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HSPA8 Gene

protein-coding   GIFtS: 74
GCID: GC11M122982

Heat Shock 70kDa Protein 8

(Previous name: heat shock 70kD protein 8)
(Previous symbol: HSPA10)
  See HSPA8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Heat Shock 70kDa Protein 81 2     NIP712
HSPA101 2 3     Constitutive Heat Shock Protein 702
HSP732 3 5     Epididymis Luminal Protein 332
HSC702 3     Epididymis Secretory Sperm Binding Protein Li 72p2
Heat Shock 70kD Protein 81     Heat Shock 70kd Protein 102
HEL-332     Heat Shock Cognate 71 KDa Protein2
HEL-S-72p2     Heat Shock Cognate Protein 542
HSC542     Lipopolysaccharide-Associated Protein 12
HSC712     LPS-Associated Protein 12
HSP712     N-Myristoyltransferase Inhibitor Protein 712
LAP12     Heat Shock 70 KDa Protein 83

External Ids:    HGNC: 52411   Entrez Gene: 33122   Ensembl: ENSG000001099717   OMIM: 6008165   UniProtKB: P111423   
ORGUL members:         

Export aliases for HSPA8 gene to outside databases

Previous GC identifers: GC11M124929 GC11M124441 GC11M122962 GC11M122465 GC11M122436 GC11M122437 GC11M122439 GC11M122444 GC11M122450 GC11M122452 GC11M122454 GC11M122456 GC11M122458 GC11M122460 GC11M122463 GC11M122468 GC11M122934 GC11M122938 GC11M118870 GC11M122942 GC11M122947 GC11M122948 GC11M122952 GC11M122959 GC11M122969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA8 Gene:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and
constitutively expressed members. This protein belongs to the latter group, which are also referred to as
heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct
folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of
membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for HSPA8 Gene:
HSPA8 (heat shock 70kDa protein 8) is a protein-coding gene. Diseases associated with HSPA8 include inner ear disease, and autoimmune inner ear disease. GO annotations related to this gene include unfolded protein binding and ATPase activity, coupled. An important paralog of this gene is HSPA9.

UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of
CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral
part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the
spliceosome assembly as it contacts all other components of the core complex

Gene Wiki entry for HSPA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA8 gene promoter:
         STAT1   Sp1   p300   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA8 promoter sequence
   Search Chromatin IP Primers for HSPA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

HSPA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M122982:  view genomic region     (about GC identifiers)

Start:
122,928,197 bp from pter      End:
122,933,938 bp from pter
Size:
5,742 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142 (See protein sequence)
Recommended Name: Heat shock cognate 71 kDa protein  
Size: 646 amino acids; 70898 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with
PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7. Interacts with
CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated
transcription transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex
comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins
CTNNBL1, CWC15 and HSPA8. Interacts with SV40 VP1. Interacts with TRIM5. Part of a complex composed at least of
ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a
histone H3-specific methyltransferase activity. Interacts with METTL21A
Selected PDB 3D structures from and Proteopedia for HSPA8 (see all 11):
3AGY (3D)        3AGZ (3D)        3ESK (3D)        3FZF (3D)        3FZH (3D)        3FZK (3D)    
Secondary accessions: Q9H3R6
Alternative splicing: 2 isoforms:  P11142-1   P11142-2   

Explore the universe of human proteins at neXtProt for HSPA8: NX_P11142

Explore proteomics data for HSPA8 at MOPED

Post-translational modifications: 

  • Acetylated1
  • ISGylated1
  • Trimethylation at Lys-561 reduces fibrillar SNCA binding1
  • Ubiquitination2 at Lys3, Lys25, Lys56, Lys71, Lys88, Lys108, Lys112, Lys126, Lys128, Lys137,
                                 Lys159, Lys187, Lys188, Lys246, Lys319, Lys325, Lys328, Lys345, Lys348, Lys357 (see all 32)
  • Modification sites at PhosphoSitePlus

  • See HSPA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006588.1  NP_694881.1  

    ENSEMBL proteins: 
     ENSP00000437125   ENSP00000437189   ENSP00000432083   ENSP00000404372   ENSP00000227378  
     ENSP00000433316   ENSP00000433584   ENSP00000435908   ENSP00000435019   ENSP00000432884  
     ENSP00000436762   ENSP00000435154   ENSP00000431641   ENSP00000436183   ENSP00000434415  
     ENSP00000434565   ENSP00000434851  
    Reactome Protein details: P11142

    HSPA8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HSPA8

     
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    antibodies-online peptides for HSPA8

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    antibodies-online antibodies for HSPA8 (166 products) 

    HSPA8 Assay Products:

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    antibodies-online kits for HSPA8 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P11142

    ProtoNet protein and cluster: P11142

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
    Domain: The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the
    peptide-binding domain
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP7C_HUMAN, P11142
    Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of
    CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral
    part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the
    spliceosome assembly as it contacts all other components of the core complex
    Induction: Constitutively synthesized

         Genatlas biochemistry entry for HSPA8:
    heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a
    stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10722728
    GO:0005524ATP binding IEA--
    GO:0023026MHC class II protein complex binding IDA--
    GO:0042623ATPase activity, coupled NAS8530083
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HSPA8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA8:
     Decreased viability of wild-ty  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HSPA8

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA8:
    hsa-mir-149-5p (MIRT045436), hsa-mir-615-3p (MIRT039668), hsa-mir-151a-5p (MIRT038193), hsa-mir-92a-3p (MIRT049282), hsa-mir-16-5p (MIRT051117), hsa-mir-877-5p (MIRT037227), hsa-mir-26a-5p (MIRT050082), hsa-mir-324-3p (MIRT042836), hsa-mir-320a (MIRT044798), hsa-let-7b-5p (MIRT052021), hsa-mir-25-3p (MIRT050343), hsa-mir-10a-5p (MIRT047545), hsa-mir-130b-5p (MIRT038316), hsa-mir-15b-5p (MIRT046453)

    Block miRNA regulation of human, mouse, rat HSPA8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA8 (see all 30):
    hsa-miR-106a hsa-miR-301a hsa-miR-519a hsa-miR-3190 hsa-miR-3692 hsa-miR-1297 hsa-miR-641 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHSPA8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA8

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HSPA8 (NM_006597)
    Sino Biological Human cDNA Clone for HSPA8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA8
    Addgene plasmids for HSPA8 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSP7C_HUMAN, P11142: Cytoplasm. Melanosome. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules
    containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the
    nucleoli, upon heat shock
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus5
    cytosol4
    plasma membrane4
    cytoskeleton2
    endoplasmic reticulum2
    lysosome2
    mitochondrion2
    vacuole2
    endosome1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000974Prp19 complex IDA--
    GO:0005622intracellular NAS8713105
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IEA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with HSPA8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA8 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32
    trans-Golgi Network Vesicle Budding0.89
    4L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    CHL1 interactions0.00
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68


    Find genes that share SuperPaths with HSPA8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HSPA8
        Cellular Transformation by HTLV1

    Selected GeneGo (Thomson Reuters) Pathways for HSPA8 (see all 7)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    Selected BioSystems Pathways for HSPA8 (see all 6)
        MAPK signaling pathway
    Diurnally regulated genes with circadian orthologs
    Parkin-Ubiquitin Proteasomal System pathway
    TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling


    Selected Reactome Pathways for HSPA8 (see all 8)
        Regulation of HSF1-mediated heat shock response
    HSF1-dependent transactivation
    GABA synthesis, release, reuptake and degradation
    Lysosome Vesicle Biogenesis
    Attenuation phase


    Selected Kegg Pathways  (Kegg details for HSPA8) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA8: 
              Autophagy in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA8 (P111421, 2, 3 ENSP000002273784) via UniProtKB, MINT, STRING, and/or I2D (see all 1397)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG1Q999331, 2, 3EBI-351896,EBI-1030678 MINT-7265483 MINT-7265269 MINT-7265281 MINT-7265310 MINT-7265364 MINT-7265296 MINT-7265351 MINT-7265464 MINT-7265324 MINT-7265339 I2D: score=4 
    HSPA1AP081072, 3, ENSP000003648024MINT-6735120 MINT-4050722 I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    ENSG00000215328P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    ENSG00000224501P081072, 3MINT-6735120 MINT-4050722 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006200ATP catabolic process NAS8530083
    GO:0006351transcription, DNA-templated IEA--
    GO:0006397mRNA processing IEA--
    GO:0006457protein folding NAS8530083

    Find genes that share ontologies with HSPA8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HSPA8 (HSP7C)

    2 DrugBank Compounds for HSPA8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol-- --target--10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--10592235

    Selected Novoseek inferred chemical compound relationships for HSPA8 gene (see all 117)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 63.2 7 14579785 (2), 16311509 (1), 15358157 (1), 16173045 (1) (see all 5)
    17-(allylamino)-17-demethoxygeldanamycin 53.9 2 15774780 (1), 17409432 (1)
    geranylgeranylacetone 50.5 3 11119869 (1), 17684364 (1), 14605546 (1)
    atp 50.1 91 10493815 (4), 16141393 (4), 8702658 (4), 7547923 (4) (see all 38)
    radicicol 46.5 2 17409432 (1), 16173045 (1)
    sodium arsenite 46 1 10544156 (1)
    quercetin 42.4 14 9482255 (2), 8347809 (2), 9334813 (2), 19296652 (1) (see all 8)
    adp 36.6 28 1356434 (3), 10493815 (2), 16806043 (2), 9321400 (1) (see all 17)
    delta-12-pgj2 35.7 2 9824682 (2)
    cdcl2 32.1 3 15764298 (1), 11341981 (1), 7593327 (1)



    Find genes that share compounds with HSPA8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA8 gene (2 alternative transcripts): 
    NM_006597.5  NM_153201.3  

    Unigene Cluster for HSPA8:

    Heat shock 70kDa protein 8
    Hs.180414  [show with all ESTs]
    Unigene Representative Sequence: BC042163
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000532636 ENST00000533540 ENST00000534624(uc001pyo.3 uc010rzu.2)
    ENST00000453788(uc001pyp.3) ENST00000532091(uc009zbc.3) ENST00000227378
    ENST00000534319 ENST00000526110 ENST00000524552 ENST00000526686 ENST00000533238
    ENST00000526862 ENST00000527983(uc009zbd.2) ENST00000528292 ENST00000532780(uc010rzv.1)
    ENST00000525463 ENST00000532167 ENST00000525624
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    Additional mRNA sequence: 

    AB034951.1 AB073886.1 AF217511.1 AF352832.1 AK000571.1 AK096100.1 AK129885.1 AK222628.1 
    AK222785.1 AK292067.1 AK300404.1 AK303935.1 AK310467.1 BC007276.1 BC008907.2 BC015699.1 
    BC016179.1 BC016660.1 BC019816.2 BC042163.1 

    Selected DOTS entries (see all 212):

    DT.100741793  DT.100862687  DT.91861874  DT.120705014  DT.100846469  DT.100060526  DT.91769577  DT.100060520 
    DT.97869881  DT.100866889  DT.100637353  DT.120705101  DT.100741754  DT.91808254  DT.100741771  DT.120704813 
    DT.100741714  DT.95198199  DT.100741706  DT.100741806  DT.120705037  DT.100637324  DT.120704685  DT.120704654 

    Selected AceView cDNA sequences (see all 2778):

    BQ224735 AL709996 AA378772 BX475651 BM452246 BU627291 BX497907 BG171692 
    BU159477 BU195105 BP872117 BM474338 CA427882 BM480100 AA374455 AL709827 
    NM_006597 BQ217127 BQ775653 BM811269 BU169610 BM466355 BM796904 BP871132 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                -                                                     -                                                         
    SP2:                    -           -                                                     -                                                         
    SP3:                                -                                                     -           -     -     -     -     -                     
    SP4:                                -                                                                                                               
    SP5:                                                                                      -                 -     -                                 


    ECgene alternative splicing isoforms for HSPA8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSPA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGAGGAA
    HSPA8 Expression
    About this image


    HSPA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
     
     Tooth (Integumentary System)
             Dental Enamel
    HSPA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180414

    UniProtKB/Swiss-Prot: HSP7C_HUMAN, P11142
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA8: 
              Autophagy in human mouse rat
              Cellular Stress Responses in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA8 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa81 , 5 heat shock protein 81, 5 89.53(n)1
    99.85(a)1
      9 (21.55 cM)5
    154811  NM_031165.41  NP_112442.21 
     408009845 
    chicken
    (Gallus gallus)
    Aves HSPA81 heat shock 70kDa protein 8 84.42(n)
    97.99(a)
      395853  NM_205003.2  NP_990334.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA86
    heat shock 70kDa protein 8
    99(a)
    1 ↔ 1
    LGa(3019773-3029849)
    African clawed frog
    (Xenopus laevis)
    Amphibia U55070.12   -- 82.44(n)    U55070.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063228.12   -- 82.75(n)   30675  BC063228.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43
    Hsc70-11
    neurotransmitter secretion chaperone3
    Heat shock protein cognate 11
    86(a)
    (best of 11)3
    71.41(n)1
    82.19(a)1
      88E43
    395421  NM_079339.31  NP_524063.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-11 , 3 HSP-1 heat shock 70kd protein A3
    hsp-11
    86(a)
    (best of 7)3
    74.01(n)1
    86.62(a)1
      IV(17279119-17281340)3
    1785071  NM_070667.41  NP_503068.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSB2(YNL209W)4 Cytoplasmic ATPase that is a ribosome-associated molecular more   --   14(252059-253900) 855512  NP_014190.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G094401 AT3G09440 70.66(n)
    78.03(a)
      820102  NM_001202918.1  NP_001189847.1 
    rice
    (Oryza sativa)
    Liliopsida AK065431.12   -- 76.64(n)    AK065431.1 


    ENSEMBL Gene Tree for HSPA8 (if available)
    TreeFam Gene Tree for HSPA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA8 gene
    HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA142  HSPA22  HSPA1A2  
    Selected SIMAP similar genes for HSPA8 using alignment to 16 protein entries:     HSP7C_HUMAN (see all proteins) (see all similar genes):
    LOC401308    HSP70-1    HSPA2    HSPA1A    LOC401309    HSPA1B
    HSPA6    HSPA1L    HSPA7    HSPA5    HSPA14    HSPA9
    HS24/P52    HS24/p52    HSPA13    HYOU1    HSPA4L    HSPH1

    Find genes that share paralogs with HSPA8           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HSPA8 (see all 30)
    PGOHUM00000257785 PGOHUM00000239629 PGOHUM00000257950 PGOHUM00000257951 PGOHUM00000257952


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA8 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs736105261,2
    C,F--122793468(+) CTTAAC/TTAACC 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1392232631,2
    --122793523(+) CTCAGA/GAAGAA 2 -- ds50010--------
    rs1423134601,2
    --122793544(+) ACAGGA/GCAGTG 2 -- ds50010--------
    rs1505047451,2
    --122793549(+) GCAGTA/GGCTCA 2 -- ds50010--------
    rs1394768331,2
    --122793660(+) TCCAGA/GAAAGC 2 -- ds50010--------
    rs1497440751,2
    C--122793679(+) CTAGGC/TAGGCT 2 -- ds50010--------
    rs1158727411,2
    F--122793795(+) CTCAAA/TGCTCT 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1898027701,2
    --122793857(+) GCCCTC/TGTTAA 2 -- ds50010--------
    rs1822928381,2
    --122793858(+) CCCTTA/GTTAAC 2 -- ds50010--------
    rs1456684181,2
    --122793868(+) CTCAAA/GCTTAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HSPA8 (122928197 - 122933938 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPA8: --
    Human Gene Mutation Database (HGMD): HSPA8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA8
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600816    OMIM disorders: --

    10 diseases for HSPA8:    
    About MalaCards
    inner ear disease    autoimmune inner ear disease    menieres disease    borna disease
    spinocerebellar ataxia type 17    lyme disease    meniere's disease    primary hyperoxaluria
    ischemia    malaria


    Find genes that share disorders with HSPA8           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSPA8 gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 94.4 1714 9563600 (6), 18282334 (6), 18601599 (5), 10397208 (5) (see all 99)
    tumors 44.6 98 16038410 (2), 8276657 (2), 14678977 (2), 12826079 (2) (see all 76)
    neurodegenerative diseases 44.5 3 18975920 (1), 18199697 (1)
    menieres disease 41.9 10 10983953 (2), 9508029 (1), 12170155 (1), 9023247 (1) (see all 8)
    necrosis 36.7 26 9338474 (2), 15507967 (2), 9459115 (1), 16487255 (1) (see all 24)
    ear diseases 36.7 4 11889388 (2), 12768679 (1), 10201752 (1)
    cancer 30.8 31 19802014 (2), 11350684 (2), 15741319 (2), 10705241 (1) (see all 28)
    ischemia 30.4 41 8431764 (4), 8361650 (4), 8360284 (4), 8515271 (4) (see all 20)
    hearing loss sensorineural 27.9 8 7546586 (2), 7872600 (1), 18259075 (1), 17434470 (1) (see all 7)
    cell damage 23.6 6 18336662 (1), 1656141 (1), 16883109 (1), 19232737 (1) (see all 5)

    Genetic Association Database (GAD): HSPA8
    Human Genome Epidemiology (HuGE) Navigator: HSPA8 (16 documents)

    Export disorders for HSPA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA8 gene, integrated from 10 sources (see all 1210):
    (articles sorted by number of sources associating them with HSPA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PubMed id 3037489)1, 2, 3 Dworniczak B.P. and Mirault M.-E. (Nucleic Acids Res. 1987)
    2. Molecular and functional characterization of HSC54, a novel variant of human heat shock cognate protein 70. (PubMed id 11093761)1, 2, 9 Tsukahara F.... Muraki T. (Mol. Pharmacol. 2000)
    3. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PubMed id 8530083)1, 3, 9 Tavaria M....Kola I. (Genomics 1995)
    4. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. (PubMed id 9305631)1, 2, 9 Takayama S.... Reed J.C. (EMBO J. 1997)
    5. Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk. (PubMed id 14991745)1, 4, 9 Rusin M....Krawczyk Z. (Mol. Carcinog. 2004)
    6. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Molecular architecture of the human Prp19/CDC5L complex. (PubMed id 20176811)1, 2 Grote M.... Luhrmann R. (Mol. Cell. Biol. 2010)
    9. Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population. (PubMed id 20300519)1, 4 He M....Wu T. (PLoS ONE 2010)
    10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3312 HGNC: 5241 AceView: HSPA8 Ensembl:ENSG00000109971 euGenes: HUgn3312
    ECgene: HSPA8 Kegg: 3312 H-InvDB: HSPA8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HSPA8 gene:
    Search GeneIP for patents involving HSPA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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