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Aliases for HSPB11 Gene

Aliases for HSPB11 Gene

  • Heat Shock Protein Family B (Small), Member 11 2 3
  • Heat Shock Protein Beta-11 3 4
  • Placental Protein 25 3 4
  • C1orf41 3 4
  • IFT25 3 4
  • PP25 3 4
  • Intraflagellar Transport 25 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 25 Homolog 3
  • Intraflagellar Transport 25 Homolog 3
  • Chromosome 1 Open Reading Frame 41 2
  • HSPCO34 3
  • Hspb11 4

External Ids for HSPB11 Gene

Previous HGNC Symbols for HSPB11 Gene

  • C1orf41

Previous GeneCards Identifiers for HSPB11 Gene

  • GC01M054159
  • GC01M054387
  • GC01M052502

Summaries for HSPB11 Gene

GeneCards Summary for HSPB11 Gene

HSPB11 (Heat Shock Protein Family B (Small), Member 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HSPB11 Gene

  • Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB11 Gene

Genomics for HSPB11 Gene

Regulatory Elements for HSPB11 Gene

Genomic Location for HSPB11 Gene

Start:
53,916,574 bp from pter
End:
53,946,302 bp from pter
Size:
29,729 bases
Orientation:
Minus strand

Genomic View for HSPB11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB11 Gene

Proteins for HSPB11 Gene

  • Protein details for HSPB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y547-IFT25_HUMAN
    Recommended name:
    Intraflagellar transport protein 25 homolog
    Protein Accession:
    Q9Y547
    Secondary Accessions:
    • A6NG57
    • D3DQ45
    • Q9Y684

    Protein attributes for HSPB11 Gene

    Size:
    144 amino acids
    Molecular mass:
    16297 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88 (By similarity).
    SequenceCaution:
    • Sequence=AAD43011.1; Type=Frameshift; Positions=77; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSPB11 Gene

neXtProt entry for HSPB11 Gene

Proteomics data for HSPB11 Gene at MOPED

Post-translational modifications for HSPB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB11 Gene

No data available for DME Specific Peptides for HSPB11 Gene

Domains for HSPB11 Gene

Gene Families for HSPB11 Gene

HGNC:
  • HSPB :Heat shock proteins / HSPB
  • IFT :Intraflagellar transport homologs

Protein Domains for HSPB11 Gene

Suggested Antigen Peptide Sequences for HSPB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y547

UniProtKB/Swiss-Prot:

IFT25_HUMAN :
  • Q9Y547
Family:
  • Belongs to the IFT25 family.
genes like me logo Genes that share domains with HSPB11: view

Function for HSPB11 Gene

Molecular function for HSPB11 Gene

UniProtKB/Swiss-Prot Function: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).

Gene Ontology (GO) - Molecular Function for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HSPB11: view
genes like me logo Genes that share phenotypes with HSPB11: view

Animal Model Products

CRISPR Products

miRNA for HSPB11 Gene

miRTarBase miRNAs that target HSPB11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPB11 Gene

Localization for HSPB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB11 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPB11 Gene COMPARTMENTS Subcellular localization image for HSPB11 gene
Compartment Confidence
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0005929 cilium --
GO:0030992 intraciliary transport particle B ISS --
GO:0070062 extracellular exosome IDA 23376485
GO:0072372 primary cilium TAS --
genes like me logo Genes that share ontologies with HSPB11: view

Pathways for HSPB11 Gene

SuperPathways for HSPB11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006950 response to stress --
GO:0006996 organelle organization TAS --
GO:0007155 cell adhesion --
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with HSPB11: view

No data available for Pathways by source for HSPB11 Gene

Transcripts for HSPB11 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPB11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HSPB11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - -
SP7:

Relevant External Links for HSPB11 Gene

GeneLoc Exon Structure for
HSPB11
ECgene alternative splicing isoforms for
HSPB11

Expression for HSPB11 Gene

mRNA expression in normal human tissues for HSPB11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB11 Gene

SOURCE GeneReport for Unigene cluster for HSPB11 Gene Hs.525462

mRNA Expression by UniProt/SwissProt for HSPB11 Gene

Q9Y547-IFT25_HUMAN
Tissue specificity: Detected in placenta.
genes like me logo Genes that share expressions with HSPB11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSPB11 Gene

Orthologs for HSPB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPB11 35
  • 99.77 (n)
  • 99.31 (a)
HSPB11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C3H1ORF41 36
  • 90 (a)
OneToOne
HSPB11 35
  • 90.44 (n)
  • 90.21 (a)
dog
(Canis familiaris)
Mammalia HSPB11 35
  • 91.08 (n)
  • 90.85 (a)
HSPB11 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspb11 35
  • 86.85 (n)
  • 85.92 (a)
Hspb11 16
Hspb11 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPB11 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPB11 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspb11 35
  • 86.62 (n)
  • 85.92 (a)
chicken
(Gallus gallus)
Aves HSPB11 35
  • 66.67 (n)
  • 65.22 (a)
lizard
(Anolis carolinensis)
Reptilia HSPB11 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb11 35
  • 61.48 (n)
  • 57.78 (a)
Str.541 35
zebrafish
(Danio rerio)
Actinopterygii HSPB11 36
  • 51 (a)
OneToOne
zgc:158640 35
  • 58.08 (n)
  • 50.76 (a)
Species with no ortholog for HSPB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB11 Gene

ENSEMBL:
Gene Tree for HSPB11 (if available)
TreeFam:
Gene Tree for HSPB11 (if available)

Paralogs for HSPB11 Gene

No data available for Paralogs for HSPB11 Gene

Variants for HSPB11 Gene

Sequence variations from dbSNP and Humsavar for HSPB11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs742389 -- 53,927,119(-) GCTTT(G/T)AGCTC intron-variant
rs2206342 -- 53,928,435(+) CAAGG(G/T)CTGTA reference, missense, intron-variant
rs3830768 -- 53,923,844(+) ATAGG(-/T)TTAAA intron-variant
rs7542738 -- 53,940,840(+) aagta(C/G)ctgag intron-variant
rs10047036 -- 53,923,527(+) ATCTC(A/G)CTTGT intron-variant

Relevant External Links for HSPB11 Gene

HapMap Linkage Disequilibrium report
HSPB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPB11 Gene

Disorders for HSPB11 Gene

No disorders were found for HSPB11 Gene.

No data available for UniProtKB/Swiss-Prot for HSPB11 Gene

Publications for HSPB11 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26). (PMID: 2018407) Bohn H. … Winckler W. (Arch. Gynecol. Obstet. 1991) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of mouse IFT complex B. (PMID: 19253336) Follit J.A. … Pazour G.J. (Cell Motil. Cytoskeleton 2009) 2 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for HSPB11 Gene

Sources for HSPB11 Gene

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