Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPA8 Gene

Aliases for HSPA8 Gene

  • Heat Shock 70kDa Protein 8 2 3
  • HSP73 3 4 6
  • Lipopolysaccharide-Associated Protein 1 3 4
  • LPS-Associated Protein 1 3 4
  • HSPA10 3 4
  • HSC70 3 4
  • LAP-1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 72p 3
  • N-Myristoyltransferase Inhibitor Protein 71 3
  • Constitutive Heat Shock Protein 70 3
  • Heat Shock Cognate 71 KDa Protein 3
  • Epididymis Luminal Protein 33 3
  • Heat Shock Cognate Protein 54 3
  • Heat Shock 70 KDa Protein 8 4
  • Heat Shock 70kd Protein 10 3
  • Heat Shock 70kD Protein 8 2
  • HEL-S-72p 3
  • HEL-33 3
  • HSC54 3
  • HSC71 3
  • HSP71 3
  • NIP71 3
  • LAP1 3

External Ids for HSPA8 Gene

Previous Symbols for HSPA8 Gene

  • HSPA10

Summaries for HSPA8 Gene

Entrez Gene Summary for HSPA8 Gene

  • This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HSPA8 Gene

HSPA8 (Heat Shock 70kDa Protein 8) is a Protein Coding gene. Diseases associated with HSPA8 include inner ear disease and autoimmune inner ear disease. Among its related pathways are MAPK signaling pathway and L1CAM interactions. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA8 Gene

  • Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.

Gene Wiki entry for HSPA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA8 Gene

Genomics for HSPA8 Gene

Genomic Location for HSPA8 Gene

Start:
123,057,489 bp from pter
End:
123,063,230 bp from pter
Size:
5,742 bases
Orientation:
Minus strand

Genomic View for HSPA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA8 Gene

Regulatory Elements for HSPA8 Gene

Proteins for HSPA8 Gene

  • Protein details for HSPA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11142-HSP7C_HUMAN
    Recommended name:
    Heat shock cognate 71 kDa protein
    Protein Accession:
    P11142
    Secondary Accessions:
    • Q9H3R6

    Protein attributes for HSPA8 Gene

    Size:
    646 amino acids
    Molecular mass:
    70898 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7 and DNAJB14 (via J domain). Interacts (via C-terminus) with the E3 ligase CHIP forming a 210 kDa complex of one CHIP and two HSPA8 molecules. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts with SV40 VP1. Interacts with TRIM5. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with METTL21A. Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1. Interacts with PARK2. Interacts with FOXP3.

    Three dimensional structures from OCA and Proteopedia for HSPA8 Gene

    Alternative splice isoforms for HSPA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA8 Gene

Proteomics data for HSPA8 Gene at MOPED

Post-translational modifications for HSPA8 Gene

  • Acetylated.
  • ISGylated.
  • Trimethylation at Lys-561 reduces fibrillar SNCA binding
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys25, Lys56, Lys71, Lys88, Lys108, Lys112, Lys126, Lys128, Lys137, Lys159, Lys187, Lys188, Lys246, Lys319, Lys325, Lys328, Lys345, Lys348, Lys357, Lys361, Lys423, Lys451, Lys458, Lys507, Lys512, Lys524, Lys539, Lys573, Lys583, Lys597, and Lys601

No data available for DME Specific Peptides for HSPA8 Gene

Domains for HSPA8 Gene

Gene Families for HSPA8 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA8 Gene

UniProtKB/Swiss-Prot:

HSP7C_HUMAN
Domain:
  • The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.:
    • P11142
Family:
  • Belongs to the heat shock protein 70 family.:
    • P11142
genes like me logo Genes that share domains with HSPA8: view

Function for HSPA8 Gene

Molecular function for HSPA8 Gene

GENATLAS Biochemistry: heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program
UniProtKB/Swiss-Prot Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
UniProtKB/Swiss-Prot Induction: Constitutively synthesized

Gene Ontology (GO) - Molecular Function for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0005515 protein binding IPI 10722728
GO:0005524 ATP binding IDA 23921388
GO:0016887 ATPase activity IDA 23921388
GO:0019899 enzyme binding IPI 23921388
genes like me logo Genes that share ontologies with HSPA8: view

Phenotypes for HSPA8 Gene

genes like me logo Genes that share phenotypes with HSPA8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA8 Gene

Localization for HSPA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA8 Gene

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA8 Gene COMPARTMENTS Subcellular localization image for HSPA8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
vacuole 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0000974 Prp19 complex IDA 20176811
GO:0005615 extracellular space IDA 16502470
GO:0005622 intracellular NAS 8713105
GO:0005634 nucleus IDA 20176811
genes like me logo Genes that share ontologies with HSPA8: view

Pathways for HSPA8 Gene

genes like me logo Genes that share pathways with HSPA8: view

Gene Ontology (GO) - Biological Process for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0000902 cell morphogenesis --
GO:0006200 obsolete ATP catabolic process --
GO:0006351 transcription, DNA-templated IEA --
GO:0006397 mRNA processing --
genes like me logo Genes that share ontologies with HSPA8: view

Compounds for HSPA8 Gene

(2) Drugbank Compounds for HSPA8 Gene

(117) Novoseek inferred chemical compound relationships for HSPA8 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 63.2 6
17-(allylamino)-17-demethoxygeldanamycin 53.9 2
geranylgeranylacetone 50.5 3
atp 50.1 64
radicicol 46.5 2
genes like me logo Genes that share compounds with HSPA8: view

Transcripts for HSPA8 Gene

Unigene Clusters for HSPA8 Gene

Heat shock 70kDa protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - - -
SP3: - - - - - - -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for HSPA8 Gene

GeneLoc Exon Structure for
HSPA8
ECgene alternative splicing isoforms for
HSPA8

Expression for HSPA8 Gene

mRNA expression in normal human tissues for HSPA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA8 Gene

SOURCE GeneReport for Unigene cluster for HSPA8 Gene Hs.180414

mRNA Expression by UniProt/SwissProt for HSPA8 Gene

P11142-HSP7C_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with HSPA8: view

Orthologs for HSPA8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA8 36
  • 99.33 (n)
  • 100 (a)
HSPA8 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA8 36
  • 92.12 (n)
  • 99.84 (a)
HSPA8 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA8 36
  • 91.07 (n)
  • 100 (a)
HSPA8 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa8 36
  • 89.53 (n)
  • 99.85 (a)
Hspa8 16
Hspa8 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa8 36
  • 89.78 (n)
  • 99.85 (a)
chicken
(Gallus gallus)
Aves HSPA8 36
  • 84.42 (n)
  • 97.99 (a)
HSPA8 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA8 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa8 36
  • 82.3 (n)
  • 96.9 (a)
Str.5671 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
hspa8 36
  • 82.54 (n)
  • 95.76 (a)
hspa8 37
  • 95 (a)
OneToMany
HSPA8 (1 of 2) 37
  • 93 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004944 36
  • 72.33 (n)
  • 86.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 36
  • 71.41 (n)
  • 82.19 (a)
Hsc70-1 37
  • 81 (a)
ManyToMany
Hsc70-4 37
  • 85 (a)
ManyToMany
Hsc70-4 38
  • 86 (a)
Hsc70-3 38
  • 64 (a)
Hsp70Aa 38
  • 76 (a)
Hsc70-1 38
  • 82 (a)
Hsp70Bb 38
  • 76 (a)
Hsp70Bc 38
  • 76 (a)
Hsc70-2 38
  • 73 (a)
Hsp68 38
  • 71 (a)
Hsp70Ba 38
  • 76 (a)
CG7182 38
  • 25 (a)
Hsp70Ab 38
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36
  • 74.01 (n)
  • 86.62 (a)
hsp-1 37
  • 86 (a)
OneToMany
F44E5.4 38
  • 69 (a)
hsp-70 38
  • 68 (a)
F44E5.5 38
  • 69 (a)
hsp-3 38
  • 63 (a)
hsp-1 38
  • 86 (a)
hsp-4 38
  • 63 (a)
hsp-2 38
  • 75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 37
  • 76 (a)
OneToMany
SSB2 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09440 36
  • 70.66 (n)
  • 78.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2748 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 37
  • 86 (a)
ManyToMany
CSA.971 37
  • 79 (a)
ManyToMany
Species with no ortholog for HSPA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA8 Gene

ENSEMBL:
Gene Tree for HSPA8 (if available)
TreeFam:
Gene Tree for HSPA8 (if available)

Paralogs for HSPA8 Gene

Paralogs for HSPA8 Gene

genes like me logo Genes that share paralogs with HSPA8: view

Variants for HSPA8 Gene

Sequence variations from dbSNP and Humsavar for HSPA8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3168111 -- 123,057,497(-) TTGGC(A/C)CCATA utr-variant-3-prime
rs4114918 -- 123,057,524(+) TTAAG(A/G)CATTG utr-variant-3-prime
rs7948948 -- 123,057,467(+) GGGAG(A/G)TTATT downstream-variant-500B
rs7949127 -- 123,057,408(+) GGAAG(A/G)AGAAA downstream-variant-500B
rs7949220 -- 123,057,418(+) AGTAA(G/T)AGTCA downstream-variant-500B

Relevant External Links for HSPA8 Gene

HapMap Linkage Disequilibrium report
HSPA8
Human Gene Mutation Database (HGMD)
HSPA8

No data available for Structural Variations from Database of Genomic Variants (DGV) for HSPA8 Gene

Disorders for HSPA8 Gene

(92) Novoseek inferred disease relationships for HSPA8 Gene

Disease -log(P) Hits PubMed IDs
shock 94.4 249
tumors 44.6 84
neurodegenerative diseases 44.5 2
menieres disease 41.9 9
necrosis 36.7 26

Relevant External Links for HSPA8

Genetic Association Database (GAD)
HSPA8
Human Genome Epidemiology (HuGE) Navigator
HSPA8
genes like me logo Genes that share disorders with HSPA8: view

No data available for UniProtKB/Swiss-Prot for HSPA8 Gene

Publications for HSPA8 Gene

  1. Molecular and functional characterization of HSC54, a novel variant of human heat shock cognate protein 70. (PMID: 11093761) Tsukahara F. … Muraki T. (Mol. Pharmacol. 2000) 3 4 23
  2. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PMID: 8530083) Tavaria M. … Kola I. (Genomics 1995) 2 3 23
  3. Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk. (PMID: 14991745) Rusin M. … Krawczyk Z. (Mol. Carcinog. 2004) 3 23 49
  4. Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PMID: 3037489) Dworniczak B.P. … Mirault M.-E. (Nucleic Acids Res. 1987) 2 3 4
  5. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PMID: 1286667) Rasmussen H.H. … Vandekerckhove J. (Electrophoresis 1992) 3 4

Products for HSPA8 Gene

  • Addgene plasmids for HSPA8

Sources for HSPA8 Gene

Back to Top

Content