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Aliases for HSPB11 Gene

Aliases for HSPB11 Gene

  • Heat Shock Protein Family B (Small) Member 11 2 3 5
  • Heat Shock Protein Family B (Small), Member 11 2 3
  • Heat Shock Protein Beta-11 3 4
  • Placental Protein 25 3 4
  • C1orf41 3 4
  • IFT25 3 4
  • PP25 3 4
  • Intraflagellar Transport 25 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport 25 Homolog 3
  • Chromosome 1 Open Reading Frame 41 2
  • HSPCO34 3
  • Hspb11 4

External Ids for HSPB11 Gene

Previous HGNC Symbols for HSPB11 Gene

  • C1orf41

Previous GeneCards Identifiers for HSPB11 Gene

  • GC01M054159
  • GC01M054387
  • GC01M052502

Summaries for HSPB11 Gene

GeneCards Summary for HSPB11 Gene

HSPB11 (Heat Shock Protein Family B (Small) Member 11) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

UniProtKB/Swiss-Prot for HSPB11 Gene

  • Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB11 Gene

Genomics for HSPB11 Gene

Regulatory Elements for HSPB11 Gene

Enhancers for HSPB11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPB11 on UCSC Golden Path with GeneCards custom track

Promoters for HSPB11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPB11 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPB11 Gene

Chromosome:
1
Start:
53,916,574 bp from pter
End:
53,946,303 bp from pter
Size:
29,730 bases
Orientation:
Minus strand

Genomic View for HSPB11 Gene

Genes around HSPB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB11 Gene

Proteins for HSPB11 Gene

  • Protein details for HSPB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y547-IFT25_HUMAN
    Recommended name:
    Intraflagellar transport protein 25 homolog
    Protein Accession:
    Q9Y547
    Secondary Accessions:
    • A6NG57
    • D3DQ45
    • Q9Y684

    Protein attributes for HSPB11 Gene

    Size:
    144 amino acids
    Molecular mass:
    16297 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88 (By similarity).
    SequenceCaution:
    • Sequence=AAD43011.1; Type=Frameshift; Positions=77; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSPB11 Gene

neXtProt entry for HSPB11 Gene

Proteomics data for HSPB11 Gene at MOPED

Post-translational modifications for HSPB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPB11 Gene

No data available for DME Specific Peptides for HSPB11 Gene

Domains & Families for HSPB11 Gene

Protein Domains for HSPB11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y547

UniProtKB/Swiss-Prot:

IFT25_HUMAN :
  • Belongs to the IFT25 family.
Family:
  • Belongs to the IFT25 family.
genes like me logo Genes that share domains with HSPB11: view

Function for HSPB11 Gene

Molecular function for HSPB11 Gene

UniProtKB/Swiss-Prot Function:
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).
genes like me logo Genes that share phenotypes with HSPB11: view

Animal Models for HSPB11 Gene

MGI Knock Outs for HSPB11:

Animal Model Products

CRISPR Products

miRNA for HSPB11 Gene

miRTarBase miRNAs that target HSPB11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPB11 Gene

Localization for HSPB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB11 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPB11 Gene COMPARTMENTS Subcellular localization image for HSPB11 gene
Compartment Confidence
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030992 intraciliary transport particle B IEA,ISS --
GO:0097542 ciliary tip TAS --
genes like me logo Genes that share ontologies with HSPB11: view

Pathways & Interactions for HSPB11 Gene

genes like me logo Genes that share pathways with HSPB11: view

Pathways by source for HSPB11 Gene

Gene Ontology (GO) - Biological Process for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007224 smoothened signaling pathway IEA --
GO:0007507 heart development IEA --
GO:0070986 left/right axis specification IEA --
genes like me logo Genes that share ontologies with HSPB11: view

No data available for SIGNOR curated interactions for HSPB11 Gene

Drugs & Compounds for HSPB11 Gene

No Compound Related Data Available

Transcripts for HSPB11 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - -
SP7:

Relevant External Links for HSPB11 Gene

GeneLoc Exon Structure for
HSPB11
ECgene alternative splicing isoforms for
HSPB11

Expression for HSPB11 Gene

mRNA expression in normal human tissues for HSPB11 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPB11 Gene



SOURCE GeneReport for Unigene cluster for HSPB11 Gene Hs.525462

mRNA Expression by UniProt/SwissProt for HSPB11 Gene

Q9Y547-IFT25_HUMAN
Tissue specificity: Detected in placenta.
genes like me logo Genes that share expression patterns with HSPB11: view

Protein tissue co-expression partners for HSPB11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HSPB11 Gene

Orthologs for HSPB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPB11 35
  • 90.44 (n)
  • 90.21 (a)
C3H1ORF41 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPB11 35
  • 91.08 (n)
  • 90.85 (a)
HSPB11 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspb11 35
  • 86.85 (n)
  • 85.92 (a)
Hspb11 16
Hspb11 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPB11 35
  • 99.77 (n)
  • 99.31 (a)
HSPB11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspb11 35
  • 86.62 (n)
  • 85.92 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPB11 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPB11 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPB11 35
  • 66.67 (n)
  • 65.22 (a)
lizard
(Anolis carolinensis)
Reptilia HSPB11 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb11 35
  • 61.48 (n)
  • 57.78 (a)
Str.541 35
zebrafish
(Danio rerio)
Actinopterygii zgc:158640 35
  • 58.08 (n)
  • 50.76 (a)
HSPB11 36
  • 51 (a)
OneToOne
Species with no ortholog for HSPB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB11 Gene

ENSEMBL:
Gene Tree for HSPB11 (if available)
TreeFam:
Gene Tree for HSPB11 (if available)

Paralogs for HSPB11 Gene

No data available for Paralogs for HSPB11 Gene

Variants for HSPB11 Gene

Sequence variations from dbSNP and Humsavar for HSPB11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs742389 -- 53,927,119(-) GCTTT(G/T)AGCTC intron-variant
rs2206342 -- 53,928,435(+) CAAGG(G/T)CTGTA reference, missense
rs3830768 -- 53,923,844(+) ATAGG(-/T)TTAAA intron-variant
rs7542738 -- 53,940,840(+) aagta(C/G)ctgag intron-variant
rs10047036 -- 53,923,527(+) ATCTC(A/G)CTTGT intron-variant

Variation tolerance for HSPB11 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HSPB11 Gene

Disorders for HSPB11 Gene

Relevant External Links for HSPB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPB11

No disorders were found for HSPB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPB11 Gene

Publications for HSPB11 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. Characterization of mouse IFT complex B. (PMID: 19253336) Follit J.A. … Pazour G.J. (Cell Motil. Cytoskeleton 2009) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for HSPB11 Gene

Sources for HSPB11 Gene

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