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HSPB1 Gene

protein-coding GIFtS: 72

GC07P075769

heat shock 27kDa protein 1
(Previous name: heat shock 27kD protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CMT2F ^², ⁵
DKFZp586P1322 ^²
HMN2B ^², ⁵
HS.76067 ^²
HSP27 ^¹, ², ³, ⁵
HSP28 ^¹, ², ³
Hsp25 ^¹, ²
HspB1 ^³
OTTHUMP00000024846 ^²
SRP27 ^², ³

Descriptions
28 kDa heat shock protein ^³
Estrogen-regulated 24 kDa protein ^², ³
HSP 27 ^³
Heat shock 27 kDa protein ^³
Stress-responsive protein 27 ^², ³
heat shock 27kD protein 1 ^¹, ²
heat shock 27kDa protein 1 ^²
heat shock protein beta-1 ^²

External Ids
HGNC: 5246¹
Entrez Gene: 3315²
UniProtKB: P04792³
Ensembl: ENSG00000106211⁷

Search outside databases for aliases for HSPB1 gene

Previous GC identifers: GC07P074467 GC07P075530 GC07P075544 GC07P075576

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HSPB1:

The protein encoded by this gene is induced by environmental stress and developmental changes. The

encoded protein is involved in stress resistance and actin organization and translocates from the

cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of

Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN).

[provided by RefSeq]

UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792

Function: Involved in stress resistance and actin organization

Gene Wiki entry for HSPB1 (Hsp27)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HSPB1 gene

Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q

HSPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P075769: (about GC identifiers)

Start:	75,769,859 bp from pter
End:	75,771,548 bp from pter
Size:	1,690 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 75,264,987-75,266,676

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792 (See protein sequence)

Recommended Name: Heat shock protein beta-1

Size: 205 amino acids; 22783 Da

Subunit: Interacts with TGFB1I1 (By similarity). Associates with alpha- and beta-tubulin,

microtubules and CRYAB. Interacts with HSPB8 and HSPBAP1

Subcellular location: Cytoplasm. Nucleus. Spindle. Note=Cytoplasmic in interphase cells.

Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock

Sequence caution: Sequence=AAA62175.1; Type=Frameshift; Positions=194; Sequence=AAB20722.1;

Type=Frameshift; Positions=194; Sequence=CAA34498.1; Type=Frameshift; Positions=194;

Secondary accessions: Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36

Post-translational modifications:

Phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001531.1

ENSEMBL proteins:

ENSP00000248553

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant HSPB1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for HSPB1 (HSP27)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hsp27)
	Human Recombinant Proteins from Abnova (HSPB1)

OriGene Purified Recombinant Human Protein: HSPB1

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	16130169
GO:0005819	spindle	IEA	--
GO:0005856	cytoskeleton	TAS	16130169
GO:0009986	cell surface	IDA	12493773

About this table

Antibodies for HSPB1:

	Invitrogen Antibodies for HSPB1
	Millipore Mono- and Polyclonal Antibodies for the study of HSPB1
	Sigma-Aldrich Antibody Arrays and Antibodies for HSPB1
	R&D Systems Antibodies for HSPB1 (HSP27)
	Cell Signaling Technology (CST) Antibodies for HSPB1 (HSP27)
	Antibodies from Abcam (Hsp27), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for HSPB1

Assays for HSPB1:

	Invitrogen Assays for HSPB1
	Millipore Kits and Assays for the Analysis of HSPB1
	R&D Systems ELISAs for HSPB1 (HSP27) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for HSPB1 (HSP27)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04792

ProtoNet protein and cluster: P04792

1 Blocks protein family: IPB002068 Heat shock protein Hsp20

UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792

Similarity: Belongs to the small heat shock protein (HSP20) family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSPB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HSPB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001540

Applied Biosystems Silencer® siRNAs for HSPB1

Sigma-Aldrich siRNA for HSPB1

Sigma-Aldrich shRNA Panels and shRNA for HSPB1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HSPB1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001540
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001540
untagged cDNA clone in CMV expression vector: NM_001540

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001540

UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792

Function: Involved in stress resistance and actin organization

Induction: Expressed in response to environmental stresses such as heat shock, or estrogen

stimulation in MCF-7 cells

Genatlas biochemistry entry for HSPB1:

heat shock protein 1,estrogen receptor related

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Hspb1):

normal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042802	identical protein binding	IPI	11003656

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for HSPB1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

p38 MAPK Signaling
Death Receptor Signaling
IL-6 Signaling
Cardiac Hypertrophy Signaling
ERK/MAPK Signaling

GeneDecks HSPB1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HSPB1

5/50 Interacting proteins for HSPB1 (ENSP00000248553³ P04792^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HSPB8	Q9UJY1¹	STRING (score=.961) EBI-352682, EBI-739074
CRYAB	P02511²	STRING (score=.871) MINT-17168
TP53	P04637²	STRING (score=.726) MINT-4302652
DAXX	Q9UER7¹	EBI-352682, EBI-77321
HSPB1	P04792¹	EBI-352682, EBI-352682

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006446	regulation of translational initiation	TAS	10859165
GO:0006916	anti-apoptosis	TAS	16130169
GO:0006928	cell motion	TAS	16130169
GO:0006986	response to unfolded protein	TAS	10859165
GO:0009408	response to heat	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HSPB1
10/52 Novoseek chemical compound relationships for HSPB1 gene (see all 52 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
17-(allylamino)-17-demethoxygeldanamycin	53.82	6	19383903 (3), 17173546 (2)
sp 600125	46.31	8	12943527 (3), 15062846 (2), 18407296 (1), 16876988 (1) (see all 5)
pd 98,059	43.89	16	11909638 (3), 11483406 (2), 10572244 (2), 11034403 (2) (see all 10)
okadaic acid	38.56	12	8690728 (2), 8380591 (1), 18241680 (1), 7510704 (1) (see all 9)
12-o-tetradecanoylphorbol 13-acetate	35.04	24	10572244 (3), 17673262 (3), 10839933 (2), 9332492 (1) (see all 8)
dbc-amp	32.70	9	11701442 (2), 7541446 (1), 12694807 (1), 15848222 (1) (see all 7)
cdcl2	32.53	7	11525238 (2), 11497330 (2), 10379001 (1)
manganese superoxide	30.37	4	12385642 (2), 17593366 (1), 17884789 (1)
progesterone	30.08	28	8142264 (4), 1851492 (2), 1562530 (2), 9219918 (2) (see all 16)
ecdysone	29.33	2	1846802 (1), 12175493 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HSPB1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HSPB1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001540

Sigma-Aldrich siRNA for HSPB1

Sigma-Aldrich shRNA Panels and shRNA for HSPB1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001540

REFSEQ mRNAs for HSPB1 gene:

NM_001540.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001540

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001540
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001540
                                 untagged cDNA clone in CMV expression vector: NM_001540

Additional cDNA sequence:

AB020027.1 AF086135.1 AK296890.1 AK311446.1 AK311894.1 AL050380.1 BC000510.2 BC012292.1

BC012768.2 BC014920.1 BC073768.1 BT019888.1 CR407614.1 CR536489.1 CR591310.1 CR602417.1

CR603713.1 CR605148.1 CR606208.1 CR607252.1 CR608836.1 CR609210.1 CR611496.1 S74571.1

U90906.1 X16477.1 X54079.1

24/41 DOTS entries (see all 41 ):

DT.91648006 DT.97869739 DT.101986742 DT.95186317 DT.100738944 DT.100886895 DT.100886894 DT.95365380

DT.100886884 DT.80100707 DT.91870325 DT.100886876 DT.95365364 DT.100886881 DT.100886879 DT.86996824

DT.100886873 DT.100886891 DT.121077547 DT.87009731 DT.95365341 DT.100660034 DT.100886874 DT.100886882

24/2126 AceView cDNA sequences (see all 2126 ):

BI819052 BM827986 BQ651753 BM887777 BM919872 BM912150 CR609210 BU557899

CD675553 BU728236 BE858184 AI149133 BM909888 BU189491 BM826205 BG752568

BM833965 BM672677 AU134929 AA302272 BM787855 AL541694 BM747288 CD674863

highest scoring ESTs for HSPB1:

AA022819 AA033557 AA040623 AA042877 AA044229 AA044762 AA045029 AA045039 AA045787 AA052937

Unigene Cluster for HSPB1:

Heat shock 27kDa protein 1

Hs.520973 [show with all ESTs]

Unigene Representative Sequence: BM454532

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for HSPB1

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c
SP1:			-		-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for HSPB1

1 Ensembl transcript including schematic representation:

ENST00000248553

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HSPB1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HSPB1

¹ / ² / ³

4 probe-sets matching HSPB1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36785_at²^{, 3}	U95-A	3	1.00	0.51	0.99	0.92	Z23090	0.60	0.75	0.68	1
63673_at²^{, 3}	U95-C	2	0.56	0.61	1.00	1.08	AI635057	0.60	1.00	0.82	1
201841_s_at²^{, 3}	U133-A	3	1.00	0.58	--	--	NM_001540	0.60	1.00	0.82	1
201841_s_at²	U133Plus2	3	1.00	0.58	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCAAGCTAG

SOURCE GeneReport for Unigene cluster: Hs.520973
Expression variation in blood from EXPOLDB for HSPB1
UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792
Tissue specificity: Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine,
small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose
tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest
levels are found in the heart and in tissues composed of striated and smooth muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSPB1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HSPB1¹	--	heat shock 27kDa protein 1	87.75(n) 88.24(a)	403979 NM_001003295.1 NP_001003295.1
chimpanzee (Pan troglodytes)	HSPB1¹	--	heat shock 27kDa protein 1	98.59(n) 98.41(a)	463488 XM_519162.2 XP_519162.2
cow (Bos taurus)	HSPB1¹	--	heat shock 27kDa protein 1	88.1(n) 89.8(a)	516099 NM_001025569.1 NP_001020740.1
rat (Rattus norvegicus)	Hspb1¹	--	heat shock protein 1	81.57(n) 83.42(a)	24471 NM_031970.1 NP_114176.1
mouse (Mus musculus)	Hspb1^{1, 5}	5 (76.00 cM)⁵	heat shock protein 1^{1, 5}	83.58(n)¹ 84.88(a)¹	15507¹ NM_013560.1¹ NP_038588.1¹ AA013886⁵ AF047377⁵ (see all 21)

About this table Species with no ortholog for HSPB1

ENSEMBL Gene Tree for HSPB1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HSPB1 gene

CRYAA² CRYAB² HSPB6²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/68 NCBI SNPs in HSPB1 are shown (see all 68 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2868371^1,2	A,C,F,H	75768695(-)	`tctttG/Cttcca`	1	--	ng5¹		8	EU EA WA	836
--	rs2009836^1,2	A,C,F,H	75769096(-)	`TACAAA/GTACAA`	1	--	ng5¹ tfbs³		4	EU EA WA	368
	rs6963310^1,2	C,F,H	75769612(+)	`TCTGTC/TCTCCT`	1	--	ng5¹		9	EU EA WA NS	602
	rs2070804^1,2	C,F,H	75771648(+)	`CCATGT/GGGGTA`	1	--	ng3¹		10	EA EU WA NS	1896
	rs2903813^1,2	C,F,H	75768725(-)	`gacttT/Cgaagc`	1	--	ng5¹		8	EU EA WA	840
	rs2868370^1,2	F,H	75768736(-)	`ttaggC/Tgtgtg`	1	--	ng5¹		4	EU EA WA	418
	rs10252296^1,2	F,H	75768610(+)	`gTTACC/TATCat`	1	--	ng5¹		4	EU EA WA	420
	rs2903814^1,2	F,H	75768658(-)	`ttagaT/Gtcttt`	1	--	ng5¹		4	EU EA WA	420
--	rs34484713^1,2	F	75771920(+)	`AGTTG-/TGAAGGG`	1	--	ng3¹		5	NS	182
	rs34428939^1,2	F	75771702(+)	`AGACAG/CAGGTC`	1	--	ng3¹		5	NS	182

About this table

HapMap Linkage Disequilibrium images for HSPB1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602195 disorders: 608634 606595

UniProtKB/Swiss-Prot: HSPB1_HUMAN, P04792

Defects in HSPB1 are the cause of Charcot-Marie-Tooth disease type 2F (CMT2F)

[MIM:606595]. CMT2F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder

of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on

the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating

neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2

group are characterized by signs of axonal regeneration in the absence of obvious myelin

alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle

weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. CMT2F onset is

between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs

(peroneal distribution). Upper limb involvement occurs later. CMT2F inheritance is autosomal

dominant

Defects in HSPB1 are a cause of distal hereditary motor neuronopathy type 2B (HMN2B)

[MIM:608634]. Distal hereditary motor neuronopathies constitute a heterogeneous group of

neuromuscular disorders caused by selective impairment of motor neurons in the anterior horn of

the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture

consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory

loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and

peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal

muscles of the lower limbs and/or to the distal upper limbs

10/95 Novoseek disease relationships for HSPB1 gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	91.56	613	16840785 (4), 1730670 (4), 12423255 (4), 2037626 (4) (see all 99)
alexanders disease	57.44	5	8256860 (2), 8393618 (2), 7541446 (1)
charcot-marie-tooth disease	56.08	5	17881652 (2), 18587268 (1), 16215937 (1), 16155736 (1)
tumors	45.47	212	9179613 (6), 12820652 (6), 16234246 (5), 8590455 (5) (see all 92)
breast cancer	45.27	102	15833836 (5), 8402609 (4), 19080259 (4), 9307847 (3) (see all 46)
ehrlich ascites tumor	37.04	4	1930221 (2), 8647651 (1), 9665826 (1)
carcinoma squamous cell	36.67	35	11836604 (3), 9210326 (2), 14702179 (2), 16619543 (2) (see all 22)
cancer	32.54	34	19214136 (3), 9815962 (2), 17106261 (2), 11156417 (2) (see all 21)
metastasis	30.50	31	16696328 (2), 9568646 (2), 11836604 (2), 19166925 (1) (see all 16)
breast carcinoma	30.17	13	1988702 (4), 14715258 (2), 9568111 (1), 7579511 (1) (see all 7)

About this table

GeneTests: HSPB1

Charcot-Marie-Tooth Neuropathy Type 2

Human Gene Mutation Database: HSPB1
Genetic Association Database: HSPB1
Human Genome Epidemiology Navigator: HSPB1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/733 PubMed articles for HSPB1 gene (see all 733 ):

cDNA sequence of a human heat shock protein HSP27. (PubMed id 2243808)^{2, 3, 4} Carper S.W.... Storm F.K. (1990)
Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells. (PubMed id 10777697)^{1, 3, 4} Hino M.... Hosoya H. (2000)
[Mutation analysis of small heat shock protein 27 gene in Chinese patients with Charcot-Marie-Tooth disease] (PubMed id 16215937)^{1, 3, 6} Liu X.M....Jiang H. (2005)
Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. (PubMed id 1730670)^{1, 3, 4} Landry J....Anderson C.W. (1992)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation. (PubMed id 15976317)^{3, 4} De Souza A.I....Rose M.L. (2005)
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)^{3, 4} Gevaert K.... Vandekerckhove J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3315	HGNC: 5246	AceView: HSPB1	Ensembl:ENSG00000106211	euGenes: HUgn3315
ECgene: HSPB1	H-InvDB: HSPB1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HSPB1	Genetics and Cytogenetics in Oncology and Haematology
Inherited peripheral neuropathies mutation db	http://www.molgen.ua.ac.be/CMTMutations/
GeneReviews	http://www.genetests.org/query?gene=HSPB1
NIEHS SNPs	http://egp.gs.washington.edu/data/hspb1/

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for HSPB1:

TaqMan ® Gene Expression Assays

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Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HSPB1-related products

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Antibodies for HSPB1

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Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HSPB1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for HSPB1

Summaries
for HSPB1

Genomic Location
for HSPB1

Proteins
for HSPB1

Protein Domains/
Families
for HSPB1

Gene Function
for HSPB1

Pathways & Interactions
for HSPB1

Drugs & Compounds
for HSPB1

Transcripts
for HSPB1

Expression
for HSPB1

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for HSPB1

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for HSPB1

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for HSPB1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HSPB1 (Gene Symbol)
CMT2F
DKFZp586P1322
HMN2B
HS.76067
HSP27
HSP28
Hs.76067
Hsp25
HspB1
OTTHUMP00000024846
SRP27
28 kDa heat shock protein
Estrogen-regulated 24 kDa protein
HSP 27
Heat shock 27 kDa protein
Stress-responsive protein 27
heat shock 27kD protein 1
heat shock 27kDa protein 1
heat shock protein beta-1

HSPB1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor HSPB1

Summariesfor HSPB1

Genomic Locationfor HSPB1

Proteinsfor HSPB1

Protein Domains/Familiesfor HSPB1

Gene Functionfor HSPB1

Pathways & Interactionsfor HSPB1

Drugs & Compoundsfor HSPB1

Transcriptsfor HSPB1

Expression for HSPB1

Orthologsfor HSPB1

Paralogsfor HSPB1

SNPs/Variantsfor HSPB1

Disorders & Mutationsfor HSPB1

Medical Newsfor HSPB1

Publicationsfor HSPB1

Search for HSPB1

Genome Databases showing HSPB1

Other Databases showing HSPB1

Specialized Databases showing HSPB1

Licensable Technologiesfor HSPB1

Servicesfor HSPB1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HSPB1

Summaries
for HSPB1

Genomic Location
for HSPB1

Proteins
for HSPB1

Protein Domains/
Families
for HSPB1

Gene Function
for HSPB1

Pathways & Interactions
for HSPB1

Drugs & Compounds
for HSPB1

Transcripts
for HSPB1

Expression
for HSPB1

Orthologs
for HSPB1

Paralogs
for HSPB1

SNPs/Variants
for HSPB1

Disorders & Mutations
for HSPB1

Medical News
for HSPB1

Publications
for HSPB1

Licensable Technologies
for HSPB1

Services
for HSPB1