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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPA8 Gene

protein-coding GIFtS: 71
GCID: GC11M122959

heat shock 70kDa protein 8

(Previous name: heat shock 70kD protein 8 )
(Previous symbol: HSPA10)

Explore 147 diseases affiliated with
HSPA8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 8¹ ²		NIP71²
HSP73¹ ² ³ ⁵		Constitutive Heat Shock Protein 70²
HSC70¹ ² ³		Heat Shock 70kd Protein 10²
HSPA10¹ ² ³		Heat Shock Cognate 71 KDa Protein²
HSC71¹ ²		Heat Shock Cognate Protein 54²
Heat Shock 70kD Protein 8¹		Lipopolysaccharide-Associated Protein 1²
HSC54²		LPS-Associated Protein 1²
HSP71²		N-Myristoyltransferase Inhibitor Protein 71²
LAP1²		Heat Shock 70 KDa Protein 8³

External Ids:	HGNC: 5241¹	Entrez Gene: 3312²	Ensembl: ENSG00000109971⁷	OMIM: 600816⁵	UniProtKB: P11142³

Export aliases for HSPA8 gene to outside databases

Previous GC identifers: GC11M124929 GC11M124441 GC11M122962 GC11M122465 GC11M122436 GC11M122437 GC11M122439 GC11M122444 GC11M122450 GC11M122452 GC11M122454 GC11M122456 GC11M122458 GC11M122460 GC11M122463 GC11M122468 GC11M122934 GC11M122938 GC11M118870 GC11M122942 GC11M122947 GC11M122948 GC11M122952

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA8:

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively

expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate

proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also

functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through

the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142

Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of

CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of

the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome

assembly as it contacts all other components of the core complex

Gene Wiki entry for HSPA8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPA8 gene promoter:
STAT1 Sp1 p300 STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPA8 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPA8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1

HSPA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA8 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M122959: view genomic region (about GC identifiers)

Start:	122,928,197 bp from pter	End:	122,933,938 bp from pter
Size:	5,742 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142 (See protein sequence)

Recommended Name: Heat shock cognate 71 kDa protein

Size: 646 amino acids; 70898 Da

Subunit: Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1,

HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0,

RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG. Interacts with

HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7. Interacts with CITED1 (via N-terminus); the

interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L,

PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts with SV40 VP1.

Interacts with TRIM5

Subcellular location: Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing

untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat

shock

6/10 PDB 3D structures from and Proteopedia for HSPA8 (see all 10):

3AGY (3D)

3AGZ (3D)

3ESK (3D)

3FZF (3D)

3FZH (3D)

3FZK (3D)

Secondary accessions: Q9H3R6

Alternative splicing: 2 isoforms: P11142-1 P11142-2

Explore the universe of human proteins at neXtProt for HSPA8: NX_P11142

Post-translational modifications:

Acetylated¹

ISGylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11142

HSPA8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_006588.1 NP_694881.1

ENSEMBL proteins:

ENSP00000437125 ENSP00000437189 ENSP00000432083 ENSP00000404372 ENSP00000227378

ENSP00000433316 ENSP00000433584 ENSP00000435908 ENSP00000435019 ENSP00000432884

ENSP00000433978 ENSP00000436762 ENSP00000435154 ENSP00000431641 ENSP00000436183

ENSP00000434415 ENSP00000434565 ENSP00000434851

Reactome Protein details: P11142
Human Recombinant Protein Products:

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	Novus Biologicals HSPA8 Proteins Novus Biologicals HSPA8 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HSPA8
	Uscn Proteins for HSPA8

Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000974	Prp19 complex	IDA	--
GO:0005622	intracellular	NAS	8713105
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005681	spliceosomal complex	IEA	--

HSPA8 for ontologies About GeneDecksing

HSPA8 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HSPA8 (HSPA8/HSC71)
	Cell Signaling Technology (CST) Antibodies for HSPA8 (HSC70)
	OriGene Antibodies (see all 6): HSPA8 OriGene Custom Antibody Services for HSPA8
	GenScript Custom Superior Antibodies Services for HSPA8
	Novus Biologicals HSPA8 Antibodies
	Abcam antibodies for HSPA8
	Uscn Antibodies for HSPA8
	ThermoFisher Antibody for HSPA8

Assay Products for HSPA8:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSPA8
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HSPA8

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA8 for domains About GeneDecksing

2 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR013126 Hsp_70_fam

Graphical View of Domain Structure for InterPro Entry P11142

ProtoNet protein and cluster: P11142

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142

Domain: The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding

domain

Similarity: Belongs to the heat shock protein 70 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142

Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of

CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of

the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome

assembly as it contacts all other components of the core complex

Induction: Constitutively synthesized

Genatlas biochemistry entry for HSPA8:

heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a

stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HSPA8 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA8
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA8 (see all 30):
		hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-3190 hsa-miR-3692 hsa-miR-1297 hsa-miR-641 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA8 (see all 7) OriGene shRNA RFP: HSPA8 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA8

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSPA8

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA8 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA8 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HSPA8 (NM_006597)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA8

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSPA8
		Search LifeMap BioReagents cell lines for HSPA8

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HSPA8

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005515	protein binding	IPI	15936278
GO:0005524	ATP binding	IEA	--
GO:0042623	ATPase activity, coupled	NAS	8530083
GO:0043531	ADP binding	--	--

HSPA8 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HSPA8:

Decreased viability of wild-ty

Increased G1 DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Clathrin derived vesicle budding

	Clathrin derived vesicle budding	1.00			Golgi Associated Vesicle Biogenesis	0.89
	trans-Golgi Network Vesicle Budding	1.00			Lysosome Vesicle Biogenesis	0.39

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Regulation of degradation of wt-CFTR

Regulation of degradation of wt-CFTR

1.00

Regulation of degradation of deltaF508 CFTR in CF

0.59

GABA synthesis, release, reuptake and degradation

GABA synthesis, release, reuptake and degradation

1.00

Neurotransmitter Release Cycle

0.53

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSPA8

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HSPA8

Cellular Transformation by HTLV1

5/7 GeneGo (Thomson Reuters) Pathways for HSPA8 (see all 7)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Regulation of degradation of deltaF508 CFTR in CF
	CFTR folding and maturation (norm and CF)
	Proteolysis Putative ubiquitin pathway

5/6 BioSystems Pathways for HSPA8 (see all 6)

	Diurnally regulated genes with circadian orthologs
	MAPK signaling pathway
	Parkin-Ubiquitin Proteasomal System pathway
	TGF-beta Receptor Signaling Pathway
	C-MYB transcription factor network

5/15 Reactome Pathways for HSPA8 (see all 15)

	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Membrane Trafficking
	Transmission across Chemical Synapses
	Clathrin derived vesicle budding
	GABA synthesis, release, reuptake and degradation

5/8 Kegg Pathways (Kegg details for HSPA8) (see all 8):

	Spliceosome
	MAPK signaling pathway
	Protein processing in endoplasmic reticulum
	Endocytosis
	Antigen processing and presentation

HSPA8 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA8

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1260 Interacting proteins for HSPA8 (P11142^{1, 2, 3} ENSP00000227378⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1260)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG1	Q99933²^,³	MINT-7265483 MINT-7265269 MINT-7265281 MINT-7265310 MINT-7265364 MINT-7265296 MINT-7265351 MINT-7265464 MINT-7265324 MINT-7265339 I2D: score=4
HIST1H4A	P62805³	I2D: score=2
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006397	mRNA processing	IEA	--
GO:0006457	protein folding	NAS	8530083
GO:0006892	post-Golgi vesicle-mediated transport	TAS	--
GO:0006986	response to unfolded protein	NAS	11093761

HSPA8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPA8 for compounds About GeneDecksing

EMD Millipore small molecules for HSPA8:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA8

2 DrugBank Compounds for HSPA8 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	--	--	target	--	10592235
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	10592235

10/117 Novoseek chemical compound relationships for HSPA8 gene (see all 117) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
geldanamycin	63.2	7	14579785 (2), 16311509 (1), 15358157 (1), 16173045 (1) (see all 5)
17-(allylamino)-17-demethoxygeldanamycin	53.9	2	15774780 (1), 17409432 (1)
geranylgeranylacetone	50.5	3	11119869 (1), 17684364 (1), 14605546 (1)
atp	50.1	91	10493815 (4), 16141393 (4), 8702658 (4), 7547923 (4) (see all 38)
radicicol	46.5	2	17409432 (1), 16173045 (1)
sodium arsenite	46	1	10544156 (1)
quercetin	42.4	14	9482255 (2), 8347809 (2), 9334813 (2), 19296652 (1) (see all 8)
adp	36.6	28	1356434 (3), 10493815 (2), 16806043 (2), 9321400 (1) (see all 17)
delta-12-pgj2	35.7	2	9824682 (2)
cdcl2	32.1	3	15764298 (1), 11341981 (1), 7593327 (1)

Search CenterWatch for drugs/clinical trials and news about HSPA8 / HSP7C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPA8 gene (2 alternative transcripts):

NM_006597.4 NM_153201.2

Unigene Cluster for HSPA8:

Heat shock 70kDa protein 8

Hs.180414 [show with all ESTs]

Unigene Representative Sequence: BC042163

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000532636 ENST00000533540 ENST00000534624(uc001pyo.3 uc010rzu.2)

ENST00000453788(uc001pyp.3) ENST00000532091(uc009zbc.3) ENST00000227378

ENST00000534319 ENST00000526110 ENST00000524552 ENST00000526686 ENST00000533238

ENST00000526862 ENST00000527983(uc009zbd.2) ENST00000528292 ENST00000532780(uc010rzv.1)

ENST00000532007 ENST00000525463 ENST00000526108

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HSPA8 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA8
		8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA8 (see all 30):
		hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-3190 hsa-miR-3692 hsa-miR-1297 hsa-miR-641 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: HSPA8 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA8 (see all 7) OriGene shRNA RFP: HSPA8 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA8

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA8 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA8 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HSPA8 (NM_006597)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA8
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA8

Additional cDNA sequence:

AB034951.1 AB073886.1 AF217511.1 AF352832.1 AK000571.1 AK096100.1 AK129885.1 AK222628.1

AK222785.1 AK292067.1 AK300404.1 AK303935.1 AK310467.1 BC007276.1 BC008907.2 BC015699.1

BC016179.1 BC016660.1 BC019816.2 BC042163.1

24/220 DOTS entries (see all 220):

DT.100741793 DT.100862687 DT.91861874 DT.100060526 DT.100846469 DT.120705014 DT.91769577 DT.100060520

DT.97869881 DT.100866889 DT.100637353 DT.120705101 DT.100741771 DT.100741754 DT.91808254 DT.100741714

DT.100741706 DT.120704813 DT.95198199 DT.100741806 DT.120705037 DT.100637324 DT.120704685 DT.91902780

24/2778 AceView cDNA sequences (see all 2778):

BU934978 BM772649 BQ893029 AL534845 AA354777 BQ218363 BP873069 NM_153201

BP871511 BP872714 CD243044 AL047076 BM773130 BM847734 BM795395 CB134774

BM973625 AF352832 AI753157 BQ048957 CB135121 BX957093 AA379526 AA227205

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	·	10d	^	11a	·	11b	^	12	^	13a	·	13b	·	13c
SP1:											-																		-
SP2:							-				-																		-
SP3:											-																		-				-		-		-		-		-
SP4:											-
SP5:																													-						-		-

ECgene alternative splicing isoforms for HSPA8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGAGGAA

About this image

HSPA8 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPA8

SOURCE GeneReport for Unigene cluster: Hs.180414

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA8:

Autophagy in human mouse rat

Cellular Stress Responses in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA8 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSPA8¹	heat shock 70kDa protein 8	84.42(n) 97.99(a)		395853 NM_205003.1 NP_990334.1
lizard (Anolis carolinensis)	Reptilia	HSPA8⁶	--	99(a)	1 ↔ 1	LGa(3019773-3025106)
African clawed frog (Xenopus laevis)	Amphibia	U55070.1²	--	82.44(n)		U55070.1
zebrafish (Danio rerio)	Actinopterygii	BC063228.1²	--	82.75(n)		30675 BC063228.1
fruit fly (Drosophila melanogaster)	Insecta	Hsc70-4³ Hsc70-1¹	neurotransmitter secretion chaperone³ Heat shock protein cognate 1¹	86(a) (best of 11)³ 70.62(n)¹ 80.81(a)¹		88E4³ 39542¹ NM_079339.2¹ NP_524063.1¹
worm (Caenorhabditis elegans)	Secernentea	hsp-1^{1 , 3}	HSP-1 heat shock 70kd protein A³ Protein HSP-1¹	86(a) (best of 7)³ 73.45(n)¹ 86.07(a)¹		IV(17279119-17281340)³ 178507¹ NM_070667.3¹ NP_503068.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SSB2(YNL209W)⁴ SSA4¹	Cytoplasmic ATPase that is a ribosome-associated molecular more⁴ Ssa4p¹	64.9(n)¹ 75.08(a)¹		14(252059-253900)⁴ 856840¹ NP_011029.3¹ 855512⁴ NP_014190.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	Hsp70b¹	heat shock protein 70B	67.4(n) 76.26(a)		838174 NM_101471.2 NP_173055.1
rice (Oryza sativa)	Liliopsida	AK065431.1²	--	76.64(n)		AK065431.1

ENSEMBL Gene Tree for HSPA8 (if available)
TreeFam Gene Tree for HSPA8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPA8 gene

HSPA5² HSPA1L² HSPA1B² HSPA6² HSPA14² HSPA13² HSPA1A²

18/19 SIMAP similar genes for HSPA8 using alignment to 17 protein entries: HSP7C_HUMAN (see all proteins) (see all similar genes):

LOC401308 HSP70-1 HSPA2 LOC401309 HSPA6 HSPA1A

HSPA1L HSPA1B HSPA7 HSPA5 HSPA14 HSPA9

HS24/P52 HS24/p52 HSPA13 HYOU1 HSPA4L HSPA4

HSPA8 for paralogs About GeneDecksing

5/30 Pseudogenes.org Pseudogenes for HSPA8 (see all 30)
PGOHUM00000257785 PGOHUM00000239629 PGOHUM00000257950 PGOHUM00000257951 PGOHUM00000257952

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73610526^1,2	C,	--	118869781(+)	`CTTAAC/TTAACC`	2	--	ds500¹		1		WA	2
rs3168111^1,2	C	--	118870283(-)	`TTGGCA/CCCATA`	2	--	ut3¹ ese³		0	--	--	--	--
rs79688008^1,2	C,F,	--	118870784(+)	`GATACT/CAAAAG`	2	--	int¹		1		WA	118
rs201607928^1,2	C	--	118871031(-)	`TTTGTG/TTNNNN`	2	--	int¹		0	--	--	--	--
rs11551598^1,2	C,H	--	118871566(-)	`GCAAGT/CTTGAA`	4	/L /F	mis¹		5		NS EA NA	408
rs77171215^1,2		--	118871624(+)	`TTGGTA/GGGAAA`	2	--	int¹		1		NA	120
rs1381245^1,2	H	--	118871733(+)	`cataaG/Aacttt`	2	--	int¹		4		NS EA	418
rs76450893^1,2		--	118871777(+)	`CATCAT/AAGCGA`	2	--	int¹		1		WA	118
rs111548556^1,2	C	--	118872120(+)	`CTATCT/ACTCGC`	2	--	int¹		1		CSA	1
rs202196042^1,2	C	--	118872189(+)	`TGTTTA/GANNNN`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HSPA8 (122928197 - 122933938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPA8: --
Human Gene Mutation Database (HGMD): HSPA8

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA8 for disorders           About GeneDecksing

OMIM gene information: 600816    OMIM disorders: --

20/147 diseases for HSPA8 (see all 147):    About MalaCards

spinal-bulbar muscular atrophy inner ear disease autoimmune inner ear disease human t-cell leukemia virus type 1

spinocerebellar ataxia type 17 lichen planus thoracic aortic aneurysm hearing loss

oral lichen planus pre-eclampsia myocardial infarction atrial fibrillation

sensorineural hearing loss acute myocardial infarction aortic aneurysm skin tag

multiple endocrine neoplasia inflammatory bowel disease menieres disease meniere's disease

10/92 Novoseek disease relationships for HSPA8 gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	94.4	1714	9563600 (6), 18282334 (6), 18601599 (5), 10397208 (5) (see all 99)
tumors	44.6	98	16038410 (2), 8276657 (2), 14678977 (2), 12826079 (2) (see all 76)
neurodegenerative diseases	44.5	3	18975920 (1), 18199697 (1)
menieres disease	41.9	10	10983953 (2), 9508029 (1), 12170155 (1), 9023247 (1) (see all 8)
necrosis	36.7	26	9338474 (2), 15507967 (2), 9459115 (1), 16487255 (1) (see all 24)
ear diseases	36.7	4	11889388 (2), 12768679 (1), 10201752 (1)
cancer	30.8	31	19802014 (2), 11350684 (2), 15741319 (2), 10705241 (1) (see all 28)
ischemia	30.4	41	8431764 (4), 8361650 (4), 8360284 (4), 8515271 (4) (see all 20)
hearing loss sensorineural	27.9	8	7546586 (2), 7872600 (1), 18259075 (1), 17434470 (1) (see all 7)
cell damage	23.6	6	18336662 (1), 1656141 (1), 16883109 (1), 19232737 (1) (see all 5)

Genetic Association Database (GAD): HSPA8
Human Genome Epidemiology (HuGE) Navigator: HSPA8 (16 documents)

Export disorders for HSPA8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSPA8 gene, integrated from 9 sources (see all 1150):
(articles sorted by number of sources associating them with HSPA8)

Utopia: connect your pdf to the dynamic
world of online information

Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PubMed id 3037489)^{1, 2, 3} Dworniczak B.P. and Mirault M.-E. (1987)
Molecular and functional characterization of HSC54, a novel variant of human heat shock cognate protein 70. (PubMed id 11093761)^{1, 2, 9} Tsukahara F.... Muraki T. (2000)
Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PubMed id 8530083)^{1, 3, 9} Tavaria M....Kola I. (1995)
BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)^{1, 2, 9} Takayama S.... Reed J.C. (1997)
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk. (PubMed id 14991745)^{1, 4, 9} Rusin M....Krawczyk Z. (2004)
Molecular architecture of the human Prp19/CDC5L compl ex. (PubMed id 20176811)^{1, 2} Grote M....LA1hrmann R. (2010)
Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)^{1, 2} Joeson L.... Nielsen F.C. (2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets. (PubMed id 16815975)^{1, 2} Wong J.J....Chin K.C. (2006)
Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. (PubMed id 15963462)^{1, 2} Nellist M....Luider T.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3312	HGNC: 5241	AceView: HSPA8	Ensembl:ENSG00000109971	euGenes: HUgn3312
ECgene: HSPA8	Kegg: 3312	H-InvDB: HSPA8

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSPA8	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPA8	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HSPA8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HSPA8 gene:
Search GeneIP for patents involving HSPA8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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heat shock 70kDa protein 8

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HSPA8 Gene

heat shock 70kDa protein 8

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