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Aliases for HSPB2 Gene

Aliases for HSPB2 Gene

  • Heat Shock 27kDa Protein 2 2 3
  • DMPK-Binding Protein 3 4
  • MKBP 3 4
  • Heat Shock 27kD Protein 2 2
  • Heat-Shock Protein Beta-2 3
  • LOH11CR1K 3
  • Hs.78846 3
  • HSP27 3
  • HspB2 4

External Ids for HSPB2 Gene

Previous GeneCards Identifiers for HSPB2 Gene

  • GC11P114136
  • GC11P113295
  • GC11P111817
  • GC11P111320
  • GC11P111321
  • GC11P111288
  • GC11P111782
  • GC11P107707

Summaries for HSPB2 Gene

Entrez Gene Summary for HSPB2 Gene

  • The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSPB2 Gene

HSPB2 (Heat Shock 27kDa Protein 2) is a Protein Coding gene. Diseases associated with HSPB2 include corticobasal degeneration and cisplatin toxicity. Among its related pathways are Epstein-Barr virus infection and Proteoglycans in cancer. GO annotations related to this gene include enzyme activator activity. An important paralog of this gene is CRYAA.

UniProtKB/Swiss-Prot for HSPB2 Gene

  • May regulate the kinase DMPK.

Gene Wiki entry for HSPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB2 Gene

Genomics for HSPB2 Gene

Regulatory Elements for HSPB2 Gene

Genomic Location for HSPB2 Gene

111,912,242 bp from pter
111,914,093 bp from pter
1,852 bases
Plus strand

Genomic View for HSPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HSPB2 Gene

Proteins for HSPB2 Gene

  • Protein details for HSPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock protein beta-2
    Protein Accession:
    Secondary Accessions:
    • Q6I9U7

    Protein attributes for HSPB2 Gene

    182 amino acids
    Molecular mass:
    20233 Da
    Quaternary structure:
    • Interacts with DMPK; may enhance its kinase activity.

neXtProt entry for HSPB2 Gene

Proteomics data for HSPB2 Gene at MOPED

Post-translational modifications for HSPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPB2 Gene

Domains & Families for HSPB2 Gene

Gene Families for HSPB2 Gene

Protein Domains for HSPB2 Gene

Suggested Antigen Peptide Sequences for HSPB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
genes like me logo Genes that share domains with HSPB2: view

Function for HSPB2 Gene

Molecular function for HSPB2 Gene

GENATLAS Biochemistry:
heat shock protein 2,located near the 5 flanking region of the CRYAB gene in a head to orientation manner,expressed in muscle and heart,localized to the cross sections of individual myofibrils at the Z membrane as well as at the neuromuscular junction,complexing with HSPB3 during myogenic differentiation,binding and activating MDPK,may be involved in the pathogenesis of DM,not induced by heat shock,potentially involved in chaperone activity and maintenance of cytoskeletal network in muscle,alpha crystallin/small hsp family
UniProtKB/Swiss-Prot Function:
May regulate the kinase DMPK.

Gene Ontology (GO) - Molecular Function for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14594798
GO:0008047 enzyme activator activity TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view
genes like me logo Genes that share phenotypes with HSPB2: view

Animal Models for HSPB2 Gene

MGI Knock Outs for HSPB2:

Animal Model Products

miRNA for HSPB2 Gene

miRTarBase miRNAs that target HSPB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HSPB2 Gene

Localization for HSPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB2 Gene

Cytoplasm. Nucleus. Note=Localizes to nuclear foci.

Gene Ontology (GO) - Cellular Components for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19464326
GO:0005737 cytoplasm IDA 19464326
GO:0005829 cytosol TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view

No data available for Subcellular locations from COMPARTMENTS for HSPB2 Gene

Pathways & Interactions for HSPB2 Gene

genes like me logo Genes that share pathways with HSPB2: view

Pathways by source for HSPB2 Gene

1 Sino Biological pathway for HSPB2 Gene
1 BioSystems pathway for HSPB2 Gene
2 KEGG pathways for HSPB2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 9344664
GO:0043085 positive regulation of catalytic activity TAS 9490724
genes like me logo Genes that share ontologies with HSPB2: view

No data available for SIGNOR curated interactions for HSPB2 Gene

Drugs & Compounds for HSPB2 Gene

(17) Drugs for HSPB2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Iron Approved Pharma 957
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 836
Acetylcholine Experimental Pharma Full agonist, Agonist 104

(17) Additional Compounds for HSPB2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
genes like me logo Genes that share compounds with HSPB2: view

Transcripts for HSPB2 Gene

mRNA/cDNA for HSPB2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(86) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPB2 Gene

Heat shock 27kDa protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB2 Gene

No ASD Table

Relevant External Links for HSPB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPB2 Gene

mRNA expression in normal human tissues for HSPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPB2 Gene

This gene is overexpressed in Fetal heart (25.0), Tonsil (18.9), and Heart (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB2 Gene

SOURCE GeneReport for Unigene cluster for HSPB2 Gene Hs.709660

mRNA Expression by UniProt/SwissProt for HSPB2 Gene

Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens
genes like me logo Genes that share expression patterns with HSPB2: view

Protein tissue co-expression partners for HSPB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HSPB2 Gene

Orthologs for HSPB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HSPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPB2 35
  • 91.11 (n)
  • 98.79 (a)
HSPB2 36
  • 98 (a)
(Canis familiaris)
Mammalia HSPB2 35
  • 90.84 (n)
  • 95.6 (a)
-- 36
  • 96 (a)
(Mus musculus)
Mammalia Hspb2 35
  • 91.52 (n)
  • 98.18 (a)
Hspb2 16
Hspb2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Hspb2 35
  • 92.53 (n)
  • 98.18 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
(Gallus gallus)
Aves HSPB2 35
  • 65.41 (n)
  • 61.01 (a)
HSPB2 36
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb2 35
  • 56.73 (n)
  • 60.87 (a)
(Danio rerio)
Actinopterygii hspb2 35
  • 56.94 (n)
  • 53.42 (a)
hspb2 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13133 36
  • 18 (a)
CG14207 36
  • 19 (a)
CG4461 36
  • 20 (a)
CG7409 36
  • 25 (a)
Hsp22 36
  • 21 (a)
Hsp23 36
  • 25 (a)
Hsp26 36
  • 21 (a)
Hsp27 36
  • 23 (a)
Hsp67Ba 36
  • 11 (a)
Hsp67Bc 36
  • 21 (a)
l(2)efl 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea F08H9.3 36
  • 20 (a)
F08H9.4 36
  • 29 (a)
hsp-12.1 36
  • 28 (a)
hsp-12.2 36
  • 30 (a)
hsp-12.3 36
  • 22 (a)
hsp-12.6 36
  • 26 (a)
hsp-16.1 36
  • 25 (a)
hsp-16.11 36
  • 25 (a)
hsp-16.2 36
  • 25 (a)
hsp-16.41 36
  • 23 (a)
hsp-16.48 36
  • 24 (a)
hsp-16.49 36
  • 24 (a)
hsp-17 36
  • 23 (a)
hsp-25 36
  • 17 (a)
hsp-43 36
  • 9 (a)
sip-1 36
  • 19 (a)
Y55F3BR.6 36
  • 22 (a)
Species with no ortholog for HSPB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPB2 Gene

Gene Tree for HSPB2 (if available)
Gene Tree for HSPB2 (if available)

Paralogs for HSPB2 Gene

Paralogs for HSPB2 Gene

(4) SIMAP similar genes for HSPB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPB2: view

Variants for HSPB2 Gene

Sequence variations from dbSNP and Humsavar for HSPB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_016316 -

Variation tolerance for HSPB2 Gene

Residual Variation Intolerance Score: 61.15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPB2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPB2 Gene

Disorders for HSPB2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSPB2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
corticobasal degeneration
  • cbgd
cisplatin toxicity
- elite association
Search HSPB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPB2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPB2 Gene

Publications for HSPB2 Gene

  1. MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PMID: 9490724) Suzuki A. … Ohno S. (J. Cell Biol. 1998) 2 23 67
  2. Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis. (PMID: 19540014) Zhuang H. … Hua Z.C. (Lung Cancer 2010) 23 67
  3. Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis. (PMID: 19879248) Lambrecht S. … Elewaut D. (Osteoarthr. Cartil. 2010) 23 67
  4. The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. (PMID: 20150973) Schwarz L. … Richter-Landsberg C. (Int J Cell Biol 2010) 23 67
  5. The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. (PMID: 19675578) Robitaille H. … Germain L. (J. Invest. Dermatol. 2010) 23 67

Products for HSPB2 Gene

Sources for HSPB2 Gene

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