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Aliases for HSPA5 Gene

Aliases for HSPA5 Gene

  • Heat Shock Protein Family A (Hsp70) Member 5 2 3 5
  • Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) 2 3
  • Endoplasmic Reticulum Lumenal Ca(2+)-Binding Protein Grp78 3 4
  • Immunoglobulin Heavy Chain-Binding Protein 3 4
  • Glucose-Regulated Protein, 78kDa 2 3
  • GRP78 3 4
  • BIP 3 4
  • Heat Shock 70kD Protein 5 (Glucose-Regulated Protein, 78kD) 2
  • Epididymis Secretory Sperm Binding Protein Li 89n 3
  • 78 KDa Glucose-Regulated Protein 3
  • Heat Shock 70 KDa Protein 5 4
  • HEL-S-89n 3
  • GRP-78 4
  • MIF2 3

External Ids for HSPA5 Gene

Previous HGNC Symbols for HSPA5 Gene

  • GRP78

Previous GeneCards Identifiers for HSPA5 Gene

  • GC09M119111
  • GC09M119643
  • GC09M121450
  • GC09M123373
  • GC09M125076
  • GC09M127036
  • GC09M127997
  • GC09M097610

Summaries for HSPA5 Gene

Entrez Gene Summary for HSPA5 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

GeneCards Summary for HSPA5 Gene

HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) is a Protein Coding gene. Diseases associated with HSPA5 include Wolfram Syndrome and Borna Disease. Among its related pathways are Platelet activation, signaling and aggregation and Cellular Senescence. GO annotations related to this gene include calcium ion binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot for HSPA5 Gene

  • Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Wiki entry for HSPA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA5 Gene

Genomics for HSPA5 Gene

Regulatory Elements for HSPA5 Gene

Enhancers for HSPA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around HSPA5 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA5 Gene

Chromosome:
9
Start:
125,234,848 bp from pter
End:
125,241,387 bp from pter
Size:
6,540 bases
Orientation:
Minus strand

Genomic View for HSPA5 Gene

Genes around HSPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA5 Gene

Proteins for HSPA5 Gene

  • Protein details for HSPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11021-GRP78_HUMAN
    Recommended name:
    78 kDa glucose-regulated protein
    Protein Accession:
    P11021
    Secondary Accessions:
    • B0QZ61
    • Q2EF78
    • Q9NPF1
    • Q9UK02

    Protein attributes for HSPA5 Gene

    Size:
    654 amino acids
    Molecular mass:
    72333 Da
    Quaternary structure:
    • Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1. Interacts with DNAJC10 and MX1. Interacts with METTL23. Interacts with CEMIP; the interaction induces calcium leakage from the endoplamic reticulum and cell migration. Interacts with PCSK4 form; the interaction takes place in the endoplasmic reticulum (PubMed:21080038).

    Three dimensional structures from OCA and Proteopedia for HSPA5 Gene

neXtProt entry for HSPA5 Gene

Post-translational modifications for HSPA5 Gene

  • Ubiquitination at Lys 96, Lys 113, Lys 118, Lys 268, Lys 326, Lys 370, Lys 376, Lys 523, Lys 547, Lys 573, and Lys 601
  • Glycosylation at Thr 69, Thr 203, and Thr 643
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA5 Gene

Domains & Families for HSPA5 Gene

Gene Families for HSPA5 Gene

Protein Domains for HSPA5 Gene

Suggested Antigen Peptide Sequences for HSPA5 Gene

Graphical View of Domain Structure for InterPro Entry

P11021

UniProtKB/Swiss-Prot:

GRP78_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA5: view

Function for HSPA5 Gene

Molecular function for HSPA5 Gene

GENATLAS Biochemistry:
glucose regulated protein (78kDa),HSP70 homolog,in the endoplasmic reticulum,subunit of PPP1CC2
UniProtKB/Swiss-Prot Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Ontology (GO) - Molecular Function for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 20477988
GO:0005509 calcium ion binding TAS 16130169
GO:0005515 protein binding IEA,IPI 11907036
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity ISS --
genes like me logo Genes that share ontologies with HSPA5: view
genes like me logo Genes that share phenotypes with HSPA5: view

Animal Models for HSPA5 Gene

MGI Knock Outs for HSPA5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA5 Gene

Localization for HSPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA5 Gene

Endoplasmic reticulum lumen. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA5 Gene COMPARTMENTS Subcellular localization image for HSPA5 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
cytosol 4
mitochondrion 4
plasma membrane 3
cytoskeleton 2
golgi apparatus 2
lysosome 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 11943137
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA,TAS 16130169
GO:0005788 endoplasmic reticulum lumen IEA,TAS --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with HSPA5: view

Pathways & Interactions for HSPA5 Gene

genes like me logo Genes that share pathways with HSPA5: view

Gene Ontology (GO) - Biological Process for HSPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006983 ER overload response IEA --
GO:0006987 activation of signaling protein activity involved in unfolded protein response IEA --
GO:0021589 cerebellum structural organization IEA --
GO:0021680 cerebellar Purkinje cell layer development IEA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with HSPA5: view

No data available for SIGNOR curated interactions for HSPA5 Gene

Drugs & Compounds for HSPA5 Gene

(51) Drugs for HSPA5 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antihemophilic Factor (Recombinant) Approved, Investigational Pharma Target, chaperone 0
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, binding 1074
Platinum compounds Pharma 0

(50) Additional Compounds for HSPA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSPA5: view

Transcripts for HSPA5 Gene

mRNA/cDNA for HSPA5 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1367) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA5 Gene

Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA5 Gene

No ASD Table

Relevant External Links for HSPA5 Gene

GeneLoc Exon Structure for
HSPA5
ECgene alternative splicing isoforms for
HSPA5

Expression for HSPA5 Gene

mRNA expression in normal human tissues for HSPA5 Gene

Protein differential expression in normal tissues from HIPED for HSPA5 Gene

This gene is overexpressed in Bone marrow stromal cell (6.9) and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA5 Gene



Protein tissue co-expression partners for HSPA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA5 Gene:

HSPA5

SOURCE GeneReport for Unigene cluster for HSPA5 Gene:

Hs.743241
genes like me logo Genes that share expression patterns with HSPA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA5 Gene

Orthologs for HSPA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA5 34
  • 94.05 (n)
  • 99.22 (a)
dog
(Canis familiaris)
Mammalia HSPA5 34
  • 94.09 (n)
  • 99.24 (a)
HSPA5 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa5 34
  • 92.35 (n)
  • 98.62 (a)
Hspa5 16
Hspa5 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA5 34
  • 99.69 (n)
  • 100 (a)
HSPA5 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa5 34
  • 91.03 (n)
  • 98.47 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA5 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA5 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPA5 34
  • 84.59 (n)
  • 97.64 (a)
HSPA5 35
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA5 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492570 34
  • 80.91 (n)
  • 96.06 (a)
Str.3462 34
African clawed frog
(Xenopus laevis)
Amphibia hspa5-prov 34
zebrafish
(Danio rerio)
Actinopterygii Dr.26116 34
hspa5 34
  • 77.55 (n)
  • 93.53 (a)
hspa5 35
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11216 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004192 34
  • 71.81 (n)
  • 82.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-3 34
  • 73.49 (n)
  • 82.52 (a)
Hsc70-3 35
  • 80 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hsp-3 34
  • 71.02 (n)
  • 79.69 (a)
hsp-3 35
  • 77 (a)
OneToMany
hsp-4 35
  • 75 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR038W 34
  • 62.97 (n)
  • 65.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09559g 34
  • 64.93 (n)
  • 69.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAR2 34
  • 64.59 (n)
  • 68.8 (a)
SSA2 35
  • 64 (a)
OneToMany
KAR2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons BIP1 34
  • 64.91 (n)
  • 70.93 (a)
soybean
(Glycine max)
eudicotyledons Gma.17631 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4801 34
rice
(Oryza sativa)
Liliopsida Os02g0115900 34
  • 66.13 (n)
  • 71.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03982 34
  • 65.76 (n)
  • 69.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bip1 34
  • 66.83 (n)
  • 69.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToOne
Species where no ortholog for HSPA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA5 Gene

ENSEMBL:
Gene Tree for HSPA5 (if available)
TreeFam:
Gene Tree for HSPA5 (if available)

Paralogs for HSPA5 Gene

Paralogs for HSPA5 Gene

(14) SIMAP similar genes for HSPA5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HSPA5 Gene

genes like me logo Genes that share paralogs with HSPA5: view

Variants for HSPA5 Gene

Sequence variations from dbSNP and Humsavar for HSPA5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs35356639 - 125,236,930(+) TGGTT(A/C/G/T)ATGAT reference, missense
rs7922 -- 125,236,454(-) CTAAG(C/T)GGCTG utr-variant-3-prime
rs8759 -- 125,236,372(-) AAAGC(A/G)GGTAA utr-variant-3-prime
rs12009 -- 125,235,024(-) CAATA(C/T)AGCCA utr-variant-3-prime
rs430397 -- 125,238,840(-) ACCAT(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA5 Gene

Variant ID Type Subtype PubMed ID
nsv982345 CNV duplication 23825009

Variation tolerance for HSPA5 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA5 Gene

Human Gene Mutation Database (HGMD)
HSPA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA5 Gene

Disorders for HSPA5 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HSPA5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wolfram syndrome
  • diabetes mellitus and insipidus with optic atrophy and deafness
borna disease
  • enzootic encephalomyelitis
transient cerebral ischemia
  • tia
spinocerebellar ataxia 17
  • spinocerebellar ataxia type 17
spinocerebellar ataxia 14
  • spinocerebellar ataxia type 14
- elite association - COSMIC cancer census association via MalaCards
Search HSPA5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GRP78_HUMAN
  • Note=Autoantigen in rheumatoid arthritis. {ECO:0000269 PubMed:11160188}.

Relevant External Links for HSPA5

Genetic Association Database (GAD)
HSPA5
Human Genome Epidemiology (HuGE) Navigator
HSPA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA5
genes like me logo Genes that share disorders with HSPA5: view

No data available for Genatlas for HSPA5 Gene

Publications for HSPA5 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 65
  2. ERdj5 is the ER reductase that catalyzes the removal of non-native disulfides and correct folding of the LDL receptor. (PMID: 23769672) Oka O.B. … Bulleid N.J. (Mol. Cell 2013) 3 4 65
  3. Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration. (PMID: 23990668) Evensen N.A. … Cao J. (J. Natl. Cancer Inst. 2013) 3 4 65
  4. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 3 4 65
  5. The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone. (PMID: 21080038) Gyamera-Acheampong C. … Mbikay M. (Mol. Cell. Biochem. 2011) 3 4 65

Products for HSPA5 Gene

Sources for HSPA5 Gene

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