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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPB2 Gene

protein-coding GIFtS: 59
GCID: GC11P111782

heat shock 27kDa protein 2

(Previous name: heat shock 27kD protein 2 )

Explore 62 diseases affiliated with
HSPB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 27kDa Protein 2¹ ²		LOH11CR1K²
MKBP¹ ² ³		Heat Shock Protein Beta-2²
DMPK-Binding Protein² ³		Heat-Shock Protein Beta-2²
Heat Shock 27kD Protein 2¹		HspB2³
HSP27²

External Ids:	HGNC: 5247¹	Entrez Gene: 3316²	Ensembl: ENSG00000170276⁷	OMIM: 602179⁵	UniProtKB: Q16082³

Export aliases for HSPB2 gene to outside databases

Previous GC identifers: GC11P114136 GC11P113295 GC11P111817 GC11P111320 GC11P111321 GC11P111288 GC11P107707

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPB2:

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative

alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart

and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in

maintenance of muscle structure and function. (provided by RefSeq, Dec 2012)

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082

Function: May regulate the kinase DMPK

Gene Wiki entry for HSPB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPB2 gene promoter:
FOXI1 HFH-3 Max1 Sp1 NF-kappaB1 NF-kappaB c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPB2 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q22-q23

HSPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPB2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P111782: view genomic region (about GC identifiers)

Start:	111,782,966 bp from pter	End:	111,789,574 bp from pter
Size:	6,609 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082 (See protein sequence)

Recommended Name: Heat shock protein beta-2

Size: 182 amino acids; 20233 Da

Subunit: Interacts with DMPK; may enhance its kinase activity

Subcellular location: Cytoplasm. Nucleus. Note=Localizes to nuclear foci

Secondary accessions: Q6I9U7

Explore the universe of human proteins at neXtProt for HSPB2: NX_Q16082

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16082

HSPB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001532.1

ENSEMBL proteins:

ENSP00000302476 ENSP00000445585

Human Recombinant Protein Products:

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	Uscn Proteins for HSPB2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	9490724

HSPB2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HSPB2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPB2 for domains About GeneDecksing

3 InterPro domains/families:

IPR002068 a-crystallin/Hsp20_dom

IPR008978 HSP20-like_chaperone

IPR001436 Alpha-crystallin/HSP

Graphical View of Domain Structure for InterPro Entry Q16082

ProtoNet protein and cluster: Q16082

1 Blocks protein family: IPB002068 Heat shock protein Hsp20

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082

Similarity: Belongs to the small heat shock protein (HSP20) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082

Function: May regulate the kinase DMPK

Genatlas biochemistry entry for HSPB2:

heat shock protein 2,located near the 5' flanking region of the CRYAB gene in a head to orientation manner,expressed in

muscle and heart,localized to the cross sections of individual myofibrils at the Z membrane as well as at the

neuromuscular junction,complexing with HSPB3 during myogenic differentiation,binding and activating MDPK,may be

involved in the pathogenesis of DM,not induced by heat shock,potentially involved in chaperone activity and

maintenance of cytoskeletal network in muscle,alpha crystallin/small hsp family

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB2:
		hsa-miR-629
		SwitchGear 3'UTR luciferase reporter plasmid: HSPB2 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for HSPB2

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		Search LifeMap BioReagents cell lines for HSPB2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPB2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14594798
GO:0008047	enzyme activator activity	TAS	9490724

HSPB2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HSPB2:

Decreased nuclei size in G2M

Animal Models:
Mouse knock-out Cryab/Hspb2^{Cryab/tm1Wawr} for HSPB2
13 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hspb2):

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial
digestive/alimentary	growth/size	immune system	mortality/aging	muscle
nervous system	skeleton	vision/eye

HSPB2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MAPK signaling pathway

MAPK signaling pathway

1.00

1 BioSystems Pathway for HSPB2

MAPK signaling pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/21 Interacting proteins for HSPB2 (Q16082^{1, 2, 3} ENSP00000302476⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPB8	Q9UJY1¹^,³, ENSP00000281938⁴	EBI-739395,EBI-739074 I2D: score=2 STRING: ENSP00000281938
CRYAB	P02511²^,³, ENSP00000227251⁴	MINT-8408048 I2D: score=1 STRING: ENSP00000227251
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
CLK4	Q9HAZ1³, ENSP00000316948⁴	I2D: score=1 STRING: ENSP00000316948
MAPKAPK5	Q8IW41³, ENSP00000202788⁴	I2D: score=1 STRING: ENSP00000202788

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006986	response to unfolded protein	NAS	9344664
GO:0007525	somatic muscle development	IEA	--
GO:0009408	response to heat	IEA	--
GO:0043085	positive regulation of catalytic activity	TAS	9490724

HSPB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPB2
10/34 Novoseek chemical compound relationships for HSPB2 gene (see all 34) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sb 203580	56.1	11	10679516 (3), 10491224 (2), 17185631 (1), 18757417 (1) (see all 7)
radicicol	47.3	3	17409432 (1), 15360086 (1)
methylglyoxal	46.8	13	16615138 (5), 12226095 (3), 16969712 (1)
17-(allylamino)-17-demethoxygeldanamycin	46	2	17409432 (2)
pd 98,059	44.3	6	10679516 (2), 19675578 (1), 10491224 (1), 17185631 (1)
anisomycin	30.1	3	9368070 (1), 10425226 (1)
h2o2	28.1	9	8070680 (3), 16380078 (1), 9048659 (1), 8654367 (1) (see all 5)
quercetin	25	6	17036391 (2), 12429348 (2), 19112469 (1)
tunicamycin	19.1	2	15864808 (2)
cisplatin	13.8	11	8824551 (5), 9222809 (2), 17276589 (1), 9205074 (1)

Search CenterWatch for drugs/clinical trials and news about HSPB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPB2 gene:

NM_001541.3

Unigene Cluster for HSPB2:

Heat shock 27kDa protein 2

Hs.709660 [show with all ESTs]

Unigene Representative Sequence: AB096250

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000304298(uc001pmg.2) ENST00000537382

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPB2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HSPB2:
		hsa-miR-629
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Additional cDNA sequence:

AB096250.1 BC109393.1 CR457408.1 D89617.1 S67070.1

3 DOTS entries:

DT.456317 DT.97801394 DT.95159595

24/86 AceView cDNA sequences (see all 86):

BE348443 BM713924 BI002577 CD673301 AK057948 AB096250 BU738757 AI091682

BQ016457 BU679692 CA441936 AU100400 BM670905 BX111808 BF058405 CK902836

BC008501 N29027 BQ102454 BM676540 BI835428 NM_080659 BQ712347 CR457408

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATAGCCTT

About this image

HSPB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Limb

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPB2

SOURCE GeneReport for Unigene cluster: Hs.709660

UniProtKB/Swiss-Prot: HSPB2_HUMAN, Q16082

Tissue specificity: Expressed preferentially in skeletal muscle and heart but not in the lens

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPB2:

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HSPB2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSPB2¹	heat shock 27kDa protein 2	65.41(n) 61.01(a)		414136 NM_001001527.1 NP_001001527.1
lizard (Anolis carolinensis)	Reptilia	HSPB2⁶	--	59(a)	1 → many	GL343521.1(16679-20058)
zebrafish (Danio rerio)	Actinopterygii	hspb2¹	heat shock protein, alpha-crystallin-related, b2	56.94(n) 53.42(a)		550439 NM_001017744.1 NP_001017744.1
fruit fly (Drosophila melanogaster)	Insecta	l(2)efl⁶ CG7409⁶ (see all 9)	--	27(a) 25(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2R(19572174-19573063) 3L(7747509-7748268)

ENSEMBL Gene Tree for HSPB2 (if available)
TreeFam Gene Tree for HSPB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPB2 gene

CRYAA² HSPB1² CRYAB² HSPB2-C11orf52² HSPB8² HSPB6² HSPB3²

5 SIMAP similar genes for HSPB2 using alignment to 2 protein entries: HSPB2_HUMAN (see all proteins):

CRYAB HSPB6 HSPB3 CRYAA HSPB1

HSPB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141000255^1,2	C,F,	--	111784515(+)	`CTCGGG/AGTGGC`	3	/S /G	mis¹ int¹		1		NA	4552
rs45602839^1,2	F	--	111784535(+)	`GACACA/TGAGGT`	3	T	int¹ syn¹		1		NS	30
rs192172142^1,2	C,	--	111784570(+)	`CCCTGC/TGCCTC`	3	A V	int¹ mis¹		0	--	--	--	--
rs146155375^1,2	C,	--	111784602(+)	`AGGCAG/ACCATA`	3	/T /A	mis¹ int¹		1		NA	4230
rs189529671^1,2		--	111784770(+)	`TCATAA/GCCTTG`	2	--	ut3¹ int¹		0	--	--	--	--
rs4252590^1,2	C,F,H,	--	111784816(+)	`TCAGGG/ACCTTG`	2	--	ut3¹ int¹ ese³		14		NS EA NA	1206
rs117765764^1,2	F,	--	111784827(+)	`TTTGTA/GCTGCT`	2	--	int¹ ds500¹		1		NA	120
rs150183137^1,2		--	111784847(+)	`GTGGCC/TGGGAA`	2	--	ds500¹ int¹		0	--	--	--	--
rs181591659^1,2		--	111784893(+)	`GCTAGA/GCAAAA`	2	--	ds500¹ int¹		0	--	--	--	--
rs4252591^1,2	C,F,H,	--	111784923(+)	`CCCAAC/TGTCAT`	2	--	int¹ ds500¹		28		NS NA EA WA	3152

HapMap Linkage Disequilibrium report for HSPB2 (111782966 - 111789574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPB2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPB2

DNA2.0 Custom Variant and Variant Library Synthesis for HSPB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPB2 for disorders           About GeneDecksing

OMIM gene information: 602179    OMIM disorders: --

20/62 diseases for HSPB2 (see all 62):    About MalaCards

malignant fibrous histiocytoma machado-joseph disease fibrous histiocytoma cerebral amyloid angiopathy

amyotrophic lateral sclerosis myotonic dystrophy corticobasal degeneration lateral sclerosis

myofibrillar myopathy supranuclear palsy histiocytoma squamous cell carcinoma

contact dermatitis paget's disease of bone oral squamous cell carcinoma atrial fibrillation

esophageal squamous cell carcinoma atopic dermatitis brain injury ataxia telangiectasia

1 disease from the University of Copenhagen DISEASES database for HSPB2:

Cerebral amyloid angiopathy

10/34 Novoseek disease relationships for HSPB2 gene (see all 34) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	85.3	167	9490724 (3), 16505970 (3), 20065497 (3), 18089808 (3) (see all 99)
neurodegenerative diseases	41.9	6	12401949 (1), 17467701 (1), 19249290 (1), 11699557 (1) (see all 6)
neurofibrillary tangles	28.5	2	15132984 (1), 18061943 (1)
myotonic dystrophy	27.5	8	10355872 (2), 9490724 (1), 12820655 (1)
cell damage	22.6	1	17036391 (1)
atherosclerotic plaque	21.4	8	16574891 (4), 15249501 (2)
vasospasm	17.7	1	15978441 (1)
amyotrophic lateral sclerosis	17.5	1	17623484 (1)
myopathy	17.3	3	17467701 (1), 10362540 (1), 15978589 (1)
malignant fibrous histiocytoma	15.6	2	8169976 (1), 1313743 (1)

Human Genome Epidemiology (HuGE) Navigator: HSPB2 (2 documents)

Export disorders for HSPB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HSPB2 gene, integrated from 9 sources (see all 283):
(articles sorted by number of sources associating them with HSPB2)

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MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. (PubMed id 9490724)^{1, 2, 3, 9} Suzuki A....Ohno S. (1998)
Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner. (PubMed id 9344664)^{1, 2, 3} Iwaki A.... Fukumaki Y. (1997)
HSPB7 is a SC35 speckle resident small heat shock pro tein. (PubMed id 19464326)^{1, 2} Vos M.J....Kampinga H.H. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Muscle autoantigens in thyroid associated ophthalmopathy: the limits of molecular genetics. (PubMed id 8227983)^{1, 2} Elisei R.... Ludgate M. (1993)
HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. (PubMed id 12897149)^{1, 9} Parcellier A....Garrido C. (2003)
Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. (PubMed id 20101233)^{1, 9} Andrieu C....Rocchi P. (2010)
Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral squamous cell carcinoma lines. (PubMed id 12700631)^{1, 9} Yonekura N....Fujii N. (2003)
Small heat shock proteins Hsp27 or alphaB-crystallin and the protein components of neurofibrillary tangles: tau and neurofilaments. (PubMed id 18061943)^{1, 9} Bjorkdahl C....Pei J.J. (2008)
Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. (PubMed id 11926998)^{1, 9} Ito H....Kato K. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3316	HGNC: 5247	AceView: HSPB2andMGC14839	Ensembl:ENSG00000170276	euGenes: HUgn3316
ECgene: HSPB2	H-InvDB: HSPB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HSPB2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPB2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspb2/

Intellectual Property for HSPB2 gene
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Patent Information for HSPB2 gene:
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heat shock 27kDa protein 2

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