Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HSPA4L Gene

protein-coding   GIFtS: 55
GCID: GC04P128703

Heat Shock 70kDa Protein 4-Like

  See HSPA4L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Heat Shock 70kDa Protein 4-Like1 2     Heat Shock 70 KDa Protein 4-Like Protein2
Heat Shock 70-Related Protein APG-12 3     Heat Shock 70 KDa Protein 4L2
Osmotic Stress Protein 942 3     Heat Shock Protein (Hsp110 Family)2
APG-12     APG13
HSPH32     OSP943
Osp942     

External Ids:    HGNC: 170411   Entrez Gene: 228242   Ensembl: ENSG000001640707   UniProtKB: O957573   

Export aliases for HSPA4L gene to outside databases

Previous GC identifers: GC04P129062 GC04P128922 GC04P124431


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for HSPA4L Gene:
HSPA4L (heat shock 70kDa protein 4-like) is a protein-coding gene. Diseases associated with HSPA4L include endolymphatic hydrops. An important paralog of this gene is HYOU1.

UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757
Function: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity)

Gene Wiki entry for HSPA4L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA4L gene promoter:
         HFH-3   C/EBPbeta   AP-1   ATF-2   GATA-1   Evi-1   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA4L promoter sequence
   Search Chromatin IP Primers for HSPA4L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28

HSPA4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P128703:  view genomic region     (about GC identifiers)

Start:
128,702,976 bp from pter      End:
128,761,888 bp from pter
Size:
58,913 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 4L  
Size: 839 amino acids; 94512 Da
Subunit: Homodimer (By similarity)
Secondary accessions: A2ICT2 Q4W5M5 Q8IWA2

Explore the universe of human proteins at neXtProt for HSPA4L: NX_O95757

Explore proteomics data for HSPA4L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys388
  • Modification sites at PhosphoSitePlus

  • See HSPA4L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055093.2  
    ENSEMBL proteins: 
     ENSP00000422482   ENSP00000296464   ENSP00000427305   ENSP00000425645   ENSP00000393926  

    HSPA4L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HSPA4L
    GenScript Custom Purified and Recombinant Proteins Services for HSPA4L
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA4L

     
    Search eBioscience for Proteins for HSPA4L 

     
    Search antibodies-online for proteins for HSPA4L 

     
    antibodies-online peptides for HSPA4L

    HSPA4L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HSPA4L
    OriGene Custom Antibody Services for HSPA4L
    Novus Biologicals HSPA4L Antibodies
    Abcam antibodies for HSPA4L
    Cloud-Clone Corp. Antibodies for HSPA4L
    Search ThermoFisher Antibodies for HSPA4L
    antibodies-online antibodies for HSPA4L (22 products) 

    HSPA4L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSPA4L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPA4L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPA4L
    Cloud-Clone Corp. CLIAs for HSPA4L
    Search eBioscience for ELISAs for HSPA4L 
    antibodies-online kits for HSPA4L (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry O95757

    ProtoNet protein and cluster: O95757

    UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA4L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS74L_HUMAN, O95757
    Function: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity)
    Induction: By heat shock and osmotic imbalance

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding ISS--
         
    Find genes that share ontologies with HSPA4L           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hspa4l):
     growth/size/body  homeostasis/metabolism  mortality/aging  renal/urinary system  reproductive system 

    Find genes that share phenotypes with HSPA4L           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hspa4ltm1Imad for HSPA4L

       genOway: Develop your customized and physiologically relevant rodent model for HSPA4L

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA4L:
    hsa-mir-155-5p (MIRT020685), hsa-mir-16-5p (MIRT031642)

    Block miRNA regulation of human, mouse, rat HSPA4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA4L (see all 21):
    hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-606 hsa-miR-424 hsa-miR-501-5p hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPA4L
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA4L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA4L

    Clone
    Products:
         
    OriGene clones in human, mouse for HSPA4L (see all 6)
    OriGene ORF clones in mouse, rat for HSPA4L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA4L (NM_014278)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4L
    Addgene plasmids for HSPA4L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSPA4L
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA4L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HS74L_HUMAN, O95757: Cytoplasm (By similarity). Nucleus (By similarity). Note=May translocate to the nucleus
    after heat shock (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with HSPA4L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HSPA4L About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with HSPA4L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for HSPA4L):
        Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA4L: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HSPA4L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA4L (O957572, 3 ENSP000002964644) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3MINT-49171 I2D: score=2 
    USF2Q158533, ENSP000002223054I2D: score=2 STRING: ENSP00000222305
    PHLDA1Q8WV243, ENSP000002666714I2D: score=1 STRING: ENSP00000266671
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    TIMP2P160353, ENSP000002627684I2D: score=1 STRING: ENSP00000262768
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006457protein folding ISS--
    GO:0006986response to unfolded protein ISS--

    Find genes that share ontologies with HSPA4L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA4L (HS74L)

    1 Novoseek inferred chemical compound relationship for HSPA4L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urea 42.5 1 10919839 (1)



    Find genes that share compounds with HSPA4L           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HSPA4L gene: 
    NM_014278.2  

    Unigene Cluster for HSPA4L:

    Heat shock 70kDa protein 4-like
    Hs.135554  [show with all ESTs]
    Unigene Representative Sequence: NM_014278
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508776 ENST00000296464(uc010iny.1 uc003ifm.3 uc011cgr.2)
    ENST00000508549 ENST00000505726 ENST00000515262 ENST00000439123
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSPA4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA4L (see all 21):
    hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-606 hsa-miR-424 hsa-miR-501-5p hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSPA4L
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA4L
    Clone
    Products:
         
    OriGene clones in human, mouse for HSPA4L (see all 6)
    OriGene ORF clones in mouse, rat for HSPA4L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA4L (NM_014278)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4L
    Addgene plasmids for HSPA4L 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPA4L
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA4L
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA4L
      QuantiFast Probe-based Assays in human, mouse, rat HSPA4L

    Additional mRNA sequence: 

    AB023421.1 AK027822.1 AK302115.1 AK303053.1 AK307464.1 AY290862.1 BC040560.1 EF197155.1 

    11 DOTS entries:

    DT.212725  DT.100750004  DT.97814538  DT.430090  DT.91858508  DT.100720837  DT.121265262  DT.91798519 
    DT.92420013  DT.100744803  DT.40198389 

    Selected AceView cDNA sequences (see all 76):

    BM982947 BM722510 BM679019 NM_014278 BX645314 AI478380 AI917699 BX119807 
    AA149534 AA402062 BM704107 AI077291 BC040560 CB130195 AA364471 AI732977 
    AA398923 BP360751 CA311442 BX953590 AA451968 BI333973 AA421206 AA975783 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                      -                                                   
    SP2:                          -                                                                                                               
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for HSPA4L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HSPA4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGGCTGA
    HSPA4L Expression
    About this image


    HSPA4L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Brain (Nervous System)
             Cerebellum
    HSPA4L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA4L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.135554
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA4L: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPA4L
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA4L
    QuantiTect SYBR Green Assays in human, mouse, rat HSPA4L
    QuantiFast Probe-based Assays in human, mouse, rat HSPA4L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA4L gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa4l1 , 5 heat shock protein 4 like1, 5 88.33(n)1
    92.71(a)1
      3 (19.51 cM)5
    184151  NM_011020.31  NP_035150.31 
     407444955 
    chicken
    (Gallus gallus)
    Aves HSPA4L1 heat shock 70kDa protein 4-like 78.67(n)
    81.88(a)
      422496  NM_001012576.1  NP_001012594.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA4L6
    heat shock 70kDa protein 4-like
    78(a)
    1 ↔ 1
    5(136413442-136443493)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-21a6.61 si:dkey-21a6.6 66.67(n)
    67.97(a)
      562019  XM_685413.5  XP_690505.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70Cb6
    Hsc70Cb
    43(a)
    1 → many
    3L(14030119-14036786)
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-1106
    Protein C30C11.4 (C30C11.4) mRNA, complete cds
    45(a)
    1 → many
    III(8443917-8446920) WBGene00016250
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSE26
    SSE16
    Member of the heat shock protein 70 (HSP70) family...
    ATPase that is a component of the heat shock prote...
    37(a)
    37(a)
    many ↔ many
    many ↔ many
    II(573915-575996) YBR169C
    XVI(350194-352275) YPL106C
    corn
    (Zea mays)
    Liliopsida Zm.42732 Zea mays PCO080983 mRNA sequence 76.17(n)    AY103680.1 


    ENSEMBL Gene Tree for HSPA4L (if available)
    TreeFam Gene Tree for HSPA4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HSPA4L gene
    HYOU12  HSPH12  HSPA42  
    16 SIMAP similar genes for HSPA4L using alignment to 4 protein entries:     HS74L_HUMAN (see all proteins):
    HS24/p52    HS24/P52    HSPA4    HSPH1    HSP70-1    HSPA7
    LOC401308    HSPA1A    HSPA1B    HSPA8    HSPA1L    HSPA9
    HSPA2    HSPA6    HSPA14    HYOU1

    Find genes that share paralogs with HSPA4L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HSPA4L (see all 888)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792874191,2
    F--128701458(+) TAGGCA/CTATTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1386975181,2
    --128701513(+) AACTTC/GCCAAA 1 -- us2k10--------
    rs114498271,2
    C--128701713(+) AAAAAA/-CATTC 1 -- us2k1 trp33Minor allele frequency- -:0.17NA CSA 6
    rs2013133931,2
    C--128701713(-) TTTTTC/TCTATT 1 -- us2k10--------
    rs1492708931,2
    --128702067(+) AATGTA/GGAGAC 1 -- us2k10--------
    rs1893300061,2
    --128702127(+) AAAATG/TGATTT 1 -- us2k10--------
    rs1445175111,2
    --128702212(+) TAAAAA/TATCTA 1 -- us2k10--------
    rs1811855821,2
    --128702445(+) TAAAAC/GTGAAC 1 -- us2k10--------
    rs38411041,2
    C--128702473(-) TTAAG-/AAATTTGG 1 -- us2k10--------
    rs1854795471,2
    --128702480(+) TCTTAA/GGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSPA4L (128702976 - 128761888 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HSPA4L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669954CNV Deletion23128226
    esv2728291CNV Deletion23290073
    nsv879923CNV Loss21882294
    nsv437935CNV Loss16468122
    nsv879928CNV Loss21882294
    nsv830057CNV Loss17160897
    dgv5713n71CNV Loss21882294
    dgv5711n71CNV Loss21882294
    nsv879921CNV Loss21882294
    nsv879915CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA4L
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA4L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for HSPA4L:    
    About MalaCards
    endolymphatic hydrops

    1 disease from the University of Copenhagen DISEASES database for HSPA4L:
    Endolymphatic hydrops

    Find genes that share disorders with HSPA4L           About GenesLikeMe

    1 Novoseek inferred disease relationship for HSPA4L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 58.6 4 9161406 (1), 10524232 (1), 11389747 (1)

    Genetic Association Database (GAD): HSPA4L
    Human Genome Epidemiology (HuGE) Navigator: HSPA4L (1 document)

    Export disorders for HSPA4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HSPA4L gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with HSPA4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. (PubMed id 10524232)1, 2, 3, 9 Nonoguchi K.... Fujita J. (Gene 1999)
    2. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. (PubMed id 19169850)1, 2, 9 Mala J.G. and Takeuchi S. (Mol. Biotechnol. 2009)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm. (PubMed id 11389747)1, 9 Nonoguchi K....Fujita J. (Int. J. Urol. 2001)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110. (PubMed id 24091676)1 Kuo Y....Wang T. (amp 2013)
    10. Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. (PubMed id 23509252)1 Song Y....Brady S.T. (Proc. Natl. Acad. Sci. U.S.A. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22824 HGNC: 17041 AceView: APG-1 Ensembl:ENSG00000164070 euGenes: HUgn22824
    ECgene: HSPA4L Kegg: 22824 H-InvDB: HSPA4L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HSPA4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HSPA4L gene:
    Search GeneIP for patents involving HSPA4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HSPA4L   OriGene RNAi products in human, mouse, rat for HSPA4L  
     OriGene qPCR primer pairs and template standards for HSPA4L   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HSPA4L  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4L   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HSPA4L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPA4L   OriGene Custom Protein Services for HSPA4L  

     
     
     Block miRNA regulation of human, mouse, rat HSPA4L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HSPA4L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA4L Predesigned siRNA for gene silencing in human, mouse, rat HSPA4L
     QuantiFast Probe-based Assays in human, mouse, rat HSPA4L QuantiTect SYBR Green Assays in human, mouse, rat HSPA4L
     PCR Arrays including human, mouse, rat HSPA4L Search Chromatin IP Primers for HSPA4L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA4L  Search GeneGlobe Interaction Network for HSPA4L
     Regulatory tfbs in HSPA4L promoter
     GenScript Custom Purified and Recombinant Proteins Services for HSPA4L GenScript cDNA clones with any tag delivered in your preferred vector for HSPA4L
     GenScript Custom Assay Services for HSPA4L GenScript Custom overexpressing Cell Line Services for HSPA4L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HSPA4L (HS74L)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HSPA4L antibodies
     Antibodies for HSPA4L
     See all of Abcam's Antibodies, Kits and Proteins for HSPA4L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HSPA4L
     Antibodies for HSPA4L
     ELISAs for HSPA4L
     CLIAs for HSPA4L



     Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA4L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4L
     SwitchGear 3'UTR luciferase reporter plasmids for HSPA4L
     SwitchGear Promoter luciferase reporter plasmids for HSPA4L
     Search ThermoFisher Antibodies for HSPA4L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4L
     Browse compounds at ApexBio
     Addgene plasmids for HSPA4L
      Search eBioscience for proteins for HSPA4L
      Search eBioscience for elisas for HSPA4L
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HSPA4L
     antibodies-online antibodies for HSPA4L (22 products)
     antibodies-online kits for HSPA4L (6 products)
     antibodies-online peptides for HSPA4L
      Search antibodies-online for proteins for HSPA4L
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSPA4L gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4