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Aliases for HSPB7 Gene

Aliases for HSPB7 Gene

  • Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular) 2 3
  • CvHSP 3 4 6
  • Heat Shock 27kD Protein Family, Member 7 (Cardiovascular) 2 3
  • Cardiovascular Heat Shock Protein 3 4
  • Heat Shock Protein Beta-7 3
  • HspB7 4

External Ids for HSPB7 Gene

Summaries for HSPB7 Gene

GeneCards Summary for HSPB7 Gene

HSPB7 (Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular)) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB7 Gene

Genomics for HSPB7 Gene

Genomic Location for HSPB7 Gene

Start:
16,014,028 bp from pter
End:
16,019,594 bp from pter
Size:
5,567 bases
Orientation:
Minus strand

Genomic View for HSPB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB7 Gene

Regulatory Elements for HSPB7 Gene

Proteins for HSPB7 Gene

  • Protein details for HSPB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBY9-HSPB7_HUMAN
    Recommended name:
    Heat shock protein beta-7
    Protein Accession:
    Q9UBY9
    Secondary Accessions:
    • B3KQ37
    • C9K0Y0
    • Q9NU17

    Protein attributes for HSPB7 Gene

    Size:
    170 amino acids
    Molecular mass:
    18611 Da
    Quaternary structure:
    • Interacts with C-terminal domain of actin-binding protein 280

    Alternative splice isoforms for HSPB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPB7 Gene

Proteomics data for HSPB7 Gene at MOPED

Post-translational modifications for HSPB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB7 Gene

No data available for DME Specific Peptides for HSPB7 Gene

Domains for HSPB7 Gene

Gene Families for HSPB7 Gene

HGNC:
  • HSPB :Heat shock proteins / HSPB

Protein Domains for HSPB7 Gene

UniProtKB/Swiss-Prot:

HSPB7_HUMAN
Family:
  • Belongs to the small heat shock protein (HSP20) family.:
    • Q9UBY9
genes like me logo Genes that share domains with HSPB7: view

Function for HSPB7 Gene

Molecular function for HSPB7 Gene

GENATLAS Biochemistry: heat shock protein 7,highly expressed in heart,also expressed in skeletal muscle and at low levels in aorta and adipose tissues,interacting with alpha filamin,potentially involved in chaperone activity and maintenance of cytoskeletal network in muscle,alpha criltallin/small hsp family

Gene Ontology (GO) - Molecular Function for HSPB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14594798
GO:0008022 protein C-terminus binding TAS 10593960
GO:0031005 filamin binding IEA --
genes like me logo Genes that share ontologies with HSPB7: view

Phenotypes for HSPB7 Gene

GenomeRNAi human phenotypes for HSPB7:
genes like me logo Genes that share phenotypes with HSPB7: view

miRNA for HSPB7 Gene

miRTarBase miRNAs that target HSPB7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPB7 Gene

Localization for HSPB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB7 Gene

Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPB7 Gene COMPARTMENTS Subcellular localization image for HSPB7 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HSPB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
GO:0005739 mitochondrion IEA --
GO:0015030 Cajal body IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSPB7: view

Pathways for HSPB7 Gene

SuperPathways for HSPB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0006986 response to unfolded protein TAS 10593960
GO:0008016 regulation of heart contraction TAS 10593960
genes like me logo Genes that share ontologies with HSPB7: view

No data available for Pathways by source for HSPB7 Gene

Transcripts for HSPB7 Gene

Unigene Clusters for HSPB7 Gene

Heat shock 27kDa protein family, member 7 (cardiovascular):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i · 4j
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6: - -
SP7: - -
SP8: - -
SP9: -
SP10:

Relevant External Links for HSPB7 Gene

GeneLoc Exon Structure for
HSPB7
ECgene alternative splicing isoforms for
HSPB7

Expression for HSPB7 Gene

mRNA expression in normal human tissues for HSPB7 Gene

mRNA differential expression in normal tissues according to GTEx for HSPB7 Gene

This gene is overexpressed in Heart - Left Ventricle (20.3), Muscle - Skeletal (8.6), and Heart - Atrial Appendage (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB7 Gene

SOURCE GeneReport for Unigene cluster for HSPB7 Gene Hs.502612

mRNA Expression by UniProt/SwissProt for HSPB7 Gene

Q9UBY9-HSPB7_HUMAN
Tissue specificity: Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart
genes like me logo Genes that share expressions with HSPB7: view

Orthologs for HSPB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPB7 36
  • 98.82 (n)
  • 100 (a)
HSPB7 37
  • 65 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPB7 36
  • 88.48 (n)
  • 92.12 (a)
HSPB7 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPB7 36
  • 90.39 (n)
  • 97.06 (a)
HSPB7 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspb7 36
  • 86.79 (n)
  • 94.08 (a)
Hspb7 16
Hspb7 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPB7 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspb7 36
  • 87.57 (n)
  • 93.49 (a)
chicken
(Gallus gallus)
Aves HSPB7 36
  • 77.12 (n)
  • 77.97 (a)
HSPB7 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPB7 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2603 36
zebrafish
(Danio rerio)
Actinopterygii hspb7 36
  • 65.42 (n)
  • 66.46 (a)
hspb7 37
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToOne
Species with no ortholog for HSPB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB7 Gene

ENSEMBL:
Gene Tree for HSPB7 (if available)
TreeFam:
Gene Tree for HSPB7 (if available)

Paralogs for HSPB7 Gene

Selected SIMAP similar genes for HSPB7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSPB7: view

No data available for Paralogs for HSPB7 Gene

Variants for HSPB7 Gene

Sequence variations from dbSNP and Humsavar for HSPB7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11556 -- 16,014,170(+) ATGGA(G/T)GGAGG utr-variant-3-prime
rs15399 -- 16,014,109(-) GGCCC(A/C)TTGGG utr-variant-3-prime
rs732286 -- 16,017,865(+) GGGAG(A/G)GCACG synonymous-codon, reference
rs761759 -- 16,015,855(+) GCCAG(A/T)CCCCA intron-variant
rs761760 -- 16,015,924(+) AGGCC(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB7 Gene

Variant ID Type Subtype PubMed ID
nsv871162 CNV Gain 21882294
nsv508936 CNV Insertion 20534489
dgv174n71 CNV Loss 21882294
nsv833758 CNV Gain+Loss 17160897
nsv871695 CNV Loss 21882294
nsv517651 CNV Gain+Loss 19592680
dgv175n71 CNV Gain 21882294
dgv176n71 CNV Loss 21882294
nsv520148 CNV Loss 19592680
nsv871485 CNV Loss 21882294
nsv524045 CNV Loss 19592680
dgv12n27 CNV Loss 19166990
nsv460629 CNV Gain 19166990
nsv470698 CNV Loss 18288195

Relevant External Links for HSPB7 Gene

HapMap Linkage Disequilibrium report
HSPB7
Human Gene Mutation Database (HGMD)
HSPB7

Disorders for HSPB7 Gene

Relevant External Links for HSPB7

Genetic Association Database (GAD)
HSPB7
Human Genome Epidemiology (HuGE) Navigator
HSPB7
genes like me logo Genes that share disorders with HSPB7: view

No data available for UniProtKB/Swiss-Prot for HSPB7 Gene

Publications for HSPB7 Gene

  1. Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin- sensitive tissues. (PMID: 10593960) Krief S. … Bril A. (J. Biol. Chem. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos M.J. … Kampinga H.H. (Biochim. Biophys. Acta 2009) 3 4

Products for HSPB7 Gene

Sources for HSPB7 Gene

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