Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPB6 Gene

protein-coding   GIFtS: 57
GCID: GC19M036245

Heat Shock Protein, Alpha-Crystallin-Related, B6

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Protein, Alpha-Crystallin-Related, B61 2
Heat Shock 20 KDa-Like Protein P202 3
Hsp202
Heat Shock Protein Beta-62
HspB63
HSP205

External Ids:    HGNC: 265111   Entrez Gene: 1263932   Ensembl: ENSG000000047767   OMIM: 6106955   UniProtKB: O145583   

Export aliases for HSPB6 gene to outside databases

Previous GC identifers: GC19M040938 GC19M040939 GC19M032750


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPB6 Gene:
This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation.
(provided by RefSeq, Jan 2012)

GeneCards Summary for HSPB6 Gene: 
HSPB6 (heat shock protein, alpha-crystallin-related, B6) is a protein-coding gene. Diseases associated with HSPB6 include hereditary cerebral hemorrhage with amyloidosis, and cerebral hemorrhage. GO annotations related to this gene include structural constituent of eye lens and protein homodimerization activity. An important paralog of this gene is HSPB1.

Gene Wiki entry for HSPB6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPB6 gene promoter:
         GATA-3   GCNF   GATA-2   GATA-1   POU2F1   COMP1   POU2F1a   FOXO4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPB6 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPB6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

HSPB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036245:  view genomic region     (about GC identifiers)

Start:
36,245,469 bp from pter      End:
36,248,980 bp from pter
Size:
3,512 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558 (See protein sequence)
Recommended Name: Heat shock protein beta-6  
Size: 160 amino acids; 17136 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock
Secondary accessions: O14551 Q6NVI3 Q96MG9

Explore the universe of human proteins at neXtProt for HSPB6: NX_O14558

Explore proteomics data for HSPB6 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14558

  • HSPB6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPB6 Protein Expression
    REFSEQ proteins: NP_653218.1  
    ENSEMBL proteins: 
     ENSP00000468057   ENSP00000467169   ENSP00000004982  

    Human Recombinant Protein Products for HSPB6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for HSPB6
    OriGene Purified Protein for HSPB6
    OriGene Protein Over-expression Lysate for HSPB6
    OriGene MassSpec for HSPB6 
    OriGene Custom Protein Services for HSPB6
    GenScript Custom Purified and Recombinant Proteins Services for HSPB6
    Novus Biologicals HSPB6 Proteins
    Novus Biologicals HSPB6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSPB6
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19464326
    GO:0005737cytoplasm IDA19464326

    HSPB6 for ontologies           About GeneDecksing



    HSPB6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPB6
    R&D Systems Antibodies for HSPB6 (HSP20/HSPB6)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSPB6
    GenScript Custom Superior Antibodies Services for HSPB6
    Novus Biologicals HSPB6 Antibodies
    Abcam antibodies for HSPB6
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for HSPB6
    LSBio Antibodies in human, mouse, rat for HSPB6 

    Assay Products for HSPB6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSPB6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPB6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSPB: Heat shock proteins / HSPB

    4 InterPro protein domains:
     IPR002068 a-crystallin/Hsp20_dom
     IPR008978 HSP20-like_chaperone
     IPR001436 Alpha-crystallin/HSP
     IPR003090 Alpha-crystallin_N

    Graphical View of Domain Structure for InterPro Entry O14558

    ProtoNet protein and cluster: O14558

    1 Blocks protein domain: IPB002068 Heat shock protein Hsp20

    UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558
    Similarity: Belongs to the small heat shock protein (HSP20) family


    HSPB6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
    GO:0005515protein binding IPI16225851
    GO:0042803protein homodimerization activity ISS--
         
    HSPB6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPB6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPB6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPB6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPB6 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPB6:
    hsa-mir-320a (MIRT004508)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB6
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPB6:
    hsa-miR-3618 hsa-miR-25* hsa-miR-149 hsa-miR-193a-5p hsa-miR-3126-3p hsa-miR-3652 hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHSPB6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPB6
    Sirion Biotech Customized adenovirus for overexpression of HSPB6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSPB6 (see all 7)
    OriGene ORF clones in mouse, rat for HSPB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPB6 (NM_144617)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB6
    Sirion Biotech Customized lentivirus for stable overexpression of HSPB6 
                         Customized lentivirus expression plasmids for stable overexpression of HSPB6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSPB6
    Search LifeMap BioReagents cell lines for HSPB6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPB6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for HSPB6 (O145581, 2, 3 ENSP000000049824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8007683 MINT-8006832 I2D: score=2 STRING: ENSP00000306330
    HSPB8Q9UJY11, 3, ENSP000002819384EBI-739095,EBI-739074 I2D: score=2 STRING: ENSP00000281938
    CRYABP025113I2D: score=1 
    HSPB1P047923I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006937regulation of muscle contraction IEA--
    GO:0006950response to stress IEA--

    HSPB6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPB6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPB6

    5 Novoseek inferred chemical compound relationships for HSPB6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 33.1 7 9408240 (2), 10037721 (2), 17993590 (1), 18755793 (1)
    oxygen 0 1 10484413 (1)
    nitric oxide 0 1 15832944 (1)
    calcium 0 1 10658928 (1)
    serine 0 3 15218470 (1), 15598710 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPB6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPB6 gene: 
    NM_144617.2  

    Unigene Clusters for HSPB6:

    Heat shock protein, alpha-crystallin-related, B6
    Hs.534538  [show with all ESTs], Hs.744178  [show with all ESTs]
    Unigene Representative Sequences: NM_144617, AK026458
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592984 ENST00000587965 ENST00000004982(uc002obn.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB6
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPB6:
    hsa-miR-3618 hsa-miR-25* hsa-miR-149 hsa-miR-193a-5p hsa-miR-3126-3p hsa-miR-3652 hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHSPB6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB6
    Clone
    Products:
         
    OriGene clones in human, mouse for HSPB6 (see all 7)
    OriGene ORF clones in mouse, rat for HSPB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPB6 (NM_144617)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB6
    Sirion Biotech Customized lentivirus for stable overexpression of HSPB6 
                         Customized lentivirus expression plasmids for stable overexpression of HSPB6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPB6
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPB6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB6

    Additional mRNA sequence: AK026458.1 

    11 DOTS entries:

    DT.100788513  DT.99980087  DT.216531  DT.100788516  DT.121488831  DT.121488806  DT.121488848  DT.87046426 
    DT.100788515  DT.121488786  DT.97844490 

    24/207 AceView cDNA sequences (see all 207):

    F30902 AI933014 BF837737 R79117 F31452 BF837688 AI692843 AI583430 
    AJ712017 CN481632 BM021353 BM726227 CN482710 BM694413 NM_144617 AW966769 
    AI720539 BI837440 F31966 BM055214 BQ022051 AK056951 F30774 CR618274 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPB6 expression in normal human tissues (normalized intensities)      HSPB6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSPB6 Expression
    About this image


    HSPB6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Fibroblast
             Detroit 551
             skin ; fibroblasts   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             smooth muscle ; smooth muscle cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             Brain Pericytes   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; cells in endometrial stroma   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             urinary bladder ; urothelial cells   

    See HSPB6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPB6

    SOURCE GeneReport for Unigene clusters: Hs.534538 Hs.744178
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB6: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPB6
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPB6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HSPB6 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspb61 , 5 heat shock protein, alpha-crystallin-related, B61, 5 82.92(n)1
    89.37(a)1
      7 (18.56 cM)5
    2439121  NM_001012401.21  NP_001012401.11 
     305521785 
    lizard
    (Anolis carolinensis)
    Reptilia HSPB66
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343276.1(1462581-1471512)
    zebrafish
    (Danio rerio)
    Actinopterygii cryaba6
    hspb66
    heat shock protein, alpha-crystallin-related, b6
    36(a)
    32(a)
    possible ortholog
    1 ↔ 1
    15(17063601-17068283)
    15(36257981-36260439)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp67Ba6
    Hsp236
    (see all 8)
    Heat shock protein 23
    (see all 8)
    8(a)
    27(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    3L(9370902-9372634)
    3L(9374982-9375865)
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-436
    hsp-16.416
    (see all 13)
    Heat shock protein Hsp-16.41
    (see all 13)
    8(a)
    26(a)
    (see all 13)
    many ↔ many
    many ↔ many
    (see all 13)
    X(6233149-6235541)
    V(1805233-1805875)


    ENSEMBL Gene Tree for HSPB6 (if available)
    TreeFam Gene Tree for HSPB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPB6 gene
    HSPB12  CRYAA2  CRYAB2  HSPB22  HSPB82  HSPB2-C11orf522  HSPB32  
    5 SIMAP similar genes for HSPB6 using alignment to 2 protein entries:     HSPB6_HUMAN (see all proteins):
    CRYAA    CRYAB    HSPB2    HSPB8    HSPB3

    HSPB6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/19 SNPs in HSPB6 are shown (see all 19)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379409991,2
    --36404715(+) GAGGGC/TTGTCT 1 -- ut310--------
    rs1901352781,2
    --36404885(+) GTGCTA/GGTAGG 1 -- ut310--------
    rs1490529271,2
    --36404945(+) TGTGAC/GAGCGA 1 -- ut310--------
    rs1430629371,2
    --36405078(+) GATCGG/TCTTTA 1 -- ut310--------
    rs115490301,2
    C,F--36405131(-) GGAGGG/CGGCTG 1 -- ut31 ese35Minor allele frequency- C:0.12NA WA EA 362
    rs2003587541,2
    --36405267(+) ACGGTA/GGAACT 2 H Y mis10--------
    rs762284061,2
    C--36405403(-) ACGCGC/GGCCAC 2 R G mis10--------
    rs1403616601,2
    C,F--36405427(+) TTCGCC/TCACCA 2 S G mis11Minor allele frequency- T:0.00NA 2952
    rs1503611271,2
    C,F--36405432(+) CCACCA/GCCTTG 2 A V mis11Minor allele frequency- G:0.00NA 3008
    rs1482236291,2
    C--36405695(+) CCTCCC/TCCTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSPB6 (36245469 - 36248980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HSPB6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3853n71CNV Loss21882294
    dgv3852n71CNV Loss21882294
    nsv911636CNV Loss21882294
    nsv819381CNV Gain19587683


    Human Gene Mutation Database (HGMD): HSPB6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPB6
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPB6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610695    OMIM disorders: --

    17 diseases for HSPB6:    About MalaCards
    hereditary cerebral hemorrhage with amyloidosis    cerebral hemorrhage    cerebral amyloid angiopathy    brain disease
    endocarditis    amyloidosis    keloids    cerebritis
    thrombosis    alzheimer's disease    ischemia    myopathy
    hypoxia    rheumatoid arthritis    arthritis    hepatocellular carcinoma
    melanoma


    HSPB6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for HSPB6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 76 48 14717697 (3), 16038604 (3), 19100870 (3), 17109079 (2) (see all 26)
    cerebral amyloid angiopathy 73.9 1 16635482 (1)
    vasospasm 52.3 3 15349104 (2), 15829720 (1)
    senile plaques 43.4 1 16635482 (1)
    brain diseases 38.9 1 16635482 (1)
    alzheimers disease 30.7 1 16635482 (1)
    thrombosis 4.75 1 15349104 (1)
    ischemia 0 6 19850943 (6), 16099377 (1)

    Genetic Association Database (GAD): HSPB6
    Human Genome Epidemiology (HuGE) Navigator: HSPB6 (1 document)

    Export disorders for HSPB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPB6 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with HSPB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Some properties of human small heat shock protein Hsp20 (HspB6). (PubMed id 14717697)1, 3, 9 Bukach O.V....Gusev N.B. (2004)
    2. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. (PubMed id 18790732)1, 4, 9 Nicolaou P....Kranias E.G. (2008)
    3. HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)1, 2 Vos M.J....Kampinga H.H. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PubMed id 12820654)1, 3 KappAc G....de Jong W.W. (2003)
    8. Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. (PubMed id 8195168)1, 2 Kato K.... Asano T. (1994)
    9. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. (PubMed id 19850943)1, 9 Qian J....Kranias E.G. (2009)
    10. Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. (PubMed id 17109079)1, 9 Chernik I.S....Gusev N.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126393 HGNC: 26511 AceView: HSPB6 Ensembl:ENSG00000004776 euGenes: HUgn126393
    ECgene: HSPB6 H-InvDB: HSPB6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPB6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPB6 gene:
    Search GeneIP for patents involving HSPB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPB6
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HSPB6 (HSP20/HSPB6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HSPB6  
     OriGene qPCR primer pairs and template standards for HSPB6   OriGene Protein Over-expression Lysate for HSPB6  
     OriGene MassSpec something-or-other for HSPB6   OriGene clones in human, mouse for HSPB6  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSPB6   OriGene Purified Protein for HSPB6  
     OriGene ORF clones in mouse, rat for HSPB6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPB6   OriGene Custom Protein Services for HSPB6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPB6
     QIAGEN SeqTarget long-range PCR primers for resequencing HSPB6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB6
     GenScript Custom Purified and Recombinant Proteins Services for HSPB6 GenScript cDNA clones with any tag delivered in your preferred vector for HSPB6
     GenScript Custom Assay Services for HSPB6 GenScript Custom Superior Antibodies Services for HSPB6
     GenScript Custom overexpressing Cell Line Services for HSPB6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSPB6 promoter
     Search Chromatin IP Primers for HSPB6
     RT2 qPCR Primer Assay in human, mouse, rat HSPB6
     GNC Network for HSPB6
     SABiosciences PCR Arrays including human, mouse, rat HSPB6
     Search Tocris compounds for HSPB6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for HSPB6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSPB6 antibodies
     HSPB6 proteins
     HSPB6 lysates
     Antibodies for HSPB6
     See all of Abcam's Antibodies, Kits and Proteins for HSPB6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSPB6




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HSPB6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6
     SwitchGear 3'UTR luciferase reporter plasmids for HSPB6
     SwitchGear Promoter luciferase reporter plasmids for HSPB6
     ThermoFisher Antibodies for HSPB6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPB6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPB6
    Customized:
     lentivirus for stable overexpression of HSPB6
     lentivirus expression plasmids for stable overexpression of HSPB6
     adenovirus for overexpression of HSPB6
     LSBio Antibodies in human, mouse, rat for HSPB6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSPB6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4