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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA4L Gene

protein-coding   GIFtS: 54
GCID: GC04P128703

Heat Shock 70kDa Protein 4-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 4-Like1 2     Heat Shock 70 KDa Protein 4-Like Protein2
Heat Shock 70-Related Protein APG-12 3     Heat Shock 70 KDa Protein 4L2
Osmotic Stress Protein 942 3     Heat Shock Protein (Hsp110 Family)2
APG-12     APG13
HSPH32     OSP943
Osp942     

External Ids:    HGNC: 170411   Entrez Gene: 228242   Ensembl: ENSG000001640707   UniProtKB: O957573   

Export aliases for HSPA4L gene to outside databases

Previous GC identifers: GC04P129062 GC04P128922 GC04P124431


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPA4L Gene: 
HSPA4L (heat shock 70kDa protein 4-like) is a protein-coding gene. Diseases associated with HSPA4L include endolymphatic hydrops, and hypertension. GO annotations related to this gene include ATP binding. An important paralog of this gene is HYOU1.

UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757
Function: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity)

Gene Wiki entry for HSPA4L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA4L gene promoter:
         HFH-3   C/EBPbeta   AP-1   ATF-2   GATA-1   Evi-1   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA4L promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA4L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q28

HSPA4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P128703:  view genomic region     (about GC identifiers)

Start:
128,702,976 bp from pter      End:
128,755,226 bp from pter
Size:
52,251 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 4L  
Size: 839 amino acids; 94512 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=May translocate to the nucleus
after heat shock (By similarity)
Secondary accessions: A2ICT2 Q4W5M5 Q8IWA2

Explore the universe of human proteins at neXtProt for HSPA4L: NX_O95757

Explore proteomics data for HSPA4L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95757

  • HSPA4L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA4L Protein Expression
    REFSEQ proteins: NP_055093.2  
    ENSEMBL proteins: 
     ENSP00000422482   ENSP00000296464   ENSP00000427305   ENSP00000425645   ENSP00000393926  

    Human Recombinant Protein Products for HSPA4L: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA4L 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--

    HSPA4L for ontologies           About GeneDecksing



    HSPA4L Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HSPA4L 

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    Cloud-Clone Corp. ELISAs for HSPA4L 
    Cloud-Clone Corp. CLIAs for HSPA4L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry O95757

    ProtoNet protein and cluster: O95757

    UniProtKB/Swiss-Prot: HS74L_HUMAN, O95757
    Similarity: Belongs to the heat shock protein 70 family


    HSPA4L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS74L_HUMAN, O95757
    Function: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity)
    Induction: By heat shock and osmotic imbalance

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding ISS--
         
    HSPA4L for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hspa4l):
     growth/size  homeostasis/metabolism  mortality/aging  renal/urinary system  reproductive system 

    HSPA4L for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hspa4ltm1Imad for HSPA4L

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA4L 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPA4L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA4L 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA4L 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA4L
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA4L (see all 21):
    hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-606 hsa-miR-424 hsa-miR-501-5p hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4L 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of HSPA4L 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4L


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA4L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for HSPA4L):
        Protein processing in endoplasmic reticulum


    HSPA4L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPA4L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/38 Interacting proteins for HSPA4L (O957572, 3 ENSP000002964644) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3MINT-49171 I2D: score=2 
    PHLDA1Q8WV243, ENSP000002666714I2D: score=1 STRING: ENSP00000266671
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    KRT8P057873, ENSP000002933084I2D: score=2 STRING: ENSP00000293308
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006457protein folding ISS--
    GO:0006986response to unfolded protein ISS--

    HSPA4L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPA4L for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA4L (HS74L)

    1 Novoseek inferred chemical compound relationship for HSPA4L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urea 42.5 1 10919839 (1)

    Search CenterWatch for drugs/clinical trials and news about HSPA4L / HS74L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA4L gene: 
    NM_014278.2  

    Unigene Cluster for HSPA4L:

    Heat shock 70kDa protein 4-like
    Hs.135554  [show with all ESTs]
    Unigene Representative Sequence: NM_014278
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508776 ENST00000296464(uc010iny.1 uc003ifm.3 uc011cgr.2)
    ENST00000508549 ENST00000505726 ENST00000515262 ENST00000439123
    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA4L (see all 21):
    hsa-miR-607 hsa-miR-148b hsa-miR-15a hsa-miR-606 hsa-miR-424 hsa-miR-501-5p hsa-miR-1323 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4L 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSPA4L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA4L
    Clone
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    OriGene clones in human, mouse for HSPA4L (see all 5)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4L
    Sirion Biotech Customized lentivirus for stable overexpression of HSPA4L 
                         Customized lentivirus expression plasmids for stable overexpression of HSPA4L 
    Primer
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    OriGene qPCR primer pairs and template standards for HSPA4L
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA4L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA4L

    Additional mRNA sequence: 

    AB023421.1 AK027822.1 AK302115.1 AK303053.1 AK307464.1 AY290862.1 BC040560.1 EF197155.1 

    11 DOTS entries:

    DT.212725  DT.100750004  DT.97814538  DT.430090  DT.91858508  DT.100720837  DT.121265262  DT.91798519 
    DT.92420013  DT.100744803  DT.40198389 

    24/76 AceView cDNA sequences (see all 76):

    BM982947 CA311442 BP360751 AA398923 AI732977 AA364471 CB130195 BC040560 
    AI077291 BM704107 AA402062 AA149534 BX119807 AI917699 AI478380 BX645314 
    NM_014278 BM679019 BM722510 BX953590 BG718146 AI337285 AA431598 AK027822 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                                                                      -                                                   
    SP2:                          -                                                                                                               
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for HSPA4L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA4L expression in normal human tissues (normalized intensities)      HSPA4L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGGCTGA
    HSPA4L Expression
    About this image


    HSPA4L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             sensory organ/nose/nasal cavity   
     
     Neural Crest (Sensory Organs)
             sensory organ/nose/vomeronasal organ   
     
     Thymus (Hematopoietic System)
             Thymus

    See HSPA4L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA4L

    SOURCE GeneReport for Unigene cluster: Hs.135554
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA4L: 
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Osmotic Stress in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA4L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA4L gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa4l1 , 5 heat shock protein 4 like1, 5 88.33(n)1
    92.71(a)1
      3 (19.51 cM)5
    184151  NM_011020.31  NP_035150.31 
     407444955 
    chicken
    (Gallus gallus)
    Aves HSPA4L1 heat shock 70kDa protein 4-like 78.74(n)
    81.88(a)
      422496  NM_001012576.1  NP_001012594.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA4L6
    Uncharacterized protein
    79(a)
    1 ↔ 1
    5(136413442-136443493)
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fc07b101 wu:fc07b10 66.54(n)
    67.84(a)
      562019  XM_685413.4  XP_690505.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70Cb6
    Hsc70Cb
    44(a)
    1 → many
    3L(14030119-14036786)
    worm
    (Caenorhabditis elegans)
    Secernentea C30C11.46
    Uncharacterized protein C30C11.4
    45(a)
    1 → many
    III(8443917-8446920)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSE16
    SSE26
    ATPase that is a component of the heat shock prote...
    Member of the heat shock protein 70 (HSP70) family...
    37(a)
    36(a)
    many ↔ many
    many ↔ many
    XVI(350194-352275)
    II(573915-575996)
    corn
    (Zea mays)
    Liliopsida Zm.42732 Zea mays PCO080983 mRNA sequence 76.17(n)    AY103680.1 


    ENSEMBL Gene Tree for HSPA4L (if available)
    TreeFam Gene Tree for HSPA4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA4L gene
    HYOU12  HSPH12  HSPA42  
    16 SIMAP similar genes for HSPA4L using alignment to 4 protein entries:     HS74L_HUMAN (see all proteins):
    HS24/p52    HS24/P52    HSPA4    HSPH1    HSP70-1    HSPA7
    LOC401308    HSPA1A    HSPA1B    HSPA8    HSPA1L    HSPA9
    HSPA2    HSPA6    HSPA14    HYOU1

    HSPA4L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/888 SNPs in HSPA4L are shown (see all 888)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792874191,2
    F--128701458(+) TAGGCA/CTATTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1386975181,2
    --128701513(+) AACTTC/GCCAAA 1 -- us2k10--------
    rs114498271,2
    C--128701713(+) AAAAAA/-CATTC 1 -- us2k1 trp33Minor allele frequency- -:0.17NA CSA 6
    rs2013133931,2
    C--128701713(-) TTTTTC/TCTATT 1 -- us2k10--------
    rs1492708931,2
    --128702067(+) AATGTA/GGAGAC 1 -- us2k10--------
    rs1893300061,2
    --128702127(+) AAAATG/TGATTT 1 -- us2k10--------
    rs1445175111,2
    --128702212(+) TAAAAA/TATCTA 1 -- us2k10--------
    rs1811855821,2
    --128702445(+) TAAAAC/GTGAAC 1 -- us2k10--------
    rs38411041,2
    C--128702473(-) TTAAG-/AAATTTGG 1 -- us2k10--------
    rs1854795471,2
    --128702480(+) TCTTAA/GGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSPA4L (128702976 - 128755226 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HSPA4L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669954CNV Deletion23128226
    esv2728291CNV Deletion23290073
    nsv879923CNV Loss21882294
    nsv437935CNV Loss16468122
    nsv879928CNV Loss21882294
    nsv830057CNV Loss17160897
    dgv5713n71CNV Loss21882294
    dgv5711n71CNV Loss21882294
    nsv879921CNV Loss21882294
    nsv879915CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for HSPA4L:    About MalaCards
    endolymphatic hydrops    hypertension

    1 disease from the University of Copenhagen DISEASES database for HSPA4L:
    Endolymphatic hydrops

    HSPA4L for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HSPA4L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 58.6 4 9161406 (1), 10524232 (1), 11389747 (1)

    Genetic Association Database (GAD): HSPA4L
    Human Genome Epidemiology (HuGE) Navigator: HSPA4L (1 document)

    Export disorders for HSPA4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA4L gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with HSPA4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. (PubMed id 10524232)1, 2, 3, 9 Nonoguchi K.... Fujita J. (1999)
    2. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. (PubMed id 19169850)1, 2, 9 Mala J.G. and Takeuchi S. (2009)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Expression of Apg-1, a member of the Hsp110 family, in the human testis and sperm. (PubMed id 11389747)1, 9 Nonoguchi K....Fujita J. (2001)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    9. Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm. (PubMed id 23509252)1 Song Y....Brady S.T. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22824 HGNC: 17041 AceView: APG-1 Ensembl:ENSG00000164070 euGenes: HUgn22824
    ECgene: HSPA4L Kegg: 22824 H-InvDB: HSPA4L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA4L gene:
    Search GeneIP for patents involving HSPA4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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