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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPB2 Gene

protein-coding   GIFtS: 59
GCID: GC11P111782

Heat Shock 27kDa Protein 2

(Previous name: heat shock 27kD protein 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 27kDa Protein 21 2     LOH11CR1K2
MKBP2 3     Heat Shock Protein Beta-22
DMPK-Binding Protein2 3     Heat-Shock Protein Beta-22
Heat Shock 27kD Protein 21     HspB23
HSP272     

External Ids:    HGNC: 52471   Entrez Gene: 33162   Ensembl: ENSG000001702767   OMIM: 6021795   UniProtKB: Q160823   

Export aliases for HSPB2 gene to outside databases

Previous GC identifers: GC11P114136 GC11P113295 GC11P111817 GC11P111320 GC11P111321 GC11P111288 GC11P107707


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPB2 Gene:
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative
alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the
heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important
role in maintenance of muscle structure and function. (provided by RefSeq, Dec 2012)

GeneCards Summary for HSPB2 Gene: 
HSPB2 (heat shock 27kDa protein 2) is a protein-coding gene. Diseases associated with HSPB2 include corticobasal degeneration, and myotonic dystrophy, and among its related super-pathways are MAPK signaling pathway. GO annotations related to this gene include protein binding and enzyme activator activity. An important paralog of this gene is HSPB1.

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
Function: May regulate the kinase DMPK

Gene Wiki entry for HSPB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPB2 gene promoter:
         FOXI1   HFH-3   Max1   Sp1   NF-kappaB1   NF-kappaB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q23.1   HGNC cytogenetic band: 11q22-q23

HSPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P111782:  view genomic region     (about GC identifiers)

Start:
111,782,966 bp from pter      End:
111,789,574 bp from pter
Size:
6,609 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082 (See protein sequence)
Recommended Name: Heat shock protein beta-2  
Size: 182 amino acids; 20233 Da
Subunit: Interacts with DMPK; may enhance its kinase activity
Subcellular location: Cytoplasm. Nucleus. Note=Localizes to nuclear foci
Secondary accessions: Q6I9U7

Explore the universe of human proteins at neXtProt for HSPB2: NX_Q16082

Explore proteomics data for HSPB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16082

  • HSPB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPB2 Protein Expression
    REFSEQ proteins: NP_001532.1  
    ENSEMBL proteins: 
     ENSP00000302476   ENSP00000445585  

    Human Recombinant Protein Products for HSPB2: 
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    Novus Biologicals HSPB2 Protein
    Novus Biologicals HSPB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSPB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS9490724

    HSPB2 for ontologies           About GeneDecksing



    HSPB2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HSPB2 

    Assay Products for HSPB2: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSPB: Heat shock proteins / HSPB

    3 InterPro protein domains:
     IPR002068 a-crystallin/Hsp20_dom
     IPR008978 HSP20-like_chaperone
     IPR001436 Alpha-crystallin/HSP

    Graphical View of Domain Structure for InterPro Entry Q16082

    ProtoNet protein and cluster: Q16082

    1 Blocks protein domain: IPB002068 Heat shock protein Hsp20

    UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
    Similarity: Belongs to the small heat shock protein (HSP20) family


    HSPB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSPB2_HUMAN, Q16082
    Function: May regulate the kinase DMPK

         Genatlas biochemistry entry for HSPB2:
    heat shock protein 2,located near the 5' flanking region of the CRYAB gene in a head to orientation
    manner,expressed in muscle and heart,localized to the cross sections of individual myofibrils at the Z membrane
    as well as at the neuromuscular junction,complexing with HSPB3 during myogenic differentiation,binding and
    activating MDPK,may be involved in the pathogenesis of DM,not induced by heat shock,potentially involved in
    chaperone activity and maintenance of cytoskeletal network in muscle,alpha crystallin/small hsp family

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14594798
    GO:0008047enzyme activator activity TAS9490724
         
    HSPB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSPB2:
     Decreased nuclei size in G2M 

         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hspb2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  growth/size  immune system  mortality/aging  muscle 
     nervous system  skeleton  vision/eye 

    HSPB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cryab/Hspb2Cryab/tm1Wawr for HSPB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPB2 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB2:
    hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidHSPB2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3Proteoglycans in cancer
    Proteoglycans in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HSPB2
        MAPK signaling pathway



    2         Kegg Pathways  (Kegg details for HSPB2):
        Epstein-Barr virus infection
    Proteoglycans in cancer


    HSPB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/27 Interacting proteins for HSPB2 (Q160821, 2, 3 ENSP000003024764) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPB8Q9UJY11, 3, ENSP000002819384EBI-739395,EBI-739074 I2D: score=2 STRING: ENSP00000281938
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein NAS9344664
    GO:0007525somatic muscle development IEA--
    GO:0009408response to heat IEA--
    GO:0043085positive regulation of catalytic activity TAS9490724

    HSPB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPB2

    10/34 Novoseek inferred chemical compound relationships for HSPB2 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 56.1 11 10679516 (3), 10491224 (2), 17185631 (1), 18757417 (1) (see all 7)
    radicicol 47.3 3 17409432 (1), 15360086 (1)
    methylglyoxal 46.8 13 16615138 (5), 12226095 (3), 16969712 (1)
    17-(allylamino)-17-demethoxygeldanamycin 46 2 17409432 (2)
    pd 98,059 44.3 6 10679516 (2), 19675578 (1), 10491224 (1), 17185631 (1)
    anisomycin 30.1 3 9368070 (1), 10425226 (1)
    h2o2 28.1 9 8070680 (3), 16380078 (1), 9048659 (1), 8654367 (1) (see all 5)
    quercetin 25 6 17036391 (2), 12429348 (2), 19112469 (1)
    tunicamycin 19.1 2 15864808 (2)
    cisplatin 13.8 11 8824551 (5), 9222809 (2), 17276589 (1), 9205074 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPB2 gene: 
    NM_001541.3  

    Unigene Cluster for HSPB2:

    Heat shock 27kDa protein 2
    Hs.709660  [show with all ESTs]
    Unigene Representative Sequence: AB096250
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304298(uc001pmg.2) ENST00000537382

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB2:
    hsa-miR-629
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPB2
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    Additional mRNA sequence: 

    AB096250.1 BC109393.1 CR457408.1 D89617.1 S67070.1 

    3 DOTS entries:

    DT.456317  DT.97801394  DT.95159595 

    24/86 AceView cDNA sequences (see all 86):

    BQ102454 BQ016457 BI002577 BF058405 AI091682 BM670905 CA441936 AU100400 
    BU679692 BU738757 BX111808 BM713924 N29027 BE348443 NM_080659 AK057948 
    CD673301 AB096250 BI835428 BM676540 CK902836 BC008501 BE968503 BU628087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPB2 expression in normal human tissues (normalized intensities)      HSPB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAGCCTT
    HSPB2 Expression
    About this image


    HSPB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb/leg   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Fibroblast
             BH2 Dermal Fibroblasts   

    See HSPB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPB2

    SOURCE GeneReport for Unigene cluster: Hs.709660

    UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082
    Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB2: 
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HSPB2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspb21 , 5 heat shock protein 21, 5 91.03(n)1
    97.25(a)1
      9 (27.75 cM)5
    692531  NM_024441.31  NP_077761.31 
     507510725 
    chicken
    (Gallus gallus)
    Aves HSPB21 heat shock 27kDa protein 2 65.41(n)
    61.01(a)
      414136  NM_001001527.1  NP_001001527.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343521.1(16605-20289)
    zebrafish
    (Danio rerio)
    Actinopterygii hspb21 heat shock protein, alpha-crystallin-related, b2 56.94(n)
    53.42(a)
      550439  NM_001017744.1  NP_001017744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)efl6
    lethal (2) essential for life
    26(a)
    1 → many
    2R(19572174-19573063)
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-12.26
    hsp-12.16
    (see all 4)
    Protein HSP-12.1, isoform a
    (see all 4)
    29(a)
    26(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    III(8138090-8139631)
    I(10581588-10582611)


    ENSEMBL Gene Tree for HSPB2 (if available)
    TreeFam Gene Tree for HSPB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPB2 gene
    HSPB12  CRYAA2  CRYAB2  HSPB82  HSPB2-C11orf522  HSPB62  HSPB32  
    4 SIMAP similar genes for HSPB2 using alignment to 2 protein entries:     HSPB2_HUMAN (see all proteins):
    CRYAB    HSPB6    HSPB3    CRYAA

    HSPB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in HSPB2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0163164
    ----see VAR_0163162 G S mis40--------

    HapMap Linkage Disequilibrium report for HSPB2 (111782966 - 111789574 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPB2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPB2
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602179    OMIM disorders: --

    20/55 diseases for HSPB2 (see all 55):    About MalaCards
    corticobasal degeneration    myotonic dystrophy    fibrous histiocytoma    myofibrillar myopathy
    histiocytoma    diabetic neuropathy    paget's disease of bone    machado-joseph disease
    cerebral amyloid angiopathy    oral squamous cell carcinoma    contact dermatitis    amyotrophic lateral sclerosis
    lateral sclerosis    myopathy    dermatitis    ataxia telangiectasia
    astrocytoma    bronchiolitis    atherosclerosis    glioblastoma


    HSPB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/34 Novoseek inferred disease relationships for HSPB2 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 85.3 167 9490724 (3), 16505970 (3), 20065497 (3), 18089808 (3) (see all 99)
    neurodegenerative diseases 41.9 6 12401949 (1), 17467701 (1), 19249290 (1), 11699557 (1) (see all 6)
    neurofibrillary tangles 28.5 2 15132984 (1), 18061943 (1)
    myotonic dystrophy 27.5 8 10355872 (2), 9490724 (1), 12820655 (1)
    cell damage 22.6 1 17036391 (1)
    atherosclerotic plaque 21.4 8 16574891 (4), 15249501 (2)
    vasospasm 17.7 1 15978441 (1)
    amyotrophic lateral sclerosis 17.5 1 17623484 (1)
    myopathy 17.3 3 17467701 (1), 10362540 (1), 15978589 (1)
    malignant fibrous histiocytoma 15.6 2 8169976 (1), 1313743 (1)

    Genetic Association Database (GAD): HSPB2
    Human Genome Epidemiology (HuGE) Navigator: HSPB2 (2 documents)

    Export disorders for HSPB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPB2 gene, integrated from 9 sources (see all 285):
    (articles sorted by number of sources associating them with HSPB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PubMed id 9490724)1, 2, 3, 9 Suzuki A....Ohno S. (1998)
    2. Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner. (PubMed id 9344664)1, 2, 3 Iwaki A.... Fukumaki Y. (1997)
    3. Analysis of multiple candidate genes in association w ith phenotypes of multiple sclerosis. (PubMed id 20378664)1, 4 Sombekke M.H....Uitdehaag B.M. (2010)
    4. HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)1, 2 Vos M.J....Kampinga H.H. (2009)
    5. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics. (PubMed id 8227983)1, 2 Elisei R.... Ludgate M. (1993)
    8. HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. (PubMed id 12897149)1, 9 Parcellier A....Garrido C. (2003)
    9. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. (PubMed id 20101233)1, 9 Andrieu C....Rocchi P. (2010)
    10. Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines. (PubMed id 12700631)1, 9 Yonekura N....Fujii N. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3316 HGNC: 5247 AceView: HSPB2andMGC14839 Ensembl:ENSG00000170276 euGenes: HUgn3316
    ECgene: HSPB2 Kegg: 3316 H-InvDB: HSPB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPB2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspb2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPB2 gene:
    Search GeneIP for patents involving HSPB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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