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Aliases for HSPB6 Gene

Aliases for HSPB6 Gene

  • Heat Shock Protein Family B (Small) Member 6 2 3 5
  • Heat Shock Protein, Alpha-Crystallin-Related, B6 2 3
  • Protein Phosphatase 1, Regulatory Subunit 91 2 3
  • Heat Shock 20 KDa-Like Protein P20 3 4
  • Heat Shock Protein Family B (Small) Member B6 3
  • Epididymis Luminal Protein 55 3
  • Heat Shock Protein Beta-6 3
  • PPP1R91 3
  • HEL55 3
  • Hsp20 3
  • HspB6 4

External Ids for HSPB6 Gene

Previous GeneCards Identifiers for HSPB6 Gene

  • GC19M040938
  • GC19M040939
  • GC19M036245
  • GC19M032750
  • GC19M035774
  • GC19M035913
  • GC19M035938
  • GC19M036806

Summaries for HSPB6 Gene

Entrez Gene Summary for HSPB6 Gene

  • This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSPB6 Gene

HSPB6 (Heat Shock Protein Family B (Small) Member 6) is a Protein Coding gene. Diseases associated with HSPB6 include Cerebral Amyloid Angiopathy. GO annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is CRYAB.

Gene Wiki entry for HSPB6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB6 Gene

Genomics for HSPB6 Gene

Regulatory Elements for HSPB6 Gene

Enhancers for HSPB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035753 0.6 ENCODE 0.8 +1.8 1822 6.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 U2AF1L4 COX6B1 ZNF146 LINC01766 ENSG00000267626 ENSG00000270544 ENSG00000271171 LINC00904 LOC100419842 ZNF260
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSPB6 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000345966 -21 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207
ENSR00001817280 1879 1601 ZNF263 KLF1 ZNF792 MNT ZBTB7A ZIC2 NR2F2 HIC1 POLR2A GLIS1

Genomic Location for HSPB6 Gene

Chromosome:
19
Start:
35,754,566 bp from pter
End:
35,758,079 bp from pter
Size:
3,514 bases
Orientation:
Minus strand

Genomic View for HSPB6 Gene

Genes around HSPB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB6 Gene

Proteins for HSPB6 Gene

  • Protein details for HSPB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14558-HSPB6_HUMAN
    Recommended name:
    Heat shock protein beta-6
    Protein Accession:
    O14558
    Secondary Accessions:
    • O14551
    • Q6NVI3
    • Q96MG9

    Protein attributes for HSPB6 Gene

    Size:
    160 amino acids
    Molecular mass:
    17136 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HSPB6 Gene

neXtProt entry for HSPB6 Gene

Post-translational modifications for HSPB6 Gene

Other Protein References for HSPB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HSPB6

No data available for DME Specific Peptides for HSPB6 Gene

Domains & Families for HSPB6 Gene

Suggested Antigen Peptide Sequences for HSPB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14558

UniProtKB/Swiss-Prot:

HSPB6_HUMAN :
  • Belongs to the small heat shock protein (HSP20) family.
Family:
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB6: view

Function for HSPB6 Gene

Gene Ontology (GO) - Molecular Function for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
GO:0005515 protein binding IPI 16225851
GO:0042803 protein homodimerization activity ISS --
GO:0051087 chaperone binding IPI 23948568
genes like me logo Genes that share ontologies with HSPB6: view

Phenotypes for HSPB6 Gene

genes like me logo Genes that share phenotypes with HSPB6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPB6 Gene

Localization for HSPB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB6 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPB6 Gene COMPARTMENTS Subcellular localization image for HSPB6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19464326
GO:0005737 cytoplasm IEA,IDA 19464326
genes like me logo Genes that share ontologies with HSPB6: view

Pathways & Interactions for HSPB6 Gene

SuperPathways for HSPB6 Gene

No Data Available

SIGNOR curated interactions for HSPB6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006937 regulation of muscle contraction IEA --
genes like me logo Genes that share ontologies with HSPB6: view

No data available for Pathways by source for HSPB6 Gene

Drugs & Compounds for HSPB6 Gene

(5) Drugs for HSPB6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HSPB6: view

Transcripts for HSPB6 Gene

mRNA/cDNA for HSPB6 Gene

Unigene Clusters for HSPB6 Gene

Heat shock protein, alpha-crystallin-related, B6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB6 Gene

No ASD Table

Relevant External Links for HSPB6 Gene

GeneLoc Exon Structure for
HSPB6
ECgene alternative splicing isoforms for
HSPB6

Expression for HSPB6 Gene

mRNA expression in normal human tissues for HSPB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPB6 Gene

This gene is overexpressed in Muscle - Skeletal (x8.4) and Heart - Left Ventricle (x5.8).

Protein differential expression in normal tissues from HIPED for HSPB6 Gene

This gene is overexpressed in Cardia (14.2), Tonsil (7.4), and Rectum (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPB6 Gene



Protein tissue co-expression partners for HSPB6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPB6 Gene:

HSPB6

SOURCE GeneReport for Unigene cluster for HSPB6 Gene:

Hs.534538
genes like me logo Genes that share expression patterns with HSPB6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HSPB6 Gene

Orthologs for HSPB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPB6 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia HSPB6 34 35
  • 90.28 (n)
cow
(Bos Taurus)
Mammalia HSPB6 34 35
  • 85.83 (n)
mouse
(Mus musculus)
Mammalia Hspb6 34 16 35
  • 82.64 (n)
rat
(Rattus norvegicus)
Mammalia Hspb6 34
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPB6 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPB6 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hspb6 35
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 35
  • 32 (a)
OneToMany
Species where no ortholog for HSPB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB6 Gene

ENSEMBL:
Gene Tree for HSPB6 (if available)
TreeFam:
Gene Tree for HSPB6 (if available)

Paralogs for HSPB6 Gene

(5) SIMAP similar genes for HSPB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB6: view

Variants for HSPB6 Gene

Sequence variations from dbSNP and Humsavar for HSPB6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111468214 -- 35,754,567(+) GCAGT(A/C/T)GGCAG intron-variant, utr-variant-3-prime
rs113189543 -- 35,754,348(+) CCCCT(A/C)GTAGG intron-variant
rs11332397 -- 35,757,787(+) GCGCG(-/C)CCCCC upstream-variant-2KB
rs113370944 -- 35,757,951(+) GTGCA(A/C)GGTCT upstream-variant-2KB
rs11549029 -- 35,756,950(-) GTTGC(C/T)CGGAC upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HSPB6 Gene

Variant ID Type Subtype PubMed ID
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781
nsv819381 CNV gain 19587683
nsv953286 CNV deletion 24416366

Variation tolerance for HSPB6 Gene

Gene Damage Index Score: 1.36; 26.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB6 Gene

Human Gene Mutation Database (HGMD)
HSPB6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB6 Gene

Disorders for HSPB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPB6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral amyloid angiopathy
  • cerebral amyloid angiopathy, cst3-related
- elite association - COSMIC cancer census association via MalaCards
Search HSPB6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPB6

Genetic Association Database (GAD)
HSPB6
Human Genome Epidemiology (HuGE) Navigator
HSPB6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPB6
genes like me logo Genes that share disorders with HSPB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB6 Gene

Publications for HSPB6 Gene

  1. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. (PMID: 18790732) Nicolaou P. … Kranias E.G. (J. Biol. Chem. 2008) 3 22 46 64
  2. Some properties of human small heat shock protein Hsp20 (HspB6). (PMID: 14717697) Bukach O.V. … Gusev N.B. (Eur. J. Biochem. 2004) 2 3 22 64
  3. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. (PMID: 19845507) Fuchs M. … Landry J. (Biochem. J. 2010) 3 22 64
  4. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. (PMID: 18787533) Lopes L.B. … Brophy C.M. (J. Invest. Dermatol. 2009) 3 22 64
  5. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos M.J. … Kampinga H.H. (Biochim. Biophys. Acta 2009) 3 4 64

Products for HSPB6 Gene

Sources for HSPB6 Gene

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