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Aliases for HSPA6 Gene

Aliases for HSPA6 Gene

  • Heat Shock 70kDa Protein 6 (HSP70B') 2
  • Heat Shock 70kDa Protein 6 (HSP70B) 2 3
  • Heat Shock 70kD Protein 6 (HSP70B) 2
  • Heat Shock 70 KDa Protein B 4
  • HSP70B 4

External Ids for HSPA6 Gene

Previous GeneCards Identifiers for HSPA6 Gene

  • GC01P159211
  • GC01P157225
  • GC01P158271
  • GC01P158764
  • GC01P158765
  • GC01P158308
  • GC01P159760
  • GC01P161495
  • GC01P132819

Summaries for HSPA6 Gene

GeneCards Summary for HSPA6 Gene

HSPA6 (Heat Shock 70kDa Protein 6 (HSP70B')) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Endocytosis. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA6 Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).

Gene Wiki entry for HSPA6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA6 Gene

Genomics for HSPA6 Gene

Regulatory Elements for HSPA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA6 Gene

Start:
161,524,246 bp from pter
End:
161,526,910 bp from pter
Size:
2,665 bases
Orientation:
Plus strand

Genomic View for HSPA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA6 Gene

Proteins for HSPA6 Gene

  • Protein details for HSPA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17066-HSP76_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 6
    Protein Accession:
    P17066
    Secondary Accessions:
    • Q1HBA8
    • Q8IYK7
    • Q9BT95

    Protein attributes for HSPA6 Gene

    Size:
    643 amino acids
    Molecular mass:
    71028 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HSPA6 Gene

neXtProt entry for HSPA6 Gene

Proteomics data for HSPA6 Gene at MOPED

Post-translational modifications for HSPA6 Gene

  • Ubiquitination at Lys321, Lys359, Lys453, Lys499, Lys502, and Lys509
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA6 Gene

Domains for HSPA6 Gene

Gene Families for HSPA6 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA6 Gene

Suggested Antigen Peptide Sequences for HSPA6 Gene

Graphical View of Domain Structure for InterPro Entry

P17066

UniProtKB/Swiss-Prot:

HSP76_HUMAN :
  • P17066
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA6: view

Function for HSPA6 Gene

Molecular function for HSPA6 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A6,structurally related to aconitase
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).
UniProtKB/Swiss-Prot Induction:
Only at higher temperatures, and no basal expression

Gene Ontology (GO) - Molecular Function for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0019899 enzyme binding IPI 23921388
GO:0031072 heat shock protein binding IPI 21231916
GO:0042623 ATPase activity, coupled IDA 21231916
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with HSPA6: view

Phenotypes for HSPA6 Gene

genes like me logo Genes that share phenotypes with HSPA6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSPA6 Gene

Localization for HSPA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA6 Gene COMPARTMENTS Subcellular localization image for HSPA6 gene
Compartment Confidence
cytosol 3
golgi apparatus 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24061851
GO:0005814 centriole IDA 24061851
GO:0005829 cytosol IDA 21231916
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with HSPA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA6 Gene

Pathways for HSPA6 Gene

genes like me logo Genes that share pathways with HSPA6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Gene Ontology (GO) - Biological Process for HSPA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006200 obsolete ATP catabolic process --
GO:0006986 response to unfolded protein TAS 2327978
GO:0034605 cellular response to heat IMP 21597468
GO:0042026 protein refolding IDA 21231916
genes like me logo Genes that share ontologies with HSPA6: view

Compounds for HSPA6 Gene

(2) Novoseek inferred chemical compound relationships for HSPA6 Gene

Compound -log(P) Hits PubMed IDs
cdcl2 60 6
atp 22.7 6
genes like me logo Genes that share compounds with HSPA6: view

Transcripts for HSPA6 Gene

mRNA/cDNA for HSPA6 Gene

(7) Additional mRNA sequences :
(509) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA6 Gene

Heat shock 70kDa protein 6 (HSP70B):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA6 Gene

No ASD Table

Relevant External Links for HSPA6 Gene

GeneLoc Exon Structure for
HSPA6
ECgene alternative splicing isoforms for
HSPA6

Expression for HSPA6 Gene

mRNA expression in normal human tissues for HSPA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA6 Gene

This gene is overexpressed in Whole Blood (26.5).

Protein differential expression in normal tissues for HSPA6 Gene

This gene is overexpressed in Saliva (24.1), Adipocyte (24.0), and Brain (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA6 Gene

SOURCE GeneReport for Unigene cluster for HSPA6 Gene Hs.654614

genes like me logo Genes that share expressions with HSPA6: view

Expression partners for HSPA6 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HSPA6 Gene

Orthologs for HSPA6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA6 35
  • 90.41 (n)
  • 94.25 (a)
HSPA6 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA6 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 76 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mcm5 36
  • 79 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7182 37
  • 26 (a)
Hsc70-1 37
  • 77 (a)
Hsc70-2 37
  • 71 (a)
Hsc70-3 37
  • 61 (a)
Hsc70-4 37
  • 79 (a)
Hsp68 37
  • 69 (a)
Hsp70Aa 37
  • 72 (a)
Hsp70Ab 37
  • 72 (a)
Hsp70Ba 37
  • 73 (a)
Hsp70Bb 37
  • 73 (a)
Hsp70Bc 37
  • 73 (a)
Hsc70-1 36
  • 76 (a)
ManyToMany
Hsc70-4 36
  • 77 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 68 (a)
F44E5.5 37
  • 68 (a)
hsp-1 37
  • 80 (a)
hsp-2 37
  • 74 (a)
hsp-3 37
  • 60 (a)
hsp-4 37
  • 60 (a)
hsp-70 37
  • 66 (a)
hsp-1 36
  • 78 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 71 (a)
OneToMany
SSZ1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 75 (a)
ManyToMany
CSA.971 36
  • 72 (a)
ManyToMany
Species with no ortholog for HSPA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA6 Gene

ENSEMBL:
Gene Tree for HSPA6 (if available)
TreeFam:
Gene Tree for HSPA6 (if available)

Paralogs for HSPA6 Gene

Paralogs for HSPA6 Gene

Selected SIMAP similar genes for HSPA6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HSPA6 Gene

genes like me logo Genes that share paralogs with HSPA6: view

Variants for HSPA6 Gene

Sequence variations from dbSNP and Humsavar for HSPA6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs368844 - 161,526,388(-) CTTCC(C/T)GACAC missense, reference
rs388218 - 161,526,049(-) TGCCA(A/C)TGAGT reference, missense
rs404508 -- 161,526,095(-) TCAAA(A/C/G)GTCAC synonymous-codon, reference
rs417707 - 161,525,664(-) GACGA(A/C)GTCAT reference, missense
rs425949 -- 161,524,559(-) TCTGC(A/C)GCCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPA6 Gene

Variant ID Type Subtype PubMed ID
dgv133e1 CNV Complex 17122850
dgv4n68 CNV Gain+Loss 17160897
dgv134e1 CNV Complex 17122850
nsv428257 CNV Loss 18775914
esv28122 CNV Gain+Loss 19812545
dgv8e55 CNV Gain 17911159
dgv135e1 CNV Complex 17122850
dgv136e1 CNV Complex 17122850
nsv8502 CNV Loss 18304495
esv33393 CNV Gain+Loss 17666407
dgv17n21 CNV Loss 19592680
nsv519779 CNV Loss 19592680
nsv464173 CNV Gain 19166990
nsv825176 CNV Gain 20364138
nsv820341 CNV Duplication 20802225
nsv872494 CNV Gain 21882294
dgv397n71 CNV Gain 21882294
dgv398n71 CNV Gain 21882294
esv2718873 CNV Deletion 23290073
esv997087 CNV Loss 20482838
dgv22n16 CNV Deletion 17901297
dgv74e199 CNV Deletion 23128226
dgv85n67 CNV Loss 20364138
nsv819523 CNV Loss 19587683
nsv818489 CNV Gain 17921354
nsv517640 CNV Gain+Loss 19592680

Relevant External Links for HSPA6 Gene

HapMap Linkage Disequilibrium report
HSPA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA6 Gene

Disorders for HSPA6 Gene

(1) Novoseek inferred disease relationships for HSPA6 Gene

Disease -log(P) Hits PubMed IDs
shock 55.3 4

Relevant External Links for HSPA6

Genetic Association Database (GAD)
HSPA6
Human Genome Epidemiology (HuGE) Navigator
HSPA6
genes like me logo Genes that share disorders with HSPA6: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for HSPA6 Gene

Publications for HSPA6 Gene

  1. The human heat-shock protein family. Expression of a novel heat- inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. (PMID: 2327978) Leung T.K.C. … Lim L. (Biochem. J. 1990) 3 4 23
  2. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PMID: 1346391) Leung T.K.C. … Lim L. (Genomics 1992) 2 3 4
  3. Cis-acting elements involved in the regulated expression of a human HSP70 gene. (PMID: 3184191) Schiller P. … Voellmy R. (J. Mol. Biol. 1988) 3 4
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 48

Products for HSPA6 Gene

  • Addgene plasmids for HSPA6

Sources for HSPA6 Gene

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