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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPB6 Gene

protein-coding GIFtS: 56
GCID: GC19M036245

heat shock protein, alpha-crystallin-related, B6

Explore 19 diseases affiliated with
HSPB6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock Protein, Alpha-Crystallin-Related, B6¹ ²		Heat Shock Protein Beta-6²
Hsp20¹ ²		HspB6³
Heat Shock 20 KDa-Like Protein P20² ³		HSP20⁵
FLJ32389¹

External Ids:	HGNC: 26511¹	Entrez Gene: 126393²	Ensembl: ENSG00000004776⁷	OMIM: 610695⁵	UniProtKB: O14558³

Export aliases for HSPB6 gene to outside databases

Previous GC identifers: GC19M040938 GC19M040939 GC19M032750

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPB6:

This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. (provided

by RefSeq, Jan 2012)

Gene Wiki entry for HSPB6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPB6 gene promoter:
GATA-3 GCNF GATA-2 GATA-1 POU2F1 COMP1 POU2F1a FOXO4 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPB6 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPB6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.13

HSPB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB6 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M036245: view genomic region (about GC identifiers)

Start:	36,245,469 bp from pter	End:	36,248,980 bp from pter
Size:	3,512 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558 (See protein sequence)

Recommended Name: Heat shock protein beta-6

Size: 160 amino acids; 17136 Da

Subunit: Homodimer (By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock

Secondary accessions: O14551 Q6NVI3 Q96MG9

Explore the universe of human proteins at neXtProt for HSPB6: NX_O14558

Post-translational modifications:

The N-terminus is blocked¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14558

HSPB6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653218.1

ENSEMBL proteins:

ENSP00000468057 ENSP00000467169 ENSP00000004982

Human Recombinant Protein Products for HSPB6:

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	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	19464326
GO:0005737	cytoplasm	IDA	19464326

HSPB6 for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPB6 for domains About GeneDecksing

4 InterPro domains/families:

IPR002068 a-crystallin/Hsp20_dom

IPR008978 HSP20-like_chaperone

IPR001436 Alpha-crystallin/HSP

IPR003090 Alpha-crystallin_N

Graphical View of Domain Structure for InterPro Entry O14558

ProtoNet protein and cluster: O14558

1 Blocks protein family: IPB002068 Heat shock protein Hsp20

UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558

Similarity: Belongs to the small heat shock protein (HSP20) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005212	structural constituent of eye lens	IEA	--
GO:0005515	protein binding	IPI	16225851
GO:0042803	protein homodimerization activity	ISS	--

HSPB6 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPB6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for HSPB6 (O14558^{1, 2, 3} ENSP00000004982⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-8007683 MINT-8006832 I2D: score=2 STRING: ENSP00000306330
HSPB8	Q9UJY1¹^,³, ENSP00000281938⁴	EBI-739095,EBI-739074 I2D: score=2 STRING: ENSP00000281938
CRYAB	P02511³	I2D: score=1
HSPB1	P04792³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006937	regulation of muscle contraction	--	--
GO:0006950	response to stress	IEA	--

HSPB6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPB6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPB6
5 Novoseek chemical compound relationships for HSPB6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
forskolin	33.1	7	9408240 (2), 10037721 (2), 17993590 (1), 18755793 (1)
oxygen	0	1	10484413 (1)
nitric oxide	0	1	15832944 (1)
calcium	0	1	10658928 (1)
serine	0	3	15218470 (1), 15598710 (1)

Search CenterWatch for drugs/clinical trials and news about HSPB6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPB6 gene:

NM_144617.2

Unigene Clusters for HSPB6:

Heat shock protein, alpha-crystallin-related, B6

Hs.534538 [show with all ESTs], Hs.744178 [show with all ESTs]

Unigene Representative Sequences: NM_144617, AK026458

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000592984 ENST00000587965 ENST00000004982(uc002obn.1)

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Additional cDNA sequence: AK026458.1

11 DOTS entries:

DT.100788513 DT.99980087 DT.216531 DT.100788516 DT.121488831 DT.121488806 DT.121488848 DT.87046426

DT.100788515 DT.121488786 DT.97844490

24/207 AceView cDNA sequences (see all 207):

AW966769 CR603021 BF837737 BC068046 AI042145 BM055214 F31797 R79117

F31127 CR618274 AI692843 AJ712017 CA393792 NM_144617 AK056951 AI093511

BM694413 AI720539 R75610 F30774 F30902 CN482710 BM726227 H28557

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HSPB6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPB6

SOURCE GeneReport for Unigene clusters: Hs.534538 Hs.744178

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB6:

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HSPB6 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	HSPB6⁶	--	54(a)	1 ↔ 1	GL343276.1(1464083-1471512)
zebrafish (Danio rerio)	Actinopterygii	hspb6⁶	heat shock protein, alpha-crystallin-related, b6	35(a)	1 ↔ 1	15(36257981-36260439)
fruit fly (Drosophila melanogaster)	Insecta	l(2)efl⁶ CG7409⁶ (see all 9)	--	30(a) 27(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2R(19572174-19573063) 3L(7747509-7748268)

ENSEMBL Gene Tree for HSPB6 (if available)
TreeFam Gene Tree for HSPB6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPB6 gene

CRYAA² HSPB1² CRYAB² HSPB2-C11orf52² HSPB8² HSPB2² HSPB3²

5 SIMAP similar genes for HSPB6 using alignment to 2 protein entries: HSPB6_HUMAN (see all proteins):

CRYAA CRYAB HSPB2 HSPB8 HSPB3

HSPB6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75341119^1,2		--	32752202(+)	`AGATAT/GCGGGC`	1	--	us2k¹		2		CSA NA	121
rs61497420^1,2	C	--	32752303(+)	`CGGATC/AACCAG`	1	--	us2k¹		2		WA	120
rs8107521^1,2	C	--	32752472(+)	`TTCGGT/AGCTGC`	1	--	us2k¹		2		CSA	3
rs231240^1,2	C,F,H	--	32753072(+)	`CACAGC/TGTGGT`	1	--	us2k¹		7		EA NA MN NS WA	480
rs231239^1,2	C,F	--	32753143(+)	`CTCCCC/TCCTGG`	1	--	us2k¹ trp³		6		EA NA MN WA	358
rs77218797^1,2	F	--	32753331(+)	`TGGTGC/AGCAGA`	1	--	us2k¹		1		NA	120
rs113370944^1,2		--	32753732(+)	`GTGCAC/AGGTCT`	1	--	us2k¹		2		CSA WA	120
rs58561864^1,2	C	--	32753855(+)	`TTTCAT/CTNNNN`	1	--	us2k¹		4		WA NA EA	360
rs137940999^1,2		--	36246002(+)	`GAGGGC/TTGTCT`	1	--	ut3¹		0	--	--	--	--
rs190135278^1,2		--	36246172(+)	`GTGCTA/GGTAGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HSPB6 (36245469 - 36248980 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSPB6
1 Indel: 58873
Human Gene Mutation Database (HGMD): HSPB6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPB6 for disorders           About GeneDecksing

OMIM gene information: 610695    OMIM disorders: --

19 diseases for HSPB6:    About MalaCards

cerebral amyloid angiopathy hereditary cerebral hemorrhage with amyloidosis cerebral hemorrhage amyloidosis

brain disease cerebritis thrombosis alzheimer's disease

rheumatoid arthritis keloids endocarditis hermaphroditism

ischemia hepatocellular carcinoma arthritis myopathy

hypoxia melanoma carcinoma

8 Novoseek disease relationships for HSPB6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	76	48	14717697 (3), 16038604 (3), 19100870 (3), 17109079 (2) (see all 26)
cerebral amyloid angiopathy	73.9	1	16635482 (1)
vasospasm	52.3	3	15349104 (2), 15829720 (1)
senile plaques	43.4	1	16635482 (1)
brain diseases	38.9	1	16635482 (1)
alzheimers disease	30.7	1	16635482 (1)
thrombosis	4.75	1	15349104 (1)
ischemia	0	6	19850943 (6), 16099377 (1)

Human Genome Epidemiology (HuGE) Navigator: HSPB6 (1 document)

Export disorders for HSPB6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSPB6 gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with HSPB6)

Utopia: connect your pdf to the dynamic
world of online information

Some properties of human small heat shock protein Hsp20 (HspB6). (PubMed id 14717697)^{1, 3, 9} Bukach O.V....Gusev N.B. (2004)
HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)^{1, 2} Vos M.J....Kampinga H.H. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PubMed id 12820654)^{1, 3} KappAc G....de Jong W.W. (2003)
Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. (PubMed id 8195168)^{1, 2} Kato K.... Asano T. (1994)
Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. (PubMed id 19850943)^{1, 9} Qian J....Kranias E.G. (2009)
Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. (PubMed id 17109079)^{1, 9} Chernik I.S....Gusev N.B. (2007)
Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. (PubMed id 18790732)^{1, 9} Nicolaou P....Kranias E.G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 126393	HGNC: 26511	AceView: HSPB6	Ensembl:ENSG00000004776	euGenes: HUgn126393
ECgene: HSPB6	H-InvDB: HSPB6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HSPB6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HSPB6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HSPB6 gene:
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HSPB6 Gene

heat shock protein, alpha-crystallin-related, B6

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HSPB6 Gene

heat shock protein, alpha-crystallin-related, B6

Aliasesfor HSPB6 gene

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Protein Domains /Familiesfor HSPB6 gene

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