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Aliases for HSPB6 Gene

Aliases for HSPB6 Gene

  • Heat Shock Protein, Alpha-Crystallin-Related, B6 2 3
  • Heat Shock 20 KDa-Like Protein P20 3 4
  • Hsp20 3 6
  • Protein Phosphatase 1, Regulatory Subunit 91 3
  • Epididymis Luminal Protein 55 3
  • Heat Shock Protein Beta-6 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 91 2
  • PPP1R91 3
  • HEL55 3
  • HspB6 4

External Ids for HSPB6 Gene

Previous GeneCards Identifiers for HSPB6 Gene

  • GC19M040938
  • GC19M040939
  • GC19M036245
  • GC19M032750

Summaries for HSPB6 Gene

Entrez Gene Summary for HSPB6 Gene

  • This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSPB6 Gene

HSPB6 (Heat Shock Protein, Alpha-Crystallin-Related, B6) is a Protein Coding gene. Diseases associated with HSPB6 include cerebral hemorrhage and cerebral amyloid angiopathy. GO annotations related to this gene include protein homodimerization activity and structural constituent of eye lens. An important paralog of this gene is CRYAA.

Gene Wiki entry for HSPB6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB6 Gene

Genomics for HSPB6 Gene

Regulatory Elements for HSPB6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPB6 Gene

35,754,566 bp from pter
35,758,079 bp from pter
3,514 bases
Minus strand

Genomic View for HSPB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB6 Gene

Proteins for HSPB6 Gene

  • Protein details for HSPB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-6
    Protein Accession:
    Secondary Accessions:
    • O14551
    • Q6NVI3
    • Q96MG9

    Protein attributes for HSPB6 Gene

    160 amino acids
    Molecular mass:
    17136 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HSPB6 Gene

neXtProt entry for HSPB6 Gene

Proteomics data for HSPB6 Gene at MOPED

Post-translational modifications for HSPB6 Gene

Other Protein References for HSPB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPB6 Gene

Domains for HSPB6 Gene

Suggested Antigen Peptide Sequences for HSPB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB6: view

Function for HSPB6 Gene

Gene Ontology (GO) - Molecular Function for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005212 structural constituent of eye lens IEA --
GO:0005515 protein binding IPI 16225851
GO:0042803 protein homodimerization activity ISS --
genes like me logo Genes that share ontologies with HSPB6: view

Animal Model Products

miRNA for HSPB6 Gene

miRTarBase miRNAs that target HSPB6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPB6 Gene

Localization for HSPB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB6 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB6 Gene COMPARTMENTS Subcellular localization image for HSPB6 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
genes like me logo Genes that share ontologies with HSPB6: view

Pathways for HSPB6 Gene

SuperPathways for HSPB6 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSPB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006937 regulation of muscle contraction IEA --
GO:0006950 response to stress --
genes like me logo Genes that share ontologies with HSPB6: view

No data available for Pathways by source for HSPB6 Gene

Drugs for HSPB6 Gene

(5) Novoseek inferred chemical compound relationships for HSPB6 Gene

Compound -log(P) Hits PubMed IDs
forskolin 33.1 6
calcium 0 1
serine 0 2
oxygen 0 1
nitric oxide 0 1
genes like me logo Genes that share compounds with HSPB6: view

Transcripts for HSPB6 Gene

mRNA/cDNA for HSPB6 Gene

Unigene Clusters for HSPB6 Gene

Heat shock protein, alpha-crystallin-related, B6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB6 Gene

No ASD Table

Relevant External Links for HSPB6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB6 Gene

mRNA expression in normal human tissues for HSPB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPB6 Gene

This gene is overexpressed in Muscle - Skeletal (8.4) and Heart - Left Ventricle (5.8).

Protein differential expression in normal tissues for HSPB6 Gene

This gene is overexpressed in Cardia (14.2), Tonsil (7.4), and Rectum (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSPB6 Gene

SOURCE GeneReport for Unigene cluster for HSPB6 Gene Hs.534538

genes like me logo Genes that share expressions with HSPB6: view

Expression partners for HSPB6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HSPB6 Gene

Orthologs for HSPB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB6 35
  • 85.83 (n)
  • 90.62 (a)
HSPB6 36
  • 90 (a)
(Canis familiaris)
Mammalia HSPB6 35
  • 90.28 (n)
  • 93.75 (a)
HSPB6 36
  • 91 (a)
(Mus musculus)
Mammalia Hspb6 35
  • 82.64 (n)
  • 90.28 (a)
Hspb6 16
Hspb6 36
  • 88 (a)
(Pan troglodytes)
Mammalia HSPB6 35
  • 99.58 (n)
  • 100 (a)
HSPB6 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Hspb6 35
  • 81.94 (n)
  • 91.67 (a)
(Monodelphis domestica)
Mammalia HSPB6 36
  • 76 (a)
(Anolis carolinensis)
Reptilia HSPB6 36
  • 57 (a)
(Danio rerio)
Actinopterygii hspb6 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.195 36
  • 32 (a)
Species with no ortholog for HSPB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB6 Gene

Gene Tree for HSPB6 (if available)
Gene Tree for HSPB6 (if available)

Paralogs for HSPB6 Gene

Paralogs for HSPB6 Gene

(5) SIMAP similar genes for HSPB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB6: view

Variants for HSPB6 Gene

Sequence variations from dbSNP and Humsavar for HSPB6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11549030 -- 35,755,517(-) GGAGG(C/G)GGCTG utr-variant-3-prime
rs76228406 -- 35,755,789(+) ACGCG(C/G)GCCAC reference, missense
rs137940999 -- 35,755,101(+) GAGGG(C/T)TGTCT utr-variant-3-prime
rs140361660 -- 35,755,813(+) TTCGC(C/T)CACCA missense, reference
rs141923354 -- 35,756,107(+) CCTCT(C/T)CCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB6 Gene

Variant ID Type Subtype PubMed ID
dgv3852n71 CNV Loss 21882294
dgv3853n71 CNV Loss 21882294
nsv911636 CNV Loss 21882294
nsv819381 CNV Gain 19587683

Relevant External Links for HSPB6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB6 Gene

Disorders for HSPB6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HSPB6 Gene in MalaCards »

(3) Diseases for HSPB6 Gene

(8) Novoseek inferred disease relationships for HSPB6 Gene

Disease -log(P) Hits PubMed IDs
shock 76 35
cerebral amyloid angiopathy 73.9 1
vasospasm 52.3 3
senile plaques 43.4 1
brain diseases 38.9 1

Relevant External Links for HSPB6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSPB6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HSPB6 Gene

Publications for HSPB6 Gene

  1. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. (PMID: 18790732) Nicolaou P. … Kranias E.G. (J. Biol. Chem. 2008) 3 23 48
  2. Some properties of human small heat shock protein Hsp20 (HspB6). (PMID: 14717697) Bukach O.V. … Gusev N.B. (Eur. J. Biochem. 2004) 2 3 23
  3. Crystal structures of alpha-crystallin domain dimers of alphaB- crystallin and Hsp20. (PMID: 19646995) Bagneris C. … Slingsby C. (J. Mol. Biol. 2009) 3 23
  4. Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. (PMID: 18787533) Lopes L.B. … Brophy C.M. (J. Invest. Dermatol. 2009) 3 23
  5. Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy. (PMID: 18755793) Tyson E.K. … Read M. (Endocrinology 2008) 3 23

Products for HSPB6 Gene

Sources for HSPB6 Gene

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