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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA5 Gene

protein-coding   GIFtS: 70
GCID: GC09M127997

Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)

(Previous names: heat shock 70kD protein 5 (glucose-regulated protein, 78kD))
(Previous symbol: GRP78)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)1 2     BIP2
GRP781 2 3 5     MIF22
Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp782 3     BiP3
Immunoglobulin Heavy Chain-Binding Protein2 3     GRP-783
Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD)1     Heat Shock 70 KDa Protein 53
78 KDa Glucose-Regulated Protein2     

External Ids:    HGNC: 52381   Entrez Gene: 33092   Ensembl: ENSG000000445747   OMIM: 1381205   UniProtKB: P110213   

Export aliases for HSPA5 gene to outside databases

Previous GC identifers: GC09M119111 GC09M119643 GC09M121450 GC09M123373 GC09M125076 GC09M127036 GC09M097610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA5 Gene:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the
lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As
this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the
cell.(provided by RefSeq, Sep 2010)

GeneCards Summary for HSPA5 Gene: 
HSPA5 (heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)) is a protein-coding gene. Diseases associated with HSPA5 include spinocerebellar ataxia type 17, and borna disease, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include ubiquitin protein ligase binding and calcium ion binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

Gene Wiki entry for HSPA5 (Binding immunoglobulin protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA5 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

HSPA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M127997:  view genomic region     (about GC identifiers)

Start:
127,997,127 bp from pter      End:
128,003,666 bp from pter
Size:
6,540 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021 (See protein sequence)
Recommended Name: 78 kDa glucose-regulated protein precursor  
Size: 654 amino acids; 72333 Da
Subunit: Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of
CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex
comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of
ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with
ERLEC1, OS9, SEL1L and SYVN1. Interacts with MX1 (By similarity)
Subcellular location: Endoplasmic reticulum lumen. Melanosome. Cytoplasm (By similarity). Note=Identified by mass
spectrometry in melanosome fractions from stage I to stage IV
5 PDB 3D structures from and Proteopedia for HSPA5:
3IUC (3D)        3LDL (3D)        3LDN (3D)        3LDO (3D)        3LDP (3D)    
Secondary accessions: B0QZ61 Q2EF78 Q9NPF1 Q9UK02

Explore the universe of human proteins at neXtProt for HSPA5: NX_P11021

Explore proteomics data for HSPA5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11021

  • HSPA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA5 Protein Expression
    REFSEQ proteins: NP_005338.1  
    ENSEMBL proteins: 
     ENSP00000324173  
    Reactome Protein details: P11021
    Human Recombinant Protein Products for HSPA5: 
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    Novus Biologicals HSPA5 Proteins
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    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for HSPA5
    Cloud-Clone Corp. Proteins for HSPA5 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP11943137
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636

    HSPA5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P11021

    ProtoNet protein and cluster: P11021

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
    Similarity: Belongs to the heat shock protein 70 family


    HSPA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GRP78_HUMAN, P11021
    Function: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

         Genatlas biochemistry entry for HSPA5:
    glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding TAS16130169
    GO:0005515protein binding IPI11907036
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ISS--
    GO:0019904protein domain specific binding IPI12411443
         
    HSPA5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA5:
     Decreased G3BP1 protein expres  Decreased Wnt reporter activit 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hspa5):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  homeostasis/metabolism  integument  mortality/aging  nervous system 
     normal  renal/urinary system  reproductive system  respiratory system  tumorigenesis 

    HSPA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hspa5tm1.1Alee for HSPA5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA5 About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    3Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    4Activation of Chaperone Genes by ATF6-alpha
    Activation of Chaperone Genes by ATF6-alpha0.62
    Activation of Chaperones by ATF6-alpha0.62
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA5
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway


    1 Cell Signaling Technology (CST) Pathway for HSPA5
        Translational Control

    5/6 GeneGo (Thomson Reuters) Pathways for HSPA5 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for HSPA5
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway


    5/14        Reactome Pathways for HSPA5 (see all 14)
        Hemostasis
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Adaptive Immune System
    Response to elevated platelet cytosolic Ca2+
    Platelet degranulation


    5         Kegg Pathways  (Kegg details for HSPA5):
        Protein export
    Protein processing in endoplasmic reticulum
    Antigen processing and presentation
    Thyroid hormone synthesis
    Prion diseases


    HSPA5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1251 Interacting proteins for HSPA5 (P110211, 2, 3 ENSP000003241734) via UniProtKB, MINT, STRING, and/or I2D (see all 1251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0002576platelet degranulation TAS--
    GO:0006200ATP catabolic process ISS--
    GO:0006983ER overload response IEA--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    HSPA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPA5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HSPA5 (GRP78)

    1 DrugBank Compound for HSPA5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 17139284 17016423

    10/98 Novoseek inferred chemical compound relationships for HSPA5 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 87.1 67 10760948 (7), 8454000 (4), 18477628 (3), 18228003 (3) (see all 33)
    trans-4,5-dihydroxy-1,2-dithiane 84.3 4 9268305 (2), 9268304 (1), 16150886 (1)
    thapsigargin 77.5 57 9595551 (6), 1506413 (4), 8844337 (3), 12516782 (3) (see all 32)
    11-deoxy-16,16-dimethyl-pge2 73.3 4 15226156 (4)
    2-deoxyglucose 57.7 26 19766678 (6), 15895530 (1), 17612505 (1), 17941090 (1) (see all 13)
    kar 2 57.4 2 2071610 (1), 9428766 (1)
    azetidine 54.2 5 12076252 (2), 9498488 (2), 8972185 (1)
    6-aminonicotinamide 54.1 11 10198218 (4), 10692493 (3), 7850801 (1)
    calcium 47.2 76 16418174 (7), 9388233 (5), 1649196 (4), 9477774 (4) (see all 36)
    dithiothreitol 47 14 7876163 (2), 2122977 (2), 11796709 (1), 9159886 (1) (see all 10)

    1 PharmGKB related drug/compound annotation for HSPA5 gene    About this table
    Drug/compound PharmGKB Annotation
    Platinum compoundsCA  

    Search CenterWatch for drugs/clinical trials and news about HSPA5 / GRP78

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for HSPA5 gene: 
    NM_005347.4  

    Unigene Cluster for HSPA5:

    Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
    Hs.743241  [show with all ESTs]
    Unigene Representative Sequence: NM_005347
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000324460(uc004bpn.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF188611.1 AF216292.1 AJ271729.1 AK129617.1 AK293604.1 BC020235.1 X87949.1 

    24/38 DOTS entries (see all 38):

    DT.100735994  DT.100735949  DT.100866457  DT.91778195  DT.97861539  DT.95343265  DT.121196325  DT.121196336 
    DT.97868449  DT.121196285  DT.97853455  DT.121196307  DT.100735971  DT.100736014  DT.121196310  DT.95296188 
    DT.97868439  DT.100034725  DT.121271258  DT.100658122  DT.121196305  DT.91778233  DT.95252068  DT.95295959 

    24/1367 AceView cDNA sequences (see all 1367):

    CB124535 BM926873 AI521102 CD107890 AA111963 BE515151 AI879735 BE042654 
    AJ271729 BF149123 BQ278527 AA328108 CA390957 CB149040 BQ717770 AA318918 
    CA865628 BP353083 BP365452 BG253599 CB044861 BP352668 BX433541 CB164352 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA5 expression in normal human tissues (normalized intensities)      HSPA5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATCTGGT
    HSPA5 Expression
    About this image


    HSPA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             cd31+ cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See HSPA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA5

    SOURCE GeneReport for Unigene cluster: Hs.743241
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA5 (see all 9): 
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              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Neurotoxicity in human mouse rat
              Cellular Stress Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA5 gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa51 , 5 heat shock protein 51, 5 92.35(n)1
    98.62(a)1
      2 (22.94 cM)5
    148281  NM_001163434.11  NP_001156906.11 
     347719705 
    chicken
    (Gallus gallus)
    Aves HSPA51 heat shock 70kDa protein 5 (glucose-regulated protein, more 84.55(n)
    97.36(a)
      396487  NM_205491.1  NP_990822.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia hspa5-prov2 heat shock 70kDa protein 5 (glucose-regulated protein, more 79.8(n)    BC041200.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261162 Danio rerio cDNA clone MGC55994 IMAGE3819692, complete more 78.19(n)    BC063946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-31 Heat shock protein cognate 3 72.79(n)
    81.01(a)
      32133  NM_078577.2  NP_511132.2 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-31 Protein HSP-3 69.94(n)
    78.03(a)
      180880  NM_076618.4  NP_509019.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KAR2(YJL034W)4
    KAR21
    ATPase involved in protein import into the ER, also more4
    Kar2p1
    64.33(n)1
    68.26(a)1
      10(381327-383375)4
    8534181, 4  NP_012500.31  NP_012500.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BIP11 Luminal-binding protein 1 64.48(n)
    70.27(a)
      832950  NM_122737.3  NP_198206.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01159001 hypothetical protein 65.67(n)
    70.53(a)
      4328075  NM_001052210.1  NP_001045675.1 


    ENSEMBL Gene Tree for HSPA5 (if available)
    TreeFam Gene Tree for HSPA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA5 gene
    HSPA82  HSPA92  HSPA1L2  HSPA1B2  HSPA62  HSPA132  HSPA22  HSPA1A2  
    14 SIMAP similar genes for HSPA5 using alignment to 1 protein entry:     GRP78_HUMAN:
    HSPA1B    HSPA1L    HSPA2    HSPA6    HSPA1A    HSPA7
    HSPA8    LOC401308    HSPA9    HSPA14    HS24/p52    HSPA13
    HSPA4    HSPH1

    HSPA5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HSPA5
    PGOHUM00000244679 PGOHUM00000246127


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 SNPs in HSPA5 are shown (see all 258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391229591,2
    --97618100(+) ACTCAA/GGAATT 1 -- us2k10--------
    rs1806859471,2
    --97618222(+) CAACAC/TTGACC 1 -- us2k10--------
    rs107136351,2
    C--128005502(+) ATCTCA/-AAAAA 1 -- us2k1 trp31Minor allele frequency- -:0.00NA 2
    rs4214291,2
    C,F--128008891(-) CCTGAG/ATATCT 1 -- ds50017Minor allele frequency- A:0.07NS NA 192
    rs40758561,2
    C,F--128008957(-) atggtG/Atgatc 1 -- ds50018Minor allele frequency- A:0.04NA NS CSA 190
    rs1858069121,2
    --128009012(+) AAAAAA/TAAATA 1 -- ds50010--------
    rs2003076071,2
    --128009013(+) AAAAA-/TAATAT 1 -- ds50010--------
    rs20053421,2
    C--128009014(-) TATATA/TTTTTT 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs74689161,2
    C--128009016(+) AAAAAT/AATATA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs586129091,2
    --128009028(+) ATATAC/TACATA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HSPA5 (127997127 - 128003666 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSPA5: --

    Human Gene Mutation Database (HGMD): HSPA5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA5
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138120    OMIM disorders: --

    UniProtKB/Swiss-Prot: GRP78_HUMAN, P11021
  • Note=Autoantigen in rheumatoid arthritis

  • 20/103 diseases for HSPA5 (see all 103):    About MalaCards
    spinocerebellar ataxia type 17    borna disease    olfactory neuroblastoma    myotonic dystrophy type 1
    lafora disease    wolfram syndrome    japanese encephalitis    transient cerebral ischemia
    von willebrand's disease    alpha 1-antitrypsin deficiency    osteogenesis imperfecta    myotonic dystrophy
    prion disease    bipolar i disorder    goiter    hypoglycemia
    sjogren's syndrome    thyroid cancer    pick's disease    spinocerebellar ataxia


    HSPA5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/54 Novoseek inferred disease relationships for HSPA5 gene (see all 54)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 63.6 74 9806766 (2), 16878978 (2), 9434171 (1), 9482255 (1) (see all 52)
    hepatitis halothane 46.8 1 8415876 (1)
    solid tumor 38.3 5 16595926 (2), 17161515 (1), 8113109 (1)
    cancer 37.7 68 16297569 (6), 16472112 (4), 20097177 (3), 17440054 (2) (see all 36)
    colon cancer 32.4 8 10198218 (3), 20204278 (1), 15778089 (1), 16182273 (1) (see all 6)
    alzheimers disease 29.8 5 10963362 (1), 18781276 (1), 2005999 (1), 10587643 (1) (see all 5)
    tumors 27.4 105 15514946 (7), 18331622 (6), 15380518 (5), 10752676 (3) (see all 49)
    hepatocellular carcinoma 27.2 18 20082722 (8), 20087778 (2), 12713871 (2), 19533686 (1) (see all 7)
    cell damage 26.9 5 11113529 (3), 18813861 (1)
    prostate cancer 24 34 19097122 (4), 17062670 (4), 17640713 (4), 10760948 (3) (see all 14)

    Genetic Association Database (GAD): HSPA5
    Human Genome Epidemiology (HuGE) Navigator: HSPA5 (10 documents)

    Export disorders for HSPA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA5 gene, integrated from 9 sources (see all 951):
    (articles sorted by number of sources associating them with HSPA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphism of rs430397 in the fif th intron of GRP78 gene and clinical relevance of primary hepatocellular carcin oma in Han Chinese: risk and prognosis. (PubMed id 19533686)1, 4, 9 Zhu X....Kung H.F. (2009)
    2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (2013)
    3. Lack of association between the GRP78 polymorphisms i n the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chin ese Han population. (PubMed id 20525207)1, 4 Zhu X....Kung H.F. (2010)
    4. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. (PubMed id 18502753)1, 2 Hosokawa N.... Nagata K. (2008)
    5. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2 Christianson J.C.... Kopito R.R. (2008)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    7. HSPA5 promoter polymorphisms and risk of Parkinson's disease in Taiwan. (PubMed id 18343577)1, 4 Chen C.M....Lee-Chen G.J. (2008)
    8. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    9. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    10. Functional polymorphisms of HSPA5: possible association with bipolar disorder. (PubMed id 16168956)1, 4 Kakiuchi C....Kato T. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3309 HGNC: 5238 AceView: HSPA5 Ensembl:ENSG00000044574 euGenes: HUgn3309
    ECgene: HSPA5 Kegg: 3309 H-InvDB: HSPA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA5 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA5 gene:
    Search GeneIP for patents involving HSPA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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