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Aliases for HSPA9 Gene

Aliases for HSPA9 Gene

  • Heat Shock 70kDa Protein 9 (Mortalin) 2 3
  • HSPA9B 3 4 6
  • GRP75 3 4 6
  • 75 KDa Glucose-Regulated Protein 3 4
  • Peptide-Binding Protein 74 3 4
  • GRP-75 3 4
  • PBP74 3 4
  • MOT2 3 6
  • MOT 3 4
  • Epididymis Secretory Sperm Binding Protein Li 124m 3
  • Heat Shock 70kDa Protein 9B (Mortalin-2) 2
  • Catecholamine-Regulated Protein 40 3
  • Stress-70 Protein, Mitochondrial 3
  • Heat Shock 70 KDa Protein 9 4
  • Heat Shock 70kD Protein 9B 3
  • Mortalin, Perinuclear 3
  • P66-Mortalin 3
  • HEL-S-124m 3
  • Mortalin-2 3
  • Mortalin 4
  • Mt-HSP70 4
  • MTHSP75 3
  • CRP40 3
  • CSA 3

External Ids for HSPA9 Gene

Previous Symbols for HSPA9 Gene

  • HSPA9B

Summaries for HSPA9 Gene

Entrez Gene Summary for HSPA9 Gene

  • This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

GeneCards Summary for HSPA9 Gene

HSPA9 (Heat Shock 70kDa Protein 9 (Mortalin)) is a Protein Coding gene. Diseases associated with HSPA9 include breast ductal carcinoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Translational Control. GO annotations related to this gene include enzyme binding and unfolded protein binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA9 Gene

  • Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Wiki entry for HSPA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA9 Gene

Genomics for HSPA9 Gene

Genomic Location for HSPA9 Gene

Start:
138,554,882 bp from pter
End:
138,575,629 bp from pter
Size:
20,748 bases
Orientation:
Minus strand

Genomic View for HSPA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA9 Gene

Proteins for HSPA9 Gene

  • Protein details for HSPA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P38646-GRP75_HUMAN
    Recommended name:
    Stress-70 protein, mitochondrial
    Protein Accession:
    P38646
    Secondary Accessions:
    • B2RCM1
    • P30036
    • P31932
    • Q1HB43
    • Q53H23
    • Q6GU03
    • Q9BWB7
    • Q9UC56

    Protein attributes for HSPA9 Gene

    Size:
    679 amino acids
    Molecular mass:
    73680 Da
    Quaternary structure:
    • Interacts with FXN. Interacts with HSCB. Component of the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3 and associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2. Interacts with DNLZ, the interaction is required to prevent self-aggregation. Interacts with TESPA1.

    Three dimensional structures from OCA and Proteopedia for HSPA9 Gene

neXtProt entry for HSPA9 Gene

Proteomics data for HSPA9 Gene at MOPED

Post-translational modifications for HSPA9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys121, Lys368, and Lys646

Other Protein References for HSPA9 Gene

No data available for DME Specific Peptides for HSPA9 Gene

Domains for HSPA9 Gene

Gene Families for HSPA9 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA9 Gene

UniProtKB/Swiss-Prot:

GRP75_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • P38646
genes like me logo Genes that share domains with HSPA9: view

Function for HSPA9 Gene

Molecular function for HSPA9 Gene

UniProtKB/Swiss-Prot Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Gene Ontology (GO) - Molecular Function for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10411904
GO:0005524 ATP binding IEA --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
GO:0019899 enzyme binding --
GO:0031625 ubiquitin protein ligase binding IPI 19725078
genes like me logo Genes that share ontologies with HSPA9: view
genes like me logo Genes that share phenotypes with HSPA9: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA9 Gene

Localization for HSPA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA9 Gene

Mitochondrion. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA9 Gene COMPARTMENTS Subcellular localization image for HSPA9 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm TAS 7684501
GO:0005739 mitochondrion TAS 16130169
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HSPA9: view

Pathways for HSPA9 Gene

genes like me logo Genes that share pathways with HSPA9: view

Pathways by source for HSPA9 Gene

Gene Ontology (GO) - Biological Process for HSPA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0005975 carbohydrate metabolic process --
GO:0006457 protein folding IEA --
GO:0006611 protein export from nucleus IEA --
GO:0006626 protein targeting to mitochondrion TAS --
genes like me logo Genes that share ontologies with HSPA9: view

Compounds for HSPA9 Gene

(7) Novoseek inferred chemical compound relationships for HSPA9 Gene

Compound -log(P) Hits PubMed IDs
glyceraldehyde 3-phosphate 15.9 2
ouabain 15 3
atp 13.4 4
glucose 0 8
calcium 0 1
genes like me logo Genes that share compounds with HSPA9: view

Transcripts for HSPA9 Gene

Unigene Clusters for HSPA9 Gene

Heat shock 70kDa protein 9 (mortalin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - -
SP7:
SP8:
SP9: - - - -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - - - - -

Relevant External Links for HSPA9 Gene

GeneLoc Exon Structure for
HSPA9
ECgene alternative splicing isoforms for
HSPA9

Expression for HSPA9 Gene

mRNA expression in normal human tissues for HSPA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA9 Gene

SOURCE GeneReport for Unigene cluster for HSPA9 Gene Hs.184233

genes like me logo Genes that share expressions with HSPA9: view

Orthologs for HSPA9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA9 36
  • 99.85 (n)
  • 99.85 (a)
HSPA9 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA9 36
  • 92.69 (n)
  • 98.53 (a)
HSPA9 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA9 36
  • 92.73 (n)
  • 98.82 (a)
HSPA9 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa9 36
  • 90.28 (n)
  • 98.38 (a)
Hspa9 16
Hspa9 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA9 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa9 36
  • 90.62 (n)
  • 98.38 (a)
chicken
(Gallus gallus)
Aves HSPA9 36
  • 81.25 (n)
  • 94.13 (a)
HSPA9 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA9 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hspa9b-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa9 36
  • 78.16 (n)
  • 91.5 (a)
Str.4363 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.697 36
zebrafish
(Danio rerio)
Actinopterygii hspa9 36
  • 76.85 (n)
  • 89.51 (a)
hspa9 37
  • 86 (a)
OneToOne
hspa9b 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010876 36
  • 67.88 (n)
  • 80.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-5 36
  • 68.23 (n)
  • 78.47 (a)
Hsc70-5 37
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsp-6 36
  • 66.77 (n)
  • 76.92 (a)
hsp-6 37
  • 75 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR352C 36
  • 62.24 (n)
  • 68.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 37
  • 50 (a)
OneToMany
SSC1 36
  • 62.85 (n)
  • 66.4 (a)
SSQ1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22309g 36
  • 63.6 (n)
  • 67.9 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7686 36
thale cress
(Arabidopsis thaliana)
eudicotyledons mtHsc70-1 36
  • 63.49 (n)
  • 64.13 (a)
corn
(Zea mays)
Liliopsida Zm.700 36
rice
(Oryza sativa)
Liliopsida Os09g0491772 36
  • 62.13 (n)
  • 63.54 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08693 36
  • 61.61 (n)
  • 68.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssc1 36
  • 60.24 (n)
  • 63.48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4684 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
ManyToMany
Species with no ortholog for HSPA9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA9 Gene

ENSEMBL:
Gene Tree for HSPA9 (if available)
TreeFam:
Gene Tree for HSPA9 (if available)

Paralogs for HSPA9 Gene

Paralogs for HSPA9 Gene

Pseudogenes.org Pseudogenes for HSPA9 Gene

genes like me logo Genes that share paralogs with HSPA9: view

Variants for HSPA9 Gene

Sequence variations from dbSNP and Humsavar for HSPA9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7306 -- 138,555,420(+) AGACA(C/G)AGGGC utr-variant-3-prime
rs10117 -- 138,556,481(-) CATCA(C/T)TGAAG reference, synonymous-codon
rs11032 -- 138,555,754(+) TAAAA(C/T)AGTTA utr-variant-3-prime
rs185342 -- 138,573,377(+) ACTTC(C/G)Aggcc intron-variant
rs192278 -- 138,571,496(+) GGTAT(C/G)TTTGC intron-variant

Relevant External Links for HSPA9 Gene

HapMap Linkage Disequilibrium report
HSPA9
Human Gene Mutation Database (HGMD)
HSPA9

No data available for Structural Variations from Database of Genomic Variants (DGV) for HSPA9 Gene

Disorders for HSPA9 Gene

(1) MalaCards Diseases for HSPA9 Gene

Search for HSPA9 Gene in MalaCards »

(6) Novoseek inferred disease relationships for HSPA9 Gene

Disease -log(P) Hits PubMed IDs
shock 58 20
cancer 31.6 21
parkinson disease 27.8 4
tumors 24.2 18
breast carcinoma 0 1

Relevant External Links for HSPA9

Genetic Association Database (GAD)
HSPA9
Human Genome Epidemiology (HuGE) Navigator
HSPA9
genes like me logo Genes that share disorders with HSPA9: view

No data available for UniProtKB/Swiss-Prot for HSPA9 Gene

Publications for HSPA9 Gene

  1. Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease. (PMID: 19657588) De Mena L. … Alvarez V. (J Neural Transm 2009) 3 23 49
  2. Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. (PMID: 7684501) Domanico S.Z. … Pierce S.K. (Mol. Cell. Biol. 1993) 2 3 4
  3. Cloning and subcellular localization of human mitochondrial hsp70. (PMID: 7829505) Bhattacharyya T. … Morimoto R.I. (J. Biol. Chem. 1995) 3 4
  4. Kinetic and structural characterization of human mortalin. (PMID: 20152901) Luo W.I. … Cowan J.A. (Protein Expr. Purif. 2010) 3 23
  5. Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions. (PMID: 20153329) Iosefson O. … Azem A. (FEBS Lett. 2010) 3 23

Products for HSPA9 Gene

Sources for HSPA9 Gene

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