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Aliases for HSPA4 Gene

Aliases for HSPA4 Gene

  • Heat Shock Protein Family A (Hsp70) Member 4 2 3 5
  • Heat Shock 70-Related Protein APG-2 3 4
  • Heat Shock 70kDa Protein 4 2 3
  • Heat Shock 70kD Protein 4 2 3
  • Hsp70 RY 2 3
  • Hsp70RY 3 4
  • Epididymis Secretory Sperm Binding Protein Li 5a 3
  • Heat Shock 70 KDa Protein 4 3
  • Heat Shock Protein, 110 KDa 3
  • HEL-S-5a 3
  • HS24/P52 3
  • APG-2 3
  • HSPH2 3
  • Hsp70 3
  • APG2 4
  • RY 3

External Ids for HSPA4 Gene

Previous GeneCards Identifiers for HSPA4 Gene

  • GC05P131909
  • GC05P132834
  • GC05P132418
  • GC05P132463
  • GC05P132415
  • GC05P127579

Summaries for HSPA4 Gene

GeneCards Summary for HSPA4 Gene

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Ischemia and Transient Cerebral Ischemia. Among its related pathways are Development_Glucocorticoid receptor signaling and Allograft rejection. An important paralog of this gene is HSPA4L.

Gene Wiki entry for HSPA4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA4 Gene

Genomics for HSPA4 Gene

Regulatory Elements for HSPA4 Gene

Enhancers for HSPA4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F133048 1.2 ENCODE 11.1 -0.9 -862 5.5 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 AFF4 IL4 RAD50 HSPA4 MIR3936 ENSG00000224431 ENSG00000202533 GC05M133049 GC05M133050
GH05F133102 1.1 Ensembl ENCODE 10.5 +53.0 52955 5.0 HDGF CTCF PKNOX1 MXI1 TBL1XR1 ZNF133 SIN3A MAX ZNF384 ZFHX2 HSPA4 MIR1289-2 LOC105379178 ENSG00000279691
GH05F133032 1.7 FANTOM5 Ensembl ENCODE 5.4 -18.6 -18550 2.0 CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF2 YY1 GLIS2 GATA2 ZNF143 HSPA4 ZCCHC10 AFF4 GC05M133049
GH05F133055 0.7 Ensembl 10.7 +5.3 5339 3.8 SOX5 SOX13 KLF1 MTA2 RARA IKZF1 BCL6 SMAD4 PRDM1 MIXL1 HSPA4 AFF4 ENSG00000279691 LOC105379178
GH05F133130 0.9 Ensembl 6.7 +78.7 78739 0.6 HDGF KLF17 ZNF766 FOS CREM ZEB2 NR2F2 CREB3 ZNF589 ZNF341 HSPA4 SHROOM1 LOC105379178 CTB-49A3.2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA4 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for HSPA4 Gene

133,051,962 bp from pter
133,106,449 bp from pter
54,488 bases
Plus strand

Genomic View for HSPA4 Gene

Genes around HSPA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA4 Gene

Proteins for HSPA4 Gene

  • Protein details for HSPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 4
    Protein Accession:
    Secondary Accessions:
    • O95756
    • Q2TAL4
    • Q9BUK9

    Protein attributes for HSPA4 Gene

    840 amino acids
    Molecular mass:
    94331 Da
    Quaternary structure:
    • Interacts with TJP1/ZO-1.
    • Sequence=AAA02807.1; Type=Frameshift; Positions=567, 586, 697, 715, 722; Evidence={ECO:0000305};

    Alternative splice isoforms for HSPA4 Gene


neXtProt entry for HSPA4 Gene

Post-translational modifications for HSPA4 Gene

  • Ubiquitination at Lys 44, Lys 53, Lys 61, Lys 124, Lys 194, Lys 221, Lys 305, Lys 422, Lys 430, Lys 573, Lys 638, Lys 679, Lys 686, Lys 697, Lys 704, Lys 711, Lys 719, Lys 736, Lys 748, Lys 754, and Lys 773
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSPA4 (HSP70RY)
  • Abcam antibodies for HSPA4
  • Cloud-Clone Corp. Antibodies for HSPA4
  • Santa Cruz Biotechnology (SCBT) Antibodies for HSPA4

No data available for DME Specific Peptides for HSPA4 Gene

Domains & Families for HSPA4 Gene

Gene Families for HSPA4 Gene

Protein Domains for HSPA4 Gene

Suggested Antigen Peptide Sequences for HSPA4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA4: view

Function for HSPA4 Gene

Molecular function for HSPA4 Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A4,structurally related to aconitase

Gene Ontology (GO) - Molecular Function for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA,NAS 8335910
genes like me logo Genes that share ontologies with HSPA4: view
genes like me logo Genes that share phenotypes with HSPA4: view

Animal Models for HSPA4 Gene

MGI Knock Outs for HSPA4:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA4 Gene

Localization for HSPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA4 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
plasma membrane 2
lysosome 2
golgi apparatus 2
endosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 21231916
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HSPA4: view

Pathways & Interactions for HSPA4 Gene

genes like me logo Genes that share pathways with HSPA4: view

Gene Ontology (GO) - Biological Process for HSPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein NAS 8335910
GO:0045040 protein import into mitochondrial outer membrane IDA 15644312
GO:0051131 chaperone-mediated protein complex assembly IDA 15644312
genes like me logo Genes that share ontologies with HSPA4: view

No data available for SIGNOR curated interactions for HSPA4 Gene

Drugs & Compounds for HSPA4 Gene

(76) Drugs for HSPA4 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(74) Additional Compounds for HSPA4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HSPA4 Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA4: view

Transcripts for HSPA4 Gene

Unigene Clusters for HSPA4 Gene

Heat shock 70kDa protein 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA4 Gene

No ASD Table

Relevant External Links for HSPA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA4 Gene

Protein differential expression in normal tissues from HIPED for HSPA4 Gene

This gene is overexpressed in Lymph node (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA4 Gene

Protein tissue co-expression partners for HSPA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA4 Gene:


SOURCE GeneReport for Unigene cluster for HSPA4 Gene:

genes like me logo Genes that share expression patterns with HSPA4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA4 Gene

Orthologs for HSPA4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPA4 34 35
  • 99.84 (n)
(Bos Taurus)
Mammalia HSPA4 34 35
  • 94.8 (n)
(Canis familiaris)
Mammalia HSPA4 34 35
  • 94.4 (n)
(Mus musculus)
Mammalia Hspa4 34 16 35
  • 90.6 (n)
(Rattus norvegicus)
Mammalia Hspa4 34
  • 90.36 (n)
(Ornithorhynchus anatinus)
Mammalia HSPA4 35
  • 90 (a)
(Monodelphis domestica)
Mammalia HSPA4 35
  • 79 (a)
(Gallus gallus)
Aves HSPA4 34 35
  • 79.94 (n)
(Anolis carolinensis)
Reptilia HSPA4 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa4 34
  • 76.69 (n)
MGC76295 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5799 34
(Danio rerio)
Actinopterygii hspa4b 35
  • 73 (a)
hspa4a 34 35
  • 68.11 (n)
wufc41d05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10287 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010331 34
  • 53.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70Cb 34 35
  • 51.89 (n)
(Caenorhabditis elegans)
Secernentea C30C11.4 36 34
  • 51.41 (n)
hsp-110 35
  • 45 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24597g 34
  • 50 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 34 35
  • 49.53 (n)
SSE2 35
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR212W 34
  • 48.15 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP91 34
  • 50.85 (n)
(Oryza sativa)
Liliopsida Os01g0180800 34
  • 51.8 (n)
Os.26495 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pss1 34
  • 51.49 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05269 34
  • 49.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9760 35
  • 44 (a)
Species where no ortholog for HSPA4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA4 Gene

Gene Tree for HSPA4 (if available)
Gene Tree for HSPA4 (if available)

Paralogs for HSPA4 Gene

Paralogs for HSPA4 Gene

(15) SIMAP similar genes for HSPA4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPA4: view

Variants for HSPA4 Gene

Sequence variations from dbSNP and Humsavar for HSPA4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10038003 -- 133,077,629(+) ATTTC(A/G)GGGTT intron-variant
rs10043154 -- 133,056,009(+) GTAGG(C/T)GGAGG intron-variant
rs10043832 -- 133,056,443(+) atttt(C/T)gtatt intron-variant
rs10060131 -- 133,084,122(+) ctgat(A/G)tgctt intron-variant
rs10061432 -- 133,067,261(+) ATGCT(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA4 Gene

Variant ID Type Subtype PubMed ID
nsv1128190 CNV deletion 24896259
nsv830490 CNV gain 17160897

Variation tolerance for HSPA4 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA4 Gene

Disorders for HSPA4 Gene

MalaCards: The human disease database

(19) MalaCards diseases for HSPA4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transient cerebral ischemia
  • tia
  • post kala-azar dermal leishmaniasis
stroke, ischemic
  • ischemic stroke
salpingitis isthmica nodosa
- elite association - COSMIC cancer census association via MalaCards
Search HSPA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA4 Gene

Publications for HSPA4 Gene

  1. Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5. (PMID: 8335910) Fathallah D.M. … Arnaout M.A. (J. Immunol. 1993) 2 3 4 64
  2. Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. (PMID: 20053985) Hwang C.Y. … Song B. (J. Biol. Chem. 2010) 3 22 64
  3. [The significance of the changes in expressions of heat shock protein 70 and heme oxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]. (PMID: 20170613) Zuo L.P. … Ma Z.F. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2010) 3 22 64
  4. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts. (PMID: 20069064) Ayub H. … Qamar R. (Mol. Vis. 2010) 3 22 64
  5. Geldanamycin inhibits TGF-beta signaling through induction of Hsp70. (PMID: 19995547) Yun C.H. … Lee H.J. (Arch. Biochem. Biophys. 2010) 3 22 64

Products for HSPA4 Gene

Sources for HSPA4 Gene

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