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Aliases for HSPB11 Gene

Aliases for HSPB11 Gene

  • Heat Shock Protein Family B (Small) Member 11 2 3 5
  • Heat Shock Protein Family B (Small), Member 11 2 3
  • Heat Shock Protein Beta-11 3 4
  • Placental Protein 25 3 4
  • C1orf41 3 4
  • IFT25 3 4
  • PP25 3 4
  • Intraflagellar Transport 25 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 25 Homolog 3
  • Intraflagellar Transport 25 Homolog 3
  • Chromosome 1 Open Reading Frame 41 2
  • HSPCO34 3
  • Hspb11 4

External Ids for HSPB11 Gene

Previous HGNC Symbols for HSPB11 Gene

  • C1orf41

Previous GeneCards Identifiers for HSPB11 Gene

  • GC01M054159
  • GC01M054387
  • GC01M052502

Summaries for HSPB11 Gene

GeneCards Summary for HSPB11 Gene

HSPB11 (Heat Shock Protein Family B (Small) Member 11) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport.

UniProtKB/Swiss-Prot for HSPB11 Gene

  • Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).

Additional gene information for HSPB11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPB11 Gene

Genomics for HSPB11 Gene

GeneHancer (GH) Regulatory Elements for HSPB11 Gene

Promoters and enhancers for HSPB11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I053942 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 573.5 +1.0 991 5.4 HDGF SMAD1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR2B ZNF766 HSPB11 LRRC42 MAGOH SSBP3-AS1 NDC1 CYB5RL PARS2 TTC4 TCEANC2 GC01P053939
GH01I054051 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.8 -106.9 -106851 3.7 DMAP1 YY1 SLC30A9 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SSRP1 TCEANC2 MIR4781 TMEM59 MAGOH NDC1 SSBP3-AS1 HSPB11 LRRC42 PARS2 CYB5RL
GH01I053835 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.2 +109.2 109171 4.1 MLX DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D NDC1 MAGOH SSBP3-AS1 HSPB11 LRRC42 ECHDC2 ENSG00000256407 CYB5RL C1orf123 ENSG00000279049
GH01I054882 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 -939.9 -939891 7.8 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000233203 DHCR24 ENSG00000242396 SSBP3-AS1 HSPB11 ENSG00000279049 TMEM61 TTC22 PARS2 LRRC42
GH01I053014 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.4 +931.1 931101 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 SCP2 HSPB11 PRPF38A GC01P053008 GC01P053051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPB11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPB11 gene promoter:

Genomic Locations for HSPB11 Gene

Genomic Locations for HSPB11 Gene
chr1:53,916,574-53,946,303
(GRCh38/hg38)
Size:
29,730 bases
Orientation:
Minus strand
chr1:54,382,247-54,411,602
(GRCh37/hg19)

Genomic View for HSPB11 Gene

Genes around HSPB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPB11 Gene

Proteins for HSPB11 Gene

  • Protein details for HSPB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y547-IFT25_HUMAN
    Recommended name:
    Intraflagellar transport protein 25 homolog
    Protein Accession:
    Q9Y547
    Secondary Accessions:
    • A6NG57
    • D3DQ45
    • Q9Y684

    Protein attributes for HSPB11 Gene

    Size:
    144 amino acids
    Molecular mass:
    16297 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27; the interaction is direct. Interacts with IFT88 (By similarity).
    SequenceCaution:
    • Sequence=AAD43011.1; Type=Frameshift; Positions=77; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSPB11 Gene

neXtProt entry for HSPB11 Gene

Post-translational modifications for HSPB11 Gene

No Post-translational modifications

Other Protein References for HSPB11 Gene

No data available for DME Specific Peptides for HSPB11 Gene

Domains & Families for HSPB11 Gene

Gene Families for HSPB11 Gene

Protein Domains for HSPB11 Gene

Suggested Antigen Peptide Sequences for HSPB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y547

UniProtKB/Swiss-Prot:

IFT25_HUMAN :
  • Belongs to the IFT25 family.
Family:
  • Belongs to the IFT25 family.
genes like me logo Genes that share domains with HSPB11: view

Function for HSPB11 Gene

Molecular function for HSPB11 Gene

UniProtKB/Swiss-Prot Function:
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).

Phenotypes From GWAS Catalog for HSPB11 Gene

Gene Ontology (GO) - Molecular Function for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HSPB11: view
genes like me logo Genes that share phenotypes with HSPB11: view

Animal Models for HSPB11 Gene

MGI Knock Outs for HSPB11:

Animal Model Products

CRISPR Products

miRNA for HSPB11 Gene

miRTarBase miRNAs that target HSPB11

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPB11 Gene

Localization for HSPB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPB11 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPB11 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IEA --
GO:0005929 cilium IEA,TAS --
GO:0030992 intraciliary transport particle B ISS,IEA --
GO:0042995 cell projection IEA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with HSPB11: view

Pathways & Interactions for HSPB11 Gene

genes like me logo Genes that share pathways with HSPB11: view

Pathways by source for HSPB11 Gene

Gene Ontology (GO) - Biological Process for HSPB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006810 transport IEA --
GO:0007224 smoothened signaling pathway IEA --
GO:0007507 heart development IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with HSPB11: view

No data available for SIGNOR curated interactions for HSPB11 Gene

Drugs & Compounds for HSPB11 Gene

No Compound Related Data Available

Transcripts for HSPB11 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPB11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c
SP1: - - - - - - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - - - - -
SP7:

Relevant External Links for HSPB11 Gene

GeneLoc Exon Structure for
HSPB11
ECgene alternative splicing isoforms for
HSPB11

Expression for HSPB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPB11 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPB11 Gene



Protein tissue co-expression partners for HSPB11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPB11 Gene:

HSPB11

SOURCE GeneReport for Unigene cluster for HSPB11 Gene:

Hs.525462

mRNA Expression by UniProt/SwissProt for HSPB11 Gene:

Q9Y547-IFT25_HUMAN
Tissue specificity: Detected in placenta.

Evidence on tissue expression from TISSUES for HSPB11 Gene

  • Bone marrow(4.2)
  • Lung(4.2)
  • Blood(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with HSPB11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPB11 Gene

Orthologs for HSPB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPB11 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia HSPB11 33 34
  • 91.08 (n)
cow
(Bos Taurus)
Mammalia HSPB11 33
  • 90.44 (n)
C3H1ORF41 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspb11 33 16 34
  • 86.85 (n)
rat
(Rattus norvegicus)
Mammalia Hspb11 33
  • 86.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSPB11 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPB11 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPB11 33
  • 66.67 (n)
lizard
(Anolis carolinensis)
Reptilia HSPB11 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspb11 33
  • 61.48 (n)
Str.541 33
zebrafish
(Danio rerio)
Actinopterygii zgc:158640 33
  • 58.08 (n)
HSPB11 34
  • 51 (a)
OneToOne
Species where no ortholog for HSPB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPB11 Gene

ENSEMBL:
Gene Tree for HSPB11 (if available)
TreeFam:
Gene Tree for HSPB11 (if available)

Paralogs for HSPB11 Gene

Pseudogenes.org Pseudogenes for HSPB11 Gene

genes like me logo Genes that share paralogs with HSPB11: view

No data available for Paralogs for HSPB11 Gene

Variants for HSPB11 Gene

Sequence variations from dbSNP and Humsavar for HSPB11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000288372 -- 53,928,705(-) T/G intron_variant
rs1000308348 -- 53,922,256(-) T/C intron_variant
rs1000672830 -- 53,941,078(-) T/C/G intron_variant
rs1000856803 -- 53,945,920(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000860244 -- 53,937,015(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPB11 Gene

Variant ID Type Subtype PubMed ID
nsv1011262 CNV gain 25217958

Variation tolerance for HSPB11 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.41; 96.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPB11 Gene

Human Gene Mutation Database (HGMD)
HSPB11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPB11 Gene

Disorders for HSPB11 Gene

Additional Disease Information for HSPB11

No disorders were found for HSPB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPB11 Gene

Publications for HSPB11 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Characterization of mouse IFT complex B. (PMID: 19253336) Follit JA … Pazour GJ (Cell motility and the cytoskeleton 2009) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26). (PMID: 2018407) Bohn H … Winckler W (Archives of gynecology and obstetrics 1991) 3 4 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for HSPB11 Gene

Sources for HSPB11 Gene

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