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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPB2-C11orf52 Gene

protein-coding   GIFtS: 24
GCID: GC11P111785

HSPB2-C11orf52 Readthrough (NMD Candidate)

  Search for HSPB2-C11orf52
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
HSPB2-C11orf52 Readthrough (NMD Candidate)1 2
HspB23
MKBP3
DMPK-Binding Protein3

External Ids:    HGNC: 419961   Entrez Gene: 1005280192   Ensembl: ENSG000002544457   UniProtKB: Q160823   
ORGUL members:         
NONCODE14:n410509      

Export aliases for HSPB2-C11orf52 gene to outside databases

Previous GC identifer: GC11U901862


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPB2-C11orf52 Gene:
This locus represents naturally occurring read-through transcription between the neighboring heat shock 27kDa
protein 2 (HSPB2) and chromosome 11 open reading frame 52 (C11orf52) genes. The read-through transcript is a
candidate for nonsense-mediated mRNA decay (NMD) based on the use of the supported HSPB2 translational start
codon, and it is therefore unlikely to produce a protein product. (provided by RefSeq, Dec 2010)

GeneCards Summary for HSPB2-C11orf52 Gene: 
HSPB2-C11orf52 (HSPB2-C11orf52 readthrough (NMD candidate)) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is HSPB1.

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
Function: May regulate the kinase DMPK




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HSPB2-C11orf52
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HSPB2-C11orf52

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB2-C11orf52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q23.1

HSPB2-C11orf52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB2-C11orf52 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111785:  view genomic region     (about GC identifiers)

Start:
111,783,460 bp from pter      End:
111,797,595 bp from pter
Size:
14,136 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082 (See protein sequence)
Recommended Name: Heat shock protein beta-2  
Size: 182 amino acids; 20233 Da
Subunit: Interacts with DMPK; may enhance its kinase activity
Subcellular location: Cytoplasm. Nucleus. Note=Localizes to nuclear foci
Secondary accessions: Q6I9U7

Explore the universe of human proteins at neXtProt for HSPB2-C11orf52: NX_Q16082

Explore proteomics data for HSPB2-C11orf52 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16082

  • HSPB2-C11orf52 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPB2-C11orf52 Protein Expression

    ENSEMBL proteins: 
     ENSP00000457706   ENSP00000455839  

    Human Recombinant Protein Products for HSPB2-C11orf52: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol ----

    HSPB2-C11orf52 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002068 a-crystallin/Hsp20_dom
     IPR008978 HSP20-like_chaperone
     IPR001436 Alpha-crystallin/HSP

    Graphical View of Domain Structure for InterPro Entry Q16082

    ProtoNet protein and cluster: Q16082

    1 Blocks protein domain: IPB002068 Heat shock protein Hsp20

    UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
    Similarity: Belongs to the small heat shock protein (HSP20) family


    HSPB2-C11orf52 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSPB2_HUMAN, Q16082
    Function: May regulate the kinase DMPK

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008047enzyme activator activity ----
         
    HSPB2-C11orf52 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPB2-C11orf52

    5/23 Interacting proteins for HSPB2-C11orf52 (Q160821, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB8Q9UJY11, 3EBI-739395,EBI-739074 I2D: score=2 
    CRYABP025112, 3MINT-8408048 I2D: score=1 
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein ----
    GO:0007525somatic muscle development ----
    GO:0009408response to heat ----
    GO:0043085positive regulation of catalytic activity ----

    HSPB2-C11orf52 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPB2-C11orf52 (HSPB2)

    Search CenterWatch for drugs/clinical trials and news about HSPB2-C11orf52 / HSPB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527616(uc009yyj.2) ENST00000534100(uc001pmh.3)
    miRNA
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    Inhib. RNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See HSPB2-C11orf52 Protein Expression from SPIRE MOPED and PaxDB

    UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
    Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens

        SABiosciences Custom PCR Arrays for HSPB2-C11orf52
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB2-C11orf52

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HSPB2-C11orf52 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HSPB26
    heat shock 27kDa protein 2
    57(a)
    1 → many
    24(6230556-6234006)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343521.1(16605-20289)
    zebrafish
    (Danio rerio)
    Actinopterygii hspb26
    heat shock protein, alpha-crystallin-related, b2
    51(a)
    1 → many
    5(58979568-58990471)
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)efl6
    lethal (2) essential for life
    26(a)
    1 → many
    2R(19572174-19573063)
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-12.26
    hsp-12.16
    (see all 4)
    Protein HSP-12.1, isoform a
    (see all 4)
    29(a)
    26(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    III(8138090-8139631)
    I(10581588-10582611)
            Species with no ortholog for HSPB2-C11orf52

    ENSEMBL Gene Tree for HSPB2-C11orf52 (if available)
    TreeFam Gene Tree for HSPB2-C11orf52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPB2-C11orf52 gene
    HSPB12  CRYAA2  CRYAB2  HSPB22  HSPB82  HSPB62  HSPB32  

    HSPB2-C11orf52 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/21 SNPs in HSPB2-C11orf52 are shown (see all 21)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735600271,2
    C--111785431(+) GAAGTG/TTCCAA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs42525931,2
    C,F--111785565(+) GAGGCC/TGAGGC 1 -- int13Minor allele frequency- T:0.05NS NA 182
    rs1461254171,2
    --111785603(+) GAGACC/TAGCCT 1 -- int10--------
    rs1882764921,2
    --111785648(+) ATAAAA/TATTAG 1 -- int10--------
    rs1389610831,2
    C--111785673(+) GCATGC/TCTGTA 1 -- int10--------
    rs1170312561,2
    F--111785817(+) TGAATT/GAAATT 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1817650111,2
    --111785885(+) CTATAA/GCTGCT 1 -- int10--------
    rs791233641,2
    F--111786342(+) GAAATT/ATGAAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1863475691,2
    --111786465(+) TTTCCA/GTGTTC 1 -- int10--------
    rs1427935771,2
    --111786545(+) CACTGA/CAGCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSPB2-C11orf52 (111783460 - 111797595 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPB2-C11orf52: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HSPB2-C11orf52
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPB2-C11orf52 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HSPB2-C11orf52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
    2. HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)2 Vos M.J....Kampinga H.H. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PubMed id 9490724)2 Suzuki A....Ohno S. (1998)
    6. Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner. (PubMed id 9344664)2 Iwaki A.... Fukumaki Y. (1997)
    7. Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics. (PubMed id 8227983)2 Elisei R.... Ludgate M. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100528019 HGNC: 41996 Ensembl:ENSG00000254445 euGenes: HUgn100528019 ECgene: HSPB2-C11orf52
    H-InvDB: HSPB2-C11orf52

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPB2-C11orf52 gene:
    Search GeneIP for patents involving HSPB2-C11orf52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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