3}	U95-E	1	1.00	1.00	0.77	0.63	AI740733	0.80	1.00	0.91	1
221667_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF133207	0.80	1.00	0.91	1
233057_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF109740	0.60	1.00	0.82	1
221667_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233057_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTGGTTGTG

SOURCE GeneReport for Unigene cluster: Hs.400095
UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1
Tissue specificity: Predominantly expressed in skeletal muscle and heart

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSPB8 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HSPB8¹	--	heat shock 22kDa protein 8	90.31(n) 93.88(a)	403553 NM_001003029.1 NP_001003029.1
chimpanzee (Pan troglodytes)	HSPB8¹	--	heat shock 22kDa protein 8	99.66(n) 100(a)	452295 XM_509417.2 XP_509417.1
cow (Bos taurus)	HSPB8¹	--	heat shock 22kDa protein 8	90.48(n) 95.92(a)	539524 NM_001014955.1 NP_001014955.1
rat (Rattus norvegicus)	Hspb8¹	--	heat shock protein 8	88.61(n) 95.41(a)	113906 NM_053612.2 NP_446064.1
mouse (Mus musculus)	Hspb8^{1, 5}	5 (59.00 cM)⁵	heat shock protein 8^{1, 5}	87.24(n)¹ 94.39(a)¹	80888¹ NM_030704.2¹ NP_109629.1¹ AA000077⁵ AF250139⁵ (see all 20)

About this table Species with no ortholog for HSPB8

ENSEMBL Gene Tree for HSPB8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HSPB8 gene

HSPB2² HSPB3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/118 NCBI SNPs in HSPB8 are shown (see all 118 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 49)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1133026^1,2	A,C,F,H	118116730(+)	`AAGTCG/AGGATT`	1	--	ut3¹		17		MN CSAM EA EU WA NA	1572
	rs11038^1,2	A,C,F,H	118116690(+)	`ATCTGA/GCCTAG`	1	--	ut3¹ ese³		18		MN CSAM EA NA EU WA	1696
	rs11064704^1,2	C,F,H	118117096(+)	`GAGCCC/TTGAGG`	1	--	ng3¹		8		EU EA WA	838
	rs6413487^1,2	C,F,H	118116662(+)	`AAGGAC/GGCTGG`	1	--	ut3¹ ese³		12		MN CSAM EA EU WA NA	956
	rs13378054^1,2	F,H	118116486(+)	`AAACCC/GAGTAG`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs2727726^1,2	A,C	118100610(+)	`AAAAAA/TTTTTT`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs10849632^1,2	A	118099340(+)	`CTCCAA/GGCCAA`	1	--	ng5¹		0	--	--	--	--
	rs36008907^1,2	C	118116040(+)	`ACCTGT/AACCTG`	1	X/C	non¹		4		EU EA WA	420
	rs4628742^1,2	C,F,H	118116037(+)	`GTCACC/TTGTAC`	1	T/T	syn¹ ese³		4		EU EA WA	420
	rs12811848^1,2	A,C,F,H	118104015(+)	`gtaagG/Agtgta`	1	--	int¹		4		EU EA WA	402

About this table

HapMap Linkage Disequilibrium images for HSPB8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608014 disorders: 158590 608673

UniProtKB/Swiss-Prot: HSPB8_HUMAN, Q9UJY1

Defects in HSPB8 are the cause of distal hereditary motor neuronopathy type 2A (HMN2A)

[MIM:158590]; also known as distal hereditary motor neuropathy type IIA or spinal

Charcot-Marie-Tooth disease IIA. Distal hereditary motor neuronopathies constitute a heterogeneous

group of neuromuscular disorders caused by selective impairment of motor neurons in the anterior

horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical

picture consists of a classical distal muscular atrophy syndrome in the legs without clinical

sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior

tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the

proximal muscles of the lower limbs and/or to the distal upper limbs

Defects in HSPB8 are the cause of Charcot-Marie-Tooth disease type 2L (CMT2L)

[MIM:608673]. CMT2L is an axonal form of Charcot-Marie-Tooth disease. Axonal CMT neuropathies are

characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal

or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and

atrophy

5 Novoseek disease relationships for HSPB8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	68.34	40	17922839 (3), 14985082 (3), 15541337 (2), 18298377 (1) (see all 15)
neuromuscular diseases	62.62	4	15879436 (1), 16949546 (1)
cardiac hypertrophy	49.47	3	15541337 (1)
alzheimers disease	28.96	1	16485107 (1)
ischemia	0.00	1	16373598 (1)

About this table

GeneTests: HSPB8

Charcot-Marie-Tooth Neuropathy Type 2

Human Gene Mutation Database: HSPB8
Human Genome Epidemiology Navigator: HSPB8 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/72 PubMed articles for HSPB8 gene (see all 72 ):

A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. (PubMed id 10833516)^{1, 2, 3, 4} Smith C.C.... Aurelian L. (2000)
Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PubMed id 11085516)^{2, 3, 4} Charpentier A.H....Aldaz C.M. (2000)
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. (PubMed id 15122253)^{1, 3, 4} Irobi J.... Timmerman V. (2004)
Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. (PubMed id 11470154)^{1, 3, 4} Kappe G.... de Jong W.W. (2001)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27). (PubMed id 11342557)^{3, 4} Benndorf R.... Welsh M.J. (2001)
Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry. (PubMed id 11816564)^{3, 4} Molloy M.P. and Andrews P.C. (2001)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells. (PubMed id 18229450)^{1, 3} Sun X....Benndorf R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26353	HGNC: 30171	AceView: HSPB8	Ensembl:ENSG00000152137	euGenes: HUgn26353
ECgene: HSPB8	H-InvDB: HSPB8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Inherited peripheral neuropathies mutation db	http://www.molgen.ua.ac.be/CMTMutations/
GeneReviews	http://www.genetests.org/query?gene=HSPB8

Licensable Technologies for HSPB8
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HSPB8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HSPB8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HSPB8		Antibodies for HSPB8
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HSPB8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HSPB8)
	Antibodies (HSPB8)
	Chimera RNAi (HSPB8)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for HSPB8 (HSPB8/HSP22)

	Recombinant Proteins (Hsp22)
	Antibodies (Hsp22)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for HSPB8

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HSPB8

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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HSPB8 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for HSPB8

Summaries
for HSPB8

Genomic Location
for HSPB8

Proteins
for HSPB8

Protein Domains/
Families
for HSPB8

Gene Function
for HSPB8

Pathways & Interactions
for HSPB8

Drugs & Compounds
for HSPB8

Transcripts
for HSPB8

Expression
for HSPB8

Orthologs
for HSPB8

Paralogs
for HSPB8

SNPs/Variants
for HSPB8

Disorders & Mutations
for HSPB8

Medical News
for HSPB8

Publications
for HSPB8

Search for HSPB8

Genome Databases showing HSPB8

Other Databases showing HSPB8

Specialized Databases showing HSPB8

Licensable Technologies
for HSPB8

Services
for HSPB8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HSPB8 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor HSPB8

Summariesfor HSPB8

Genomic Locationfor HSPB8

Proteinsfor HSPB8

Protein Domains/Familiesfor HSPB8

Gene Functionfor HSPB8

Pathways & Interactionsfor HSPB8

Drugs & Compoundsfor HSPB8

Transcriptsfor HSPB8

Expression for HSPB8

Orthologsfor HSPB8

Paralogsfor HSPB8

SNPs/Variantsfor HSPB8

Disorders & Mutationsfor HSPB8

Medical Newsfor HSPB8

Publicationsfor HSPB8

Search for HSPB8

Genome Databases showing HSPB8

Other Databases showing HSPB8

Specialized Databases showing HSPB8

Licensable Technologiesfor HSPB8

Servicesfor HSPB8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HSPB8

Summaries
for HSPB8

Genomic Location
for HSPB8

Proteins
for HSPB8

Protein Domains/
Families
for HSPB8

Gene Function
for HSPB8

Pathways & Interactions
for HSPB8

Drugs & Compounds
for HSPB8

Transcripts
for HSPB8

Expression
for HSPB8

Orthologs
for HSPB8

Paralogs
for HSPB8

SNPs/Variants
for HSPB8

Disorders & Mutations
for HSPB8

Medical News
for HSPB8

Publications
for HSPB8

Licensable Technologies
for HSPB8

Services
for HSPB8