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Aliases for HSPA8 Gene

Aliases for HSPA8 Gene

  • Heat Shock Protein Family A (Hsp70) Member 8 2 3 5
  • Lipopolysaccharide-Associated Protein 1 3 4
  • Heat Shock 70kDa Protein 8 2 3
  • LPS-Associated Protein 1 3 4
  • HSPA10 3 4
  • HSC70 3 4
  • HSP73 3 4
  • LAP-1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 72p 3
  • N-Myristoyltransferase Inhibitor Protein 71 3
  • Constitutive Heat Shock Protein 70 3
  • Epididymis Luminal Protein 33 3
  • Heat Shock Cognate Protein 54 3
  • Heat Shock 70 KDa Protein 8 4
  • Heat Shock 70kd Protein 10 3
  • Heat Shock 70kD Protein 8 2
  • HEL-S-72p 3
  • HEL-33 3
  • HSC54 3
  • HSC71 3
  • HSP71 3
  • NIP71 3
  • LAP1 3

External Ids for HSPA8 Gene

Previous HGNC Symbols for HSPA8 Gene

  • HSPA10

Previous GeneCards Identifiers for HSPA8 Gene

  • GC11M124929
  • GC11M124441
  • GC11M122962
  • GC11M122465
  • GC11M122436
  • GC11M122437
  • GC11M122439
  • GC11M122444
  • GC11M122450
  • GC11M122452
  • GC11M122454
  • GC11M122456
  • GC11M122458
  • GC11M122460
  • GC11M122463
  • GC11M122468
  • GC11M122934
  • GC11M122938
  • GC11M118870
  • GC11M122942
  • GC11M122947
  • GC11M122948
  • GC11M122952
  • GC11M122959
  • GC11M122969
  • GC11M122982

Summaries for HSPA8 Gene

Entrez Gene Summary for HSPA8 Gene

  • This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HSPA8 Gene

HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) is a Protein Coding gene. Diseases associated with HSPA8 include auditory system disease and brain ischemia. Among its related pathways are Allograft rejection and Endocytosis. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA8 Gene

  • Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.

Gene Wiki entry for HSPA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA8 Gene

Genomics for HSPA8 Gene

Regulatory Elements for HSPA8 Gene

Enhancers for HSPA8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPA8 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA8 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA8 Gene

Chromosome:
11
Start:
123,057,489 bp from pter
End:
123,063,230 bp from pter
Size:
5,742 bases
Orientation:
Minus strand

Genomic View for HSPA8 Gene

Genes around HSPA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA8 Gene

Proteins for HSPA8 Gene

  • Protein details for HSPA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11142-HSP7C_HUMAN
    Recommended name:
    Heat shock cognate 71 kDa protein
    Protein Accession:
    P11142
    Secondary Accessions:
    • Q9H3R6

    Protein attributes for HSPA8 Gene

    Size:
    646 amino acids
    Molecular mass:
    70898 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with PACRG. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 and BAG1. Interacts with DNAJC7 and DNAJB14 (via J domain). Interacts (via C-terminus) with the E3 ligase CHIP forming a 210 kDa complex of one CHIP and two HSPA8 molecules. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts with SV40 VP1. Interacts with TRIM5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with METTL21A. Following LPS binding, may form a complex with CXCR4, GDF5 and HSP90AA1. Interacts with PARK2. Interacts with FOXP3. Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with MLLT11 (PubMed:24880125).

    Three dimensional structures from OCA and Proteopedia for HSPA8 Gene

    Alternative splice isoforms for HSPA8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA8 Gene

Proteomics data for HSPA8 Gene at MOPED

Post-translational modifications for HSPA8 Gene

  • Acetylated.
  • ISGylated.
  • Trimethylation at Lys-561 reduces fibrillar SNCA binding.
  • Ubiquitination at Lys 3, Lys 25, Lys 56, Lys 71, Lys 88, Lys 112, Lys 126, Lys 128, Lys 137, Lys 159, Lys 188, Lys 325, Lys 361, Lys 423, Lys 458, Lys 512, Lys 524, Lys 539, Lys 573, Lys 583, and Lys 597
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HSPA8 Gene

Domains & Families for HSPA8 Gene

Gene Families for HSPA8 Gene

Protein Domains for HSPA8 Gene

Suggested Antigen Peptide Sequences for HSPA8 Gene

Graphical View of Domain Structure for InterPro Entry

P11142

UniProtKB/Swiss-Prot:

HSP7C_HUMAN :
  • The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA8: view

Function for HSPA8 Gene

Molecular function for HSPA8 Gene

GENATLAS Biochemistry:
heat shock 73kDa,protein A8 (HSP70 family),structurally related to aconitase,mediating the suppression of a stress-activated protein kinase JNK (SERK1),increasing cell survival by inhibition of the apoptotic program
UniProtKB/Swiss-Prot Function:
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.
UniProtKB/Swiss-Prot Induction:
Constitutively synthesized.

Gene Ontology (GO) - Molecular Function for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding IEA --
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with HSPA8: view
genes like me logo Genes that share phenotypes with HSPA8: view

Animal Model Products

miRNA for HSPA8 Gene

miRTarBase miRNAs that target HSPA8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA8 Gene

Localization for HSPA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA8 Gene

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA8 Gene COMPARTMENTS Subcellular localization image for HSPA8 gene
Compartment Confidence
cytosol 5
extracellular 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
mitochondrion 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS 26212789
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005730 nucleolus IEA --
GO:0005765 lysosomal membrane ISS --
genes like me logo Genes that share ontologies with HSPA8: view

Pathways & Interactions for HSPA8 Gene

genes like me logo Genes that share pathways with HSPA8: view

Gene Ontology (GO) - Biological Process for HSPA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006622 protein targeting to lysosome TAS 26212789
GO:0007268 synaptic transmission TAS --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with HSPA8: view

No data available for SIGNOR curated interactions for HSPA8 Gene

Drugs & Compounds for HSPA8 Gene

(59) Drugs for HSPA8 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Experimental Pharma Target 0

(59) Additional Compounds for HSPA8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA8: view

Transcripts for HSPA8 Gene

Unigene Clusters for HSPA8 Gene

Heat shock 70kDa protein 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP2: - - -
SP3: - - - - - - -
SP4: -
SP5: - - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for HSPA8 Gene

GeneLoc Exon Structure for
HSPA8
ECgene alternative splicing isoforms for
HSPA8

Expression for HSPA8 Gene

mRNA expression in normal human tissues for HSPA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA8 Gene

This gene is overexpressed in Lymph node (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA8 Gene



SOURCE GeneReport for Unigene cluster for HSPA8 Gene Hs.180414

mRNA Expression by UniProt/SwissProt for HSPA8 Gene

P11142-HSP7C_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with HSPA8: view

Protein tissue co-expression partners for HSPA8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HSPA8 Gene

Orthologs for HSPA8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA8 35
  • 92.12 (n)
  • 99.84 (a)
HSPA8 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA8 35
  • 91.07 (n)
  • 100 (a)
HSPA8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa8 35
  • 89.53 (n)
  • 99.85 (a)
Hspa8 16
Hspa8 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA8 35
  • 99.33 (n)
  • 100 (a)
HSPA8 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa8 35
  • 89.78 (n)
  • 99.85 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves HSPA8 35
  • 84.42 (n)
  • 97.99 (a)
HSPA8 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA8 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa8 35
  • 82.3 (n)
  • 96.9 (a)
Str.5671 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hspa8 35
  • 82.54 (n)
  • 95.76 (a)
hspa8 36
  • 95 (a)
OneToMany
HSPA8 (1 of 2) 36
  • 93 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7182 37
  • 25 (a)
Hsc70-1 37
  • 82 (a)
Hsc70-2 37
  • 73 (a)
Hsc70-3 37
  • 64 (a)
Hsc70-4 37
  • 86 (a)
Hsp68 37
  • 71 (a)
Hsp70Aa 37
  • 76 (a)
Hsp70Ab 37
  • 75 (a)
Hsp70Ba 37
  • 76 (a)
Hsp70Bb 37
  • 76 (a)
Hsp70Bc 37
  • 76 (a)
Hsc70-1 35
  • 71.41 (n)
  • 82.19 (a)
Hsc70-1 36
  • 81 (a)
ManyToMany
Hsc70-4 36
  • 85 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004944 35
  • 72.33 (n)
  • 86.76 (a)
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 69 (a)
F44E5.5 37
  • 69 (a)
hsp-1 37
  • 86 (a)
hsp-2 37
  • 75 (a)
hsp-3 37
  • 63 (a)
hsp-4 37
  • 63 (a)
hsp-70 37
  • 68 (a)
hsp-1 35
  • 74.01 (n)
  • 86.62 (a)
hsp-1 36
  • 86 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 76 (a)
OneToMany
SSB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09440 35
  • 70.66 (n)
  • 78.03 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2748 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 86 (a)
ManyToMany
CSA.971 36
  • 79 (a)
ManyToMany
Species with no ortholog for HSPA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA8 Gene

ENSEMBL:
Gene Tree for HSPA8 (if available)
TreeFam:
Gene Tree for HSPA8 (if available)

Paralogs for HSPA8 Gene

Paralogs for HSPA8 Gene

genes like me logo Genes that share paralogs with HSPA8: view

Variants for HSPA8 Gene

Sequence variations from dbSNP and Humsavar for HSPA8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_049619 -
VAR_049620 -
rs7948948 -- 123,057,467(+) GGGAG(A/G)TTATT downstream-variant-500B
rs7949127 -- 123,057,408(+) GGAAG(A/G)AGAAA downstream-variant-500B
rs7949220 -- 123,057,418(+) AGTAA(G/T)AGTCA downstream-variant-500B

Variation tolerance for HSPA8 Gene

Residual Variation Intolerance Score: 4.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA8 Gene

HapMap Linkage Disequilibrium report
HSPA8
Human Gene Mutation Database (HGMD)
HSPA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA8 Gene

Disorders for HSPA8 Gene

MalaCards: The human disease database

(6) MalaCards diseases for HSPA8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
auditory system disease
  • destruction - ear drum
brain ischemia
dowling-degos disease
  • reticulate acropigmentation of kitamura
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
leber congenital amaurosis
  • lca
- elite association - COSMIC cancer census association via MalaCards
Search HSPA8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA8

Genetic Association Database (GAD)
HSPA8
Human Genome Epidemiology (HuGE) Navigator
HSPA8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA8
genes like me logo Genes that share disorders with HSPA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA8 Gene

Publications for HSPA8 Gene

  1. Structure and expression of a human gene coding for a 71 kd heat shock 'cognate' protein. (PMID: 3037489) Dworniczak B.P. … Mirault M.-E. (Nucleic Acids Res. 1987) 2 3 4 67
  2. Localization of the gene encoding the human heat shock cognate protein, HSP73, to chromosome 11. (PMID: 8530083) Tavaria M. … Kola I. (Genomics 1995) 2 3 23
  3. Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells. (PMID: 19802014) NirdAc P. … Garcia M. (Oncogene 2010) 3 23
  4. Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts. (PMID: 19321452) Imamura Y. … Wang P.L. (J. Biol. Chem. 2009) 3 23
  5. Two motifs within the tau microtubule-binding domain mediate its association with the hsc70 molecular chaperone. (PMID: 18500754) Sarkar M. … Lee G. (J. Neurosci. Res. 2008) 3 23

Products for HSPA8 Gene

Sources for HSPA8 Gene

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