Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPB3 Gene

Aliases for HSPB3 Gene

  • Heat Shock 27kDa Protein 3 2 3
  • HSPL27 3 4 6
  • Heat Shock 17 KDa Protein 3 4
  • Protein 3 3 4
  • HSP 17 3 4
  • DHMN2C 3 6
  • HMN2C 3 6
  • Heat Shock 27kD Protein 3 2
  • Heat Shock Protein Beta-3 3
  • HSP27 4
  • HspB3 4

External Ids for HSPB3 Gene

Previous GeneCards Identifiers for HSPB3 Gene

  • GC05P053915
  • GC05P055181
  • GC05P053721
  • GC05P053767
  • GC05P053787
  • GC05P050725

Summaries for HSPB3 Gene

Entrez Gene Summary for HSPB3 Gene

  • This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep 2010]

GeneCards Summary for HSPB3 Gene

HSPB3 (Heat Shock 27kDa Protein 3) is a Protein Coding gene. Diseases associated with HSPB3 include neuronopathy, distal hereditary motor, type iic and distal hereditary motor neuropathy, type ii. Among its related pathways are VEGF Signaling Pathway. An important paralog of this gene is CRYAA.

UniProtKB/Swiss-Prot for HSPB3 Gene

  • Inhibitor of actin polymerization

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB3 Gene

Genomics for HSPB3 Gene

Regulatory Elements for HSPB3 Gene

Genomic Location for HSPB3 Gene

54,455,601 bp from pter
54,456,384 bp from pter
784 bases
Plus strand

Genomic View for HSPB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB3 Gene

Proteins for HSPB3 Gene

  • Protein details for HSPB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for HSPB3 Gene

    150 amino acids
    Molecular mass:
    16966 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPB3 Gene

Proteomics data for HSPB3 Gene at MOPED

Post-translational modifications for HSPB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPB3 Gene

Domains for HSPB3 Gene

Gene Families for HSPB3 Gene

  • HSPB :Heat shock proteins / HSPB

Protein Domains for HSPB3 Gene

Suggested Antigen Peptide Sequences for HSPB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q12988
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB3: view

Function for HSPB3 Gene

Molecular function for HSPB3 Gene

GENATLAS Biochemistry:
heat shock protein 3
UniProtKB/Swiss-Prot Function:
Inhibitor of actin polymerization

Phenotypes for HSPB3 Gene

GenomeRNAi human phenotypes for HSPB3:
genes like me logo Genes that share phenotypes with HSPB3: view

Animal Model Products

miRNA for HSPB3 Gene

miRTarBase miRNAs that target HSPB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPB3 Gene

Localization for HSPB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB3 Gene

Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock.

Subcellular locations from

Jensen Localization Image for HSPB3 Gene COMPARTMENTS Subcellular localization image for HSPB3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
genes like me logo Genes that share ontologies with HSPB3: view

Pathways for HSPB3 Gene

SuperPathways for HSPB3 Gene

Superpath Contained pathways
1 VEGF Signaling Pathway
genes like me logo Genes that share pathways with HSPB3: view

Pathways by source for HSPB3 Gene

1 Sino Biological pathway for HSPB3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSPB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 8972725
GO:0008219 cell death --
genes like me logo Genes that share ontologies with HSPB3: view

Compounds for HSPB3 Gene

(8) ApexBio Compounds for HSPB3 Gene

Compound Action Cas Number
AT13387 Hsp90 inhibitor [912999-49-6]
BIIB021 "Hsp90 inhibitor,selective and competitive" [848695-25-0]
CH5138303 [959763-06-5]
Geldanamycin "Hsp90 inhibitor,potent and specific" [30562-34-6]
HSP990 (NVP-HSP990) [934343-74-5]
NMS-E973 "Hsp90 inhibitor,potent and selective" [1253584-84-7]
VER-49009 [558640-51-0]
VER-50589 [747413-08-7]
genes like me logo Genes that share compounds with HSPB3: view

Transcripts for HSPB3 Gene

mRNA/cDNA for HSPB3 Gene

(37) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPB3 Gene

Heat shock 27kDa protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB3 Gene

No ASD Table

Relevant External Links for HSPB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB3 Gene

mRNA expression in normal human tissues for HSPB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPB3 Gene

This gene is overexpressed in Heart - Left Ventricle (21.5), Heart - Atrial Appendage (15.7), and Muscle - Skeletal (8.3).

Protein differential expression in normal tissues for HSPB3 Gene

This gene is overexpressed in Tonsil (33.7), Fetal heart (17.2), and Heart (16.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSPB3 Gene

SOURCE GeneReport for Unigene cluster for HSPB3 Gene Hs.41707

genes like me logo Genes that share expressions with HSPB3: view

Expression partners for HSPB3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HSPB3 Gene

Orthologs for HSPB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB3 35
  • 86.58 (n)
  • 87.92 (a)
HSPB3 36
  • 87 (a)
(Canis familiaris)
Mammalia HSPB3 35
  • 89.11 (n)
  • 90 (a)
HSPB3 36
  • 90 (a)
(Mus musculus)
Mammalia Hspb3 35
  • 84.89 (n)
  • 88 (a)
Hspb3 16
Hspb3 36
  • 86 (a)
(Pan troglodytes)
Mammalia HSPB3 35
  • 99.33 (n)
  • 100 (a)
HSPB3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hspb3 35
  • 86.89 (n)
  • 88.67 (a)
(Ornithorhynchus anatinus)
Mammalia HSPB3 36
  • 68 (a)
(Gallus gallus)
Aves HSPB3 35
  • 67.12 (n)
  • 68.03 (a)
HSPB3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia HSPB3 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb3 35
  • 61.43 (n)
  • 59.29 (a)
(Danio rerio)
Actinopterygii hspb3 35
  • 58.58 (n)
  • 56.62 (a)
hspb3 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13133 36
  • 14 (a)
CG14207 36
  • 18 (a)
CG4461 36
  • 15 (a)
CG7409 36
  • 19 (a)
Hsp22 36
  • 14 (a)
Hsp23 36
  • 19 (a)
Hsp26 36
  • 18 (a)
Hsp27 36
  • 15 (a)
Hsp67Ba 36
  • 7 (a)
Hsp67Bc 36
  • 16 (a)
l(2)efl 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea F08H9.3 36
  • 17 (a)
F08H9.4 36
  • 19 (a)
hsp-12.1 36
  • 21 (a)
hsp-12.2 36
  • 27 (a)
hsp-12.3 36
  • 25 (a)
hsp-12.6 36
  • 25 (a)
hsp-16.1 36
  • 19 (a)
hsp-16.11 36
  • 19 (a)
hsp-16.2 36
  • 18 (a)
hsp-16.41 36
  • 15 (a)
hsp-16.48 36
  • 17 (a)
hsp-16.49 36
  • 17 (a)
hsp-17 36
  • 16 (a)
hsp-25 36
  • 14 (a)
hsp-43 36
  • 7 (a)
sip-1 36
  • 16 (a)
Y55F3BR.6 36
  • 16 (a)
Species with no ortholog for HSPB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPB3 Gene

Gene Tree for HSPB3 (if available)
Gene Tree for HSPB3 (if available)

Paralogs for HSPB3 Gene

Paralogs for HSPB3 Gene

Selected SIMAP similar genes for HSPB3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB3: view

Variants for HSPB3 Gene

Sequence variations from dbSNP and Humsavar for HSPB3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7699 -- 54,456,071(+) TGGCT(A/C/G)CTGAT synonymous-codon, reference
rs7823 -- 54,456,158(+) GATGG(C/T)GTGGA synonymous-codon, reference
rs4276366 -- 54,453,792(+) GATGG(A/C)AGACG upstream-variant-2KB
rs4397090 -- 54,455,070(+) ACTGA(A/C)GTTCA upstream-variant-2KB
rs4502773 -- 54,453,840(+) AATCA(C/T)TTGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPB3 Gene

Variant ID Type Subtype PubMed ID
nsv880713 CNV Gain 21882294
dgv6067n71 CNV Gain 21882294
nsv881404 CNV Gain 21882294

Relevant External Links for HSPB3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB3 Gene

Disorders for HSPB3 Gene

(1) OMIM Diseases for HSPB3 Gene (604624)


  • Neuronopathy, distal hereditary motor, 2C (HMN2C) [MIM:613376]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269 PubMed:20142617}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with HSPB3: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HSPB3 Gene

Publications for HSPB3 Gene

  1. HspB3, the most deviating of the six known human small heat shock proteins. (PMID: 9858786) Boelens W.C. … de Jong W.W. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family -- HSPL27. (PMID: 8972725) Lam W.Y. … Waye M.M.Y. (Biochim. Biophys. Acta 1996) 2 3 4
  3. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos M.J. … Kampinga H.H. (Biochim. Biophys. Acta 2009) 3 4
  4. Mutant small heat shock protein B3 causes motor neuropathy: utility of a candidate gene approach. (PMID: 20142617) Kolb S.J. … Prior T.W. (Neurology 2010) 3 4
  5. Structural aspects and chaperone activity of human HspB3: role of the "C-terminal extension". (PMID: 22610661) Asthana A. … Rao C.h.M. (Cell Biochem. Biophys. 2012) 3

Products for HSPB3 Gene

Sources for HSPB3 Gene

Back to Top