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Aliases for HSPA4L Gene

Aliases for HSPA4L Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 Like 2 3 5
  • Heat Shock 70-Related Protein APG-1 3 4
  • Heat Shock 70kDa Protein 4-Like 2 3
  • Osmotic Stress Protein 94 3 4
  • Osp94 3 4
  • Testis Tissue Sperm-Binding Protein Li 64n 3
  • Heat Shock 70 KDa Protein 4-Like Protein 3
  • Heat Shock Protein (Hsp110 Family) 3
  • APG-1 3
  • HSPH3 3
  • APG1 4

External Ids for HSPA4L Gene

Previous GeneCards Identifiers for HSPA4L Gene

  • GC04P129062
  • GC04P128922
  • GC04P128703
  • GC04P124431

Summaries for HSPA4L Gene

Entrez Gene Summary for HSPA4L Gene

  • The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for HSPA4L Gene

HSPA4L (Heat Shock Protein Family A (Hsp70) Member 4 Like) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. An important paralog of this gene is HSPA4.

UniProtKB/Swiss-Prot for HSPA4L Gene

  • Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.

Gene Wiki entry for HSPA4L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA4L Gene

Genomics for HSPA4L Gene

Regulatory Elements for HSPA4L Gene

Enhancers for HSPA4L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPA4L on UCSC Golden Path with GeneCards custom track

Promoters for HSPA4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA4L on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA4L Gene

127,781,821 bp from pter
127,840,733 bp from pter
58,913 bases
Plus strand

Genomic View for HSPA4L Gene

Genes around HSPA4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4L Gene

Proteins for HSPA4L Gene

  • Protein details for HSPA4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 4L
    Protein Accession:
    Secondary Accessions:
    • A2ICT2
    • Q4W5M5
    • Q8IWA2

    Protein attributes for HSPA4L Gene

    839 amino acids
    Molecular mass:
    94512 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSPA4L Gene

Proteomics data for HSPA4L Gene at MOPED

Post-translational modifications for HSPA4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA4L Gene

No data available for DME Specific Peptides for HSPA4L Gene

Domains & Families for HSPA4L Gene

Gene Families for HSPA4L Gene

Protein Domains for HSPA4L Gene

Suggested Antigen Peptide Sequences for HSPA4L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4L: view

Function for HSPA4L Gene

Molecular function for HSPA4L Gene

UniProtKB/Swiss-Prot Function:
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
UniProtKB/Swiss-Prot Induction:
By heat shock and osmotic imbalance.
genes like me logo Genes that share phenotypes with HSPA4L: view

Animal Models for HSPA4L Gene

MGI Knock Outs for HSPA4L:

Animal Model Products

CRISPR Products

miRNA for HSPA4L Gene

miRTarBase miRNAs that target HSPA4L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4L Gene

Localization for HSPA4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4L Gene

Cytoplasm. Nucleus. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for HSPA4L Gene COMPARTMENTS Subcellular localization image for HSPA4L gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
peroxisome 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for HSPA4L Gene

Pathways & Interactions for HSPA4L Gene

genes like me logo Genes that share pathways with HSPA4L: view

Pathways by source for HSPA4L Gene

Gene Ontology (GO) - Biological Process for HSPA4L Gene


No data available for SIGNOR curated interactions for HSPA4L Gene

Drugs & Compounds for HSPA4L Gene

(1) Drugs for HSPA4L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HSPA4L: view

Transcripts for HSPA4L Gene

Unigene Clusters for HSPA4L Gene

Heat shock 70kDa protein 4-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: -

Relevant External Links for HSPA4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA4L Gene

mRNA expression in normal human tissues for HSPA4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA4L Gene

This gene is overexpressed in Testis (x9.2).

Protein differential expression in normal tissues from HIPED for HSPA4L Gene

This gene is overexpressed in Brain (9.5), Cervix (9.2), Frontal cortex (8.8), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPA4L Gene

SOURCE GeneReport for Unigene cluster for HSPA4L Gene Hs.135554

genes like me logo Genes that share expression patterns with HSPA4L: view

Protein tissue co-expression partners for HSPA4L Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HSPA4L Gene

Orthologs for HSPA4L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPA4L 35
  • 93.25 (n)
  • 94.74 (a)
  • 91 (a)
(Canis familiaris)
Mammalia HSPA4L 35
  • 94.28 (n)
  • 95.95 (a)
  • 83 (a)
(Mus musculus)
Mammalia Hspa4l 35
  • 88.33 (n)
  • 92.71 (a)
Hspa4l 16
Hspa4l 36
  • 93 (a)
(Pan troglodytes)
Mammalia HSPA4L 35
  • 99.6 (n)
  • 99.28 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Hspa4l 35
  • 88.89 (n)
  • 93.07 (a)
(Monodelphis domestica)
Mammalia HSPA4L 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves HSPA4L 35
  • 78.67 (n)
  • 81.88 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia HSPA4L 36
  • 78 (a)
(Danio rerio)
Actinopterygii si:dkey-21a6.6 35
  • 66.67 (n)
  • 67.97 (a)
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea hsp-110 36
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 36
  • 37 (a)
SSE2 36
  • 37 (a)
(Zea mays)
Liliopsida Zm.4273 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1750 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 36
  • 46 (a)
Species with no ortholog for HSPA4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA4L Gene

Gene Tree for HSPA4L (if available)
Gene Tree for HSPA4L (if available)

Paralogs for HSPA4L Gene

Paralogs for HSPA4L Gene

genes like me logo Genes that share paralogs with HSPA4L: view

Variants for HSPA4L Gene

Sequence variations from dbSNP and Humsavar for HSPA4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1380154 - 127,801,887(+) GGTCT(C/T)GGTTT reference, missense
rs12507229 - 127,801,902(+) TTTTA(A/C)CAAAG reference, missense
rs35518193 - 127,820,555(-) TTTCA(A/G)TGTAG reference, missense
rs1459050 -- 127,789,050(-) CTCAG(C/T)ACTAA intron-variant
rs1380155 -- 127,806,663(+) TGCCC(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA4L Gene

Variant ID Type Subtype PubMed ID
nsv879915 CNV Gain 21882294
dgv5711n71 CNV Loss 21882294
nsv879921 CNV Loss 21882294
nsv879923 CNV Loss 21882294
nsv830057 CNV Loss 17160897
dgv5713n71 CNV Loss 21882294
nsv437935 CNV Loss 16468122
nsv879928 CNV Loss 21882294
esv2728291 CNV Deletion 23290073
esv2669954 CNV Deletion 23128226

Variation tolerance for HSPA4L Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSPA4L Gene

Disorders for HSPA4L Gene

Relevant External Links for HSPA4L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HSPA4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA4L Gene

Publications for HSPA4L Gene

  1. Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. (PMID: 10524232) Nonoguchi K. … Fujita J. (Gene 1999) 2 3 4 23 67
  2. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. (PMID: 19169850) Mala J.G. … Takeuchi S. (Mol. Biotechnol. 2009) 3 23
  3. Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm. (PMID: 11389747) Nonoguchi K. … Fujita J. (Int. J. Urol. 2001) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HSPA4L Gene

Sources for HSPA4L Gene