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Aliases for HSPA7 Gene

Aliases for HSPA7 Gene

  • Heat Shock Protein Family A (Hsp70) Member 7 2 3 5
  • Heat Shock 70kDa Protein 7 (HSP70B) 2 3
  • Heat Shock 70kD Protein 7 (HSP70B) 2 3
  • HSP70B 3 4
  • Heat Shock 70 KDa Protein B 4

External Ids for HSPA7 Gene

Previous GeneCards Identifiers for HSPA7 Gene

  • GC01U990091
  • GC01P158763
  • GC01P158307
  • GC01P159842
  • GC01P159762
  • GC01P161494

Summaries for HSPA7 Gene

GeneCards Summary for HSPA7 Gene

HSPA7 (Heat Shock Protein Family A (Hsp70) Member 7) is a Pseudogene. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Proteolysis_Putative ubiquitin pathway.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA7 Gene

Genomics for HSPA7 Gene

Regulatory Elements for HSPA7 Gene

Enhancers for HSPA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161544 1.2 Ensembl ENCODE dbSUPER 9.9 -58.5 -58459 6.4 KLF1 PKNOX1 CEBPB MAFG CEBPG ZBTB40 JUND PRDM6 ZNF316 FOXK2 FCGR2C FCGR2A DUSP12 FCRLA FCRLB HSPA7 FCGR2B RPS23P10 FCGR3B FCGR3A
GH01G161611 2 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +6.2 6242 2.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 KLF13 FCGR2B ATF6 FCGR2C FCGR3B DUSP12 HSPA6 HSPA7 FCRLB FCGR3A TRL-CAA6-1
GH01G161539 1.7 Ensembl ENCODE dbSUPER 6 -64.3 -64264 4.8 CREB3L1 FEZF1 YY1 SLC30A9 ZNF263 SP3 TBX21 MEF2D ZNF610 GLIS1 FCGR2C DUSP12 FCGR2A FCRLB ATF6 RPS23P10 HSPA7 FCGR3B TRN-GTT1-1 FCGR3A
GH01G161560 1.6 Ensembl ENCODE dbSUPER 6.2 -44.1 -44059 2.8 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 FOS FCGR2C ATF6 DUSP12 FCRLB FCGR2A FCRLA FCGR2B HSPA7 RPS23P10 ENSG00000224515
GH01G161705 1.3 Ensembl ENCODE 7 +101.1 101087 3.2 PKNOX1 FOXA2 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 CBX5 FOS FCRLA FCRLB FCGR2B HSPA7 GC01M161708
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA7 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014715 141 1201 ZBTB33

Genomic Location for HSPA7 Gene

Chromosome:
1
Start:
161,606,059 bp from pter
End:
161,608,551 bp from pter
Size:
2,493 bases
Orientation:
Plus strand

Genomic View for HSPA7 Gene

Genes around HSPA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA7 Gene

Proteins for HSPA7 Gene

  • Protein details for HSPA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48741-HSP77_HUMAN
    Recommended name:
    Putative heat shock 70 kDa protein 7
    Protein Accession:
    P48741
    Secondary Accessions:
    • P19790

    Protein attributes for HSPA7 Gene

    Size:
    367 amino acids
    Molecular mass:
    40244 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPA7 Gene

Post-translational modifications for HSPA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSPA7 Gene

Domains & Families for HSPA7 Gene

Gene Families for HSPA7 Gene

Protein Domains for HSPA7 Gene

Suggested Antigen Peptide Sequences for HSPA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48741

UniProtKB/Swiss-Prot:

HSP77_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA7: view

Function for HSPA7 Gene

Molecular function for HSPA7 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A7,structurally related to aconitase

Gene Ontology (GO) - Molecular Function for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSPA7 Gene

Localization for HSPA7 Gene

Gene Ontology (GO) - Cellular Components for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0070062 extracellular exosome IDA 23533145
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HSPA7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for HSPA7 Gene

Pathways & Interactions for HSPA7 Gene

genes like me logo Genes that share pathways with HSPA7: view

Interacting Proteins for HSPA7 Gene

Gene Ontology (GO) - Biological Process for HSPA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSPA7: view

No data available for SIGNOR curated interactions for HSPA7 Gene

Drugs & Compounds for HSPA7 Gene

No Compound Related Data Available

Transcripts for HSPA7 Gene

mRNA/cDNA for HSPA7 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA7 Gene

Heat shock 70kDa protein 7 (HSP70B):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA7 Gene

No ASD Table

Relevant External Links for HSPA7 Gene

GeneLoc Exon Structure for
HSPA7
ECgene alternative splicing isoforms for
HSPA7

Expression for HSPA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA7 Gene

mRNA differential expression in normal tissues according to GTEx for HSPA7 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for HSPA7 Gene

This gene is overexpressed in Lavage (51.3) and Urine (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSPA7 Gene



Protein tissue co-expression partners for HSPA7 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA7 Gene:

HSPA7

SOURCE GeneReport for Unigene cluster for HSPA7 Gene:

Hs.662180
genes like me logo Genes that share expression patterns with HSPA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA7 Gene

Orthologs for HSPA7 Gene

Evolution for HSPA7 Gene

ENSEMBL:
Gene Tree for HSPA7 (if available)
TreeFam:
Gene Tree for HSPA7 (if available)

No data available for Orthologs for HSPA7 Gene

Paralogs for HSPA7 Gene

(18) SIMAP similar genes for HSPA7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA7: view

No data available for Paralogs for HSPA7 Gene

Variants for HSPA7 Gene

Sequence variations from dbSNP and Humsavar for HSPA7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002611617 -- 161,605,371(+) TGGAA(A/C)GTGAC upstream-variant-2KB
rs1002877918 -- 161,608,268(+) TGGGC(A/C)TTCTA nc-transcript-variant
rs1003275433 -- 161,607,935(+) TTCCA(C/T)GTGAA nc-transcript-variant
rs1004162639 -- 161,604,785(+) CAGCT(A/G)TTGCA upstream-variant-2KB
rs1004450411 -- 161,605,085(+) CCTTT(A/G)GGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPA7 Gene

Variant ID Type Subtype PubMed ID
dgv22n16 CNV deletion 17901297
dgv23n16 CNV insertion 17901297
dgv24n16 CNV insertion 17901297
dgv38e201 CNV deletion 23290073
dgv447n100 CNV gain 25217958
dgv448n100 CNV loss 25217958
dgv449n100 CNV gain+loss 25217958
dgv450n100 CNV gain 25217958
dgv451n100 CNV loss 25217958
dgv4n68 CNV gain+loss 17160897
dgv5e203 CNV gain+loss 21179565
dgv605n54 CNV loss 21841781
dgv606n54 CNV loss 21841781
dgv607n54 CNV loss 21841781
dgv75e199 CNV deletion 23128226
dgv85n67 CNV loss 20364138
dgv8e55 CNV gain 17911159
esv2507888 CNV deletion 19546169
esv2718873 CNV deletion 23290073
esv2758972 CNV gain+loss 17122850
esv28122 CNV gain+loss 19812545
esv2997123 CNV deletion 24192839
esv3325 CNV loss 18987735
esv33393 CNV gain+loss 17666407
esv3541689 CNV deletion 23714750
esv3584532 CNV gain 24956385
esv3587731 CNV loss 21293372
esv3587732 CNV loss 21293372
esv3587733 CNV gain 21293372
esv3890693 CNV loss 25118596
esv5752 CNV loss 19470904
esv990743 CNV loss 20482838
esv997087 CNV loss 20482838
nsv1112219 CNV deletion 24896259
nsv1115373 CNV duplication 24896259
nsv1161862 CNV duplication 26073780
nsv428257 CNV loss 18775914
nsv442209 CNV gain 18776908
nsv464173 CNV gain 19166990
nsv509546 CNV insertion 20534489
nsv514915 CNV gain 21397061
nsv517640 CNV gain+loss 19592680
nsv519779 CNV loss 19592680
nsv548066 CNV gain 21841781
nsv548072 CNV loss 21841781
nsv818489 CNV gain 17921354
nsv818500 CNV gain 17921354
nsv819523 CNV loss 19587683
nsv820341 CNV duplication 20802225
nsv821621 CNV loss 15273396
nsv825176 CNV gain 20364138
nsv825242 CNV loss 20364138
nsv825254 CNV gain 20364138
nsv8502 CNV loss 18304495
nsv946468 CNV duplication 23825009

Relevant External Links for HSPA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSPA7 Gene

Disorders for HSPA7 Gene

Relevant External Links for HSPA7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA7

No disorders were found for HSPA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA7 Gene

Publications for HSPA7 Gene

  1. The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional. (PMID: 11072087) Parsian A.J. … Hunt C.R. (Biochim. Biophys. Acta 2000) 2 3 22 64
  2. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PMID: 1346391) Leung T.K.C. … Lim L. (Genomics 1992) 2 3 64
  3. Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. (PMID: 3927293) Voellmy R. … Rungger D. (Proc. Natl. Acad. Sci. U.S.A. 1985) 3 4 64
  4. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for HSPA7 Gene

Sources for HSPA7 Gene

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