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Aliases for HSPB2-C11orf52 Gene

Subcategory (RNA class) for HSPB2-C11orf52 Gene


Quality Score for this RNA gene is


Aliases for HSPB2-C11orf52 Gene

  • HSPB2-C11orf52 Readthrough (NMD Candidate) 2 3 5

External Ids for HSPB2-C11orf52 Gene

Previous GeneCards Identifiers for HSPB2-C11orf52 Gene

  • GC11U901862
  • GC11P111785

Summaries for HSPB2-C11orf52 Gene

Entrez Gene Summary for HSPB2-C11orf52 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring heat shock 27kDa protein 2 (HSPB2) and chromosome 11 open reading frame 52 (C11orf52) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) based on the use of the supported HSPB2 translational start codon, and it is therefore unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

GeneCards Summary for HSPB2-C11orf52 Gene

HSPB2-C11orf52 (HSPB2-C11orf52 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. Diseases associated with HSPB2-C11orf52 include Neuropathy, Congenital Hypomyelinating. GO annotations related to this gene include enzyme activator activity. An important paralog of this gene is HSPB2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB2-C11orf52 Gene

Genomics for HSPB2-C11orf52 Gene

Regulatory Elements for HSPB2-C11orf52 Gene

Enhancers for HSPB2-C11orf52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +27.3 27329 11.8 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PPP2R1B SDHD C11orf52 HSPB2-C11orf52 HSPB2 TIMM8B FDXACB1 C11orf1 ALG9 C11orf57
GH11G111974 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +64.3 64259 5.0 PKNOX1 KLF17 FEZF1 RAD21 GLIS2 GATA2 ELK1 SCRT2 FOS EGR2 C11orf52 PPP2R1B CRYAB HSPB2-C11orf52 HSPB2 DIXDC1 SDHD SIK2 ENSG00000255286 ENSG00000255334
GH11G111981 1.4 Ensembl ENCODE dbSUPER 11.5 +70.2 70166 2.9 HDAC1 FOXA2 ARNT WRNIP1 ARID4B RAD21 YY1 ZNF766 CREM REST RNA5SP351 DIXDC1 CRYAB C11orf52 HSPB2 HSPB2-C11orf52 PPP2R1B ENSG00000255334 ENSG00000255286
GH11G111870 1 ENCODE 10.6 -41.4 -41414 2.2 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 PPP2R1B DIXDC1 HSPB2 HSPB2-C11orf52 C11orf52 CRYAB C11orf57 PIH1D2 ALG9 GC11P111865
GH11G112128 1 Ensembl ENCODE 9.3 +216.3 216347 2.2 KLF1 NFIB JUN KLF17 FOSL1 GATA3 ZBTB48 FOS PRDM10 TCF7L2 BCO2 IL18 TEX12 ENSG00000254638 SDHD TIMM8B PIH1D2 C11orf57 CRYAB HSPB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPB2-C11orf52 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB2-C11orf52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044928 164 601 HDGF ZNF263 POLR2A NFXL1

Genomic Location for HSPB2-C11orf52 Gene

111,912,736 bp from pter
111,926,871 bp from pter
14,136 bases
Plus strand

Genomic View for HSPB2-C11orf52 Gene

Genes around HSPB2-C11orf52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB2-C11orf52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB2-C11orf52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB2-C11orf52 Gene

Proteins for HSPB2-C11orf52 Gene

  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Heat shock 27kDa protein 2, isoform CRA_a
    Protein Accession:

    Protein attributes for HSPB2-C11orf52 Gene

    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    No Data Available
  • Protein details for HSPB2-C11orf52 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    HSPB2-C11orf52 readthrough (NMD candidate)
    Protein Accession:

    Protein attributes for HSPB2-C11orf52 Gene

    52 amino acids
    Molecular mass:
    5934 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPB2-C11orf52 Gene

Protein Expression for HSPB2-C11orf52 Gene

Post-translational modifications for HSPB2-C11orf52 Gene

No Post-translational modifications

Other Protein References for HSPB2-C11orf52 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HSPB2-C11orf52 Gene

Domains & Families for HSPB2-C11orf52 Gene

Protein Domains for HSPB2-C11orf52 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HSPB2-C11orf52: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HSPB2-C11orf52 Gene

Function for HSPB2-C11orf52 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPB2-C11orf52 Gene

Localization for HSPB2-C11orf52 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HSPB2-C11orf52 Gene

Pathways & Interactions for HSPB2-C11orf52 Gene

SuperPathways for HSPB2-C11orf52 Gene

No Data Available

Interacting Proteins for HSPB2-C11orf52 Gene

Gene Ontology (GO) - Biological Process for HSPB2-C11orf52 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSPB2-C11orf52 Gene

Drugs & Compounds for HSPB2-C11orf52 Gene

No Compound Related Data Available

Transcripts for HSPB2-C11orf52 Gene

mRNA/cDNA for HSPB2-C11orf52 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2-C11orf52 Gene

No ASD Table

Relevant External Links for HSPB2-C11orf52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB2-C11orf52 Gene

Protein differential expression in normal tissues from HIPED for HSPB2-C11orf52 Gene

This gene is overexpressed in Fetal heart (26.4), Tonsil (20.0), and Heart (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for HSPB2-C11orf52 Gene

Protein tissue co-expression partners for HSPB2-C11orf52 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB2-C11orf52 Gene

Orthologs for HSPB2-C11orf52 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2-C11orf52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
(Bos Taurus)
Mammalia HSPB2 35
  • 98 (a)
(Mus musculus)
Mammalia Hspb2 35
  • 97 (a)
(Canis familiaris)
Mammalia -- 35
  • 96 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 90 (a)
(Gallus gallus)
Aves HSPB2 35
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
(Danio rerio)
Actinopterygii hspb2 35
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)efl 35
  • 28 (a)
CG7409 35
  • 25 (a)
Hsp23 35
  • 25 (a)
Hsp27 35
  • 23 (a)
Hsp22 35
  • 21 (a)
Hsp26 35
  • 21 (a)
Hsp67Bc 35
  • 21 (a)
CG4461 35
  • 20 (a)
CG14207 35
  • 19 (a)
CG13133 35
  • 18 (a)
Hsp67Ba 35
  • 11 (a)
(Caenorhabditis elegans)
Secernentea hsp-12.2 35
  • 30 (a)
F08H9.4 35
  • 29 (a)
hsp-12.1 35
  • 28 (a)
hsp-12.6 35
  • 26 (a)
hsp-16.1 35
  • 25 (a)
hsp-16.11 35
  • 25 (a)
hsp-16.2 35
  • 25 (a)
hsp-16.48 35
  • 24 (a)
hsp-16.49 35
  • 24 (a)
hsp-16.41 35
  • 23 (a)
hsp-17 35
  • 23 (a)
hsp-12.3 35
  • 22 (a)
Y55F3BR.6 35
  • 22 (a)
F08H9.3 35
  • 20 (a)
sip-1 35
  • 19 (a)
hsp-25 35
  • 17 (a)
hsp-43 35
  • 9 (a)
Species where no ortholog for HSPB2-C11orf52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPB2-C11orf52 Gene

Gene Tree for HSPB2-C11orf52 (if available)
Gene Tree for HSPB2-C11orf52 (if available)

Paralogs for HSPB2-C11orf52 Gene

Paralogs for HSPB2-C11orf52 Gene

genes like me logo Genes that share paralogs with HSPB2-C11orf52: view

Variants for HSPB2-C11orf52 Gene

Sequence variations from dbSNP and Humsavar for HSPB2-C11orf52 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs281865141 Pathogenic 111,911,665(-) TCCCC(-/C)AGCCG upstream-variant-2KB, reference, frameshift-variant
rs387907337 Pathogenic 111,911,667(-) ACTCC(C/T)CCAGC upstream-variant-2KB, reference, missense
rs387907338 Pathogenic 111,911,559(-) TCCTG(C/T)GGGCA upstream-variant-2KB, reference, missense
rs397516686 Likely pathogenic 111,911,722(-) ACCAT(A/G)GACAT upstream-variant-2KB, reference, missense
rs376222434 Likely benign 111,911,745(+) GTGAG(A/G)GGTCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPB2-C11orf52 Gene

Variant ID Type Subtype PubMed ID
nsv1070987 CNV deletion 25765185

Relevant External Links for HSPB2-C11orf52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSPB2-C11orf52 Gene

Disorders for HSPB2-C11orf52 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPB2-C11orf52 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuropathy, congenital hypomyelinating
  • dejerine-sottas disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPB2-C11orf52

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB2-C11orf52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB2-C11orf52 Gene

Publications for HSPB2-C11orf52 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for HSPB2-C11orf52 Gene

Sources for HSPB2-C11orf52 Gene

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