Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPB7 Gene

protein-coding   GIFtS: 54
GCID: GC01M016340

heat shock 27kDa protein family, member 7 (cardiovascular)

(Previous names: heat shock 27kD protein family, member 7 (cardiovascular)...)
 Explore 4 diseases affiliated with
HSPB7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSPB7    

Aliases
for HSPB7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock 27kDa Protein Family, Member 7 (Cardiovascular)1 2     CVHSP3 5
CvHSP1     Heat Shock Protein Beta-72
Heat Shock 27kD Protein Family, Member 7 (Cardiovascular)1 2     HspB73
Cardiovascular Heat Shock Protein2 3     CvHsp1

External Ids:    HGNC: 52491   Entrez Gene: 271292   Ensembl: ENSG000001736417   OMIM: 6106925   UniProtKB: Q9UBY93   

Export aliases for HSPB7 gene to outside databases

Previous GC identifers: GC01M015737 GC01M015519 GC01M9E0029 GC01M015703 GC01M016085 GC01M016213 GC01M014859


Summaries
for HSPB7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for HSPB7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPB7 gene promoter:
         SRF   USF1   SRF (504 AA)   Nkx2-5   E47   HEN1   PPAR-gamma1   USF-1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPB7 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPB7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23-p34.3   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.23-p34.3

HSPB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M016340:  view genomic region     (about GC identifiers)

Start:
 16,340,523 bp from pter      End:
 16,346,089 bp from pter
Size:
 5,567 bases      Orientation:
 minus strand

Proteins
for HSPB7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HSPB7_HUMAN, Q9UBY9 (See protein sequence)
Recommended Name: Heat shock protein beta-7  
Size: 170 amino acids; 18611 Da
Subunit: Interacts with C-terminal domain of actin-binding protein 280
Subcellular location: Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35
speckles or nuclear splicing speckles
Secondary accessions: B3KQ37 C9K0Y0 Q9NU17
Alternative splicing: 3 isoforms:  Q9UBY9-1   Q9UBY9-2   Q9UBY9-3   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for HSPB7: NX_Q9UBY9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBY9

    • HSPB7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055239.1  
    ENSEMBL proteins: 
     ENSP00000391578   ENSP00000310111   ENSP00000364870   ENSP00000417966   ENSP00000419477  
     ENSP00000385472   ENSP00000445013  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HSPB7
    OriGene Protein Over-expression Lysate: HSPB7
    OriGene Custom Protein Services for HSPB7 
    GenScript Custom Purified and Recombinant Proteins Services for HSPB7
    Novus Biologicals HSPB7 Proteins
    Novus Biologicals HSPB7 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HSPB7
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19464326
    GO:0005737cytoplasm IDA19464326
    GO:0005739mitochondrion IEA--
    GO:0015030Cajal body IEA--


    HSPB7 for ontologies           About GeneDecksing



    HSPB7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: HSPB7
    OriGene Custom Antibody Services for HSPB7 
    GenScript Custom Superior Antibodies Services for HSPB7
    Novus Biologicals HSPB7 Antibodies
    Abcam antibodies for HSPB7 
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for HSPB7

    Assay Products for HSPB7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPB7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HSPB7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSPB7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002068 a-crystallin/Hsp20_dom
     IPR008978 HSP20-like_chaperone
     IPR001436 Alpha-crystallin/HSP

    Graphical View of Domain Structure for InterPro Entry Q9UBY9

    ProtoNet protein and cluster: Q9UBY9

    1 Blocks protein family: IPB002068 Heat shock protein Hsp20

    UniProtKB/Swiss-Prot: HSPB7_HUMAN, Q9UBY9
    Similarity: Belongs to the small heat shock protein (HSP20) family


    Function
    for HSPB7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for HSPB7:
    heat shock protein 7,highly expressed in heart,also expressed in skeletal muscle and at low levels in aorta and adipose
    tissues,interacting with alpha filamin,potentially involved in chaperone activity and maintenance of cytoskeletal
    network in muscle,alpha criltallin/small hsp family

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPB7 (see all 10):
    hsa-miR-615-5p hsa-miR-548d-3p hsa-miR-146b-3p hsa-miR-548s hsa-miR-320e hsa-miR-143 hsa-miR-1207-3p hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmid: HSPB7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB7 (see all 7)
    OriGene shRNA RFP: HSPB7
    OriGene siRNA: HSPB7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSPB7

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HSPB7 (NM_014424)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB7 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HSPB7
    Search LifeMap BioReagents cell lines for HSPB7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB7

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008022protein C-terminus binding TAS10593960


    HSPB7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HSPB7:
     Decreased POU5F1-GFP protein e 


    Pathways & Interactions
    for HSPB7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPB7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HSPB7 (Q9UBY91, 3 ENSP000003101114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB8Q9UJY11, 3, ENSP000002819384EBI-739361,EBI-739074 I2D: score=3 STRING: ENSP00000281938
    KTI12ENSP000003606764STRING: ENSP00000360676
    NRD1ENSP000003468904STRING: ENSP00000346890
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress ----
    GO:0006986response to unfolded protein TAS10593960
    GO:0008016regulation of heart contraction TAS10593960
    GO:0009408response to heat ----


    HSPB7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSPB7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPB7
    Search CenterWatch for drugs/clinical trials and news about HSPB7 

    Transcripts
    for HSPB7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSPB7 gene: 
    NM_014424.4  

    Unigene Cluster for HSPB7:

    Heat shock 27kDa protein family, member 7 (cardiovascular)
    Hs.502612  [show with all ESTs]
    Unigene Representative Sequence: NM_014424
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411503 ENST00000442459 ENST00000311890(uc001axo.2 uc001axp.2 uc001axq.2 uc001axr.2)
    ENST00000375718(uc001axs.2) ENST00000463576 ENST00000487046 ENST00000406363
    ENST00000545268

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPB7 (see all 10):
    hsa-miR-615-5p hsa-miR-548d-3p hsa-miR-146b-3p hsa-miR-548s hsa-miR-320e hsa-miR-143 hsa-miR-1207-3p hsa-miR-4276
    SwitchGear 3'UTR luciferase reporter plasmid: HSPB7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB7 (see all 7)
    OriGene shRNA RFP: HSPB7
    OriGene siRNA: HSPB7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB7
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HSPB7 (NM_014424)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB7 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB7

    Additional cDNA sequence: 

    AF155908.1 AJ243191.1 AK057295.1 AK075151.1 AK092275.1 AK095911.1 AK296598.1 AL832181.1 
    BC006319.2 BX537990.1 CR749298.1 CR749419.1 

    21 DOTS entries:

    DT.99934771  DT.218265  DT.100786570  DT.100786572  DT.97765030  DT.40129503  DT.40305217  DT.121415000 
    DT.75103990  DT.121414998  DT.95201047  DT.95201050  DT.99957297  DT.121415002  DT.121415182  DT.121415197 
    DT.91721953  DT.91752336  DT.95201045  DT.95201019  DT.95238349 

    24/258 AceView cDNA sequences (see all 258):

    CA424992 CB267751 AI828028 AL694275 CF552429 C04451 AI479356 AA723983 
    BQ637483 CB267862 AI334158 BC006319 AI038119 AK057295 BV203382 BI838389 
    BM926609 BX537990 CR749298 AL601175 AI087075 AI185527 AK095911 AI291724 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HSPB7 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g · 4h · 4i · 4j
    SP1:        -     -                 -                                                                                 
    SP2:                                -                                                                                 
    SP3:                                                                                                                  
    SP4:                                                  -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for HSPB7

    Expression
    for HSPB7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPB7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCTCTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HSPB7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage
    HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)Bone
    HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage

    See HSPB7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPB7

    SOURCE GeneReport for Unigene cluster: Hs.502612

    UniProtKB/Swiss-Prot: HSPB7_HUMAN, Q9UBY9
    Tissue specificity: Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels
    in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB7: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB7
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB7

    Orthologs
    for HSPB7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HSPB7 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hspb71 , 5 heat shock protein family, member 7 (cardiovascular)1, 5 87.77(n)1
    95.86(a)1    		   4 (74.08 cM)5
    298181  NM_013868.41  NP_038896.21 
     1414207795 
    chicken
    (Gallus gallus)    		 Aves HSPB71 heat shock 27kDa protein family, member 7 (cardiovascular) 73.42(n)
    72.97(a)    		   430280  XM_427836.3  XP_427836.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HSPB76
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343609.1(348103-351257)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.26032 Xenopus laevis transcribed sequence with weak similarity more 74.06(n)    BG371242.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hspb71 heat shock protein family, alpha-crystallin-related, more 65.84(n)
    67.08(a)    		   450019  NM_001006040.1  NP_001006040.1 


    ENSEMBL Gene Tree for HSPB7 (if available)
    TreeFam Gene Tree for HSPB7 (if available) 

    Paralogs
    for HSPB7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for HSPB7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in HSPB7 are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1442621431,2
    		C,--16340047(+) GGACA-/CCCCCC 1 -- int10--------
    rs601473231,2
    		C--16340049(+) CCCCCC/-GCCCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1126217761,2
    		C,--16340078(+) CTTTGC/TCTCTG 1 -- int12Minor allele frequency- T:0.04NA 122
    rs1113975341,2
    		--16340190(+) GCCCAG/CCTTTG 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs1134627951,2
    		C,--16340217(+) CTGAA-/ACAGT 
     GCTTGGC    ACAGT     		1 -- int11Minor allele frequency- ACAGTGCTTGGC:0.50CSA 2
    rs579722211,2
    		C--16340224(+) AGTGCTTGGCAC 
     AGTGC    /-    CCGCC     		1 -- int11Minor allele frequency- -:0.00NA 2
    rs1479807561,2
    		--16340264(+) GGAAAG/TAAATA 1 -- int10--------
    rs1407382331,2
    		--16340306(+) AAGGTG/TTTGCA 1 -- int10--------
    rs1501104851,2
    		--16340384(+) AGGAAC/TGCCCA 1 -- int10--------
    rs17636011,2
    		C,F,H,--16340460(-) AGAAAA/CAGACA 1 -- int130Minor allele frequency- C:0.29MN EA NA NS WA CSA 4389

    HapMap Linkage Disequilibrium report for HSPB7 (16340523 - 16346089 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HSPB7
         3 CNVs: 48155 53327 48156
    Human Gene Mutation Database (HGMD): HSPB7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB7
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPB7

    Disorders / Diseases
    for HSPB7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSPB7 for disorders           About GeneDecksing

    OMIM gene information: 610692    OMIM disorders: --

    4 diseases for HSPB7:    About MalaCards
    duchenne muscular dystrophy    muscular dystrophy    dilated cardiomyopathy    cardiomyopathy

    Human Genome Epidemiology (HuGE) Navigator: HSPB7 (6 documents)

    Export disorders for HSPB7 gene to outside databases

    Publications
    for HSPB7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPB7 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with HSPB7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin- sensitive tissues. (PubMed id 10593960)1, 2, 3 Krief S.... Bril A. (1999)
    2. HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)1, 2 Vos M.J....Kampinga H.H. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Association of plasma concentration of small heat shoc k protein B7 with acute coronary syndrome. (PubMed id 22785082)1 Chiu T.F....Yang R.B. (2012)
    7. HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GT Pase-induced remodeling in tachypaced atrial myocytes. (PubMed id 21731611)1 Ke L....Brundel B.J. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Cardiac signaling genes exhibit unexpected sequence d iversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated w ith disease. (PubMed id 20038796)1 Matkovich S.J....Dorn G.W. (2010)
    10. Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy. (PubMed id 20975947)1 Stark K....Hengstenberg C. (2010)

    External Searches for HSPB7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSPB7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27129 HGNC: 5249 AceView: HSPB7 Ensembl:ENSG00000173641 euGenes: HUgn27129
    ECgene: HSPB7 H-InvDB: HSPB7

    Other Databases showing HSPB7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSPB7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPB7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPB7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HSPB7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSPB7 gene:
    Search GeneIP for patents involving HSPB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HSPB7 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HSPB7   OriGene shRNA RFP for HSPB7  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB7   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB7  
     OriGene Protein Over-expression Lysate for HSPB7   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HSPB7   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB7  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HSPB7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPB7   OriGene Custom Protein Services for HSPB7  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPB7
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB7
     GenScript Custom Purified and Recombinant Proteins Services for HSPB7 GenScript cDNA clones with any tag delivered in your preferred vector for HSPB7
     GenScript Custom Assay Services for HSPB7 GenScript Custom Superior Antibodies Services for HSPB7
     GenScript Custom overexpressing Cell Line Services for HSPB7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSPB7 promoter
     Search Chromatin IP Primers for HSPB7
     RT2 qPCR Primer Assay in human, mouse, rat HSPB7
     GNC Network for HSPB7
     SABiosciences PCR Arrays including human, mouse, rat HSPB7
     Search Tocris compounds for HSPB7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSPB7 antibodies
     HSPB7 proteins
     HSPB7 lysates
     Antibodies for HSPB7
     See all of Abcam's Antibodies, Kits and Proteins for HSPB7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSPB7




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for HSPB7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB7
     SwitchGear 3'UTR luciferase reporter plasmids for HSPB7
     SwitchGear Promoter luciferase reporter plasmids for HSPB7
     Search ThermoFisher Antibodies for HSPB7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB7
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HSPB7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4