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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPB3 Gene

protein-coding   GIFtS: 50
GCID: GC05P053787

heat shock 27kDa protein 3

(Previous name: heat shock 27kD protein 3 )
 Explore 7 diseases affiliated with
HSPB3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSPB3    

Aliases
for HSPB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock 27kDa Protein 31 2     HMN2C2 5
HSPL271 2 3 5     Heat Shock 27kD Protein 31
Heat Shock 17 KDa Protein2 3     Heat Shock Protein Beta-32
Protein 32 3     HSP273
HSP 172 3     HspB33
DHMN2C2 5     

External Ids:    HGNC: 52481   Entrez Gene: 89882   Ensembl: ENSG000001692717   OMIM: 6046245   UniProtKB: Q129883   

Export aliases for HSPB3 gene to outside databases

Previous GC identifers: GC05P053915 GC05P055181 GC05P053721 GC05P053767 GC05P050725


Summaries
for HSPB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSPB3:
This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal
dominant distal hereditary motor neuropathy type 2C.(provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: HSPB3_HUMAN, Q12988
Function: Inhibitor of actin polymerization




Genomic Views
for HSPB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPB3 gene promoter:
         Tal-1   MyoD   CUTL1   POU6F1 (c2)   Tal-1beta   NF-E2 p45   Meis-1b   E47   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

HSPB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P053787:  view genomic region     (about GC identifiers)

Start:
 53,751,445 bp from pter      End:
 53,752,207 bp from pter
Size:
 763 bases      Orientation:
 plus strand

Proteins
for HSPB3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HSPB3_HUMAN, Q12988 (See protein sequence)
Recommended Name: Heat shock protein beta-3  
Size: 150 amino acids; 16966 Da
Subcellular location: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock

Explore the universe of human proteins at neXtProt for HSPB3: NX_Q12988

HSPB3 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_006299.1  
ENSEMBL proteins: 
 ENSP00000303394  

Human Recombinant Protein Products: 
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OriGene Purified Protein: HSPB3
OriGene Protein Over-expression Lysate: HSPB3
OriGene Custom Protein Services for HSPB3 
GenScript Custom Purified and Recombinant Proteins Services for HSPB3
Novus Biologicals HSPB3 Proteins
Novus Biologicals HSPB3 Lysate
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for HSPB3
Uscn Proteins for HSPB3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA19464326
GO:0005737cytoplasm IDA19464326


HSPB3 for ontologies           About GeneDecksing



HSPB3 Antibody Products: 
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OriGene Custom Antibody Services for HSPB3 
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Novus Biologicals HSPB3 Antibody
Search for Antibodies for HSPB3 at Abcam  
Uscn Antibodies for HSPB3
Search ThermoFisher Antibodies for HSPB3

Assay Products for HSPB3: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
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GenScript Custom Assay Services for HSPB3
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for HSPB3

Protein Domains /
Families
for HSPB3 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HSPB3 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR002068 a-crystallin/Hsp20_dom
 IPR008978 HSP20-like_chaperone
 IPR001436 Alpha-crystallin/HSP

Graphical View of Domain Structure for InterPro Entry Q12988

ProtoNet protein and cluster: Q12988

1 Blocks protein family: IPB002068 Heat shock protein Hsp20

UniProtKB/Swiss-Prot: HSPB3_HUMAN, Q12988
Similarity: Belongs to the small heat shock protein (HSP20) family


Function
for HSPB3 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: HSPB3_HUMAN, Q12988
Function: Inhibitor of actin polymerization

     Genatlas biochemistry entry for HSPB3:
heat shock protein 3

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB3
1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB3:
hsa-miR-548c-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB3 (see all 7)
OriGene shRNA RFP: HSPB3
OriGene siRNA: HSPB3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB3

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for HSPB3

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: HSPB3 (NM_006308)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB3 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for HSPB3
Search LifeMap BioReagents cell lines for HSPB3

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB3

1 GenomeRNAi human phenotype for HSPB3:
 Increased cell number in G2M,  

Animal Models:
     1 MGI phenotypic allele for Hspb3 (no phenotypes)

HSPB3 for phenotypes           About GeneDecksing


Pathways & Interactions
for HSPB3 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPB3

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/28 Interacting proteins for HSPB3 (Q129882, 3 ENSP000003033944) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
NSMFQ6X4W12, 3, ENSP000003605304MINT-64103 I2D: score=4 STRING: ENSP00000360530
ANP32AP396872, 3MINT-64099 I2D: score=5 
BBOX1O759362, 3MINT-64098 I2D: score=5 
MED31Q9Y3C72, 3MINT-64112 I2D: score=5 
MED8Q96G252, 3MINT-64108 I2D: score=5 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006986response to unfolded protein TAS9858786
GO:0008219cell death IEA--


HSPB3 for ontologies           About GeneDecksing



Drugs & Compounds
for HSPB3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPB3
Search CenterWatch for drugs/clinical trials and news about HSPB3 

Transcripts
for HSPB3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for HSPB3 gene: 
NM_006308.2  

Unigene Cluster for HSPB3:

Heat shock 27kDa protein 3
Hs.41707  [show with all ESTs]
Unigene Representative Sequence: NM_006308
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000302005(uc003jph.2)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB3
1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB3:
hsa-miR-548c-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPB3 (see all 7)
OriGene shRNA RFP: HSPB3
OriGene siRNA: HSPB3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPB3
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: HSPB3 (NM_006308)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPB3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB3 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB3
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB3
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB3

Additional cDNA sequence: 

AK314215.1 BC126272.1 BC132869.1 CR450314.1 U15590.1 Y17782.1 

2 DOTS entries:

DT.314824  DT.120848739 

24/37 AceView cDNA sequences (see all 37):

AI204315 CR450314 BM719542 AA136048 BX106905 AI275037 BF002760 BM930611 
AA476830 AA429090 AI333690 AA426507 NM_006308 U15590 Y17782 BP347482 
W21483 W21042 AI224915 N74099 AA126678 N88299 N74672 AA649552 

GeneLoc Exon Structure


Expression
for HSPB3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

HSPB3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells 
NameCategory
PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
Beating cell clusters (Spontaneous differen...)
HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

See HSPB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPB3

SOURCE GeneReport for Unigene cluster: Hs.41707
    SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB3: 
          Cellular Stress Responses in human mouse rat
          Heat Shock Proteins & Chaperones in human mouse rat

Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPB3
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPB3
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPB3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPB3
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB3

Orthologs
for HSPB3 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for HSPB3 gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Hspb31 , 5 heat shock protein 31, 5 84.89(n)1
88(a)1		   13 (64.01 cM)5
565341  NM_019960.21  NP_064344.11 
 1136628965 
chicken
(Gallus gallus)		 Aves HSPB31 heat shock 27kDa protein 3 67.12(n)
68.03(a)		   431593  XM_001231557.1  XP_001231558.1 
lizard
(Anolis carolinensis)		 Reptilia HSPB36
 --
 63(a)
 1 ↔ 1
 2(2909694-2910128)
zebrafish
(Danio rerio)		 Actinopterygii hspb31 heat shock protein, alpha-crystallin-related, b3 58.09(n)
56.62(a)		   568180  NM_001099452.1  NP_001092922.1 
worm
(Caenorhabditis elegans)		 Secernentea hsp-436
hsp-12.36
(see all 7)		 Heat Shock Protein family member (hsp-12.3)
(see all 7)		 8(a)
27(a)
(see all 7)		 many → 1
many → 1
(see all 7)		 X(6233113-6235505)
IV(9444771-9445307)


ENSEMBL Gene Tree for HSPB3 (if available)
TreeFam Gene Tree for HSPB3 (if available) 

Paralogs
for HSPB3 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HSPB3 gene
CRYAA2  HSPB12  CRYAB2  HSPB2-C11orf522  HSPB82  HSPB22  HSPB62  
5 SIMAP similar genes for HSPB3 using alignment to 2 protein entries:     HSPB3_HUMAN (see all proteins):
CRYAA    HSPB1    CRYAB    HSPB2    HSPB6

HSPB3 for paralogs           About GeneDecksing



Genomic Variants
for HSPB3 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/85 NCBI SNPs in HSPB3 are shown (see all 85)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 5 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1393820181,2
C,Fpathogenic50725613(+) TTGAGG/TCACCT 2 R S mis12Minor allele frequency- T:0.00NA EU 5859
rs788872871,2
F,--50723734(+) AAAAAT/AAAATA 1 -- us2k11Minor allele frequency- A:0.11NA 120
rs77241881,2
C,F,A,H,--50723911(+) ACAAAG/TCTTTC 1 -- us2k16Minor allele frequency- T:0.03NS EA WA 538
rs727620921,2
C,F,--50724096(+) AAAAAC/AAATCA 1 -- us2k11Minor allele frequency- A:0.11NA 120
rs358371971,2
C--50724237(+) GTCTC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs43970901,2
F,H,--50724872(+) ACTGAA/CGTTCA 1 -- us2k1 tfbs34Minor allele frequency- C:0.01NS EA 418
rs48658331,2
--50725239(+) ATACCA/GTTTTC 1 -- us2k10--------
rs114035061,2
C--50725358(+) ATGCAA/-CTGGG 1 -- us2k11Minor allele frequency- -:0.00NA 2
rs2022283081,2
C--50725584(-) GAAGGA/CAAAAA 1 -- ut510--------
rs1467108881,2
--53749480(+) TGGGCA/GCAGTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HSPB3 (53751445 - 53752207 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for HSPB3: --
Human Gene Mutation Database (HGMD): HSPB3

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB3
DNA2.0 Custom Variant and Variant Library Synthesis for HSPB3

Disorders / Diseases
for HSPB3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
HSPB3 for disorders           About GeneDecksing

OMIM gene information: 604624   
OMIM disorders: 613376  
UniProtKB/Swiss-Prot: HSPB3_HUMAN, Q12988
  • Defects in HSPB3 are the cause of distal hereditary motor neuronopathy type 2C (HMN2C) [MIM:613376]. It is a
    • neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular
    disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory
    deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome
    in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the
    anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal
    muscles of the lower limbs and/or to the distal upper limbs

    7 diseases for HSPB3:    About MalaCards
    distal hereditary motor neuropathy    inclusion body myositis    motor neuronopathy    muscular atrophy
    myositis    neuropathy    hermaphroditism


    Export disorders for HSPB3 gene to outside databases

    Publications
    for HSPB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPB3 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with HSPB3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HspB3, the most deviating of the six known human small heat shock proteins. (PubMed id 9858786)1, 2, 3, 9 Boelens W.C.... de Jong W.W. (1998)
    2. Isolation and characterization of a human heart cDNA encoding a new member of the small heat shock protein family -- HSPL27. (PubMed id 8972725)1, 2, 3 Lam W.Y....Waye M.M.Y. (1996)
    3. Mutant small heat shock protein B3 causes motor neuro pathy: utility of a candidate gene approach. (PubMed id 20142617)1, 2 Kolb S.J....Prior T.W. (2010)
    4. HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)1, 2 Vos M.J....Kampinga H.H. (2009)
    5. Structural aspects and chaperone activity of human Hsp B3: role of the 'C-terminal extension'. (PubMed id 22610661)1 Asthana A....Rao C.h.M. (2012)
    6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    7. Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. (PubMed id 16225851)1 Fontaine J.M....Welsh M.J. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Muscle develops a specific form of small heat shock protein complex composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation. (PubMed id 10625651)1 Sugiyama Y....Ohno S. (2000)
    10. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. (PubMed id 12820654)9 KappAc G....de Jong W.W. (2003)

    External Searches for HSPB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSPB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8988 HGNC: 5248 AceView: HSPB3 Ensembl:ENSG00000169271 euGenes: HUgn8988
    ECgene: HSPB3 H-InvDB: HSPB3

    Other Databases showing HSPB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSPB3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPB3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSPB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSPB3 gene:
    Search GeneIP for patents involving HSPB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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