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Aliases for HSPB7 Gene

Aliases for HSPB7 Gene

  • Heat Shock Protein Family B (Small) Member 7 2 3 5
  • Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular) 2 3
  • Heat Shock 27kD Protein Family, Member 7 (Cardiovascular) 2 3
  • Cardiovascular Heat Shock Protein 3 4
  • CvHSP 3 4
  • Heat Shock 27kDa Protein Family Member 7 (Cardiovascular) 3
  • HspB7 4

External Ids for HSPB7 Gene

Previous GeneCards Identifiers for HSPB7 Gene

  • GC01M015737
  • GC01M015519
  • GC01M9E0029
  • GC01M015703
  • GC01M016085
  • GC01M016213
  • GC01M016340
  • GC01M014859

Summaries for HSPB7 Gene

GeneCards Summary for HSPB7 Gene

HSPB7 (Heat Shock Protein Family B (Small) Member 7) is a Protein Coding gene. Diseases associated with HSPB7 include Systolic Heart Failure. GO annotations related to this gene include protein C-terminus binding and filamin binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB7 Gene

Genomics for HSPB7 Gene

Regulatory Elements for HSPB7 Gene

Enhancers for HSPB7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPB7 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPB7 Gene

16,014,028 bp from pter
16,019,594 bp from pter
5,567 bases
Minus strand

Genomic View for HSPB7 Gene

Genes around HSPB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB7 Gene

Proteins for HSPB7 Gene

  • Protein details for HSPB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-7
    Protein Accession:
    Secondary Accessions:
    • B3KQ37
    • C9K0Y0
    • Q9NU17

    Protein attributes for HSPB7 Gene

    170 amino acids
    Molecular mass:
    18611 Da
    Quaternary structure:
    • Interacts with C-terminal domain of actin-binding protein 280.

    Alternative splice isoforms for HSPB7 Gene


neXtProt entry for HSPB7 Gene

Proteomics data for HSPB7 Gene at MOPED

Post-translational modifications for HSPB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB7 Gene

No data available for DME Specific Peptides for HSPB7 Gene

Domains & Families for HSPB7 Gene

Gene Families for HSPB7 Gene

Protein Domains for HSPB7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB7: view

Function for HSPB7 Gene

Molecular function for HSPB7 Gene

GENATLAS Biochemistry:
heat shock protein 7,highly expressed in heart,also expressed in skeletal muscle and at low levels in aorta and adipose tissues,interacting with alpha filamin,potentially involved in chaperone activity and maintenance of cytoskeletal network in muscle,alpha criltallin/small hsp family

Phenotypes for HSPB7 Gene

GenomeRNAi human phenotypes for HSPB7:
genes like me logo Genes that share phenotypes with HSPB7: view

Animal Model Products

miRNA for HSPB7 Gene

miRTarBase miRNAs that target HSPB7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPB7 Gene

Localization for HSPB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB7 Gene

Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Subcellular locations from

Jensen Localization Image for HSPB7 Gene COMPARTMENTS Subcellular localization image for HSPB7 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for HSPB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
GO:0005739 mitochondrion IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSPB7: view

Pathways & Interactions for HSPB7 Gene

SuperPathways for HSPB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPB7 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSPB7 Gene

Drugs & Compounds for HSPB7 Gene

No Compound Related Data Available

Transcripts for HSPB7 Gene

Unigene Clusters for HSPB7 Gene

Heat shock 27kDa protein family, member 7 (cardiovascular):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i · 4j
SP1: - - -
SP2: -
SP4: -
SP6: - -
SP7: - -
SP8: - -
SP9: -

Relevant External Links for HSPB7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB7 Gene

mRNA expression in normal human tissues for HSPB7 Gene

mRNA differential expression in normal tissues according to GTEx for HSPB7 Gene

This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x8.6), and Heart - Atrial Appendage (x7.7).

Protein differential expression in normal tissues from HIPED for HSPB7 Gene

This gene is overexpressed in Heart (13.1), Fetal heart (12.3), Cardia (9.2), and Prostate (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB7 Gene

SOURCE GeneReport for Unigene cluster for HSPB7 Gene Hs.502612

mRNA Expression by UniProt/SwissProt for HSPB7 Gene

Tissue specificity: Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
genes like me logo Genes that share expression patterns with HSPB7: view

Protein tissue co-expression partners for HSPB7 Gene

- Elite partner

Primer Products

Orthologs for HSPB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB7 35
  • 88.48 (n)
  • 92.12 (a)
HSPB7 36
  • 82 (a)
(Canis familiaris)
Mammalia HSPB7 35
  • 90.39 (n)
  • 97.06 (a)
HSPB7 36
  • 67 (a)
(Mus musculus)
Mammalia Hspb7 35
  • 86.79 (n)
  • 94.08 (a)
Hspb7 16
Hspb7 36
  • 95 (a)
(Pan troglodytes)
Mammalia HSPB7 35
  • 98.82 (n)
  • 100 (a)
HSPB7 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Hspb7 35
  • 87.57 (n)
  • 93.49 (a)
(Monodelphis domestica)
Mammalia HSPB7 36
  • 84 (a)
(Gallus gallus)
Aves HSPB7 35
  • 77.12 (n)
  • 77.97 (a)
HSPB7 36
  • 72 (a)
(Anolis carolinensis)
Reptilia HSPB7 36
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2603 35
(Danio rerio)
Actinopterygii hspb7 35
  • 65.42 (n)
  • 66.46 (a)
hspb7 36
  • 70 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for HSPB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB7 Gene

Gene Tree for HSPB7 (if available)
Gene Tree for HSPB7 (if available)

Paralogs for HSPB7 Gene

(2) SIMAP similar genes for HSPB7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSPB7: view

No data available for Paralogs for HSPB7 Gene

Variants for HSPB7 Gene

Sequence variations from dbSNP and Humsavar for HSPB7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11556 -- 16,014,170(+) ATGGA(G/T)GGAGG utr-variant-3-prime
rs15399 -- 16,014,109(-) GGCCC(A/C)TTGGG utr-variant-3-prime
rs732286 -- 16,017,865(+) GGGAG(A/G)GCACG reference, synonymous-codon
rs761759 -- 16,015,855(+) GCCAG(A/T)CCCCA intron-variant
rs761760 -- 16,015,924(+) AGGCC(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB7 Gene

Variant ID Type Subtype PubMed ID
nsv871162 CNV Gain 21882294
nsv508936 CNV Insertion 20534489
dgv174n71 CNV Loss 21882294
nsv833758 CNV Gain+Loss 17160897
nsv871695 CNV Loss 21882294
nsv517651 CNV Gain+Loss 19592680
dgv175n71 CNV Gain 21882294
dgv176n71 CNV Loss 21882294
nsv520148 CNV Loss 19592680
nsv871485 CNV Loss 21882294
nsv524045 CNV Loss 19592680
dgv12n27 CNV Loss 19166990
nsv460629 CNV Gain 19166990
nsv470698 CNV Loss 18288195

Variation tolerance for HSPB7 Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB7 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB7 Gene

Disorders for HSPB7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPB7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systolic heart failure
  • heart failure, systolic
- elite association - COSMIC cancer census association via MalaCards
Search HSPB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPB7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB7 Gene

Publications for HSPB7 Gene

  1. Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin- sensitive tissues. (PMID: 10593960) Krief S. … Bril A. (J. Biol. Chem. 1999) 2 3 4 67
  2. Involvement of BAG3 and HSPB7 loci in various etiologies of systolic heart failure: Results of a European collaboration assembling more than 2000 patients. (PMID: 25889438) Garnier S. … Charron P. (Int. J. Cardiol. 2015) 3
  3. Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation. (PMID: 24585183) Lin J. … Nakamura Y. (Int. J. Oncol. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome. (PMID: 22785082) Chiu T.F. … Yang R.B. (Circ. J. 2012) 3

Products for HSPB7 Gene

Sources for HSPB7 Gene