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Aliases for HSPA5 Gene

Aliases for HSPA5 Gene

  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) 2 3
  • Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78 3 4
  • Immunoglobulin Heavy Chain-Binding Protein 3 4
  • GRP78 3 4
  • BIP 3 4
  • Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD) 2
  • Epididymis Secretory Sperm Binding Protein Li 89n 3
  • Heat Shock 70 KDa Protein 5 4
  • HEL-S-89n 3
  • GRP-78 4
  • MIF2 3

External Ids for HSPA5 Gene

Previous HGNC Symbols for HSPA5 Gene

  • GRP78

Previous GeneCards Identifiers for HSPA5 Gene

  • GC09M119111
  • GC09M119643
  • GC09M121450
  • GC09M123373
  • GC09M125076
  • GC09M127036
  • GC09M127997
  • GC09M097610

Summaries for HSPA5 Gene

Entrez Gene Summary for HSPA5 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

GeneCards Summary for HSPA5 Gene

HSPA5 (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa)) is a Protein Coding gene. Diseases associated with HSPA5 include borna disease and wolfram syndrome. Among its related pathways are Immune System and Hemostasis. GO annotations related to this gene include calcium ion binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA5 Gene

  • Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Wiki entry for HSPA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA5 Gene

Genomics for HSPA5 Gene

Regulatory Elements for HSPA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA5 Gene

125,234,848 bp from pter
125,241,387 bp from pter
6,540 bases
Minus strand

Genomic View for HSPA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA5 Gene

Proteins for HSPA5 Gene

  • Protein details for HSPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    78 kDa glucose-regulated protein
    Protein Accession:
    Secondary Accessions:
    • B0QZ61
    • Q2EF78
    • Q9NPF1
    • Q9UK02

    Protein attributes for HSPA5 Gene

    654 amino acids
    Molecular mass:
    72333 Da
    Quaternary structure:
    • Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10 and MX1. Interacts with METTL23. Interacts with CEMIP; the interaction induces calcium leakage from the endoplamic reticulum and cell migration.

    Three dimensional structures from OCA and Proteopedia for HSPA5 Gene

neXtProt entry for HSPA5 Gene

Proteomics data for HSPA5 Gene at MOPED

Post-translational modifications for HSPA5 Gene

  • Ubiquitination at Lys 96, Lys 113, Lys 118, Lys 268, Lys 326, Lys 370, Lys 376, Lys 523, Lys 547, Lys 573, and Lys 601
  • Glycosylation at Thr 69, Thr 203, and Thr 643
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPA5 (GRP78)

No data available for DME Specific Peptides for HSPA5 Gene

Domains & Families for HSPA5 Gene

Gene Families for HSPA5 Gene

Protein Domains for HSPA5 Gene

Suggested Antigen Peptide Sequences for HSPA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA5: view

Function for HSPA5 Gene

Molecular function for HSPA5 Gene

GENATLAS Biochemistry:
glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2
UniProtKB/Swiss-Prot Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Ontology (GO) - Molecular Function for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 20477988
GO:0005509 calcium ion binding TAS 16130169
GO:0005515 protein binding IPI 11907036
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with HSPA5: view
genes like me logo Genes that share phenotypes with HSPA5: view

Animal Models for HSPA5 Gene

MGI Knock Outs for HSPA5:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HSPA5 Gene

Localization for HSPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA5 Gene

Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for HSPA5 Gene COMPARTMENTS Subcellular localization image for HSPA5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 2
golgi apparatus 2
lysosome 2
mitochondrion 2
plasma membrane 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 11943137
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HSPA5: view

Pathways & Interactions for HSPA5 Gene

genes like me logo Genes that share pathways with HSPA5: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006983 ER overload response IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response IEA --
GO:0007596 blood coagulation TAS --
GO:0021589 cerebellum structural organization IEA --
genes like me logo Genes that share ontologies with HSPA5: view

No data available for SIGNOR curated interactions for HSPA5 Gene

Drugs & Compounds for HSPA5 Gene

(47) Drugs for HSPA5 Gene - From: NovoSeek, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antihemophilic Factor Approved, Investigational Pharma Target, chaperone 0
Aspirin Approved Pharma Channel blocker, Target, binding 971
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 395
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Dopamine Approved Pharma Full agonist, Agonist 2814

(54) Additional Compounds for HSPA5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Actinomycin D
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with HSPA5: view

Transcripts for HSPA5 Gene

mRNA/cDNA for HSPA5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1367) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA5 Gene

Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA5 Gene

No ASD Table

Relevant External Links for HSPA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA5 Gene

mRNA expression in normal human tissues for HSPA5 Gene

Protein differential expression in normal tissues from HIPED for HSPA5 Gene

This gene is overexpressed in Bone marrow stromal cell (6.9) and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA5 Gene

SOURCE GeneReport for Unigene cluster for HSPA5 Gene Hs.743241

genes like me logo Genes that share expression patterns with HSPA5: view

Protein tissue co-expression partners for HSPA5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA5 Gene

Orthologs for HSPA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPA5 35
  • 94.05 (n)
  • 99.22 (a)
(Canis familiaris)
Mammalia HSPA5 35
  • 94.09 (n)
  • 99.24 (a)
HSPA5 36
  • 99 (a)
(Mus musculus)
Mammalia Hspa5 35
  • 92.35 (n)
  • 98.62 (a)
Hspa5 16
Hspa5 36
  • 98 (a)
(Pan troglodytes)
Mammalia HSPA5 35
  • 99.69 (n)
  • 100 (a)
HSPA5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hspa5 35
  • 91.03 (n)
  • 98.47 (a)
(Monodelphis domestica)
Mammalia HSPA5 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia HSPA5 36
  • 96 (a)
(Gallus gallus)
Aves HSPA5 35
  • 84.59 (n)
  • 97.64 (a)
HSPA5 36
  • 97 (a)
(Anolis carolinensis)
Reptilia HSPA5 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492570 35
  • 80.91 (n)
  • 96.06 (a)
Str.3462 35
African clawed frog
(Xenopus laevis)
Amphibia hspa5-prov 35
(Danio rerio)
Actinopterygii Dr.26116 35
hspa5 35
  • 77.55 (n)
  • 93.53 (a)
hspa5 36
  • 92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11216 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004192 35
  • 71.81 (n)
  • 82.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-3 35
  • 73.49 (n)
  • 82.52 (a)
Hsc70-3 36
  • 80 (a)
(Caenorhabditis elegans)
Secernentea hsp-3 35
  • 71.02 (n)
  • 79.69 (a)
hsp-3 36
  • 77 (a)
hsp-4 36
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR038W 35
  • 62.97 (n)
  • 65.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09559g 35
  • 64.93 (n)
  • 69.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR2 35
  • 64.59 (n)
  • 68.8 (a)
SSA2 36
  • 64 (a)
KAR2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons BIP1 35
  • 64.91 (n)
  • 70.93 (a)
(Glycine max)
eudicotyledons Gma.17631 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4801 35
(Oryza sativa)
Liliopsida Os02g0115900 35
  • 66.13 (n)
  • 71.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03982 35
  • 65.76 (n)
  • 69.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bip1 35
  • 66.83 (n)
  • 69.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
Species with no ortholog for HSPA5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA5 Gene

Gene Tree for HSPA5 (if available)
Gene Tree for HSPA5 (if available)

Paralogs for HSPA5 Gene

Paralogs for HSPA5 Gene

(14) SIMAP similar genes for HSPA5 Gene using alignment to 1 proteins: Pseudogenes for HSPA5 Gene

genes like me logo Genes that share paralogs with HSPA5: view

Variants for HSPA5 Gene

Sequence variations from dbSNP and Humsavar for HSPA5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7922 -- 125,236,454(-) CTAAG(C/T)GGCTG utr-variant-3-prime
rs8759 -- 125,236,372(-) AAAGC(A/G)GGTAA utr-variant-3-prime
rs12009 -- 125,235,024(-) CAATA(C/T)AGCCA utr-variant-3-prime
rs430397 -- 125,238,840(-) ACCAT(A/G)TCTTT intron-variant
rs1140763 -- 125,235,313(-) GAACC(C/T)GGGAG utr-variant-3-prime

Variation tolerance for HSPA5 Gene

Residual Variation Intolerance Score: 14.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSPA5 Gene

Disorders for HSPA5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HSPA5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
borna disease
  • enzootic encephalomyelitis
wolfram syndrome
  • didmoad
transient cerebral ischemia
  • transient cerebral ischaemia nos
rheumatoid arthritis
  • rheumatoid arthritis, progression of
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association
Search HSPA5 in MalaCards View complete list of genes associated with diseases


  • Note=Autoantigen in rheumatoid arthritis. {ECO:0000269 PubMed:11160188}.

Relevant External Links for HSPA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPA5: view

No data available for Genatlas for HSPA5 Gene

Publications for HSPA5 Gene

  1. Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts. (PMID: 11689471) Deng W.G. … Wu K.K. (FASEB J. 2001) 23 25 67
  2. Biosynthesis, assembly and secretion of coagulation factor VIII. (PMID: 9607108) Kaufman R.J. … Moussalli M. (Blood Coagul. Fibrinolysis 1997) 23 25 67
  3. Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. (PMID: 20038265) Kim D.S. … Chae H.J. (Immunopharmacol Immunotoxicol 2010) 23 67
  4. Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. (PMID: 20165829) Raciti G.A. … Miele C. (Diabetologia 2010) 23 67
  5. The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes. (PMID: 20183797) Zheng H.C. … Takano Y. (Histol. Histopathol. 2010) 23 67

Products for HSPA5 Gene

Sources for HSPA5 Gene

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