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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA8 Gene

protein-coding   GIFtS: 72
GCID: GC11M122969

Heat Shock 70kDa Protein 8

(Previous name: heat shock 70kD protein 8)
(Previous symbol: HSPA10)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 81 2     NIP712
HSPA101 2 3     Constitutive Heat Shock Protein 702
HSP732 3 5     Heat Shock 70kd Protein 102
HSC702 3     Heat Shock Cognate 71 KDa Protein2
Heat Shock 70kD Protein 81     Heat Shock Cognate Protein 542
HSC542     Lipopolysaccharide-Associated Protein 12
HSC712     LPS-Associated Protein 12
HSP712     N-Myristoyltransferase Inhibitor Protein 712
LAP12     Heat Shock 70 KDa Protein 83

External Ids:    HGNC: 52411   Entrez Gene: 33122   Ensembl: ENSG000001099717   OMIM: 6008165   UniProtKB: P111423   

Export aliases for HSPA8 gene to outside databases

Previous GC identifers: GC11M124929 GC11M124441 GC11M122962 GC11M122465 GC11M122436 GC11M122437 GC11M122439 GC11M122444 GC11M122450 GC11M122452 GC11M122454 GC11M122456 GC11M122458 GC11M122460 GC11M122463 GC11M122468 GC11M122934 GC11M122938 GC11M118870 GC11M122942 GC11M122947 GC11M122948 GC11M122952 GC11M122959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA8 Gene:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and
constitutively expressed members. This protein belongs to the latter group, which are also referred to as
heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct
folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of
membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for HSPA8 Gene: 
HSPA8 (heat shock 70kDa protein 8) is a protein-coding gene. Diseases associated with HSPA8 include inner ear disease, and autoimmune inner ear disease, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and MAPK signaling pathway. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is HSPA9.

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of
CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral
part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the
spliceosome assembly as it contacts all other components of the core complex

Gene Wiki entry for HSPA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA8 gene promoter:
         STAT1   Sp1   p300   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

HSPA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M122969:  view genomic region     (about GC identifiers)

Start:
122,928,197 bp from pter      End:
122,933,938 bp from pter
Size:
5,742 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142 (See protein sequence)
Recommended Name: Heat shock cognate 71 kDa protein  
Size: 646 amino acids; 70898 Da
Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,
HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1,
RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG.
Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7. Interacts with CITED1 (via
N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription
transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a
homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15
and HSPA8. Interacts with SV40 VP1. Interacts with TRIM5. Part of a complex composed at least of ASCL2,
C11orf30/EMSY, HCFC1, HSPA8, KIAA1967, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a
histone H3-specific methyltransferase activity
Subcellular location: Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules
containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the
nucleoli, upon heat shock
6/11 PDB 3D structures from and Proteopedia for HSPA8 (see all 11):
3AGY (3D)        3AGZ (3D)        3ESK (3D)        3FZF (3D)        3FZH (3D)        3FZK (3D)    
Secondary accessions: Q9H3R6
Alternative splicing: 2 isoforms:  P11142-1   P11142-2   

Explore the universe of human proteins at neXtProt for HSPA8: NX_P11142

Explore proteomics data for HSPA8 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylated
  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11142

  • HSPA8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA8 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006588.1  NP_694881.1  

    ENSEMBL proteins: 
     ENSP00000437125   ENSP00000437189   ENSP00000432083   ENSP00000404372   ENSP00000227378  
     ENSP00000433316   ENSP00000433584   ENSP00000435908   ENSP00000435019   ENSP00000432884  
     ENSP00000436762   ENSP00000435154   ENSP00000431641   ENSP00000436183   ENSP00000434415  
     ENSP00000434565   ENSP00000434851  
    Reactome Protein details: P11142
    Human Recombinant Protein Products for HSPA8: 
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    ProSpec Recombinant Protein for HSPA8
    Cloud-Clone Corp. Proteins for HSPA8 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000974Prp19 complex IDA--
    GO:0005622intracellular NAS8713105
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730nucleolus IDA--

    HSPA8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P11142

    ProtoNet protein and cluster: P11142

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
    Domain: The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the
    peptide-binding domain
    Similarity: Belongs to the heat shock protein 70 family


    HSPA8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP7C_HUMAN, P11142
    Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of
    CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral
    part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the
    spliceosome assembly as it contacts all other components of the core complex
    Induction: Constitutively synthesized

         Genatlas biochemistry entry for HSPA8:
    heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a
    stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10722728
    GO:0005524ATP binding IEA--
    GO:0042623ATPase activity, coupled NAS8530083
    GO:0051082unfolded protein binding IEA--
         
    HSPA8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA8:
     Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA8 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA8 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA8 About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Lysosome Vesicle Biogenesis0.39
    4Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    5Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA8
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HSPA8
        Cellular Transformation by HTLV1

    5/7 GeneGo (Thomson Reuters) Pathways for HSPA8 (see all 7)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    5/6 BioSystems Pathways for HSPA8 (see all 6)
        MAPK signaling pathway
    Diurnally regulated genes with circadian orthologs
    Parkin-Ubiquitin Proteasomal System pathway
    TGF-beta Receptor Signaling Pathway
    C-MYB transcription factor network


    5/18        Reactome Pathways for HSPA8 (see all 18)
        L1CAM interactions
    Developmental Biology
    Membrane Trafficking
    Transmission across Chemical Synapses
    Clathrin derived vesicle budding


    5/11         Kegg Pathways  (Kegg details for HSPA8) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1322 Interacting proteins for HSPA8 (P111421, 2, 3 ENSP000002273784) via UniProtKB, MINT, STRING, and/or I2D (see all 1322)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081072, 3, ENSP000003648024MINT-6735120 MINT-4050722 I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    ENSG00000215328P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    ENSG00000224501P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    ENSG00000231555P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006397mRNA processing IEA--
    GO:0006457protein folding NAS8530083
    GO:0006892post-Golgi vesicle-mediated transport TAS--

    HSPA8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPA8 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSPA8:
    Small Molecule - inhibitor
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    2 DrugBank Compounds for HSPA8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235

    10/117 Novoseek inferred chemical compound relationships for HSPA8 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 63.2 7 14579785 (2), 16311509 (1), 15358157 (1), 16173045 (1) (see all 5)
    17-(allylamino)-17-demethoxygeldanamycin 53.9 2 15774780 (1), 17409432 (1)
    geranylgeranylacetone 50.5 3 11119869 (1), 17684364 (1), 14605546 (1)
    atp 50.1 91 10493815 (4), 16141393 (4), 8702658 (4), 7547923 (4) (see all 38)
    radicicol 46.5 2 17409432 (1), 16173045 (1)
    sodium arsenite 46 1 10544156 (1)
    quercetin 42.4 14 9482255 (2), 8347809 (2), 9334813 (2), 19296652 (1) (see all 8)
    adp 36.6 28 1356434 (3), 10493815 (2), 16806043 (2), 9321400 (1) (see all 17)
    delta-12-pgj2 35.7 2 9824682 (2)
    cdcl2 32.1 3 15764298 (1), 11341981 (1), 7593327 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPA8 / HSP7C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for HSPA8 gene (2 alternative transcripts): 
    NM_006597.5  NM_153201.3  

    Unigene Cluster for HSPA8:

    Heat shock 70kDa protein 8
    Hs.180414  [show with all ESTs]
    Unigene Representative Sequence: BC042163
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000532636 ENST00000533540 ENST00000534624(uc001pyo.3 uc010rzu.2)
    ENST00000453788(uc001pyp.3) ENST00000532091(uc009zbc.3) ENST00000227378
    ENST00000534319 ENST00000526110 ENST00000524552 ENST00000526686 ENST00000533238
    ENST00000526862 ENST00000527983(uc009zbd.2) ENST00000528292 ENST00000532780(uc010rzv.1)
    ENST00000525463 ENST00000532167 ENST00000525624
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB034951.1 AB073886.1 AF217511.1 AF352832.1 AK000571.1 AK096100.1 AK129885.1 AK222628.1 
    AK222785.1 AK292067.1 AK300404.1 AK303935.1 AK310467.1 BC007276.1 BC008907.2 BC015699.1 
    BC016179.1 BC016660.1 BC019816.2 BC042163.1 

    24/212 DOTS entries (see all 212):

    DT.100741793  DT.100862687  DT.91861874  DT.120705014  DT.100846469  DT.100060526  DT.91769577  DT.100060520 
    DT.97869881  DT.100866889  DT.100637353  DT.120705101  DT.100741754  DT.91808254  DT.100741771  DT.120704813 
    DT.100741714  DT.95198199  DT.100741706  DT.100741806  DT.120705037  DT.100637324  DT.120704685  DT.120704654 

    24/2778 AceView cDNA sequences (see all 2778):

    CB155771 BM722507 AL711223 BP871692 BI858705 BX473878 BM564361 BP872879 
    CA427743 CD367867 AL709070 BE439883 AL518241 BM467941 AL535364 BP872103 
    BI089955 BQ344076 BE258489 BQ230222 BM914499 BM807291 BU180779 CA443431 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                -                                                     -                                                         
    SP2:                    -           -                                                     -                                                         
    SP3:                                -                                                     -           -     -     -     -     -                     
    SP4:                                -                                                                                                               
    SP5:                                                                                      -                 -     -                                 


    ECgene alternative splicing isoforms for HSPA8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA8 expression in normal human tissues (normalized intensities)      HSPA8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGAGGAA
    HSPA8 Expression
    About this image


    HSPA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells
     
     Tooth (Integumentary System)
             Dental Enamel

    See HSPA8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA8

    SOURCE GeneReport for Unigene cluster: Hs.180414

    UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA8: 
              Autophagy in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA8 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa81 , 5 heat shock protein 81, 5 89.53(n)1
    99.85(a)1
      9 (21.55 cM)5
    154811  NM_031165.41  NP_112442.21 
     408009845 
    chicken
    (Gallus gallus)
    Aves HSPA81 heat shock 70kDa protein 8 84.42(n)
    97.99(a)
      395853  NM_205003.1  NP_990334.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA86
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    99(a)
    90(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    LGa(3019773-3029849)
    LGf(897907-924982)
    African clawed frog
    (Xenopus laevis)
    Amphibia U55070.12   -- 82.44(n)    U55070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063228.12   -- 82.75(n)   30675  BC063228.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43
    Hsc70-11
    neurotransmitter secretion chaperone3
    Heat shock protein cognate 11
    86(a)
    (best of 11)3
    70.62(n)1
    80.81(a)1
      88E43
    395421  NM_079339.21  NP_524063.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-11 , 3 HSP-1 heat shock 70kd protein A3
    Protein HSP-11
    86(a)
    (best of 7)3
    73.45(n)1
    86.07(a)1
      IV(17279119-17281340)3
    1785071  NM_070667.31  NP_503068.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSB2(YNL209W)4
    SSA41
    Cytoplasmic ATPase that is a ribosome-associated molecular more4
    Ssa4p1
    64.9(n)1
    75.08(a)1
      14(252059-253900)4
    8568401  NP_011029.31  8555124 
     NP_014190.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons Hsp70b1 heat shock protein 70B 67.4(n)
    76.26(a)
      838174  NM_101471.2  NP_173055.1 
    rice
    (Oryza sativa)
    Liliopsida AK065431.12   -- 76.64(n)    AK065431.1 


    ENSEMBL Gene Tree for HSPA8 (if available)
    TreeFam Gene Tree for HSPA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA8 gene
    HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA132  HSPA22  HSPA1A2  
    18/19 SIMAP similar genes for HSPA8 using alignment to 16 protein entries:     HSP7C_HUMAN (see all proteins) (see all similar genes):
    LOC401308    HSP70-1    HSPA2    HSPA1A    LOC401309    HSPA1B
    HSPA6    HSPA1L    HSPA7    HSPA5    HSPA14    HSPA9
    HS24/P52    HS24/p52    HSPA13    HYOU1    HSPA4L    HSPH1

    HSPA8 for paralogs           About GeneDecksing


    5/30 Pseudogenes.org Pseudogenes for HSPA8 (see all 30)
    PGOHUM00000257785 PGOHUM00000239629 PGOHUM00000257950 PGOHUM00000257951 PGOHUM00000257952


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/307 SNPs in HSPA8 are shown (see all 307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0496204
    ----see VAR_0496202 F L mis40--------
    rs736105261,2
    C,F--122793468(+) CTTAAC/TTAACC 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1392232631,2
    --122793523(+) CTCAGA/GAAGAA 2 -- ds50010--------
    rs1423134601,2
    --122793544(+) ACAGGA/GCAGTG 2 -- ds50010--------
    rs1505047451,2
    --122793549(+) GCAGTA/GGCTCA 2 -- ds50010--------
    rs1394768331,2
    --122793660(+) TCCAGA/GAAAGC 2 -- ds50010--------
    rs1497440751,2
    C--122793679(+) CTAGGC/TAGGCT 2 -- ds50010--------
    rs1158727411,2
    F--122793795(+) CTCAAA/TGCTCT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1898027701,2
    --122793857(+) GCCCTC/TGTTAA 2 -- ds50010--------
    rs1822928381,2
    --122793858(+) CCCTTA/GTTAAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HSPA8 (122928197 - 122933938 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPA8: --

    Human Gene Mutation Database (HGMD): HSPA8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA8
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600816    OMIM disorders: --

    20/130 diseases for HSPA8 (see all 130):    About MalaCards
    inner ear disease    autoimmune inner ear disease    menieres disease    meniere's disease
    renal vascular disease    spinocerebellar ataxia type 17    lyme disease    skin tag
    borna disease    spinal-bulbar muscular atrophy    brain ischemia    primary hyperoxaluria
    thoracic aortic aneurysm    lichen planus    schistosomiasis    ischemia
    spondylitis    vascular disease    laryngeal carcinoma    cerebral infarction


    HSPA8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for HSPA8 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 94.4 1714 9563600 (6), 18282334 (6), 18601599 (5), 10397208 (5) (see all 99)
    tumors 44.6 98 16038410 (2), 8276657 (2), 14678977 (2), 12826079 (2) (see all 76)
    neurodegenerative diseases 44.5 3 18975920 (1), 18199697 (1)
    menieres disease 41.9 10 10983953 (2), 9508029 (1), 12170155 (1), 9023247 (1) (see all 8)
    necrosis 36.7 26 9338474 (2), 15507967 (2), 9459115 (1), 16487255 (1) (see all 24)
    ear diseases 36.7 4 11889388 (2), 12768679 (1), 10201752 (1)
    cancer 30.8 31 19802014 (2), 11350684 (2), 15741319 (2), 10705241 (1) (see all 28)
    ischemia 30.4 41 8431764 (4), 8361650 (4), 8360284 (4), 8515271 (4) (see all 20)
    hearing loss sensorineural 27.9 8 7546586 (2), 7872600 (1), 18259075 (1), 17434470 (1) (see all 7)
    cell damage 23.6 6 18336662 (1), 1656141 (1), 16883109 (1), 19232737 (1) (see all 5)

    Genetic Association Database (GAD): HSPA8
    Human Genome Epidemiology (HuGE) Navigator: HSPA8 (16 documents)

    Export disorders for HSPA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA8 gene, integrated from 9 sources (see all 1196):
    (articles sorted by number of sources associating them with HSPA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PubMed id 3037489)1, 2, 3 Dworniczak B.P. and Mirault M.-E. (1987)
    2. Molecular and functional characterization of HSC54, a novel variant of human heat shock cognate protein 70. (PubMed id 11093761)1, 2, 9 Tsukahara F.... Muraki T. (2000)
    3. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PubMed id 8530083)1, 3, 9 Tavaria M....Kola I. (1995)
    4. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)1, 2, 9 Takayama S.... Reed J.C. (1997)
    5. Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk. (PubMed id 14991745)1, 4, 9 Rusin M....Krawczyk Z. (2004)
    6. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (2013)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)1, 2 Grote M....LA1hrmann R. (2010)
    9. Genetic variations in HSPA8 gene associated with coro nary heart disease risk in a Chinese population. (PubMed id 20300519)1, 4 He M....Wu T. (2010)
    10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3312 HGNC: 5241 AceView: HSPA8 Ensembl:ENSG00000109971 euGenes: HUgn3312
    ECgene: HSPA8 Kegg: 3312 H-InvDB: HSPA8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA8 gene:
    Search GeneIP for patents involving HSPA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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