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Aliases for HSPB6 Gene

Aliases for HSPB6 Gene

  • Heat Shock Protein Family B (Small) Member 6 2 3 5
  • Heat Shock Protein, Alpha-Crystallin-Related, B6 2 3
  • Heat Shock 20 KDa-Like Protein P20 3 4
  • Heat Shock Protein Family B (Small) Member B6 3
  • Protein Phosphatase 1, Regulatory Subunit 91 3
  • Epididymis Luminal Protein 55 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 91 2
  • PPP1R91 3
  • HEL55 3
  • Hsp20 3
  • HspB6 4

External Ids for HSPB6 Gene

Previous GeneCards Identifiers for HSPB6 Gene

  • GC19M040938
  • GC19M040939
  • GC19M036245
  • GC19M032750
  • GC19M035774
  • GC19M035913

Summaries for HSPB6 Gene

Entrez Gene Summary for HSPB6 Gene

  • This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSPB6 Gene

HSPB6 (Heat Shock Protein Family B (Small) Member 6) is a Protein Coding gene. Diseases associated with HSPB6 include Cerebral Amyloid Angiopathy. GO annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is HSPB2-C11orf52.

Gene Wiki entry for HSPB6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB6 Gene

Genomics for HSPB6 Gene

Regulatory Elements for HSPB6 Gene

Enhancers for HSPB6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPB6 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPB6 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPB6 Gene

35,754,566 bp from pter
35,758,079 bp from pter
3,514 bases
Minus strand

Genomic View for HSPB6 Gene

Genes around HSPB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB6 Gene

Proteins for HSPB6 Gene

  • Protein details for HSPB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-6
    Protein Accession:
    Secondary Accessions:
    • O14551
    • Q6NVI3
    • Q96MG9

    Protein attributes for HSPB6 Gene

    160 amino acids
    Molecular mass:
    17136 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HSPB6 Gene

neXtProt entry for HSPB6 Gene

Proteomics data for HSPB6 Gene at MOPED

Post-translational modifications for HSPB6 Gene

Other Protein References for HSPB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for Hsp20

No data available for DME Specific Peptides for HSPB6 Gene

Domains & Families for HSPB6 Gene

Suggested Antigen Peptide Sequences for HSPB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB6: view

Function for HSPB6 Gene

Gene Ontology (GO) - Molecular Function for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with HSPB6: view

Phenotypes for HSPB6 Gene

GenomeRNAi human phenotypes for HSPB6:
genes like me logo Genes that share phenotypes with HSPB6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPB6 Gene

Localization for HSPB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB6 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB6 Gene COMPARTMENTS Subcellular localization image for HSPB6 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
extracellular 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for HSPB6 Gene

Pathways & Interactions for HSPB6 Gene

SuperPathways for HSPB6 Gene

No Data Available

SIGNOR curated interactions for HSPB6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HSPB6 Gene


No data available for Pathways by source for HSPB6 Gene

Drugs & Compounds for HSPB6 Gene

(4) Drugs for HSPB6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HSPB6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPB6: view

Transcripts for HSPB6 Gene

mRNA/cDNA for HSPB6 Gene

Unigene Clusters for HSPB6 Gene

Heat shock protein, alpha-crystallin-related, B6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB6 Gene

No ASD Table

Relevant External Links for HSPB6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB6 Gene

mRNA expression in normal human tissues for HSPB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPB6 Gene

This gene is overexpressed in Muscle - Skeletal (x8.4) and Heart - Left Ventricle (x5.8).

Protein differential expression in normal tissues from HIPED for HSPB6 Gene

This gene is overexpressed in Cardia (14.2), Tonsil (7.4), and Rectum (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPB6 Gene

SOURCE GeneReport for Unigene cluster for HSPB6 Gene Hs.534538

genes like me logo Genes that share expression patterns with HSPB6: view

Protein tissue co-expression partners for HSPB6 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HSPB6 Gene

Orthologs for HSPB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB6 35
  • 85.83 (n)
  • 90.62 (a)
HSPB6 36
  • 90 (a)
(Canis familiaris)
Mammalia HSPB6 35
  • 90.28 (n)
  • 93.75 (a)
HSPB6 36
  • 91 (a)
(Mus musculus)
Mammalia Hspb6 35
  • 82.64 (n)
  • 90.28 (a)
Hspb6 16
Hspb6 36
  • 88 (a)
(Pan troglodytes)
Mammalia HSPB6 35
  • 99.58 (n)
  • 100 (a)
HSPB6 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Hspb6 35
  • 81.94 (n)
  • 91.67 (a)
(Monodelphis domestica)
Mammalia HSPB6 36
  • 76 (a)
(Anolis carolinensis)
Reptilia HSPB6 36
  • 57 (a)
(Danio rerio)
Actinopterygii hspb6 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 36
  • 32 (a)
Species with no ortholog for HSPB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB6 Gene

Gene Tree for HSPB6 (if available)
Gene Tree for HSPB6 (if available)

Paralogs for HSPB6 Gene

(5) SIMAP similar genes for HSPB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB6: view

Variants for HSPB6 Gene

Sequence variations from dbSNP and Humsavar for HSPB6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs140361660 -- 35,755,813(+) TTCGC(C/T)CACCA reference, missense
rs141923354 -- 35,756,107(+) CCTCT(C/T)CCCCG intron-variant
rs76228406 -- 35,755,789(+) ACGCG(C/G/T)GCCAC reference, missense
rs143062937 -- 35,755,464(+) GATCG(G/T)CTTTA utr-variant-3-prime
rs190135278 -- 35,755,271(+) GTGCT(A/G)GTAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPB6 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv911636 CNV Loss 21882294
nsv819381 CNV Gain 19587683

Variation tolerance for HSPB6 Gene

Gene Damage Index Score: 1.36; 26.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB6 Gene

Disorders for HSPB6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPB6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebral amyloid angiopathy
  • dutch hereditary cerebral amyloid angiopathy
- elite association - COSMIC cancer census association via MalaCards
Search HSPB6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPB6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB6 Gene

Publications for HSPB6 Gene

  1. Some properties of human small heat shock protein Hsp20 (HspB6). (PMID: 14717697) Bukach O.V. … Gusev N.B. (Eur. J. Biochem. 2004) 2 3 23 67
  2. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. (PMID: 19845507) Fuchs M. … Landry J. (Biochem. J. 2010) 3 23
  3. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. (PMID: 18787533) Lopes L.B. … Brophy C.M. (J. Invest. Dermatol. 2009) 3 23
  4. Crystal structures of alpha-crystallin domain dimers of alphaB- crystallin and Hsp20. (PMID: 19646995) Bagneris C. … Slingsby C. (J. Mol. Biol. 2009) 3 23
  5. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. (PMID: 19850943) Qian J. … Kranias E.G. (Circ. Res. 2009) 3 23

Products for HSPB6 Gene

Sources for HSPB6 Gene