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HSPA5 Gene

protein-coding   GIFtS: 68
GCID: GC09M127997

Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)

(Previous names: heat shock 70kD protein 5 (glucose-regulated protein, 78kD))
(Previous symbol: GRP78)
  See HSPA5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)1 2     HEL-S-89n2
GRP781 2 3 5     MIF22
Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp782 3     Epididymis Secretory Sperm Binding Protein Li 89n2
Immunoglobulin Heavy Chain-Binding Protein2 3     BiP3
Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD)1     GRP-783
78 KDa Glucose-Regulated Protein2     Heat Shock 70 KDa Protein 53
BIP2     

External Ids:    HGNC: 52381   Entrez Gene: 33092   Ensembl: ENSG000000445747   OMIM: 1381205   UniProtKB: P110213   

Export aliases for HSPA5 gene to outside databases

Previous GC identifers: GC09M119111 GC09M119643 GC09M121450 GC09M123373 GC09M125076 GC09M127036 GC09M097610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA5 Gene:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the
lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As
this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the
cell.(provided by RefSeq, Sep 2010)

GeneCards Summary for HSPA5 Gene:
HSPA5 (heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)) is a protein-coding gene. Diseases associated with HSPA5 include borna disease, and spinocerebellar ataxia type 17. GO annotations related to this gene include ubiquitin protein ligase binding and calcium ion binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the
endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its
interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate

Gene Wiki entry for HSPA5 (Binding immunoglobulin protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA5 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA5 promoter sequence
   Search Chromatin IP Primers for HSPA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

HSPA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M127997:  view genomic region     (about GC identifiers)

Start:
127,997,127 bp from pter      End:
128,003,666 bp from pter
Size:
6,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021 (See protein sequence)
Recommended Name: 78 kDa glucose-regulated protein precursor  
Size: 654 amino acids; 72333 Da
Subunit: Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of
CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex
comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of
ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with
ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10 and MX1. Interacts with METTL23
5 PDB 3D structures from and Proteopedia for HSPA5:
3IUC (3D)        3LDL (3D)        3LDN (3D)        3LDO (3D)        3LDP (3D)    
Secondary accessions: B0QZ61 Q2EF78 Q9NPF1 Q9UK02

Explore the universe of human proteins at neXtProt for HSPA5: NX_P11021

Explore proteomics data for HSPA5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96, Lys113, Lys118, Lys213, Lys268, Lys326, Lys370, Lys376, Lys523, Lys547,
                                 Lys573, Lys601
  • Glycosylation2 at Thr69, Thr203, Thr643
  • Modification sites at PhosphoSitePlus

  • See HSPA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005338.1  
    ENSEMBL proteins: 
     ENSP00000324173  
    Reactome Protein details: P11021

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    Cloud-Clone Corp. Proteins for HSPA5

     
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    antibodies-online proteins for HSPA5 (17 products) 

     
    antibodies-online peptides for HSPA5

    HSPA5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA5
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    antibodies-online antibodies for HSPA5 (195 products) 

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    antibodies-online kits for HSPA5 (26 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P11021

    ProtoNet protein and cluster: P11021

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP78_HUMAN, P11021
    Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the
    endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its
    interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate

         Genatlas biochemistry entry for HSPA5:
    glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS16130169
    GO:0005515protein binding IPI11907036
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ISS--
    GO:0019904protein domain specific binding IPI12411443
         
    Find genes that share ontologies with HSPA5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA5:
     Decreased G3BP1 protein expres  Decreased Wnt reporter activit 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hspa5):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  homeostasis/metabolism  integument  mortality/aging  nervous system 
     normal  renal/urinary system  reproductive system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with HSPA5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hspa5tm1.1Alee for HSPA5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA5:
    hsa-mir-16-5p (MIRT031900), hsa-mir-335-5p (MIRT018562), hsa-mir-93-3p (MIRT038848)

    Block miRNA regulation of human, mouse, rat HSPA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA5 (see all 40):
    hsa-miR-3685 hsa-miR-3130-5p hsa-miR-16-1* hsa-miR-30d hsa-miR-105 hsa-miR-4275 hsa-miR-30a hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA5

    Gene Editing
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    Clone
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    Addgene plasmids for HSPA5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GRP78_HUMAN, P11021: Endoplasmic reticulum lumen. Melanosome. Cytoplasm (By similarity). Note=Identified by mass
    spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP11943137
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636

    Find genes that share ontologies with HSPA5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA5 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperones by ATF6-alpha0.00
    Activation of Chaperones by IRE1alpha0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    3Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    4Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    5Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43


    Find genes that share SuperPaths with HSPA5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HSPA5
        Translational Control

    Selected GeneGo (Thomson Reuters) Pathways for HSPA5 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for HSPA5
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway


    Selected Reactome Pathways for HSPA5 (see all 6)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Platelet degranulation
    ATF6-alpha activates chaperones
    PERK regulates gene expression
    IRE1alpha activates chaperones


    5 Kegg Pathways  (Kegg details for HSPA5):
        Protein export
    Protein processing in endoplasmic reticulum
    Antigen processing and presentation
    Thyroid hormone synthesis
    Prion diseases

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA5 (see all 9): 
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA5 (P110211, 2, 3 ENSP000003241734) via UniProtKB, MINT, STRING, and/or I2D (see all 1344)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0002576platelet degranulation TAS--
    GO:0006200ATP catabolic process ISS--
    GO:0006983ER overload response IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    Find genes that share ontologies with HSPA5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA5 (GRP78)

    1 DrugBank Compound for HSPA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 17139284 17016423

    Selected Novoseek inferred chemical compound relationships for HSPA5 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 87.1 67 10760948 (7), 8454000 (4), 18477628 (3), 18228003 (3) (see all 33)
    trans-4,5-dihydroxy-1,2-dithiane 84.3 4 9268305 (2), 9268304 (1), 16150886 (1)
    thapsigargin 77.5 57 9595551 (6), 1506413 (4), 8844337 (3), 12516782 (3) (see all 32)
    11-deoxy-16,16-dimethyl-pge2 73.3 4 15226156 (4)
    2-deoxyglucose 57.7 26 19766678 (6), 15895530 (1), 17612505 (1), 17941090 (1) (see all 13)
    kar 2 57.4 2 2071610 (1), 9428766 (1)
    azetidine 54.2 5 12076252 (2), 9498488 (2), 8972185 (1)
    6-aminonicotinamide 54.1 11 10198218 (4), 10692493 (3), 7850801 (1)
    calcium 47.2 76 16418174 (7), 9388233 (5), 1649196 (4), 9477774 (4) (see all 36)
    dithiothreitol 47 14 7876163 (2), 2122977 (2), 11796709 (1), 9159886 (1) (see all 10)

    1 PharmGKB related drug/compound annotation for HSPA5 gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  



    Find genes that share compounds with HSPA5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA5 gene: 
    NM_005347.4  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000324460(uc004bpn.3)
    miRNA
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    Selected AceView cDNA sequences (see all 1367):

    BG697173 CA441465 AI564586 BP350759 AW196039 CB124617 BM663199 CK905717 
    CA394612 CB155468 AA328108 AW515148 BM672939 BI439212 BF939468 CB268510 
    BM771407 AI954893 BM759958 AI879735 AA374313 BE515151 BP353083 BQ425434 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSPA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATCTGGT
    HSPA5 Expression
    About this image


    HSPA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Eye (Sensory Organs)
             Lens
    HSPA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA5 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA5 (see all 9): 
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA5 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa51 , 5 heat shock protein 51, 5 92.35(n)1
    98.62(a)1
      2 (22.94 cM)5
    148281  NM_001163434.11  NP_001156906.11 
     347719705 
    chicken
    (Gallus gallus)
    Aves HSPA51 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) less 84.59(n)
    97.64(a)
      396487  NM_205491.1  NP_990822.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA56
    heat shock 70kDa protein 5 (glucose-regulated prot...
    94(a)
    1 ↔ 1
    AAWZ02037731(3047-14277)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspa5-prov2 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) less 79.8(n)    BC041200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261162 Danio rerio cDNA clone MGC55994 IMAGE3819692, complete cds less 78.19(n)    BC063946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-31 Heat shock protein cognate 3 73.49(n)
    82.52(a)
      32133  NM_167307.1  NP_727564.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-31 hsp-3 71.02(n)
    79.69(a)
      180880  NM_076618.5  NP_509019.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAR2(YJL034W)4
    KAR21
    ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p less4
    KAR21
    64.59(n)1
    68.8(a)1
      10(381327-383375)4
    8534181, 4  NP_012500.31  NP_012500.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BIP11 BIP1 64.91(n)
    70.93(a)
      832950  NM_122737.3  NP_198206.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01159001 Os02g0115900 66.13(n)
    71.2(a)
      4328075  NM_001052210.1  NP_001045675.1 


    ENSEMBL Gene Tree for HSPA5 (if available)
    TreeFam Gene Tree for HSPA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA5 gene
    HSPA82  HSPA92  HSPA1L2  HSPA1B2  HSPA62  HSPA142  HSPA22  HSPA1A2  
    14 SIMAP similar genes for HSPA5 using alignment to 1 protein entry:     GRP78_HUMAN:
    HSPA1B    HSPA1L    HSPA2    HSPA6    HSPA1A    HSPA7
    HSPA8    LOC401308    HSPA9    HSPA14    HS24/p52    HSPA13
    HSPA4    HSPH1

    Find genes that share paralogs with HSPA5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HSPA5
    PGOHUM00000244679 PGOHUM00000246127


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA5 (see all 258)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391229591,2
    --97618100(+) ACTCAA/GGAATT 1 -- us2k10--------
    rs1806859471,2
    --97618222(+) CAACAC/TTGACC 1 -- us2k10--------
    rs107136351,2
    C--128005502(+) ATCTCA/-AAAAA 1 -- us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs4214291,2
    C,F--128008891(-) CCTGAG/ATATCT 1 -- ds50017Minor allele frequency- A:0.07NS NA 192
    rs40758561,2
    C,F--128008957(-) atggtG/Atgatc 1 -- ds50018Minor allele frequency- A:0.04NA NS CSA 190
    rs1858069121,2
    --128009012(+) AAAAAA/TAAATA 1 -- ds50010--------
    rs2003076071,2
    --128009013(+) AAAAA-/TAATAT 1 -- ds50010--------
    rs20053421,2
    C--128009014(-) TATATA/TTTTTT 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs74689161,2
    C--128009016(+) AAAAAT/AATATA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs586129091,2
    --128009028(+) ATATAC/TACATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HSPA5 (127997127 - 128003666 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPA5: --
    Human Gene Mutation Database (HGMD): HSPA5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA5
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138120    OMIM disorders: --

    UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
  • Note=Autoantigen in rheumatoid arthritis

  • 3 diseases for HSPA5:    
    About MalaCards
    borna disease    spinocerebellar ataxia type 17    wolfram syndrome


    Find genes that share disorders with HSPA5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSPA5 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 63.6 74 9806766 (2), 16878978 (2), 9434171 (1), 9482255 (1) (see all 52)
    hepatitis halothane 46.8 1 8415876 (1)
    solid tumor 38.3 5 16595926 (2), 17161515 (1), 8113109 (1)
    cancer 37.7 68 16297569 (6), 16472112 (4), 20097177 (3), 17440054 (2) (see all 36)
    colon cancer 32.4 8 10198218 (3), 20204278 (1), 15778089 (1), 16182273 (1) (see all 6)
    alzheimers disease 29.8 5 10963362 (1), 18781276 (1), 2005999 (1), 10587643 (1) (see all 5)
    tumors 27.4 105 15514946 (7), 18331622 (6), 15380518 (5), 10752676 (3) (see all 49)
    hepatocellular carcinoma 27.2 18 20082722 (8), 20087778 (2), 12713871 (2), 19533686 (1) (see all 7)
    cell damage 26.9 5 11113529 (3), 18813861 (1)
    prostate cancer 24 34 19097122 (4), 17062670 (4), 17640713 (4), 10760948 (3) (see all 14)

    Genetic Association Database (GAD): HSPA5
    Human Genome Epidemiology (HuGE) Navigator: HSPA5 (10 documents)

    Export disorders for HSPA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA5 gene, integrated from 10 sources (see all 977):
    (articles sorted by number of sources associating them with HSPA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis. (PubMed id 19533686)1, 4, 9 Zhu X....Kung H.F. (Int. J. Cancer 2009)
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    3. Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population. (PubMed id 20525207)1, 4 Zhu X....Kung H.F. (BMC Med. Genet. 2010)
    4. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)1, 2 Hosokawa N.... Nagata K. (J. Biol. Chem. 2008)
    5. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2 Christianson J.C.... Kopito R.R. (Nat. Cell Biol. 2008)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    7. HSPA5 promoter polymorphisms and risk of Parkinson's disease in Taiwan. (PubMed id 18343577)1, 4 Chen C.M....Lee-Chen G.J. (Neurosci. Lett. 2008)
    8. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    9. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    10. Functional polymorphisms of HSPA5: possible association with bipolar disorder. (PubMed id 16168956)1, 4 Kakiuchi C....Kato T. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3309 HGNC: 5238 AceView: HSPA5 Ensembl:ENSG00000044574 euGenes: HUgn3309
    ECgene: HSPA5 Kegg: 3309 H-InvDB: HSPA5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA5 gene:
    Search GeneIP for patents involving HSPA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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