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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA6 Gene

protein-coding   GIFtS: 67
GCID: GC01P161495

Heat Shock 70kDa Protein 6 (HSP70B')

(Previous name: heat shock 70kD protein 6 (HSP70B'))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 6 (HSP70B')1 2
Heat Shock 70kD Protein 6 (HSP70B')1 2
Heat Shock 70 KDa Protein B'2 3
Heat Shock 70 KDa Protein 62
HSP70B'3

External Ids:    HGNC: 52391   Entrez Gene: 33102   Ensembl: ENSG000001731107   OMIM: 1405555   UniProtKB: P170663   

Export aliases for HSPA6 gene to outside databases

Previous GC identifers: GC01P159211 GC01P157225 GC01P158271 GC01P158764 GC01P158765 GC01P158308 GC01P159760 GC01P132819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPA6 Gene: 
HSPA6 (heat shock 70kDa protein 6 (HSP70B')) is a protein-coding gene. Diseases associated with HSPA6 include toxoplasmosis, and measles, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include ATP binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage (By similarity)

Gene Wiki entry for HSPA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA6 gene promoter:
         p53   AML1a   NRSF form 1   FOXD1   CUTL1   NRSF form 2   E47   STAT3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

HSPA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P161495:  view genomic region     (about GC identifiers)

Start:
161,494,036 bp from pter      End:
161,496,687 bp from pter
Size:
2,652 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 6  
Size: 643 amino acids; 71028 Da
1 PDB 3D structure from and Proteopedia for HSPA6:
3FE1 (3D)    
Secondary accessions: Q1HBA8 Q8IYK7 Q9BT95

Explore the universe of human proteins at neXtProt for HSPA6: NX_P17066

Explore proteomics data for HSPA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17066

  • HSPA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA6 Protein Expression
    REFSEQ proteins: NP_002146.2  
    ENSEMBL proteins: 
     ENSP00000310219  

    Human Recombinant Protein Products for HSPA6: 
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    Novus Biologicals HSPA6 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSPA6
    Cloud-Clone Corp. Proteins for HSPA6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008180colocalizes with COP9 signalosome IDA18850735

    HSPA6 for ontologies           About GeneDecksing



    HSPA6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P17066

    ProtoNet protein and cluster: P17066

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP76_HUMAN, P17066
    Similarity: Belongs to the heat shock protein 70 family


    HSPA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP76_HUMAN, P17066
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage (By similarity)
    Induction: Only at higher temperatures, and no basal expression

         Genatlas biochemistry entry for HSPA6:
    heat shock 70kDa protein A6,structurally related to aconitase

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    HSPA6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA6:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPA6

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    SwitchGear 3'UTR luciferase reporter plasmidHSPA6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA6 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    CFTR folding and maturation (norm and CF)0.37
    3Influenza A
    Influenza A0.34
    Measles0.34
    4Proteolysis Putative ubiquitin pathway
    Proteolysis Putative ubiquitin pathway0.97
    5Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA6
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway


    5/6 GeneGo (Thomson Reuters) Pathways for HSPA6 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA6
        Parkin-Ubiquitin Proteasomal System pathway


    5/11         Kegg Pathways  (Kegg details for HSPA6) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/622 Interacting proteins for HSPA6 (P170662, 3 ENSP000003102194) via UniProtKB, MINT, STRING, and/or I2D (see all 622)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929052, 3, ENSP000003505124MINT-7947479 I2D: score=1 STRING: ENSP00000350512
    IKBKGQ9Y6K92, 3MINT-48155 I2D: score=2 
    MAP3K1Q132332, 3MINT-48290 I2D: score=2 
    MAP3K14Q995582, 3MINT-48803 I2D: score=2 
    MAP3K3Q997592, 3MINT-48405 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006986response to unfolded protein TAS2327978

    HSPA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPA6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA6 (HSP76)

    2 Novoseek inferred chemical compound relationships for HSPA6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdcl2 60 6 16155950 (5), 2327978 (1)
    atp 22.7 6 16155950 (4), 15635096 (1), 2327978 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPA6 / HSP76

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA6 gene: 
    NM_002155.3  

    Unigene Cluster for HSPA6:

    Heat shock 70kDa protein 6 (HSP70B')
    Hs.654614  [show with all ESTs]
    Unigene Representative Sequence: NM_002155
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000309758(uc001gaq.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA6:
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK093925.1 AK223362.1 AK295212.1 AK312756.1 BC004279.1 BC035665.1 X51758.1 

    6 DOTS entries:

    DT.453313  DT.121462566  DT.100819773  DT.95346591  DT.100719416  DT.121462486 

    24/509 AceView cDNA sequences (see all 509):

    F05222 BX378680 CR592864 U87568 U87565 NM_001002275 U87570 AI831007 
    AB050934 CR610288 BF445810 CR606721 BF591739 BM717638 BG058778 CD368961 
    BQ718336 BX359383 CR593201 U87567 CD367627 D56797 CR590610 CR617159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA6 expression in normal human tissues (normalized intensities)      HSPA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAATTTT
    HSPA6 Expression
    About this image


    HSPA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             trachea   
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See HSPA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA6

    SOURCE GeneReport for Unigene cluster: Hs.654614
        SABiosciences Expression via Pathway-Focused PCR Array including HSPA6: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSPA6 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    Uncharacterized protein
    82(a)
    82(a)
    1 ↔ many
    1 ↔ many
    2(52182510-52184444)
    2(52193792-52195726)
    lizard
    (Anolis carolinensis)
    Reptilia --
    HSPA26
    Uncharacterized protein
    76(a)
    58(a)
    possible ortholog
    possible ortholog
    LGf(897907-924982)
    GL343668.1(269397-271328)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-199o1.26
    hsp70.36
    (see all 6)
    si:ch211-199o1.2
    heat shock cognate 70-kd protein, tandem duplicate...
    (see all 6)
    78(a)
    78(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    8(25821041-25823733)
    3(26908016-26911371)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43 neurotransmitter secretion chaperone 79(a)
    (best of 11)
      88E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 80(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSZ1(YHR064C)4 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) more   --   8(227141-225525) 856461  NP_011931.2 


    ENSEMBL Gene Tree for HSPA6 (if available)
    TreeFam Gene Tree for HSPA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA6 gene
    HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA132  HSPA22  HSPA1A2  
    16 SIMAP similar genes for HSPA6 using alignment to 1 protein entry:     HSP76_HUMAN:
    HSPA7    HSPA1A    HSPA1B    HSP70-1    HSPA1L    HSPA2
    HSPA8    LOC401308    HSPA5    HSPA9    HSPA14    HS24/p52
    HSPA13    HSPA4    HSPA4L    HSPH1

    HSPA6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HSPA6
    PGOHUM00000245047 PGOHUM00000237551


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/269 SNPs in HSPA6 are shown (see all 269)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0607214
    ----see VAR_0607212 T K mis40--------
    VAR_0607184
    ----see VAR_0607182 P T mis40--------
    VAR_0607194
    ----see VAR_0607192 R Q mis40--------
    VAR_0607204
    ----see VAR_0607202 A V mis40--------
    VAR_0241824
    ----see VAR_0241822 L F mis40--------
    rs30984871,2
    H--168042766(-) AGAGGT/GTCAAA 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs31233481,2
    H--168042769(+) GAACCA/TCTCTG 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs24994321,2
    H--168042792(-) CACTTC/TTTTTT 1 -- us2k14Minor allele frequency- T:0.00NS EA 416
    rs94274011,2
    C,F,H--168042827(+) TGATGC/GTGTGG 1 -- us2k113Minor allele frequency- G:0.04NS EA NA 746
    rs121213181,2
    C,F,H--168042920(+) TGGAAG/AAGAAG 1 -- us2k1 trp39Minor allele frequency- A:0.01NS EA 600

    HapMap Linkage Disequilibrium report for HSPA6 (161494036 - 161496687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for HSPA6 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv74e199CNV Deletion23128226
    esv2718873CNV Deletion23290073
    dgv22n16CNV Deletion17901297
    nsv820341CNV Duplication20802225
    esv997087CNV Loss20482838
    nsv819523CNV Loss19587683
    nsv428257CNV Loss18775914
    dgv85n67CNV Loss20364138
    nsv8502CNV Loss18304495
    dgv17n21CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140555    OMIM disorders: --

    9 diseases for HSPA6:    About MalaCards
    toxoplasmosis    measles    vascular disease    meningioma
    chronic lymphocytic leukemia    influenza    leukemia    endotheliitis
    neuronitis


    HSPA6 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HSPA6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 55.3 4 20348092 (1), 16782652 (1), 16155950 (1), 8940068 (1)

    Genetic Association Database (GAD): HSPA6
    Human Genome Epidemiology (HuGE) Navigator: HSPA6 (12 documents)

    Export disorders for HSPA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA6 gene, integrated from 9 sources (see all 85):
    (articles sorted by number of sources associating them with HSPA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. (PubMed id 1346391)1, 2, 3 Leung T.K.C.... Lim L. (1992)
    2. The human heat-shock protein family. Expression of a novel heat- inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA. (PubMed id 2327978)1, 2, 9 Leung T.K.C.... Lim L. (1990)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    6. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    7. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    8. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    9. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    10. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3310 HGNC: 5239 AceView: HSPA6andFCGR2A Ensembl:ENSG00000173110 euGenes: HUgn3310
    ECgene: HSPA6 Kegg: 3310 H-InvDB: HSPA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA6 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA6 gene:
    Search GeneIP for patents involving HSPA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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