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HSPA9 Gene

protein-coding   GIFtS: 66
GCID: GC05M137890

Heat Shock 70kDa Protein 9 (Mortalin)

(Previous name: heat shock 70kDa protein 9B (mortalin-2))
(Previous symbol: HSPA9B)
  See HSPA9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 9 (Mortalin)1 2     HEL-S-124m2
HSPA9B1 2 3 5     MTHSP752
GRP752 3 5     Epididymis Secretory Sperm Binding Protein Li 124m2
Peptide-Binding Protein 742 3     Heat Shock 70kD Protein 9B2
75 KDa Glucose-Regulated Protein2 3     Mortalin, Perinuclear2
GRP-752 3     mortalin-22
MOT2 3     p66-mortalin2
PBP742 3     Stress-70 Protein, Mitochondrial2
MOT22 5     Mortalin3
Heat Shock 70kDa Protein 9B (Mortalin-2)1     Heat Shock 70 KDa Protein 93
CSA2     mt-HSP703

External Ids:    HGNC: 52441   Entrez Gene: 33132   Ensembl: ENSG000001130137   OMIM: 6005485   UniProtKB: P386463   

Export aliases for HSPA9 gene to outside databases

Previous GC identifers: GC05M137920 GC05M137923 GC05M133080


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA9 Gene:
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to
the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This
protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and
maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.(provided by RefSeq, May
2010)

GeneCards Summary for HSPA9 Gene:
HSPA9 (heat shock 70kDa protein 9 (mortalin)) is a protein-coding gene. Diseases associated with HSPA9 include myotonic dystrophy type 2. GO annotations related to this gene include unfolded protein binding and enzyme binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646
Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

Gene Wiki entry for HSPA9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA9 gene promoter:
         AML1a   Bach2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   C/EBPalpha   Evi-1   POU2F1   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): HSPA9 promoter sequence
   Search Chromatin IP Primers for HSPA9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.1

HSPA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137890:  view genomic region     (about GC identifiers)

Start:
137,890,571 bp from pter      End:
137,911,318 bp from pter
Size:
20,748 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646 (See protein sequence)
Recommended Name: Stress-70 protein, mitochondrial precursor  
Size: 679 amino acids; 73680 Da
Subunit: Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9
and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Interacts with DNLZ,
the interaction is required to prevent self-aggregation
1 PDB 3D structure from and Proteopedia for HSPA9:
3N8E (3D)    
Secondary accessions: B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56

Explore the universe of human proteins at neXtProt for HSPA9: NX_P38646

Explore proteomics data for HSPA9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys121, Lys368, Lys646
  • Modification sites at PhosphoSitePlus

  • See HSPA9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004125.3  
    ENSEMBL proteins: 
     ENSP00000297185   ENSP00000421892   ENSP00000429475   ENSP00000421311   ENSP00000423759  
     ENSP00000420944   ENSP00000425598   ENSP00000423098  
    Reactome Protein details: P38646

    HSPA9 Human Recombinant Protein Products:

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    Novus Biologicals HSPA9 Proteins
    Novus Biologicals HSPA9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPA9
    Cloud-Clone Corp. Proteins for HSPA9

     
    Search eBioscience for Proteins for HSPA9 

     
    antibodies-online proteins for HSPA9 (19 products) 

     
    antibodies-online peptides for HSPA9

    HSPA9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for HSPA9 (99 products) 

    HSPA9 Assay Products:

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    Cloud-Clone Corp. ELISAs for HSPA9
    Cloud-Clone Corp. CLIAs for HSPA9
    Search eBioscience for ELISAs for HSPA9 
    antibodies-online kits for HSPA9 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    3 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR012725 Chaperone_DnaK
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P38646

    ProtoNet protein and cluster: P38646

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: GRP75_HUMAN, P38646
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP75_HUMAN, P38646
    Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10411904
    GO:0005524ATP binding IEA--
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
    GO:0019899enzyme binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HSPA9           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for HSPA9:
     Decreased TP53 protein express  Decreased viability of wild-ty  Enable proliferation in B-Raf   Increased 8N DNA content 
     Synthetic lethal with Ras  Wnt reporter downregulated 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HSPA9

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA9:
    hsa-mir-324-3p (MIRT042957), hsa-mir-16-5p (MIRT031608), hsa-mir-615-3p (MIRT039907), hsa-mir-339-5p (MIRT042742), hsa-mir-1226-3p (MIRT036458), hsa-mir-320a (MIRT044460)

    Block miRNA regulation of human, mouse, rat HSPA9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA9 (see all 13):
    hsa-miR-217 hsa-miR-429 hsa-miR-767-3p hsa-miR-509-5p hsa-miR-708* hsa-miR-1301 hsa-miR-200c hsa-miR-873
    SwitchGear 3'UTR luciferase reporter plasmidHSPA9 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSPA9
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA9

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for HSPA9
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    GenScript: all cDNA clones in your preferred vector: HSPA9 (NM_004134)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA9

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12167) for HSPA9 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRP75_HUMAN, P38646: Mitochondrion. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS7684501
    GO:0005739mitochondrion TAS16130169
    GO:0042645mitochondrial nucleoid IDA18063578
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with HSPA9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA9 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    3Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Deadenylation-dependent mRNA decay
    RNA degradation0.48
    5Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with HSPA9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HSPA9
        Translational Control

    Selected GeneGo (Thomson Reuters) Pathways for HSPA9 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA9
        Parkin-Ubiquitin Proteasomal System pathway

    1 Reactome Pathway for HSPA9
        Mitochondrial protein import


    2 Kegg Pathways  (Kegg details for HSPA9):
        RNA degradation
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA9: 
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA9 (P386461, 2, 3 ENSP000002971854) via UniProtKB, MINT, STRING, and/or I2D (see all 779)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0005975carbohydrate metabolic process ----
    GO:0006457protein folding IEA--
    GO:0006611protein export from nucleus IEA--
    GO:0006626protein targeting to mitochondrion TAS--

    Find genes that share ontologies with HSPA9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA9 (GRP75)

    7 Novoseek inferred chemical compound relationships for HSPA9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 15.9 2 16220529 (1), 9504817 (1)
    ouabain 15 3 12433836 (2), 17172693 (1)
    atp 13.4 4 16220529 (1), 12488463 (1), 15724436 (1), 10221157 (1)
    glucose 0 11 15724436 (4), 19659607 (1), 12371145 (1), 11099777 (1) (see all 5)
    calcium 0 1 12687615 (1)
    tyrosine 0 6 11162655 (4)
    phosphatidylinositol 0 1 17635236 (1)



    Find genes that share compounds with HSPA9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA9 gene: 
    NM_004134.6  

    Unigene Cluster for HSPA9:

    Heat shock 70kDa protein 9 (mortalin)
    Hs.184233  [show with all ESTs]
    Unigene Representative Sequence: NM_004134
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297185(uc003ldf.3) ENST00000501917 ENST00000524109 ENST00000512328
    ENST00000507097(uc011cyw.2) ENST00000523929 ENST00000508003 ENST00000504902
    ENST00000507115 ENST00000505110 ENST00000504810 ENST00000506477 ENST00000507886

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HSPA9 (see all 13):
    hsa-miR-217 hsa-miR-429 hsa-miR-767-3p hsa-miR-509-5p hsa-miR-708* hsa-miR-1301 hsa-miR-200c hsa-miR-873
    SwitchGear 3'UTR luciferase reporter plasmidHSPA9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA9
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    Primer
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    OriGene qPCR primer pairs and template standards for HSPA9
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA9
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA9
      QuantiFast Probe-based Assays in human, mouse, rat HSPA9
    Flow Cytometry
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    Additional mRNA sequence: 

    AK222758.1 AK225488.1 AK293990.1 AK297795.1 AK297897.1 AK315177.1 BC000478.2 BC024034.2 
    BC030634.1 DQ185038.1 DQ480334.1 L11066.1 L15189.1 

    Selected DOTS entries (see all 45):

    DT.97836364  DT.95288765  DT.100887123  DT.120803652  DT.101977168  DT.92407569  DT.405321  DT.95288768 
    DT.97766955  DT.99991700  DT.120803655  DT.120803628  DT.120803672  DT.92325858  DT.92465522  DT.97836373 
    DT.99943195  DT.120803599  DT.100039307  DT.100887131  DT.100887134  DT.120803668  DT.120803688  DT.95128155 

    Selected AceView cDNA sequences (see all 1018):

    CA390667 BU192141 AA343673 AU131294 AA355094 BQ581502 BM464905 BQ632177 
    BU178246 CF125181 CA307074 BQ221313 BM836943 BQ917877 BU623801 AA343571 
    CD171890 BQ349108 CB158873 CA389144 BQ435446 BM835717 BP365324 BQ226897 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
    SP1:                          -     -     -                                   -                 -                                                               
    SP2:                          -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP3:                          -     -     -                                   -                                                                                 
    SP4:                                      -                                   -                                                                                 
    SP5:                          -     -     -                                                                                                                     

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for HSPA9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSPA9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTAGATG
    HSPA9 Expression
    About this image


    HSPA9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HSPA9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.184233
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA9: 
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA9 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa91 , 5 heat shock protein 91, 5 90.28(n)1
    98.38(a)1
      18 (18.80 cM)5
    155261  NM_010481.21  NP_034611.21 
     349374145 
    chicken
    (Gallus gallus)
    Aves HSPA91 heat shock 70kDa protein 9 (mortalin) 81.25(n)
    94.13(a)
      416183  NM_001006147.1  NP_001006147.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA96
    heat shock 70kDa protein 9 (mortalin)
    90(a)
    1 ↔ 1
    1(131017717-131036870)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspa9b-prov2 heat shock protein, 74 kDa, A 77.18(n)    BC045130.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hspa9b2 heat shock protein 9B 80.26(n)   373085  BC044175.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-51 Heat shock protein cognate 5 68.23(n)
    78.47(a)
      36583  NM_079017.2  NP_523741.2 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-61 hsp-6 66.77(n)
    76.92(a)
      178873  NM_071890.4  NP_504291.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSQ1(YLR369W)4
    SSC11
    Mitochondrial hsp70-type molecular chaperone, required more4
    SSC11
    62.85(n)1
    66.4(a)1
      12(859552-861525)4
    8535031  NP_012579.11  8510844 
     NP_013473.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons mtHsc70-11 mtHsc70-1 63.49(n)
    64.13(a)
      829947  NM_119952.3  NP_195504.2 
    rice
    (Oryza sativa)
    Liliopsida AK103835.12   -- 76.62(n)    AK103835.1 


    ENSEMBL Gene Tree for HSPA9 (if available)
    TreeFam Gene Tree for HSPA9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA9 gene
    HSPA82  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA142  HSPA22  HSPA1A2  
    15 SIMAP similar genes for HSPA9 using alignment to 9 protein entries:     GRP75_HUMAN (see all proteins):
    CIR1    HSP70-1    HSPA1L    HSPA5    HSPA2    HSPA1A
    HSPA8    HSPA1B    HSPA6    HSPA7    HSPA14    C8orf44
    HSPA13    HSPH1    HSPA4L

    Find genes that share paralogs with HSPA9           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for HSPA9
    PGOHUM00000234911 PGOHUM00000241118 PGOHUM00000263161


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA9 (see all 562)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344115391,2
    C--137894003(+) ATCAA-/ATGTCT 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs715744261,2
    C--137902869(+) TTGTG-/AAAAAA 1 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs360306971,2
    C--137905585(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1127808321,2
    C,F--137907026(+) CACCAT/CACCAA 1 -- int13Minor allele frequency- C:0.43CSA 7
    rs1135536481,2
    C--137907501(+) AATTT-/TG/TGTGT
    G
    /TGTGTGTG
    TGTGT
    2 -- int1 cds11CSA 2
    rs106940281,2
    C--137907502(+) TGTGTGT/-ACTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs412956931,2
    C,F--137908828(-) AAGGCG/AGGTGG 1 -- int15Minor allele frequency- A:0.01NS 190
    rs556638731,2
    C--137909357(+) AAAAA-/AA/A  
     AA
    /AAAA
    GCGCA
    2 -- int1 cds11NA 2
    rs344728001,2
    C,F--137909676(+) GAGAA-/GAATAATC 1 -- int13Minor allele frequency- GAA:0.38NA CSA 8
    rs100638091,2
    C,F,A,H--138165789(+) ACCATA/GTAACA 1 -- ds500115Minor allele frequency- G:0.03NS EA NA WA 1636

    HapMap Linkage Disequilibrium report for HSPA9 (137890571 - 137911318 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPA9: --
    Human Gene Mutation Database (HGMD): HSPA9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA9
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600548    OMIM disorders: --

    1 disease for HSPA9:    
    About MalaCards
    myotonic dystrophy type 2


    Find genes that share disorders with HSPA9           About GenesLikeMe

    6 Novoseek inferred disease relationships for HSPA9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 58 24 16817317 (1), 16619038 (1), 19280369 (1), 12687615 (1) (see all 20)
    cancer 31.6 30 14728808 (3), 17306926 (3), 17389721 (2), 17934217 (2) (see all 15)
    parkinson disease 27.8 4 19657588 (2), 20152901 (1), 18219256 (1)
    tumors 24.2 28 17306926 (3), 16425258 (3), 17934217 (3), 9417864 (2) (see all 10)
    breast carcinoma 0 1 16425258 (1)
    adenocarcinoma 0 2 15532096 (2)

    Genetic Association Database (GAD): HSPA9
    Human Genome Epidemiology (HuGE) Navigator: HSPA9 (4 documents)

    Export disorders for HSPA9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA9 gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with HSPA9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. (PubMed id 7684501)1, 2, 3 Domanico S.Z.... Pierce S.K. (Mol. Cell. Biol. 1993)
    2. Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease. (PubMed id 19657588)1, 4, 9 De Mena L....Alvarez V. (J Neural Transm 2009)
    3. Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone. (PubMed id 23462535)1, 2 Dores-Silva P.R.... Borges J.C. (Int. J. Biol. Macromol. 2013)
    4. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. (PubMed id 22114354)1, 2 Alkhaja A.K.... Deckers M. (Mol. Biol. Cell 2012)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)1, 2 Ji H.... Simpson R.J. (Electrophoresis 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3313 HGNC: 5244 AceView: HSPA9B Ensembl:ENSG00000113013 euGenes: HUgn3313
    ECgene: HSPA9 Kegg: 3313 H-InvDB: HSPA9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HSPA9 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa9b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA9 gene:
    Search GeneIP for patents involving HSPA9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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