Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA4 Gene

protein-coding   GIFtS: 63
GCID: GC05P132415

Heat Shock 70kDa Protein 4

(Previous name: heat shock 70kD protein 4)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 41 2     RY2
Heat Shock 70kD Protein 41 2     Heat Shock 70 KDa Protein 42
Hsp70 RY1 2     Heat Shock Protein, 110 KDa2
Heat Shock 70-Related Protein APG-22 3     hsp702
APG-22     hsp70RY2
HS24/P522     APG23
HSPH22     HSP70RY3

External Ids:    HGNC: 52371   Entrez Gene: 33082   Ensembl: ENSG000001706067   OMIM: 6011135   UniProtKB: P349323   

Export aliases for HSPA4 gene to outside databases

Previous GC identifers: GC05P131909 GC05P132834 GC05P132418 GC05P132463 GC05P127579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPA4 Gene: 
HSPA4 (heat shock 70kDa protein 4) is a protein-coding gene. Diseases associated with HSPA4 include autoimmune inner ear disease, and chronic cervicitis, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include ATP binding. An important paralog of this gene is HYOU1.

Gene Wiki entry for HSPA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA4 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

HSPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P132415:  view genomic region     (about GC identifiers)

Start:
132,387,654 bp from pter      End:
132,442,141 bp from pter
Size:
54,488 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP74_HUMAN, P34932 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 4  
Size: 840 amino acids; 94331 Da
Subunit: Interacts with TJP1/ZO-1 (By similarity)
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=AAA02807.1; Type=Frameshift; Positions=567, 586, 697, 715, 722;
Secondary accessions: O95756 Q2TAL4

Explore the universe of human proteins at neXtProt for HSPA4: NX_P34932

Explore proteomics data for HSPA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P34932

  • HSPA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA4 Protein Expression
    REFSEQ proteins: NP_002145.3  
    ENSEMBL proteins: 
     ENSP00000302961  

    Human Recombinant Protein Products for HSPA4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HSPA4
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for HSPA4 
    OriGene Custom Protein Services for HSPA4
    GenScript Custom Purified and Recombinant Proteins Services for HSPA4
    Novus Biologicals HSPA4 Protein
    Novus Biologicals HSPA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS--

    HSPA4 for ontologies           About GeneDecksing



    HSPA4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HSPA4  (HSP70RY)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSPA4
    GenScript Superior Antibodies for HSPA4
    Novus Biologicals HSPA4 Antibodies
    Abcam antibodies for HSPA4
    Cloud-Clone Corp. Antibodies for HSPA4 
    ThermoFisher Antibody for HSPA4
    LSBio Antibodies in human, mouse, rat for HSPA4 

    Assay Products for HSPA4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSPA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSPA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPA4 
    Cloud-Clone Corp. CLIAs for HSPA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P34932

    ProtoNet protein and cluster: P34932

    UniProtKB/Swiss-Prot: HSP74_HUMAN, P34932
    Similarity: Belongs to the heat shock protein 70 family


    HSPA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for HSPA4:
    heat shock 70kDa protein A4,structurally related to aconitase

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding NAS8335910
         
    HSPA4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hspa4):
     behavior/neurological  cellular  endocrine/exocrine gland  mortality/aging  nervous system 
     reproductive system 

    HSPA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hspa4tm1Imad for HSPA4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA4:
    hsa-mir-1 (MIRT003977)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA4
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA4 (see all 13):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-320a hsa-miR-548am hsa-miR-374b hsa-miR-320d hsa-miR-624* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA4
    Sirion Biotech Customized adenovirus for overexpression of HSPA4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSPA4 (see all 8)
    OriGene ORF clones in mouse, rat for HSPA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA4 (NM_002154)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4
    Sirion Biotech Customized lentivirus for stable overexpression of HSPA4 
                         Customized lentivirus expression plasmids for stable overexpression of HSPA4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSPA4
    Search LifeMap BioReagents cell lines for HSPA4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA4 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    CFTR folding and maturation (norm and CF)0.37
    3Proteolysis Putative ubiquitin pathway
    Proteolysis Putative ubiquitin pathway0.97
    4Regulation of degradation of wt-CFTR
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5Androgen Signaling
    Androgen Signaling0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA4
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    1 R&D Systems Pathway for HSPA4
        Apoptosis Signaling Pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSPA4
        Androgen Signaling
    eNOS Signaling
    Cellular Transformation by HTLV1
    Parkinson's Disease Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HSPA4 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for HSPA4
        Parkin-Ubiquitin Proteasomal System pathway
    Validated targets of C-MYC transcriptional activation

    1 PharmGKB Pathway for HSPA4
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1         Kegg Pathway  (Kegg details for HSPA4):
        Antigen processing and presentation


    HSPA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/257 Interacting proteins for HSPA4 (P349322, 3 ENSP000003029614) via UniProtKB, MINT, STRING, and/or I2D (see all 257)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3, ENSP000002161604MINT-49161 I2D: score=2 STRING: ENSP00000216160
    ENSG00000231737Q96QC03, ENSP000004071814I2D: score=1 STRING: ENSP00000407181
    ENSG00000206489Q96QC03I2D: score=1 
    ENSG00000227804Q96QC03I2D: score=1 
    ENSG00000230995Q96QC03I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006986response to unfolded protein NAS8335910
    GO:0045040protein import into mitochondrial outer membrane IDA15644312
    GO:0051131chaperone-mediated protein complex assembly IDA15644312

    HSPA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSPA4 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSPA4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA4 (HSP74)

    10/149 Novoseek inferred chemical compound relationships for HSPA4 gene (see all 149)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 76.9 44 19995547 (5), 16311509 (3), 18852129 (3), 14633716 (2) (see all 18)
    17-(allylamino)-17-demethoxygeldanamycin 75.7 20 19383903 (4), 20090934 (2), 18429957 (2), 11280726 (1) (see all 11)
    pga1 71.4 31 8548766 (5), 7769835 (5), 8468116 (2), 11037055 (2) (see all 10)
    sodium arsenite 67.1 27 19358893 (4), 11740261 (3), 11322385 (3), 8464927 (1) (see all 16)
    geranylgeranylacetone 64.4 43 17182004 (7), 11693530 (5), 17702888 (4), 17684364 (3) (see all 10)
    ggmp 63.7 2 9447991 (1), 8887650 (1)
    quercetin 56.7 94 8198534 (8), 12969528 (4), 19017364 (4), 14625852 (4) (see all 37)
    cdcl2 54.2 15 9545559 (4), 8375467 (2), 15764298 (2), 9344607 (1) (see all 10)
    pga2 54.2 15 9824682 (4), 20153327 (2), 1549109 (2), 7926370 (1)
    atp 53.2 109 12832480 (3), 9830049 (3), 2203539 (2), 11170435 (2) (see all 74)

    Search CenterWatch for drugs/clinical trials and news about HSPA4 / HSP74

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA4 gene (2 alternative transcripts): 
    NM_198431.1  NM_002154.3  

    Unigene Cluster for HSPA4:

    Heat shock 70kDa protein 4
    Hs.90093  [show with all ESTs]
    Unigene Representative Sequence: NM_002154
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304858(uc003kyj.3) ENST00000504328 ENST00000514825
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSPA4
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA4 (see all 13):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-320a hsa-miR-548am hsa-miR-374b hsa-miR-320d hsa-miR-624* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSPA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA4
    Clone
    Products:
         
    OriGene clones in human, mouse for HSPA4 (see all 8)
    OriGene ORF clones in mouse, rat for HSPA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA4 (NM_002154)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4
    Sirion Biotech Customized lentivirus for stable overexpression of HSPA4 
                         Customized lentivirus expression plasmids for stable overexpression of HSPA4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPA4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA4

    Additional mRNA sequence: 

    AB023420.1 AB074275.1 AB209151.1 AK294859.1 AK295847.1 AK297762.1 AK299710.1 AK300050.1 
    AK300770.1 AK303382.1 AK304578.1 AK311097.1 AK311125.1 AK311135.1 AK311224.1 AK311299.1 
    AK311316.1 AK311422.1 AK311457.1 AK311465.1 AK311466.1 AK311471.1 AK311483.1 AK311615.1 
    AK311632.1 AK315862.1 AK315871.1 AK315875.1 AK315887.1 BC002526.2 BC110861.1 BC126122.1 
    BC126124.1 BT007375.1 L12723.1 X67643.1 

    18 DOTS entries:

    DT.100821700  DT.445307  DT.100821697  DT.40105813  DT.95169241  DT.217041  DT.95169252  DT.100821693 
    DT.100821695  DT.91828289  DT.99929734  DT.100030800  DT.95169249  DT.120883687  DT.120883716  DT.95088201 
    DT.95169244  DT.70100908 

    24/401 AceView cDNA sequences (see all 401):

    CD672985 AI952125 BM715241 BM746586 AU185949 AA433916 BQ008435 BQ216531 
    BQ232737 CB158526 CR601827 AA768539 BC002526 BM704069 BE388253 AW817315 
    AA442855 BU542656 BE383750 AA665471 AI005006 BQ427818 BF513175 BU686159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCAGTTG
    HSPA4 Expression
    About this image


    See HSPA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA4

    SOURCE GeneReport for Unigene cluster: Hs.90093
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA4 (see all 9): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSPA4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA4 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa41 , 5 heat shock protein 41, 5 90.6(n)1
    96.19(a)1
      11 (31.91 cM)5
    155251  NM_008300.31  NP_032326.31 
     532598145 
    chicken
    (Gallus gallus)
    Aves HSPA41 heat shock 70kDa protein 4 79.71(n)
    85.92(a)
      416339  XM_003642094.1  XP_003642142.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA46
    Uncharacterized protein
    84(a)
    1 ↔ 1
    2(127093088-127135197)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57992 Xenopus laevis, Similar to heat shock 70 kDa protein more 79.73(n)    BC041515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc41d052 Danio rerio cDNA clone MGC55506 IMAGE2641035, complete more 76.26(n)    BC051152.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70Cb6
    Hsc70Cb
    43(a)
    1 → many
    3L(14030119-14036786)
    worm
    (Caenorhabditis elegans)
    Secernentea C30C11.43 Msi3p 42(a)   III(8515890-8517059)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSE11 Sse1p 49.53(n)
    41.46(a)
      855998   NP_015219.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP911 heat shock protein 91 50.97(n)
    41.61(a)
      844333  NM_106642.4  NP_178111.1 
    rice
    (Oryza sativa)
    Liliopsida Os.264952 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.88(n)    AK122040.1 


    ENSEMBL Gene Tree for HSPA4 (if available)
    TreeFam Gene Tree for HSPA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA4 gene
    HYOU12  HSPA4L2  HSPH12  
    15 SIMAP similar genes for HSPA4 using alignment to 2 protein entries:     HSP74_HUMAN (see all proteins):
    HS24/P52    HS24/p52    HSPA4L    HSPH1    HSP70-1    HSPA7
    HSPA1A    HSPA1B    HSPA1L    HSPA14    HSPA6    HSPA8
    HSPA2    HSPA5    HYOU1

    HSPA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1261 SNPs in HSPA4 are shown (see all 1261)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907473071,2
    --132385663(+) ATAAAA/GTTTAC 1 -- us2k10--------
    rs1483143911,2
    C--132385767(+) TTCCC-/AAACTG
            
    AAACT
    1 -- us2k10--------
    rs579768641,2
    C--132385772(+) AAACT-/GAAACT
            
    CTGTA
    1 -- us2k10--------
    rs1808262911,2
    --132385879(+) TAAATG/TTTGAA 1 -- us2k10--------
    rs1859264851,2
    --132385906(+) AAAAAA/GAATTA 1 -- us2k10--------
    rs1152612561,2
    F--132386033(+) ATACAC/GTAAAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs93276401,2
    C,F,A,H--132386105(+) AATAAG/ACTACT 1 -- us2k122Minor allele frequency- A:0.43NS EA WA NA CSA 2348
    rs1490541331,2
    --132386222(+) CACCTC/GGTACT 1 -- us2k10--------
    rs77301251,2
    C,F,H--132386223(+) ACCTGG/ATACTT 1 -- us2k119Minor allele frequency- A:0.18NS EA WA NA CSA 2341
    rs77121811,2
    C,A--132386241(+) AAGAAT/CTAACA 1 -- us2k1 tfbs34Minor allele frequency- C:0.31WA NA 242

    HapMap Linkage Disequilibrium report for HSPA4 (132387654 - 132442141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HSPA4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830490CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA4
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601113    OMIM disorders: --

    20/170 diseases for HSPA4 (see all 170):    About MalaCards
    autoimmune inner ear disease    chronic cervicitis    inner ear disease    mixed glioma
    colonic disease    menieres disease    meniere's disease    spinocerebellar ataxia type 7
    multicentric castleman disease    transient cerebral ischemia    babesiosis    brain ischemia
    leishmaniasis    vulvovaginitis    verrucous carcinoma    lichen planus
    castleman's disease    ischemia    lafora disease    ocular melanoma

    5 diseases from the University of Copenhagen DISEASES database for HSPA4:
    Vascular disease     Cancer     Neurodegenerative disease     Brain disease
    Toxic encephalopathy

    HSPA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for HSPA4 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 95.2 1759 12969528 (9), 1910812 (5), 18088459 (5), 19670094 (4) (see all 99)
    tumors 47.9 385 16224158 (5), 19309230 (5), 16769335 (5), 9585177 (4) (see all 99)
    ischemia 40.7 139 8249024 (7), 8364736 (6), 8239864 (6), 7982052 (4) (see all 47)
    cancer 40 122 19716411 (4), 15553822 (4), 15741319 (4), 19017364 (3) (see all 69)
    cell damage 35.6 15 20123033 (2), 16492383 (2), 17209876 (1), 7922267 (1) (see all 10)
    spinocerebellar ataxia type 7 34.7 1 16039988 (1)
    neurodegenerative diseases 34.6 5 15673657 (1), 10562718 (1), 17536171 (1), 11044589 (1) (see all 5)
    necrosis 34.1 54 11341981 (3), 9755110 (2), 18336662 (2), 7749813 (2) (see all 40)
    muscular dystrophy oculopharyngeal 33.5 1 14729833 (1)
    erythroleukemia 30.4 8 9738016 (2), 17213196 (1), 9389084 (1), 16706166 (1) (see all 7)

    Genetic Association Database (GAD): HSPA4
    Human Genome Epidemiology (HuGE) Navigator: HSPA4 (8 documents)

    Export disorders for HSPA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA4 gene, integrated from 9 sources (see all 1863):
    (articles sorted by number of sources associating them with HSPA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. (PubMed id 8335910)1, 2, 3 Fathallah D.M.... Arnaout M.A. (1993)
    2. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    3. TAAR 6 and HSP-70 variations associated with bipolar disorder. (PubMed id 19766166)1, 4 Pae C.U....Serretti A. (2009)
    4. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    6. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. 1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients. (PubMed id 15992611)1, 4 Giacconi R....Mocchegiani E. (2005)
    10. Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes. (PubMed id 15507967)1, 4 Kalish R.B....Witkin S.S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3308 HGNC: 5237 AceView: HSPA4 Ensembl:ENSG00000170606 euGenes: HUgn3308
    ECgene: HSPA4 Kegg: 3308 H-InvDB: HSPA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA4 gene:
    Search GeneIP for patents involving HSPA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for HSPA4
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA4
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HSPA4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for HSPA4   OriGene clones in human, mouse for HSPA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4   OriGene Purified Protein for HSPA4  
     OriGene ORF clones in mouse, rat for HSPA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSPA4   OriGene Custom Protein Services for HSPA4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSPA4
     QIAGEN SeqTarget long-range PCR primers for resequencing HSPA4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA4
     GenScript Custom Purified and Recombinant Proteins Services for HSPA4 GenScript cDNA clones with any tag delivered in your preferred vector for HSPA4
     GenScript Custom Assay Services for HSPA4 GenScript Superior Antibodies for HSPA4
     GenScript Custom overexpressing Cell Line Services for HSPA4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for HSPA4  (HSP70RY)

     Regulatory tfbs in HSPA4 promoter
     Search Chromatin IP Primers for HSPA4
     RT2 qPCR Primer Assay in human, mouse, rat HSPA4
     GNC Network for HSPA4
     SABiosciences PCR Arrays including human, mouse, rat HSPA4
     Search Tocris compounds for HSPA4 (HSP74)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSPA4 antibodies
     HSPA4 proteins
     HSPA4 lysates
     Antibodies for HSPA4
     See all of Abcam's Antibodies, Kits and Proteins for HSPA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HSPA4
     Antibodies for HSPA4
     ELISAs for HSPA4
     CLIAs for HSPA4
     Search LifeMap BioReagents cell lines for HSPA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4
     SwitchGear 3'UTR luciferase reporter plasmids for HSPA4
     SwitchGear Promoter luciferase reporter plasmids for HSPA4
     ThermoFisher Antibody for HSPA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPA4
    Customized:
     lentivirus for stable overexpression of HSPA4
     lentivirus expression plasmids for stable overexpression of HSPA4
     adenovirus for overexpression of HSPA4
     LSBio Antibodies in human, mouse, rat for HSPA4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSPA4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4