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Aliases for HSPA9 Gene

Aliases for HSPA9 Gene

  • Heat Shock 70kDa Protein 9 (Mortalin) 2 3
  • 75 KDa Glucose-Regulated Protein 3 4
  • Peptide-Binding Protein 74 3 4
  • HSPA9B 3 4
  • GRP-75 3 4
  • GRP75 3 4
  • PBP74 3 4
  • MOT 3 4
  • Epididymis Secretory Sperm Binding Protein Li 124m 3
  • Heat Shock 70kDa Protein 9B (Mortalin-2) 2
  • Catecholamine-Regulated Protein 40 3
  • Heat Shock 70 KDa Protein 9 4
  • Heat Shock 70kD Protein 9B 3
  • Mortalin, Perinuclear 3
  • P66-Mortalin 3
  • HEL-S-124m 3
  • Mortalin-2 3
  • Mortalin 4
  • Mt-HSP70 4
  • MTHSP75 3
  • CRP40 3
  • MOT2 3
  • CSA 3

External Ids for HSPA9 Gene

Previous HGNC Symbols for HSPA9 Gene

  • HSPA9B

Previous GeneCards Identifiers for HSPA9 Gene

  • GC05M137920
  • GC05M137923
  • GC05M133080
  • GC05M137890

Summaries for HSPA9 Gene

Entrez Gene Summary for HSPA9 Gene

  • This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

GeneCards Summary for HSPA9 Gene

HSPA9 (Heat Shock 70kDa Protein 9 (Mortalin)) is a Protein Coding gene. Diseases associated with HSPA9 include parkinson disease, late-onset. Among its related pathways are Transport to the Golgi and subsequent modification and Cellular Senescence. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA9 Gene

  • Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Wiki entry for HSPA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA9 Gene

Genomics for HSPA9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA9 Gene

138,554,882 bp from pter
138,575,629 bp from pter
20,748 bases
Minus strand

Genomic View for HSPA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA9 Gene

Proteins for HSPA9 Gene

  • Protein details for HSPA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Stress-70 protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RCM1
    • P30036
    • P31932
    • Q1HB43
    • Q53H23
    • Q6GU03
    • Q9BWB7
    • Q9UC56

    Protein attributes for HSPA9 Gene

    679 amino acids
    Molecular mass:
    73680 Da
    Quaternary structure:
    • Interacts with FXN. Interacts with HSCB. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with DNLZ, the interaction is required to prevent self-aggregation. Interacts with TESPA1.

    Three dimensional structures from OCA and Proteopedia for HSPA9 Gene

neXtProt entry for HSPA9 Gene

Proteomics data for HSPA9 Gene at MOPED

Post-translational modifications for HSPA9 Gene

  • Ubiquitination at Lys 121 and Lys 646
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPA9 (HSPA9B)
  • Cloud-Clone Corp. Antibodies for HSPA9

No data available for DME Specific Peptides for HSPA9 Gene

Domains & Families for HSPA9 Gene

Gene Families for HSPA9 Gene

Protein Domains for HSPA9 Gene

Suggested Antigen Peptide Sequences for HSPA9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA9: view

Function for HSPA9 Gene

Molecular function for HSPA9 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Ontology (GO) - Molecular Function for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10411904
GO:0005524 ATP binding IEA --
GO:0017134 fibroblast growth factor binding IEA --
GO:0019899 enzyme binding --
GO:0031072 heat shock protein binding IEA --
genes like me logo Genes that share ontologies with HSPA9: view
genes like me logo Genes that share phenotypes with HSPA9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA9 Gene

Localization for HSPA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA9 Gene

Mitochondrion. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for HSPA9 Gene COMPARTMENTS Subcellular localization image for HSPA9 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 3
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm TAS 7684501
GO:0005739 mitochondrion TAS 16130169
GO:0005925 focal adhesion IDA 21423176
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with HSPA9: view

Pathways & Interactions for HSPA9 Gene

genes like me logo Genes that share pathways with HSPA9: view

PCR Array Products

SIGNOR curated interactions for HSPA9 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006611 protein export from nucleus IEA --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0009636 response to toxic substance IEA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
genes like me logo Genes that share ontologies with HSPA9: view

Drugs & Compounds for HSPA9 Gene

(4) Drugs for HSPA9 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ouabain Approved Pharma Na+/K+ ATPase inhibitor 0
ATP Pharma Activator 0
Calcium Nutra 0
tyrosine Nutra 547

(3) Additional Compounds for HSPA9 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
glyceraldehyde 3-phosphate
genes like me logo Genes that share compounds with HSPA9: view

Transcripts for HSPA9 Gene

Unigene Clusters for HSPA9 Gene

Heat shock 70kDa protein 9 (mortalin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - -
SP9: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: -
SP9: - - - - - -

Relevant External Links for HSPA9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA9 Gene

mRNA expression in normal human tissues for HSPA9 Gene

Protein differential expression in normal tissues from HIPED for HSPA9 Gene

This gene is overexpressed in Nasal epithelium (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA9 Gene

SOURCE GeneReport for Unigene cluster for HSPA9 Gene Hs.184233

genes like me logo Genes that share expression patterns with HSPA9: view

Protein tissue co-expression partners for HSPA9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA9 Gene

Orthologs for HSPA9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPA9 35
  • 92.69 (n)
  • 98.53 (a)
HSPA9 36
  • 99 (a)
(Canis familiaris)
Mammalia HSPA9 35
  • 92.73 (n)
  • 98.82 (a)
HSPA9 36
  • 99 (a)
(Mus musculus)
Mammalia Hspa9 35
  • 90.28 (n)
  • 98.38 (a)
Hspa9 16
Hspa9 36
  • 98 (a)
(Pan troglodytes)
Mammalia HSPA9 35
  • 99.85 (n)
  • 99.85 (a)
HSPA9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hspa9 35
  • 90.62 (n)
  • 98.38 (a)
(Monodelphis domestica)
Mammalia HSPA9 36
  • 96 (a)
(Gallus gallus)
Aves HSPA9 35
  • 81.25 (n)
  • 94.13 (a)
HSPA9 36
  • 92 (a)
(Anolis carolinensis)
Reptilia HSPA9 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa9 35
  • 78.16 (n)
  • 91.5 (a)
Str.4363 35
African clawed frog
(Xenopus laevis)
Amphibia hspa9b-prov 35
(Danio rerio)
Actinopterygii hspa9 35
  • 76.85 (n)
  • 89.51 (a)
hspa9b 35
hspa9 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.697 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010876 35
  • 67.88 (n)
  • 80.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-5 35
  • 68.23 (n)
  • 78.47 (a)
Hsc70-5 36
  • 74 (a)
(Caenorhabditis elegans)
Secernentea hsp-6 35
  • 66.77 (n)
  • 76.92 (a)
hsp-6 36
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR352C 35
  • 62.24 (n)
  • 68.12 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22309g 35
  • 63.6 (n)
  • 67.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSC1 35
  • 62.85 (n)
  • 66.4 (a)
SSA2 36
  • 50 (a)
SSQ1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons mtHsc70-1 35
  • 63.49 (n)
  • 64.13 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7686 35
(Oryza sativa)
Liliopsida Os09g0491772 35
  • 62.13 (n)
  • 63.54 (a)
(Zea mays)
Liliopsida Zm.700 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4684 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08693 35
  • 61.61 (n)
  • 68.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssc1 35
  • 60.24 (n)
  • 63.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for HSPA9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA9 Gene

Gene Tree for HSPA9 (if available)
Gene Tree for HSPA9 (if available)

Paralogs for HSPA9 Gene

Paralogs for HSPA9 Gene Pseudogenes for HSPA9 Gene

genes like me logo Genes that share paralogs with HSPA9: view

Variants for HSPA9 Gene

Sequence variations from dbSNP and Humsavar for HSPA9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_046482 -
VAR_046483 -
VAR_049622 -
VAR_049623 -

Variation tolerance for HSPA9 Gene

Residual Variation Intolerance Score: 13.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA9 Gene

Disorders for HSPA9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA9 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • kufor-rakeb syndrome
- elite association
Search HSPA9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA9 Gene

Publications for HSPA9 Gene

  1. Proteome profile in Myotonic Dystrophy type 2 myotubes reveals dysfunction in protein processing and mitochondrial pathways. (PMID: 20138216) Rusconi F. … Zippel R. (Neurobiol. Dis. 2010) 23 67
  2. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions. (PMID: 20153329) Iosefson O. … Azem A. (FEBS Lett. 2010) 23 67
  3. Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity. (PMID: 19739077) Pilzer D. … Fishelson Z. (Int. J. Cancer 2010) 23 67
  4. Kinetic and structural characterization of human mortalin. (PMID: 20152901) Luo W.I. … Cowan J.A. (Protein Expr. Purif. 2010) 23 67
  5. Differential effects of wild-type and A53T mutant isoform of alpha-synuclein on the mitochondrial proteome of differentiated SH-SY5Y cells. (PMID: 20334438) Pennington K. … Robinson P.A. (J. Proteome Res. 2010) 23 67

Products for HSPA9 Gene

Sources for HSPA9 Gene

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