Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPA9 Gene

protein-coding GIFtS: 64
GCID: GC05M137890

heat shock 70kDa protein 9 (mortalin)

(Previous name: heat shock 70kDa protein 9B (mortalin-2) )
(Previous symbol: HSPA9B)

Explore 41 diseases affiliated with
HSPA9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 9 (Mortalin)¹ ²		Mthsp75¹
GRP75¹ ² ³ ⁵		CSA²
HSPA9B¹ ² ³ ⁵		MTHSP75²
PBP74¹ ² ³		Heat Shock 70kD Protein 9B²
Peptide-Binding Protein 74² ³		Mortalin, Perinuclear²
75 KDa Glucose-Regulated Protein² ³		Mortalin-2¹
GRP-75² ³		P66-Mortalin¹
MOT² ³		Stress-70 Protein, Mitochondrial²
MOT2² ⁵		Mortalin³
Heat Shock 70kDa Protein 9B (Mortalin-2)¹		Heat Shock 70 KDa Protein 9³
Mot-2¹

External Ids:	HGNC: 5244¹	Entrez Gene: 3313²	Ensembl: ENSG00000113013⁷	OMIM: 600548⁵	UniProtKB: P38646³

Export aliases for HSPA9 gene to outside databases

Previous GC identifers: GC05M137920 GC05M137923 GC05M133080

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA9:

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the

mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is

a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the

mitochondria. A pseudogene of this gene is found on chromosome 2.(provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

Gene Wiki entry for HSPA9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPA9 gene promoter:
AML1a Bach2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 C/EBPalpha Evi-1 POU2F1 POU2F1a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): HSPA9 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPA9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.1

HSPA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA9 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M137890: view genomic region (about GC identifiers)

Start:	137,890,571 bp from pter	End:	137,911,318 bp from pter
Size:	20,748 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646 (See protein sequence)

Recommended Name: Stress-70 protein, mitochondrial precursor

Size: 679 amino acids; 73680 Da

Subunit: Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and

CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2

Subcellular location: Mitochondrion. Nucleus, nucleolus

1 PDB 3D structure from and Proteopedia for HSPA9:

3N8E (3D)

Secondary accessions: B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56

Explore the universe of human proteins at neXtProt for HSPA9: NX_P38646

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P38646

HSPA9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004125.3

ENSEMBL proteins:

ENSP00000297185 ENSP00000421892 ENSP00000429475 ENSP00000421311 ENSP00000423759

ENSP00000420944 ENSP00000425598 ENSP00000423098

Reactome Protein details: P38646
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for HSPA9
	OriGene Purified Protein: HSPA9 OriGene Protein Over-expression Lysate: HSPA9 OriGene Custom Protein Services for HSPA9
	GenScript Custom Purified and Recombinant Proteins Services for HSPA9
	Novus Biologicals HSPA9 Proteins Novus Biologicals HSPA9 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HSPA9
	Uscn Proteins for HSPA9

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IEA	--
GO:0005737	cytoplasm	TAS	7684501
GO:0005739	mitochondrion	TAS	16130169
GO:0009986	cell surface	IDA	12493773
GO:0042645	mitochondrial nucleoid	IDA	18063578

HSPA9 for ontologies About GeneDecksing

HSPA9 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HSPA9 (GRP75/HSPA9B)
	Cell Signaling Technology (CST) Antibodies for HSPA9 (HSPA9B)
	OriGene Antibodies (see all 5): HSPA9 OriGene Custom Antibody Services for HSPA9
	GenScript Custom Superior Antibodies Services for HSPA9
	Novus Biologicals HSPA9 Antibodies
	Abcam antibodies for HSPA9
	Uscn Antibodies for HSPA9
	ThermoFisher Antibody for HSPA9

Assay Products for HSPA9:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSPA9
	Enzo Life Sciences assays for HSPA9
	Uscn ELISAs and CLIAs for HSPA9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA9 for domains About GeneDecksing

3 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR012725 Chaperone_DnaK

IPR013126 Hsp_70_fam

Graphical View of Domain Structure for InterPro Entry P38646

ProtoNet protein and cluster: P38646

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Similarity: Belongs to the heat shock protein 70 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646

Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

miRNA Products:		OriGene 3'-UTR Clone: HSPA9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA9
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA9 (see all 13):
		hsa-miR-217 hsa-miR-429 hsa-miR-767-3p hsa-miR-509-5p hsa-miR-708* hsa-miR-1301 hsa-miR-200c hsa-miR-873

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA9 (see all 7) OriGene shRNA RFP: HSPA9 OriGene siRNA: HSPA9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA9

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSPA9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPA9 (NM_004134)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSPA9
		Search LifeMap BioReagents cell lines for HSPA9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA9

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0019899	enzyme binding	IEA	--
GO:0051082	unfolded protein binding	TAS	16130169

HSPA9 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for HSPA9:

Decreased TP53 protein express	Decreased viability of wild-ty	Enable proliferation in B-Raf	Increased 8N DNA content
Synthetic lethal with Ras	Wnt reporter downregulated

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Proteolysis Putative ubiquitin pathway

Proteolysis Putative ubiquitin pathway

1.00

Proteolysis_Putative ubiquitin pathway

0.97

Mitochondrial Protein Import

Mitochondrial Protein Import

1.00

Tuberculosis

Tuberculosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSPA9

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

1 Cell Signaling Technology (CST) Pathway for HSPA9

Translational Control

5/6 GeneGo (Thomson Reuters) Pathways for HSPA9 (see all 6)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Regulation of degradation of deltaF508 CFTR in CF
	CFTR folding and maturation (norm and CF)
	Proteolysis Putative ubiquitin pathway

1 BioSystems Pathway for HSPA9

Parkin-Ubiquitin Proteasomal System pathway

2 Reactome Pathways for HSPA9

	Mitochondrial Protein Import
	Metabolism of proteins

2 Kegg Pathways (Kegg details for HSPA9):

	RNA degradation
	Tuberculosis

HSPA9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/657 Interacting proteins for HSPA9 (P38646^{1, 2, 3} ENSP00000297185⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 657)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--
GO:0006611	protein export from nucleus	IEA	--
GO:0006626	protein targeting to mitochondrion	TAS	--
GO:0043066	negative regulation of apoptotic process	TAS	16130169
GO:0044267	cellular protein metabolic process	TAS	--

HSPA9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPA9 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA9
7 Novoseek chemical compound relationships for HSPA9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glyceraldehyde 3-phosphate	15.9	2	16220529 (1), 9504817 (1)
ouabain	15	3	12433836 (2), 17172693 (1)
atp	13.4	4	16220529 (1), 12488463 (1), 15724436 (1), 10221157 (1)
glucose	0	11	15724436 (4), 19659607 (1), 12371145 (1), 11099777 (1) (see all 5)
calcium	0	1	12687615 (1)
tyrosine	0	6	11162655 (4)
phosphatidylinositol	0	1	17635236 (1)

Search CenterWatch for drugs/clinical trials and news about HSPA9 / GRP75

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPA9 gene:

NM_004134.6

Unigene Cluster for HSPA9:

Heat shock 70kDa protein 9 (mortalin)

Hs.184233 [show with all ESTs]

Unigene Representative Sequence: NM_004134

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297185(uc003ldf.3) ENST00000501917 ENST00000524109 ENST00000512328

ENST00000507097(uc011cyw.2) ENST00000523929 ENST00000508003 ENST00000504902

ENST00000507115 ENST00000505110 ENST00000504810 ENST00000506477 ENST00000507886

miRNA Products:		OriGene 3'-UTR Clone: HSPA9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA9
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA9 (see all 13):
		hsa-miR-217 hsa-miR-429 hsa-miR-767-3p hsa-miR-509-5p hsa-miR-708* hsa-miR-1301 hsa-miR-200c hsa-miR-873

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA9 (see all 7) OriGene shRNA RFP: HSPA9 OriGene siRNA: HSPA9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPA9 (NM_004134)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA9

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPA9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPA9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA9

Additional cDNA sequence:

AK222758.1 AK225488.1 AK293990.1 AK297795.1 AK297897.1 AK315177.1 BC000478.2 BC024034.2

BC030634.1 DQ185038.1 DQ480334.1 L11066.1 L15189.1

24/44 DOTS entries (see all 44):

DT.97836364 DT.95288765 DT.100887123 DT.120803652 DT.101977168 DT.92407569 DT.405321 DT.95288768

DT.99991700 DT.120803655 DT.97766955 DT.120803628 DT.92465522 DT.97836373 DT.99943195 DT.120803599

DT.120803672 DT.92325858 DT.100039307 DT.100887131 DT.100887134 DT.120803668 DT.120803688 DT.95128155

24/1018 AceView cDNA sequences (see all 1018):

BM694305 BU169253 BQ917877 AI613152 AI810378 CN483030 CD243936 BM788313

BM835717 BF512904 BG029950 BG674842 BI258960 BQ948358 BM827659 BM468247

AA356833 CA307074 BQ224193 BM453671 BE882329 BQ226239 BQ326134 CA426751

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^
SP1:									-		-		-												-						-
SP2:									-		-		-						-		-		-		-		-		-		-		-		-		-		-		-
SP3:									-		-		-												-
SP4:													-												-
SP5:									-		-		-

ExUns:	14	^	15	^	16a	·	16b	^	17	^	18	^	19
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HSPA9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPA9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTAGATG

About this image
See HSPA9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPA9

SOURCE GeneReport for Unigene cluster: Hs.184233

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA9:

Apoptosis 384HT in human mouse rat

Cellular Stress Responses in human mouse rat

Stem Cells in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPA9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSPA9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for HSPA9 gene from 11/44 species (see all 44) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hspa9^{1 , 5}	heat shock protein 9^{1, 5}	90.28(n)¹ 98.38(a)¹		18 (18.80 cM)⁵ 15526¹ NM_010481.2¹ NP_034611.2¹ 34937414⁵
chicken (Gallus gallus)	Aves	HSPA9¹	heat shock 70kDa protein 9 (mortalin)	80.21(n) 92.71(a)		416183 NM_001006147.1 NP_001006147.1
lizard (Anolis carolinensis)	Reptilia	HSPA9⁶	--	89(a)	1 ↔ 1	1(131018898-131036870)
African clawed frog (Xenopus laevis)	Amphibia	hspa9b-prov²	heat shock protein, 74 kDa, A	77.18(n)		BC045130.1
zebrafish (Danio rerio)	Actinopterygii	hspa9b²	heat shock protein 9B	80.26(n)		373085 BC044175.1
fruit fly (Drosophila melanogaster)	Insecta	Hsc70-5¹	Heat shock protein cognate 5	68.39(n) 78.02(a)		36583 NM_079017.2 NP_523741.2
worm (Caenorhabditis elegans)	Secernentea	hsp-6¹	Protein HSP-6	67.2(n) 77.3(a)		178873 NM_071890.3 NP_504291.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SSQ1(YLR369W)⁴ SSC1¹	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia less⁴ Ssc1p¹	62.51(n)¹ 65.62(a)¹		12(859552-861525)⁴ 853503¹ NP_012579.1¹ 851084⁴ NP_013473.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	MTHSC70-2¹	mitochondrial HSO70 2	63.67(n) 62.78(a)		830818 NM_120996.3 NP_196521.1
rice (Oryza sativa)	Liliopsida	AK103835.1²	--	76.62(n)		AK103835.1

ENSEMBL Gene Tree for HSPA9 (if available)
TreeFam Gene Tree for HSPA9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPA9 gene

14 SIMAP similar genes for HSPA9 using alignment to 9 protein entries: GRP75_HUMAN (see all proteins):

CIR1 HSP70-1 HSPA1L HSPA5 HSPA2 HSPA1A

HSPA8 HSPA6 HSPA7 HSPA1B HSPA14 C8orf44

HSPA13 HSPA4L

HSPA9 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for HSPA9
PGOHUM00000234911 PGOHUM00000241118 PGOHUM00000263161

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10063809^1,2	C,F,A,H,	--	137890101(+)	`ACCATA/GTAACA`	1	--	ds500¹		15		NS EA NA WA	1636
rs182014286^1,2		--	137890132(+)	`GTTCCA/CATTGA`	1	--	ds500¹		0	--	--	--	--
rs187614338^1,2		--	137890226(+)	`CTTCCA/CAAAAT`	1	--	ds500¹		0	--	--	--	--
rs189951276^1,2		--	137890360(+)	`ATTCTA/GAGCCC`	1	--	ds500¹		0	--	--	--	--
rs74490121^1,2		--	137890429(+)	`GAAATA/GTGCTG`	1	--	ds500¹		0	--	--	--	--
rs182179839^1,2		--	137890500(+)	`TCAGCA/CCATGA`	1	--	ds500¹		0	--	--	--	--
rs41296459^1,2	F	--	137890717(-)	`TGAAAGTTTTTAGATCT CTAACATGAAA/-ACCAA`	2	--	ut3¹		5		NS	186
rs41296461^1,2	F	--	137890735(-)	`AGTTTT/CTAGAT`	1	--	ut3¹		5		NS	178
rs185873014^1,2		--	137890757(+)	`GATCTA/GGAAAC`	1	--	ut3¹		0	--	--	--	--
rs367563^1,2	C,F,	--	137890758(+)	`ATCTAG/AAAACT`	1	--	ut3¹		5		NS	188

HapMap Linkage Disequilibrium report for HSPA9 (137890571 - 137911318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPA9: --
Human Gene Mutation Database (HGMD): HSPA9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPA9

DNA2.0 Custom Variant and Variant Library Synthesis for HSPA9

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA9 for disorders           About GeneDecksing

OMIM gene information: 600548    OMIM disorders: --

20/41 diseases for HSPA9 (see all 41):    About MalaCards

myotonic dystrophy type 2 myositis ossificans myotonic dystrophy atrial fibrillation

friedreich ataxia differentiating neuroblastoma chronic myeloid leukemia myositis

epithelial ovarian cancer myeloid leukemia parkinson's disease albinism

down syndrome ovarian cancer hermaphroditism lung adenocarcinoma

ataxia liver cancer colon carcinoma adenocarcinoma

6 Novoseek disease relationships for HSPA9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	58	24	16817317 (1), 16619038 (1), 19280369 (1), 12687615 (1) (see all 20)
cancer	31.6	30	14728808 (3), 17306926 (3), 17389721 (2), 17934217 (2) (see all 15)
parkinson disease	27.8	4	19657588 (2), 20152901 (1), 18219256 (1)
tumors	24.2	28	17306926 (3), 16425258 (3), 17934217 (3), 9417864 (2) (see all 10)
breast carcinoma	0	1	16425258 (1)
adenocarcinoma	0	2	15532096 (2)

Human Genome Epidemiology (HuGE) Navigator: HSPA9 (4 documents)

Export disorders for HSPA9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSPA9 gene, integrated from 9 sources (see all 217):
(articles sorted by number of sources associating them with HSPA9)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. (PubMed id 7684501)^{1, 2, 3} Domanico S.Z.... Pierce S.K. (1993)
MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)^{1, 2} Alkhaja A.K....Deckers M. (2012)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)^{1, 2} Ji H.... Simpson R.J. (1997)
Cloning and subcellular localization of human mitochondrial hsp70. (PubMed id 7829505)^{1, 2} Bhattacharyya T.... Morimoto R.I. (1995)
Human liver protein map: update 1993. (PubMed id 8313870)^{1, 2} Hughes G.J.... Hochstrasser D.F. (1993)
Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)^{1, 2} Hochstrasser D.F.... Hughes G.J. (1992)
Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. (PubMed id 17934217)^{1, 9} Yi X....Fan S.T. (2008)
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31. (PubMed id 11187902)^{1, 9} Xie H....Westbrook C.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3313	HGNC: 5244	AceView: HSPA9B	Ensembl:ENSG00000113013	euGenes: HUgn3313
ECgene: HSPA9	Kegg: 3313	H-InvDB: HSPA9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSPA9	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa9b/

Intellectual Property for HSPA9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HSPA9 gene:
Search GeneIP for patents involving HSPA9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for HSPA9 (GRP75/HSPA9B)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for HSPA9		OriGene shRNA RFP for HSPA9
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA9		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSPA9
	OriGene Protein Over-expression Lysate for HSPA9		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HSPA9		OriGene 3'-UTR Clone for HSPA9
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA9
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HSPA9		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HSPA9		OriGene Custom Protein Services for HSPA9
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPA9
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPA9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA9
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA9
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA9

	GenScript Custom Purified and Recombinant Proteins Services for HSPA9		GenScript cDNA clones with any tag delivered in your preferred vector for HSPA9
	GenScript Custom Assay Services for HSPA9		GenScript Custom Superior Antibodies Services for HSPA9
	GenScript Custom overexpressing Cell Line Services for HSPA9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for HSPA9 (HSPA9B)

	Regulatory tfbs in HSPA9 promoter
	Search Chromatin IP Primers for HSPA9
	RT² qPCR Primer Assay in human, mouse, rat HSPA9
	GNC Network for HSPA9
	SABiosciences PCR Arrays including human, mouse, rat HSPA9

Search Tocris compounds for HSPA9

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Proteins for HSPA9
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HSPA9 antibodies
	HSPA9 proteins
	HSPA9 lysates

	Antibodies for HSPA9
	See all of Abcam's Antibodies, Kits and Proteins for HSPA9
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for HSPA9

HSPA9 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HSPA9

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA9

	SwitchGear 3'UTR luciferase reporter plasmids for HSPA9
	SwitchGear Promoter luciferase reporter plasmids for HSPA9

ThermoFisher Antibody for HSPA9

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA9

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HSPA9 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HSPA9 Gene

heat shock 70kDa protein 9 (mortalin)

Aliases
for HSPA9 gene

Summaries
for HSPA9 gene

Genomic Views
for HSPA9 gene

Proteins
for HSPA9 gene

Protein Domains /
Families
for HSPA9 gene

Function
for HSPA9 gene

Pathways & Interactions
for HSPA9 gene

Drugs & Compounds
for HSPA9 gene

Transcripts
for HSPA9 gene

Expression
for HSPA9 gene

Orthologs
for HSPA9 gene

Paralogs
for HSPA9 gene

Genomic Variants
for HSPA9 gene

Disorders / Diseases
for HSPA9 gene

Publications
for HSPA9 gene

External Searches for HSPA9 gene

Genome Databases showing HSPA9 gene

Other Databases showing HSPA9 gene

Specialized Databases showing HSPA9 gene

Intellectual Property
for HSPA9 gene

Products
for HSPA9 gene

View Random Gene

HSPA9 (Gene Symbol)
Heat Shock 70kDa Protein 9 (Mortalin)
GRP75
HSPA9B
PBP74
Peptide-Binding Protein 74
75 KDa Glucose-Regulated Protein
GRP-75
MOT
MOT2
Heat Shock 70kDa Protein 9B (Mortalin-2)
Mot-2
Mthsp75
CSA
MTHSP75
Heat Shock 70kD Protein 9B
Mortalin, Perinuclear
Mortalin-2
P66-Mortalin
Stress-70 Protein, Mitochondrial
Mortalin
Heat Shock 70 KDa Protein 9

Advanced Search

Export list of displayed genes

HSPA9 Gene

heat shock 70kDa protein 9 (mortalin)

Aliasesfor HSPA9 gene

Summariesfor HSPA9 gene

Genomic Viewsfor HSPA9 gene

Proteinsfor HSPA9 gene

Protein Domains /Familiesfor HSPA9 gene

Functionfor HSPA9 gene

Pathways & Interactionsfor HSPA9 gene

Drugs & Compoundsfor HSPA9 gene

Transcriptsfor HSPA9 gene

Expression for HSPA9 gene

Orthologsfor HSPA9 gene

Paralogsfor HSPA9 gene

Genomic Variantsfor HSPA9 gene

Disorders / Diseasesfor HSPA9 gene

Publicationsfor HSPA9 gene

External Searches for HSPA9 gene

Genome Databases showing HSPA9 gene

Other Databases showing HSPA9 gene

Specialized Databases showing HSPA9 gene

Intellectual Propertyfor HSPA9 gene

Productsfor HSPA9 gene

View Random Gene

Aliases
for HSPA9 gene

Summaries
for HSPA9 gene

Genomic Views
for HSPA9 gene

Proteins
for HSPA9 gene

Protein Domains /
Families
for HSPA9 gene

Function
for HSPA9 gene

Pathways & Interactions
for HSPA9 gene

Drugs & Compounds
for HSPA9 gene

Transcripts
for HSPA9 gene

Expression
for HSPA9 gene

Orthologs
for HSPA9 gene

Paralogs
for HSPA9 gene

Genomic Variants
for HSPA9 gene

Disorders / Diseases
for HSPA9 gene

Publications
for HSPA9 gene

Intellectual Property
for HSPA9 gene

Products
for HSPA9 gene