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Aliases for HSPA4L Gene

Aliases for HSPA4L Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 Like 2 3 5
  • Heat Shock 70-Related Protein APG-1 3 4
  • Heat Shock 70kDa Protein 4-Like 2 3
  • Osmotic Stress Protein 94 3 4
  • Osp94 3 4
  • Testis Tissue Sperm-Binding Protein Li 64n 3
  • Heat Shock 70 KDa Protein 4-Like Protein 3
  • Heat Shock Protein (Hsp110 Family) 3
  • Heat Shock 70 KDa Protein 4L 3
  • APG-1 3
  • HSPH3 3
  • APG1 4

External Ids for HSPA4L Gene

Previous GeneCards Identifiers for HSPA4L Gene

  • GC04P129062
  • GC04P128922
  • GC04P128703
  • GC04P124431

Summaries for HSPA4L Gene

Entrez Gene Summary for HSPA4L Gene

  • The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for HSPA4L Gene

HSPA4L (Heat Shock Protein Family A (Hsp70) Member 4 Like) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. An important paralog of this gene is HSPA4.

UniProtKB/Swiss-Prot for HSPA4L Gene

  • Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.

Gene Wiki entry for HSPA4L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA4L Gene

Genomics for HSPA4L Gene

Regulatory Elements for HSPA4L Gene

Enhancers for HSPA4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F127781 1.1 ENCODE 9.8 +1.4 1398 4.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 REST TBX21 SMARCB1 ZNF610 SLC25A31 INTU HSPA4L ABHD18 ENSG00000282855
GH04F127879 1.1 ENCODE 8 +99.0 99040 2.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 ZNF207 MFSD8 HSPA4L ABHD18 PLK4 ENSG00000261668
GH04F128059 1.1 ENCODE 5.8 +279.7 279701 3.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 HSPA4L INTU ABHD18 LARP1B RPL15P8
GH04F128159 1.1 Ensembl ENCODE 5.4 +380.2 380163 5.8 ELF3 BCOR CTCF ZNF146 SAP130 JUN ZMYM3 RAD21 RARA ZNF316 HSPA4L INTU PGRMC2 FOSL1P1
GH04F128191 1 Ensembl ENCODE 5.1 +409.8 409780 0.8 HDGF CTCF PKNOX1 ZNF2 RAD21 ZNF143 SMC3 CHD2 ZNF263 MAZ HSPA4L FOSL1P1 PGRMC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA4L on UCSC Golden Path with GeneCards custom track

Promoters for HSPA4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001435115 1379 3600 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 REST TBX21 SMARCB1 ZNF610

Genomic Location for HSPA4L Gene

Chromosome:
4
Start:
127,781,821 bp from pter
End:
127,840,733 bp from pter
Size:
58,913 bases
Orientation:
Plus strand

Genomic View for HSPA4L Gene

Genes around HSPA4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4L Gene

Proteins for HSPA4L Gene

  • Protein details for HSPA4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95757-HS74L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 4L
    Protein Accession:
    O95757
    Secondary Accessions:
    • A2ICT2
    • Q4W5M5
    • Q8IWA2

    Protein attributes for HSPA4L Gene

    Size:
    839 amino acids
    Molecular mass:
    94512 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSPA4L Gene

Post-translational modifications for HSPA4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA4L Gene

Antibody Products

  • Abcam antibodies for HSPA4L

No data available for DME Specific Peptides for HSPA4L Gene

Domains & Families for HSPA4L Gene

Gene Families for HSPA4L Gene

Protein Domains for HSPA4L Gene

Suggested Antigen Peptide Sequences for HSPA4L Gene

Graphical View of Domain Structure for InterPro Entry

O95757

UniProtKB/Swiss-Prot:

HS74L_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4L: view

Function for HSPA4L Gene

Molecular function for HSPA4L Gene

UniProtKB/Swiss-Prot Function:
Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
UniProtKB/Swiss-Prot Induction:
By heat shock and osmotic imbalance.

Gene Ontology (GO) - Molecular Function for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA,ISS --
genes like me logo Genes that share ontologies with HSPA4L: view
genes like me logo Genes that share phenotypes with HSPA4L: view

Animal Models for HSPA4L Gene

MGI Knock Outs for HSPA4L:

Animal Model Products

miRNA for HSPA4L Gene

miRTarBase miRNAs that target HSPA4L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4L Gene

Localization for HSPA4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4L Gene

Cytoplasm. Nucleus. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA4L gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with HSPA4L: view

Pathways & Interactions for HSPA4L Gene

genes like me logo Genes that share pathways with HSPA4L: view

Pathways by source for HSPA4L Gene

Gene Ontology (GO) - Biological Process for HSPA4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding ISS --
GO:0006986 response to unfolded protein ISS --
genes like me logo Genes that share ontologies with HSPA4L: view

No data available for SIGNOR curated interactions for HSPA4L Gene

Drugs & Compounds for HSPA4L Gene

(1) Drugs for HSPA4L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HSPA4L: view

Transcripts for HSPA4L Gene

Unigene Clusters for HSPA4L Gene

Heat shock 70kDa protein 4-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: -
SP3:

Relevant External Links for HSPA4L Gene

GeneLoc Exon Structure for
HSPA4L
ECgene alternative splicing isoforms for
HSPA4L

Expression for HSPA4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA4L Gene

This gene is overexpressed in Testis (x9.2).

Protein differential expression in normal tissues from HIPED for HSPA4L Gene

This gene is overexpressed in Brain (9.5), Cervix (9.2), Frontal cortex (8.8), and Retina (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPA4L Gene



Protein tissue co-expression partners for HSPA4L Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA4L Gene:

HSPA4L

SOURCE GeneReport for Unigene cluster for HSPA4L Gene:

Hs.135554
genes like me logo Genes that share expression patterns with HSPA4L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HSPA4L Gene

Orthologs for HSPA4L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA4L 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia HSPA4L 34 35
  • 94.28 (n)
cow
(Bos Taurus)
Mammalia HSPA4L 34 35
  • 93.25 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA4L 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa4l 34
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Hspa4l 34 16 35
  • 88.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves HSPA4L 34 35
  • 78.67 (n)
lizard
(Anolis carolinensis)
Reptilia HSPA4L 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii HSPA4L 35
  • 67 (a)
OneToOne
si:dkey-21a6.6 34
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 35
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hsp-110 35
  • 45 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 35
  • 37 (a)
ManyToMany
SSE2 35
  • 37 (a)
ManyToMany
corn
(Zea mays)
Liliopsida Zm.4273 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 35
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1750 34
Species where no ortholog for HSPA4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA4L Gene

ENSEMBL:
Gene Tree for HSPA4L (if available)
TreeFam:
Gene Tree for HSPA4L (if available)

Paralogs for HSPA4L Gene

Paralogs for HSPA4L Gene

genes like me logo Genes that share paralogs with HSPA4L: view

Variants for HSPA4L Gene

Sequence variations from dbSNP and Humsavar for HSPA4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10493145 -- 127,797,921(+) CCTCC(A/G)AAAGT intron-variant
rs10493146 -- 127,797,984(+) ATGCA(C/T)CCCTG intron-variant
rs10493147 -- 127,816,344(+) GTTTA(C/T)TACCA intron-variant
rs10493148 -- 127,830,446(+) CCTTT(C/T)TAAAC intron-variant
rs11098938 -- 127,803,077(+) TGTTA(A/C)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA4L Gene

Variant ID Type Subtype PubMed ID
dgv199n111 CNV duplication 26073780
esv2669954 CNV deletion 23128226
esv2728291 CNV deletion 23290073
esv3602152 CNV loss 21293372
nsv1161147 CNV duplication 26073780
nsv437935 CNV loss 16468122
nsv830057 CNV loss 17160897
nsv980256 CNV duplication 23825009

Variation tolerance for HSPA4L Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA4L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA4L Gene

Disorders for HSPA4L Gene

Relevant External Links for HSPA4L

Genetic Association Database (GAD)
HSPA4L
Human Genome Epidemiology (HuGE) Navigator
HSPA4L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA4L

No disorders were found for HSPA4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA4L Gene

Publications for HSPA4L Gene

  1. Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes. (PMID: 10524232) Nonoguchi K. … Fujita J. (Gene 1999) 2 3 4 22 64
  2. Molecular cloning of OSP94: A significant biomarker protein of hypertensive human heart and a member of HSP110 family. (PMID: 19169850) Mala J.G. … Takeuchi S. (Mol. Biotechnol. 2009) 3 4 22 64
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HSPA4L Gene

Sources for HSPA4L Gene

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