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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPA5 Gene

protein-coding GIFtS: 69
GCID: GC09M127997

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

(Previous names: heat shock 70kD protein 5 (glucose-regulated protein, 78kD)...)
(Previous symbol: GRP78)

Explore 113 diseases affiliated with
HSPA5 via

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)¹ ²		78 KDa Glucose-Regulated Protein²
GRP78¹ ² ³ ⁵		BIP²
BiP¹ ³		MIF2²
Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78² ³		GRP-78³
Immunoglobulin Heavy Chain-Binding Protein² ³		Heat Shock 70 KDa Protein 5³
Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD)¹

External Ids:	HGNC: 5238¹	Entrez Gene: 3309²	Ensembl: ENSG00000044574⁷	OMIM: 138120⁵	UniProtKB: P11021³

Export aliases for HSPA5 gene to outside databases

Previous GC identifers: GC09M119111 GC09M119643 GC09M121450 GC09M123373 GC09M125076 GC09M127036 GC09M097610

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA5:

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen

of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein

interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.(provided by

RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021

Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

Gene Wiki entry for HSPA5 (Binding immunoglobulin protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPA5 gene promoter:
CREB AP-1 ATF-2 deltaCREB c-Myb c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA5 promoter sequence

Search SABiosciences Chromatin IP Primers for HSPA5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3

HSPA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA5 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M127997: view genomic region (about GC identifiers)

Start:	127,997,127 bp from pter	End:	128,003,661 bp from pter
Size:	6,535 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021 (See protein sequence)

Recommended Name: 78 kDa glucose-regulated protein precursor

Size: 654 amino acids; 72333 Da

Subunit: Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of

CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex

comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29,

but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1,

OS9, SEL1L and SYVN1. Interacts with MX1 (By similarity)

Subcellular location: Endoplasmic reticulum lumen. Melanosome. Cytoplasm (By similarity). Note=Identified by mass

spectrometry in melanosome fractions from stage I to stage IV

5 PDB 3D structures from and Proteopedia for HSPA5:

3IUC (3D)

3LDL (3D)

3LDN (3D)

3LDO (3D)

3LDP (3D)

Secondary accessions: B0QZ61 Q2EF78 Q9NPF1 Q9UK02

Explore the universe of human proteins at neXtProt for HSPA5: NX_P11021

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11021

HSPA5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005338.1

ENSEMBL proteins:

ENSP00000324173

Reactome Protein details: P11021
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	ProSpec Recombinant Protein for HSPA5
	Uscn Proteins for HSPA5

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IMP	11943137
GO:0005783	endoplasmic reticulum	TAS	16130169
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636

HSPA5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HSPA5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA5 for domains About GeneDecksing

2 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR013126 Hsp_70_fam

Graphical View of Domain Structure for InterPro Entry P11021

ProtoNet protein and cluster: P11021

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021

Similarity: Belongs to the heat shock protein 70 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021

Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

Genatlas biochemistry entry for HSPA5:

glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2

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		hsa-miR-3685 hsa-miR-3130-5p hsa-miR-16-1* hsa-miR-30d hsa-miR-105 hsa-miR-4275 hsa-miR-30a hsa-miR-155*

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA5

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	TAS	16130169
GO:0005515	protein binding	IPI	19632185
GO:0005524	ATP binding	IEA	--
GO:0016887	ATPase activity	ISS	--
GO:0019904	protein domain specific binding	IPI	12411443

HSPA5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HSPA5:

Decreased G3BP1 protein expres

Decreased Wnt reporter activit

Animal Models:
Mouse knock-out Hspa5^tm1.1Alee for HSPA5
15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hspa5):

cardiovascular system	cellular	craniofacial	digestive/alimentary	embryogenesis
growth/size	homeostasis/metabolism	integument	mortality/aging	nervous system
normal	renal/urinary system	reproductive system	respiratory system	tumorigenesis

HSPA5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSPA5

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

1 Cell Signaling Technology (CST) Pathway for HSPA5

Translational Control

5/6 GeneGo (Thomson Reuters) Pathways for HSPA5 (see all 6)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Regulation of degradation of deltaF508 CFTR in CF
	CFTR folding and maturation (norm and CF)
	Proteolysis Putative ubiquitin pathway

2 BioSystems Pathways for HSPA5

	MAPK signaling pathway
	Parkin-Ubiquitin Proteasomal System pathway

5/15 Reactome Pathways for HSPA5 (see all 15)

	Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)
	Hemostasis
	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Adaptive Immune System
	Response to elevated platelet cytosolic Ca2+

4 Kegg Pathways (Kegg details for HSPA5):

	Protein export
	Protein processing in endoplasmic reticulum
	Antigen processing and presentation
	Prion diseases

HSPA5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1195 Interacting proteins for HSPA5 (P11021^{1, 2, 3} ENSP00000324173⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1195)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	TAS	--
GO:0006200	ATP catabolic process	ISS	--
GO:0006983	ER overload response	IEA	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0007596	blood coagulation	TAS	--

HSPA5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPA5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA5

1 DrugBank Compound for HSPA5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Antihemophilic Factor	AHF (see all 3)	--	target	chaperone	9607108 17139284 17016423

10/98 Novoseek chemical compound relationships for HSPA5 gene (see all 98) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tunicamycin	87.1	67	10760948 (7), 8454000 (4), 18477628 (3), 18228003 (3) (see all 33)
trans-4,5-dihydroxy-1,2-dithiane	84.3	4	9268305 (2), 9268304 (1), 16150886 (1)
thapsigargin	77.5	57	9595551 (6), 1506413 (4), 8844337 (3), 12516782 (3) (see all 32)
11-deoxy-16,16-dimethyl-pge2	73.3	4	15226156 (4)
2-deoxyglucose	57.7	26	19766678 (6), 15895530 (1), 17612505 (1), 17941090 (1) (see all 13)
kar 2	57.4	2	2071610 (1), 9428766 (1)
azetidine	54.2	5	12076252 (2), 9498488 (2), 8972185 (1)
6-aminonicotinamide	54.1	11	10198218 (4), 10692493 (3), 7850801 (1)
calcium	47.2	76	16418174 (7), 9388233 (5), 1649196 (4), 9477774 (4) (see all 36)
dithiothreitol	47	14	7876163 (2), 2122977 (2), 11796709 (1), 9159886 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about HSPA5 / GRP78

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPA5 gene:

NM_005347.4

Unigene Cluster for HSPA5:

Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Hs.743241 [show with all ESTs]

Unigene Representative Sequence: NM_005347

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000324460(uc004bpn.3)

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Additional cDNA sequence:

AF188611.1 AF216292.1 AJ271729.1 AK129617.1 AK293604.1 BC020235.1 X87949.1

24/38 DOTS entries (see all 38):

DT.100735994 DT.100735949 DT.100866457 DT.91778195 DT.97861539 DT.95343265 DT.121196325 DT.121196336

DT.97868449 DT.121196285 DT.97853455 DT.121196307 DT.100735971 DT.100736014 DT.121196310 DT.95296188

DT.97868439 DT.100034725 DT.121271258 DT.100658122 DT.121196305 DT.91778233 DT.95252068 DT.95295959

24/1367 AceView cDNA sequences (see all 1367):

BU736038 BQ004912 BM827014 BM453295 BP380076 AL043258 AW449037 BQ717770

CB106885 BP367119 BX439221 BM353167 AL044593 BM825472 AI926841 BF094889

BF923835 CN481072 CB149040 AA160899 BX414039 BM841556 AL040204 AA025918

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCATCTGGT

About this image

HSPA5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPA5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPA5

SOURCE GeneReport for Unigene cluster: Hs.743241

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA5 (see all 9):

Stress & Toxicity PathwayFinder in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Neurotoxicity in human mouse rat

Cellular Stress Responses in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA5 gene from 9/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSPA5¹	heat shock 70kDa protein 5 (glucose-regulated protein, more	84.55(n) 97.36(a)		396487 NM_205491.1 NP_990822.1
lizard (Anolis carolinensis)	Reptilia	HSPA5⁶ --	--	93(a) 53(a)	1 ↔ 1 possible ortholog	AAWZ02037731(6139-11086) GL343668.1(269397-271328)
African clawed frog (Xenopus laevis)	Amphibia	hspa5-prov²	heat shock 70kDa protein 5 (glucose-regulated protein, more	79.8(n)		BC041200.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26116²	Danio rerio cDNA clone MGC55994 IMAGE3819692, complete more	78.19(n)		BC063946.1
fruit fly (Drosophila melanogaster)	Insecta	Hsc70-3¹	Heat shock protein cognate 3	72.79(n) 81.01(a)		32133 NM_078577.2 NP_511132.2
worm (Caenorhabditis elegans)	Secernentea	hsp-3¹	Protein HSP-3	69.94(n) 78.03(a)		180880 NM_076618.4 NP_509019.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	KAR2(YJL034W)⁴ KAR2¹	ATPase involved in protein import into the ER, also more⁴ Kar2p¹	64.33(n)¹ 68.26(a)¹		10(381327-383375)⁴ 853418^{1, 4} NP_012500.3¹ NP_012500.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	BIP1¹	Luminal-binding protein 1	64.48(n) 70.27(a)		832950 NM_122737.3 NP_198206.1
rice (Oryza sativa)	Liliopsida	Os02g0115900¹	hypothetical protein	65.67(n) 70.53(a)		4328075 NM_001052210.1 NP_001045675.1

ENSEMBL Gene Tree for HSPA5 (if available)
TreeFam Gene Tree for HSPA5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HSPA5 gene

HSPA8² HSPA1L² HSPA1B² HSPA6² HSPA14² HSPA13² HSPA1A²

14 SIMAP similar genes for HSPA5 using alignment to 1 protein entry: GRP78_HUMAN:

HSPA1L HSPA2 HSPA6 HSPA1A HSPA7 HSPA1B

HSPA8 LOC401308 HSPA9 HSPA14 HS24/p52 HSPA13

HSPA4 HSPH1

HSPA5 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for HSPA5
PGOHUM00000244679 PGOHUM00000246127

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs421429^1,2	C,F,	--	127996712(-)	`CCTGAG/ATATCT`	4	--	ds500¹ int¹		7		NS NA	192
rs4075856^1,2	C,F,	--	127996778(-)	`atggtG/Atgatc`	4	--	ds500¹ int¹		8		NA NS CSA	190
rs185806912^1,2		--	127996833(+)	`AAAAAA/TAAATA`	4	--	ds500¹ int¹		0	--	--	--	--
rs200307607^1,2		--	127996834(+)	`AAAAA-/TAATAT`	4	--	int¹ ds500¹		0	--	--	--	--
rs2005342^1,2	C,	--	127996835(-)	`TATATA/TTTTTT`	4	--	ds500¹ int¹		2		NA	4
rs7468916^1,2	C,	--	127996837(+)	`AAAAAT/AATATA`	4	--	int¹ ds500¹		1		NA	2
rs58612909^1,2		--	127996849(+)	`ATATAC/TACATA`	4	--	ds500¹ int¹		0	--	--	--	--
rs201713801^1,2		--	127996886(+)	`ATAGT-/ATAC ATATT`	4	--	int¹ ds500¹		0	--	--	--	--
rs201273455^1,2		--	127996910(+)	`ATATA-/TGTATA`	4	--	ds500¹ int¹		0	--	--	--	--
rs199578591^1,2		--	127996913(+)	`TATGT-/ATAC ATATT`	4	--	int¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HSPA5 (127997127 - 128003661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSPA5: --
Human Gene Mutation Database (HGMD): HSPA5

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSPA5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA5 for disorders About GeneDecksing

OMIM gene information: 138120 OMIM disorders: --

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021

Note=Autoantigen in rheumatoid arthritis

20/113 diseases for HSPA5 (see all 113): About MalaCards

factor v and factor viii alpha 1-antitrypsin deficiency spinocerebellar ataxia type 17 retinol binding protein

non-small cell lung carcinoma amyotrophic lateral sclerosis myotonic dystrophy type 1 von willebrand's disease

pre-eclampsia osteogenesis imperfecta myotonic dystrophy transient cerebral ischemia

spinocerebellar ataxia lateral sclerosis japanese encephalitis olfactory neuroblastoma

squamous cell carcinoma b-cell lymphomas bipolar i disorder ankylosing spondylitis

10/54 Novoseek disease relationships for HSPA5 gene (see all 54) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	63.6	74	9806766 (2), 16878978 (2), 9434171 (1), 9482255 (1) (see all 52)
hepatitis halothane	46.8	1	8415876 (1)
solid tumor	38.3	5	16595926 (2), 17161515 (1), 8113109 (1)
cancer	37.7	68	16297569 (6), 16472112 (4), 20097177 (3), 17440054 (2) (see all 36)
colon cancer	32.4	8	10198218 (3), 20204278 (1), 15778089 (1), 16182273 (1) (see all 6)
alzheimers disease	29.8	5	10963362 (1), 18781276 (1), 2005999 (1), 10587643 (1) (see all 5)
tumors	27.4	105	15514946 (7), 18331622 (6), 15380518 (5), 10752676 (3) (see all 49)
hepatocellular carcinoma	27.2	18	20082722 (8), 20087778 (2), 12713871 (2), 19533686 (1) (see all 7)
cell damage	26.9	5	11113529 (3), 18813861 (1)
prostate cancer	24	34	19097122 (4), 17062670 (4), 17640713 (4), 10760948 (3) (see all 14)

Genetic Association Database (GAD): HSPA5
Human Genome Epidemiology (HuGE) Navigator: HSPA5 (10 documents)

Export disorders for HSPA5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSPA5 gene, integrated from 9 sources (see all 897):
(articles sorted by number of sources associating them with HSPA5)

Utopia: connect your pdf to the dynamic
world of online information

Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)^{1, 2} Hosokawa N.... Nagata K. (2008)
OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)^{1, 2} Christianson J.C.... Kopito R.R. (2008)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
Functional polymorphisms of HSPA5: possible association with bipolar disorder. (PubMed id 16168956)^{1, 4} Kakiuchi C....Kato T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{1, 2} Basrur V.... Appella E. (2003)
A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)^{1, 2} Meunier L....Hendershot L.M. (2002)
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis. (PubMed id 11160188)^{1, 2} Corrigall V.M.... Panayi G.S. (2001)
A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)^{1, 2} Ji H.... Simpson R.J. (1997)
Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2. (PubMed id 9150946)^{1, 2} Rasmussen R.K.... Dorow D.S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3309	HGNC: 5238	AceView: HSPA5	Ensembl:ENSG00000044574	euGenes: HUgn3309
ECgene: HSPA5	Kegg: 3309	H-InvDB: HSPA5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSPA5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPA5	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa5/

Intellectual Property for HSPA5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HSPA5 gene:
Search GeneIP for patents involving HSPA5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

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HSPA5 Gene

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

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