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HSPA4 Gene

protein-coding   GIFtS: 63
GCID: GC05P132415

Heat Shock 70kDa Protein 4

(Previous name: heat shock 70kD protein 4)
  See HSPA4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 41 2     RY2
Heat Shock 70kD Protein 41 2     Epididymis Secretory Sperm Binding Protein Li 5a2
Hsp70 RY1 2     Heat Shock 70 KDa Protein 42
Heat Shock 70-Related Protein APG-22 3     Heat Shock Protein, 110 KDa2
APG-22     hsp702
HEL-S-5a2     hsp70RY2
HS24/P522     APG23
HSPH22     HSP70RY3

External Ids:    HGNC: 52371   Entrez Gene: 33082   Ensembl: ENSG000001706067   OMIM: 6011135   UniProtKB: P349323   

Export aliases for HSPA4 gene to outside databases

Previous GC identifers: GC05P131909 GC05P132834 GC05P132418 GC05P132463 GC05P127579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSPA4 Gene:
HSPA4 (heat shock 70kDa protein 4) is a protein-coding gene. Diseases associated with HSPA4 include chronic cervicitis, and spinocerebellar ataxia type 14. An important paralog of this gene is HYOU1.

Gene Wiki entry for HSPA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA4 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA4 promoter sequence
   Search Chromatin IP Primers for HSPA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

HSPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P132415:  view genomic region     (about GC identifiers)

Start:
132,387,654 bp from pter      End:
132,442,141 bp from pter
Size:
54,488 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSP74_HUMAN, P34932 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 4  
Size: 840 amino acids; 94331 Da
Subunit: Interacts with TJP1/ZO-1 (By similarity)
Sequence caution: Sequence=AAA02807.1; Type=Frameshift; Positions=567, 586, 697, 715, 722;
Secondary accessions: O95756 Q2TAL4

Explore the universe of human proteins at neXtProt for HSPA4: NX_P34932

Explore proteomics data for HSPA4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys53, Lys61, Lys124, Lys194, Lys221, Lys235, Lys305, Lys388, Lys422,
                                 Lys430, Lys573, Lys638, Lys674, Lys679, Lys686, Lys697, Lys704, Lys711, Lys719 (see all 24)
  • Modification sites at PhosphoSitePlus

  • See HSPA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002145.3  
    ENSEMBL proteins: 
     ENSP00000302961  

    HSPA4 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for HSPA4
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    Novus Biologicals HSPA4 Protein
    Novus Biologicals HSPA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA4

     
    Search eBioscience for Proteins for HSPA4 

     
    antibodies-online proteins for HSPA4 (79 products) 

     
    antibodies-online peptides for HSPA4

    HSPA4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA4
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    Abcam antibodies for HSPA4
    Cloud-Clone Corp. Antibodies for HSPA4
    ThermoFisher Antibody for HSPA4
    antibodies-online antibodies for HSPA4 (521 products) 

    HSPA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HSPA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPA4
    Cloud-Clone Corp. CLIAs for HSPA4
    Search eBioscience for ELISAs for HSPA4 
    antibodies-online kits for HSPA4 (38 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P34932

    ProtoNet protein and cluster: P34932

    UniProtKB/Swiss-Prot: HSP74_HUMAN, P34932
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for HSPA4:
    heat shock 70kDa protein A4,structurally related to aconitase

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding NAS8335910
         
    Find genes that share ontologies with HSPA4           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hspa4):
     behavior/neurological  cellular  endocrine/exocrine gland  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with HSPA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hspa4tm1Imad for HSPA4

       genOway: Develop your customized and physiologically relevant rodent model for HSPA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA4:
    hsa-mir-30c-5p (MIRT007050), hsa-mir-197-3p (MIRT048125), hsa-mir-320a (MIRT044647), hsa-mir-1 (MIRT003977), hsa-mir-26b-5p (MIRT030164), hsa-mir-148a-3p (MIRT048037), hsa-mir-10a-5p (MIRT047525), hsa-mir-942-5p (MIRT036559), hsa-mir-615-3p (MIRT039721)

    Block miRNA regulation of human, mouse, rat HSPA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA4 (see all 13):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-320a hsa-miR-548am hsa-miR-374b hsa-miR-320d hsa-miR-624* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPA4
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA4

    Clone
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    OriGene clones in human, mouse for HSPA4 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: HSPA4 (NM_002154)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA4
    Addgene plasmids for HSPA4 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSP74_HUMAN, P34932: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton3
    cytosol3
    endoplasmic reticulum3
    mitochondrion3
    chloroplast2
    extracellular2
    golgi apparatus2
    lysosome2
    plasma membrane2
    vacuole2
    endosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA15644312
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with HSPA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA4 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    3Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Androgen Signaling
    Androgen Signaling0.52
    5Nanog in Mammalian ESC Pluripotency
    eNOS Signaling0.48


    Find genes that share SuperPaths with HSPA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSPA4
        Apoptosis Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSPA4
        Androgen Signaling
    eNOS Signaling
    Cellular Transformation by HTLV1
    Parkinson's Disease Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSPA4 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for HSPA4
        Parkin-Ubiquitin Proteasomal System pathway
    Validated targets of C-MYC transcriptional activation

    1 PharmGKB Pathway for HSPA4
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    1 Kegg Pathway  (Kegg details for HSPA4):
        Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA4 (see all 9): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA4 (P349322, 3 ENSP000003029614) via UniProtKB, MINT, STRING, and/or I2D (see all 430)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAB1Q157502, 3, ENSP000002161604MINT-49161 I2D: score=2 STRING: ENSP00000216160
    TRAF2Q129332, 3, ENSP000002476684MINT-49532 I2D: score=2 STRING: ENSP00000247668
    ENSG00000231737Q96QC03, ENSP000004071814I2D: score=1 STRING: ENSP00000407181
    ENSG00000206489Q96QC03I2D: score=1 
    ENSG00000227804Q96QC03I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006986response to unfolded protein NAS8335910
    GO:0045040protein import into mitochondrial outer membrane IDA15644312
    GO:0051131chaperone-mediated protein complex assembly IDA15644312

    Find genes that share ontologies with HSPA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA4 (HSP74)

    Selected Novoseek inferred chemical compound relationships for HSPA4 gene (see all 149)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 76.9 44 19995547 (5), 16311509 (3), 18852129 (3), 14633716 (2) (see all 18)
    17-(allylamino)-17-demethoxygeldanamycin 75.7 20 19383903 (4), 20090934 (2), 18429957 (2), 11280726 (1) (see all 11)
    pga1 71.4 31 8548766 (5), 7769835 (5), 8468116 (2), 11037055 (2) (see all 10)
    sodium arsenite 67.1 27 19358893 (4), 11740261 (3), 11322385 (3), 8464927 (1) (see all 16)
    geranylgeranylacetone 64.4 43 17182004 (7), 11693530 (5), 17702888 (4), 17684364 (3) (see all 10)
    ggmp 63.7 2 9447991 (1), 8887650 (1)
    quercetin 56.7 94 8198534 (8), 12969528 (4), 19017364 (4), 14625852 (4) (see all 37)
    cdcl2 54.2 15 9545559 (4), 8375467 (2), 15764298 (2), 9344607 (1) (see all 10)
    pga2 54.2 15 9824682 (4), 20153327 (2), 1549109 (2), 7926370 (1)
    atp 53.2 109 12832480 (3), 9830049 (3), 2203539 (2), 11170435 (2) (see all 74)



    Find genes that share compounds with HSPA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA4 gene (2 alternative transcripts): 
    NM_198431.1  NM_002154.3  

    Unigene Cluster for HSPA4:

    Heat shock 70kDa protein 4
    Hs.90093  [show with all ESTs]
    Unigene Representative Sequence: NM_002154
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304858(uc003kyj.3) ENST00000504328 ENST00000514825
    miRNA
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    Block miRNA regulation of human, mouse, rat HSPA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSPA4 (see all 13):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-320a hsa-miR-548am hsa-miR-374b hsa-miR-320d hsa-miR-624* hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA4 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for HSPA4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA4
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA4
      QuantiFast Probe-based Assays in human, mouse, rat HSPA4

    Additional mRNA sequence: 

    AB023420.1 AB074275.1 AB209151.1 AK294859.1 AK295847.1 AK297762.1 AK299710.1 AK300050.1 
    AK300770.1 AK303382.1 AK304578.1 AK311097.1 AK311125.1 AK311135.1 AK311224.1 AK311299.1 
    AK311316.1 AK311422.1 AK311457.1 AK311465.1 AK311466.1 AK311471.1 AK311483.1 AK311615.1 
    AK311632.1 AK315862.1 AK315871.1 AK315875.1 AK315887.1 BC002526.2 BC110861.1 BC126122.1 
    BC126124.1 BT007375.1 L12723.1 X67643.1 

    18 DOTS entries:

    DT.100821700  DT.445307  DT.100821697  DT.40105813  DT.95169241  DT.217041  DT.95169252  DT.100821693 
    DT.100821695  DT.91828289  DT.99929734  DT.100030800  DT.95169249  DT.120883687  DT.120883716  DT.95088201 
    DT.95169244  DT.70100908 

    Selected AceView cDNA sequences (see all 401):

    BF513175 BQ431980 NM_002154 BE383750 AI911599 BF026277 CR601827 AI742972 
    NM_198431 AI799801 CN481241 AI005006 BQ216531 BQ427818 BM720004 BI833111 
    BM715241 BE888749 AL546599 AW817315 BM787246 AU185949 AA354293 BQ008435 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATCCAGTTG
    HSPA4 Expression
    About this image

    HSPA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90093
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA4 (see all 9): 
              mTOR Signaling in human mouse rat
              Parkinson's Disease in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA4 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa41 , 5 heat shock protein 41, 5 90.6(n)1
    96.19(a)1
      11 (31.91 cM)5
    155251  NM_008300.31  NP_032326.31 
     532598145 
    chicken
    (Gallus gallus)
    Aves HSPA41 heat shock 70kDa protein 4 79.94(n)
    86.17(a)
      416339  XM_414655.4  XP_414655.2 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA46
    heat shock 70kDa protein 4
    84(a)
    1 ↔ 1
    2(127093088-127135197)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57992 Xenopus laevis, Similar to heat shock 70 kDa protein more 79.73(n)    BC041515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc41d052 Danio rerio cDNA clone MGC55506 IMAGE2641035, complete more 76.26(n)    BC051152.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70Cb1 Hsc70Cb 51.89(n)
    45.19(a)
      39557  NM_001202174.2  NP_001189103.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C30C11.41 , 3 Msi3p3
    C30C11.41
    42(a)3
    51.41(n)1
    45.14(a)1
      III(8515890-8517059)3
    1761951  NM_066467.51  NP_498868.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSE11 SSE1 49.53(n)
    41.46(a)
      855998   NP_015219.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP911 HSP91 50.85(n)
    41.74(a)
      844333  NM_106642.4  NP_178111.1 
    rice
    (Oryza sativa)
    Liliopsida Os.264952 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.88(n)    AK122040.1 


    ENSEMBL Gene Tree for HSPA4 (if available)
    TreeFam Gene Tree for HSPA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA4 gene
    HYOU12  HSPA4L2  HSPH12  
    15 SIMAP similar genes for HSPA4 using alignment to 2 protein entries:     HSP74_HUMAN (see all proteins):
    HS24/P52    HS24/p52    HSPA4L    HSPH1    HSP70-1    HSPA7
    HSPA1A    HSPA1B    HSPA1L    HSPA14    HSPA6    HSPA8
    HSPA2    HSPA5    HYOU1

    Find genes that share paralogs with HSPA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA4 (see all 1261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907473071,2
    --132385663(+) ATAAAA/GTTTAC 1 -- us2k10--------
    rs1483143911,2
    C--132385767(+) TTCCC-/AAACTG
            
    AAACT
    1 -- us2k10--------
    rs579768641,2
    C--132385772(+) AAACT-/GAAACT
            
    CTGTA
    1 -- us2k10--------
    rs1808262911,2
    --132385879(+) TAAATG/TTTGAA 1 -- us2k10--------
    rs1859264851,2
    --132385906(+) AAAAAA/GAATTA 1 -- us2k10--------
    rs1152612561,2
    F--132386033(+) ATACAC/GTAAAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs93276401,2
    C,F,A,H--132386105(+) AATAAG/ACTACT 1 -- us2k122Minor allele frequency- A:0.43NS EA WA NA CSA 2348
    rs1490541331,2
    --132386222(+) CACCTC/GGTACT 1 -- us2k10--------
    rs77301251,2
    C,F,H--132386223(+) ACCTGG/ATACTT 1 -- us2k119Minor allele frequency- A:0.18NS EA WA NA CSA 2341
    rs77121811,2
    C,A--132386241(+) AAGAAT/CTAACA 1 -- us2k1 tfbs34Minor allele frequency- C:0.31WA NA 242

    HapMap Linkage Disequilibrium report for HSPA4 (132387654 - 132442141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HSPA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830490CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA4
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601113    OMIM disorders: --

    16 diseases for HSPA4:    
    About MalaCards
    chronic cervicitis    spinocerebellar ataxia type 14    autoimmune inner ear disease    vulvovaginitis
    inner ear disease    cervicitis    mixed glioma    menieres disease
    babesiosis    colonic disease    spinocerebellar ataxia type 7    scrub typhus
    leishmaniasis    oculopharyngeal muscular dystrophy    ischemia    meniere's disease

    5 diseases from the University of Copenhagen DISEASES database for HSPA4:
    Vascular disease     Cancer     Neurodegenerative disease     Brain disease
    Toxic encephalopathy

    Find genes that share disorders with HSPA4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSPA4 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 95.2 1759 12969528 (9), 1910812 (5), 18088459 (5), 19670094 (4) (see all 99)
    tumors 47.9 385 16224158 (5), 19309230 (5), 16769335 (5), 9585177 (4) (see all 99)
    ischemia 40.7 139 8249024 (7), 8364736 (6), 8239864 (6), 7982052 (4) (see all 47)
    cancer 40 122 19716411 (4), 15553822 (4), 15741319 (4), 19017364 (3) (see all 69)
    cell damage 35.6 15 20123033 (2), 16492383 (2), 17209876 (1), 7922267 (1) (see all 10)
    spinocerebellar ataxia type 7 34.7 1 16039988 (1)
    neurodegenerative diseases 34.6 5 15673657 (1), 10562718 (1), 17536171 (1), 11044589 (1) (see all 5)
    necrosis 34.1 54 11341981 (3), 9755110 (2), 18336662 (2), 7749813 (2) (see all 40)
    muscular dystrophy oculopharyngeal 33.5 1 14729833 (1)
    erythroleukemia 30.4 8 9738016 (2), 17213196 (1), 9389084 (1), 16706166 (1) (see all 7)

    Genetic Association Database (GAD): HSPA4
    Human Genome Epidemiology (HuGE) Navigator: HSPA4 (8 documents)

    Export disorders for HSPA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA4 gene, integrated from 10 sources (see all 1884):
    (articles sorted by number of sources associating them with HSPA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. (PubMed id 8335910)1, 2, 3 Fathallah D.M.... Arnaout M.A. (J. Immunol. 1993)
    2. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    3. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    4. TAAR 6 and HSP-70 variations associated with bipolar disorder. (PubMed id 19766166)1, 4 Pae C.U....Serretti A. (Neurosci. Lett. 2009)
    5. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. 1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients. (PubMed id 15992611)1, 4 Giacconi R....Mocchegiani E. (Mech. Ageing Dev. 2005)
    10. Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes. (PubMed id 15507967)1, 4 Kalish R.B....Witkin S.S. (Am. J. Obstet. Gynecol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3308 HGNC: 5237 AceView: HSPA4 Ensembl:ENSG00000170606 euGenes: HUgn3308
    ECgene: HSPA4 Kegg: 3308 H-InvDB: HSPA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA4 gene:
    Search GeneIP for patents involving HSPA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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