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HSPA6 Gene

protein-coding   GIFtS: 67
GCID: GC01P161495

Heat Shock 70kDa Protein 6 (HSP70B')

(Previous name: heat shock 70kD protein 6 (HSP70B'))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 6 (HSP70B')1 2
Heat Shock 70kD Protein 6 (HSP70B')1 2
Heat Shock 70 KDa Protein B'2 3
Heat Shock 70 KDa Protein 62
HSP70B'3

External Ids:    HGNC: 52391   Entrez Gene: 33102   Ensembl: ENSG000001731107   OMIM: 1405555   UniProtKB: P170663   

Export aliases for HSPA6 gene to outside databases

Previous GC identifers: GC01P159211 GC01P157225 GC01P158271 GC01P158764 GC01P158765 GC01P158308 GC01P159760 GC01P132819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSPA6 Gene:
HSPA6 (heat shock 70kDa protein 6 (HSP70B')) is a protein-coding gene. Diseases associated with HSPA6 include legionellosis, and toxoplasmosis. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage (By similarity)

Gene Wiki entry for HSPA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA6 gene promoter:
         p53   AML1a   NRSF form 1   FOXD1   CUTL1   NRSF form 2   E47   STAT3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA6 promoter sequence
   Search Chromatin IP Primers for HSPA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

HSPA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161495:  view genomic region     (about GC identifiers)

Start:
161,494,036 bp from pter      End:
161,496,687 bp from pter
Size:
2,652 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 6  
Size: 643 amino acids; 71028 Da
1 PDB 3D structure from and Proteopedia for HSPA6:
3FE1 (3D)    
Secondary accessions: Q1HBA8 Q8IYK7 Q9BT95

Explore the universe of human proteins at neXtProt for HSPA6: NX_P17066

Explore proteomics data for HSPA6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys321, Lys359, Lys453, Lys499, Lys502, Lys509
  • Modification sites at PhosphoSitePlus

  • See HSPA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002146.2  
    ENSEMBL proteins: 
     ENSP00000310219  

    HSPA6 Human Recombinant Protein Products:

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    Novus Biologicals HSPA6 Proteins
    Novus Biologicals HSPA6 Lysate
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPA6
    Cloud-Clone Corp. Proteins for HSPA6

    HSPA6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibody for HSPA6
    LSBio Antibodies in human, mouse, rat for HSPA6

    HSPA6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HSPA6
    Cloud-Clone Corp. CLIAs for HSPA6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P17066

    ProtoNet protein and cluster: P17066

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066
    Similarity: Belongs to the heat shock protein 70 family


    HSPA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP76_HUMAN, P17066
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage (By similarity)
    Induction: Only at higher temperatures, and no basal expression

         Genatlas biochemistry entry for HSPA6:
    heat shock 70kDa protein A6,structurally related to aconitase

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    HSPA6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA6:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HSPA6 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HSPA6:
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPA6
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA6

    Clone
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    OriGene clones in human, mouse for HSPA6 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA6 (NM_002155)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA6

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    golgi apparatus3
    nucleus3
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0070062extracellular vesicular exosome IDA19199708
    GO:0072562blood microparticle IDA--

    HSPA6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA6 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    3Influenza A
    Influenza A0.34
    Measles0.34
    4Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5MAPK signaling pathway
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HSPA6 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA6
        Parkin-Ubiquitin Proteasomal System pathway


    Selected Kegg Pathways  (Kegg details for HSPA6) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HSPA6: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HSPA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA6 (P170662, 3 ENSP000003102194) via UniProtKB, MINT, STRING, and/or I2D (see all 631)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929052, 3, ENSP000003505124MINT-7947479 I2D: score=1 STRING: ENSP00000350512
    IKBKGQ9Y6K92, 3MINT-48155 I2D: score=2 
    MAP3K1Q132332, 3MINT-48290 I2D: score=2 
    MAP3K14Q995582, 3MINT-48803 I2D: score=2 
    MAP3K3Q997592, 3MINT-48405 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006986response to unfolded protein TAS2327978

    HSPA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA6 (HSP76)

    2 Novoseek inferred chemical compound relationships for HSPA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdcl2 60 6 16155950 (5), 2327978 (1)
    atp 22.7 6 16155950 (4), 15635096 (1), 2327978 (1)



    HSPA6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSPA6 gene: 
    NM_002155.3  

    Unigene Cluster for HSPA6:

    Heat shock 70kDa protein 6 (HSP70B')
    Hs.654614  [show with all ESTs]
    Unigene Representative Sequence: NM_002155
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309758(uc001gaq.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat HSPA6 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HSPA6:
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA6 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HSPA6 (NM_002155)
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPA6
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HSPA6
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA6
      QuantiFast Probe-based Assays in human, mouse, rat HSPA6

    Additional mRNA sequence: 

    AK093925.1 AK223362.1 AK295212.1 AK312756.1 BC004279.1 BC035665.1 X51758.1 

    6 DOTS entries:

    DT.453313  DT.121462566  DT.100819773  DT.95346591  DT.100719416  DT.121462486 

    Selected AceView cDNA sequences (see all 509):

    BC031992 T29511 BX358269 NM_021642 U87561 BX952560 BX378100 CD368312 
    BQ023141 BC004279 AL118844 CD367627 AW452813 NM_001002274 CR593871 U87560 
    NM_001002275 X51758 BE645244 AL543318 BX378680 BU634221 AL540745 BI019743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAATTTT
    HSPA6 Expression
    About this image


    HSPA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    HSPA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654614
        Pathway & Disease-focused RT2 Profiler PCR Array including HSPA6: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSPA6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    78(a)
    many ↔ many
    5(11293060-11296611)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    76(a)
    many ↔ many
    LGf(897907-924982)
    zebrafish
    (Danio rerio)
    Actinopterygii mcm56
    MCM5 minichromosome maintenance deficient 5 (S. ce...
    79(a)
    many ↔ many
    3(26912773-26922329) ENSDARG00000029688
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43 neurotransmitter secretion chaperone 79(a)
    (best of 11)
      88E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 80(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSZ1(YHR064C)4 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) more   --   8(227141-225525) 856461  NP_011931.2 


    ENSEMBL Gene Tree for HSPA6 (if available)
    TreeFam Gene Tree for HSPA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA6 gene
    HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA142  HSPA22  HSPA1A2  
    16 SIMAP similar genes for HSPA6 using alignment to 1 protein entry:     HSP76_HUMAN:
    HSPA7    HSPA1A    HSPA1B    HSP70-1    HSPA1L    HSPA2
    HSPA8    LOC401308    HSPA5    HSPA9    HSPA14    HS24/p52
    HSPA13    HSPA4    HSPA4L    HSPH1

    HSPA6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HSPA6
    PGOHUM00000245047 PGOHUM00000237551


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA6 (see all 269)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30984871,2
    H--168042766(-) AGAGGT/GTCAAA 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs31233481,2
    H--168042769(+) GAACCA/TCTCTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs24994321,2
    H--168042792(-) CACTTC/TTTTTT 1 -- us2k14Minor allele frequency- T:0.00NS EA 416
    rs94274011,2
    C,F,H--168042827(+) TGATGC/GTGTGG 1 -- us2k113Minor allele frequency- G:0.04NS EA NA 746
    rs121213181,2
    C,F,H--168042920(+) TGGAAG/AAGAAG 1 -- us2k1 trp39Minor allele frequency- A:0.01NS EA 600
    rs109191701,2
    --168042950(+) GACAGC/TCCCTT 1 -- us2k10--------
    rs1874265961,2
    --168043032(+) GCCGTC/G/TGGCAA 1 -- us2k10--------
    rs1901929711,2
    --168043039(+) GCAAAC/TGTCTT 1 -- us2k10--------
    rs121171251,2
    C,F,H--168043100(+) TAAAGT/CTGACA 1 -- us2k116Minor allele frequency- C:0.48NS EA NA WA 810
    rs1809839101,2
    --168043121(+) CTTTTA/GGAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSPA6 (161494036 - 161496687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HSPA6 (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv74e199CNV Deletion23128226
    esv2718873CNV Deletion23290073
    dgv22n16CNV Deletion17901297
    nsv820341CNV Duplication20802225
    esv997087CNV Loss20482838
    nsv819523CNV Loss19587683
    nsv428257CNV Loss18775914
    dgv85n67CNV Loss20364138
    nsv8502CNV Loss18304495
    dgv17n21CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140555    OMIM disorders: --

    17 diseases for HSPA6:    
    About MalaCards
    legionellosis    toxoplasmosis    measles    childhood leukemia
    vascular disease    meningioma    influenza    chronic lymphocytic leukemia
    ulcerative colitis    cystic fibrosis    inflammatory bowel disease    hiv-1
    retinitis    leukemia    endotheliitis    neuronitis
    breast cancer


    HSPA6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HSPA6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 55.3 4 20348092 (1), 16782652 (1), 16155950 (1), 8940068 (1)

    Genetic Association Database (GAD): HSPA6
    Human Genome Epidemiology (HuGE) Navigator: HSPA6 (12 documents)

    Export disorders for HSPA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA6 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with HSPA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PubMed id 1346391)1, 2, 3 Leung T.K.C.... Lim L. (Genomics 1992)
    2. The human heat-shock protein family. Expression of a novel heat- inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. (PubMed id 2327978)1, 2, 9 Leung T.K.C.... Lim L. (Biochem. J. 1990)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    6. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    7. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    8. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    9. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3310 HGNC: 5239 AceView: HSPA6andFCGR2A Ensembl:ENSG00000173110 euGenes: HUgn3310
    ECgene: HSPA6 Kegg: 3310 H-InvDB: HSPA6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA6 gene:
    Search GeneIP for patents involving HSPA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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