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heat shock 70kDa protein 7 (HSP70B)(Previous name: heat shock 70kD protein 7 (HSP70B) )
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Aliases
for HSPA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Heat Shock 70kDa Protein 7 (HSP70B)1 2 | | HSP70B2 3 | | Heat Shock 70kD Protein 7 (HSP70B)1 | | Heat Shock 70 KDa Protein B3 |
| External Ids: | HGNC: 52401 | Entrez Gene: 33112 | Ensembl: ENSG000002252177 | OMIM: 1405565 | UniProtKB: P487413 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n406626 | |
Export aliases for HSPA7 gene to outside databasesPrevious GC identifers: GC01U990091 GC01P158763 GC01P158307 GC01P159842 GC01P159762 GC01P161494
Summaries
for HSPA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HSPA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSPA7 gene promoter:
p53 AML1a NRSF form 1 Hand1 STAT3 NRSF form 2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSPA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3HSPA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P161575: view genomic region
(about GC identifiers)
Start:
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161,575,849 bp from pter |
End:
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161,578,341 bp from pter |
Size:
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2,493 bases |
Orientation:
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plus strand |
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Proteins
for HSPA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSP77_HUMAN, P48741 (See
protein sequence)Recommended Name: Putative heat shock 70 kDa protein 7 Size: 367 amino acids; 40244 Da
Caution: Could be the product of a pseudogene
Secondary accessions: P19790Explore the universe of human proteins at neXtProt for HSPA7: NX_P48741
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P48741
HSPA7 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008180 | colocalizes with signalosome |
IDA | 18850735 |
HSPA7 for ontologies About GeneDecksing
HSPA7 Antibody Products:
Assay Products for HSPA7: |
Protein
Domains /
Families
for HSPA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSPA7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P48741ProtoNet protein and cluster: P48741 UniProtKB/Swiss-Prot: HSP77_HUMAN, P48741Similarity: Belongs to the heat shock protein 70 family |
Function
for HSPA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for HSPA7:heat shock 70kDa protein A7,structurally related to aconitase
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
NAS | -- |
HSPA7 for ontologies About GeneDecksing
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Pathways & Interactions
for HSPA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | | | 2 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | | | 3 | Proteolysis Putative ubiquitin pathway | | | 4 | Regulation of degradation of wt-CFTR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  EMD Millipore Pathways for HSPA7
5/6  GeneGo (Thomson Reuters) Pathways for HSPA7 (see all 6)
HSPA7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPA7
5/8 Interacting proteins for HSPA7 (P487413) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006986 | response to unfolded protein |
NAS | -- |
HSPA7 for ontologies About GeneDecksing
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Drugs & Compounds
for HSPA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSPA7
Search CenterWatch for drugs/clinical trials and news about HSPA7
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Transcripts
for HSPA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for HSPA7: Heat shock 70kDa protein 7 (HSP70B) Hs.662180 [show with all ESTs]Unigene Representative Sequence: NR_0241511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000445535(uc010pkp.1)
Additional cDNA sequence: NR_024151.1 5 DOTS entries: DT.121462566 DT.453313 DT.100819773 DT.121462597 DT.100702473
GeneLoc Exon Structure
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Expression
for HSPA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSPA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HSPA7 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.662180
SABiosciences Custom PCR Arrays for HSPA7
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSPA7 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA7 |
Orthologs
for HSPA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for HSPA7 (if available)
TreeFam Gene Tree for HSPA7 (if available) |
Paralogs
for HSPA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HSPA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSPA7 (161575849 - 161578341 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for HSPA7
15/18 CNVs (see all 18): 6791 60899 48149 22935 3316 43697 58342 65090 38950 4258 48148 9375 2329 65089 31666 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HSPA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSPA7 for disorders About GeneDecksing
OMIM gene information: 140556
OMIM disorders: --
2  diseases for HSPA7: About MalaCardschoroiditis neuronitis
Export disorders for HSPA7 gene to outside databases
|
Publications
for HSPA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSPA7 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with HSPA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional. (PubMed id 11072087)1, 3, 9 Parsian A.J....Hunt C.R. (2000)
- The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PubMed id 1346391)1, 3 Leung T.K.C.... Lim L. (1992)
- Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. (PubMed id 3927293)1, 2 Voellmy R.... Rungger D. (1985)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy. (PubMed id 18584345)1 Siddiqui F....Ullrich R.L. (2008)
- Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1 Fang L.... Huang L. (2008)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (2008)
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External Searches for HSPA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HSPA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSPA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSPA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSPA7 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HSPA7 gene:
Search GeneIP for patents involving HSPA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSPA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPA7 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA7 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA7 |
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 |  |  |  | |
| | | | Search Tocris compounds for HSPA7 |
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 | | | HSPA7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA7 |
|  |  |  | | | | Search ThermoFisher Antibodies for HSPA7 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSPA7 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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