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Aliases for HSPB2 Gene

Aliases for HSPB2 Gene

  • Heat Shock Protein Family B (Small) Member 2 2 3 5
  • Heat Shock 27kDa Protein 2 2 3
  • DMPK-Binding Protein 3 4
  • MKBP 3 4
  • Heat Shock 27kD Protein 2 2
  • Heat Shock Protein Beta-2 3
  • Heat-Shock Protein Beta-2 3
  • LOH11CR1K 3
  • Hs.78846 3
  • HSP27 3
  • HspB2 4

External Ids for HSPB2 Gene

Previous GeneCards Identifiers for HSPB2 Gene

  • GC11P114136
  • GC11P113295
  • GC11P111817
  • GC11P111320
  • GC11P111321
  • GC11P111288
  • GC11P111782
  • GC11P107707

Summaries for HSPB2 Gene

Entrez Gene Summary for HSPB2 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSPB2 Gene

HSPB2 (Heat Shock Protein Family B (Small) Member 2) is a Protein Coding gene. Diseases associated with HSPB2 include Neuromuscular Disease and Corticobasal Degeneration. Among its related pathways are Proteoglycans in cancer and IL-1 signaling pathway. GO annotations related to this gene include enzyme activator activity. An important paralog of this gene is HSPB2-C11orf52.

UniProtKB/Swiss-Prot for HSPB2 Gene

  • May regulate the kinase DMPK.

Gene Wiki entry for HSPB2 Gene

Additional gene information for HSPB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB2 Gene

Genomics for HSPB2 Gene

Regulatory Elements for HSPB2 Gene

Enhancers for HSPB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H111934 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +27.8 27823 11.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PPP2R1B SDHD C11orf52 HSPB2 HSPB2-C11orf52 TIMM8B FDXACB1 C11orf1 ALG9 NKAPD1
GH11H111974 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11 +64.8 64753 5 PKNOX1 KLF17 FEZF1 RAD21 GLIS2 ELK1 SCRT2 EGR2 ELK4 SP3 C11orf52 PPP2R1B CRYAB HSPB2-C11orf52 HSPB2 DIXDC1 SDHD SIK2 ENSG00000255286 ENSG00000255334
GH11H111981 1.4 Ensembl ENCODE dbSUPER 11.5 +70.7 70660 2.9 HDAC1 FOXA2 ARNT ARID4B RAD21 YY1 ZNF766 ATF7 CREM REST RNA5SP351 DIXDC1 CRYAB C11orf52 HSPB2-C11orf52 HSPB2 PPP2R1B ENSG00000255334 ENSG00000255286
GH11H111870 1 ENCODE 10.6 -40.9 -40920 2.2 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF766 PPP2R1B DIXDC1 HSPB2 HSPB2-C11orf52 C11orf52 CRYAB NKAPD1 PIH1D2 ALG9 GC11P111865
GH11H112128 1 Ensembl ENCODE 9.3 +216.8 216841 2.2 STAT1 KLF1 NFIB JUN CEBPB KLF17 FOSL1 NFIC JUND GATA3 BCO2 IL18 TEX12 ENSG00000254638 TIMM8B SDHD NKAPD1 PIH1D2 HSPB2 HSPB2-C11orf52
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPB2 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044928 658 601 HDGF POLR2A NFXL1

Genomic Locations for HSPB2 Gene

Genomic Locations for HSPB2 Gene
1,852 bases
Plus strand

Genomic View for HSPB2 Gene

Genes around HSPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB2 Gene

Proteins for HSPB2 Gene

  • Protein details for HSPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-2
    Protein Accession:
    Secondary Accessions:
    • Q6I9U7

    Protein attributes for HSPB2 Gene

    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    • Interacts with DMPK; may enhance its kinase activity.

neXtProt entry for HSPB2 Gene

Post-translational modifications for HSPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPB2 Gene

Domains & Families for HSPB2 Gene

Gene Families for HSPB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for HSPB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB2: view

Function for HSPB2 Gene

Molecular function for HSPB2 Gene

GENATLAS Biochemistry:
heat shock protein 2,located near the 5 flanking region of the CRYAB gene in a head to orientation manner,expressed in muscle and heart,localized to the cross sections of individual myofibrils at the Z membrane as well as at the neuromuscular junction,complexing with HSPB3 during myogenic differentiation,binding and activating MDPK,may be involved in the pathogenesis of DM,not induced by heat shock,potentially involved in chaperone activity and maintenance of cytoskeletal network in muscle,alpha crystallin/small hsp family
UniProtKB/Swiss-Prot Function:
May regulate the kinase DMPK.

Gene Ontology (GO) - Molecular Function for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14594798
GO:0008047 enzyme activator activity TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view
genes like me logo Genes that share phenotypes with HSPB2: view

Animal Models for HSPB2 Gene

MGI Knock Outs for HSPB2:

Animal Model Products

miRNA for HSPB2 Gene

miRTarBase miRNAs that target HSPB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPB2 Gene

Localization for HSPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB2 Gene

Cytoplasm. Nucleus. Note=Localizes to nuclear foci.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPB2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19464326
GO:0005737 cytoplasm IDA,IEA 19464326
GO:0005829 cytosol TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSPB2 Gene

Pathways & Interactions for HSPB2 Gene

genes like me logo Genes that share pathways with HSPB2: view

Pathways by source for HSPB2 Gene

2 BioSystems pathways for HSPB2 Gene
2 KEGG pathways for HSPB2 Gene

Gene Ontology (GO) - Biological Process for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 9344664
GO:0007525 somatic muscle development IEA --
GO:0009408 response to heat IEA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with HSPB2: view

No data available for SIGNOR curated interactions for HSPB2 Gene

Drugs & Compounds for HSPB2 Gene

(22) Drugs for HSPB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for HSPB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPB2: view

Transcripts for HSPB2 Gene

mRNA/cDNA for HSPB2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPB2 Gene

Heat shock 27kDa protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2 Gene

No ASD Table

Relevant External Links for HSPB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPB2 Gene

This gene is overexpressed in Fetal heart (25.0), Tonsil (18.9), and Heart (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPB2 Gene

Protein tissue co-expression partners for HSPB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPB2 Gene:


SOURCE GeneReport for Unigene cluster for HSPB2 Gene:


mRNA Expression by UniProt/SwissProt for HSPB2 Gene:

Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens.

Evidence on tissue expression from TISSUES for HSPB2 Gene

  • Muscle(4.5)
  • Heart(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with HSPB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB2 Gene

Orthologs for HSPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
(Canis familiaris)
Mammalia -- 34
  • 96 (a)
HSPB2 33
  • 90.84 (n)
(Rattus norvegicus)
Mammalia Hspb2 33
  • 92.53 (n)
(Mus musculus)
Mammalia Hspb2 33 16 34
  • 91.52 (n)
(Bos Taurus)
Mammalia HSPB2 34 33
  • 91.11 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
(Gallus gallus)
Aves HSPB2 33 34
  • 65.41 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb2 33
  • 56.73 (n)
(Danio rerio)
Actinopterygii hspb2 33 34
  • 56.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)efl 34
  • 28 (a)
Hsp23 34
  • 25 (a)
CG7409 34
  • 25 (a)
Hsp27 34
  • 23 (a)
Hsp22 34
  • 21 (a)
Hsp26 34
  • 21 (a)
Hsp67Bc 34
  • 21 (a)
CG4461 34
  • 20 (a)
CG14207 34
  • 19 (a)
CG13133 34
  • 18 (a)
Hsp67Ba 34
  • 11 (a)
(Caenorhabditis elegans)
Secernentea hsp-12.2 34
  • 30 (a)
F08H9.4 34
  • 29 (a)
hsp-12.1 34
  • 28 (a)
hsp-12.6 34
  • 26 (a)
hsp-16.1 34
  • 25 (a)
hsp-16.11 34
  • 25 (a)
hsp-16.2 34
  • 25 (a)
hsp-16.48 34
  • 24 (a)
hsp-16.49 34
  • 24 (a)
hsp-16.41 34
  • 23 (a)
hsp-17 34
  • 23 (a)
hsp-12.3 34
  • 22 (a)
Y55F3BR.6 34
  • 22 (a)
F08H9.3 34
  • 20 (a)
sip-1 34
  • 19 (a)
hsp-25 34
  • 17 (a)
hsp-43 34
  • 9 (a)
Species where no ortholog for HSPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPB2 Gene

Gene Tree for HSPB2 (if available)
Gene Tree for HSPB2 (if available)

Paralogs for HSPB2 Gene

(4) SIMAP similar genes for HSPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB2: view

Variants for HSPB2 Gene

Sequence variations from dbSNP and Humsavar for HSPB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs281865141 Pathogenic 111,911,665(-) TCCCC(-/C)AGCCG upstream-variant-2KB, reference, frameshift-variant
rs387907337 Pathogenic 111,911,667(-) ACTCC(C/T)CCAGC upstream-variant-2KB, reference, missense
rs387907338 Pathogenic 111,911,559(-) TCCTG(C/T)GGGCA upstream-variant-2KB, reference, missense
rs397516686 Likely pathogenic 111,911,722(-) ACCAT(A/G)GACAT upstream-variant-2KB, reference, missense
rs376222434 Likely benign 111,911,745(+) GTGAG(A/G)GGTCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPB2 Gene

Variant ID Type Subtype PubMed ID
nsv1070987 CNV deletion 25765185

Variation tolerance for HSPB2 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB2 Gene

Disorders for HSPB2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HSPB2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuromuscular disease
  • neuromuscular diseases
corticobasal degeneration
  • cbgd
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease, type 2i
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HSPB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB2 Gene

Publications for HSPB2 Gene

  1. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PMID: 9490724) Suzuki A … Ohno S (The Journal of cell biology 1998) 2 3 4 22 60
  2. Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner. (PMID: 9344664) Iwaki A … Fukumaki Y (Genomics 1997) 2 3 4 60
  3. Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. (PMID: 20101233) Andrieu C … Rocchi P (Oncogene 2010) 3 22 60
  4. Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. (PMID: 20378664) Sombekke MH … Uitdehaag BM (Multiple sclerosis (Houndmills, Basingstoke, England) 2010) 3 45 60
  5. HSPB7 is a SC35 speckle resident small heat shock protein. (PMID: 19464326) Vos MJ … Kampinga HH (Biochimica et biophysica acta 2009) 3 4 60

Products for HSPB2 Gene

Sources for HSPB2 Gene

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