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HSPB6 Gene

protein-coding   GIFtS: 55
GCID: GC19M036245

Heat Shock Protein, Alpha-Crystallin-Related, B6

  See HSPB6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Protein, Alpha-Crystallin-Related, B61 2     Epididymis Luminal Protein 552
Heat Shock 20 KDa-Like Protein P202 3     Heat Shock Protein Beta-62
HEL552     HspB63
Hsp202     HSP205

External Ids:    HGNC: 265111   Entrez Gene: 1263932   Ensembl: ENSG000000047767   OMIM: 6106955   UniProtKB: O145583   

Export aliases for HSPB6 gene to outside databases

Previous GC identifers: GC19M040938 GC19M040939 GC19M032750


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPB6 Gene:
This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation.
(provided by RefSeq, Jan 2012)

GeneCards Summary for HSPB6 Gene:
HSPB6 (heat shock protein, alpha-crystallin-related, B6) is a protein-coding gene. Diseases associated with HSPB6 include hereditary cerebral hemorrhage with amyloidosis, and cerebral amyloid angiopathy. GO annotations related to this gene include structural constituent of eye lens and protein homodimerization activity. An important paralog of this gene is HSPB1.

Gene Wiki entry for HSPB6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPB6 gene promoter:
         GATA-3   GCNF   GATA-2   GATA-1   POU2F1   COMP1   POU2F1a   FOXO4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPB6 promoter sequence
   Search Chromatin IP Primers for HSPB6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.13

HSPB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036245:  view genomic region     (about GC identifiers)

Start:
36,245,469 bp from pter      End:
36,248,980 bp from pter
Size:
3,512 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558 (See protein sequence)
Recommended Name: Heat shock protein beta-6  
Size: 160 amino acids; 17136 Da
Subunit: Homodimer (By similarity)
Secondary accessions: O14551 Q6NVI3 Q96MG9

Explore the universe of human proteins at neXtProt for HSPB6: NX_O14558

Explore proteomics data for HSPB6 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSPB6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653218.1  
    ENSEMBL proteins: 
     ENSP00000468057   ENSP00000467169   ENSP00000004982  

    HSPB6 Human Recombinant Protein Products:

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    Novus Biologicals HSPB6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPB6
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSPB6 

     
    antibodies-online proteins for HSPB6 (8 products) 

     
    antibodies-online peptides for HSPB6

    HSPB6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPB6
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    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HSPB6
    antibodies-online antibodies for HSPB6 (58 products) 

    HSPB6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HSPB6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSPB6 
    antibodies-online kits for HSPB6 (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSPB: Heat shock proteins / HSPB

    4 InterPro protein domains:
     IPR002068 a-crystallin/Hsp20_dom
     IPR008978 HSP20-like_chaperone
     IPR001436 Alpha-crystallin/HSP
     IPR003090 Alpha-crystallin_N

    Graphical View of Domain Structure for InterPro Entry O14558

    ProtoNet protein and cluster: O14558

    1 Blocks protein domain: IPB002068 Heat shock protein Hsp20

    UniProtKB/Swiss-Prot: HSPB6_HUMAN, O14558
    Similarity: Belongs to the small heat shock protein (HSP20) family


    Find genes that share domains with HSPB6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005212structural constituent of eye lens IEA--
    GO:0005515protein binding IPI16225851
    GO:0042803protein homodimerization activity ISS--
         
    Find genes that share ontologies with HSPB6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HSPB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPB6:
    hsa-mir-320a (MIRT004508)

    Block miRNA regulation of human, mouse, rat HSPB6 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HSPB6:
    hsa-miR-3618 hsa-miR-25* hsa-miR-149 hsa-miR-193a-5p hsa-miR-3126-3p hsa-miR-3652 hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHSPB6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPB6
    Predesigned siRNA for gene silencing in human, mouse, rat HSPB6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HSPB6 (NM_144617)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPB6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSPB6_HUMAN, O14558: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19464326
    GO:0005737cytoplasm IDA19464326

    Find genes that share ontologies with HSPB6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPB6: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPB6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for HSPB6 (O145581, 2, 3 ENSP000000049824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-8007683 MINT-8006832 I2D: score=2 STRING: ENSP00000306330
    HSPB8Q9UJY11, 3, ENSP000002819384EBI-739095,EBI-739074 I2D: score=2 STRING: ENSP00000281938
    CRYABP025113I2D: score=1 
    HSPB1P047923I2D: score=1 
    HSPA4ENSP000003029614STRING: ENSP00000302961
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006937regulation of muscle contraction IEA--
    GO:0006950response to stress IEA--

    Find genes that share ontologies with HSPB6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPB6

    5 Novoseek inferred chemical compound relationships for HSPB6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 33.1 7 9408240 (2), 10037721 (2), 17993590 (1), 18755793 (1)
    oxygen 0 1 10484413 (1)
    nitric oxide 0 1 15832944 (1)
    calcium 0 1 10658928 (1)
    serine 0 3 15218470 (1), 15598710 (1)



    Find genes that share compounds with HSPB6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPB6 gene: 
    NM_144617.2  

    Unigene Cluster for HSPB6:

    Heat shock protein, alpha-crystallin-related, B6
    Hs.534538  [show with all ESTs]
    Unigene Representative Sequence: NM_144617
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592984 ENST00000587965 ENST00000004982(uc002obn.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat HSPB6 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate HSPB6:
    hsa-miR-3618 hsa-miR-25* hsa-miR-149 hsa-miR-193a-5p hsa-miR-3126-3p hsa-miR-3652 hsa-miR-664*
    SwitchGear 3'UTR luciferase reporter plasmidHSPB6 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPB6
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    Primer
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    OriGene qPCR primer pairs and template standards for HSPB6
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPB6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPB6
      QuantiTect SYBR Green Assays in human, mouse, rat HSPB6
      QuantiFast Probe-based Assays in human, mouse, rat HSPB6

    Additional mRNA sequence: 

    AJ278121.1 AK056951.1 AK297852.1 AK300695.1 BC068046.1 

    11 DOTS entries:

    DT.100788513  DT.99980087  DT.216531  DT.100788516  DT.121488831  DT.121488806  DT.100788515  DT.87046426 
    DT.121488786  DT.121488848  DT.97844490 

    Selected AceView cDNA sequences (see all 207):

    AI720539 AJ712017 F31452 BI837440 R79117 AI093511 NM_144617 CN481632 
    CA393792 BC068046 AI583430 R75610 F31966 AI042145 BM790027 CR618274 
    BQ022051 F30902 AI933014 BM694413 AJ278121 AI692843 AI612800 AK056951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSPB6 Expression
    About this image


    HSPB6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Fibroblasts
             Detroit 551
    HSPB6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPB6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534538
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPB6: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HSPB6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspb61 , 5 heat shock protein, alpha-crystallin-related, B61, 5 82.64(n)1
    90.28(a)1
      7 (18.56 cM)5
    2439121  NM_001012401.21  NP_001012401.11 
     305521785 
    lizard
    (Anolis carolinensis)
    Reptilia HSPB66
    heat shock protein, alpha-crystallin-related, B6
    57(a)
    1 ↔ 1
    GL343276.1(1462581-1471512)
    zebrafish
    (Danio rerio)
    Actinopterygii hspb66
    heat shock protein, alpha-crystallin-related, b6
    37(a)
    many ↔ many
    15(36257981-36260993) ENSDARG00000077236


    ENSEMBL Gene Tree for HSPB6 (if available)
    TreeFam Gene Tree for HSPB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPB6 gene
    HSPB12  CRYAA2  CRYAB2  HSPB22  HSPB82  HSPB2-C11orf522  HSPB32  
    5 SIMAP similar genes for HSPB6 using alignment to 2 protein entries:     HSPB6_HUMAN (see all proteins):
    CRYAA    CRYAB    HSPB2    HSPB8    HSPB3

    Find genes that share paralogs with HSPB6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPB6 (see all 19)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379409991,2
    --36404715(+) GAGGGC/TTGTCT 1 -- ut310--------
    rs1901352781,2
    --36404885(+) GTGCTA/GGTAGG 1 -- ut310--------
    rs1490529271,2
    --36404945(+) TGTGAC/GAGCGA 1 -- ut310--------
    rs1430629371,2
    --36405078(+) GATCGG/TCTTTA 1 -- ut310--------
    rs115490301,2
    C,F--36405131(-) GGAGGG/CGGCTG 1 -- ut31 ese35Minor allele frequency- C:0.12NA WA EA 362
    rs2003587541,2
    --36405267(+) ACGGTA/GGAACT 2 H Y mis10--------
    rs762284061,2
    C--36405403(-) ACGCGC/GGCCAC 2 R G mis10--------
    rs1403616601,2
    C,F--36405427(+) TTCGCC/TCACCA 2 S G mis11Minor allele frequency- T:0.00NA 2952
    rs1503611271,2
    C,F--36405432(+) CCACCA/GCCTTG 2 A V mis11Minor allele frequency- G:0.00NA 3008
    rs1482236291,2
    C--36405695(+) CCTCCC/TCCTGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSPB6 (36245469 - 36248980 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HSPB6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3853n71CNV Loss21882294
    dgv3852n71CNV Loss21882294
    nsv911636CNV Loss21882294
    nsv819381CNV Gain19587683

    Human Gene Mutation Database (HGMD): HSPB6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPB6
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPB6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610695    OMIM disorders: --

    3 diseases for HSPB6:    
    About MalaCards
    hereditary cerebral hemorrhage with amyloidosis    cerebral amyloid angiopathy    keloids


    Find genes that share disorders with HSPB6           About GenesLikeMe

    8 Novoseek inferred disease relationships for HSPB6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 76 48 14717697 (3), 16038604 (3), 19100870 (3), 17109079 (2) (see all 26)
    cerebral amyloid angiopathy 73.9 1 16635482 (1)
    vasospasm 52.3 3 15349104 (2), 15829720 (1)
    senile plaques 43.4 1 16635482 (1)
    brain diseases 38.9 1 16635482 (1)
    alzheimers disease 30.7 1 16635482 (1)
    thrombosis 4.75 1 15349104 (1)
    ischemia 0 6 19850943 (6), 16099377 (1)

    Genetic Association Database (GAD): HSPB6
    Human Genome Epidemiology (HuGE) Navigator: HSPB6 (1 document)

    Export disorders for HSPB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPB6 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with HSPB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Some properties of human small heat shock protein Hsp20 (HspB6). (PubMed id 14717697)1, 3, 9 Bukach O.V....Gusev N.B. (Eur. J. Biochem. 2004)
    2. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. (PubMed id 18790732)1, 4, 9 Nicolaou P....Kranias E.G. (J. Biol. Chem. 2008)
    3. HSPB7 is a SC35 speckle resident small heat shock protein. (PubMed id 19464326)1, 2 Vos M.J.... Kampinga H.H. (Biochim. Biophys. Acta 2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PubMed id 12820654)1, 3 KappAc G....de Jong W.W. (amp 2003)
    8. Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. (PubMed id 8195168)1, 2 Kato K.... Asano T. (J. Biol. Chem. 1994)
    9. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. (PubMed id 19850943)1, 9 Qian J....Kranias E.G. (Circ. Res. 2009)
    10. Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. (PubMed id 17109079)1, 9 Chernik I.S....Gusev N.B. (Mol. Cell. Biochem. 2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126393 HGNC: 26511 AceView: HSPB6 Ensembl:ENSG00000004776 euGenes: HUgn126393
    ECgene: HSPB6 H-InvDB: HSPB6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPB6 Pharmacogenomics, SNPs, Pathways

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